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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CBR4-GALNTL6 (FusionGDB2 ID:13418)

Fusion Gene Summary for CBR4-GALNTL6

Fusion gene summary

Fusion gene information	Fusion gene name: CBR4-GALNTL6
	Fusion gene ID: 13418
		Hgene	Tgene
	Gene symbol	CBR4	GALNTL6
	Gene ID	84869	442117
	Gene name	carbonyl reductase 4	polypeptide N-acetylgalactosaminyltransferase like 6
	Synonyms	SDR45C1	GALNACT20\|GALNT17\|GalNAc-T6L
	Cytomap	4q32.3	4q34.1
	Type of gene	protein-coding	protein-coding
	Description	carbonyl reductase family member 43-ketoacyl-[acyl-carrier-protein] reductase beta subunit3-oxoacyl-[acyl-carrier-protein] reductaseKAR beta subunitcarbonic reductase 4quinone reductase CBR4short chain dehydrogenase/reductase family 45C member 1	polypeptide N-acetylgalactosaminyltransferase-like 6GaNTase 17GalNAc transferase 17UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20UDP-N-acetyl-alpha-D-gala
	Modification date	20200313	20200313
	UniProtAcc	Q8N4T8	Q49A17
	Ensembl transtripts involved in fusion gene	ENST00000306193, ENST00000509108, ENST00000504480,	ENST00000457021, ENST00000511251, ENST00000506823, ENST00000508122,
Fusion gene scores	* DoF score	6 X 4 X 5=120	16 X 15 X 8=1920
	# samples	6	18
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1920*10)=-3.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CBR4 [Title/Abstract] AND GALNTL6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CBR4(169923222)-GALNTL6(173730512), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CBR4	GO:0051289	protein homotetramerization	19000905
Hgene	CBR4	GO:0051290	protein heterotetramerization	25203508
Hgene	CBR4	GO:0055114	oxidation-reduction process	25203508
Tgene	GALNTL6	GO:0018243	protein O-linked glycosylation via threonine	22186971

Fusion gene breakpoints across CBR4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GALNTL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-ER-A2NF-01A	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+

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Fusion Gene ORF analysis for CBR4-GALNTL6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000306193	ENST00000457021	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+
5CDS-intron	ENST00000306193	ENST00000511251	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+
5UTR-3CDS	ENST00000509108	ENST00000506823	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+
5UTR-3CDS	ENST00000509108	ENST00000508122	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+
5UTR-intron	ENST00000509108	ENST00000457021	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+
5UTR-intron	ENST00000509108	ENST00000511251	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+
In-frame	ENST00000306193	ENST00000506823	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+
In-frame	ENST00000306193	ENST00000508122	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+
intron-3CDS	ENST00000504480	ENST00000506823	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+
intron-3CDS	ENST00000504480	ENST00000508122	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+
intron-intron	ENST00000504480	ENST00000457021	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+
intron-intron	ENST00000504480	ENST00000511251	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000306193

CBR4

chr4

169923222

ENST00000506823

GALNTL6

chr4

173730512

3416

704

115

1956

613

ENST00000306193

CBR4

chr4

169923222

ENST00000508122

GALNTL6

chr4

173730512

1957

704

115

1956

614

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000306193	ENST00000506823	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+	0.000606375	0.9993936
ENST00000306193	ENST00000508122	CBR4	chr4	169923222	-	GALNTL6	chr4	173730512	+	0.002183178	0.9978168

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Fusion Genomic Features for CBR4-GALNTL6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CBR4	chr4	169923221	-	GALNTL6	chr4	173730511	+	9.63E-07	0.99999905
CBR4	chr4	169923221	-	GALNTL6	chr4	173730511	+	9.63E-07	0.99999905

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CBR4-GALNTL6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:169923222/chr4:173730512)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CBR4 Q8N4T8	GALNTL6 Q49A17
FUNCTION: The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (PubMed:19000905). Both homotetramer and the heterotetramer have broad substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508). {ECO:0000269\|PubMed:19000905, ECO:0000269\|PubMed:19571038, ECO:0000269\|PubMed:25203508}.	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CBR4

chr4:169923222

chr4:173730512

ENST00000306193

11_14

178

238.0

Nucleotide binding

NADP

Hgene

CBR4

chr4:169923222

chr4:173730512

ENST00000306193

34_35

178

238.0

Nucleotide binding

NADP

Hgene

CBR4

chr4:169923222

chr4:173730512

ENST00000306193

83_85

178

238.0

Nucleotide binding

NADP

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000506823

453_585

184

602.0

Domain

Ricin B-type lectin

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000508122

453_585

167

585.0

Domain

Ricin B-type lectin

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000506823

306_368

184

602.0

Region

Note=Catalytic subdomain B

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000508122

306_368

167

585.0

Region

Note=Catalytic subdomain B

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CBR4

chr4:169923222

chr4:173730512

ENST00000306193

181_183

178

238.0

Nucleotide binding

NADP

Hgene

CBR4

chr4:169923222

chr4:173730512

ENST00000504480

11_14

180.0

Nucleotide binding

NADP

Hgene

CBR4

chr4:169923222

chr4:173730512

ENST00000504480

181_183

180.0

Nucleotide binding

NADP

Hgene

CBR4

chr4:169923222

chr4:173730512

ENST00000504480

34_35

180.0

Nucleotide binding

NADP

Hgene

CBR4

chr4:169923222

chr4:173730512

ENST00000504480

83_85

180.0

Nucleotide binding

NADP

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000506823

139_248

184

602.0

Region

Note=Catalytic subdomain A

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000508122

139_248

167

585.0

Region

Note=Catalytic subdomain A

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000506823

1_7

184

602.0

Topological domain

Cytoplasmic

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000506823

29_601

184

602.0

Topological domain

Lumenal

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000508122

1_7

167

585.0

Topological domain

Cytoplasmic

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000508122

29_601

167

585.0

Topological domain

Lumenal

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000506823

8_28

184

602.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

GALNTL6

chr4:169923222

chr4:173730512

ENST00000508122

8_28

167

585.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for CBR4-GALNTL6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>13418_13418_1_CBR4-GALNTL6_CBR4_chr4_169923222_ENST00000306193_GALNTL6_chr4_173730512_ENST00000506823_length(transcript)=3416nt_BP=704nt
ATTACTATTGTGCGGCTGCAGGAGGTGTCGAGCGGCGTTATTTTTTTTTGCGGTTTGCCTTTTTTTTTCTTTTTTTTTTTTTTGGAACCG
CGGTTGTTTAAAAGCCTGAGGGAACCTGGAGAGGGGCTCCCACTCCCTACCCTCTTTCCTCCGAGTTTGTGACTCCGAGATGGACAAAGT
GTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAG
AAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAACATGATGTTCA
AAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAG
AACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGGACTATGATTCA
ACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGG
ATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGAACACCTGAAGGATAA
ATTGGAAGAATACATGGCCCGATTTTCCAAAGTGAGGATTGTTCGCACCAAGAAAAGAGAAGGACTCATCCGGACCCGTCTCCTGGGGGC
ATCTATGGCCAGAGGAGAAGTCCTGACATTCCTGGACTCCCACTGCGAGGTCAATGTGAACTGGCTGCCCCCACTCCTCAACCAAATTGC
ACTAAACCACAAAACCATCGTGTGTCCCATGATCGATGTCATTGACCACAATCACTTCGGGTATGAGGCACAAGCTGGGGATGCCATGCG
AGGAGCCTTCGACTGGGAAATGTACTACAAAAGAATCCCCATCCCTCCAGAGCTCCAGAGGGCAGATCCCAGCGACCCTTTTGAGTCTCC
TGTTATGGCTGGAGGTCTCTTTGCTGTGGATCGGAAATGGTTTTGGGAATTGGGTGGCTATGATCCAGGTTTAGAAATCTGGGGAGGAGA
ACAGTATGAAATCTCTTTTAAGGTTTGGATGTGTGGAGGAGAAATGTTTGATGTTCCATGTTCTAGAGTTGGTCATATCTACAGGAAGTA
CGTTCCATACAAAGTTCCATCTGGGACAAGCCTGGCAAGAAACCTGAAGCGGGTAGCTGAGACCTGGATGGATGAATTTGCCGAGTACAT
TTACCAGCGGCGGCCGGAGTACAGGCATCTCTCCACGGGGGACATCTCTGCCCAGAAGGAGCTGCGCAAGCAGCTCAAGTGCAAGGACTT
CAAATGGTTCATGGCTGCTGTGGCCTGGGACGTGCCTAAATACTACCCTCCAGTGGAGCCCCCGCCTGCTGCCTGGGGGGAGATCCGAAA
TGTGGCAGCAAATCTCTGTGTGGACAGCAAGCATGGAGCCACCGGAACAGAGCTGAGGCTGGACATCTGTGTCAAGGATGGTTCTGAAAG
AACATGGTCTCATGAACAGCTTTTTACCTTTGGATGGAGAGAAGATATTCGACCCGGTGAGCCACTGCATACCCGGAAATTCTGCTTTGA
TGCGATCTCACACAACAGCCCCGTTACACTCTATGACTGTCATGGCATGAAGGGGAACCAGCTCTGGGGATACCGGAAGGACAGAACATT
ATTCCATCCTGTGAGCAACAGCTGCATGGATTGCAACCCCGCAGAGAAGAAGATTTTCATGGCCAGATGTGACCCTCTCTCTGAGACTCA
GCAGTGGATTTTTGAACACATTAATATGACTGTTTTAGAAAAATTTAACCACCATGCCAACTCCTAGAAAGAAGAAAGGAAGAAAGAGTG
ATTACCTACAGGTTATAAATTAAATTTTAGCCAGCATCTGGGTCGAAGGAGTCAGGAATAACATTTCCTCGATCCAGGAAGGCTGGTTTA
AAAATTTGCAAATGCCATGTCAAAGTAGGTTGTTTTGAAGAACTTCCTGCATCTGAAGAACTTGGCTGAGAATCTCACCAGCTGCTTCTG
AGAACTCGAGACTAGCAGTTCCCTTGCTGGCCAAGGGCAAAGATAATTTAGGGACTTTTCAAAACAACTGCTGAGCTAATAAATCCTAGC
ATTTCTCAGGTCAAATCCTGCAGTAGTGAGTAGCTATGAATGGATCCTATTAACTGGGTGGGAGGGGGGTGAAAATGGAGTGCATGACTG
CTCTGACAACCTGAGGATATCACAGGTTTAGAACTAGCCAAGCTTAAGGGGTGAGCTGTACTCTTTGGTGCCATTCTCTGACTAAGAATG
GGTTCAGCAGGTTTAACCCTTAAAAGTGCTGCAGATGATTTCAGAGTGCTCACACTATTCTGTTTTTTTTATTTTTATTTTTAAATGAGG
GTGCAATATCTAATGTAAGACTTAAATTACATAATGAAATGGACATCCAGTGTTCCCATTCTTTCGTTTATATTTGCCATTTTTTTTTCA
GAGCAAAGTTTCTTTTTTATGAAAGTTCATGCTCCATGAATCCACTGAATTTCTAATTCAGTGCCCTTCTATGAATCCAGTTAAAAACAA
AAGCAAAAGCAAAAATCTATGCTATCAAGTTACTCCAAAGAAAGATTTCACAGAAGCAGCAAAACCATATAAGATTTAGGAGAGGGACTT
CCCTGGGAAATCTATTTTTACTTTTCTATTATTTTTAAAATCTTAAAAGTCTGATATTTGTCCAGTCATAATTTTTATTAAGCAAGGAAA
TGGAGTGAGTTTGATGTAATTTGTTTAGGAGATTCTTAAACCCAAATAAATCTACACTCCAAGTGATATGTGAAAATGGCTTAGTTCACT
TCAATTCTGTTTAGTCAGTGGTGGGAGCTTAGAAGTGGTTTTATTTGTTCGTTTGTTTGGGTTTTGCTTTTGTTTTTTATTTTTTTCTTG
TTTTTTTTTTGTAGTGTTGAATTAATGATGTTCTTTTATTTGGAAGCTCATAAAAGGAATTACCATTAATAAAGTGTTTCTGACACCATT
TTCTGTTAATGGGACAATATTTCGGGGATGAAGAAAGGAATGCTCCGAAAACTAAATGGAACACTTAATCCTTAAAGCAATTTTTTACTG
TTCAATAATATCACATTGGGGGAAGAAAACACAGGTATCAAGGTGGTTCTTGGGAAAAAAGAATCATGTTTATTATATATCTCTCAAGTT

>13418_13418_1_CBR4-GALNTL6_CBR4_chr4_169923222_ENST00000306193_GALNTL6_chr4_173730512_ENST00000506823_length(amino acids)=613AA_BP=196
MERGSHSLPSFLRVCDSEMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEK
HLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRAL
AKEVARKKIRVNVVAPEHLKDKLEEYMARFSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVC
PMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKV
WMCGGEMFDVPCSRVGHIYRKYVPYKVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVA
WDVPKYYPPVEPPPAAWGEIRNVAANLCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCFDAISHNSPV

--------------------------------------------------------------
>13418_13418_2_CBR4-GALNTL6_CBR4_chr4_169923222_ENST00000306193_GALNTL6_chr4_173730512_ENST00000508122_length(transcript)=1957nt_BP=704nt
ATTACTATTGTGCGGCTGCAGGAGGTGTCGAGCGGCGTTATTTTTTTTTGCGGTTTGCCTTTTTTTTTCTTTTTTTTTTTTTTGGAACCG
CGGTTGTTTAAAAGCCTGAGGGAACCTGGAGAGGGGCTCCCACTCCCTACCCTCTTTCCTCCGAGTTTGTGACTCCGAGATGGACAAAGT
GTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAG
AAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAACATGATGTTCA
AAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAG
AACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGGACTATGATTCA
ACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGG
ATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGAACACCTGAAGGATAA
ATTGGAAGAATACATGGCCCGATTTTCCAAAGTGAGGATTGTTCGCACCAAGAAAAGAGAAGGACTCATCCGGACCCGTCTCCTGGGGGC
ATCTATGGCCAGAGGAGAAGTCCTGACATTCCTGGACTCCCACTGCGAGGTCAATGTGAACTGGCTGCCCCCACTCCTCAACCAAATTGC
ACTAAACCACAAAACCATCGTGTGTCCCATGATCGATGTCATTGACCACAATCACTTCGGGTATGAGGCACAAGCTGGGGATGCCATGCG
AGGAGCCTTCGACTGGGAAATGTACTACAAAAGAATCCCCATCCCTCCAGAGCTCCAGAGGGCAGATCCCAGCGACCCTTTTGAGTCTCC
TGTTATGGCTGGAGGTCTCTTTGCTGTGGATCGGAAATGGTTTTGGGAATTGGGTGGCTATGATCCAGGTTTAGAAATCTGGGGAGGAGA
ACAGTATGAAATCTCTTTTAAGGTTTGGATGTGTGGAGGAGAAATGTTTGATGTTCCATGTTCTAGAGTTGGTCATATCTACAGGAAGTA
CGTTCCATACAAAGTTCCATCTGGGACAAGCCTGGCAAGAAACCTGAAGCGGGTAGCTGAGACCTGGATGGATGAATTTGCCGAGTACAT
TTACCAGCGGCGGCCGGAGTACAGGCATCTCTCCACGGGGGACATCTCTGCCCAGAAGGAGCTGCGCAAGCAGCTCAAGTGCAAGGACTT
CAAATGGTTCATGGCTGCTGTGGCCTGGGACGTGCCTAAATACTACCCTCCAGTGGAGCCCCCGCCTGCTGCCTGGGGGGAGATCCGAAA
TGTGGCAGCAAATCTCTGTGTGGACAGCAAGCATGGAGCCACCGGAACAGAGCTGAGGCTGGACATCTGTGTCAAGGATGGTTCTGAAAG
AACATGGTCTCATGAACAGCTTTTTACCTTTGGATGGAGAGAAGATATTCGACCCGGTGAGCCACTGCATACCCGGAAATTCTGCTTTGA
TGCGATCTCACACAACAGCCCCGTTACACTCTATGACTGTCATGGCATGAAGGGGAACCAGCTCTGGGGATACCGGAAGGACAGAACATT
ATTCCATCCTGTGAGCAACAGCTGCATGGATTGCAACCCCGCAGAGAAGAAGATTTTCATGGCCAGATGTGACCCTCTCTCTGAGACTCA

>13418_13418_2_CBR4-GALNTL6_CBR4_chr4_169923222_ENST00000306193_GALNTL6_chr4_173730512_ENST00000508122_length(amino acids)=614AA_BP=196
MERGSHSLPSFLRVCDSEMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEK
HLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRAL
AKEVARKKIRVNVVAPEHLKDKLEEYMARFSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVC
PMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKV
WMCGGEMFDVPCSRVGHIYRKYVPYKVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVA
WDVPKYYPPVEPPPAAWGEIRNVAANLCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCFDAISHNSPV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CBR4-GALNTL6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CBR4-GALNTL6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CBR4-GALNTL6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source