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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACO2-PRR5 (FusionGDB2 ID:1351)

Fusion Gene Summary for ACO2-PRR5

check button Fusion gene summary
Fusion gene informationFusion gene name: ACO2-PRR5
Fusion gene ID: 1351
HgeneTgene
Gene symbol

ACO2

PRR5

Gene ID

50

55615

Gene nameaconitase 2proline rich 5
SynonymsACONM|HEL-S-284|ICRD|OCA8|OPA9FLJ20185k|PP610|PROTOR-1|PROTOR1
Cytomap

22q13.2

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionaconitate hydratase, mitochondrialaconitase 2, mitochondrialcitrate hydro-lyaseepididymis secretory sperm binding protein Li 284mitochondrial aconitaseproline-rich protein 5Rho GTPase activating protein 8proline rich 5 (renal)protein observed with Rictor-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000216254, ENST00000396512, 
ENST00000466237, 		ENST00000477331, 
ENST00000006251, ENST00000336985, 
ENST00000403581, 
Fusion gene scores* DoF score17 X 8 X 10=13603 X 5 X 3=45
# samples 225
** MAII scorelog2(22/1360*10)=-2.62803122261304
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ACO2 [Title/Abstract] AND PRR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACO2(41895866)-PRR5(45098372), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACO2

GO:0006099

tricarboxylic acid cycle

9630632

HgeneACO2

GO:0006101

citrate metabolic process

9630632


check buttonFusion gene breakpoints across ACO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

-PRR5chr22

45098372

+
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

+PRR5chr22

45098372

+
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

+PRR5chr22

45110471

+
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

+PRR5chr22

45121124

+
ChimerDB4UCECTCGA-AJ-A3EMACO2chr22

41895866

+PRR5chr22

45110470

+
ChimerDB4UCECTCGA-AJ-A3EMACO2chr22

41895866

+PRR5chr22

45121123

+


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Fusion Gene ORF analysis for ACO2-PRR5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000216254ENST00000477331ACO2chr22

41895866

+PRR5chr22

45110471

+
5CDS-3UTRENST00000216254ENST00000477331ACO2chr22

41895866

+PRR5chr22

45110470

+
5CDS-3UTRENST00000396512ENST00000477331ACO2chr22

41895866

+PRR5chr22

45110471

+
5CDS-3UTRENST00000396512ENST00000477331ACO2chr22

41895866

+PRR5chr22

45110470

+
5CDS-5UTRENST00000216254ENST00000006251ACO2chr22

41895866

+PRR5chr22

45098372

+
5CDS-5UTRENST00000216254ENST00000336985ACO2chr22

41895866

+PRR5chr22

45098372

+
5CDS-5UTRENST00000216254ENST00000403581ACO2chr22

41895866

+PRR5chr22

45098372

+
5CDS-5UTRENST00000396512ENST00000006251ACO2chr22

41895866

+PRR5chr22

45098372

+
5CDS-5UTRENST00000396512ENST00000336985ACO2chr22

41895866

+PRR5chr22

45098372

+
5CDS-5UTRENST00000396512ENST00000403581ACO2chr22

41895866

+PRR5chr22

45098372

+
5CDS-intronENST00000216254ENST00000477331ACO2chr22

41895866

+PRR5chr22

45098372

+
5CDS-intronENST00000216254ENST00000477331ACO2chr22

41895866

+PRR5chr22

45121124

+
5CDS-intronENST00000216254ENST00000477331ACO2chr22

41895866

+PRR5chr22

45121123

+
5CDS-intronENST00000396512ENST00000477331ACO2chr22

41895866

+PRR5chr22

45098372

+
5CDS-intronENST00000396512ENST00000477331ACO2chr22

41895866

+PRR5chr22

45121124

+
5CDS-intronENST00000396512ENST00000477331ACO2chr22

41895866

+PRR5chr22

45121123

+
In-frameENST00000216254ENST00000006251ACO2chr22

41895866

+PRR5chr22

45110471

+
In-frameENST00000216254ENST00000006251ACO2chr22

41895866

+PRR5chr22

45121124

+
In-frameENST00000216254ENST00000006251ACO2chr22

41895866

+PRR5chr22

45110470

+
In-frameENST00000216254ENST00000006251ACO2chr22

41895866

+PRR5chr22

45121123

+
In-frameENST00000216254ENST00000336985ACO2chr22

41895866

+PRR5chr22

45110471

+
In-frameENST00000216254ENST00000336985ACO2chr22

41895866

+PRR5chr22

45121124

+
In-frameENST00000216254ENST00000336985ACO2chr22

41895866

+PRR5chr22

45110470

+
In-frameENST00000216254ENST00000336985ACO2chr22

41895866

+PRR5chr22

45121123

+
In-frameENST00000216254ENST00000403581ACO2chr22

41895866

+PRR5chr22

45110471

+
In-frameENST00000216254ENST00000403581ACO2chr22

41895866

+PRR5chr22

45121124

+
In-frameENST00000216254ENST00000403581ACO2chr22

41895866

+PRR5chr22

45110470

+
In-frameENST00000216254ENST00000403581ACO2chr22

41895866

+PRR5chr22

45121123

+
In-frameENST00000396512ENST00000006251ACO2chr22

41895866

+PRR5chr22

45110471

+
In-frameENST00000396512ENST00000006251ACO2chr22

41895866

+PRR5chr22

45121124

+
In-frameENST00000396512ENST00000006251ACO2chr22

41895866

+PRR5chr22

45110470

+
In-frameENST00000396512ENST00000006251ACO2chr22

41895866

+PRR5chr22

45121123

+
In-frameENST00000396512ENST00000336985ACO2chr22

41895866

+PRR5chr22

45110471

+
In-frameENST00000396512ENST00000336985ACO2chr22

41895866

+PRR5chr22

45121124

+
In-frameENST00000396512ENST00000336985ACO2chr22

41895866

+PRR5chr22

45110470

+
In-frameENST00000396512ENST00000336985ACO2chr22

41895866

+PRR5chr22

45121123

+
In-frameENST00000396512ENST00000403581ACO2chr22

41895866

+PRR5chr22

45110471

+
In-frameENST00000396512ENST00000403581ACO2chr22

41895866

+PRR5chr22

45121124

+
In-frameENST00000396512ENST00000403581ACO2chr22

41895866

+PRR5chr22

45110470

+
In-frameENST00000396512ENST00000403581ACO2chr22

41895866

+PRR5chr22

45121123

+
intron-3CDSENST00000466237ENST00000006251ACO2chr22

41895866

+PRR5chr22

45110471

+
intron-3CDSENST00000466237ENST00000006251ACO2chr22

41895866

+PRR5chr22

45121124

+
intron-3CDSENST00000466237ENST00000006251ACO2chr22

41895866

+PRR5chr22

45110470

+
intron-3CDSENST00000466237ENST00000006251ACO2chr22

41895866

+PRR5chr22

45121123

+
intron-3CDSENST00000466237ENST00000336985ACO2chr22

41895866

+PRR5chr22

45110471

+
intron-3CDSENST00000466237ENST00000336985ACO2chr22

41895866

+PRR5chr22

45121124

+
intron-3CDSENST00000466237ENST00000336985ACO2chr22

41895866

+PRR5chr22

45110470

+
intron-3CDSENST00000466237ENST00000336985ACO2chr22

41895866

+PRR5chr22

45121123

+
intron-3CDSENST00000466237ENST00000403581ACO2chr22

41895866

+PRR5chr22

45110471

+
intron-3CDSENST00000466237ENST00000403581ACO2chr22

41895866

+PRR5chr22

45121124

+
intron-3CDSENST00000466237ENST00000403581ACO2chr22

41895866

+PRR5chr22

45110470

+
intron-3CDSENST00000466237ENST00000403581ACO2chr22

41895866

+PRR5chr22

45121123

+
intron-3UTRENST00000466237ENST00000477331ACO2chr22

41895866

+PRR5chr22

45110471

+
intron-3UTRENST00000466237ENST00000477331ACO2chr22

41895866

+PRR5chr22

45110470

+
intron-5UTRENST00000466237ENST00000006251ACO2chr22

41895866

+PRR5chr22

45098372

+
intron-5UTRENST00000466237ENST00000336985ACO2chr22

41895866

+PRR5chr22

45098372

+
intron-5UTRENST00000466237ENST00000403581ACO2chr22

41895866

+PRR5chr22

45098372

+
intron-intronENST00000466237ENST00000477331ACO2chr22

41895866

+PRR5chr22

45098372

+
intron-intronENST00000466237ENST00000477331ACO2chr22

41895866

+PRR5chr22

45121124

+
intron-intronENST00000466237ENST00000477331ACO2chr22

41895866

+PRR5chr22

45121123

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000216254ACO2chr2241895866+ENST00000006251PRR5chr2245121123+158019571146379
ENST00000216254ACO2chr2241895866+ENST00000403581PRR5chr2245121123+158119571146379
ENST00000216254ACO2chr2241895866+ENST00000336985PRR5chr2245121123+158119571146379
ENST00000396512ACO2chr2241895866+ENST00000006251PRR5chr2245121123+157519021141379
ENST00000396512ACO2chr2241895866+ENST00000403581PRR5chr2245121123+157619021141379
ENST00000396512ACO2chr2241895866+ENST00000336985PRR5chr2245121123+157619021141379
ENST00000216254ACO2chr2241895866+ENST00000006251PRR5chr2245110470+166119571227406
ENST00000216254ACO2chr2241895866+ENST00000403581PRR5chr2245110470+166219571227406
ENST00000216254ACO2chr2241895866+ENST00000336985PRR5chr2245110470+166219571227406
ENST00000396512ACO2chr2241895866+ENST00000006251PRR5chr2245110470+165619021222406
ENST00000396512ACO2chr2241895866+ENST00000403581PRR5chr2245110470+165719021222406
ENST00000396512ACO2chr2241895866+ENST00000336985PRR5chr2245110470+165719021222406
ENST00000216254ACO2chr2241895866+ENST00000006251PRR5chr2245110471+166119571227406
ENST00000216254ACO2chr2241895866+ENST00000403581PRR5chr2245110471+166219571227406
ENST00000216254ACO2chr2241895866+ENST00000336985PRR5chr2245110471+166219571227406
ENST00000396512ACO2chr2241895866+ENST00000006251PRR5chr2245110471+165619021222406
ENST00000396512ACO2chr2241895866+ENST00000403581PRR5chr2245110471+165719021222406
ENST00000396512ACO2chr2241895866+ENST00000336985PRR5chr2245110471+165719021222406
ENST00000216254ACO2chr2241895866+ENST00000006251PRR5chr2245121124+158019571146379
ENST00000216254ACO2chr2241895866+ENST00000403581PRR5chr2245121124+158119571146379
ENST00000216254ACO2chr2241895866+ENST00000336985PRR5chr2245121124+158119571146379
ENST00000396512ACO2chr2241895866+ENST00000006251PRR5chr2245121124+157519021141379
ENST00000396512ACO2chr2241895866+ENST00000403581PRR5chr2245121124+157619021141379
ENST00000396512ACO2chr2241895866+ENST00000336985PRR5chr2245121124+157619021141379

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000216254ENST00000006251ACO2chr2241895866+PRR5chr2245121123+0.0079030920.9920969
ENST00000216254ENST00000403581ACO2chr2241895866+PRR5chr2245121123+0.0078465440.99215347
ENST00000216254ENST00000336985ACO2chr2241895866+PRR5chr2245121123+0.0078465440.99215347
ENST00000396512ENST00000006251ACO2chr2241895866+PRR5chr2245121123+0.0078574580.99214256
ENST00000396512ENST00000403581ACO2chr2241895866+PRR5chr2245121123+0.0078035010.99219656
ENST00000396512ENST00000336985ACO2chr2241895866+PRR5chr2245121123+0.0078035010.99219656
ENST00000216254ENST00000006251ACO2chr2241895866+PRR5chr2245110470+0.0053808610.99461913
ENST00000216254ENST00000403581ACO2chr2241895866+PRR5chr2245110470+0.0053554770.9946445
ENST00000216254ENST00000336985ACO2chr2241895866+PRR5chr2245110470+0.0053554770.9946445
ENST00000396512ENST00000006251ACO2chr2241895866+PRR5chr2245110470+0.0053394870.99466056
ENST00000396512ENST00000403581ACO2chr2241895866+PRR5chr2245110470+0.0053127070.9946873
ENST00000396512ENST00000336985ACO2chr2241895866+PRR5chr2245110470+0.0053127070.9946873
ENST00000216254ENST00000006251ACO2chr2241895866+PRR5chr2245110471+0.0053808610.99461913
ENST00000216254ENST00000403581ACO2chr2241895866+PRR5chr2245110471+0.0053554770.9946445
ENST00000216254ENST00000336985ACO2chr2241895866+PRR5chr2245110471+0.0053554770.9946445
ENST00000396512ENST00000006251ACO2chr2241895866+PRR5chr2245110471+0.0053394870.99466056
ENST00000396512ENST00000403581ACO2chr2241895866+PRR5chr2245110471+0.0053127070.9946873
ENST00000396512ENST00000336985ACO2chr2241895866+PRR5chr2245110471+0.0053127070.9946873
ENST00000216254ENST00000006251ACO2chr2241895866+PRR5chr2245121124+0.0079030920.9920969
ENST00000216254ENST00000403581ACO2chr2241895866+PRR5chr2245121124+0.0078465440.99215347
ENST00000216254ENST00000336985ACO2chr2241895866+PRR5chr2245121124+0.0078465440.99215347
ENST00000396512ENST00000006251ACO2chr2241895866+PRR5chr2245121124+0.0078574580.99214256
ENST00000396512ENST00000403581ACO2chr2241895866+PRR5chr2245121124+0.0078035010.99219656
ENST00000396512ENST00000336985ACO2chr2241895866+PRR5chr2245121124+0.0078035010.99219656

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Fusion Genomic Features for ACO2-PRR5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACO2chr2241895866+PRR5chr2245098371+3.47E-070.99999964
ACO2chr2241895866+PRR5chr2245121123+5.16E-081
ACO2chr2241895866+PRR5chr2245110470+1.64E-111
ACO2chr2241895866+PRR5chr2245110470+1.64E-111
ACO2chr2241895866+PRR5chr2245121123+5.16E-081
ACO2chr2241895866+PRR5chr2245098371+3.47E-070.99999964
ACO2chr2241895866+PRR5chr2245121123+5.16E-081
ACO2chr2241895866+PRR5chr2245110470+1.64E-111
ACO2chr2241895866+PRR5chr2245110470+1.64E-111
ACO2chr2241895866+PRR5chr2245121123+5.16E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACO2-PRR5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41895866/chr22:45098372)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACO2chr22:41895866chr22:45110470ENST00000216254+218192_19457781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45110470ENST00000216254+218670_67157781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45110471ENST00000216254+218192_19457781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45110471ENST00000216254+218670_67157781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45121123ENST00000216254+218192_19457781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45121123ENST00000216254+218670_67157781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45121124ENST00000216254+218192_19457781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45121124ENST00000216254+218670_67157781.0RegionSubstrate binding
TgenePRR5chr22:41895866chr22:45110470ENST000000062511924_2735380.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45110470ENST000003369850824_2744389.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45110470ENST0000040358121024_2767412.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45110471ENST000000062511924_2735380.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45110471ENST000003369850824_2744389.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45110471ENST0000040358121024_2767412.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121123ENST000000062512924_2762380.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121123ENST000003369851824_2771389.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121123ENST0000040358131024_2794412.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121124ENST000000062512924_2762380.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121124ENST000003369851824_2771389.0Compositional biasNote=Poly-Ala
TgenePRR5chr22:41895866chr22:45121124ENST0000040358131024_2794412.0Compositional biasNote=Poly-Ala


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Fusion Gene Sequence for ACO2-PRR5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1351_1351_1_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110470_ENST00000006251_length(transcript)=1661nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGG
CGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCG
GGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCT
GCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGT
GAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTC
CAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAG
CGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGT
GCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAG
GCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTC
CCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCT
GCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGG
CCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGAC
ACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTC
ACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTC
GGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCC
CACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGG

>1351_1351_1_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110470_ENST00000006251_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_2_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110470_ENST00000336985_length(transcript)=1662nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGG
CGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCG
GGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCT
GCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGT
GAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTC
CAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAG
CGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGT
GCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAG
GCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTC
CCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCT
GCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGG
CCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGAC
ACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTC
ACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTC
GGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCC
CACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGG

>1351_1351_2_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110470_ENST00000336985_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_3_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110470_ENST00000403581_length(transcript)=1662nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGG
CGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCG
GGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCT
GCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGT
GAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTC
CAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAG
CGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGT
GCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAG
GCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTC
CCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCT
GCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGG
CCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGAC
ACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTC
ACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTC
GGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCC
CACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGG

>1351_1351_3_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110470_ENST00000403581_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_4_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110471_ENST00000006251_length(transcript)=1661nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGG
CGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCG
GGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCT
GCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGT
GAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTC
CAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAG
CGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGT
GCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAG
GCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTC
CCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCT
GCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGG
CCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGAC
ACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTC
ACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTC
GGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCC
CACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGG

>1351_1351_4_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110471_ENST00000006251_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_5_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110471_ENST00000336985_length(transcript)=1662nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGG
CGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCG
GGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCT
GCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGT
GAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTC
CAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAG
CGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGT
GCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAG
GCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTC
CCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCT
GCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGG
CCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGAC
ACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTC
ACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTC
GGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCC
CACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGG

>1351_1351_5_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110471_ENST00000336985_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_6_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110471_ENST00000403581_length(transcript)=1662nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGG
CGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCG
GGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCT
GCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGT
GAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTC
CAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAG
CGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGT
GCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAG
GCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTC
CCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCT
GCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGG
CCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGAC
ACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTC
ACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTC
GGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCC
CACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGG

>1351_1351_6_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45110471_ENST00000403581_length(amino acids)=406AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_7_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121123_ENST00000006251_length(transcript)=1580nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGT
GATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCT
GCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCAC
CCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGT
ACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCT
CCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAA
CCCTGTGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAG
CATCCGCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTT
CAGGTCCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCG
CAGCTCCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTT
TGGCCGGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTT
TTTACTGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATC
GGCCTCGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGC
ATCTGAGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCC
ACACCTGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGC

>1351_1351_7_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121123_ENST00000006251_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------
>1351_1351_8_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121123_ENST00000336985_length(transcript)=1581nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGT
GATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCT
GCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCAC
CCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGT
ACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCT
CCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAA
CCCTGTGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAG
CATCCGCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTT
CAGGTCCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCG
CAGCTCCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTT
TGGCCGGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTT
TTTACTGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATC
GGCCTCGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGC
ATCTGAGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCC
ACACCTGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGC

>1351_1351_8_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121123_ENST00000336985_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------
>1351_1351_9_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121123_ENST00000403581_length(transcript)=1581nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGT
GATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCT
GCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCAC
CCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGT
ACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCT
CCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAA
CCCTGTGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAG
CATCCGCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTT
CAGGTCCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCG
CAGCTCCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTT
TGGCCGGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTT
TTTACTGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATC
GGCCTCGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGC
ATCTGAGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCC
ACACCTGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGC

>1351_1351_9_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121123_ENST00000403581_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------
>1351_1351_10_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121124_ENST00000006251_length(transcript)=1580nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGT
GATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCT
GCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCAC
CCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGT
ACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCT
CCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAA
CCCTGTGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAG
CATCCGCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTT
CAGGTCCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCG
CAGCTCCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTT
TGGCCGGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTT
TTTACTGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATC
GGCCTCGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGC
ATCTGAGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCC
ACACCTGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGC

>1351_1351_10_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121124_ENST00000006251_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------
>1351_1351_11_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121124_ENST00000336985_length(transcript)=1581nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGT
GATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCT
GCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCAC
CCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGT
ACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCT
CCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAA
CCCTGTGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAG
CATCCGCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTT
CAGGTCCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCG
CAGCTCCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTT
TGGCCGGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTT
TTTACTGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATC
GGCCTCGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGC
ATCTGAGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCC
ACACCTGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGC

>1351_1351_11_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121124_ENST00000336985_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------
>1351_1351_12_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121124_ENST00000403581_length(transcript)=1581nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGT
GATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCT
GCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCAC
CCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGT
ACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCT
CCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAA
CCCTGTGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAG
CATCCGCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTT
CAGGTCCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCG
CAGCTCCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTT
TGGCCGGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTT
TTTACTGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATC
GGCCTCGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGC
ATCTGAGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCC
ACACCTGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGC

>1351_1351_12_ACO2-PRR5_ACO2_chr22_41895866_ENST00000216254_PRR5_chr22_45121124_ENST00000403581_length(amino acids)=379AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------
>1351_1351_13_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110470_ENST00000006251_length(transcript)=1656nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCC
GGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCGGGACA
AGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGG
CCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGTGAAGC
TAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGG
GCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAGCGAGG
GGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGTGCGCT
CCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAGGCACT
CTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTCCCCGG
CGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCTGCCCC
GCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGGCCGGG
GCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGACACGTC
CCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTCACTGG
CCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTCGGCGT
TTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCCCACAG
AGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGGCCATG

>1351_1351_13_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110470_ENST00000006251_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_14_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110470_ENST00000336985_length(transcript)=1657nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCC
GGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCGGGACA
AGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGG
CCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGTGAAGC
TAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGG
GCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAGCGAGG
GGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGTGCGCT
CCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAGGCACT
CTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTCCCCGG
CGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCTGCCCC
GCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGGCCGGG
GCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGACACGTC
CCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTCACTGG
CCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTCGGCGT
TTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCCCACAG
AGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGGCCATG

>1351_1351_14_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110470_ENST00000336985_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_15_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110470_ENST00000403581_length(transcript)=1657nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCC
GGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCGGGACA
AGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGG
CCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGTGAAGC
TAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGG
GCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAGCGAGG
GGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGTGCGCT
CCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAGGCACT
CTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTCCCCGG
CGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCTGCCCC
GCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGGCCGGG
GCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGACACGTC
CCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTCACTGG
CCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTCGGCGT
TTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCCCACAG
AGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGGCCATG

>1351_1351_15_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110470_ENST00000403581_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_16_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110471_ENST00000006251_length(transcript)=1656nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCC
GGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCGGGACA
AGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGG
CCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGTGAAGC
TAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGG
GCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAGCGAGG
GGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGTGCGCT
CCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAGGCACT
CTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTCCCCGG
CGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCTGCCCC
GCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGGCCGGG
GCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGACACGTC
CCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTCACTGG
CCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTCGGCGT
TTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCCCACAG
AGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGGCCATG

>1351_1351_16_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110471_ENST00000006251_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_17_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110471_ENST00000336985_length(transcript)=1657nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCC
GGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCGGGACA
AGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGG
CCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGTGAAGC
TAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGG
GCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAGCGAGG
GGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGTGCGCT
CCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAGGCACT
CTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTCCCCGG
CGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCTGCCCC
GCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGGCCGGG
GCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGACACGTC
CCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTCACTGG
CCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTCGGCGT
TTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCCCACAG
AGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGGCCATG

>1351_1351_17_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110471_ENST00000336985_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_18_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110471_ENST00000403581_length(transcript)=1657nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCC
GGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCGGGACA
AGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGG
CCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGTGAAGC
TAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGG
GCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAGCGAGG
GGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTGTGGTGCGCT
CCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCCGCAGGCACT
CTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGTCCTCCCCGG
CGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCTCCCTGCCCC
GCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCCGGGGCCGGG
GCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTACTGACACGTC
CCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCTCGTCACTGG
CCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTGAGTCGGCGT
TTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACCTGCCCACAG
AGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGGGTGGCCATG

>1351_1351_18_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45110471_ENST00000403581_length(amino acids)=406AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRS
KSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPR

--------------------------------------------------------------
>1351_1351_19_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121123_ENST00000006251_length(transcript)=1575nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCC
TTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCA
TGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCA
GTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATG
AGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACT
CCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTG
TGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCC
GCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGT
CCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCT
CCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCC
GGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTAC
TGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCT
CGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTG
AGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACC
TGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGG

>1351_1351_19_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121123_ENST00000006251_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------
>1351_1351_20_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121123_ENST00000336985_length(transcript)=1576nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCC
TTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCA
TGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCA
GTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATG
AGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACT
CCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTG
TGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCC
GCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGT
CCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCT
CCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCC
GGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTAC
TGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCT
CGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTG
AGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACC
TGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGG

>1351_1351_20_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121123_ENST00000336985_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------
>1351_1351_21_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121123_ENST00000403581_length(transcript)=1576nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCC
TTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCA
TGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCA
GTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATG
AGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACT
CCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTG
TGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCC
GCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGT
CCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCT
CCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCC
GGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTAC
TGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCT
CGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTG
AGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACC
TGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGG

>1351_1351_21_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121123_ENST00000403581_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------
>1351_1351_22_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121124_ENST00000006251_length(transcript)=1575nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCC
TTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCA
TGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCA
GTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATG
AGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACT
CCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTG
TGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCC
GCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGT
CCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCT
CCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCC
GGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTAC
TGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCT
CGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTG
AGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACC
TGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGG

>1351_1351_22_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121124_ENST00000006251_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------
>1351_1351_23_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121124_ENST00000336985_length(transcript)=1576nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCC
TTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCA
TGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCA
GTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATG
AGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACT
CCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTG
TGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCC
GCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGT
CCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCT
CCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCC
GGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTAC
TGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCT
CGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTG
AGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACC
TGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGG

>1351_1351_23_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121124_ENST00000336985_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------
>1351_1351_24_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121124_ENST00000403581_length(transcript)=1576nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCC
TTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCA
TGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCA
GTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATG
AGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACT
CCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAAAAGCGCCTCCTCCGCCGCTCCCGCTCGGGGGACGTGCTGGCCAAGAACCCTG
TGGTGCGCTCCAAGAGCTACAACACGCCTCTGCTGAACCCCGTGCAGGAGCACGAGGCGGAGGGCGCGGCGGCCGGCGGTACCAGCATCC
GCAGGCACTCTGTGTCGGAGATGACGTCCTGCCCCGAGCCTCAGGGCTTCTCCGACCCGCCCGGCCAGGGCCCCACCGGGACCTTCAGGT
CCTCCCCGGCGCCCCACTCAGGGCCCTGCCCCAGCAGACTGTACCCCACGACCCAGCCCCCTGAGCAGGGCTTGGATCCCACCCGCAGCT
CCCTGCCCCGCTCCAGCCCGGAGAACCTGGTGGACCAGATCCTGGAGTCCGTGGACTCGGATTCTGAAGGGATTTTCATTGACTTTGGCC
GGGGCCGGGGCTCTGGCATGTCCGACTTGGAGGGCTCTGGGGGCCGGCAGAGTGTCGTGTGAGGCCTCACAGCTGGCCTTGAGTTTTTAC
TGACACGTCCCTGTGTGCGGGGGTGTCCATGTGGCGTGTGTGTGAGTGAGACTTTTTTACTGCGTCCCGTCCCGCCAGCCCTATCGGCCT
CGTCACTGGCCTTGGTCACTTTGTATTTCTGTCTTGGTTGGAAATACCATCAGCCTTCCTTGCTCGGCCCAGGTCTGTTTCAGGCATCTG
AGTCGGCGTTTACCCAGGGGCCGGGCCAGAGACGGGGGTCGGCCGCTCGCTCCCACGCTCCTCCTGCCCCAGCCCTCTGGTGTCCACACC
TGCCCACAGAGAATGTAAACCCAGTGGGCTCTGCCCACGCCGGGCCCCAAAGTGACCAGACTCCAGCACACCTGTCTCCTCCTGCCTGGG

>1351_1351_24_ACO2-PRR5_ACO2_chr22_41895866_ENST00000396512_PRR5_chr22_45121124_ENST00000403581_length(amino acids)=379AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIR
RHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACO2-PRR5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePRR5chr22:41895866chr22:45110470ENST0000000625119188_21835.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45110470ENST0000033698508188_21844.666666666666664389.0RICTOR
TgenePRR5chr22:41895866chr22:45110470ENST00000403581210188_21867.66666666666667412.0RICTOR
TgenePRR5chr22:41895866chr22:45110471ENST0000000625119188_21835.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45110471ENST0000033698508188_21844.666666666666664389.0RICTOR
TgenePRR5chr22:41895866chr22:45110471ENST00000403581210188_21867.66666666666667412.0RICTOR
TgenePRR5chr22:41895866chr22:45121123ENST0000000625129188_21862.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45121123ENST0000033698518188_21871.66666666666667389.0RICTOR
TgenePRR5chr22:41895866chr22:45121123ENST00000403581310188_21894.66666666666667412.0RICTOR
TgenePRR5chr22:41895866chr22:45121124ENST0000000625129188_21862.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45121124ENST0000033698518188_21871.66666666666667389.0RICTOR
TgenePRR5chr22:41895866chr22:45121124ENST00000403581310188_21894.66666666666667412.0RICTOR


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePRR5chr22:41895866chr22:45110470ENST000000062511910_9535.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45110470ENST000003369850810_9544.666666666666664389.0RICTOR
TgenePRR5chr22:41895866chr22:45110470ENST0000040358121010_9567.66666666666667412.0RICTOR
TgenePRR5chr22:41895866chr22:45110471ENST000000062511910_9535.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45110471ENST000003369850810_9544.666666666666664389.0RICTOR
TgenePRR5chr22:41895866chr22:45110471ENST0000040358121010_9567.66666666666667412.0RICTOR
TgenePRR5chr22:41895866chr22:45121123ENST000000062512910_9562.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45121123ENST000003369851810_9571.66666666666667389.0RICTOR
TgenePRR5chr22:41895866chr22:45121123ENST0000040358131010_9594.66666666666667412.0RICTOR
TgenePRR5chr22:41895866chr22:45121124ENST000000062512910_9562.666666666666664380.0RICTOR
TgenePRR5chr22:41895866chr22:45121124ENST000003369851810_9571.66666666666667389.0RICTOR
TgenePRR5chr22:41895866chr22:45121124ENST0000040358131010_9594.66666666666667412.0RICTOR


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACO2-PRR5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACO2-PRR5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource