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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCAR1-AMACR (FusionGDB2 ID:13513)

Fusion Gene Summary for CCAR1-AMACR

check button Fusion gene summary
Fusion gene informationFusion gene name: CCAR1-AMACR
Fusion gene ID: 13513
HgeneTgene
Gene symbol

CCAR1

AMACR

Gene ID

55749

23600

Gene namecell division cycle and apoptosis regulator 1alpha-methylacyl-CoA racemase
Synonyms-AMACRD|CBAS4|P504S|RACE|RM
Cytomap

10q21.3

5p13.2

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle and apoptosis regulator protein 1cell cycle and apoptosis regulatory protein 1death inducer with SAP domainalpha-methylacyl-CoA racemase2-methylacyl-CoA racemase
Modification date2020031320200313
UniProtAcc

Q8IX12

Q9UHK6

Ensembl transtripts involved in fusion geneENST00000265872, ENST00000535016, 
ENST00000543719, ENST00000483264, 
ENST00000382068, ENST00000382085, 
ENST00000426255, ENST00000441713, 
ENST00000502637, ENST00000512079, 
ENST00000514195, ENST00000335606, 
ENST00000382072, 
Fusion gene scores* DoF score13 X 11 X 8=114428 X 3 X 4=336
# samples 1723
** MAII scorelog2(17/1144*10)=-2.75048040064069
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/336*10)=-0.546827371834385
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCAR1 [Title/Abstract] AND AMACR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCAR1(70532856)-AMACR(34006004), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCAR1

GO:0043065

positive regulation of apoptotic process

12816952

TgeneAMACR

GO:0008206

bile acid metabolic process

10655068


check buttonFusion gene breakpoints across CCAR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AMACR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-6348CCAR1chr10

70532856

+AMACRchr5

34006004

-


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Fusion Gene ORF analysis for CCAR1-AMACR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265872ENST00000382068CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000265872ENST00000382085CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000265872ENST00000426255CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000265872ENST00000441713CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000265872ENST00000502637CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000265872ENST00000512079CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000265872ENST00000514195CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000535016ENST00000382068CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000535016ENST00000382085CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000535016ENST00000426255CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000535016ENST00000441713CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000535016ENST00000502637CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000535016ENST00000512079CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000535016ENST00000514195CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000543719ENST00000382068CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000543719ENST00000382085CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000543719ENST00000426255CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000543719ENST00000441713CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000543719ENST00000502637CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000543719ENST00000512079CCAR1chr10

70532856

+AMACRchr5

34006004

-
5CDS-5UTRENST00000543719ENST00000514195CCAR1chr10

70532856

+AMACRchr5

34006004

-
In-frameENST00000265872ENST00000335606CCAR1chr10

70532856

+AMACRchr5

34006004

-
In-frameENST00000265872ENST00000382072CCAR1chr10

70532856

+AMACRchr5

34006004

-
In-frameENST00000535016ENST00000335606CCAR1chr10

70532856

+AMACRchr5

34006004

-
In-frameENST00000535016ENST00000382072CCAR1chr10

70532856

+AMACRchr5

34006004

-
In-frameENST00000543719ENST00000335606CCAR1chr10

70532856

+AMACRchr5

34006004

-
In-frameENST00000543719ENST00000382072CCAR1chr10

70532856

+AMACRchr5

34006004

-
intron-3CDSENST00000483264ENST00000335606CCAR1chr10

70532856

+AMACRchr5

34006004

-
intron-3CDSENST00000483264ENST00000382072CCAR1chr10

70532856

+AMACRchr5

34006004

-
intron-5UTRENST00000483264ENST00000382068CCAR1chr10

70532856

+AMACRchr5

34006004

-
intron-5UTRENST00000483264ENST00000382085CCAR1chr10

70532856

+AMACRchr5

34006004

-
intron-5UTRENST00000483264ENST00000426255CCAR1chr10

70532856

+AMACRchr5

34006004

-
intron-5UTRENST00000483264ENST00000441713CCAR1chr10

70532856

+AMACRchr5

34006004

-
intron-5UTRENST00000483264ENST00000502637CCAR1chr10

70532856

+AMACRchr5

34006004

-
intron-5UTRENST00000483264ENST00000512079CCAR1chr10

70532856

+AMACRchr5

34006004

-
intron-5UTRENST00000483264ENST00000514195CCAR1chr10

70532856

+AMACRchr5

34006004

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535016CCAR1chr1070532856+ENST00000335606AMACRchr534006004-6541272411936251168
ENST00000535016CCAR1chr1070532856+ENST00000382072AMACRchr534006004-538427241193073984
ENST00000265872CCAR1chr1070532856+ENST00000335606AMACRchr534006004-6586276911936701183
ENST00000265872CCAR1chr1070532856+ENST00000382072AMACRchr534006004-542927691193118999
ENST00000543719CCAR1chr1070532856+ENST00000335606AMACRchr534006004-6535271811336191168
ENST00000543719CCAR1chr1070532856+ENST00000382072AMACRchr534006004-537827181133067984

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535016ENST00000335606CCAR1chr1070532856+AMACRchr534006004-0.0004555470.99954444
ENST00000535016ENST00000382072CCAR1chr1070532856+AMACRchr534006004-0.0004437990.9995561
ENST00000265872ENST00000335606CCAR1chr1070532856+AMACRchr534006004-0.0004649340.9995351
ENST00000265872ENST00000382072CCAR1chr1070532856+AMACRchr534006004-0.0004422760.9995577
ENST00000543719ENST00000335606CCAR1chr1070532856+AMACRchr534006004-0.0004493520.99955064
ENST00000543719ENST00000382072CCAR1chr1070532856+AMACRchr534006004-0.0004340010.999566

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Fusion Genomic Features for CCAR1-AMACR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCAR1-AMACR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:70532856/chr5:34006004)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCAR1

Q8IX12

AMACR

Q9UHK6

FUNCTION: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}.FUNCTION: Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). {ECO:0000269|PubMed:10655068, ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCAR1chr10:70532856chr5:34006004ENST00000265872+1925594_6188831151.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70532856chr5:34006004ENST00000535016+1824594_6188681136.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70532856chr5:34006004ENST00000543719+1824594_6188681136.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70532856chr5:34006004ENST00000265872+1925293_3618831151.0Compositional biasNote=Arg-rich
HgeneCCAR1chr10:70532856chr5:34006004ENST00000265872+192573_798831151.0Compositional biasNote=Poly-Ala
HgeneCCAR1chr10:70532856chr5:34006004ENST00000535016+1824293_3618681136.0Compositional biasNote=Arg-rich
HgeneCCAR1chr10:70532856chr5:34006004ENST00000535016+182473_798681136.0Compositional biasNote=Poly-Ala
HgeneCCAR1chr10:70532856chr5:34006004ENST00000543719+1824293_3618681136.0Compositional biasNote=Arg-rich
HgeneCCAR1chr10:70532856chr5:34006004ENST00000543719+182473_798681136.0Compositional biasNote=Poly-Ala
HgeneCCAR1chr10:70532856chr5:34006004ENST00000265872+1925636_6708831151.0DomainSAP
HgeneCCAR1chr10:70532856chr5:34006004ENST00000535016+1824636_6708681136.0DomainSAP
HgeneCCAR1chr10:70532856chr5:34006004ENST00000543719+1824636_6708681136.0DomainSAP
TgeneAMACRchr10:70532856chr5:34006004ENST0000033560605380_38282383.0MotifMicrobody targeting signal
TgeneAMACRchr10:70532856chr5:34006004ENST0000038207204380_38282199.0MotifMicrobody targeting signal
TgeneAMACRchr10:70532856chr5:34006004ENST0000038208506380_38282395.0MotifMicrobody targeting signal
TgeneAMACRchr10:70532856chr5:34006004ENST0000044171304380_38282230.0MotifMicrobody targeting signal
TgeneAMACRchr10:70532856chr5:34006004ENST0000033560605121_12682383.0RegionSubstrate binding
TgeneAMACRchr10:70532856chr5:34006004ENST0000038207204121_12682199.0RegionSubstrate binding
TgeneAMACRchr10:70532856chr5:34006004ENST0000038208506121_12682395.0RegionSubstrate binding
TgeneAMACRchr10:70532856chr5:34006004ENST0000044171304121_12682230.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCAR1chr10:70532856chr5:34006004ENST00000265872+19251033_11148831151.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70532856chr5:34006004ENST00000535016+18241033_11148681136.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70532856chr5:34006004ENST00000543719+18241033_11148681136.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70532856chr5:34006004ENST00000265872+1925673_8898831151.0Compositional biasNote=Glu-rich
HgeneCCAR1chr10:70532856chr5:34006004ENST00000535016+1824673_8898681136.0Compositional biasNote=Glu-rich
HgeneCCAR1chr10:70532856chr5:34006004ENST00000543719+1824673_8898681136.0Compositional biasNote=Glu-rich
TgeneAMACRchr10:70532856chr5:34006004ENST000003356060555_5882383.0RegionSubstrate binding
TgeneAMACRchr10:70532856chr5:34006004ENST000003820720455_5882199.0RegionSubstrate binding
TgeneAMACRchr10:70532856chr5:34006004ENST000003820850655_5882395.0RegionSubstrate binding
TgeneAMACRchr10:70532856chr5:34006004ENST000004417130455_5882230.0RegionSubstrate binding


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Fusion Gene Sequence for CCAR1-AMACR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13513_13513_1_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000265872_AMACR_chr5_34006004_ENST00000335606_length(transcript)=6586nt_BP=2769nt
GAAGTTGGCGCATGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGATCGATGCTATAGAAGACAAA
CAAGGGAAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAG
TATCACAGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAG
CAGGCCTTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTAC
AACAGCAATATTCACAACCTCAGCAGGCCCTGTATAGTGTGCAACAACAGTTACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTG
TTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAGCACAAATAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGC
AAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAAAACTACATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTC
AGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAGTATTGGTTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGA
ATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAACCCAGCCATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTG
CACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGTCACTGCTGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTAT
TGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAGCTGGTTTATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAAC
CGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATGACAGAGGGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTG
AGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGAGGAAACGTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGAT
CACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGTTTTCAAAGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAAC
TAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTGATGCTCAATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCAT
TTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAGTAGAGTCCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATG
CTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTAGTATGGAAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACC
CACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTAAGTTTTTAGTGGGCATGAAAGGCAAGGATGAAGCTATGGCCATTG
GAGGCCACTGGTCTCCTTCGTTGGATGGACCAGACCCAGAAAAAGATCCCTCTGTGTTGATTAAGACTGCTATTCGTTGTTGTAAGGCTC
TGACAGGCATTGATCTAAGTGTGTGCACACAATGGTACCGTTTTGCAGAGATTCGCTACCATCGCCCTGAGGAGACCCACAAGGGGCGTA
CAGTTCCAGCTCATGTGGAGACAGTGGTTTTATTTTTCCCGGATGTTTGGCATTGCCTTCCCACCCGCTCAGAGTGGGAAACCCTCTCCC
GAGGATACAAGCAGCAGCTGGTCGAGAAGCTTCAGGGTGAACGCAAGGAGGCTGATGGAGAACAGGATGAAGAAGAGAAGGATGATGGTG
AAGCTAAAGAAATTTCTACACCTACCCATTGGTCTAAACTTGATCCAAAGACAATGAAGGTAAATGACCTCCGAAAAGAATTAGAAAGTC
GAGCTCTTAGTTCCAAAGGATTAAAATCCCAGTTAATAGCCCGATTGACAAAACAGCTTAAAGTAGAGGAACAAAAAGAAGAACAGAAGG
AGTTAGAGAAATCTGAAAAAGAAGAGGATGAGGATGATGATAGGAAATCTGAAGACGATAAAGAGGAAGAAGAAAGGAAACGTCAAGAGG
AAATAGAACGCCAGCGTCGAGAAAGAAGATATATTTTGCCTGATGAACCGGCCATCATTGTACATCCAAATTGGGCTGCAAAAAGTGGCA
AGTTTGATTGTAGCATCATGTCTTTGAGTGTCCTATTGGACTACAGATTAGAGGATAATAAAGAACATTCATTTGAGGTTTCATTGTTTG
CGGAACTTTTCAACGAAATGCTTCAAAGAGATTTTGGTGTCCGTATATACAAATCATTACTGTCTCTTCCTGAGAAAGAGGACAAAAAAG
AAAAGGATAAAAAAAGCAAAAAAGATGAGAGAAAAGATAAAAAAGAAGAAAGAGATGATGAAACTGATGAACCAAAACCCAAACGGAGAA
AATCAGGCGATGATAAAGATAAAAAAGAAGATAGAGATGAAAGGAAGAAAGAAGATAAAAGAAAAGATGATTCTAAAGATGATGATGAAA
CTGAAGAAGATAACAATCAAGATGAATATGACCCTATGGAAGCAGAAGAAGCTGAGGATGAAGAAGATGGTGTCATGGAGAAACTCCAGC
TGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAG
CTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCC
TGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCA
TTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGAC
AGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGT
TCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGA
AGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTT
TTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTC
TGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCA
GCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCA
AGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTATGCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACC
ACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAA
ACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATTAAGATTCTTGACTTATATT
TTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATATACATTTATTTACACTCTTGATTCTACAATGTAGAAAAT
GAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATC
TCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCT
TCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTG
TATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAG
CAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGAC
TGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCC
CTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGA
TGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCA
TCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCC
AAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAA
ATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTTAATCACAACTACTTACTAAGGAGATGTATGCACCTATTG
GACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTT
TTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTAC
CTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTG
AGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCA
GAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCC
CAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGGACCTCCGTTTCTACGAAATAAAAATAAAAAA
ATTATCCAGGTATGGTGGTGTGTGCCTGTAGTCCTATCTACTCAAGGGTGGGGCAGGAGGATCACTTGAGCCCAGGAATTTGAGGCCACA
GTGAATTAGGATTGCACCACTGCACTCTAGCCCAGGCAACAGAACAAGAACCTGTCTCTAAATAAATAAATAAAAATAATAATAATAAAA
AAGATGTTTTCCCTACAACTCAGACTTTTCATTTGAACTCGGTCCAGCAAGGAAAATATAACCCACTCGAAGTCTTTAAAACAGAGGAAA
TTTAATATAAAGAATTCCACTGGTGACGAAAGAGCAGAGAAGCCCAGAAGATAGTGAGGCAACCCTGATAGGAACATAACTAGGAAGCCA
AGACCACTCCTATGGTTGCAGGGGTGATGGGAAAGCTGGTGTACTTGGACCCAGAAGCCAAAGTTGCTGCACCCACCTTGGAGACATAGA
CACTGGCAGTAATACCTCAGGGAGAAGAAAGAAATCTAGGGAAATATCCTGGCTTCTTTCCTTCTCTCTCTCCCCTAGTCTTCCTACCAG
TGTCTCCCATTAGCCAAATCTACCTAGAAGCCAGAAAACAAGGGAACCCTGGAAATGTAGCCCCATAAGATAAAGAGCACCAAAGGAAAT
AGATCTGAGCAGACAGGCAGCACAAAATGCAGTGTGTATGGTTTATTCACTCAGTAATTCCTTTAGCAAATGTTTATTGAGGATCTACTA
GGTGCCAGGTATCATGATACTTGCTGGGGATACCATAATGAACAAAACAGACCTGTTCTCCGCTCTTGAGGAAATCAAAGACAAACACAG
GATATGGAATAAACCCAGAATTATCTCATTGTAAAATGTGTTAAGTACCACGAGGAGAAATATCAGGGCGATCTGACACAGCTAATGATT
TGAAGAAGGGTGTGACCTGCCACCATTTTAAATCTAGTTATTTCACTCCTGAGCTGTGTGTGTGGAAAACTTGTAGTAAAAAATAGAATG

>13513_13513_1_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000265872_AMACR_chr5_34006004_ENST00000335606_length(amino acids)=1183AA_BP=883
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQQYSQPQQA
LYSVQQQLQQPQQTLLTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTP
QVGDRVLVEATYNPNMPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQ
QPQQKAGLLQPPVRIVSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVP
RYTVQFSKFSLDCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVM
LMASPSMEDLYHKSCALAEDPQELRDGFQHPARLVKFLVGMKGKDEAMAIGGHWSPSLDGPDPEKDPSVLIKTAIRCCKALTGIDLSVCT
QWYRFAEIRYHRPEETHKGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGERKEADGEQDEEEKDDGEAKEISTPTH
WSKLDPKTMKVNDLRKELESRALSSKGLKSQLIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRRERR
YILPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKDKKSKKDE
RKDKKEERDDETDEPKPKRRKSGDDKDKKEDRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEEDGVMEKLQLGPEILQREN
PRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTA
YLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKT
KAEWCQIFDGTDACVTPVLTFEEVVHHDHNKERGSFITSEEQDVSPRPAPLLLNTPAIPSFKRDPFIGEHTEEILEEFGFSREEIYQLNS

--------------------------------------------------------------
>13513_13513_2_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000265872_AMACR_chr5_34006004_ENST00000382072_length(transcript)=5429nt_BP=2769nt
GAAGTTGGCGCATGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGATCGATGCTATAGAAGACAAA
CAAGGGAAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAG
TATCACAGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAG
CAGGCCTTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTAC
AACAGCAATATTCACAACCTCAGCAGGCCCTGTATAGTGTGCAACAACAGTTACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTG
TTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAGCACAAATAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGC
AAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAAAACTACATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTC
AGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAGTATTGGTTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGA
ATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAACCCAGCCATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTG
CACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGTCACTGCTGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTAT
TGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAGCTGGTTTATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAAC
CGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATGACAGAGGGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTG
AGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGAGGAAACGTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGAT
CACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGTTTTCAAAGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAAC
TAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTGATGCTCAATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCAT
TTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAGTAGAGTCCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATG
CTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTAGTATGGAAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACC
CACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTAAGTTTTTAGTGGGCATGAAAGGCAAGGATGAAGCTATGGCCATTG
GAGGCCACTGGTCTCCTTCGTTGGATGGACCAGACCCAGAAAAAGATCCCTCTGTGTTGATTAAGACTGCTATTCGTTGTTGTAAGGCTC
TGACAGGCATTGATCTAAGTGTGTGCACACAATGGTACCGTTTTGCAGAGATTCGCTACCATCGCCCTGAGGAGACCCACAAGGGGCGTA
CAGTTCCAGCTCATGTGGAGACAGTGGTTTTATTTTTCCCGGATGTTTGGCATTGCCTTCCCACCCGCTCAGAGTGGGAAACCCTCTCCC
GAGGATACAAGCAGCAGCTGGTCGAGAAGCTTCAGGGTGAACGCAAGGAGGCTGATGGAGAACAGGATGAAGAAGAGAAGGATGATGGTG
AAGCTAAAGAAATTTCTACACCTACCCATTGGTCTAAACTTGATCCAAAGACAATGAAGGTAAATGACCTCCGAAAAGAATTAGAAAGTC
GAGCTCTTAGTTCCAAAGGATTAAAATCCCAGTTAATAGCCCGATTGACAAAACAGCTTAAAGTAGAGGAACAAAAAGAAGAACAGAAGG
AGTTAGAGAAATCTGAAAAAGAAGAGGATGAGGATGATGATAGGAAATCTGAAGACGATAAAGAGGAAGAAGAAAGGAAACGTCAAGAGG
AAATAGAACGCCAGCGTCGAGAAAGAAGATATATTTTGCCTGATGAACCGGCCATCATTGTACATCCAAATTGGGCTGCAAAAAGTGGCA
AGTTTGATTGTAGCATCATGTCTTTGAGTGTCCTATTGGACTACAGATTAGAGGATAATAAAGAACATTCATTTGAGGTTTCATTGTTTG
CGGAACTTTTCAACGAAATGCTTCAAAGAGATTTTGGTGTCCGTATATACAAATCATTACTGTCTCTTCCTGAGAAAGAGGACAAAAAAG
AAAAGGATAAAAAAAGCAAAAAAGATGAGAGAAAAGATAAAAAAGAAGAAAGAGATGATGAAACTGATGAACCAAAACCCAAACGGAGAA
AATCAGGCGATGATAAAGATAAAAAAGAAGATAGAGATGAAAGGAAGAAAGAAGATAAAAGAAAAGATGATTCTAAAGATGATGATGAAA
CTGAAGAAGATAACAATCAAGATGAATATGACCCTATGGAAGCAGAAGAAGCTGAGGATGAAGAAGATGGTGTCATGGAGAAACTCCAGC
TGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAG
CTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTG
TGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTT
GGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGAT
TGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGT
GTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTG
AGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATA
CTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAA
CTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTATGCATGGAAACATGGAGGAAC
AGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATT
AGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATT
AAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATATACATTTATTTACACTCTTG
ATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTT
TGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCT
GTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAG
TCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGA
TTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTC
GTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCA
GCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGT
AGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAA
GGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTT
TTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAA
CTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTTAATCACAACTACTTACTAAG
GAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGT
CCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTA
TGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAAT
ATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAAT
ATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCAT
AAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGGACCTCCGTTTCT

>13513_13513_2_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000265872_AMACR_chr5_34006004_ENST00000382072_length(amino acids)=999AA_BP=883
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQQYSQPQQA
LYSVQQQLQQPQQTLLTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTP
QVGDRVLVEATYNPNMPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQ
QPQQKAGLLQPPVRIVSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVP
RYTVQFSKFSLDCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVM
LMASPSMEDLYHKSCALAEDPQELRDGFQHPARLVKFLVGMKGKDEAMAIGGHWSPSLDGPDPEKDPSVLIKTAIRCCKALTGIDLSVCT
QWYRFAEIRYHRPEETHKGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGERKEADGEQDEEEKDDGEAKEISTPTH
WSKLDPKTMKVNDLRKELESRALSSKGLKSQLIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRRERR
YILPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKDKKSKKDE
RKDKKEERDDETDEPKPKRRKSGDDKDKKEDRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEEDGVMEKLQLGPEILQREN
PRLIYARLSGFGQSGSFCRLAGHDINYLALSGGRNSIFKFFSVENSEIESVGSTSRTEHVGWWSTFLYDLQDSRWGIHGCWSNRTPVLRA

--------------------------------------------------------------
>13513_13513_3_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000535016_AMACR_chr5_34006004_ENST00000335606_length(transcript)=6541nt_BP=2724nt
GAAGTTGGCGCATGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGATCGATGCTATAGAAGACAAA
CAAGGGAAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAG
TATCACAGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAG
CAGGCCTTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTAC
AACAGTTACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTGTTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAG
CACAAATAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGCAAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAA
AACTACATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTCAGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAG
TATTGGTTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGAATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAA
CCCAGCCATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTGCACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGT
CACTGCTGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTATTGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAG
CTGGTTTATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAACCGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATG
ACAGAGGGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTGAGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGA
GGAAACGTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGATCACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGT
TTTCAAAGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAACTAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTG
ATGCTCAATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCATTTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAG
TAGAGTCCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATGCTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTA
GTATGGAAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACCCACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTA
AGTTTTTAGTGGGCATGAAAGGCAAGGATGAAGCTATGGCCATTGGAGGCCACTGGTCTCCTTCGTTGGATGGACCAGACCCAGAAAAAG
ATCCCTCTGTGTTGATTAAGACTGCTATTCGTTGTTGTAAGGCTCTGACAGGCATTGATCTAAGTGTGTGCACACAATGGTACCGTTTTG
CAGAGATTCGCTACCATCGCCCTGAGGAGACCCACAAGGGGCGTACAGTTCCAGCTCATGTGGAGACAGTGGTTTTATTTTTCCCGGATG
TTTGGCATTGCCTTCCCACCCGCTCAGAGTGGGAAACCCTCTCCCGAGGATACAAGCAGCAGCTGGTCGAGAAGCTTCAGGGTGAACGCA
AGGAGGCTGATGGAGAACAGGATGAAGAAGAGAAGGATGATGGTGAAGCTAAAGAAATTTCTACACCTACCCATTGGTCTAAACTTGATC
CAAAGACAATGAAGGTAAATGACCTCCGAAAAGAATTAGAAAGTCGAGCTCTTAGTTCCAAAGGATTAAAATCCCAGTTAATAGCCCGAT
TGACAAAACAGCTTAAAGTAGAGGAACAAAAAGAAGAACAGAAGGAGTTAGAGAAATCTGAAAAAGAAGAGGATGAGGATGATGATAGGA
AATCTGAAGACGATAAAGAGGAAGAAGAAAGGAAACGTCAAGAGGAAATAGAACGCCAGCGTCGAGAAAGAAGATATATTTTGCCTGATG
AACCGGCCATCATTGTACATCCAAATTGGGCTGCAAAAAGTGGCAAGTTTGATTGTAGCATCATGTCTTTGAGTGTCCTATTGGACTACA
GATTAGAGGATAATAAAGAACATTCATTTGAGGTTTCATTGTTTGCGGAACTTTTCAACGAAATGCTTCAAAGAGATTTTGGTGTCCGTA
TATACAAATCATTACTGTCTCTTCCTGAGAAAGAGGACAAAAAAGAAAAGGATAAAAAAAGCAAAAAAGATGAGAGAAAAGATAAAAAAG
AAGAAAGAGATGATGAAACTGATGAACCAAAACCCAAACGGAGAAAATCAGGCGATGATAAAGATAAAAAAGAAGATAGAGATGAAAGGA
AGAAAGAAGATAAAAGAAAAGATGATTCTAAAGATGATGATGAAACTGAAGAAGATAACAATCAAGATGAATATGACCCTATGGAAGCAG
AAGAAGCTGAGGATGAAGAAGATGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATG
CCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAA
AAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTA
TAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTC
TGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGA
CAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAAC
TTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTC
AAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGT
TTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTT
TCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAA
GTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACA
TTGTATGCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATG
ATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCA
GTTTGCTTGATATATTTGTTGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACA
TCGATATACATTTATTTACACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACA
GAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTT
GTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGC
TCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGT
CAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATA
AAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAA
GACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCA
CAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAA
CTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCA
TGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCA
ACGAATTAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTC
ATTGTTAATCACAACTACTTACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGC
CCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATT
ATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATT
GTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATA
CCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCT
TCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTG
GGGAACTTGGCTGGACCTCCGTTTCTACGAAATAAAAATAAAAAAATTATCCAGGTATGGTGGTGTGTGCCTGTAGTCCTATCTACTCAA
GGGTGGGGCAGGAGGATCACTTGAGCCCAGGAATTTGAGGCCACAGTGAATTAGGATTGCACCACTGCACTCTAGCCCAGGCAACAGAAC
AAGAACCTGTCTCTAAATAAATAAATAAAAATAATAATAATAAAAAAGATGTTTTCCCTACAACTCAGACTTTTCATTTGAACTCGGTCC
AGCAAGGAAAATATAACCCACTCGAAGTCTTTAAAACAGAGGAAATTTAATATAAAGAATTCCACTGGTGACGAAAGAGCAGAGAAGCCC
AGAAGATAGTGAGGCAACCCTGATAGGAACATAACTAGGAAGCCAAGACCACTCCTATGGTTGCAGGGGTGATGGGAAAGCTGGTGTACT
TGGACCCAGAAGCCAAAGTTGCTGCACCCACCTTGGAGACATAGACACTGGCAGTAATACCTCAGGGAGAAGAAAGAAATCTAGGGAAAT
ATCCTGGCTTCTTTCCTTCTCTCTCTCCCCTAGTCTTCCTACCAGTGTCTCCCATTAGCCAAATCTACCTAGAAGCCAGAAAACAAGGGA
ACCCTGGAAATGTAGCCCCATAAGATAAAGAGCACCAAAGGAAATAGATCTGAGCAGACAGGCAGCACAAAATGCAGTGTGTATGGTTTA
TTCACTCAGTAATTCCTTTAGCAAATGTTTATTGAGGATCTACTAGGTGCCAGGTATCATGATACTTGCTGGGGATACCATAATGAACAA
AACAGACCTGTTCTCCGCTCTTGAGGAAATCAAAGACAAACACAGGATATGGAATAAACCCAGAATTATCTCATTGTAAAATGTGTTAAG
TACCACGAGGAGAAATATCAGGGCGATCTGACACAGCTAATGATTTGAAGAAGGGTGTGACCTGCCACCATTTTAAATCTAGTTATTTCA

>13513_13513_3_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000535016_AMACR_chr5_34006004_ENST00000335606_length(amino acids)=1168AA_BP=868
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQLQQPQQTL
LTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTPQVGDRVLVEATYNPN
MPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRI
VSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPS
CDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVMLMASPSMEDLYHKSC
ALAEDPQELRDGFQHPARLVKFLVGMKGKDEAMAIGGHWSPSLDGPDPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRPEE
THKGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGERKEADGEQDEEEKDDGEAKEISTPTHWSKLDPKTMKVNDLR
KELESRALSSKGLKSQLIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRRERRYILPDEPAIIVHPNW
AAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKDKKSKKDERKDKKEERDDETDEP
KPKRRKSGDDKDKKEDRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEEDGVMEKLQLGPEILQRENPRLIYARLSGFGQSG
SFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLW
EAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACV

--------------------------------------------------------------
>13513_13513_4_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000535016_AMACR_chr5_34006004_ENST00000382072_length(transcript)=5384nt_BP=2724nt
GAAGTTGGCGCATGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGATCGATGCTATAGAAGACAAA
CAAGGGAAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAG
TATCACAGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAG
CAGGCCTTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTAC
AACAGTTACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTGTTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAG
CACAAATAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGCAAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAA
AACTACATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTCAGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAG
TATTGGTTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGAATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAA
CCCAGCCATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTGCACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGT
CACTGCTGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTATTGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAG
CTGGTTTATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAACCGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATG
ACAGAGGGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTGAGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGA
GGAAACGTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGATCACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGT
TTTCAAAGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAACTAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTG
ATGCTCAATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCATTTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAG
TAGAGTCCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATGCTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTA
GTATGGAAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACCCACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTA
AGTTTTTAGTGGGCATGAAAGGCAAGGATGAAGCTATGGCCATTGGAGGCCACTGGTCTCCTTCGTTGGATGGACCAGACCCAGAAAAAG
ATCCCTCTGTGTTGATTAAGACTGCTATTCGTTGTTGTAAGGCTCTGACAGGCATTGATCTAAGTGTGTGCACACAATGGTACCGTTTTG
CAGAGATTCGCTACCATCGCCCTGAGGAGACCCACAAGGGGCGTACAGTTCCAGCTCATGTGGAGACAGTGGTTTTATTTTTCCCGGATG
TTTGGCATTGCCTTCCCACCCGCTCAGAGTGGGAAACCCTCTCCCGAGGATACAAGCAGCAGCTGGTCGAGAAGCTTCAGGGTGAACGCA
AGGAGGCTGATGGAGAACAGGATGAAGAAGAGAAGGATGATGGTGAAGCTAAAGAAATTTCTACACCTACCCATTGGTCTAAACTTGATC
CAAAGACAATGAAGGTAAATGACCTCCGAAAAGAATTAGAAAGTCGAGCTCTTAGTTCCAAAGGATTAAAATCCCAGTTAATAGCCCGAT
TGACAAAACAGCTTAAAGTAGAGGAACAAAAAGAAGAACAGAAGGAGTTAGAGAAATCTGAAAAAGAAGAGGATGAGGATGATGATAGGA
AATCTGAAGACGATAAAGAGGAAGAAGAAAGGAAACGTCAAGAGGAAATAGAACGCCAGCGTCGAGAAAGAAGATATATTTTGCCTGATG
AACCGGCCATCATTGTACATCCAAATTGGGCTGCAAAAAGTGGCAAGTTTGATTGTAGCATCATGTCTTTGAGTGTCCTATTGGACTACA
GATTAGAGGATAATAAAGAACATTCATTTGAGGTTTCATTGTTTGCGGAACTTTTCAACGAAATGCTTCAAAGAGATTTTGGTGTCCGTA
TATACAAATCATTACTGTCTCTTCCTGAGAAAGAGGACAAAAAAGAAAAGGATAAAAAAAGCAAAAAAGATGAGAGAAAAGATAAAAAAG
AAGAAAGAGATGATGAAACTGATGAACCAAAACCCAAACGGAGAAAATCAGGCGATGATAAAGATAAAAAAGAAGATAGAGATGAAAGGA
AGAAAGAAGATAAAAGAAAAGATGATTCTAAAGATGATGATGAAACTGAAGAAGATAACAATCAAGATGAATATGACCCTATGGAAGCAG
AAGAAGCTGAGGATGAAGAAGATGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATG
CCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGGAAGGAACA
GCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCT
TTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTT
GGACTAAAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAG
ACGAAGGCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCAC
AACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCT
TCTTTCAAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAAC
TCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAG
TGTAGAGTAACACATAACATTGTATGCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGA
CTCTGATTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATG
GTAGTTATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAA
TGATATATTCTTGAAGACATCGATATACATTTATTTACACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTG
ATAAAAGTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTA
GCAACAGTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAAT
AATGAGGAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCC
CCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACAC
ACAGCAACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTAT
ACCTGTCTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGT
GAGGAAGGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCC
ATTCTGCGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTC
AGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTT
ATAAATAATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATA
TATTTTTCATTTCTATTTCATTGTTAATCACAACTACTTACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAA
TGAGATTGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGT
CTCACAAAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTG
ACAGATGTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCT
TGGCACAGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTC
TAGCCTTCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCA

>13513_13513_4_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000535016_AMACR_chr5_34006004_ENST00000382072_length(amino acids)=984AA_BP=868
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQLQQPQQTL
LTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTPQVGDRVLVEATYNPN
MPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRI
VSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPS
CDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVMLMASPSMEDLYHKSC
ALAEDPQELRDGFQHPARLVKFLVGMKGKDEAMAIGGHWSPSLDGPDPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRPEE
THKGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGERKEADGEQDEEEKDDGEAKEISTPTHWSKLDPKTMKVNDLR
KELESRALSSKGLKSQLIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRRERRYILPDEPAIIVHPNW
AAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKDKKSKKDERKDKKEERDDETDEP
KPKRRKSGDDKDKKEDRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEEDGVMEKLQLGPEILQRENPRLIYARLSGFGQSG

--------------------------------------------------------------
>13513_13513_5_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000543719_AMACR_chr5_34006004_ENST00000335606_length(transcript)=6535nt_BP=2718nt
TGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGGTGAAGATCGATGCTATAGAAGACAAACAAGGG
AAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAGTATCAC
AGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAGCAGGCC
TTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTACAACAGT
TACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTGTTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAGCACAAA
TAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGCAAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAAAACTAC
ATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTCAGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAGTATTGG
TTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGAATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAACCCAGC
CATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTGCACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGTCACTGC
TGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTATTGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAGCTGGTT
TATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAACCGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATGACAGAG
GGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTGAGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGAGGAAAC
GTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGATCACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGTTTTCAA
AGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAACTAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTGATGCTC
AATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCATTTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAGTAGAGT
CCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATGCTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTAGTATGG
AAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACCCACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTAAGTTTT
TAGTGGGCATGAAAGGCAAGGATGAAGCTATGGCCATTGGAGGCCACTGGTCTCCTTCGTTGGATGGACCAGACCCAGAAAAAGATCCCT
CTGTGTTGATTAAGACTGCTATTCGTTGTTGTAAGGCTCTGACAGGCATTGATCTAAGTGTGTGCACACAATGGTACCGTTTTGCAGAGA
TTCGCTACCATCGCCCTGAGGAGACCCACAAGGGGCGTACAGTTCCAGCTCATGTGGAGACAGTGGTTTTATTTTTCCCGGATGTTTGGC
ATTGCCTTCCCACCCGCTCAGAGTGGGAAACCCTCTCCCGAGGATACAAGCAGCAGCTGGTCGAGAAGCTTCAGGGTGAACGCAAGGAGG
CTGATGGAGAACAGGATGAAGAAGAGAAGGATGATGGTGAAGCTAAAGAAATTTCTACACCTACCCATTGGTCTAAACTTGATCCAAAGA
CAATGAAGGTAAATGACCTCCGAAAAGAATTAGAAAGTCGAGCTCTTAGTTCCAAAGGATTAAAATCCCAGTTAATAGCCCGATTGACAA
AACAGCTTAAAGTAGAGGAACAAAAAGAAGAACAGAAGGAGTTAGAGAAATCTGAAAAAGAAGAGGATGAGGATGATGATAGGAAATCTG
AAGACGATAAAGAGGAAGAAGAAAGGAAACGTCAAGAGGAAATAGAACGCCAGCGTCGAGAAAGAAGATATATTTTGCCTGATGAACCGG
CCATCATTGTACATCCAAATTGGGCTGCAAAAAGTGGCAAGTTTGATTGTAGCATCATGTCTTTGAGTGTCCTATTGGACTACAGATTAG
AGGATAATAAAGAACATTCATTTGAGGTTTCATTGTTTGCGGAACTTTTCAACGAAATGCTTCAAAGAGATTTTGGTGTCCGTATATACA
AATCATTACTGTCTCTTCCTGAGAAAGAGGACAAAAAAGAAAAGGATAAAAAAAGCAAAAAAGATGAGAGAAAAGATAAAAAAGAAGAAA
GAGATGATGAAACTGATGAACCAAAACCCAAACGGAGAAAATCAGGCGATGATAAAGATAAAAAAGAAGATAGAGATGAAAGGAAGAAAG
AAGATAAAAGAAAAGATGATTCTAAAGATGATGATGAAACTGAAGAAGATAACAATCAAGATGAATATGACCCTATGGAAGCAGAAGAAG
CTGAGGATGAAGAAGATGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGC
TGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTG
GCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGG
CTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGA
AAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAG
ATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCA
ATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCT
TTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCA
CCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAG
GAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATA
AGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTAT
GCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAA
TTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGC
TTGATATATTTGTTGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATA
TACATTTATTTACACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGA
TTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATT
TGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTA
CGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTT
TCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATC
TCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGG
ATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCT
AATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCG
TTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTC
CCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAAT
TAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTT
AATCACAACTACTTACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCAT
TTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGA
AGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTT
GTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTT
GAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACC
ATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAAC
TTGGCTGGACCTCCGTTTCTACGAAATAAAAATAAAAAAATTATCCAGGTATGGTGGTGTGTGCCTGTAGTCCTATCTACTCAAGGGTGG
GGCAGGAGGATCACTTGAGCCCAGGAATTTGAGGCCACAGTGAATTAGGATTGCACCACTGCACTCTAGCCCAGGCAACAGAACAAGAAC
CTGTCTCTAAATAAATAAATAAAAATAATAATAATAAAAAAGATGTTTTCCCTACAACTCAGACTTTTCATTTGAACTCGGTCCAGCAAG
GAAAATATAACCCACTCGAAGTCTTTAAAACAGAGGAAATTTAATATAAAGAATTCCACTGGTGACGAAAGAGCAGAGAAGCCCAGAAGA
TAGTGAGGCAACCCTGATAGGAACATAACTAGGAAGCCAAGACCACTCCTATGGTTGCAGGGGTGATGGGAAAGCTGGTGTACTTGGACC
CAGAAGCCAAAGTTGCTGCACCCACCTTGGAGACATAGACACTGGCAGTAATACCTCAGGGAGAAGAAAGAAATCTAGGGAAATATCCTG
GCTTCTTTCCTTCTCTCTCTCCCCTAGTCTTCCTACCAGTGTCTCCCATTAGCCAAATCTACCTAGAAGCCAGAAAACAAGGGAACCCTG
GAAATGTAGCCCCATAAGATAAAGAGCACCAAAGGAAATAGATCTGAGCAGACAGGCAGCACAAAATGCAGTGTGTATGGTTTATTCACT
CAGTAATTCCTTTAGCAAATGTTTATTGAGGATCTACTAGGTGCCAGGTATCATGATACTTGCTGGGGATACCATAATGAACAAAACAGA
CCTGTTCTCCGCTCTTGAGGAAATCAAAGACAAACACAGGATATGGAATAAACCCAGAATTATCTCATTGTAAAATGTGTTAAGTACCAC
GAGGAGAAATATCAGGGCGATCTGACACAGCTAATGATTTGAAGAAGGGTGTGACCTGCCACCATTTTAAATCTAGTTATTTCACTCCTG

>13513_13513_5_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000543719_AMACR_chr5_34006004_ENST00000335606_length(amino acids)=1168AA_BP=868
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQLQQPQQTL
LTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTPQVGDRVLVEATYNPN
MPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRI
VSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPS
CDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVMLMASPSMEDLYHKSC
ALAEDPQELRDGFQHPARLVKFLVGMKGKDEAMAIGGHWSPSLDGPDPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRPEE
THKGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGERKEADGEQDEEEKDDGEAKEISTPTHWSKLDPKTMKVNDLR
KELESRALSSKGLKSQLIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRRERRYILPDEPAIIVHPNW
AAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKDKKSKKDERKDKKEERDDETDEP
KPKRRKSGDDKDKKEDRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEEDGVMEKLQLGPEILQRENPRLIYARLSGFGQSG
SFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLW
EAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACV

--------------------------------------------------------------
>13513_13513_6_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000543719_AMACR_chr5_34006004_ENST00000382072_length(transcript)=5378nt_BP=2718nt
TGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGGTGAAGATCGATGCTATAGAAGACAAACAAGGG
AAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAGTATCAC
AGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAGCAGGCC
TTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTACAACAGT
TACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTGTTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAGCACAAA
TAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGCAAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAAAACTAC
ATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTCAGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAGTATTGG
TTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGAATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAACCCAGC
CATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTGCACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGTCACTGC
TGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTATTGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAGCTGGTT
TATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAACCGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATGACAGAG
GGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTGAGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGAGGAAAC
GTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGATCACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGTTTTCAA
AGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAACTAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTGATGCTC
AATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCATTTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAGTAGAGT
CCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATGCTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTAGTATGG
AAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACCCACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTAAGTTTT
TAGTGGGCATGAAAGGCAAGGATGAAGCTATGGCCATTGGAGGCCACTGGTCTCCTTCGTTGGATGGACCAGACCCAGAAAAAGATCCCT
CTGTGTTGATTAAGACTGCTATTCGTTGTTGTAAGGCTCTGACAGGCATTGATCTAAGTGTGTGCACACAATGGTACCGTTTTGCAGAGA
TTCGCTACCATCGCCCTGAGGAGACCCACAAGGGGCGTACAGTTCCAGCTCATGTGGAGACAGTGGTTTTATTTTTCCCGGATGTTTGGC
ATTGCCTTCCCACCCGCTCAGAGTGGGAAACCCTCTCCCGAGGATACAAGCAGCAGCTGGTCGAGAAGCTTCAGGGTGAACGCAAGGAGG
CTGATGGAGAACAGGATGAAGAAGAGAAGGATGATGGTGAAGCTAAAGAAATTTCTACACCTACCCATTGGTCTAAACTTGATCCAAAGA
CAATGAAGGTAAATGACCTCCGAAAAGAATTAGAAAGTCGAGCTCTTAGTTCCAAAGGATTAAAATCCCAGTTAATAGCCCGATTGACAA
AACAGCTTAAAGTAGAGGAACAAAAAGAAGAACAGAAGGAGTTAGAGAAATCTGAAAAAGAAGAGGATGAGGATGATGATAGGAAATCTG
AAGACGATAAAGAGGAAGAAGAAAGGAAACGTCAAGAGGAAATAGAACGCCAGCGTCGAGAAAGAAGATATATTTTGCCTGATGAACCGG
CCATCATTGTACATCCAAATTGGGCTGCAAAAAGTGGCAAGTTTGATTGTAGCATCATGTCTTTGAGTGTCCTATTGGACTACAGATTAG
AGGATAATAAAGAACATTCATTTGAGGTTTCATTGTTTGCGGAACTTTTCAACGAAATGCTTCAAAGAGATTTTGGTGTCCGTATATACA
AATCATTACTGTCTCTTCCTGAGAAAGAGGACAAAAAAGAAAAGGATAAAAAAAGCAAAAAAGATGAGAGAAAAGATAAAAAAGAAGAAA
GAGATGATGAAACTGATGAACCAAAACCCAAACGGAGAAAATCAGGCGATGATAAAGATAAAAAAGAAGATAGAGATGAAAGGAAGAAAG
AAGATAAAAGAAAAGATGATTCTAAAGATGATGATGAAACTGAAGAAGATAACAATCAAGATGAATATGACCCTATGGAAGCAGAAGAAG
CTGAGGATGAAGAAGATGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGC
TGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGGAAGGAACAGCATAT
TTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTAT
ACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTA
AAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAG
GCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAG
GAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTC
AAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGAT
AAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGA
GTAACACATAACATTGTATGCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGA
TTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTT
ATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATAT
ATTCTTGAAGACATCGATATACATTTATTTACACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAA
GTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACA
GTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAG
GAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGG
GTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCA
ACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGT
CTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAA
GGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTG
CGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGG
GCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAAT
AATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTT
TCATTTCTATTTCATTGTTAATCACAACTACTTACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGAT
TGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACA
AAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGAT
GTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCAC
AGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCT
TCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTT

>13513_13513_6_CCAR1-AMACR_CCAR1_chr10_70532856_ENST00000543719_AMACR_chr5_34006004_ENST00000382072_length(amino acids)=984AA_BP=868
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQLQQPQQTL
LTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTPQVGDRVLVEATYNPN
MPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRI
VSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPS
CDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVMLMASPSMEDLYHKSC
ALAEDPQELRDGFQHPARLVKFLVGMKGKDEAMAIGGHWSPSLDGPDPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRPEE
THKGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGERKEADGEQDEEEKDDGEAKEISTPTHWSKLDPKTMKVNDLR
KELESRALSSKGLKSQLIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRRERRYILPDEPAIIVHPNW
AAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKDKKSKKDERKDKKEERDDETDEP
KPKRRKSGDDKDKKEDRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEEDGVMEKLQLGPEILQRENPRLIYARLSGFGQSG

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Fusion Gene PPI Analysis for CCAR1-AMACR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCCAR1chr10:70532856chr5:34006004ENST00000265872+19251_249883.33333333333341151.0AR
HgeneCCAR1chr10:70532856chr5:34006004ENST00000535016+18241_249868.33333333333341136.0AR
HgeneCCAR1chr10:70532856chr5:34006004ENST00000543719+18241_249868.33333333333341136.0AR
HgeneCCAR1chr10:70532856chr5:34006004ENST00000265872+1925203_660883.33333333333341151.0GATA2
HgeneCCAR1chr10:70532856chr5:34006004ENST00000535016+1824203_660868.33333333333341136.0GATA2
HgeneCCAR1chr10:70532856chr5:34006004ENST00000543719+1824203_660868.33333333333341136.0GATA2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCCAR1chr10:70532856chr5:34006004ENST00000265872+1925643_1150883.33333333333341151.0GATA1
HgeneCCAR1chr10:70532856chr5:34006004ENST00000535016+1824643_1150868.33333333333341136.0GATA1
HgeneCCAR1chr10:70532856chr5:34006004ENST00000543719+1824643_1150868.33333333333341136.0GATA1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCAR1-AMACR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCAR1-AMACR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource