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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CCAR1-CAAP1 (FusionGDB2 ID:13515)

Fusion Gene Summary for CCAR1-CAAP1

Fusion gene summary

Fusion gene information	Fusion gene name: CCAR1-CAAP1
	Fusion gene ID: 13515
		Hgene	Tgene
	Gene symbol	CCAR1	CAAP1
	Gene ID	55749	79886
	Gene name	cell division cycle and apoptosis regulator 1	caspase activity and apoptosis inhibitor 1
	Synonyms	-	C9orf82\|CAAP
	Cytomap	10q21.3	9p21.2
	Type of gene	protein-coding	protein-coding
	Description	cell division cycle and apoptosis regulator protein 1cell cycle and apoptosis regulatory protein 1death inducer with SAP domain	caspase activity and apoptosis inhibitor 1conserved anti-apoptotic protein
	Modification date	20200313	20200313
	UniProtAcc	Q8IX12	Q9H8G2
	Ensembl transtripts involved in fusion gene	ENST00000265872, ENST00000535016, ENST00000543719, ENST00000483264,	ENST00000495958, ENST00000535437, ENST00000520187, ENST00000333916,
Fusion gene scores	* DoF score	13 X 11 X 8=1144	3 X 2 X 3=18
	# samples	17	4
	** MAII score	log2(17/1144*10)=-2.75048040064069 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CCAR1 [Title/Abstract] AND CAAP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CCAR1(70514584)-CAAP1(26887511), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CCAR1	GO:0043065	positive regulation of apoptotic process	12816952

Fusion gene breakpoints across CCAR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CAAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-N8-A4PL	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-

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Fusion Gene ORF analysis for CCAR1-CAAP1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000265872	ENST00000495958	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
5CDS-5UTR	ENST00000265872	ENST00000535437	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
5CDS-5UTR	ENST00000535016	ENST00000495958	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
5CDS-5UTR	ENST00000535016	ENST00000535437	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
5CDS-5UTR	ENST00000543719	ENST00000495958	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
5CDS-5UTR	ENST00000543719	ENST00000535437	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
5CDS-intron	ENST00000265872	ENST00000520187	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
5CDS-intron	ENST00000535016	ENST00000520187	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
5CDS-intron	ENST00000543719	ENST00000520187	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
In-frame	ENST00000265872	ENST00000333916	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
In-frame	ENST00000535016	ENST00000333916	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
In-frame	ENST00000543719	ENST00000333916	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
intron-3CDS	ENST00000483264	ENST00000333916	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
intron-5UTR	ENST00000483264	ENST00000495958	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
intron-5UTR	ENST00000483264	ENST00000535437	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-
intron-intron	ENST00000483264	ENST00000520187	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000535016	CCAR1	chr10	70514584	+	ENST00000333916	CAAP1	chr9	26887511	-	3931	1532	119	2314	731
ENST00000265872	CCAR1	chr10	70514584	+	ENST00000333916	CAAP1	chr9	26887511	-	3976	1577	119	2359	746
ENST00000543719	CCAR1	chr10	70514584	+	ENST00000333916	CAAP1	chr9	26887511	-	3925	1526	113	2308	731

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000535016	ENST00000333916	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-	0.000848914	0.9991511
ENST00000265872	ENST00000333916	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-	0.001050107	0.99894994
ENST00000543719	ENST00000333916	CCAR1	chr10	70514584	+	CAAP1	chr9	26887511	-	0.000830184	0.9991698

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Fusion Genomic Features for CCAR1-CAAP1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCAR1-CAAP1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:70514584/chr9:26887511)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CCAR1 Q8IX12	CAAP1 Q9H8G2
FUNCTION: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250\|UniProtKB:Q8CH18, ECO:0000269\|PubMed:12816952, ECO:0000269\|PubMed:23887938, ECO:0000269\|PubMed:24245781}.	FUNCTION: Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269\|PubMed:21980415}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000265872

293_361

486

1151.0

Compositional bias

Note=Arg-rich

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000265872

73_79

486

1151.0

Compositional bias

Note=Poly-Ala

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000535016

293_361

471

1136.0

Compositional bias

Note=Arg-rich

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000535016

73_79

471

1136.0

Compositional bias

Note=Poly-Ala

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000543719

293_361

471

1136.0

Compositional bias

Note=Arg-rich

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000543719

73_79

471

1136.0

Compositional bias

Note=Poly-Ala

Tgene

CAAP1

chr10:70514584

chr9:26887511

ENST00000333916

281_311

101

362.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CAAP1

chr10:70514584

chr9:26887511

ENST00000535437

281_311

217.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CAAP1

chr10:70514584

chr9:26887511

ENST00000535437

19_25

217.0

Compositional bias

Note=Poly-Ala

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000265872

1033_1114

486

1151.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000265872

594_618

486

1151.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000535016

1033_1114

471

1136.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000535016

594_618

471

1136.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000543719

1033_1114

471

1136.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000543719

594_618

471

1136.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000265872

673_889

486

1151.0

Compositional bias

Note=Glu-rich

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000535016

673_889

471

1136.0

Compositional bias

Note=Glu-rich

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000543719

673_889

471

1136.0

Compositional bias

Note=Glu-rich

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000265872

636_670

486

1151.0

Domain

SAP

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000535016

636_670

471

1136.0

Domain

SAP

Hgene

CCAR1

chr10:70514584

chr9:26887511

ENST00000543719

636_670

471

1136.0

Domain

SAP

Tgene

CAAP1

chr10:70514584

chr9:26887511

ENST00000333916

19_25

101

362.0

Compositional bias

Note=Poly-Ala

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Fusion Gene Sequence for CCAR1-CAAP1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>13515_13515_1_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000265872_CAAP1_chr9_26887511_ENST00000333916_length(transcript)=3976nt_BP=1577nt
GAAGTTGGCGCATGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGATCGATGCTATAGAAGACAAA
CAAGGGAAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAG
TATCACAGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAG
CAGGCCTTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTAC
AACAGCAATATTCACAACCTCAGCAGGCCCTGTATAGTGTGCAACAACAGTTACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTG
TTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAGCACAAATAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGC
AAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAAAACTACATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTC
AGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAGTATTGGTTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGA
ATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAACCCAGCCATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTG
CACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGTCACTGCTGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTAT
TGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAGCTGGTTTATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAAC
CGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATGACAGAGGGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTG
AGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGAGGAAACGTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGAT
CACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGTTTTCAAAGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAAC
TAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTGATGCTCAATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCAT
TTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAGTAGAGTCCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATG
CTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTAGTATGGAAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACC
CACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTAAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCT
TGGCAGAGCACAGTGACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAA
TGCTTCAGCAGTGCTTCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTA
AAAAACTATGCCAGGAACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGG
AAGAGGAAGCAGATGATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGCAAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGA
ATAAGCAACCTGAAGGTTTGGAATTAAAACAAGGAAAAGGGGAAGATAGTGATGTACTCAGTATAAATGCAGATGCTTATGACAGCGACA
TAGAAGGCCCATGCAACGAAGAAGCAGCTGCTCCCGAGGCACCAGAAAATACAGTCCAAAGTGAAGCTGGTCAGATAGATGACCTGGAGA
AAGACATTGAGAAAAGTGTGAATGAGATTCTAGGACTGGCAGAGTCTAGCCCAAACGAACCCAAAGCAGCCACCCTGGCTGTTCCTCCAC
CAGAAGATGTTCAACCTTCTGCACAGCAACTGGAGCTGCTAGAACTTGAGATGAGGGCAAGAGCGATTAAAGCCCTAATGAAAGCTGGTG
ATATAAAAAAGCCAGCCTAGGTATTTAACTTGATTTTGAATTTTAGGTATGTTTGAACAAAGCCACATCATTTAATTTTGTATCTAAAAT
TTATTTGGGGTCTTATATGTTATTTCTCATGTAACCCTTATTAGGACTCATTTTAGCCCTAAATTACCTGTGGCTGTTTCTTTTTATTTT
TTTGACTACTTTTATATTATAAATGTGTGTTACTGTCTTATGAATTCATGGCAATATAGTTGGATAGCCTGGATACTTTGTTAGATGAGT
ATTTAGCTGTGTCTGCAAATCTTAAAAGCCATTAGCAAAGAGTCGTGGTATTTTTTTCTTTATTTTTAAATGTTTGGGCACCAAACCTAA
AAGCAAAAGATTGACGAAGCATGTTTCTCTTAAGGCTACTTGTATTTTACAATACAATATTAAATTATTTAATTTGAGAAATTTAGTTTT
GCTTATATGCACTTTTTAAATATATACTATTTTGAAGATTCCTTATGTAAATGCAAATTTCCTAGTTAAAACCGAATAACAGAGATCTGA
AATGACTGAGAAAAACTTTTTTATTAAAGGAAGGAATTAATTTAAGGCAATTTTTAACTATGTAGAACTAATTGCCCATGTTTAATTATA
GCAGACACGCCATTCTAACAGGTATTTGATACCATTGGATGCATTATTCTAGGTTTTTTCTTTAATAAAAATGGAACAAGTTTTCATTTA
CATTCCAAGCTGTCAGGAAATGAAGAATATTTTATTATCTAGGATTTTATCTGATGTAGTTGCTTAAAGATCTGATGTGCTATAATTCCA
TGAATCAGAAATAATAAAATGCTATCATTCTGGATCTGAAGACTTTTGATACTTTTTCAAAAGCAAAATTAATTTCAGGAACCTTTGATA
AGTTGTTGTTATAATTAATCTAATTTTGTATAGTTTTTGTAAATAAATTACCATCCTTCCACAATTAGGGATGCTTTTATCCCCCCATCA
CTAATTGCAGTTGTTTGATACCAAAATAAATTTACGTAGAGATCCTTAACTTAAAATAAATTAATTTTTTCAAAAAACATAAATCTGGAA
CTGTTGTTTCTATATTTGATAACAAATACAGTATATTTTATTTATAAGCCATGGTCTACTGATACTGTATGAGGACTTTCCTTATATATA
AAAGTTGCAGGGATTGTGTTTTATTAGCTGCTTTAATTATGTTAATTTTAGAGAGTTTTTAAATGGAAATAGAGGACATTTATGAAACGC
TGGAATTGCAGTTACAAATTCTTTTTGTTGTTGTTGTTCCTGAACATGCCTTGGAATAATTCTACCATTTTTTCCCCCTCCATAAATCTT
TCTAATAAAGCATAGAAAAAGCCTATATGATTTTAAATGCTTCTCTTAAGCTGGTAAACAGATTTGAGTTATGAGTTCATTGTTATTGCT
TCAAGATGAAAAGACAGTGATATAATTTTTCTATTTCAACTTAAAAGTAATAGTTAATATGCTAAAGTAGTACAGAATAAACTTTATTGC
TGCTTACTAACTACAAAATACTGTAGATGGCATCTGTATGATTAAACATATAAAGTAAAACAGGTCTGAGGGCTTTGTAGATGATTAAAG

>13515_13515_1_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000265872_CAAP1_chr9_26887511_ENST00000333916_length(amino acids)=746AA_BP=486
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQQYSQPQQA
LYSVQQQLQQPQQTLLTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTP
QVGDRVLVEATYNPNMPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQ
QPQQKAGLLQPPVRIVSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVP
RYTVQFSKFSLDCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVM
LMASPSMEDLYHKSCALAEDPQELRDGFQHPARLVKETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIG
EKKLQKMLPDVLKNCSIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELK
QGKGEDSDVLSINADAYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQ

--------------------------------------------------------------
>13515_13515_2_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000535016_CAAP1_chr9_26887511_ENST00000333916_length(transcript)=3931nt_BP=1532nt
GAAGTTGGCGCATGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGATCGATGCTATAGAAGACAAA
CAAGGGAAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAG
TATCACAGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAG
CAGGCCTTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTAC
AACAGTTACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTGTTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAG
CACAAATAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGCAAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAA
AACTACATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTCAGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAG
TATTGGTTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGAATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAA
CCCAGCCATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTGCACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGT
CACTGCTGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTATTGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAG
CTGGTTTATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAACCGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATG
ACAGAGGGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTGAGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGA
GGAAACGTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGATCACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGT
TTTCAAAGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAACTAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTG
ATGCTCAATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCATTTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAG
TAGAGTCCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATGCTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTA
GTATGGAAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACCCACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTA
AGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTGACCTTGAAGAAGGTGGACTGGACCTGACTG
TGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCTTCTGTATTATAGGAGAGAAAAAGTTACAGA
AGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGGAACAGTTAGAGCTCCTGTCTGAAAAAAAAA
TTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATGATGGTTCTAAGATGGGATCTGATTTAGTCA
GTCAGCAAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGAATAAGCAACCTGAAGGTTTGGAATTAAAACAAGGAAAAGGGGAAG
ATAGTGATGTACTCAGTATAAATGCAGATGCTTATGACAGCGACATAGAAGGCCCATGCAACGAAGAAGCAGCTGCTCCCGAGGCACCAG
AAAATACAGTCCAAAGTGAAGCTGGTCAGATAGATGACCTGGAGAAAGACATTGAGAAAAGTGTGAATGAGATTCTAGGACTGGCAGAGT
CTAGCCCAAACGAACCCAAAGCAGCCACCCTGGCTGTTCCTCCACCAGAAGATGTTCAACCTTCTGCACAGCAACTGGAGCTGCTAGAAC
TTGAGATGAGGGCAAGAGCGATTAAAGCCCTAATGAAAGCTGGTGATATAAAAAAGCCAGCCTAGGTATTTAACTTGATTTTGAATTTTA
GGTATGTTTGAACAAAGCCACATCATTTAATTTTGTATCTAAAATTTATTTGGGGTCTTATATGTTATTTCTCATGTAACCCTTATTAGG
ACTCATTTTAGCCCTAAATTACCTGTGGCTGTTTCTTTTTATTTTTTTGACTACTTTTATATTATAAATGTGTGTTACTGTCTTATGAAT
TCATGGCAATATAGTTGGATAGCCTGGATACTTTGTTAGATGAGTATTTAGCTGTGTCTGCAAATCTTAAAAGCCATTAGCAAAGAGTCG
TGGTATTTTTTTCTTTATTTTTAAATGTTTGGGCACCAAACCTAAAAGCAAAAGATTGACGAAGCATGTTTCTCTTAAGGCTACTTGTAT
TTTACAATACAATATTAAATTATTTAATTTGAGAAATTTAGTTTTGCTTATATGCACTTTTTAAATATATACTATTTTGAAGATTCCTTA
TGTAAATGCAAATTTCCTAGTTAAAACCGAATAACAGAGATCTGAAATGACTGAGAAAAACTTTTTTATTAAAGGAAGGAATTAATTTAA
GGCAATTTTTAACTATGTAGAACTAATTGCCCATGTTTAATTATAGCAGACACGCCATTCTAACAGGTATTTGATACCATTGGATGCATT
ATTCTAGGTTTTTTCTTTAATAAAAATGGAACAAGTTTTCATTTACATTCCAAGCTGTCAGGAAATGAAGAATATTTTATTATCTAGGAT
TTTATCTGATGTAGTTGCTTAAAGATCTGATGTGCTATAATTCCATGAATCAGAAATAATAAAATGCTATCATTCTGGATCTGAAGACTT
TTGATACTTTTTCAAAAGCAAAATTAATTTCAGGAACCTTTGATAAGTTGTTGTTATAATTAATCTAATTTTGTATAGTTTTTGTAAATA
AATTACCATCCTTCCACAATTAGGGATGCTTTTATCCCCCCATCACTAATTGCAGTTGTTTGATACCAAAATAAATTTACGTAGAGATCC
TTAACTTAAAATAAATTAATTTTTTCAAAAAACATAAATCTGGAACTGTTGTTTCTATATTTGATAACAAATACAGTATATTTTATTTAT
AAGCCATGGTCTACTGATACTGTATGAGGACTTTCCTTATATATAAAAGTTGCAGGGATTGTGTTTTATTAGCTGCTTTAATTATGTTAA
TTTTAGAGAGTTTTTAAATGGAAATAGAGGACATTTATGAAACGCTGGAATTGCAGTTACAAATTCTTTTTGTTGTTGTTGTTCCTGAAC
ATGCCTTGGAATAATTCTACCATTTTTTCCCCCTCCATAAATCTTTCTAATAAAGCATAGAAAAAGCCTATATGATTTTAAATGCTTCTC
TTAAGCTGGTAAACAGATTTGAGTTATGAGTTCATTGTTATTGCTTCAAGATGAAAAGACAGTGATATAATTTTTCTATTTCAACTTAAA
AGTAATAGTTAATATGCTAAAGTAGTACAGAATAAACTTTATTGCTGCTTACTAACTACAAAATACTGTAGATGGCATCTGTATGATTAA

>13515_13515_2_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000535016_CAAP1_chr9_26887511_ENST00000333916_length(amino acids)=731AA_BP=471
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQLQQPQQTL
LTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTPQVGDRVLVEATYNPN
MPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRI
VSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPS
CDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVMLMASPSMEDLYHKSC
ALAEDPQELRDGFQHPARLVKETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNC
SIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGKGEDSDVLSINAD
AYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQLELLELEMRARAIKA

--------------------------------------------------------------
>13515_13515_3_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000543719_CAAP1_chr9_26887511_ENST00000333916_length(transcript)=3925nt_BP=1526nt
TGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGGTGAAGATCGATGCTATAGAAGACAAACAAGGG
AAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAGTATCAC
AGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAGCAGGCC
TTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTACAACAGT
TACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTGTTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAGCACAAA
TAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGCAAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAAAACTAC
ATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTCAGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAGTATTGG
TTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGAATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAACCCAGC
CATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTGCACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGTCACTGC
TGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTATTGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAGCTGGTT
TATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAACCGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATGACAGAG
GGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTGAGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGAGGAAAC
GTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGATCACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGTTTTCAA
AGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAACTAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTGATGCTC
AATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCATTTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAGTAGAGT
CCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATGCTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTAGTATGG
AAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACCCACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTAAGGAAA
CTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTGACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCAT
TGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCTTCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGC
TTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGGAACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGA
AGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATGATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGC
AAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGAATAAGCAACCTGAAGGTTTGGAATTAAAACAAGGAAAAGGGGAAGATAGTG
ATGTACTCAGTATAAATGCAGATGCTTATGACAGCGACATAGAAGGCCCATGCAACGAAGAAGCAGCTGCTCCCGAGGCACCAGAAAATA
CAGTCCAAAGTGAAGCTGGTCAGATAGATGACCTGGAGAAAGACATTGAGAAAAGTGTGAATGAGATTCTAGGACTGGCAGAGTCTAGCC
CAAACGAACCCAAAGCAGCCACCCTGGCTGTTCCTCCACCAGAAGATGTTCAACCTTCTGCACAGCAACTGGAGCTGCTAGAACTTGAGA
TGAGGGCAAGAGCGATTAAAGCCCTAATGAAAGCTGGTGATATAAAAAAGCCAGCCTAGGTATTTAACTTGATTTTGAATTTTAGGTATG
TTTGAACAAAGCCACATCATTTAATTTTGTATCTAAAATTTATTTGGGGTCTTATATGTTATTTCTCATGTAACCCTTATTAGGACTCAT
TTTAGCCCTAAATTACCTGTGGCTGTTTCTTTTTATTTTTTTGACTACTTTTATATTATAAATGTGTGTTACTGTCTTATGAATTCATGG
CAATATAGTTGGATAGCCTGGATACTTTGTTAGATGAGTATTTAGCTGTGTCTGCAAATCTTAAAAGCCATTAGCAAAGAGTCGTGGTAT
TTTTTTCTTTATTTTTAAATGTTTGGGCACCAAACCTAAAAGCAAAAGATTGACGAAGCATGTTTCTCTTAAGGCTACTTGTATTTTACA
ATACAATATTAAATTATTTAATTTGAGAAATTTAGTTTTGCTTATATGCACTTTTTAAATATATACTATTTTGAAGATTCCTTATGTAAA
TGCAAATTTCCTAGTTAAAACCGAATAACAGAGATCTGAAATGACTGAGAAAAACTTTTTTATTAAAGGAAGGAATTAATTTAAGGCAAT
TTTTAACTATGTAGAACTAATTGCCCATGTTTAATTATAGCAGACACGCCATTCTAACAGGTATTTGATACCATTGGATGCATTATTCTA
GGTTTTTTCTTTAATAAAAATGGAACAAGTTTTCATTTACATTCCAAGCTGTCAGGAAATGAAGAATATTTTATTATCTAGGATTTTATC
TGATGTAGTTGCTTAAAGATCTGATGTGCTATAATTCCATGAATCAGAAATAATAAAATGCTATCATTCTGGATCTGAAGACTTTTGATA
CTTTTTCAAAAGCAAAATTAATTTCAGGAACCTTTGATAAGTTGTTGTTATAATTAATCTAATTTTGTATAGTTTTTGTAAATAAATTAC
CATCCTTCCACAATTAGGGATGCTTTTATCCCCCCATCACTAATTGCAGTTGTTTGATACCAAAATAAATTTACGTAGAGATCCTTAACT
TAAAATAAATTAATTTTTTCAAAAAACATAAATCTGGAACTGTTGTTTCTATATTTGATAACAAATACAGTATATTTTATTTATAAGCCA
TGGTCTACTGATACTGTATGAGGACTTTCCTTATATATAAAAGTTGCAGGGATTGTGTTTTATTAGCTGCTTTAATTATGTTAATTTTAG
AGAGTTTTTAAATGGAAATAGAGGACATTTATGAAACGCTGGAATTGCAGTTACAAATTCTTTTTGTTGTTGTTGTTCCTGAACATGCCT
TGGAATAATTCTACCATTTTTTCCCCCTCCATAAATCTTTCTAATAAAGCATAGAAAAAGCCTATATGATTTTAAATGCTTCTCTTAAGC
TGGTAAACAGATTTGAGTTATGAGTTCATTGTTATTGCTTCAAGATGAAAAGACAGTGATATAATTTTTCTATTTCAACTTAAAAGTAAT
AGTTAATATGCTAAAGTAGTACAGAATAAACTTTATTGCTGCTTACTAACTACAAAATACTGTAGATGGCATCTGTATGATTAAACATAT

>13515_13515_3_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000543719_CAAP1_chr9_26887511_ENST00000333916_length(amino acids)=731AA_BP=471
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQLQQPQQTL
LTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTPQVGDRVLVEATYNPN
MPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRI
VSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPS
CDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVMLMASPSMEDLYHKSC
ALAEDPQELRDGFQHPARLVKETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNC
SIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGKGEDSDVLSINAD
AYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQLELLELEMRARAIKA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CCAR1-CAAP1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	CCAR1	chr10:70514584	chr9:26887511	ENST00000265872	+	12	25	1_249	486.0	1151.0	AR
Hgene	CCAR1	chr10:70514584	chr9:26887511	ENST00000535016	+	11	24	1_249	471.0	1136.0	AR
Hgene	CCAR1	chr10:70514584	chr9:26887511	ENST00000543719	+	11	24	1_249	471.0	1136.0	AR

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CCAR1	chr10:70514584	chr9:26887511	ENST00000265872	+	12	25	643_1150	486.0	1151.0	GATA1
Hgene	CCAR1	chr10:70514584	chr9:26887511	ENST00000535016	+	11	24	643_1150	471.0	1136.0	GATA1
Hgene	CCAR1	chr10:70514584	chr9:26887511	ENST00000543719	+	11	24	643_1150	471.0	1136.0	GATA1
Hgene	CCAR1	chr10:70514584	chr9:26887511	ENST00000265872	+	12	25	203_660	486.0	1151.0	GATA2
Hgene	CCAR1	chr10:70514584	chr9:26887511	ENST00000535016	+	11	24	203_660	471.0	1136.0	GATA2
Hgene	CCAR1	chr10:70514584	chr9:26887511	ENST00000543719	+	11	24	203_660	471.0	1136.0	GATA2

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CCAR1-CAAP1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CCAR1-CAAP1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source