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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCBL2-ZBTB1 (FusionGDB2 ID:13543)

Fusion Gene Summary for CCBL2-ZBTB1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCBL2-ZBTB1
Fusion gene ID: 13543
HgeneTgene
Gene symbol

CCBL2

ZBTB1

Gene ID

56267

22890

Gene namekynurenine aminotransferase 3zinc finger and BTB domain containing 1
SynonymsCCBL2|KAT3|KATIIIZNF909
Cytomap

1p22.2

14q23.3

Type of geneprotein-codingprotein-coding
Descriptionkynurenine--oxoglutarate transaminase 3cysteine-S-conjugate beta-lyase 2kynurenine aminotransferase IIIkynurenine--glyoxylate transaminasekynurenine--oxoglutarate transaminase IIIzinc finger and BTB domain-containing protein 1
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000260508, ENST00000370485, 
ENST00000370491, ENST00000446900, 
ENST00000358738, ENST00000394712, 
ENST00000554015, ENST00000556818, 
Fusion gene scores* DoF score3 X 1 X 3=99 X 2 X 6=108
# samples 38
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/108*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCBL2 [Title/Abstract] AND ZBTB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCBL2(89458268)-ZBTB1(64988205), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZBTB1

GO:0000122

negative regulation of transcription by RNA polymerase II

20797634|21706167

TgeneZBTB1

GO:0042789

mRNA transcription by RNA polymerase II

21706167

TgeneZBTB1

GO:0051260

protein homooligomerization

20797634


check buttonFusion gene breakpoints across CCBL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZBTB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GT-01ACCBL2chr1

89458268

-ZBTB1chr14

64988205

+


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Fusion Gene ORF analysis for CCBL2-ZBTB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000260508ENST00000358738CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
5UTR-5UTRENST00000260508ENST00000394712CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
5UTR-5UTRENST00000260508ENST00000554015CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
5UTR-5UTRENST00000370485ENST00000358738CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
5UTR-5UTRENST00000370485ENST00000394712CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
5UTR-5UTRENST00000370485ENST00000554015CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
5UTR-5UTRENST00000370491ENST00000358738CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
5UTR-5UTRENST00000370491ENST00000394712CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
5UTR-5UTRENST00000370491ENST00000554015CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
5UTR-intronENST00000260508ENST00000556818CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
5UTR-intronENST00000370485ENST00000556818CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
5UTR-intronENST00000370491ENST00000556818CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
intron-5UTRENST00000446900ENST00000358738CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
intron-5UTRENST00000446900ENST00000394712CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
intron-5UTRENST00000446900ENST00000554015CCBL2chr1

89458268

-ZBTB1chr14

64988205

+
intron-intronENST00000446900ENST00000556818CCBL2chr1

89458268

-ZBTB1chr14

64988205

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CCBL2-ZBTB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CCBL2chr189458267-ZBTB1chr1464988204+3.06E-060.9999969
CCBL2chr189458267-ZBTB1chr1464988204+3.06E-060.9999969

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CCBL2-ZBTB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:89458268/:64988205)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CCBL2-ZBTB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CCBL2-ZBTB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCBL2-ZBTB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCBL2-ZBTB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource