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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCDC12-SMC6 (FusionGDB2 ID:13621)

Fusion Gene Summary for CCDC12-SMC6

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC12-SMC6
Fusion gene ID: 13621
HgeneTgene
Gene symbol

CCDC12

SMC6

Gene ID

151903

79677

Gene namecoiled-coil domain containing 12structural maintenance of chromosomes 6
Synonyms-SMC-6|SMC6L1|hSMC6
Cytomap

3p21.31

2p24.2

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 12structural maintenance of chromosomes protein 6SMC protein 6SMC6 structural maintenance of chromosomes 6-like 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000292314, ENST00000425441, 
ENST00000546280, ENST00000605358, 
ENST00000489535, ENST00000351948, 
ENST00000381272, ENST00000402989, 
ENST00000448223, 
Fusion gene scores* DoF score8 X 10 X 4=3204 X 3 X 4=48
# samples 114
** MAII scorelog2(11/320*10)=-1.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC12 [Title/Abstract] AND SMC6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC12(47018127)-SMC6(17906625), # samples:1
Anticipated loss of major functional domain due to fusion event.CCDC12-SMC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSMC6

GO:0006974

cellular response to DNA damage stimulus

11408570|25931565


check buttonFusion gene breakpoints across CCDC12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMC6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A44T-01ACCDC12chr3

47018127

-SMC6chr2

17906625

-


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Fusion Gene ORF analysis for CCDC12-SMC6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000292314ENST00000489535CCDC12chr3

47018127

-SMC6chr2

17906625

-
5CDS-intronENST00000425441ENST00000489535CCDC12chr3

47018127

-SMC6chr2

17906625

-
5CDS-intronENST00000546280ENST00000489535CCDC12chr3

47018127

-SMC6chr2

17906625

-
Frame-shiftENST00000425441ENST00000351948CCDC12chr3

47018127

-SMC6chr2

17906625

-
Frame-shiftENST00000425441ENST00000381272CCDC12chr3

47018127

-SMC6chr2

17906625

-
Frame-shiftENST00000425441ENST00000402989CCDC12chr3

47018127

-SMC6chr2

17906625

-
Frame-shiftENST00000425441ENST00000448223CCDC12chr3

47018127

-SMC6chr2

17906625

-
In-frameENST00000292314ENST00000351948CCDC12chr3

47018127

-SMC6chr2

17906625

-
In-frameENST00000292314ENST00000381272CCDC12chr3

47018127

-SMC6chr2

17906625

-
In-frameENST00000292314ENST00000402989CCDC12chr3

47018127

-SMC6chr2

17906625

-
In-frameENST00000292314ENST00000448223CCDC12chr3

47018127

-SMC6chr2

17906625

-
In-frameENST00000546280ENST00000351948CCDC12chr3

47018127

-SMC6chr2

17906625

-
In-frameENST00000546280ENST00000381272CCDC12chr3

47018127

-SMC6chr2

17906625

-
In-frameENST00000546280ENST00000402989CCDC12chr3

47018127

-SMC6chr2

17906625

-
In-frameENST00000546280ENST00000448223CCDC12chr3

47018127

-SMC6chr2

17906625

-
intron-3CDSENST00000605358ENST00000351948CCDC12chr3

47018127

-SMC6chr2

17906625

-
intron-3CDSENST00000605358ENST00000381272CCDC12chr3

47018127

-SMC6chr2

17906625

-
intron-3CDSENST00000605358ENST00000402989CCDC12chr3

47018127

-SMC6chr2

17906625

-
intron-3CDSENST00000605358ENST00000448223CCDC12chr3

47018127

-SMC6chr2

17906625

-
intron-intronENST00000605358ENST00000489535CCDC12chr3

47018127

-SMC6chr2

17906625

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000292314CCDC12chr347018127-ENST00000402989SMC6chr217906625-284814492795928
ENST00000292314CCDC12chr347018127-ENST00000448223SMC6chr217906625-448314492795928
ENST00000292314CCDC12chr347018127-ENST00000351948SMC6chr217906625-448314492795928
ENST00000292314CCDC12chr347018127-ENST00000381272SMC6chr217906625-289614492795928
ENST00000546280CCDC12chr347018127-ENST00000402989SMC6chr217906625-284814492795928
ENST00000546280CCDC12chr347018127-ENST00000448223SMC6chr217906625-448314492795928
ENST00000546280CCDC12chr347018127-ENST00000351948SMC6chr217906625-448314492795928
ENST00000546280CCDC12chr347018127-ENST00000381272SMC6chr217906625-289614492795928

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000292314ENST00000402989CCDC12chr347018127-SMC6chr217906625-0.0013836190.99861634
ENST00000292314ENST00000448223CCDC12chr347018127-SMC6chr217906625-0.000434310.99956566
ENST00000292314ENST00000351948CCDC12chr347018127-SMC6chr217906625-0.000434310.99956566
ENST00000292314ENST00000381272CCDC12chr347018127-SMC6chr217906625-0.0012744910.9987255
ENST00000546280ENST00000402989CCDC12chr347018127-SMC6chr217906625-0.0013836190.99861634
ENST00000546280ENST00000448223CCDC12chr347018127-SMC6chr217906625-0.000434310.99956566
ENST00000546280ENST00000351948CCDC12chr347018127-SMC6chr217906625-0.000434310.99956566
ENST00000546280ENST00000381272CCDC12chr347018127-SMC6chr217906625-0.0012744910.9987255

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Fusion Genomic Features for CCDC12-SMC6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCDC12-SMC6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:47018127/chr2:17906625)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC12chr3:47018127chr2:17906625ENST00000546280-178_2832167.0Coiled coilOntology_term=ECO:0000255
TgeneSMC6chr3:47018127chr2:17906625ENST00000351948627226_4512081092.0Coiled coilOntology_term=ECO:0000255
TgeneSMC6chr3:47018127chr2:17906625ENST00000351948627660_9142081092.0Coiled coilOntology_term=ECO:0000255
TgeneSMC6chr3:47018127chr2:17906625ENST00000381272829660_9142341118.0Coiled coilOntology_term=ECO:0000255
TgeneSMC6chr3:47018127chr2:17906625ENST00000402989930226_4512081092.0Coiled coilOntology_term=ECO:0000255
TgeneSMC6chr3:47018127chr2:17906625ENST00000402989930660_9142081092.0Coiled coilOntology_term=ECO:0000255
TgeneSMC6chr3:47018127chr2:17906625ENST00000448223728226_4512081092.0Coiled coilOntology_term=ECO:0000255
TgeneSMC6chr3:47018127chr2:17906625ENST00000448223728660_9142081092.0Coiled coilOntology_term=ECO:0000255
TgeneSMC6chr3:47018127chr2:17906625ENST00000351948627987_10222081092.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneSMC6chr3:47018127chr2:17906625ENST00000381272829987_10222341118.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneSMC6chr3:47018127chr2:17906625ENST00000402989930987_10222081092.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneSMC6chr3:47018127chr2:17906625ENST00000448223728987_10222081092.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneSMC6chr3:47018127chr2:17906625ENST00000351948627452_6592081092.0RegionNote=Flexible hinge
TgeneSMC6chr3:47018127chr2:17906625ENST00000381272829452_6592341118.0RegionNote=Flexible hinge
TgeneSMC6chr3:47018127chr2:17906625ENST00000402989930452_6592081092.0RegionNote=Flexible hinge
TgeneSMC6chr3:47018127chr2:17906625ENST00000448223728452_6592081092.0RegionNote=Flexible hinge

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC12chr3:47018127chr2:17906625ENST00000546280-17117_14432167.0Coiled coilOntology_term=ECO:0000255
TgeneSMC6chr3:47018127chr2:17906625ENST00000381272829226_4512341118.0Coiled coilOntology_term=ECO:0000255
TgeneSMC6chr3:47018127chr2:17906625ENST0000035194862776_832081092.0Nucleotide bindingATP
TgeneSMC6chr3:47018127chr2:17906625ENST0000038127282976_832341118.0Nucleotide bindingATP
TgeneSMC6chr3:47018127chr2:17906625ENST0000040298993076_832081092.0Nucleotide bindingATP
TgeneSMC6chr3:47018127chr2:17906625ENST0000044822372876_832081092.0Nucleotide bindingATP


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Fusion Gene Sequence for CCDC12-SMC6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13621_13621_1_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000292314_SMC6_chr2_17906625_ENST00000351948_length(transcript)=4483nt_BP=144nt
GCCTGCGCGATGCAAGACGGGAGAAAAGGAGGGGCGTACGCGGGCAAGATGGAGGCAACTACGGCTGGTGTGGGCCGGCTAGAGGAAGAG
GCGTTGCGGCGAAAGGAACGGCTGAAGGCCCTACGGGAGAAAACCGGGCGCAAGTTCTTCATGAAAGCAACGCAACTTGAACAGATGAAG
GAAGATTATTCATACATTATGGAAACGAAAGAAAGAACAAAGGAGCAGATACATCAAGGAGAAGAGCGGCTTACTGAACTAAAGCGCCAG
TGTGTAGAGAAAGAGGAACGTTTTCAAAGTATTGCTGGTTTAAGTACAATGAAGACTAATTTAGAGTCCTTGAAACATGAAATGGCTTGG
GCAGTGGTCAATGAAATTGAAAAACAATTGAATGCCATCAGAGATAATATCAAAATTGGAGAAGATCGTGCTGCTAGACTTGACAGGAAA
ATGGAAGAACAGCAGGTCAGACTTAATGAGGCAGAACAAAAGTACAAGGATATTCAAGACAAACTAGAAAAGATTAGTGAAGAGACAAAT
GCACGAGCACCAGAATGTATGGCATTGAAAGCAGATGTTGTTGCTAAGAAAAGGGCCTATAATGAAGCTGAGGTTTTATATAACCGATCC
TTAAACGAATATAAAGCATTAAAGAAAGATGATGAGCAGCTTTGTAAACGAATTGAAGAGCTGAAAAAAAGTACTGACCAATCTTTGGAA
CCTGAACGGTTGGAAAGACAAAAAAAAATATCTTGGTTAAAAGAGAGAGTAAAGGCCTTTCAAAATCAAGAAAATTCAGTCAATCAAGAG
ATCGAACAGTTTCAGCAAGCCATAGAAAAGGACAAAGAAGAACATGGCAAAATTAAGAGAGAAGAATTAGATGTGAAGCATGCACTGAGC
TACAATCAGAGGCAACTGAAAGAATTGAAAGATAGTAAAACTGATCGACTCAAAAGATTTGGCCCTAATGTTCCAGCTCTTCTTGAAGCC
ATAGATGATGCTTATAGACAAGGACATTTTACCTATAAACCTGTAGGCCCTTTAGGAGCTTGCATTCATCTTCGGGACCCAGAACTTGCT
TTGGCTATTGAATCTTGCTTAAAAGGGCTTCTGCAGGCCTATTGTTGCCATAATCATGCTGATGAAAGGGTCCTTCAGGCACTCATGAAA
AGGTTTTATTTACCAGGGACCTCACGGCCACCGATAATAGTTTCTGAGTTTCGGAATGAGATATATGATGTAAGACACAGAGCTGCTTAT
CATCCAGACTTTCCAACAGTTCTGACAGCTTTAGAAATAGATAATGCGGTTGTGGCAAATAGCCTAATTGACATGAGAGGCATAGAGACA
GTGCTACTAATCAAAAATAATTCTGTAGCTCGTGCAGTAATGCAGTCCCAAAAGCCACCCAAAAATTGTAGAGAAGCTTTTACTGCTGAT
GGTGATCAAGTTTTTGCAGGACGTTATTATTCATCTGAAAATACAAGACCTAAGTTCCTAAGCAGAGATGTGGATTCTGAAATAAGTGAC
TTGGAGAATGAGGTTGAAAATAAGACGGCCCAGATATTAAATCTTCAGCAACATTTATCTGCCCTTGAAAAAGATATTAAACACAATGAG
GAACTTCTTAAAAGGTGCCAACTACATTATAAAGAACTAAAGATGAAAATAAGAAAAAATATTTCTGAAATTCGGGAACTTGAGAACATA
GAAGAACACCAGTCTGTAGATATTGCAACTTTGGAAGATGAAGCTCAGGAAAATAAAAGCAAAATGAAAATGGTTGAGGAACATATGGAG
CAACAAAAAGAAAATATGGAGCATCTTAAAAGTCTGAAAATAGAAGCAGAAAATAAGTATGATGCAATTAAATTCAAAATTAATCAACTA
TCGGAGCTAGCAGACCCACTTAAGGATGAATTAAACCTTGCTGATTCTGAAGTGGATAACCAAAAACGAGGGAAACGACATTATGAAGAA
AAACAAAAAGAACACTTGGATACCTTAAATAAAAAGAAACGAGAACTGGATATGAAAGAGAAAGAACTAGAGGAGAAAATGTCACAAGCA
AGACAAATCTGCCCAGAGCGTATAGAAGTAGAAAAATCTGCATCAATTCTGGACAAAGAAATTAATCGATTAAGGCAGAAGATACAGGCA
GAACATGCTAGTCATGGAGATCGAGAGGAAATAATGAGGCAGTACCAAGAAGCAAGAGAGACCTATCTTGATCTGGATAGTAAAGTGAGG
ACTTTAAAAAAGTTTATTAAATTACTGGGAGAAATCATGGAGCACAGATTCAAGACATATCAACAATTTAGAAGGTGTTTGACTTTACGA
TGCAAATTATACTTTGACAACTTACTATCTCAGCGGGCCTATTGTGGAAAAATGAATTTTGACCACAAGAATGAAACTCTAAGTATATCA
GTTCAGCCTGGAGAAGGAAATAAAGCTGCTTTCAATGACATGAGAGCCTTGTCTGGAGGTGAACGTTCTTTCTCCACAGTGTGTTTTATT
CTTTCCCTGTGGTCCATCGCAGAATCTCCTTTCAGATGCCTGGATGAATTTGATGTCTACATGGATATGGTTAATAGGAGAATTGCCATG
GACTTGATACTGAAGATGGCAGATTCCCAGCGTTTTAGACAGTTTATCTTGCTCACACCTCAAAGCATGAGTTCACTTCCATCCAGTAAA
CTGATAAGAATTCTCCGAATGTCTGATCCTGAAAGAGGACAAACTACATTGCCTTTCAGACCTGTGACTCAAGAAGAAGATGATGACCAA
AGGTGATTTGTAACTTAACATGCCTTGTCCTGATGTTGAAGGATTTGTGAAGGGAAAAAAAATTCTGGACTCTTTGATATAATAAAATGA
GACTGGAGGCATTCTGAAATGAAAGAAACTCCTTTATATATCCAACCACAATCAAACATATAAATAAGCCTGGAAAACCAACTACAACCT
GCAATTTAAGATTACTATTACTTTAAGAAAATCAATTTCATAGTATTGGTTTTAAATCTTTTTAAGTTTTTTTAATACGATCTATTTTTA
TAGGTTCTTTTTCAGAAGTAAAATTTTGTACATATATACATGTACATATCTGTTTAGTTTGGGTTCATTTCTATAACATTTTGTAAGAAA
ATAAAAGTTTGAGCACCTGATTATATTTAGTTTTGCTTTTCCAGATATTACATTCTATAGTTACCAAAAATGGTTGAAGGGAGGGATTTC
TCATTGCAGAGGGTGGGGTGCAAGGGAATAAGACACTTGTACGGAACACTGAAGCTTTGCCAACTTCTACACATGCCTTTTTTGCAGTCC
TTTAACTGTCCACCCTACCAAGAGCTTATAACCAGTATCAGAACTGGATAATGACGCAGTTTTTCACTCTGACCTCCATCATGCTTGCCT
GATTTAAAAGCCCTCAGTTTGCAGTCCAGGGACTGTTCAGGCTTGTCCTCAGCTGAGAGGACACAGGCTAGAGGGACTGTGCAGAACCAG
GCTGGGAGAAGGGCTGGGAAAACTGGGAGTGGAGGGTGGATCCTCATGGAGCAGGAGAGTAGCTCATGGCTCCAGGAGCCTGAGGCCATG
CAGTTGATGGTGAGCTGACATCAATTCTAAGACTCATCCTAATTGAGGGGTGTTAAAAAGTGTGCTGCTTAGAATGACCAAATATAGTTA
TTGTAAAAAATGATATTTATGAACTTTTTATTTTAGAAAACATGAATTTTATTGCTCCCTGTATTATTTGTTTGATACTAGGATTCATGC
TAAACTTTTTAAGAATGTATTGGATATCAAGAAGCATTCCTTACATTAGTAGCAATAAATATTAGAATAAATATGAAATTGAACTATTTT
CAGAAAAAGGGCAGTATATTAAGAGCAGGGACTGTTCTCTAGTTATTGAGGAAAACTGGACTTTGTTTGTGTTTTTGGTGGAGGAAGAAG
TTTAAGATACTTTAGTCTTAAATTGAGGTTTGCCAAATGAGAAGTTCAAAAACTTGGGCTTTCTAATCAGAATTTCCAGGAGGAGGAAAG
TGTGTGCTGAATATTTTAAACATTTCCCACTGATCATACAAAGTCTGATTTTTAAATTTACACTTATAATGCCTTTGTATTAAAATTATT
TTTAACATGTGCTTTTCCAAATTAAAAATGAAGTAGAGTATACCAAATGCATAAACTTTCATTAGCTAAGGAACTCATGTCTGAATTTTG
TTGTAGTTTTGAATGTTGTGCTCTTTCATACAGAATGGGAAACATAATCCTCAGGTATCCCAGCATCTCTTGTTGAATTGAAGATTATTC
ATTGCTTTGGCCTCACAAAGTTTTGATTTCAACTATCATAAGTGAAAATATCTTCCTTTAATGTTCTAAGTAGTGATAATATTACTAGAA

>13621_13621_1_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000292314_SMC6_chr2_17906625_ENST00000351948_length(amino acids)=928AA_BP=45
MQDGRKGGAYAGKMEATTAGVGRLEEEALRRKERLKALREKTGRKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVE
KEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARA
PECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQ
FQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAI
ESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLL
IKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL
KRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSEL
ADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHA
SHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQP
GEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIR

--------------------------------------------------------------
>13621_13621_2_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000292314_SMC6_chr2_17906625_ENST00000381272_length(transcript)=2896nt_BP=144nt
GCCTGCGCGATGCAAGACGGGAGAAAAGGAGGGGCGTACGCGGGCAAGATGGAGGCAACTACGGCTGGTGTGGGCCGGCTAGAGGAAGAG
GCGTTGCGGCGAAAGGAACGGCTGAAGGCCCTACGGGAGAAAACCGGGCGCAAGTTCTTCATGAAAGCAACGCAACTTGAACAGATGAAG
GAAGATTATTCATACATTATGGAAACGAAAGAAAGAACAAAGGAGCAGATACATCAAGGAGAAGAGCGGCTTACTGAACTAAAGCGCCAG
TGTGTAGAGAAAGAGGAACGTTTTCAAAGTATTGCTGGTTTAAGTACAATGAAGACTAATTTAGAGTCCTTGAAACATGAAATGGCTTGG
GCAGTGGTCAATGAAATTGAAAAACAATTGAATGCCATCAGAGATAATATCAAAATTGGAGAAGATCGTGCTGCTAGACTTGACAGGAAA
ATGGAAGAACAGCAGGTCAGACTTAATGAGGCAGAACAAAAGTACAAGGATATTCAAGACAAACTAGAAAAGATTAGTGAAGAGACAAAT
GCACGAGCACCAGAATGTATGGCATTGAAAGCAGATGTTGTTGCTAAGAAAAGGGCCTATAATGAAGCTGAGGTTTTATATAACCGATCC
TTAAACGAATATAAAGCATTAAAGAAAGATGATGAGCAGCTTTGTAAACGAATTGAAGAGCTGAAAAAAAGTACTGACCAATCTTTGGAA
CCTGAACGGTTGGAAAGACAAAAAAAAATATCTTGGTTAAAAGAGAGAGTAAAGGCCTTTCAAAATCAAGAAAATTCAGTCAATCAAGAG
ATCGAACAGTTTCAGCAAGCCATAGAAAAGGACAAAGAAGAACATGGCAAAATTAAGAGAGAAGAATTAGATGTGAAGCATGCACTGAGC
TACAATCAGAGGCAACTGAAAGAATTGAAAGATAGTAAAACTGATCGACTCAAAAGATTTGGCCCTAATGTTCCAGCTCTTCTTGAAGCC
ATAGATGATGCTTATAGACAAGGACATTTTACCTATAAACCTGTAGGCCCTTTAGGAGCTTGCATTCATCTTCGGGACCCAGAACTTGCT
TTGGCTATTGAATCTTGCTTAAAAGGGCTTCTGCAGGCCTATTGTTGCCATAATCATGCTGATGAAAGGGTCCTTCAGGCACTCATGAAA
AGGTTTTATTTACCAGGGACCTCACGGCCACCGATAATAGTTTCTGAGTTTCGGAATGAGATATATGATGTAAGACACAGAGCTGCTTAT
CATCCAGACTTTCCAACAGTTCTGACAGCTTTAGAAATAGATAATGCGGTTGTGGCAAATAGCCTAATTGACATGAGAGGCATAGAGACA
GTGCTACTAATCAAAAATAATTCTGTAGCTCGTGCAGTAATGCAGTCCCAAAAGCCACCCAAAAATTGTAGAGAAGCTTTTACTGCTGAT
GGTGATCAAGTTTTTGCAGGACGTTATTATTCATCTGAAAATACAAGACCTAAGTTCCTAAGCAGAGATGTGGATTCTGAAATAAGTGAC
TTGGAGAATGAGGTTGAAAATAAGACGGCCCAGATATTAAATCTTCAGCAACATTTATCTGCCCTTGAAAAAGATATTAAACACAATGAG
GAACTTCTTAAAAGGTGCCAACTACATTATAAAGAACTAAAGATGAAAATAAGAAAAAATATTTCTGAAATTCGGGAACTTGAGAACATA
GAAGAACACCAGTCTGTAGATATTGCAACTTTGGAAGATGAAGCTCAGGAAAATAAAAGCAAAATGAAAATGGTTGAGGAACATATGGAG
CAACAAAAAGAAAATATGGAGCATCTTAAAAGTCTGAAAATAGAAGCAGAAAATAAGTATGATGCAATTAAATTCAAAATTAATCAACTA
TCGGAGCTAGCAGACCCACTTAAGGATGAATTAAACCTTGCTGATTCTGAAGTGGATAACCAAAAACGAGGGAAACGACATTATGAAGAA
AAACAAAAAGAACACTTGGATACCTTAAATAAAAAGAAACGAGAACTGGATATGAAAGAGAAAGAACTAGAGGAGAAAATGTCACAAGCA
AGACAAATCTGCCCAGAGCGTATAGAAGTAGAAAAATCTGCATCAATTCTGGACAAAGAAATTAATCGATTAAGGCAGAAGATACAGGCA
GAACATGCTAGTCATGGAGATCGAGAGGAAATAATGAGGCAGTACCAAGAAGCAAGAGAGACCTATCTTGATCTGGATAGTAAAGTGAGG
ACTTTAAAAAAGTTTATTAAATTACTGGGAGAAATCATGGAGCACAGATTCAAGACATATCAACAATTTAGAAGGTGTTTGACTTTACGA
TGCAAATTATACTTTGACAACTTACTATCTCAGCGGGCCTATTGTGGAAAAATGAATTTTGACCACAAGAATGAAACTCTAAGTATATCA
GTTCAGCCTGGAGAAGGAAATAAAGCTGCTTTCAATGACATGAGAGCCTTGTCTGGAGGTGAACGTTCTTTCTCCACAGTGTGTTTTATT
CTTTCCCTGTGGTCCATCGCAGAATCTCCTTTCAGATGCCTGGATGAATTTGATGTCTACATGGATATGGTTAATAGGAGAATTGCCATG
GACTTGATACTGAAGATGGCAGATTCCCAGCGTTTTAGACAGTTTATCTTGCTCACACCTCAAAGCATGAGTTCACTTCCATCCAGTAAA
CTGATAAGAATTCTCCGAATGTCTGATCCTGAAAGAGGACAAACTACATTGCCTTTCAGACCTGTGACTCAAGAAGAAGATGATGACCAA
AGGTGATTTGTAACTTAACATGCCTTGTCCTGATGTTGAAGGATTTGTGAAGGGAAAAAAAATTCTGGACTCTTTGATATAATAAAATGA

>13621_13621_2_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000292314_SMC6_chr2_17906625_ENST00000381272_length(amino acids)=928AA_BP=45
MQDGRKGGAYAGKMEATTAGVGRLEEEALRRKERLKALREKTGRKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVE
KEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARA
PECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQ
FQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAI
ESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLL
IKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL
KRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSEL
ADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHA
SHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQP
GEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIR

--------------------------------------------------------------
>13621_13621_3_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000292314_SMC6_chr2_17906625_ENST00000402989_length(transcript)=2848nt_BP=144nt
GCCTGCGCGATGCAAGACGGGAGAAAAGGAGGGGCGTACGCGGGCAAGATGGAGGCAACTACGGCTGGTGTGGGCCGGCTAGAGGAAGAG
GCGTTGCGGCGAAAGGAACGGCTGAAGGCCCTACGGGAGAAAACCGGGCGCAAGTTCTTCATGAAAGCAACGCAACTTGAACAGATGAAG
GAAGATTATTCATACATTATGGAAACGAAAGAAAGAACAAAGGAGCAGATACATCAAGGAGAAGAGCGGCTTACTGAACTAAAGCGCCAG
TGTGTAGAGAAAGAGGAACGTTTTCAAAGTATTGCTGGTTTAAGTACAATGAAGACTAATTTAGAGTCCTTGAAACATGAAATGGCTTGG
GCAGTGGTCAATGAAATTGAAAAACAATTGAATGCCATCAGAGATAATATCAAAATTGGAGAAGATCGTGCTGCTAGACTTGACAGGAAA
ATGGAAGAACAGCAGGTCAGACTTAATGAGGCAGAACAAAAGTACAAGGATATTCAAGACAAACTAGAAAAGATTAGTGAAGAGACAAAT
GCACGAGCACCAGAATGTATGGCATTGAAAGCAGATGTTGTTGCTAAGAAAAGGGCCTATAATGAAGCTGAGGTTTTATATAACCGATCC
TTAAACGAATATAAAGCATTAAAGAAAGATGATGAGCAGCTTTGTAAACGAATTGAAGAGCTGAAAAAAAGTACTGACCAATCTTTGGAA
CCTGAACGGTTGGAAAGACAAAAAAAAATATCTTGGTTAAAAGAGAGAGTAAAGGCCTTTCAAAATCAAGAAAATTCAGTCAATCAAGAG
ATCGAACAGTTTCAGCAAGCCATAGAAAAGGACAAAGAAGAACATGGCAAAATTAAGAGAGAAGAATTAGATGTGAAGCATGCACTGAGC
TACAATCAGAGGCAACTGAAAGAATTGAAAGATAGTAAAACTGATCGACTCAAAAGATTTGGCCCTAATGTTCCAGCTCTTCTTGAAGCC
ATAGATGATGCTTATAGACAAGGACATTTTACCTATAAACCTGTAGGCCCTTTAGGAGCTTGCATTCATCTTCGGGACCCAGAACTTGCT
TTGGCTATTGAATCTTGCTTAAAAGGGCTTCTGCAGGCCTATTGTTGCCATAATCATGCTGATGAAAGGGTCCTTCAGGCACTCATGAAA
AGGTTTTATTTACCAGGGACCTCACGGCCACCGATAATAGTTTCTGAGTTTCGGAATGAGATATATGATGTAAGACACAGAGCTGCTTAT
CATCCAGACTTTCCAACAGTTCTGACAGCTTTAGAAATAGATAATGCGGTTGTGGCAAATAGCCTAATTGACATGAGAGGCATAGAGACA
GTGCTACTAATCAAAAATAATTCTGTAGCTCGTGCAGTAATGCAGTCCCAAAAGCCACCCAAAAATTGTAGAGAAGCTTTTACTGCTGAT
GGTGATCAAGTTTTTGCAGGACGTTATTATTCATCTGAAAATACAAGACCTAAGTTCCTAAGCAGAGATGTGGATTCTGAAATAAGTGAC
TTGGAGAATGAGGTTGAAAATAAGACGGCCCAGATATTAAATCTTCAGCAACATTTATCTGCCCTTGAAAAAGATATTAAACACAATGAG
GAACTTCTTAAAAGGTGCCAACTACATTATAAAGAACTAAAGATGAAAATAAGAAAAAATATTTCTGAAATTCGGGAACTTGAGAACATA
GAAGAACACCAGTCTGTAGATATTGCAACTTTGGAAGATGAAGCTCAGGAAAATAAAAGCAAAATGAAAATGGTTGAGGAACATATGGAG
CAACAAAAAGAAAATATGGAGCATCTTAAAAGTCTGAAAATAGAAGCAGAAAATAAGTATGATGCAATTAAATTCAAAATTAATCAACTA
TCGGAGCTAGCAGACCCACTTAAGGATGAATTAAACCTTGCTGATTCTGAAGTGGATAACCAAAAACGAGGGAAACGACATTATGAAGAA
AAACAAAAAGAACACTTGGATACCTTAAATAAAAAGAAACGAGAACTGGATATGAAAGAGAAAGAACTAGAGGAGAAAATGTCACAAGCA
AGACAAATCTGCCCAGAGCGTATAGAAGTAGAAAAATCTGCATCAATTCTGGACAAAGAAATTAATCGATTAAGGCAGAAGATACAGGCA
GAACATGCTAGTCATGGAGATCGAGAGGAAATAATGAGGCAGTACCAAGAAGCAAGAGAGACCTATCTTGATCTGGATAGTAAAGTGAGG
ACTTTAAAAAAGTTTATTAAATTACTGGGAGAAATCATGGAGCACAGATTCAAGACATATCAACAATTTAGAAGGTGTTTGACTTTACGA
TGCAAATTATACTTTGACAACTTACTATCTCAGCGGGCCTATTGTGGAAAAATGAATTTTGACCACAAGAATGAAACTCTAAGTATATCA
GTTCAGCCTGGAGAAGGAAATAAAGCTGCTTTCAATGACATGAGAGCCTTGTCTGGAGGTGAACGTTCTTTCTCCACAGTGTGTTTTATT
CTTTCCCTGTGGTCCATCGCAGAATCTCCTTTCAGATGCCTGGATGAATTTGATGTCTACATGGATATGGTTAATAGGAGAATTGCCATG
GACTTGATACTGAAGATGGCAGATTCCCAGCGTTTTAGACAGTTTATCTTGCTCACACCTCAAAGCATGAGTTCACTTCCATCCAGTAAA
CTGATAAGAATTCTCCGAATGTCTGATCCTGAAAGAGGACAAACTACATTGCCTTTCAGACCTGTGACTCAAGAAGAAGATGATGACCAA

>13621_13621_3_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000292314_SMC6_chr2_17906625_ENST00000402989_length(amino acids)=928AA_BP=45
MQDGRKGGAYAGKMEATTAGVGRLEEEALRRKERLKALREKTGRKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVE
KEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARA
PECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQ
FQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAI
ESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLL
IKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL
KRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSEL
ADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHA
SHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQP
GEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIR

--------------------------------------------------------------
>13621_13621_4_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000292314_SMC6_chr2_17906625_ENST00000448223_length(transcript)=4483nt_BP=144nt
GCCTGCGCGATGCAAGACGGGAGAAAAGGAGGGGCGTACGCGGGCAAGATGGAGGCAACTACGGCTGGTGTGGGCCGGCTAGAGGAAGAG
GCGTTGCGGCGAAAGGAACGGCTGAAGGCCCTACGGGAGAAAACCGGGCGCAAGTTCTTCATGAAAGCAACGCAACTTGAACAGATGAAG
GAAGATTATTCATACATTATGGAAACGAAAGAAAGAACAAAGGAGCAGATACATCAAGGAGAAGAGCGGCTTACTGAACTAAAGCGCCAG
TGTGTAGAGAAAGAGGAACGTTTTCAAAGTATTGCTGGTTTAAGTACAATGAAGACTAATTTAGAGTCCTTGAAACATGAAATGGCTTGG
GCAGTGGTCAATGAAATTGAAAAACAATTGAATGCCATCAGAGATAATATCAAAATTGGAGAAGATCGTGCTGCTAGACTTGACAGGAAA
ATGGAAGAACAGCAGGTCAGACTTAATGAGGCAGAACAAAAGTACAAGGATATTCAAGACAAACTAGAAAAGATTAGTGAAGAGACAAAT
GCACGAGCACCAGAATGTATGGCATTGAAAGCAGATGTTGTTGCTAAGAAAAGGGCCTATAATGAAGCTGAGGTTTTATATAACCGATCC
TTAAACGAATATAAAGCATTAAAGAAAGATGATGAGCAGCTTTGTAAACGAATTGAAGAGCTGAAAAAAAGTACTGACCAATCTTTGGAA
CCTGAACGGTTGGAAAGACAAAAAAAAATATCTTGGTTAAAAGAGAGAGTAAAGGCCTTTCAAAATCAAGAAAATTCAGTCAATCAAGAG
ATCGAACAGTTTCAGCAAGCCATAGAAAAGGACAAAGAAGAACATGGCAAAATTAAGAGAGAAGAATTAGATGTGAAGCATGCACTGAGC
TACAATCAGAGGCAACTGAAAGAATTGAAAGATAGTAAAACTGATCGACTCAAAAGATTTGGCCCTAATGTTCCAGCTCTTCTTGAAGCC
ATAGATGATGCTTATAGACAAGGACATTTTACCTATAAACCTGTAGGCCCTTTAGGAGCTTGCATTCATCTTCGGGACCCAGAACTTGCT
TTGGCTATTGAATCTTGCTTAAAAGGGCTTCTGCAGGCCTATTGTTGCCATAATCATGCTGATGAAAGGGTCCTTCAGGCACTCATGAAA
AGGTTTTATTTACCAGGGACCTCACGGCCACCGATAATAGTTTCTGAGTTTCGGAATGAGATATATGATGTAAGACACAGAGCTGCTTAT
CATCCAGACTTTCCAACAGTTCTGACAGCTTTAGAAATAGATAATGCGGTTGTGGCAAATAGCCTAATTGACATGAGAGGCATAGAGACA
GTGCTACTAATCAAAAATAATTCTGTAGCTCGTGCAGTAATGCAGTCCCAAAAGCCACCCAAAAATTGTAGAGAAGCTTTTACTGCTGAT
GGTGATCAAGTTTTTGCAGGACGTTATTATTCATCTGAAAATACAAGACCTAAGTTCCTAAGCAGAGATGTGGATTCTGAAATAAGTGAC
TTGGAGAATGAGGTTGAAAATAAGACGGCCCAGATATTAAATCTTCAGCAACATTTATCTGCCCTTGAAAAAGATATTAAACACAATGAG
GAACTTCTTAAAAGGTGCCAACTACATTATAAAGAACTAAAGATGAAAATAAGAAAAAATATTTCTGAAATTCGGGAACTTGAGAACATA
GAAGAACACCAGTCTGTAGATATTGCAACTTTGGAAGATGAAGCTCAGGAAAATAAAAGCAAAATGAAAATGGTTGAGGAACATATGGAG
CAACAAAAAGAAAATATGGAGCATCTTAAAAGTCTGAAAATAGAAGCAGAAAATAAGTATGATGCAATTAAATTCAAAATTAATCAACTA
TCGGAGCTAGCAGACCCACTTAAGGATGAATTAAACCTTGCTGATTCTGAAGTGGATAACCAAAAACGAGGGAAACGACATTATGAAGAA
AAACAAAAAGAACACTTGGATACCTTAAATAAAAAGAAACGAGAACTGGATATGAAAGAGAAAGAACTAGAGGAGAAAATGTCACAAGCA
AGACAAATCTGCCCAGAGCGTATAGAAGTAGAAAAATCTGCATCAATTCTGGACAAAGAAATTAATCGATTAAGGCAGAAGATACAGGCA
GAACATGCTAGTCATGGAGATCGAGAGGAAATAATGAGGCAGTACCAAGAAGCAAGAGAGACCTATCTTGATCTGGATAGTAAAGTGAGG
ACTTTAAAAAAGTTTATTAAATTACTGGGAGAAATCATGGAGCACAGATTCAAGACATATCAACAATTTAGAAGGTGTTTGACTTTACGA
TGCAAATTATACTTTGACAACTTACTATCTCAGCGGGCCTATTGTGGAAAAATGAATTTTGACCACAAGAATGAAACTCTAAGTATATCA
GTTCAGCCTGGAGAAGGAAATAAAGCTGCTTTCAATGACATGAGAGCCTTGTCTGGAGGTGAACGTTCTTTCTCCACAGTGTGTTTTATT
CTTTCCCTGTGGTCCATCGCAGAATCTCCTTTCAGATGCCTGGATGAATTTGATGTCTACATGGATATGGTTAATAGGAGAATTGCCATG
GACTTGATACTGAAGATGGCAGATTCCCAGCGTTTTAGACAGTTTATCTTGCTCACACCTCAAAGCATGAGTTCACTTCCATCCAGTAAA
CTGATAAGAATTCTCCGAATGTCTGATCCTGAAAGAGGACAAACTACATTGCCTTTCAGACCTGTGACTCAAGAAGAAGATGATGACCAA
AGGTGATTTGTAACTTAACATGCCTTGTCCTGATGTTGAAGGATTTGTGAAGGGAAAAAAAATTCTGGACTCTTTGATATAATAAAATGA
GACTGGAGGCATTCTGAAATGAAAGAAACTCCTTTATATATCCAACCACAATCAAACATATAAATAAGCCTGGAAAACCAACTACAACCT
GCAATTTAAGATTACTATTACTTTAAGAAAATCAATTTCATAGTATTGGTTTTAAATCTTTTTAAGTTTTTTTAATACGATCTATTTTTA
TAGGTTCTTTTTCAGAAGTAAAATTTTGTACATATATACATGTACATATCTGTTTAGTTTGGGTTCATTTCTATAACATTTTGTAAGAAA
ATAAAAGTTTGAGCACCTGATTATATTTAGTTTTGCTTTTCCAGATATTACATTCTATAGTTACCAAAAATGGTTGAAGGGAGGGATTTC
TCATTGCAGAGGGTGGGGTGCAAGGGAATAAGACACTTGTACGGAACACTGAAGCTTTGCCAACTTCTACACATGCCTTTTTTGCAGTCC
TTTAACTGTCCACCCTACCAAGAGCTTATAACCAGTATCAGAACTGGATAATGACGCAGTTTTTCACTCTGACCTCCATCATGCTTGCCT
GATTTAAAAGCCCTCAGTTTGCAGTCCAGGGACTGTTCAGGCTTGTCCTCAGCTGAGAGGACACAGGCTAGAGGGACTGTGCAGAACCAG
GCTGGGAGAAGGGCTGGGAAAACTGGGAGTGGAGGGTGGATCCTCATGGAGCAGGAGAGTAGCTCATGGCTCCAGGAGCCTGAGGCCATG
CAGTTGATGGTGAGCTGACATCAATTCTAAGACTCATCCTAATTGAGGGGTGTTAAAAAGTGTGCTGCTTAGAATGACCAAATATAGTTA
TTGTAAAAAATGATATTTATGAACTTTTTATTTTAGAAAACATGAATTTTATTGCTCCCTGTATTATTTGTTTGATACTAGGATTCATGC
TAAACTTTTTAAGAATGTATTGGATATCAAGAAGCATTCCTTACATTAGTAGCAATAAATATTAGAATAAATATGAAATTGAACTATTTT
CAGAAAAAGGGCAGTATATTAAGAGCAGGGACTGTTCTCTAGTTATTGAGGAAAACTGGACTTTGTTTGTGTTTTTGGTGGAGGAAGAAG
TTTAAGATACTTTAGTCTTAAATTGAGGTTTGCCAAATGAGAAGTTCAAAAACTTGGGCTTTCTAATCAGAATTTCCAGGAGGAGGAAAG
TGTGTGCTGAATATTTTAAACATTTCCCACTGATCATACAAAGTCTGATTTTTAAATTTACACTTATAATGCCTTTGTATTAAAATTATT
TTTAACATGTGCTTTTCCAAATTAAAAATGAAGTAGAGTATACCAAATGCATAAACTTTCATTAGCTAAGGAACTCATGTCTGAATTTTG
TTGTAGTTTTGAATGTTGTGCTCTTTCATACAGAATGGGAAACATAATCCTCAGGTATCCCAGCATCTCTTGTTGAATTGAAGATTATTC
ATTGCTTTGGCCTCACAAAGTTTTGATTTCAACTATCATAAGTGAAAATATCTTCCTTTAATGTTCTAAGTAGTGATAATATTACTAGAA

>13621_13621_4_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000292314_SMC6_chr2_17906625_ENST00000448223_length(amino acids)=928AA_BP=45
MQDGRKGGAYAGKMEATTAGVGRLEEEALRRKERLKALREKTGRKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVE
KEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARA
PECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQ
FQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAI
ESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLL
IKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL
KRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSEL
ADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHA
SHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQP
GEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIR

--------------------------------------------------------------
>13621_13621_5_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000546280_SMC6_chr2_17906625_ENST00000351948_length(transcript)=4483nt_BP=144nt
GCCTGCGCGATGCAAGACGGGAGAAAAGGAGGGGCGTACGCGGGCAAGATGGAGGCAACTACGGCTGGTGTGGGCCGGCTAGAGGAAGAG
GCGTTGCGGCGAAAGGAACGGCTGAAGGCCCTACGGGAGAAAACCGGGCGCAAGTTCTTCATGAAAGCAACGCAACTTGAACAGATGAAG
GAAGATTATTCATACATTATGGAAACGAAAGAAAGAACAAAGGAGCAGATACATCAAGGAGAAGAGCGGCTTACTGAACTAAAGCGCCAG
TGTGTAGAGAAAGAGGAACGTTTTCAAAGTATTGCTGGTTTAAGTACAATGAAGACTAATTTAGAGTCCTTGAAACATGAAATGGCTTGG
GCAGTGGTCAATGAAATTGAAAAACAATTGAATGCCATCAGAGATAATATCAAAATTGGAGAAGATCGTGCTGCTAGACTTGACAGGAAA
ATGGAAGAACAGCAGGTCAGACTTAATGAGGCAGAACAAAAGTACAAGGATATTCAAGACAAACTAGAAAAGATTAGTGAAGAGACAAAT
GCACGAGCACCAGAATGTATGGCATTGAAAGCAGATGTTGTTGCTAAGAAAAGGGCCTATAATGAAGCTGAGGTTTTATATAACCGATCC
TTAAACGAATATAAAGCATTAAAGAAAGATGATGAGCAGCTTTGTAAACGAATTGAAGAGCTGAAAAAAAGTACTGACCAATCTTTGGAA
CCTGAACGGTTGGAAAGACAAAAAAAAATATCTTGGTTAAAAGAGAGAGTAAAGGCCTTTCAAAATCAAGAAAATTCAGTCAATCAAGAG
ATCGAACAGTTTCAGCAAGCCATAGAAAAGGACAAAGAAGAACATGGCAAAATTAAGAGAGAAGAATTAGATGTGAAGCATGCACTGAGC
TACAATCAGAGGCAACTGAAAGAATTGAAAGATAGTAAAACTGATCGACTCAAAAGATTTGGCCCTAATGTTCCAGCTCTTCTTGAAGCC
ATAGATGATGCTTATAGACAAGGACATTTTACCTATAAACCTGTAGGCCCTTTAGGAGCTTGCATTCATCTTCGGGACCCAGAACTTGCT
TTGGCTATTGAATCTTGCTTAAAAGGGCTTCTGCAGGCCTATTGTTGCCATAATCATGCTGATGAAAGGGTCCTTCAGGCACTCATGAAA
AGGTTTTATTTACCAGGGACCTCACGGCCACCGATAATAGTTTCTGAGTTTCGGAATGAGATATATGATGTAAGACACAGAGCTGCTTAT
CATCCAGACTTTCCAACAGTTCTGACAGCTTTAGAAATAGATAATGCGGTTGTGGCAAATAGCCTAATTGACATGAGAGGCATAGAGACA
GTGCTACTAATCAAAAATAATTCTGTAGCTCGTGCAGTAATGCAGTCCCAAAAGCCACCCAAAAATTGTAGAGAAGCTTTTACTGCTGAT
GGTGATCAAGTTTTTGCAGGACGTTATTATTCATCTGAAAATACAAGACCTAAGTTCCTAAGCAGAGATGTGGATTCTGAAATAAGTGAC
TTGGAGAATGAGGTTGAAAATAAGACGGCCCAGATATTAAATCTTCAGCAACATTTATCTGCCCTTGAAAAAGATATTAAACACAATGAG
GAACTTCTTAAAAGGTGCCAACTACATTATAAAGAACTAAAGATGAAAATAAGAAAAAATATTTCTGAAATTCGGGAACTTGAGAACATA
GAAGAACACCAGTCTGTAGATATTGCAACTTTGGAAGATGAAGCTCAGGAAAATAAAAGCAAAATGAAAATGGTTGAGGAACATATGGAG
CAACAAAAAGAAAATATGGAGCATCTTAAAAGTCTGAAAATAGAAGCAGAAAATAAGTATGATGCAATTAAATTCAAAATTAATCAACTA
TCGGAGCTAGCAGACCCACTTAAGGATGAATTAAACCTTGCTGATTCTGAAGTGGATAACCAAAAACGAGGGAAACGACATTATGAAGAA
AAACAAAAAGAACACTTGGATACCTTAAATAAAAAGAAACGAGAACTGGATATGAAAGAGAAAGAACTAGAGGAGAAAATGTCACAAGCA
AGACAAATCTGCCCAGAGCGTATAGAAGTAGAAAAATCTGCATCAATTCTGGACAAAGAAATTAATCGATTAAGGCAGAAGATACAGGCA
GAACATGCTAGTCATGGAGATCGAGAGGAAATAATGAGGCAGTACCAAGAAGCAAGAGAGACCTATCTTGATCTGGATAGTAAAGTGAGG
ACTTTAAAAAAGTTTATTAAATTACTGGGAGAAATCATGGAGCACAGATTCAAGACATATCAACAATTTAGAAGGTGTTTGACTTTACGA
TGCAAATTATACTTTGACAACTTACTATCTCAGCGGGCCTATTGTGGAAAAATGAATTTTGACCACAAGAATGAAACTCTAAGTATATCA
GTTCAGCCTGGAGAAGGAAATAAAGCTGCTTTCAATGACATGAGAGCCTTGTCTGGAGGTGAACGTTCTTTCTCCACAGTGTGTTTTATT
CTTTCCCTGTGGTCCATCGCAGAATCTCCTTTCAGATGCCTGGATGAATTTGATGTCTACATGGATATGGTTAATAGGAGAATTGCCATG
GACTTGATACTGAAGATGGCAGATTCCCAGCGTTTTAGACAGTTTATCTTGCTCACACCTCAAAGCATGAGTTCACTTCCATCCAGTAAA
CTGATAAGAATTCTCCGAATGTCTGATCCTGAAAGAGGACAAACTACATTGCCTTTCAGACCTGTGACTCAAGAAGAAGATGATGACCAA
AGGTGATTTGTAACTTAACATGCCTTGTCCTGATGTTGAAGGATTTGTGAAGGGAAAAAAAATTCTGGACTCTTTGATATAATAAAATGA
GACTGGAGGCATTCTGAAATGAAAGAAACTCCTTTATATATCCAACCACAATCAAACATATAAATAAGCCTGGAAAACCAACTACAACCT
GCAATTTAAGATTACTATTACTTTAAGAAAATCAATTTCATAGTATTGGTTTTAAATCTTTTTAAGTTTTTTTAATACGATCTATTTTTA
TAGGTTCTTTTTCAGAAGTAAAATTTTGTACATATATACATGTACATATCTGTTTAGTTTGGGTTCATTTCTATAACATTTTGTAAGAAA
ATAAAAGTTTGAGCACCTGATTATATTTAGTTTTGCTTTTCCAGATATTACATTCTATAGTTACCAAAAATGGTTGAAGGGAGGGATTTC
TCATTGCAGAGGGTGGGGTGCAAGGGAATAAGACACTTGTACGGAACACTGAAGCTTTGCCAACTTCTACACATGCCTTTTTTGCAGTCC
TTTAACTGTCCACCCTACCAAGAGCTTATAACCAGTATCAGAACTGGATAATGACGCAGTTTTTCACTCTGACCTCCATCATGCTTGCCT
GATTTAAAAGCCCTCAGTTTGCAGTCCAGGGACTGTTCAGGCTTGTCCTCAGCTGAGAGGACACAGGCTAGAGGGACTGTGCAGAACCAG
GCTGGGAGAAGGGCTGGGAAAACTGGGAGTGGAGGGTGGATCCTCATGGAGCAGGAGAGTAGCTCATGGCTCCAGGAGCCTGAGGCCATG
CAGTTGATGGTGAGCTGACATCAATTCTAAGACTCATCCTAATTGAGGGGTGTTAAAAAGTGTGCTGCTTAGAATGACCAAATATAGTTA
TTGTAAAAAATGATATTTATGAACTTTTTATTTTAGAAAACATGAATTTTATTGCTCCCTGTATTATTTGTTTGATACTAGGATTCATGC
TAAACTTTTTAAGAATGTATTGGATATCAAGAAGCATTCCTTACATTAGTAGCAATAAATATTAGAATAAATATGAAATTGAACTATTTT
CAGAAAAAGGGCAGTATATTAAGAGCAGGGACTGTTCTCTAGTTATTGAGGAAAACTGGACTTTGTTTGTGTTTTTGGTGGAGGAAGAAG
TTTAAGATACTTTAGTCTTAAATTGAGGTTTGCCAAATGAGAAGTTCAAAAACTTGGGCTTTCTAATCAGAATTTCCAGGAGGAGGAAAG
TGTGTGCTGAATATTTTAAACATTTCCCACTGATCATACAAAGTCTGATTTTTAAATTTACACTTATAATGCCTTTGTATTAAAATTATT
TTTAACATGTGCTTTTCCAAATTAAAAATGAAGTAGAGTATACCAAATGCATAAACTTTCATTAGCTAAGGAACTCATGTCTGAATTTTG
TTGTAGTTTTGAATGTTGTGCTCTTTCATACAGAATGGGAAACATAATCCTCAGGTATCCCAGCATCTCTTGTTGAATTGAAGATTATTC
ATTGCTTTGGCCTCACAAAGTTTTGATTTCAACTATCATAAGTGAAAATATCTTCCTTTAATGTTCTAAGTAGTGATAATATTACTAGAA

>13621_13621_5_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000546280_SMC6_chr2_17906625_ENST00000351948_length(amino acids)=928AA_BP=45
MQDGRKGGAYAGKMEATTAGVGRLEEEALRRKERLKALREKTGRKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVE
KEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARA
PECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQ
FQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAI
ESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLL
IKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL
KRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSEL
ADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHA
SHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQP
GEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIR

--------------------------------------------------------------
>13621_13621_6_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000546280_SMC6_chr2_17906625_ENST00000381272_length(transcript)=2896nt_BP=144nt
GCCTGCGCGATGCAAGACGGGAGAAAAGGAGGGGCGTACGCGGGCAAGATGGAGGCAACTACGGCTGGTGTGGGCCGGCTAGAGGAAGAG
GCGTTGCGGCGAAAGGAACGGCTGAAGGCCCTACGGGAGAAAACCGGGCGCAAGTTCTTCATGAAAGCAACGCAACTTGAACAGATGAAG
GAAGATTATTCATACATTATGGAAACGAAAGAAAGAACAAAGGAGCAGATACATCAAGGAGAAGAGCGGCTTACTGAACTAAAGCGCCAG
TGTGTAGAGAAAGAGGAACGTTTTCAAAGTATTGCTGGTTTAAGTACAATGAAGACTAATTTAGAGTCCTTGAAACATGAAATGGCTTGG
GCAGTGGTCAATGAAATTGAAAAACAATTGAATGCCATCAGAGATAATATCAAAATTGGAGAAGATCGTGCTGCTAGACTTGACAGGAAA
ATGGAAGAACAGCAGGTCAGACTTAATGAGGCAGAACAAAAGTACAAGGATATTCAAGACAAACTAGAAAAGATTAGTGAAGAGACAAAT
GCACGAGCACCAGAATGTATGGCATTGAAAGCAGATGTTGTTGCTAAGAAAAGGGCCTATAATGAAGCTGAGGTTTTATATAACCGATCC
TTAAACGAATATAAAGCATTAAAGAAAGATGATGAGCAGCTTTGTAAACGAATTGAAGAGCTGAAAAAAAGTACTGACCAATCTTTGGAA
CCTGAACGGTTGGAAAGACAAAAAAAAATATCTTGGTTAAAAGAGAGAGTAAAGGCCTTTCAAAATCAAGAAAATTCAGTCAATCAAGAG
ATCGAACAGTTTCAGCAAGCCATAGAAAAGGACAAAGAAGAACATGGCAAAATTAAGAGAGAAGAATTAGATGTGAAGCATGCACTGAGC
TACAATCAGAGGCAACTGAAAGAATTGAAAGATAGTAAAACTGATCGACTCAAAAGATTTGGCCCTAATGTTCCAGCTCTTCTTGAAGCC
ATAGATGATGCTTATAGACAAGGACATTTTACCTATAAACCTGTAGGCCCTTTAGGAGCTTGCATTCATCTTCGGGACCCAGAACTTGCT
TTGGCTATTGAATCTTGCTTAAAAGGGCTTCTGCAGGCCTATTGTTGCCATAATCATGCTGATGAAAGGGTCCTTCAGGCACTCATGAAA
AGGTTTTATTTACCAGGGACCTCACGGCCACCGATAATAGTTTCTGAGTTTCGGAATGAGATATATGATGTAAGACACAGAGCTGCTTAT
CATCCAGACTTTCCAACAGTTCTGACAGCTTTAGAAATAGATAATGCGGTTGTGGCAAATAGCCTAATTGACATGAGAGGCATAGAGACA
GTGCTACTAATCAAAAATAATTCTGTAGCTCGTGCAGTAATGCAGTCCCAAAAGCCACCCAAAAATTGTAGAGAAGCTTTTACTGCTGAT
GGTGATCAAGTTTTTGCAGGACGTTATTATTCATCTGAAAATACAAGACCTAAGTTCCTAAGCAGAGATGTGGATTCTGAAATAAGTGAC
TTGGAGAATGAGGTTGAAAATAAGACGGCCCAGATATTAAATCTTCAGCAACATTTATCTGCCCTTGAAAAAGATATTAAACACAATGAG
GAACTTCTTAAAAGGTGCCAACTACATTATAAAGAACTAAAGATGAAAATAAGAAAAAATATTTCTGAAATTCGGGAACTTGAGAACATA
GAAGAACACCAGTCTGTAGATATTGCAACTTTGGAAGATGAAGCTCAGGAAAATAAAAGCAAAATGAAAATGGTTGAGGAACATATGGAG
CAACAAAAAGAAAATATGGAGCATCTTAAAAGTCTGAAAATAGAAGCAGAAAATAAGTATGATGCAATTAAATTCAAAATTAATCAACTA
TCGGAGCTAGCAGACCCACTTAAGGATGAATTAAACCTTGCTGATTCTGAAGTGGATAACCAAAAACGAGGGAAACGACATTATGAAGAA
AAACAAAAAGAACACTTGGATACCTTAAATAAAAAGAAACGAGAACTGGATATGAAAGAGAAAGAACTAGAGGAGAAAATGTCACAAGCA
AGACAAATCTGCCCAGAGCGTATAGAAGTAGAAAAATCTGCATCAATTCTGGACAAAGAAATTAATCGATTAAGGCAGAAGATACAGGCA
GAACATGCTAGTCATGGAGATCGAGAGGAAATAATGAGGCAGTACCAAGAAGCAAGAGAGACCTATCTTGATCTGGATAGTAAAGTGAGG
ACTTTAAAAAAGTTTATTAAATTACTGGGAGAAATCATGGAGCACAGATTCAAGACATATCAACAATTTAGAAGGTGTTTGACTTTACGA
TGCAAATTATACTTTGACAACTTACTATCTCAGCGGGCCTATTGTGGAAAAATGAATTTTGACCACAAGAATGAAACTCTAAGTATATCA
GTTCAGCCTGGAGAAGGAAATAAAGCTGCTTTCAATGACATGAGAGCCTTGTCTGGAGGTGAACGTTCTTTCTCCACAGTGTGTTTTATT
CTTTCCCTGTGGTCCATCGCAGAATCTCCTTTCAGATGCCTGGATGAATTTGATGTCTACATGGATATGGTTAATAGGAGAATTGCCATG
GACTTGATACTGAAGATGGCAGATTCCCAGCGTTTTAGACAGTTTATCTTGCTCACACCTCAAAGCATGAGTTCACTTCCATCCAGTAAA
CTGATAAGAATTCTCCGAATGTCTGATCCTGAAAGAGGACAAACTACATTGCCTTTCAGACCTGTGACTCAAGAAGAAGATGATGACCAA
AGGTGATTTGTAACTTAACATGCCTTGTCCTGATGTTGAAGGATTTGTGAAGGGAAAAAAAATTCTGGACTCTTTGATATAATAAAATGA

>13621_13621_6_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000546280_SMC6_chr2_17906625_ENST00000381272_length(amino acids)=928AA_BP=45
MQDGRKGGAYAGKMEATTAGVGRLEEEALRRKERLKALREKTGRKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVE
KEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARA
PECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQ
FQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAI
ESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLL
IKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL
KRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSEL
ADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHA
SHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQP
GEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIR

--------------------------------------------------------------
>13621_13621_7_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000546280_SMC6_chr2_17906625_ENST00000402989_length(transcript)=2848nt_BP=144nt
GCCTGCGCGATGCAAGACGGGAGAAAAGGAGGGGCGTACGCGGGCAAGATGGAGGCAACTACGGCTGGTGTGGGCCGGCTAGAGGAAGAG
GCGTTGCGGCGAAAGGAACGGCTGAAGGCCCTACGGGAGAAAACCGGGCGCAAGTTCTTCATGAAAGCAACGCAACTTGAACAGATGAAG
GAAGATTATTCATACATTATGGAAACGAAAGAAAGAACAAAGGAGCAGATACATCAAGGAGAAGAGCGGCTTACTGAACTAAAGCGCCAG
TGTGTAGAGAAAGAGGAACGTTTTCAAAGTATTGCTGGTTTAAGTACAATGAAGACTAATTTAGAGTCCTTGAAACATGAAATGGCTTGG
GCAGTGGTCAATGAAATTGAAAAACAATTGAATGCCATCAGAGATAATATCAAAATTGGAGAAGATCGTGCTGCTAGACTTGACAGGAAA
ATGGAAGAACAGCAGGTCAGACTTAATGAGGCAGAACAAAAGTACAAGGATATTCAAGACAAACTAGAAAAGATTAGTGAAGAGACAAAT
GCACGAGCACCAGAATGTATGGCATTGAAAGCAGATGTTGTTGCTAAGAAAAGGGCCTATAATGAAGCTGAGGTTTTATATAACCGATCC
TTAAACGAATATAAAGCATTAAAGAAAGATGATGAGCAGCTTTGTAAACGAATTGAAGAGCTGAAAAAAAGTACTGACCAATCTTTGGAA
CCTGAACGGTTGGAAAGACAAAAAAAAATATCTTGGTTAAAAGAGAGAGTAAAGGCCTTTCAAAATCAAGAAAATTCAGTCAATCAAGAG
ATCGAACAGTTTCAGCAAGCCATAGAAAAGGACAAAGAAGAACATGGCAAAATTAAGAGAGAAGAATTAGATGTGAAGCATGCACTGAGC
TACAATCAGAGGCAACTGAAAGAATTGAAAGATAGTAAAACTGATCGACTCAAAAGATTTGGCCCTAATGTTCCAGCTCTTCTTGAAGCC
ATAGATGATGCTTATAGACAAGGACATTTTACCTATAAACCTGTAGGCCCTTTAGGAGCTTGCATTCATCTTCGGGACCCAGAACTTGCT
TTGGCTATTGAATCTTGCTTAAAAGGGCTTCTGCAGGCCTATTGTTGCCATAATCATGCTGATGAAAGGGTCCTTCAGGCACTCATGAAA
AGGTTTTATTTACCAGGGACCTCACGGCCACCGATAATAGTTTCTGAGTTTCGGAATGAGATATATGATGTAAGACACAGAGCTGCTTAT
CATCCAGACTTTCCAACAGTTCTGACAGCTTTAGAAATAGATAATGCGGTTGTGGCAAATAGCCTAATTGACATGAGAGGCATAGAGACA
GTGCTACTAATCAAAAATAATTCTGTAGCTCGTGCAGTAATGCAGTCCCAAAAGCCACCCAAAAATTGTAGAGAAGCTTTTACTGCTGAT
GGTGATCAAGTTTTTGCAGGACGTTATTATTCATCTGAAAATACAAGACCTAAGTTCCTAAGCAGAGATGTGGATTCTGAAATAAGTGAC
TTGGAGAATGAGGTTGAAAATAAGACGGCCCAGATATTAAATCTTCAGCAACATTTATCTGCCCTTGAAAAAGATATTAAACACAATGAG
GAACTTCTTAAAAGGTGCCAACTACATTATAAAGAACTAAAGATGAAAATAAGAAAAAATATTTCTGAAATTCGGGAACTTGAGAACATA
GAAGAACACCAGTCTGTAGATATTGCAACTTTGGAAGATGAAGCTCAGGAAAATAAAAGCAAAATGAAAATGGTTGAGGAACATATGGAG
CAACAAAAAGAAAATATGGAGCATCTTAAAAGTCTGAAAATAGAAGCAGAAAATAAGTATGATGCAATTAAATTCAAAATTAATCAACTA
TCGGAGCTAGCAGACCCACTTAAGGATGAATTAAACCTTGCTGATTCTGAAGTGGATAACCAAAAACGAGGGAAACGACATTATGAAGAA
AAACAAAAAGAACACTTGGATACCTTAAATAAAAAGAAACGAGAACTGGATATGAAAGAGAAAGAACTAGAGGAGAAAATGTCACAAGCA
AGACAAATCTGCCCAGAGCGTATAGAAGTAGAAAAATCTGCATCAATTCTGGACAAAGAAATTAATCGATTAAGGCAGAAGATACAGGCA
GAACATGCTAGTCATGGAGATCGAGAGGAAATAATGAGGCAGTACCAAGAAGCAAGAGAGACCTATCTTGATCTGGATAGTAAAGTGAGG
ACTTTAAAAAAGTTTATTAAATTACTGGGAGAAATCATGGAGCACAGATTCAAGACATATCAACAATTTAGAAGGTGTTTGACTTTACGA
TGCAAATTATACTTTGACAACTTACTATCTCAGCGGGCCTATTGTGGAAAAATGAATTTTGACCACAAGAATGAAACTCTAAGTATATCA
GTTCAGCCTGGAGAAGGAAATAAAGCTGCTTTCAATGACATGAGAGCCTTGTCTGGAGGTGAACGTTCTTTCTCCACAGTGTGTTTTATT
CTTTCCCTGTGGTCCATCGCAGAATCTCCTTTCAGATGCCTGGATGAATTTGATGTCTACATGGATATGGTTAATAGGAGAATTGCCATG
GACTTGATACTGAAGATGGCAGATTCCCAGCGTTTTAGACAGTTTATCTTGCTCACACCTCAAAGCATGAGTTCACTTCCATCCAGTAAA
CTGATAAGAATTCTCCGAATGTCTGATCCTGAAAGAGGACAAACTACATTGCCTTTCAGACCTGTGACTCAAGAAGAAGATGATGACCAA

>13621_13621_7_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000546280_SMC6_chr2_17906625_ENST00000402989_length(amino acids)=928AA_BP=45
MQDGRKGGAYAGKMEATTAGVGRLEEEALRRKERLKALREKTGRKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVE
KEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARA
PECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQ
FQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAI
ESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLL
IKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL
KRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSEL
ADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHA
SHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQP
GEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIR

--------------------------------------------------------------
>13621_13621_8_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000546280_SMC6_chr2_17906625_ENST00000448223_length(transcript)=4483nt_BP=144nt
GCCTGCGCGATGCAAGACGGGAGAAAAGGAGGGGCGTACGCGGGCAAGATGGAGGCAACTACGGCTGGTGTGGGCCGGCTAGAGGAAGAG
GCGTTGCGGCGAAAGGAACGGCTGAAGGCCCTACGGGAGAAAACCGGGCGCAAGTTCTTCATGAAAGCAACGCAACTTGAACAGATGAAG
GAAGATTATTCATACATTATGGAAACGAAAGAAAGAACAAAGGAGCAGATACATCAAGGAGAAGAGCGGCTTACTGAACTAAAGCGCCAG
TGTGTAGAGAAAGAGGAACGTTTTCAAAGTATTGCTGGTTTAAGTACAATGAAGACTAATTTAGAGTCCTTGAAACATGAAATGGCTTGG
GCAGTGGTCAATGAAATTGAAAAACAATTGAATGCCATCAGAGATAATATCAAAATTGGAGAAGATCGTGCTGCTAGACTTGACAGGAAA
ATGGAAGAACAGCAGGTCAGACTTAATGAGGCAGAACAAAAGTACAAGGATATTCAAGACAAACTAGAAAAGATTAGTGAAGAGACAAAT
GCACGAGCACCAGAATGTATGGCATTGAAAGCAGATGTTGTTGCTAAGAAAAGGGCCTATAATGAAGCTGAGGTTTTATATAACCGATCC
TTAAACGAATATAAAGCATTAAAGAAAGATGATGAGCAGCTTTGTAAACGAATTGAAGAGCTGAAAAAAAGTACTGACCAATCTTTGGAA
CCTGAACGGTTGGAAAGACAAAAAAAAATATCTTGGTTAAAAGAGAGAGTAAAGGCCTTTCAAAATCAAGAAAATTCAGTCAATCAAGAG
ATCGAACAGTTTCAGCAAGCCATAGAAAAGGACAAAGAAGAACATGGCAAAATTAAGAGAGAAGAATTAGATGTGAAGCATGCACTGAGC
TACAATCAGAGGCAACTGAAAGAATTGAAAGATAGTAAAACTGATCGACTCAAAAGATTTGGCCCTAATGTTCCAGCTCTTCTTGAAGCC
ATAGATGATGCTTATAGACAAGGACATTTTACCTATAAACCTGTAGGCCCTTTAGGAGCTTGCATTCATCTTCGGGACCCAGAACTTGCT
TTGGCTATTGAATCTTGCTTAAAAGGGCTTCTGCAGGCCTATTGTTGCCATAATCATGCTGATGAAAGGGTCCTTCAGGCACTCATGAAA
AGGTTTTATTTACCAGGGACCTCACGGCCACCGATAATAGTTTCTGAGTTTCGGAATGAGATATATGATGTAAGACACAGAGCTGCTTAT
CATCCAGACTTTCCAACAGTTCTGACAGCTTTAGAAATAGATAATGCGGTTGTGGCAAATAGCCTAATTGACATGAGAGGCATAGAGACA
GTGCTACTAATCAAAAATAATTCTGTAGCTCGTGCAGTAATGCAGTCCCAAAAGCCACCCAAAAATTGTAGAGAAGCTTTTACTGCTGAT
GGTGATCAAGTTTTTGCAGGACGTTATTATTCATCTGAAAATACAAGACCTAAGTTCCTAAGCAGAGATGTGGATTCTGAAATAAGTGAC
TTGGAGAATGAGGTTGAAAATAAGACGGCCCAGATATTAAATCTTCAGCAACATTTATCTGCCCTTGAAAAAGATATTAAACACAATGAG
GAACTTCTTAAAAGGTGCCAACTACATTATAAAGAACTAAAGATGAAAATAAGAAAAAATATTTCTGAAATTCGGGAACTTGAGAACATA
GAAGAACACCAGTCTGTAGATATTGCAACTTTGGAAGATGAAGCTCAGGAAAATAAAAGCAAAATGAAAATGGTTGAGGAACATATGGAG
CAACAAAAAGAAAATATGGAGCATCTTAAAAGTCTGAAAATAGAAGCAGAAAATAAGTATGATGCAATTAAATTCAAAATTAATCAACTA
TCGGAGCTAGCAGACCCACTTAAGGATGAATTAAACCTTGCTGATTCTGAAGTGGATAACCAAAAACGAGGGAAACGACATTATGAAGAA
AAACAAAAAGAACACTTGGATACCTTAAATAAAAAGAAACGAGAACTGGATATGAAAGAGAAAGAACTAGAGGAGAAAATGTCACAAGCA
AGACAAATCTGCCCAGAGCGTATAGAAGTAGAAAAATCTGCATCAATTCTGGACAAAGAAATTAATCGATTAAGGCAGAAGATACAGGCA
GAACATGCTAGTCATGGAGATCGAGAGGAAATAATGAGGCAGTACCAAGAAGCAAGAGAGACCTATCTTGATCTGGATAGTAAAGTGAGG
ACTTTAAAAAAGTTTATTAAATTACTGGGAGAAATCATGGAGCACAGATTCAAGACATATCAACAATTTAGAAGGTGTTTGACTTTACGA
TGCAAATTATACTTTGACAACTTACTATCTCAGCGGGCCTATTGTGGAAAAATGAATTTTGACCACAAGAATGAAACTCTAAGTATATCA
GTTCAGCCTGGAGAAGGAAATAAAGCTGCTTTCAATGACATGAGAGCCTTGTCTGGAGGTGAACGTTCTTTCTCCACAGTGTGTTTTATT
CTTTCCCTGTGGTCCATCGCAGAATCTCCTTTCAGATGCCTGGATGAATTTGATGTCTACATGGATATGGTTAATAGGAGAATTGCCATG
GACTTGATACTGAAGATGGCAGATTCCCAGCGTTTTAGACAGTTTATCTTGCTCACACCTCAAAGCATGAGTTCACTTCCATCCAGTAAA
CTGATAAGAATTCTCCGAATGTCTGATCCTGAAAGAGGACAAACTACATTGCCTTTCAGACCTGTGACTCAAGAAGAAGATGATGACCAA
AGGTGATTTGTAACTTAACATGCCTTGTCCTGATGTTGAAGGATTTGTGAAGGGAAAAAAAATTCTGGACTCTTTGATATAATAAAATGA
GACTGGAGGCATTCTGAAATGAAAGAAACTCCTTTATATATCCAACCACAATCAAACATATAAATAAGCCTGGAAAACCAACTACAACCT
GCAATTTAAGATTACTATTACTTTAAGAAAATCAATTTCATAGTATTGGTTTTAAATCTTTTTAAGTTTTTTTAATACGATCTATTTTTA
TAGGTTCTTTTTCAGAAGTAAAATTTTGTACATATATACATGTACATATCTGTTTAGTTTGGGTTCATTTCTATAACATTTTGTAAGAAA
ATAAAAGTTTGAGCACCTGATTATATTTAGTTTTGCTTTTCCAGATATTACATTCTATAGTTACCAAAAATGGTTGAAGGGAGGGATTTC
TCATTGCAGAGGGTGGGGTGCAAGGGAATAAGACACTTGTACGGAACACTGAAGCTTTGCCAACTTCTACACATGCCTTTTTTGCAGTCC
TTTAACTGTCCACCCTACCAAGAGCTTATAACCAGTATCAGAACTGGATAATGACGCAGTTTTTCACTCTGACCTCCATCATGCTTGCCT
GATTTAAAAGCCCTCAGTTTGCAGTCCAGGGACTGTTCAGGCTTGTCCTCAGCTGAGAGGACACAGGCTAGAGGGACTGTGCAGAACCAG
GCTGGGAGAAGGGCTGGGAAAACTGGGAGTGGAGGGTGGATCCTCATGGAGCAGGAGAGTAGCTCATGGCTCCAGGAGCCTGAGGCCATG
CAGTTGATGGTGAGCTGACATCAATTCTAAGACTCATCCTAATTGAGGGGTGTTAAAAAGTGTGCTGCTTAGAATGACCAAATATAGTTA
TTGTAAAAAATGATATTTATGAACTTTTTATTTTAGAAAACATGAATTTTATTGCTCCCTGTATTATTTGTTTGATACTAGGATTCATGC
TAAACTTTTTAAGAATGTATTGGATATCAAGAAGCATTCCTTACATTAGTAGCAATAAATATTAGAATAAATATGAAATTGAACTATTTT
CAGAAAAAGGGCAGTATATTAAGAGCAGGGACTGTTCTCTAGTTATTGAGGAAAACTGGACTTTGTTTGTGTTTTTGGTGGAGGAAGAAG
TTTAAGATACTTTAGTCTTAAATTGAGGTTTGCCAAATGAGAAGTTCAAAAACTTGGGCTTTCTAATCAGAATTTCCAGGAGGAGGAAAG
TGTGTGCTGAATATTTTAAACATTTCCCACTGATCATACAAAGTCTGATTTTTAAATTTACACTTATAATGCCTTTGTATTAAAATTATT
TTTAACATGTGCTTTTCCAAATTAAAAATGAAGTAGAGTATACCAAATGCATAAACTTTCATTAGCTAAGGAACTCATGTCTGAATTTTG
TTGTAGTTTTGAATGTTGTGCTCTTTCATACAGAATGGGAAACATAATCCTCAGGTATCCCAGCATCTCTTGTTGAATTGAAGATTATTC
ATTGCTTTGGCCTCACAAAGTTTTGATTTCAACTATCATAAGTGAAAATATCTTCCTTTAATGTTCTAAGTAGTGATAATATTACTAGAA

>13621_13621_8_CCDC12-SMC6_CCDC12_chr3_47018127_ENST00000546280_SMC6_chr2_17906625_ENST00000448223_length(amino acids)=928AA_BP=45
MQDGRKGGAYAGKMEATTAGVGRLEEEALRRKERLKALREKTGRKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVE
KEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARA
PECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQ
FQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAI
ESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLL
IKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL
KRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSEL
ADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHA
SHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQP
GEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCDC12-SMC6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCDC12-SMC6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCDC12-SMC6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource