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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCDC174-ECHDC1 (FusionGDB2 ID:13719)

Fusion Gene Summary for CCDC174-ECHDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC174-ECHDC1
Fusion gene ID: 13719
HgeneTgene
Gene symbol

CCDC174

ECHDC1

Gene ID

51244

55862

Gene namecoiled-coil domain containing 174ethylmalonyl-CoA decarboxylase 1
SynonymsC3orf19|HSPC212|IHPM|IHPMRHEL-S-76|MMCD|dJ351K20.2
Cytomap

3p25.1

6q22.33

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 174ethylmalonyl-CoA decarboxylaseenoyl CoA hydratase domain containing 1enoyl Coenzyme A hydratase domain containing 1enoyl-CoA hydratase domain-containing protein 1epididymis secretory protein Li 76methylmalonyl-CoA decarboxylase
Modification date2020031320200313
UniProtAcc

Q6PII3

Q9NTX5

Ensembl transtripts involved in fusion geneENST00000303688, ENST00000383794, 
ENST00000476763, 		ENST00000309620, 
ENST00000368289, ENST00000368291, 
ENST00000430841, ENST00000454591, 
ENST00000528402, ENST00000531967, 
ENST00000488087, ENST00000474289, 
ENST00000454859, 
Fusion gene scores* DoF score4 X 4 X 2=328 X 7 X 6=336
# samples 411
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/336*10)=-1.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC174 [Title/Abstract] AND ECHDC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC174(14708454)-ECHDC1(127611422), # samples:2
Anticipated loss of major functional domain due to fusion event.CCDC174-ECHDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CCDC174 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ECHDC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-7153-01ACCDC174chr3

14708454

+ECHDC1chr6

127611422

-


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Fusion Gene ORF analysis for CCDC174-ECHDC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000303688ENST00000309620CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000303688ENST00000368289CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000303688ENST00000368291CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000303688ENST00000430841CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000303688ENST00000454591CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000303688ENST00000528402CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000303688ENST00000531967CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000383794ENST00000309620CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000383794ENST00000368289CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000383794ENST00000368291CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000383794ENST00000430841CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000383794ENST00000454591CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000383794ENST00000528402CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-3UTRENST00000383794ENST00000531967CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-5UTRENST00000303688ENST00000488087CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
5CDS-5UTRENST00000383794ENST00000488087CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
Frame-shiftENST00000303688ENST00000474289CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
Frame-shiftENST00000383794ENST00000474289CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
In-frameENST00000303688ENST00000454859CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
In-frameENST00000383794ENST00000454859CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
intron-3CDSENST00000476763ENST00000454859CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
intron-3CDSENST00000476763ENST00000474289CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
intron-3UTRENST00000476763ENST00000309620CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
intron-3UTRENST00000476763ENST00000368289CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
intron-3UTRENST00000476763ENST00000368291CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
intron-3UTRENST00000476763ENST00000430841CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
intron-3UTRENST00000476763ENST00000454591CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
intron-3UTRENST00000476763ENST00000528402CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
intron-3UTRENST00000476763ENST00000531967CCDC174chr3

14708454

+ECHDC1chr6

127611422

-
intron-5UTRENST00000476763ENST00000488087CCDC174chr3

14708454

+ECHDC1chr6

127611422

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000303688CCDC174chr314708454+ENST00000454859ECHDC1chr6127611422-236579722801259
ENST00000383794CCDC174chr314708454+ENST00000454859ECHDC1chr6127611422-236579722801259

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000303688ENST00000454859CCDC174chr314708454+ECHDC1chr6127611422-0.000415030.999585
ENST00000383794ENST00000454859CCDC174chr314708454+ECHDC1chr6127611422-0.000415030.999585

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Fusion Genomic Features for CCDC174-ECHDC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCDC174-ECHDC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:14708454/chr6:127611422)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC174

Q6PII3

ECHDC1

Q9NTX5

FUNCTION: Probably involved in neuronal development. {ECO:0000269|PubMed:26358778}.FUNCTION: Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity). {ECO:0000250|UniProtKB:Q9D9V3, ECO:0000269|PubMed:22016388}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC174chr3:14708454chr6:127611422ENST00000383794+71163_99241468.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC174chr3:14708454chr6:127611422ENST00000383794+711219_224241468.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC174chr3:14708454chr6:127611422ENST00000383794+711267_309241468.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for CCDC174-ECHDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13719_13719_1_CCDC174-ECHDC1_CCDC174_chr3_14708454_ENST00000303688_ECHDC1_chr6_127611422_ENST00000454859_length(transcript)=2365nt_BP=797nt
GACGGAGGTAGGCTTACGAGGCCTGTGTCGGGTAGAAAGGGTCCTTCCTGGACCGGGACCCTCTGCCACGACCATGGACCGTAGGAAAAA
GCCTTTGGACGTCACGGCCTCCTCGTTGGTAGATCTTAAGGCTGAACTCTTCCGAAAGCAAGAAGAATTCAAACAAGAAAAACTTCTAAA
AGATTCTGGAGTTTTTGGAAAACCAAAAACAACTAACAAGAAACCAAGTATCTGGAGCAAACAGAATGTAGGCGTTTCAAATCGAGCTGA
GAAGGATGCTGAACAGAAGATTGAAGAACAGAAGACTTTAGACAAAGCAAGGGAAAAATTGGAAGAAAAAGCCAAATTATATGAAAAAAT
GACTAAAGGAGACTTTATAGATGAAGAAGTAGAGGATATGTACCTTGTGGATTTCACACAGAAGATCATAGACAAGCGCAAAGAAATGGA
GGCATCTGGTGCCCATAGAGATTCTCAAAAGGCAGGAGAAAGGGACGACGATGAGGAAAACCTTCCTGAGGGAGAGATCCCTCCTCCCCA
AGACCCCAGTGAAGAATGGGTGGATTACGTGGACTCTTTGGGGCGTTCCCGGCGCTGTATGAGAAAGGATTTGCCAGATCTGCTGGAGAT
GGATAAAAATCTTCAGGGGAGACTTTTTATTAGTCCTGCTAATGAAAAAACCCTATTATCTGAAGATATGAGAAAAGAACTTCAGCGCCA
GCAATGGGAGGAAGAAGAAAGAGAGGCCCTGAAGAGGCCCATGGGGCCCGTACATTATGAAGACATTCGGGAAAATGGTTAATGACTCCA
GAGAGTAAGATCAGATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGA
CAAGCTCTCAAAGTGTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCA
GATGAAACTAAATCTCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCT
GTTTGTTCAGGCAGAGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTA
GAGGCTATTGCTAAGAAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATA
AATGTTAAATGATATTAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGA
ACTCATTTACCTCATTTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAA
AAATTATTGCTGTCAATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCT
GGCGTTACTTTTCATACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGG
GAGGTATCAGGGAACAAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGC
CCTTCATTTAAAAAAAGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCT
ACTAAACAGTGGTAGCCATGACATGGAAAGTCAACTGATTCTACAATTGGACATTCATTTGTGTGCCCTGGAATTTCCAACTAGTAATAA
ACAACTACTGTTGATGTAGTTTTAAACCACTTGAAGGGACTCATGAAGCATCCTGCAACATAAATTTGCATTTTTACATCAGATTTCTTT
TTTTTCCTGAAAAACAACTAACCTTCTAACAACTATCTTTCAAAAGTAAATGTAATAAAAATGCACAACATAAAATGTTTATGATCCCAG
CAATACACTTTTTAAAAAATGTGAAAGTCAAAGAATTAAGTTCTAGTTCTGACTCATCACAAGAGGTCAAAAGTATTTGCTACTGTAACA
TTCAATTCACATTTGAGAATCATGGTAAAAATAACTTGCATTTGCCTTACCATCATGATCCTACTGTTGAGTTAGGAAAATATGGTTAGA
CAGACTCACATTACTTTTTTTCAGAGGTAAACTCTAGATTACTGTGTCAACCCAATACTATTTGGCCATAGATGTAAAAACTACCAAATA

>13719_13719_1_CCDC174-ECHDC1_CCDC174_chr3_14708454_ENST00000303688_ECHDC1_chr6_127611422_ENST00000454859_length(amino acids)=259AA_BP=
MCRVERVLPGPGPSATTMDRRKKPLDVTASSLVDLKAELFRKQEEFKQEKLLKDSGVFGKPKTTNKKPSIWSKQNVGVSNRAEKDAEQKI
EEQKTLDKAREKLEEKAKLYEKMTKGDFIDEEVEDMYLVDFTQKIIDKRKEMEASGAHRDSQKAGERDDDEENLPEGEIPPPQDPSEEWV

--------------------------------------------------------------
>13719_13719_2_CCDC174-ECHDC1_CCDC174_chr3_14708454_ENST00000383794_ECHDC1_chr6_127611422_ENST00000454859_length(transcript)=2365nt_BP=797nt
GACGGAGGTAGGCTTACGAGGCCTGTGTCGGGTAGAAAGGGTCCTTCCTGGACCGGGACCCTCTGCCACGACCATGGACCGTAGGAAAAA
GCCTTTGGACGTCACGGCCTCCTCGTTGGTAGATCTTAAGGCTGAACTCTTCCGAAAGCAAGAAGAATTCAAACAAGAAAAACTTCTAAA
AGATTCTGGAGTTTTTGGAAAACCAAAAACAACTAACAAGAAACCAAGTATCTGGAGCAAACAGAATGTAGGCGTTTCAAATCGAGCTGA
GAAGGATGCTGAACAGAAGATTGAAGAACAGAAGACTTTAGACAAAGCAAGGGAAAAATTGGAAGAAAAAGCCAAATTATATGAAAAAAT
GACTAAAGGAGACTTTATAGATGAAGAAGTAGAGGATATGTACCTTGTGGATTTCACACAGAAGATCATAGACAAGCGCAAAGAAATGGA
GGCATCTGGTGCCCATAGAGATTCTCAAAAGGCAGGAGAAAGGGACGACGATGAGGAAAACCTTCCTGAGGGAGAGATCCCTCCTCCCCA
AGACCCCAGTGAAGAATGGGTGGATTACGTGGACTCTTTGGGGCGTTCCCGGCGCTGTATGAGAAAGGATTTGCCAGATCTGCTGGAGAT
GGATAAAAATCTTCAGGGGAGACTTTTTATTAGTCCTGCTAATGAAAAAACCCTATTATCTGAAGATATGAGAAAAGAACTTCAGCGCCA
GCAATGGGAGGAAGAAGAAAGAGAGGCCCTGAAGAGGCCCATGGGGCCCGTACATTATGAAGACATTCGGGAAAATGGTTAATGACTCCA
GAGAGTAAGATCAGATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGA
CAAGCTCTCAAAGTGTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCA
GATGAAACTAAATCTCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCT
GTTTGTTCAGGCAGAGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTA
GAGGCTATTGCTAAGAAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATA
AATGTTAAATGATATTAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGA
ACTCATTTACCTCATTTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAA
AAATTATTGCTGTCAATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCT
GGCGTTACTTTTCATACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGG
GAGGTATCAGGGAACAAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGC
CCTTCATTTAAAAAAAGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCT
ACTAAACAGTGGTAGCCATGACATGGAAAGTCAACTGATTCTACAATTGGACATTCATTTGTGTGCCCTGGAATTTCCAACTAGTAATAA
ACAACTACTGTTGATGTAGTTTTAAACCACTTGAAGGGACTCATGAAGCATCCTGCAACATAAATTTGCATTTTTACATCAGATTTCTTT
TTTTTCCTGAAAAACAACTAACCTTCTAACAACTATCTTTCAAAAGTAAATGTAATAAAAATGCACAACATAAAATGTTTATGATCCCAG
CAATACACTTTTTAAAAAATGTGAAAGTCAAAGAATTAAGTTCTAGTTCTGACTCATCACAAGAGGTCAAAAGTATTTGCTACTGTAACA
TTCAATTCACATTTGAGAATCATGGTAAAAATAACTTGCATTTGCCTTACCATCATGATCCTACTGTTGAGTTAGGAAAATATGGTTAGA
CAGACTCACATTACTTTTTTTCAGAGGTAAACTCTAGATTACTGTGTCAACCCAATACTATTTGGCCATAGATGTAAAAACTACCAAATA

>13719_13719_2_CCDC174-ECHDC1_CCDC174_chr3_14708454_ENST00000383794_ECHDC1_chr6_127611422_ENST00000454859_length(amino acids)=259AA_BP=
MCRVERVLPGPGPSATTMDRRKKPLDVTASSLVDLKAELFRKQEEFKQEKLLKDSGVFGKPKTTNKKPSIWSKQNVGVSNRAEKDAEQKI
EEQKTLDKAREKLEEKAKLYEKMTKGDFIDEEVEDMYLVDFTQKIIDKRKEMEASGAHRDSQKAGERDDDEENLPEGEIPPPQDPSEEWV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCDC174-ECHDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCDC174-ECHDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCDC174-ECHDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource