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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CCDC24-ST3GAL3 (FusionGDB2 ID:13759)

Fusion Gene Summary for CCDC24-ST3GAL3

Fusion gene summary

Fusion gene information	Fusion gene name: CCDC24-ST3GAL3
	Fusion gene ID: 13759
		Hgene	Tgene
	Gene symbol	CCDC24	ST3GAL3
	Gene ID	149473	6487
	Gene name	coiled-coil domain containing 24	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
	Synonyms	-	EIEE15\|MRT12\|SIAT6\|ST3GALII\|ST3Gal III\|ST3GalIII\|ST3N
	Cytomap	1p34.1	1p34.1
	Type of gene	protein-coding	protein-coding
	Description	coiled-coil domain-containing protein 24	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferaseGal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferasealpha 2,3-ST 3alpha 2,3-sialyltransferase IIIalpha-2,3-sialyltransferase IIsialyltransferase 6 (N-acetyllacosaminide alpha 2,3-si
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000479055, ENST00000372318,	ENST00000262915, ENST00000351035, ENST00000372375, ENST00000330208, ENST00000332628, ENST00000335430, ENST00000347631, ENST00000353126, ENST00000361392, ENST00000361400, ENST00000361746, ENST00000361812, ENST00000372362, ENST00000372365, ENST00000372366, ENST00000372367, ENST00000372368, ENST00000372369, ENST00000372372, ENST00000372374, ENST00000372377, ENST00000461375, ENST00000528371, ENST00000531451, ENST00000531816, ENST00000531993, ENST00000533933, ENST00000545417,
Fusion gene scores	* DoF score	1 X 2 X 1=2	13 X 15 X 10=1950
	# samples	1	15
	** MAII score	log2(1/2*10)=2.32192809488736	log2(15/1950*10)=-3.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CCDC24 [Title/Abstract] AND ST3GAL3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CCDC24(44459636)-ST3GAL3(44290403), # samples:1 CCDC24(44457676)-ST3GAL3(44201904), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CCDC24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ST3GAL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-ZJ-AAXN-01A	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
ChimerDB4	CESC	TCGA-ZJ-AAXN-01A	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+

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Fusion Gene ORF analysis for CCDC24-ST3GAL3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000479055	ENST00000262915	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-3CDS	ENST00000479055	ENST00000351035	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-3CDS	ENST00000479055	ENST00000372375	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000330208	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000332628	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000335430	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000347631	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000353126	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000361392	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000361400	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000361746	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000361812	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000372362	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000372365	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000372366	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000372367	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000372368	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000372369	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000372372	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000372374	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000372377	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000461375	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000528371	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000531451	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000531816	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000531993	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000533933	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
3UTR-intron	ENST00000479055	ENST00000545417	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-5UTR	ENST00000372318	ENST00000262915	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-5UTR	ENST00000372318	ENST00000330208	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-5UTR	ENST00000372318	ENST00000335430	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-5UTR	ENST00000372318	ENST00000347631	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-5UTR	ENST00000372318	ENST00000351035	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-5UTR	ENST00000372318	ENST00000353126	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-5UTR	ENST00000372318	ENST00000361392	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-5UTR	ENST00000372318	ENST00000361400	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-5UTR	ENST00000372318	ENST00000372374	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-5UTR	ENST00000372318	ENST00000372375	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-5UTR	ENST00000372318	ENST00000372377	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-5UTR	ENST00000372318	ENST00000545417	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000330208	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000332628	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000332628	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000335430	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000347631	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000353126	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000361392	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000361400	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000361746	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000361746	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000361812	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000361812	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000372362	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000372362	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000372365	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000372365	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000372366	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000372366	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000372367	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000372367	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000372368	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000372368	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000372369	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000372369	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000372372	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000372372	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000372374	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000372377	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000461375	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000461375	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000528371	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000528371	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000531451	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000531451	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000531816	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000531816	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000531993	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000531993	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000533933	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
5CDS-intron	ENST00000372318	ENST00000533933	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
5CDS-intron	ENST00000372318	ENST00000545417	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
In-frame	ENST00000372318	ENST00000262915	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
In-frame	ENST00000372318	ENST00000351035	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
In-frame	ENST00000372318	ENST00000372375	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+
intron-5UTR	ENST00000479055	ENST00000262915	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-5UTR	ENST00000479055	ENST00000330208	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-5UTR	ENST00000479055	ENST00000335430	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-5UTR	ENST00000479055	ENST00000347631	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-5UTR	ENST00000479055	ENST00000351035	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-5UTR	ENST00000479055	ENST00000353126	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-5UTR	ENST00000479055	ENST00000361392	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-5UTR	ENST00000479055	ENST00000361400	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-5UTR	ENST00000479055	ENST00000372374	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-5UTR	ENST00000479055	ENST00000372375	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-5UTR	ENST00000479055	ENST00000372377	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-5UTR	ENST00000479055	ENST00000545417	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000332628	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000361746	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000361812	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000372362	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000372365	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000372366	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000372367	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000372368	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000372369	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000372372	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000461375	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000528371	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000531451	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000531816	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000531993	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+
intron-intron	ENST00000479055	ENST00000533933	CCDC24	chr1	44457676	-	ST3GAL3	chr1	44201904	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000372318

CCDC24

chr1

44459636

ENST00000262915

ST3GAL3

chr1

44290403

2686

668

1748

579

ENST00000372318

CCDC24

chr1

44459636

ENST00000372375

ST3GAL3

chr1

44290403

2686

668

1748

579

ENST00000372318

CCDC24

chr1

44459636

ENST00000351035

ST3GAL3

chr1

44290403

2686

668

1748

579

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372318	ENST00000262915	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+	0.024203327	0.9757967
ENST00000372318	ENST00000372375	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+	0.024203327	0.9757967
ENST00000372318	ENST00000351035	CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290403	+	0.024203327	0.9757967

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Fusion Genomic Features for CCDC24-ST3GAL3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290402	+	5.13E-05	0.99994874
CCDC24	chr1	44459636	+	ST3GAL3	chr1	44290402	+	5.13E-05	0.99994874

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCDC24-ST3GAL3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:44459636/chr1:44290403)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000330208

1_8

156.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000330208

29_375

156.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000332628

1_8

345.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000332628

29_375

345.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000335430

1_8

522.3333333333334

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000335430

29_375

522.3333333333334

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000347631

1_8

391.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000347631

29_375

391.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000353126

1_8

278.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000353126

29_375

278.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361392

1_8

376.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361392

29_375

376.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361400

1_8

360.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361400

29_375

360.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361812

1_8

171.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361812

29_375

171.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372362

1_8

156.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372362

29_375

156.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372365

1_8

177.66666666666666

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372365

29_375

177.66666666666666

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372366

1_8

161.66666666666666

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372366

29_375

161.66666666666666

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372367

1_8

202.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372367

29_375

202.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372369

1_8

346.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372369

29_375

346.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372374

1_8

345.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372374

29_375

345.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372377

1_8

445.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372377

29_375

445.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000528371

1_8

187.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000528371

29_375

187.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000531451

1_8

140.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000531451

29_375

140.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000531816

1_8

102.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000531816

29_375

102.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000531993

1_8

262.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000531993

29_375

262.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000533933

1_8

278.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000533933

29_375

278.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000545417

1_8

171.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000545417

29_375

171.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000330208

9_28

156.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000332628

9_28

345.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000335430

9_28

522.3333333333334

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000347631

9_28

391.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000353126

9_28

278.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361392

9_28

376.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361400

9_28

360.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361812

9_28

171.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372362

9_28

156.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372365

9_28

177.66666666666666

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372366

9_28

161.66666666666666

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372367

9_28

202.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372369

9_28

346.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372374

9_28

345.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372377

9_28

445.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000528371

9_28

187.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000531451

9_28

140.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000531816

9_28

102.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000531993

9_28

262.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000533933

9_28

278.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000545417

9_28

171.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CCDC24

chr1:44459636

chr1:44290403

ENST00000372318

168_225

165

308.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000262915

1_8

445.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000262915

29_375

445.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000351035

1_8

414.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000351035

29_375

414.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361746

1_8

445.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361746

29_375

445.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372368

1_8

430.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372368

29_375

430.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372372

1_8

414.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372372

29_375

414.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372375

1_8

430.0

Topological domain

Cytoplasmic

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372375

29_375

430.0

Topological domain

Lumenal

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000262915

9_28

445.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000351035

9_28

414.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000361746

9_28

445.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372368

9_28

430.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372372

9_28

414.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST3GAL3

chr1:44459636

chr1:44290403

ENST00000372375

9_28

430.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Top

Fusion Gene Sequence for CCDC24-ST3GAL3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>13759_13759_1_CCDC24-ST3GAL3_CCDC24_chr1_44459636_ENST00000372318_ST3GAL3_chr1_44290403_ENST00000262915_length(transcript)=2686nt_BP=668nt
GCTAGGGCCCTGGTTCCCACTGCCTGGTTTCTGGGCCCCCGGCATCCGAGTCGGCCAAAAGCCGGGCAGAAGAGAGCGCCAAGGACTGGC
AGTTCCGGAACGGGCAATCCCAGCCGAGGGGACCAGCGGCAGAGCACGGGTCCGAGCCGGGGACGGCGGCGTCGGTGGGTCATGCTCCGG
CACTCCCCCTCGCTGTGGGAGCTGGTGGAGGAGCACGTTCCGCTCCGGGAGCGACGCGAAGTGAAGAGGATTCTGGGGGAGGCGGCGGTG
GACCTGAGCCTGGAGCTGCGGGCGGAGGTGGCGATGTTACGGGCACTGCTCCAAGAGGCTCGATCCTCTCAAGCCCCCAGCTCCCGCCCC
ATCTCTGACCCCTCTTCTCTTCTGGCACCACCGCCTCTCCTAAAGGACCTCTTGCGCCAGGAGCTCCGGCAGTTGCTCCAGGGTCTCCGC
CACAAAGCCATCTGTGAGGGCAGGGACCAGGCCCAAGCTTGGGTCCAGTATAGCCCCAGGGTCCTGCACTTTGCCTTGGAGGAGCCCAGG
TGTGATTTGCCAGAACAGGAGATATTCCAGATGAGAGGTGGTGGGCCCAGCAGCGGTCACAGAGATCTCAGCATCATCAAGGACCAACTG
AACGTGTCCAACATTGACCAGGTGGCCAGACACCTGAGCTCACCGAGGACTCTCTGCACGGTGGTTTTTGGCCTTGACTGCATATTGGAA
TCACCTGGAGAGCCTAAAAAATTACTGATGCCTGCATCCCACCCTCTAGAGATTTTGAAGTCACTGAGCGAGGACACAGCCTTTGCATTA
GGATTTTTAAAGCTGCCCAGGCCTGCTGAATTAGCCACCAAGTACGCAAACTTTTCAGAGGGAGCTTGCAAGCCTGGCTATGCTTCAGCC
TTGATGACGGCCATCTTCCCCCGGTTCTCCAAGCCAGCACCCATGTTCCTGGATGACTCCTTTCGCAAGTGGGCTAGAATCCGGGAGTTC
GTGCCGCCTTTTGGGATCAAAGGTCAAGACAATCTGATCAAAGCCATCTTGTCAGTCACCAAAGAGTACCGCCTGACCCCTGCCTTGGAC
AGCCTCCGCTGCCGCCGCTGCATCATCGTGGGCAATGGAGGCGTTCTTGCCAACAAGTCTCTGGGGTCACGAATTGACGACTATGACATT
GTGGTGAGACTGAATTCAGCACCAGTGAAAGGCTTTGAGAAGGACGTGGGCAGCAAAACGACACTGCGCATCACCTACCCCGAGGGCGCC
ATGCAGCGGCCTGAGCAGTACGAGCGCGATTCTCTCTTTGTCCTCGCCGGCTTCAAGTGGCAGGACTTTAAGTGGTTGAAATACATCGTC
TACAAGGAGAGAGTGAGTGCATCGGATGGCTTCTGGAAATCTGTGGCCACTCGAGTGCCCAAGGAGCCCCCTGAGATTCGAATCCTCAAC
CCATATTTCATCCAGGAGGCCGCCTTCACCCTCATTGGCCTGCCCTTCAACAATGGCCTCATGGGCCGGGGGAACATCCCTACCCTTGGC
AGTGTGGCAGTGACCATGGCACTACACGGCTGTGACGAGGTGGCAGTCGCAGGATTTGGCTATGACATGAGCACACCCAACGCACCCCTG
CACTACTATGAGACCGTTCGCATGGCAGCCATCAAAGAGTCCTGGACGCACAATATCCAGCGAGAGAAAGAGTTTCTGCGGAAGCTGGTG
AAAGCTCGCGTCATCACTGATCTAAGCAGTGGCATCTGAGTGGGCCCAGCACATGGCCATAGAGGCCCAGGCACCACCAGGAGCAGCAGC
CAGCACCACCTACACAGGAGTCTTCAGACCCAGAGAAGGACGGTGCCAAGGGCCCCAGGGGCAGCAAGGCCTTGGTGGAGCAGCCAGAGC
TGTGCCTGCTCAGCAGCCAGTCTCAGAGACCAGCACTCAGCCTCATTCAGCATGGGTCCTTGATGCCAGAGGGCCAGCAGGCTCCTGGCT
GTGCCCAGCAGGCCCAGCATGCAGGTGGTGGGACACTGGGCAGCAAGGCTGCTGCCGGAATCACTTCTCCAATCAGTGTTTGGTGTATTA
TCATTTTGTGAATTTGGGTAGGGGGGAGGGTAGGGATAATTTATTTTTAAATAAGGTTGGAGATGTCAAGTTGGGTTCACTTGCCATGCA
GGAAGAGGCCCACTAGAGGGCCCATCAGGCAGTGTTACCTGTTAGCTCCCTGTGGGGCAGGAGTGCCAGGACCAGCCTGTACCTTGCTGT
GGGGCTACAGGATGGTGGGCAGGATCTCAAGCCAGCCCCCTCCAGCTCATGACACTGTTTGGCCTTTCTTGGGGAGAAGGCGGGGTATTC
CCACTCACCAGCCCTAGCTGTCCCATGGGGAAACCCTGGAGCCATCCCTTCGGAGCCAACAAGACCGCCCCAGGGCTATAGCAGAAAGAA
CTTTAAAGCTCAGGAGGGTGACGCCCAGCTCCGCCTGCTGGGAAGAGCTCCCCTCCACAGCTGCAGCTGATCCATAGGACTACCGCAGGC
CCGGACTCACCAACTTGCCACATGTTCTAGGTTTCAGCAACAAGACTGCCAGGTGGTTGGGTTCTGCCTTTAGCCTGGACCAAAGGGAAG

>13759_13759_1_CCDC24-ST3GAL3_CCDC24_chr1_44459636_ENST00000372318_ST3GAL3_chr1_44290403_ENST00000262915_length(amino acids)=579AA_BP=219
MVPTAWFLGPRHPSRPKAGQKRAPRTGSSGTGNPSRGDQRQSTGPSRGRRRRWVMLRHSPSLWELVEEHVPLRERREVKRILGEAAVDLS
LELRAEVAMLRALLQEARSSQAPSSRPISDPSSLLAPPPLLKDLLRQELRQLLQGLRHKAICEGRDQAQAWVQYSPRVLHFALEEPRCDL
PEQEIFQMRGGGPSSGHRDLSIIKDQLNVSNIDQVARHLSSPRTLCTVVFGLDCILESPGEPKKLLMPASHPLEILKSLSEDTAFALGFL
KLPRPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLR
CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKE
RVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYY

--------------------------------------------------------------
>13759_13759_2_CCDC24-ST3GAL3_CCDC24_chr1_44459636_ENST00000372318_ST3GAL3_chr1_44290403_ENST00000351035_length(transcript)=2686nt_BP=668nt
GCTAGGGCCCTGGTTCCCACTGCCTGGTTTCTGGGCCCCCGGCATCCGAGTCGGCCAAAAGCCGGGCAGAAGAGAGCGCCAAGGACTGGC
AGTTCCGGAACGGGCAATCCCAGCCGAGGGGACCAGCGGCAGAGCACGGGTCCGAGCCGGGGACGGCGGCGTCGGTGGGTCATGCTCCGG
CACTCCCCCTCGCTGTGGGAGCTGGTGGAGGAGCACGTTCCGCTCCGGGAGCGACGCGAAGTGAAGAGGATTCTGGGGGAGGCGGCGGTG
GACCTGAGCCTGGAGCTGCGGGCGGAGGTGGCGATGTTACGGGCACTGCTCCAAGAGGCTCGATCCTCTCAAGCCCCCAGCTCCCGCCCC
ATCTCTGACCCCTCTTCTCTTCTGGCACCACCGCCTCTCCTAAAGGACCTCTTGCGCCAGGAGCTCCGGCAGTTGCTCCAGGGTCTCCGC
CACAAAGCCATCTGTGAGGGCAGGGACCAGGCCCAAGCTTGGGTCCAGTATAGCCCCAGGGTCCTGCACTTTGCCTTGGAGGAGCCCAGG
TGTGATTTGCCAGAACAGGAGATATTCCAGATGAGAGGTGGTGGGCCCAGCAGCGGTCACAGAGATCTCAGCATCATCAAGGACCAACTG
AACGTGTCCAACATTGACCAGGTGGCCAGACACCTGAGCTCACCGAGGACTCTCTGCACGGTGGTTTTTGGCCTTGACTGCATATTGGAA
TCACCTGGAGAGCCTAAAAAATTACTGATGCCTGCATCCCACCCTCTAGAGATTTTGAAGTCACTGAGCGAGGACACAGCCTTTGCATTA
GGATTTTTAAAGCTGCCCAGGCCTGCTGAATTAGCCACCAAGTACGCAAACTTTTCAGAGGGAGCTTGCAAGCCTGGCTATGCTTCAGCC
TTGATGACGGCCATCTTCCCCCGGTTCTCCAAGCCAGCACCCATGTTCCTGGATGACTCCTTTCGCAAGTGGGCTAGAATCCGGGAGTTC
GTGCCGCCTTTTGGGATCAAAGGTCAAGACAATCTGATCAAAGCCATCTTGTCAGTCACCAAAGAGTACCGCCTGACCCCTGCCTTGGAC
AGCCTCCGCTGCCGCCGCTGCATCATCGTGGGCAATGGAGGCGTTCTTGCCAACAAGTCTCTGGGGTCACGAATTGACGACTATGACATT
GTGGTGAGACTGAATTCAGCACCAGTGAAAGGCTTTGAGAAGGACGTGGGCAGCAAAACGACACTGCGCATCACCTACCCCGAGGGCGCC
ATGCAGCGGCCTGAGCAGTACGAGCGCGATTCTCTCTTTGTCCTCGCCGGCTTCAAGTGGCAGGACTTTAAGTGGTTGAAATACATCGTC
TACAAGGAGAGAGTGAGTGCATCGGATGGCTTCTGGAAATCTGTGGCCACTCGAGTGCCCAAGGAGCCCCCTGAGATTCGAATCCTCAAC
CCATATTTCATCCAGGAGGCCGCCTTCACCCTCATTGGCCTGCCCTTCAACAATGGCCTCATGGGCCGGGGGAACATCCCTACCCTTGGC
AGTGTGGCAGTGACCATGGCACTACACGGCTGTGACGAGGTGGCAGTCGCAGGATTTGGCTATGACATGAGCACACCCAACGCACCCCTG
CACTACTATGAGACCGTTCGCATGGCAGCCATCAAAGAGTCCTGGACGCACAATATCCAGCGAGAGAAAGAGTTTCTGCGGAAGCTGGTG
AAAGCTCGCGTCATCACTGATCTAAGCAGTGGCATCTGAGTGGGCCCAGCACATGGCCATAGAGGCCCAGGCACCACCAGGAGCAGCAGC
CAGCACCACCTACACAGGAGTCTTCAGACCCAGAGAAGGACGGTGCCAAGGGCCCCAGGGGCAGCAAGGCCTTGGTGGAGCAGCCAGAGC
TGTGCCTGCTCAGCAGCCAGTCTCAGAGACCAGCACTCAGCCTCATTCAGCATGGGTCCTTGATGCCAGAGGGCCAGCAGGCTCCTGGCT
GTGCCCAGCAGGCCCAGCATGCAGGTGGTGGGACACTGGGCAGCAAGGCTGCTGCCGGAATCACTTCTCCAATCAGTGTTTGGTGTATTA
TCATTTTGTGAATTTGGGTAGGGGGGAGGGTAGGGATAATTTATTTTTAAATAAGGTTGGAGATGTCAAGTTGGGTTCACTTGCCATGCA
GGAAGAGGCCCACTAGAGGGCCCATCAGGCAGTGTTACCTGTTAGCTCCCTGTGGGGCAGGAGTGCCAGGACCAGCCTGTACCTTGCTGT
GGGGCTACAGGATGGTGGGCAGGATCTCAAGCCAGCCCCCTCCAGCTCATGACACTGTTTGGCCTTTCTTGGGGAGAAGGCGGGGTATTC
CCACTCACCAGCCCTAGCTGTCCCATGGGGAAACCCTGGAGCCATCCCTTCGGAGCCAACAAGACCGCCCCAGGGCTATAGCAGAAAGAA
CTTTAAAGCTCAGGAGGGTGACGCCCAGCTCCGCCTGCTGGGAAGAGCTCCCCTCCACAGCTGCAGCTGATCCATAGGACTACCGCAGGC
CCGGACTCACCAACTTGCCACATGTTCTAGGTTTCAGCAACAAGACTGCCAGGTGGTTGGGTTCTGCCTTTAGCCTGGACCAAAGGGAAG

>13759_13759_2_CCDC24-ST3GAL3_CCDC24_chr1_44459636_ENST00000372318_ST3GAL3_chr1_44290403_ENST00000351035_length(amino acids)=579AA_BP=219
MVPTAWFLGPRHPSRPKAGQKRAPRTGSSGTGNPSRGDQRQSTGPSRGRRRRWVMLRHSPSLWELVEEHVPLRERREVKRILGEAAVDLS
LELRAEVAMLRALLQEARSSQAPSSRPISDPSSLLAPPPLLKDLLRQELRQLLQGLRHKAICEGRDQAQAWVQYSPRVLHFALEEPRCDL
PEQEIFQMRGGGPSSGHRDLSIIKDQLNVSNIDQVARHLSSPRTLCTVVFGLDCILESPGEPKKLLMPASHPLEILKSLSEDTAFALGFL
KLPRPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLR
CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKE
RVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYY

--------------------------------------------------------------
>13759_13759_3_CCDC24-ST3GAL3_CCDC24_chr1_44459636_ENST00000372318_ST3GAL3_chr1_44290403_ENST00000372375_length(transcript)=2686nt_BP=668nt
GCTAGGGCCCTGGTTCCCACTGCCTGGTTTCTGGGCCCCCGGCATCCGAGTCGGCCAAAAGCCGGGCAGAAGAGAGCGCCAAGGACTGGC
AGTTCCGGAACGGGCAATCCCAGCCGAGGGGACCAGCGGCAGAGCACGGGTCCGAGCCGGGGACGGCGGCGTCGGTGGGTCATGCTCCGG
CACTCCCCCTCGCTGTGGGAGCTGGTGGAGGAGCACGTTCCGCTCCGGGAGCGACGCGAAGTGAAGAGGATTCTGGGGGAGGCGGCGGTG
GACCTGAGCCTGGAGCTGCGGGCGGAGGTGGCGATGTTACGGGCACTGCTCCAAGAGGCTCGATCCTCTCAAGCCCCCAGCTCCCGCCCC
ATCTCTGACCCCTCTTCTCTTCTGGCACCACCGCCTCTCCTAAAGGACCTCTTGCGCCAGGAGCTCCGGCAGTTGCTCCAGGGTCTCCGC
CACAAAGCCATCTGTGAGGGCAGGGACCAGGCCCAAGCTTGGGTCCAGTATAGCCCCAGGGTCCTGCACTTTGCCTTGGAGGAGCCCAGG
TGTGATTTGCCAGAACAGGAGATATTCCAGATGAGAGGTGGTGGGCCCAGCAGCGGTCACAGAGATCTCAGCATCATCAAGGACCAACTG
AACGTGTCCAACATTGACCAGGTGGCCAGACACCTGAGCTCACCGAGGACTCTCTGCACGGTGGTTTTTGGCCTTGACTGCATATTGGAA
TCACCTGGAGAGCCTAAAAAATTACTGATGCCTGCATCCCACCCTCTAGAGATTTTGAAGTCACTGAGCGAGGACACAGCCTTTGCATTA
GGATTTTTAAAGCTGCCCAGGCCTGCTGAATTAGCCACCAAGTACGCAAACTTTTCAGAGGGAGCTTGCAAGCCTGGCTATGCTTCAGCC
TTGATGACGGCCATCTTCCCCCGGTTCTCCAAGCCAGCACCCATGTTCCTGGATGACTCCTTTCGCAAGTGGGCTAGAATCCGGGAGTTC
GTGCCGCCTTTTGGGATCAAAGGTCAAGACAATCTGATCAAAGCCATCTTGTCAGTCACCAAAGAGTACCGCCTGACCCCTGCCTTGGAC
AGCCTCCGCTGCCGCCGCTGCATCATCGTGGGCAATGGAGGCGTTCTTGCCAACAAGTCTCTGGGGTCACGAATTGACGACTATGACATT
GTGGTGAGACTGAATTCAGCACCAGTGAAAGGCTTTGAGAAGGACGTGGGCAGCAAAACGACACTGCGCATCACCTACCCCGAGGGCGCC
ATGCAGCGGCCTGAGCAGTACGAGCGCGATTCTCTCTTTGTCCTCGCCGGCTTCAAGTGGCAGGACTTTAAGTGGTTGAAATACATCGTC
TACAAGGAGAGAGTGAGTGCATCGGATGGCTTCTGGAAATCTGTGGCCACTCGAGTGCCCAAGGAGCCCCCTGAGATTCGAATCCTCAAC
CCATATTTCATCCAGGAGGCCGCCTTCACCCTCATTGGCCTGCCCTTCAACAATGGCCTCATGGGCCGGGGGAACATCCCTACCCTTGGC
AGTGTGGCAGTGACCATGGCACTACACGGCTGTGACGAGGTGGCAGTCGCAGGATTTGGCTATGACATGAGCACACCCAACGCACCCCTG
CACTACTATGAGACCGTTCGCATGGCAGCCATCAAAGAGTCCTGGACGCACAATATCCAGCGAGAGAAAGAGTTTCTGCGGAAGCTGGTG
AAAGCTCGCGTCATCACTGATCTAAGCAGTGGCATCTGAGTGGGCCCAGCACATGGCCATAGAGGCCCAGGCACCACCAGGAGCAGCAGC
CAGCACCACCTACACAGGAGTCTTCAGACCCAGAGAAGGACGGTGCCAAGGGCCCCAGGGGCAGCAAGGCCTTGGTGGAGCAGCCAGAGC
TGTGCCTGCTCAGCAGCCAGTCTCAGAGACCAGCACTCAGCCTCATTCAGCATGGGTCCTTGATGCCAGAGGGCCAGCAGGCTCCTGGCT
GTGCCCAGCAGGCCCAGCATGCAGGTGGTGGGACACTGGGCAGCAAGGCTGCTGCCGGAATCACTTCTCCAATCAGTGTTTGGTGTATTA
TCATTTTGTGAATTTGGGTAGGGGGGAGGGTAGGGATAATTTATTTTTAAATAAGGTTGGAGATGTCAAGTTGGGTTCACTTGCCATGCA
GGAAGAGGCCCACTAGAGGGCCCATCAGGCAGTGTTACCTGTTAGCTCCCTGTGGGGCAGGAGTGCCAGGACCAGCCTGTACCTTGCTGT
GGGGCTACAGGATGGTGGGCAGGATCTCAAGCCAGCCCCCTCCAGCTCATGACACTGTTTGGCCTTTCTTGGGGAGAAGGCGGGGTATTC
CCACTCACCAGCCCTAGCTGTCCCATGGGGAAACCCTGGAGCCATCCCTTCGGAGCCAACAAGACCGCCCCAGGGCTATAGCAGAAAGAA
CTTTAAAGCTCAGGAGGGTGACGCCCAGCTCCGCCTGCTGGGAAGAGCTCCCCTCCACAGCTGCAGCTGATCCATAGGACTACCGCAGGC
CCGGACTCACCAACTTGCCACATGTTCTAGGTTTCAGCAACAAGACTGCCAGGTGGTTGGGTTCTGCCTTTAGCCTGGACCAAAGGGAAG

>13759_13759_3_CCDC24-ST3GAL3_CCDC24_chr1_44459636_ENST00000372318_ST3GAL3_chr1_44290403_ENST00000372375_length(amino acids)=579AA_BP=219
MVPTAWFLGPRHPSRPKAGQKRAPRTGSSGTGNPSRGDQRQSTGPSRGRRRRWVMLRHSPSLWELVEEHVPLRERREVKRILGEAAVDLS
LELRAEVAMLRALLQEARSSQAPSSRPISDPSSLLAPPPLLKDLLRQELRQLLQGLRHKAICEGRDQAQAWVQYSPRVLHFALEEPRCDL
PEQEIFQMRGGGPSSGHRDLSIIKDQLNVSNIDQVARHLSSPRTLCTVVFGLDCILESPGEPKKLLMPASHPLEILKSLSEDTAFALGFL
KLPRPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLR
CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKE
RVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CCDC24-ST3GAL3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CCDC24-ST3GAL3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CCDC24-ST3GAL3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source