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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ACOX1-PRKCA (FusionGDB2 ID:1398) |
Fusion Gene Summary for ACOX1-PRKCA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACOX1-PRKCA | Fusion gene ID: 1398 | Hgene | Tgene | Gene symbol | ACOX1 | PRKCA | Gene ID | 51 | 5578 |
| Gene name | acyl-CoA oxidase 1 | protein kinase C alpha | |
| Synonyms | ACOX|PALMCOX|SCOX | AAG6|PKC-alpha|PKCA|PKCI+/-|PKCalpha|PRKACA | |
| Cytomap | 17q25.1 | 17q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | peroxisomal acyl-coenzyme A oxidase 1AOXacyl-CoA oxidase 1, palmitoylacyl-CoA oxidase, straight-chainacyl-Coenzyme A oxidase 1, palmitoylpalmitoyl-CoA oxidaseperoxisomal fatty acyl-CoA oxidasestraight-chain acyl-CoA oxidase | protein kinase C alpha typePKC-Aaging-associated gene 6 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q15067 | PICK1 | |
| Ensembl transtripts involved in fusion gene | ENST00000293217, ENST00000301608, ENST00000537812, ENST00000591857, | ENST00000583361, ENST00000413366, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 26 X 21 X 9=4914 |
| # samples | 10 | 29 | |
| ** MAII score | log2(10/180*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(29/4914*10)=-4.08277305234723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACOX1 [Title/Abstract] AND PRKCA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ACOX1(73974614)-PRKCA(64799990), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ACOX1-PRKCA seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ACOX1-PRKCA seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ACOX1-PRKCA seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. ACOX1-PRKCA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. ACOX1-PRKCA seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ACOX1-PRKCA seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACOX1 | GO:0006629 | lipid metabolic process | 8117268 |
| Tgene | PRKCA | GO:0006468 | protein phosphorylation | 10770950 |
| Tgene | PRKCA | GO:0035408 | histone H3-T6 phosphorylation | 20228790 |
| Tgene | PRKCA | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 20011604 |
| Tgene | PRKCA | GO:0090330 | regulation of platelet aggregation | 12724315 |
| Fusion gene breakpoints across ACOX1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PRKCA (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8286 | ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + |
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Fusion Gene ORF analysis for ACOX1-PRKCA |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000293217 | ENST00000583361 | ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + |
| 5CDS-intron | ENST00000301608 | ENST00000583361 | ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + |
| 5CDS-intron | ENST00000537812 | ENST00000583361 | ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + |
| 5UTR-3CDS | ENST00000591857 | ENST00000413366 | ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + |
| 5UTR-intron | ENST00000591857 | ENST00000583361 | ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + |
| Frame-shift | ENST00000537812 | ENST00000413366 | ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + |
| In-frame | ENST00000293217 | ENST00000413366 | ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + |
| In-frame | ENST00000301608 | ENST00000413366 | ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000293217 | ACOX1 | chr17 | 73974614 | - | ENST00000413366 | PRKCA | chr17 | 64799990 | + | 7430 | 559 | 3053 | 3616 | 187 |
| ENST00000301608 | ACOX1 | chr17 | 73974614 | - | ENST00000413366 | PRKCA | chr17 | 64799990 | + | 7201 | 330 | 2824 | 3387 | 187 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000293217 | ENST00000413366 | ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + | 0.22776093 | 0.7722391 |
| ENST00000301608 | ENST00000413366 | ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + | 0.22236322 | 0.77763677 |
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Fusion Genomic Features for ACOX1-PRKCA |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + | 2.32E-08 | 1 |
| ACOX1 | chr17 | 73974614 | - | PRKCA | chr17 | 64799990 | + | 2.32E-08 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ACOX1-PRKCA |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73974614/chr17:64799990) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACOX1 | PRKCA |
| FUNCTION: Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway. {ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:17458872, ECO:0000269|PubMed:17603022, ECO:0000269|PubMed:32169171}.; FUNCTION: [Isoform 1]: Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. {ECO:0000269|PubMed:17603022}.; FUNCTION: [Isoform 2]: Is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA. {ECO:0000269|PubMed:17603022}. | 415 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACOX1 | chr17:73974614 | chr17:64799990 | ENST00000293217 | - | 2 | 14 | 658_660 | 89 | 661.0 | Motif | Note=Microbody targeting signal |
| Hgene | ACOX1 | chr17:73974614 | chr17:64799990 | ENST00000301608 | - | 2 | 14 | 658_660 | 89 | 661.0 | Motif | Note=Microbody targeting signal |
| Hgene | ACOX1 | chr17:73974614 | chr17:64799990 | ENST00000537812 | - | 2 | 14 | 658_660 | 51 | 623.0 | Motif | Note=Microbody targeting signal |
| Tgene | PRKCA | chr17:73974614 | chr17:64799990 | ENST00000413366 | 15 | 17 | 158_275 | 618 | 673.0 | Domain | C2 | |
| Tgene | PRKCA | chr17:73974614 | chr17:64799990 | ENST00000413366 | 15 | 17 | 339_597 | 618 | 673.0 | Domain | Protein kinase | |
| Tgene | PRKCA | chr17:73974614 | chr17:64799990 | ENST00000413366 | 15 | 17 | 598_668 | 618 | 673.0 | Domain | AGC-kinase C-terminal | |
| Tgene | PRKCA | chr17:73974614 | chr17:64799990 | ENST00000413366 | 15 | 17 | 345_353 | 618 | 673.0 | Nucleotide binding | ATP | |
| Tgene | PRKCA | chr17:73974614 | chr17:64799990 | ENST00000413366 | 15 | 17 | 101_151 | 618 | 673.0 | Zinc finger | Phorbol-ester/DAG-type 2 | |
| Tgene | PRKCA | chr17:73974614 | chr17:64799990 | ENST00000413366 | 15 | 17 | 36_86 | 618 | 673.0 | Zinc finger | Phorbol-ester/DAG-type 1 |
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Fusion Gene Sequence for ACOX1-PRKCA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >1398_1398_1_ACOX1-PRKCA_ACOX1_chr17_73974614_ENST00000293217_PRKCA_chr17_64799990_ENST00000413366_length(transcript)=7430nt_BP=559nt CGAGGATCCGCTCGGGAGCCTCCCCTGGCCAGGAGCAGGGGATTAGTCTGCCCCGCGACCGGCCCCAGCCACGACGCGGACATCGCCCCC TCTGTCTGGGCCGCTGTCACTCACGCGCCAAAGGGCCACGGAGAAAGAAGGGGCGGGCCGGGGCGGGCCGGGCGAGCGGAGGCGGGGACT TGCGCCGTCCTGAGGCTGCCTCCTAGGGTCCGGCCGGCGCTGGAGCTGCGGATTTAGATTGTCACTGCCACCTCGGTCGGTGCTTACTTC GCTGCCAGCTGGTCGTCGCCATGAACCCGGACCTGCGCAGGGAGCGGGATTCCGCCAGCTTCAACCCGGAGCTGCTTACACACATCCTGG ACGGCAGCCCCGAGAAAACCCGGCGCCGCCGAGAGATCGAGAACATGATCCTGAACGACCCAGACTTCCAGCATGAGGACTTGAACTTCC TCACTCGCAGCCAGCGTTATGAGGTGGCTGTCAGGAAAAGTGCCATCATGGTGAAGAAGATGAGGGAGTTTGGCATCGCTGACCCTGATG AAATTATGTGGTTTAAAAATGTGGCAAAGGAGCAGAGAACTTTGACAAGTTCTTCACACGAGGACAGCCCGTCTTAACACCACCTGATCA GCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCTCGTATGTCAACCCCCAGTTTGTGCACCCCATCTTACAGAGTGCAGT ATGAAACTCACCAGCGAGAACAAACACCTCCCCAGCCCCCAGCCCTCCCCGCAGTGGGAAGTGAATCCTTAACCCTAAAATTTTAAGGCC ACGGCCTTGTGTCTGATTCCATATGGAGGCCTGAAAATTGTAGGGTTATTAGTCCAAATGTGATCAACTGTTCAGGGTCTCTCTCTTACA ACCAAGAACATTATCTTAGTGGAAGATGGTACGTCATGCTCAGTGTCCAGTTTAATTCTGTAGAAGTTACGTCTGGCTCTAGGTTAACCC TTCCTAGAAAGCAAGCAGACTGTTGCCCCATTTTGGGTACAATTTGATATACTTTCCATACCCTCCATCTGTGGATTTTTCAGCATTGGA ATCCCCCAACCAGAGATGTTAAAGTGAGCCTGTCCCAGGAAACATCTCCACCCAAGACGTCTTTGGAATCCAAGAACAGGAAGCCAAGAG AGTGAGCAGGGAGGGATTGGGGGTGGGGGAGGCCTCAAAATACCGACTGCGTCCATTCTCTGCCTCCATGGAAACAGCCCCTAGAATCTG AAAGGCCGGGATAAACCTAATCACTGTTCCCAAACATTGACAAATCCTAACCCAACCATGGTCCAGCAGTTACCAGTTTAAACAAAAAAA CCTCAGATGAGTGTTGGGTGAATCTGTCATCTGGTACCCTCCTTGGTTGATAACTGTCTTGATACTTTTCATTCTTTGTAAGAGGCCAAA TCGTCTAAGGACGTTGCTGAACAAGCGTGTGAAATCATTTCAGATCAAGGATAAGCCAGTGTGTACATATGTTCATTTTAATCTCTGGGA GATTATTTTTCCATCCAGGGTGCCATCAGTAATCATGCCACTACTCACCAGTGTTGTTCACCAACACCCACCCCCACACACACCAACATT TTGCTGCCTACCTTGTTATCCTTCTCAAGAAGCTGAAGTGTACGCCCTCTCCCCTTTTGTGCTTATTTATTTAATAGGCTGCAGTGTCGC TTATGAAAGTACGATGTACAGTAACTTAATGGAAGTGCTGACTCTAGCATCAGCCTCTACCGATTGATTTTCCTCCCTTCTCTAGCCCTG GATGTCCACTTAGGGATAAAAAGAATATGGTTTTGGTTCCCATTTCTAGTTCACGTTGAATGACAGGCCTGGAGCTGTAGAATCAGGAAA CCCGGATGCCTAACAGCTCAAAGATGTTTTGTTAATAGAAGGATTTTAATACGTTTTGCAAATGCATCATGCAATGAATTTTGCATGTTT ATAATAAACCTTAATAACAAGTGAATCTATATTATTGATATAATCGTATCAAGTATAAAGAGAGTATTATAATAATTTTATAAGACACAA TTGTGCTCTATTTGTGCAGGTTCTTGTTTCTAATCCTCTTTTCTAATTAAGTTTTAGCTGAATCCCTTGCTTCTGTGCTTTCCCTCCCTG CACATGGGCACTGTATCAGATAGATTACTTTTTAAATGTAGATAAAATTTCAAAAATGAATGGCTAGTTTACGTGATAGATTAGGCTCTT ACTACATATGTGTGTGTATATATATGTATTTGATTCTACCTGCAAACAAATTTTTATTGGTGAGGACTATTTTTGAGCTGACACTCCCTC TTAGTTTCTTCATGTCACCTTTCGTCCTGGTTCCTCCGCCACTCTTCCTCTTGGGGACAACAGGAAGTGTCTGATTCCAGTCTGCCTAGT ACGTTGGTACACACGTGGCATTGCCGCAGCACCTGGGCTGACCTTTGTGTGTGCGTGTGTGTGTGTTTCCTTCTTCCCTTCAGCCTGTGA CTGTTGCTGACTCCAGGGGTGGGAGGGATGGGGAGACTCCCCTCTTGCTGTGTGTACTGGACACGCAGGAAGCATGCTGTCTTGCTGCCT CTGCAACGACCTGTCGTTTGCTCCAGCATGCACAAACTTCGTGAGACCAACACAGCCGTGCCCTGCAGGCACCAGCACGTGCTTTTCAGA GGCTGCGGACTTTCTTCCAGCCATTGTGGCATTGGCCTTTCCAGTCTTGGGAGGAGCGCGCTGCTTTGGTGAGACACCCCCATGCAAGGT CCTCAGAGTAGCCGGGTTCTACCACAAACAGAAACAGAATGAAAGTAGCTGTCAGTCCTTGTAGAGAGCCGCTCTGTTTCCTCCCAGAAG CATCTCCCAGCTAAGCTCGCATTATTTTTCTCCTCTGGCTGTTTGCCTGAAGTTCACAGAACACACAACCATGAAAGGCTTTTTGAGGTG AGAGGCCCAGGTGGTCCTGGCAACCCTGAGTAGAAGGAGAGACGGGGTAGGGAACGGGCCCGGCCAGAAAAGAACCATTTCTTCTGCCAT CTTTTATGCACCATAGACATCGAGACTCCAGGGGGTCCTGGCTCCCCTGTCCCTGCAGCCCTGCAGGTCAGTGCATGATCTGGGTTCGTG TCCTGACCAGGTGCTCCTCCTTTGATCCGAGGGGAAAGGGACTGGTTTATAGAAAGAGCCTAGGAGACAAAAGGGCCAGTCCCCCTGCCC AGAATGGAGCAGCAGCAGGACAGACCCCCACGAGGCCCCCCAGAGAGGAGGAAGATCCCACGGAGGAACACATGAGGTTAGGGACCCTTG TTCAGCACCCCAAACAGCCTGCCTGTTTAAAGCAGGCAGCAGGCTTAGGCCTTCCCTGCAACCCCAACACCCACAAGTTTGTTTCTCTAG GAAACACATTCACTGTCTCAGCTGGCTGTTACTCTCTCAGACCATATGGCAAAGTTTTCCAAGAAAATGCCCCGACAGGGGTGCCCAGCA CACTGCCTGAGGGACAACAGACATCAGAACAAACCCCCAGAGAGAAACAGTCAAAATCAGGGCCCGGTGCAGTGTTGTCATGTGGAACCT GCTTTATCCATTGCTGAGTGTTGAATGTGGGTAATGGTTAGGGCTTTCCAGATCTCAGCAGCCAAAGACAGTTATTGTTGGAAGACTGTC ATGTAGATAACCATGAGCAATGGCTCGCCTCAGAATCAGTTCATAAAATTCTATGGTACTGGCCCCTTCGTGGGTATTGTGTGAAATGAG ATGGTGGCGAGGGGTGCGCTGTGGAACTGCCGCAGCCACGCAGGAGGTCCCTGGGGGATGCTTTGGGAAGTCCTTGCCCCTGAGCACTGC CTGATTGCCAGGGCCTGTGGAGGTCTAGGCCGCCTGGCAGAATCTAGCACCGTCCGAATCCCCGCAGGACCCATGGAGCTATGACCACAC CAGGCCATTCAAATGGCTCTGCATTATCTTCCCTTGGAAGGTGGCCACTCCTCGGTGGCAGGGCCTTTCCCTGAGGCTGCAGGCCGTGGG CTGGCAGCCCGTCTCTTGGCATTTCAATTGAAGGTCACCAGGTGCTGGGTTTGAAAGGAAGTCACTGGAGTGCTGCCAGGGGCCGCCCTC CAAGGTTAATGAGAGGCCCACATCCAGGCAAGAACTAATTCAAAAGGCAGATCAGAAACCACAGGAGTCAAAATTATTGCTCCGGCAGTG CTTCCCTTCCTTTCATCCACTGGCCTCGTGTGGTCCATGCAGGGCCACTGTCTGCCCTTTCTGATGCCACGTATTAGGCTTTCTTACTCA GAATTTTGATAGAAAACCATGGGGCCAAGAGCTCTGGAAGCCTGGCCGGAAAGACCAAGGTTCATGCAGCCCAACAAATGATTGTTGAGC ACCTCTCGGAGCCAAAGTCCTTAGGCGAGTGTGGTGACTTCCTGGAAGGAGGATGCAGACTTCCAGAGAGCCCCCCCAACGGACGTGCTG AGAAGGGAGAGGGAGGCGGGGGCTGTAGTCAGGAAGGAGCCAGAGAAGAACAGGGTTTGGGTGCATCCAGAAATATGCCTGCAGTAGGAG GGAGAGGAAGGGGTGCCACCGTCAACGGCTTCCCATCGGAGGTGGTTGGTGCAGATGGAAGTTTCTGTCTGCTGGCCCTCAAGAGAGTGT TTTGCCAGGGACACAGTCTGTTCCTCCTCAGAAAACACCCCCCAAATGCTAACAACATCCCCACCAGCTGCTAGAAGCCCCTTTCCCCTC CCCACCTTGAAGTAGCTCATAGTTCTCTGGGCAGAGCCAGACCATCCAGTGTACCCCAGAGGCCAGTAGGTTCCTGCCCATTTTCCTCTC TGGCTTCCTGCCAAGAATTATGGCAGCTGAGGATGAATGGAGAAGTAAAAACAACTAACACCGCACAACTAACAACTAACACCGCAGTTC CCACCTGGGTTCCACTTAGCAGGAGACATTTCGGAGGGTTTTTTTTGTTTTTGTTCCTGTTTTTTTTTTTTTTGCTGGAATTTGTTTTCT CAGTACTGAAAAGAGAAAAAGTGACAATCTTGTATTTTTAAAAGCCTCGGAAAGGTGATACCATCTGACAGTCATTTTCTCACGTTGGTC TTCTAAAGTCACCTATTTCTTGTGTGTGCACATCACACCATTTCCTGTTTCTTTATAACCCGACAAGGGTAGGAGTGCCTGTTTCCCCTG CTGGGCACACCAGACAATCGTAATCACAAAACAGACACTGAGCCAGGGGCCCAAAGGGTGTGATCATGAGAGTTACCGGGACAGCAGTAG GCATGACAGTCACCAGGAAGGACAAGGGTGCTCTGTTGTTAGTGGCCACACACCAATTTGACAAGGAGTGTTGCGAAATTTTTATTTATT TATTTATTTATTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCGGTGGTACAATCTCGGCTCACTGCAACCTCCACCTCCC AGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGACTACAGGTGCGTGCCACCACACCCAGCTAAATTTTGTGTTTTTAGT AGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTTGAACCCCTGACCTCATGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTA CAGGCATGAGCCACCACGCCCAGCCAAAATATTTTTTTAAAGTCATTTTCCTTAAGCTGCTTGGGCTACATGTGAAATACACTGGACGGT CAACATTCCTGTCTCCTCCCATTTGGGCTGATGCAGCAGATCCAGGGAATGTTACCTGTTTCTGCTGCTAGAAGATCCAGGAAATTGGGA AGGTTACCTGACGCACACATGGATGAAGGCCATCATCTAGAAATGGGGTCAACCACAATTGTGTTAATTCCGTAGTGTCAGGGATTCTTC GGGAAGGTCAACAGTATGAAGGATTCTGACCCCTGTGCCTCCCATTTATGTGATCAGGTGACAGTTAATAACCGTGGAGGTCACACTCAG CCATCCAACAGCCTTACAGTGACCCTACACAAAAGCCCCCAAATTCCAAAGACTTTTTCTTAACCTAAAGGAAGAAATTATTTGTTAATT CCAGTAGAGCAACTGAATATACTGGGCTATTTGTACTTTTTTATAGAGAACTTTAATAATAATTCTTTAAAAATGAGTTTTTAGAACAAA GCAACTGACGATTTCCTAAGATTCCAATGCCCTGGAGCTTGTAGGAGGACTTAGCCTGGGTCAGCTGGAGCACCCCCGACCTGATCTCCC ACTGCCAGATTTTCCCATGCTCCTAGGGTATGGAGTCCACGTGGGAATGACTGCAAGTTCAGGTGGAACTTGGCCGACTGATGCTCTGCG AGTTTTTAATAGACACTGGGGACAACTGCTTAAGGTTTAGAAACTTCCAAACCACAGGAAAGACATTTTTAGTGTCCCCCATCCAGAGGC AGCCCTGGAATAGGATTCCCAGGGGTTTCTGGGACCCCTTTCCTTGCTCCGTGAGGCTCTGTGGCCATCTTTTGGCAGGAGGAGGATGCT TCCTTGGCTCTGTGCCCAGACCCGCCTGGTCCCCAGGTCTCTCACCTTGGGTGAAGATTCAGAGATGCCCTGTAAGGATTTTGCCCACTG GGCAACTCAGAAATACTTCGATCTCCCAAGATATAAGAGGCAGCAGCAAACGTGCCTATTGACGTCTGTTTCATAGTTACCACTTACGCG AGTAGACAGAACTCGGCTTTTCAGAAAATAGGTGTCAAGTCCACTTTATAAGAACCTTTTTTTCTAAAATAAGATAAAAGGTGGCTTTGC ATTTTCTGATTAAACGACTGTGTCTTTGTCACCTCTGCTTAACTTTAGGAGTATCCATTCCTGTGATTGTAGACTTTTGTTGATATTCTT CCTGGAAGAATATCATTCTTTTCTTGAAGGGTTGGTTTACTAGAATATTCAAAATCAATCATGAAGGCAGTTACTATTTTGAGTCTAAAG GTTTTCTAAAAATTAACCTCACATCCCTTCTGTTAGGGTCTTTCAGAATATCTTTTATAAACAGAAGCATTTGAAGTCATTGCTTTTGCT ACATGATTTGTGTGTGTGAAGGACATACCACGTTTAAATCATTAATTGAAAAACATCATATAAGCCCCAACTTTGTTTGGAGGAAGAGAC GGAGGTTGAGGTTTTTCCTTCTGTATAAGCACCTACTGACAAAATGTAGAGGCCATTCAACCGTCAAACACCATTTGGTTATATCGCAGA GGAGACGGATGTGTAAATTACTGCATTGCTTTTTTTTTCAGTTTGTATAACCTCTAATCTCCGTTTGCATGATACGCTTTGTTAGAAACA >1398_1398_1_ACOX1-PRKCA_ACOX1_chr17_73974614_ENST00000293217_PRKCA_chr17_64799990_ENST00000413366_length(amino acids)=187AA_BP= MPSFMHHRHRDSRGSWLPCPCSPAGQCMIWVRVLTRCSSFDPRGKGLVYRKSLGDKRASPPAQNGAAAGQTPTRPPREEEDPTEEHMRLG TLVQHPKQPACLKQAAGLGLPCNPNTHKFVSLGNTFTVSAGCYSLRPYGKVFQENAPTGVPSTLPEGQQTSEQTPREKQSKSGPGAVLSC -------------------------------------------------------------- >1398_1398_2_ACOX1-PRKCA_ACOX1_chr17_73974614_ENST00000301608_PRKCA_chr17_64799990_ENST00000413366_length(transcript)=7201nt_BP=330nt GGATTTAGATTGTCACTGCCACCTCGGTCGGTGCTTACTTCGCTGCCAGCTGGTCGTCGCCATGAACCCGGACCTGCGCAGGGAGCGGGA TTCCGCCAGCTTCAACCCGGAGCTGCTTACACACATCCTGGACGGCAGCCCCGAGAAAACCCGGCGCCGCCGAGAGATCGAGAACATGAT CCTGAACGACCCAGACTTCCAGCATGAGGACTTGAACTTCCTCACTCGCAGCCAGCGTTATGAGGTGGCTGTCAGGAAAAGTGCCATCAT GGTGAAGAAGATGAGGGAGTTTGGCATCGCTGACCCTGATGAAATTATGTGGTTTAAAAATGTGGCAAAGGAGCAGAGAACTTTGACAAG TTCTTCACACGAGGACAGCCCGTCTTAACACCACCTGATCAGCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCTCGTAT GTCAACCCCCAGTTTGTGCACCCCATCTTACAGAGTGCAGTATGAAACTCACCAGCGAGAACAAACACCTCCCCAGCCCCCAGCCCTCCC CGCAGTGGGAAGTGAATCCTTAACCCTAAAATTTTAAGGCCACGGCCTTGTGTCTGATTCCATATGGAGGCCTGAAAATTGTAGGGTTAT TAGTCCAAATGTGATCAACTGTTCAGGGTCTCTCTCTTACAACCAAGAACATTATCTTAGTGGAAGATGGTACGTCATGCTCAGTGTCCA GTTTAATTCTGTAGAAGTTACGTCTGGCTCTAGGTTAACCCTTCCTAGAAAGCAAGCAGACTGTTGCCCCATTTTGGGTACAATTTGATA TACTTTCCATACCCTCCATCTGTGGATTTTTCAGCATTGGAATCCCCCAACCAGAGATGTTAAAGTGAGCCTGTCCCAGGAAACATCTCC ACCCAAGACGTCTTTGGAATCCAAGAACAGGAAGCCAAGAGAGTGAGCAGGGAGGGATTGGGGGTGGGGGAGGCCTCAAAATACCGACTG CGTCCATTCTCTGCCTCCATGGAAACAGCCCCTAGAATCTGAAAGGCCGGGATAAACCTAATCACTGTTCCCAAACATTGACAAATCCTA ACCCAACCATGGTCCAGCAGTTACCAGTTTAAACAAAAAAACCTCAGATGAGTGTTGGGTGAATCTGTCATCTGGTACCCTCCTTGGTTG ATAACTGTCTTGATACTTTTCATTCTTTGTAAGAGGCCAAATCGTCTAAGGACGTTGCTGAACAAGCGTGTGAAATCATTTCAGATCAAG GATAAGCCAGTGTGTACATATGTTCATTTTAATCTCTGGGAGATTATTTTTCCATCCAGGGTGCCATCAGTAATCATGCCACTACTCACC AGTGTTGTTCACCAACACCCACCCCCACACACACCAACATTTTGCTGCCTACCTTGTTATCCTTCTCAAGAAGCTGAAGTGTACGCCCTC TCCCCTTTTGTGCTTATTTATTTAATAGGCTGCAGTGTCGCTTATGAAAGTACGATGTACAGTAACTTAATGGAAGTGCTGACTCTAGCA TCAGCCTCTACCGATTGATTTTCCTCCCTTCTCTAGCCCTGGATGTCCACTTAGGGATAAAAAGAATATGGTTTTGGTTCCCATTTCTAG TTCACGTTGAATGACAGGCCTGGAGCTGTAGAATCAGGAAACCCGGATGCCTAACAGCTCAAAGATGTTTTGTTAATAGAAGGATTTTAA TACGTTTTGCAAATGCATCATGCAATGAATTTTGCATGTTTATAATAAACCTTAATAACAAGTGAATCTATATTATTGATATAATCGTAT CAAGTATAAAGAGAGTATTATAATAATTTTATAAGACACAATTGTGCTCTATTTGTGCAGGTTCTTGTTTCTAATCCTCTTTTCTAATTA AGTTTTAGCTGAATCCCTTGCTTCTGTGCTTTCCCTCCCTGCACATGGGCACTGTATCAGATAGATTACTTTTTAAATGTAGATAAAATT TCAAAAATGAATGGCTAGTTTACGTGATAGATTAGGCTCTTACTACATATGTGTGTGTATATATATGTATTTGATTCTACCTGCAAACAA ATTTTTATTGGTGAGGACTATTTTTGAGCTGACACTCCCTCTTAGTTTCTTCATGTCACCTTTCGTCCTGGTTCCTCCGCCACTCTTCCT CTTGGGGACAACAGGAAGTGTCTGATTCCAGTCTGCCTAGTACGTTGGTACACACGTGGCATTGCCGCAGCACCTGGGCTGACCTTTGTG TGTGCGTGTGTGTGTGTTTCCTTCTTCCCTTCAGCCTGTGACTGTTGCTGACTCCAGGGGTGGGAGGGATGGGGAGACTCCCCTCTTGCT GTGTGTACTGGACACGCAGGAAGCATGCTGTCTTGCTGCCTCTGCAACGACCTGTCGTTTGCTCCAGCATGCACAAACTTCGTGAGACCA ACACAGCCGTGCCCTGCAGGCACCAGCACGTGCTTTTCAGAGGCTGCGGACTTTCTTCCAGCCATTGTGGCATTGGCCTTTCCAGTCTTG GGAGGAGCGCGCTGCTTTGGTGAGACACCCCCATGCAAGGTCCTCAGAGTAGCCGGGTTCTACCACAAACAGAAACAGAATGAAAGTAGC TGTCAGTCCTTGTAGAGAGCCGCTCTGTTTCCTCCCAGAAGCATCTCCCAGCTAAGCTCGCATTATTTTTCTCCTCTGGCTGTTTGCCTG AAGTTCACAGAACACACAACCATGAAAGGCTTTTTGAGGTGAGAGGCCCAGGTGGTCCTGGCAACCCTGAGTAGAAGGAGAGACGGGGTA GGGAACGGGCCCGGCCAGAAAAGAACCATTTCTTCTGCCATCTTTTATGCACCATAGACATCGAGACTCCAGGGGGTCCTGGCTCCCCTG TCCCTGCAGCCCTGCAGGTCAGTGCATGATCTGGGTTCGTGTCCTGACCAGGTGCTCCTCCTTTGATCCGAGGGGAAAGGGACTGGTTTA TAGAAAGAGCCTAGGAGACAAAAGGGCCAGTCCCCCTGCCCAGAATGGAGCAGCAGCAGGACAGACCCCCACGAGGCCCCCCAGAGAGGA GGAAGATCCCACGGAGGAACACATGAGGTTAGGGACCCTTGTTCAGCACCCCAAACAGCCTGCCTGTTTAAAGCAGGCAGCAGGCTTAGG CCTTCCCTGCAACCCCAACACCCACAAGTTTGTTTCTCTAGGAAACACATTCACTGTCTCAGCTGGCTGTTACTCTCTCAGACCATATGG CAAAGTTTTCCAAGAAAATGCCCCGACAGGGGTGCCCAGCACACTGCCTGAGGGACAACAGACATCAGAACAAACCCCCAGAGAGAAACA GTCAAAATCAGGGCCCGGTGCAGTGTTGTCATGTGGAACCTGCTTTATCCATTGCTGAGTGTTGAATGTGGGTAATGGTTAGGGCTTTCC AGATCTCAGCAGCCAAAGACAGTTATTGTTGGAAGACTGTCATGTAGATAACCATGAGCAATGGCTCGCCTCAGAATCAGTTCATAAAAT TCTATGGTACTGGCCCCTTCGTGGGTATTGTGTGAAATGAGATGGTGGCGAGGGGTGCGCTGTGGAACTGCCGCAGCCACGCAGGAGGTC CCTGGGGGATGCTTTGGGAAGTCCTTGCCCCTGAGCACTGCCTGATTGCCAGGGCCTGTGGAGGTCTAGGCCGCCTGGCAGAATCTAGCA CCGTCCGAATCCCCGCAGGACCCATGGAGCTATGACCACACCAGGCCATTCAAATGGCTCTGCATTATCTTCCCTTGGAAGGTGGCCACT CCTCGGTGGCAGGGCCTTTCCCTGAGGCTGCAGGCCGTGGGCTGGCAGCCCGTCTCTTGGCATTTCAATTGAAGGTCACCAGGTGCTGGG TTTGAAAGGAAGTCACTGGAGTGCTGCCAGGGGCCGCCCTCCAAGGTTAATGAGAGGCCCACATCCAGGCAAGAACTAATTCAAAAGGCA GATCAGAAACCACAGGAGTCAAAATTATTGCTCCGGCAGTGCTTCCCTTCCTTTCATCCACTGGCCTCGTGTGGTCCATGCAGGGCCACT GTCTGCCCTTTCTGATGCCACGTATTAGGCTTTCTTACTCAGAATTTTGATAGAAAACCATGGGGCCAAGAGCTCTGGAAGCCTGGCCGG AAAGACCAAGGTTCATGCAGCCCAACAAATGATTGTTGAGCACCTCTCGGAGCCAAAGTCCTTAGGCGAGTGTGGTGACTTCCTGGAAGG AGGATGCAGACTTCCAGAGAGCCCCCCCAACGGACGTGCTGAGAAGGGAGAGGGAGGCGGGGGCTGTAGTCAGGAAGGAGCCAGAGAAGA ACAGGGTTTGGGTGCATCCAGAAATATGCCTGCAGTAGGAGGGAGAGGAAGGGGTGCCACCGTCAACGGCTTCCCATCGGAGGTGGTTGG TGCAGATGGAAGTTTCTGTCTGCTGGCCCTCAAGAGAGTGTTTTGCCAGGGACACAGTCTGTTCCTCCTCAGAAAACACCCCCCAAATGC TAACAACATCCCCACCAGCTGCTAGAAGCCCCTTTCCCCTCCCCACCTTGAAGTAGCTCATAGTTCTCTGGGCAGAGCCAGACCATCCAG TGTACCCCAGAGGCCAGTAGGTTCCTGCCCATTTTCCTCTCTGGCTTCCTGCCAAGAATTATGGCAGCTGAGGATGAATGGAGAAGTAAA AACAACTAACACCGCACAACTAACAACTAACACCGCAGTTCCCACCTGGGTTCCACTTAGCAGGAGACATTTCGGAGGGTTTTTTTTGTT TTTGTTCCTGTTTTTTTTTTTTTTGCTGGAATTTGTTTTCTCAGTACTGAAAAGAGAAAAAGTGACAATCTTGTATTTTTAAAAGCCTCG GAAAGGTGATACCATCTGACAGTCATTTTCTCACGTTGGTCTTCTAAAGTCACCTATTTCTTGTGTGTGCACATCACACCATTTCCTGTT TCTTTATAACCCGACAAGGGTAGGAGTGCCTGTTTCCCCTGCTGGGCACACCAGACAATCGTAATCACAAAACAGACACTGAGCCAGGGG CCCAAAGGGTGTGATCATGAGAGTTACCGGGACAGCAGTAGGCATGACAGTCACCAGGAAGGACAAGGGTGCTCTGTTGTTAGTGGCCAC ACACCAATTTGACAAGGAGTGTTGCGAAATTTTTATTTATTTATTTATTTATTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAG TGCGGTGGTACAATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGACTACA GGTGCGTGCCACCACACCCAGCTAAATTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTTGAACCCCTGACC TCATGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAAAATATTTTTTTAAAGTCATTTT CCTTAAGCTGCTTGGGCTACATGTGAAATACACTGGACGGTCAACATTCCTGTCTCCTCCCATTTGGGCTGATGCAGCAGATCCAGGGAA TGTTACCTGTTTCTGCTGCTAGAAGATCCAGGAAATTGGGAAGGTTACCTGACGCACACATGGATGAAGGCCATCATCTAGAAATGGGGT CAACCACAATTGTGTTAATTCCGTAGTGTCAGGGATTCTTCGGGAAGGTCAACAGTATGAAGGATTCTGACCCCTGTGCCTCCCATTTAT GTGATCAGGTGACAGTTAATAACCGTGGAGGTCACACTCAGCCATCCAACAGCCTTACAGTGACCCTACACAAAAGCCCCCAAATTCCAA AGACTTTTTCTTAACCTAAAGGAAGAAATTATTTGTTAATTCCAGTAGAGCAACTGAATATACTGGGCTATTTGTACTTTTTTATAGAGA ACTTTAATAATAATTCTTTAAAAATGAGTTTTTAGAACAAAGCAACTGACGATTTCCTAAGATTCCAATGCCCTGGAGCTTGTAGGAGGA CTTAGCCTGGGTCAGCTGGAGCACCCCCGACCTGATCTCCCACTGCCAGATTTTCCCATGCTCCTAGGGTATGGAGTCCACGTGGGAATG ACTGCAAGTTCAGGTGGAACTTGGCCGACTGATGCTCTGCGAGTTTTTAATAGACACTGGGGACAACTGCTTAAGGTTTAGAAACTTCCA AACCACAGGAAAGACATTTTTAGTGTCCCCCATCCAGAGGCAGCCCTGGAATAGGATTCCCAGGGGTTTCTGGGACCCCTTTCCTTGCTC CGTGAGGCTCTGTGGCCATCTTTTGGCAGGAGGAGGATGCTTCCTTGGCTCTGTGCCCAGACCCGCCTGGTCCCCAGGTCTCTCACCTTG GGTGAAGATTCAGAGATGCCCTGTAAGGATTTTGCCCACTGGGCAACTCAGAAATACTTCGATCTCCCAAGATATAAGAGGCAGCAGCAA ACGTGCCTATTGACGTCTGTTTCATAGTTACCACTTACGCGAGTAGACAGAACTCGGCTTTTCAGAAAATAGGTGTCAAGTCCACTTTAT AAGAACCTTTTTTTCTAAAATAAGATAAAAGGTGGCTTTGCATTTTCTGATTAAACGACTGTGTCTTTGTCACCTCTGCTTAACTTTAGG AGTATCCATTCCTGTGATTGTAGACTTTTGTTGATATTCTTCCTGGAAGAATATCATTCTTTTCTTGAAGGGTTGGTTTACTAGAATATT CAAAATCAATCATGAAGGCAGTTACTATTTTGAGTCTAAAGGTTTTCTAAAAATTAACCTCACATCCCTTCTGTTAGGGTCTTTCAGAAT ATCTTTTATAAACAGAAGCATTTGAAGTCATTGCTTTTGCTACATGATTTGTGTGTGTGAAGGACATACCACGTTTAAATCATTAATTGA AAAACATCATATAAGCCCCAACTTTGTTTGGAGGAAGAGACGGAGGTTGAGGTTTTTCCTTCTGTATAAGCACCTACTGACAAAATGTAG AGGCCATTCAACCGTCAAACACCATTTGGTTATATCGCAGAGGAGACGGATGTGTAAATTACTGCATTGCTTTTTTTTTCAGTTTGTATA ACCTCTAATCTCCGTTTGCATGATACGCTTTGTTAGAAACATTAATTGTAGTTTGGAAGCAAGTGTGTATGAATAAAGATAATGATCATT >1398_1398_2_ACOX1-PRKCA_ACOX1_chr17_73974614_ENST00000301608_PRKCA_chr17_64799990_ENST00000413366_length(amino acids)=187AA_BP= MPSFMHHRHRDSRGSWLPCPCSPAGQCMIWVRVLTRCSSFDPRGKGLVYRKSLGDKRASPPAQNGAAAGQTPTRPPREEEDPTEEHMRLG TLVQHPKQPACLKQAAGLGLPCNPNTHKFVSLGNTFTVSAGCYSLRPYGKVFQENAPTGVPSTLPEGQQTSEQTPREKQSKSGPGAVLSC -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACOX1-PRKCA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACOX1-PRKCA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACOX1-PRKCA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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