FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CCDC90B-DLG2 (FusionGDB2 ID:13984)

Fusion Gene Summary for CCDC90B-DLG2

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC90B-DLG2
Fusion gene ID: 13984
HgeneTgene
Gene symbol

CCDC90B

DLG2

Gene ID

60492

4355

Gene namecoiled-coil domain containing 90Bmembrane palmitoylated protein 2
SynonymsMDS011|MDS025DLG2
Cytomap

11q14.1

17q21.31

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 90B, mitochondrialMAGUK p55 subfamily member 2discs large, homolog 2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Modification date2020031520200313
UniProtAcc

Q9GZT6

Q15700

Ensembl transtripts involved in fusion geneENST00000529073, ENST00000529689, 
ENST00000455220, ENST00000525503, 
ENST00000525504, ENST00000529611, 
ENST00000330014, ENST00000376106, 
ENST00000398301, ENST00000524982, 
ENST00000531015, ENST00000532653, 
ENST00000537455, ENST00000398304, 
ENST00000404783, ENST00000426717, 
ENST00000472545, ENST00000530800, 
ENST00000280241, ENST00000376104, 
ENST00000398309, ENST00000418306, 
ENST00000543673, 
Fusion gene scores* DoF score5 X 6 X 4=12045 X 44 X 9=17820
# samples 648
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/17820*10)=-5.21431912080077
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC90B [Title/Abstract] AND DLG2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC90B(82996916)-DLG2(83585531), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CCDC90B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DLG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A3AG-06ACCDC90Bchr11

82996916

-DLG2chr11

83585531

-


Top

Fusion Gene ORF analysis for CCDC90B-DLG2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000529073ENST00000330014CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529073ENST00000376106CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529073ENST00000398301CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529073ENST00000524982CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529073ENST00000531015CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529073ENST00000532653CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529073ENST00000537455CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529689ENST00000330014CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529689ENST00000376106CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529689ENST00000398301CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529689ENST00000524982CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529689ENST00000531015CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529689ENST00000532653CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-5UTRENST00000529689ENST00000537455CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-intronENST00000529073ENST00000398304CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-intronENST00000529073ENST00000404783CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-intronENST00000529073ENST00000426717CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-intronENST00000529073ENST00000472545CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-intronENST00000529073ENST00000530800CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-intronENST00000529689ENST00000398304CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-intronENST00000529689ENST00000404783CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-intronENST00000529689ENST00000426717CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-intronENST00000529689ENST00000472545CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
5CDS-intronENST00000529689ENST00000530800CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
Frame-shiftENST00000529073ENST00000280241CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
Frame-shiftENST00000529073ENST00000376104CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
Frame-shiftENST00000529073ENST00000398309CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
Frame-shiftENST00000529073ENST00000418306CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
Frame-shiftENST00000529073ENST00000543673CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
Frame-shiftENST00000529689ENST00000280241CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
Frame-shiftENST00000529689ENST00000376104CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
Frame-shiftENST00000529689ENST00000398309CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
Frame-shiftENST00000529689ENST00000418306CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
Frame-shiftENST00000529689ENST00000543673CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000455220ENST00000280241CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000455220ENST00000376104CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000455220ENST00000398309CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000455220ENST00000418306CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000455220ENST00000543673CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000525503ENST00000280241CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000525503ENST00000376104CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000525503ENST00000398309CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000525503ENST00000418306CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000525503ENST00000543673CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000525504ENST00000280241CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000525504ENST00000376104CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000525504ENST00000398309CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000525504ENST00000418306CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000525504ENST00000543673CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000529611ENST00000280241CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000529611ENST00000376104CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000529611ENST00000398309CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000529611ENST00000418306CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-3CDSENST00000529611ENST00000543673CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000455220ENST00000330014CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000455220ENST00000376106CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000455220ENST00000398301CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000455220ENST00000524982CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000455220ENST00000531015CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000455220ENST00000532653CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000455220ENST00000537455CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525503ENST00000330014CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525503ENST00000376106CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525503ENST00000398301CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525503ENST00000524982CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525503ENST00000531015CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525503ENST00000532653CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525503ENST00000537455CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525504ENST00000330014CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525504ENST00000376106CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525504ENST00000398301CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525504ENST00000524982CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525504ENST00000531015CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525504ENST00000532653CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000525504ENST00000537455CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000529611ENST00000330014CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000529611ENST00000376106CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000529611ENST00000398301CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000529611ENST00000524982CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000529611ENST00000531015CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000529611ENST00000532653CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-5UTRENST00000529611ENST00000537455CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000455220ENST00000398304CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000455220ENST00000404783CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000455220ENST00000426717CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000455220ENST00000472545CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000455220ENST00000530800CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000525503ENST00000398304CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000525503ENST00000404783CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000525503ENST00000426717CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000525503ENST00000472545CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000525503ENST00000530800CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000525504ENST00000398304CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000525504ENST00000404783CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000525504ENST00000426717CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000525504ENST00000472545CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000525504ENST00000530800CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000529611ENST00000398304CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000529611ENST00000404783CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000529611ENST00000426717CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000529611ENST00000472545CCDC90Bchr11

82996916

-DLG2chr11

83585531

-
intron-intronENST00000529611ENST00000530800CCDC90Bchr11

82996916

-DLG2chr11

83585531

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CCDC90B-DLG2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CCDC90B-DLG2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:82996916/:83585531)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC90B

Q9GZT6

DLG2

Q15700

FUNCTION: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for CCDC90B-DLG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CCDC90B-DLG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CCDC90B-DLG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CCDC90B-DLG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource