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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCDC91-NTSR1 (FusionGDB2 ID:13997)

Fusion Gene Summary for CCDC91-NTSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC91-NTSR1
Fusion gene ID: 13997
HgeneTgene
Gene symbol

CCDC91

NTSR1

Gene ID

55297

4923

Gene namecoiled-coil domain containing 91neurotensin receptor 1
SynonymsHSD8|p56NTR
Cytomap

12p11.22

20q13.33

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 91GGA-binding partnerp56 accessory proteinneurotensin receptor type 1NT-R-1NTR1NTRHhigh-affinity levocabastine-insensitive neurotensin receptorneurotensin receptor 1 (high affinity)
Modification date2020031320200313
UniProtAcc

Q7Z6B0

.
Ensembl transtripts involved in fusion geneENST00000540401, ENST00000306172, 
ENST00000381259, ENST00000545336, 
ENST00000381256, ENST00000539107, 
ENST00000370501, ENST00000482259, 
Fusion gene scores* DoF score17 X 9 X 9=13774 X 3 X 4=48
# samples 175
** MAII scorelog2(17/1377*10)=-3.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCDC91 [Title/Abstract] AND NTSR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC91(28544344)-NTSR1(61386037), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNTSR1

GO:0007218

neuropeptide signaling pathway

21725197


check buttonFusion gene breakpoints across CCDC91 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NTSR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-4415-01ACCDC91chr12

28544344

-NTSR1chr20

61386037

+
ChimerDB4LUADTCGA-05-4415-01ACCDC91chr12

28544344

+NTSR1chr20

61386037

+


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Fusion Gene ORF analysis for CCDC91-NTSR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000540401ENST00000370501CCDC91chr12

28544344

+NTSR1chr20

61386037

+
3UTR-intronENST00000540401ENST00000482259CCDC91chr12

28544344

+NTSR1chr20

61386037

+
5CDS-intronENST00000306172ENST00000482259CCDC91chr12

28544344

+NTSR1chr20

61386037

+
5CDS-intronENST00000381259ENST00000482259CCDC91chr12

28544344

+NTSR1chr20

61386037

+
5CDS-intronENST00000545336ENST00000482259CCDC91chr12

28544344

+NTSR1chr20

61386037

+
In-frameENST00000306172ENST00000370501CCDC91chr12

28544344

+NTSR1chr20

61386037

+
In-frameENST00000381259ENST00000370501CCDC91chr12

28544344

+NTSR1chr20

61386037

+
In-frameENST00000545336ENST00000370501CCDC91chr12

28544344

+NTSR1chr20

61386037

+
intron-3CDSENST00000381256ENST00000370501CCDC91chr12

28544344

+NTSR1chr20

61386037

+
intron-3CDSENST00000539107ENST00000370501CCDC91chr12

28544344

+NTSR1chr20

61386037

+
intron-intronENST00000381256ENST00000482259CCDC91chr12

28544344

+NTSR1chr20

61386037

+
intron-intronENST00000539107ENST00000482259CCDC91chr12

28544344

+NTSR1chr20

61386037

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545336CCDC91chr1228544344+ENST00000370501NTSR1chr2061386037+422811814191723434
ENST00000381259CCDC91chr1228544344+ENST00000370501NTSR1chr2061386037+3825778161320434
ENST00000306172CCDC91chr1228544344+ENST00000370501NTSR1chr2061386037+371967201214404

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545336ENST00000370501CCDC91chr1228544344+NTSR1chr2061386037+0.0043895290.99561054
ENST00000381259ENST00000370501CCDC91chr1228544344+NTSR1chr2061386037+0.0054751190.99452496
ENST00000306172ENST00000370501CCDC91chr1228544344+NTSR1chr2061386037+0.01423480.9857653

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Fusion Genomic Features for CCDC91-NTSR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CCDC91chr1228544344+NTSR1chr2061386036+9.64E-070.99999905
CCDC91chr1228544344+NTSR1chr2061386036+9.64E-070.99999905

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CCDC91-NTSR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:28544344/chr20:61386037)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC91

Q7Z6B0

.
FUNCTION: Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC91chr12:28544344chr20:61386037ENST00000306172+611130_209224412.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr20:61386037ENST00000381259+712130_209254442.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr20:61386037ENST00000545336+1116130_209254442.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr20:61386037ENST00000306172+6111_16224412.0RegionNote=GGA1-binding motif
HgeneCCDC91chr12:28544344chr20:61386037ENST00000381259+7121_16254442.0RegionNote=GGA1-binding motif
HgeneCCDC91chr12:28544344chr20:61386037ENST00000545336+11161_16254442.0RegionNote=GGA1-binding motif
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104321_344238419.0RegionNeurotensin binding
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104260_303238419.0Topological domainCytoplasmic
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104326_343238419.0Topological domainExtracellular
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104365_418238419.0Topological domainCytoplasmic
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104235_259238419.0TransmembraneHelical%3B Name%3D5
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104304_325238419.0TransmembraneHelical%3B Name%3D6
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104344_364238419.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC91chr12:28544344chr20:61386037ENST00000306172+611249_407224412.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr20:61386037ENST00000381256+111130_2090406.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr20:61386037ENST00000381256+111249_4070406.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr20:61386037ENST00000381259+712249_407254442.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr20:61386037ENST00000539107+112130_2090406.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr20:61386037ENST00000539107+112249_4070406.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr20:61386037ENST00000545336+1116249_407254442.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr20:61386037ENST00000306172+611210_413224412.0RegionNote=Homodimerization
HgeneCCDC91chr12:28544344chr20:61386037ENST00000381256+1111_160406.0RegionNote=GGA1-binding motif
HgeneCCDC91chr12:28544344chr20:61386037ENST00000381256+111210_4130406.0RegionNote=Homodimerization
HgeneCCDC91chr12:28544344chr20:61386037ENST00000381259+712210_413254442.0RegionNote=Homodimerization
HgeneCCDC91chr12:28544344chr20:61386037ENST00000539107+1121_160406.0RegionNote=GGA1-binding motif
HgeneCCDC91chr12:28544344chr20:61386037ENST00000539107+112210_4130406.0RegionNote=Homodimerization
HgeneCCDC91chr12:28544344chr20:61386037ENST00000545336+1116210_413254442.0RegionNote=Homodimerization
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104123_142238419.0Topological domainExtracellular
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104165_184238419.0Topological domainCytoplasmic
TgeneNTSR1chr12:28544344chr20:61386037ENST00000370501041_67238419.0Topological domainExtracellular
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104206_234238419.0Topological domainExtracellular
TgeneNTSR1chr12:28544344chr20:61386037ENST000003705010489_102238419.0Topological domainCytoplasmic
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104103_122238419.0TransmembraneHelical%3B Name%3D2
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104143_164238419.0TransmembraneHelical%3B Name%3D3
TgeneNTSR1chr12:28544344chr20:61386037ENST0000037050104185_205238419.0TransmembraneHelical%3B Name%3D4
TgeneNTSR1chr12:28544344chr20:61386037ENST000003705010468_88238419.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for CCDC91-NTSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13997_13997_1_CCDC91-NTSR1_CCDC91_chr12_28544344_ENST00000306172_NTSR1_chr20_61386037_ENST00000370501_length(transcript)=3719nt_BP=672nt
ATGCCAATGTGGAATAAAGTATCTGGAGTCCATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCACTCTTCTTCCATTGGC
TGCCTCTCTTCTGATGCCATTATTTCATCACCAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTATTCCAAAAGCACAGATT
CAGCAATCAACACACACTCATCTGGATATCTCACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAACAATTGCCCTTGTGGAT
GATTCTGAGGATCCTGGAGCCAATGTATCTAACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACTCAAAGTATCTGAAGAA
GAAAAACAGAGAATTAAACAGGATGTGGAATCATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAAAGAAAAAGAGCAAGAG
GCCATTTCTTTTCAAGATAGATACAAAGAACTTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGCTGGTCACGAAGCCCTC
AGCATTATTGTGGATGAATATAAGGCACTACTGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACAGTACATTTCTGCAATT
GAGAAACAGGCACACAAGTGTGAGGAGTTGCTAAATGCTCAGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTC
CTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGC
ACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTC
TGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTAC
TTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATC
TTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAGC
AACCACACCCTCTCCAGCAATGCCACCCGCGAGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGGAGCCTGGCCATGGGTC
CTTGCCCCCGACAGACAGAGCAGCCCCCACCCGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGGAGTCTGAGGCCTGGGA
CCCCCCCCTCCCACCCCCTAACCCATGTTTCTCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCCTCCCCCATCTCCTCTT
TGAAAGCCAGAACAAGAGAGCGCTCCTCTCCCAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGGCAAAAGGCAGTTTTCT
TTGTTCTCAGACTAATGGATGGTTCCAGAGAAGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCCGGCTGCTGTTCCCATG
TCCACATCTCTGAGGCCTGCACCCCCTCTGTCTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCTTTGGGCCTCACGTGCA
GACCCTGCCATGCAGACCCATGCCCCCCTCCCCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGCCTGGCAAGCTGGGGGC
CCATCGCCGTGGGGAGTCCCTCCCACCACCCTCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCAAAAAGGACAAAAATGG
GCTGGCCTGGAATGGCCCAGACCCCAGCCTCCCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCTCTGCCAGGACACCACA
TGGGAGGGGGCTCAGGCCTCAGCCTCAAGATCTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGATCAGGGGCCTGGTCTCC
AGCACCTGCCCGAGTGGCCGTGGCCAGGATGGGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGAGGTCTGGAGCCAGGCC
CAGAGCTGGCTTCAGGGTGGGGCCTTGAGAAGGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAAGATGCCAGGTCCCAGG
AACTCAGGCTTCAGGTGAGAAGGAGCGGTGTGTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGACTCATTTGTCACCTTCT
GGCGGCGGCAGCCCTGGCCCCGGCCTCCAAGCAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGCTCCACAGAGCACATGA
CTAGCCAGGCCCCTGGCTTAAGAAGGTCGCCTAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACCAGCCAGGAGCTGGGAG
CCACAGGAAGCAAAAGTCAGCCTTTTCTTCAAGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATGGGCTCTGGGCTGGCTG
CCTGCACCGGCCATGTCGACCCAGGACCCGGACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGGACTCAGTTTCCCCGTC
TGAGAAATGAGAGTCGAATGCTACAGTATCTGCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAACCCCACAAAATCCCTC
TCCAACCACAGGACCCTTCGGCTCACCAAGAACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCCAAACTTTGCCCCCACA
AGCCTGGTCATCAGCCAGGCAGCCCTCCCAGTGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGAGGGGCCTTCCTCCCCC
ACAGAGCCCCCATGACATAGTCTGCTCTGGGCGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTGCAGCCCCTACCCCTGC
TCAGGAGTGGGCTCAGAGTCTAGCAAATGCTAAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGAGCCAGACAGGGCAGCC
TCAGACCCTTCTCTGGGGCTCCTGGACCTTGGGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGATGTGGTCGTTCCGCCC
TCTCAGCTGGATGAGACTGTCCTGGAGGATCCACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCTGAGAGAGGGCAGAGTG
GATGCCCCACTGCCCTAGACCCTCGGTAGACGTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGGCTTTTCCCGTTGATGT
CTTGATGCTCCTATCTGTGCACTTACCGTAGGTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACCTGATCTCGTATCACTA
GCTTGCGGCCAGGTCATGATGTGGCCCCGGAAGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGGAGCCCCTGAGCCGGCC
CCTGGTGACGGCACAGCCCTCACAGCTCAAACGCCCACCCCCACTCCCACCATCTGCAGGTGGTGAAAACAAACCCCGTGTATCTCTCAA

>13997_13997_1_CCDC91-NTSR1_CCDC91_chr12_28544344_ENST00000306172_NTSR1_chr20_61386037_ENST00000370501_length(amino acids)=404AA_BP=223
MPMWNKVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVD
DSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEAL
SIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHS
TFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHI

--------------------------------------------------------------
>13997_13997_2_CCDC91-NTSR1_CCDC91_chr12_28544344_ENST00000381259_NTSR1_chr20_61386037_ENST00000370501_length(transcript)=3825nt_BP=778nt
AGGTGCCACTTGAAGAATGGATGATGATGATTTTGGTGGTTTTGAGGCTGCGGAGACTTTTGATGGTGGAAGTGGTGAAACCCAAACAAC
ATCTCCTGCTATTCCTTGGGCTGCCTTTCCTGCAGTATCTGGAGTCCATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCA
CTCTTCTTCCATTGGCTGCCTCTCTTCTGATGCCATTATTTCATCACCAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTAT
TCCAAAAGCACAGATTCAGCAATCAACACACACTCATCTGGATATCTCACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAAC
AATTGCCCTTGTGGATGATTCTGAGGATCCTGGAGCCAATGTATCTAACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACT
CAAAGTATCTGAAGAAGAAAAACAGAGAATTAAACAGGATGTGGAATCATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAA
AGAAAAAGAGCAAGAGGCCATTTCTTTTCAAGATAGATACAAAGAACTTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGC
TGGTCACGAAGCCCTCAGCATTATTGTGGATGAATATAAGGCACTACTGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACA
GTACATTTCTGCAATTGAGAAACAGGCACACAAGTGTGAGGAGTTGCTAAATGCTCAGGTCAACACCTTCATGTCCTTCATATTCCCCAT
GGTGGTCATCTCGGTCCTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGT
CGGGGGCGAGCACAGCACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGT
CATCGCCTTTGTGGTCTGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTA
TGACTTCTACCACTACTTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGC
CAACTTCCGCCACATCTTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGC
CGACAGCGTGTCCAGCAACCACACCCTCTCCAGCAATGCCACCCGCGAGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGG
AGCCTGGCCATGGGTCCTTGCCCCCGACAGACAGAGCAGCCCCCACCCGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGG
AGTCTGAGGCCTGGGACCCCCCCCTCCCACCCCCTAACCCATGTTTCTCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCC
TCCCCCATCTCCTCTTTGAAAGCCAGAACAAGAGAGCGCTCCTCTCCCAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGG
CAAAAGGCAGTTTTCTTTGTTCTCAGACTAATGGATGGTTCCAGAGAAGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCC
GGCTGCTGTTCCCATGTCCACATCTCTGAGGCCTGCACCCCCTCTGTCTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCT
TTGGGCCTCACGTGCAGACCCTGCCATGCAGACCCATGCCCCCCTCCCCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGC
CTGGCAAGCTGGGGGCCCATCGCCGTGGGGAGTCCCTCCCACCACCCTCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCA
AAAAGGACAAAAATGGGCTGGCCTGGAATGGCCCAGACCCCAGCCTCCCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCT
CTGCCAGGACACCACATGGGAGGGGGCTCAGGCCTCAGCCTCAAGATCTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGAT
CAGGGGCCTGGTCTCCAGCACCTGCCCGAGTGGCCGTGGCCAGGATGGGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGA
GGTCTGGAGCCAGGCCCAGAGCTGGCTTCAGGGTGGGGCCTTGAGAAGGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAA
GATGCCAGGTCCCAGGAACTCAGGCTTCAGGTGAGAAGGAGCGGTGTGTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGAC
TCATTTGTCACCTTCTGGCGGCGGCAGCCCTGGCCCCGGCCTCCAAGCAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGC
TCCACAGAGCACATGACTAGCCAGGCCCCTGGCTTAAGAAGGTCGCCTAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACC
AGCCAGGAGCTGGGAGCCACAGGAAGCAAAAGTCAGCCTTTTCTTCAAGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATG
GGCTCTGGGCTGGCTGCCTGCACCGGCCATGTCGACCCAGGACCCGGACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGG
ACTCAGTTTCCCCGTCTGAGAAATGAGAGTCGAATGCTACAGTATCTGCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAA
CCCCACAAAATCCCTCTCCAACCACAGGACCCTTCGGCTCACCAAGAACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCC
AAACTTTGCCCCCACAAGCCTGGTCATCAGCCAGGCAGCCCTCCCAGTGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGA
GGGGCCTTCCTCCCCCACAGAGCCCCCATGACATAGTCTGCTCTGGGCGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTG
CAGCCCCTACCCCTGCTCAGGAGTGGGCTCAGAGTCTAGCAAATGCTAAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGA
GCCAGACAGGGCAGCCTCAGACCCTTCTCTGGGGCTCCTGGACCTTGGGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGA
TGTGGTCGTTCCGCCCTCTCAGCTGGATGAGACTGTCCTGGAGGATCCACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCT
GAGAGAGGGCAGAGTGGATGCCCCACTGCCCTAGACCCTCGGTAGACGTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGG
CTTTTCCCGTTGATGTCTTGATGCTCCTATCTGTGCACTTACCGTAGGTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACC
TGATCTCGTATCACTAGCTTGCGGCCAGGTCATGATGTGGCCCCGGAAGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGG
AGCCCCTGAGCCGGCCCCTGGTGACGGCACAGCCCTCACAGCTCAAACGCCCACCCCCACTCCCACCATCTGCAGGTGGTGAAAACAAAC

>13997_13997_2_CCDC91-NTSR1_CCDC91_chr12_28544344_ENST00000381259_NTSR1_chr20_61386037_ENST00000370501_length(amino acids)=434AA_BP=253
MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQI
QQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE
AISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQVNTFMSFIFPMVVISV
LNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHY

--------------------------------------------------------------
>13997_13997_3_CCDC91-NTSR1_CCDC91_chr12_28544344_ENST00000545336_NTSR1_chr20_61386037_ENST00000370501_length(transcript)=4228nt_BP=1181nt
TTCCGGGGGCAGAGGTGTTCGAAGCCGGGTGGTGCGTGGGCTACCCCAACCTGTGTGGCTGGGCCGCGGTCTCCCCTCAAGGGCCTGGGG
CCGTGCCTCGGGTGTACGCGTAGGGGTCTGTGTGCTGGGGGTGGCTCACCGGGCAGCGTGGGTGAGCGGCGCAGCGGCGGCAGCGGAGAG
CGAGAGAGGGGAGCAGGCTTCTAACCCTCCTTTATGTGACTCAGAGAAAGGAGACCTCATTCCAAGTTCCAGGATTAATTCTGATGAAAG
TATTCTGTCTCATGCATCTAATACTTTACTTGTGAATGAAGATTCATTATGAGGTGCTATACGTGGATGACCTGCTTAGTTTTAATTTTT
GGAGAAATACATTTTATAAAACATTTTCATCAGATTGCTAAAATTGTGCCACTTGAAGAATGGATGATGATGATTTTGGTGGTTTTGAGG
CTGCGGAGACTTTTGATGGTGGAAGTGGTGAAACCCAAACAACATCTCCTGCTATTCCTTGGGCTGCCTTTCCTGCAGTATCTGGAGTCC
ATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCACTCTTCTTCCATTGGCTGCCTCTCTTCTGATGCCATTATTTCATCAC
CAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTATTCCAAAAGCACAGATTCAGCAATCAACACACACTCATCTGGATATCT
CACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAACAATTGCCCTTGTGGATGATTCTGAGGATCCTGGAGCCAATGTATCTA
ACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACTCAAAGTATCTGAAGAAGAAAAACAGAGAATTAAACAGGATGTGGAAT
CATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAAAGAAAAAGAGCAAGAGGCCATTTCTTTTCAAGATAGATACAAAGAAC
TTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGCTGGTCACGAAGCCCTCAGCATTATTGTGGATGAATATAAGGCACTAC
TGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACAGTACATTTCTGCAATTGAGAAACAGGCACACAAGTGTGAGGAGTTGC
TAAATGCTCAGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTCCTGAACACCATCATCGCCAACAAGCTGACCG
TCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGCACATTCAGCATGGCCATCGAGCCTGGCAGGG
TCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTCTGCTGGCTGCCCTACCACGTGCGGCGCCTCA
TGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTACTTCTACATGGTGACCAACGCACTCTTCTACG
TCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATCTTCCTGGCCACACTGGCCTGCCTCTGCCCGG
TGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAGCAACCACACCCTCTCCAGCAATGCCACCCGCG
AGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGGAGCCTGGCCATGGGTCCTTGCCCCCGACAGACAGAGCAGCCCCCACC
CGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGGAGTCTGAGGCCTGGGACCCCCCCCTCCCACCCCCTAACCCATGTTTC
TCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCCTCCCCCATCTCCTCTTTGAAAGCCAGAACAAGAGAGCGCTCCTCTCC
CAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGGCAAAAGGCAGTTTTCTTTGTTCTCAGACTAATGGATGGTTCCAGAGA
AGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCCGGCTGCTGTTCCCATGTCCACATCTCTGAGGCCTGCACCCCCTCTGT
CTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCTTTGGGCCTCACGTGCAGACCCTGCCATGCAGACCCATGCCCCCCTCC
CCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGCCTGGCAAGCTGGGGGCCCATCGCCGTGGGGAGTCCCTCCCACCACCC
TCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCAAAAAGGACAAAAATGGGCTGGCCTGGAATGGCCCAGACCCCAGCCTC
CCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCTCTGCCAGGACACCACATGGGAGGGGGCTCAGGCCTCAGCCTCAAGAT
CTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGATCAGGGGCCTGGTCTCCAGCACCTGCCCGAGTGGCCGTGGCCAGGATG
GGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGAGGTCTGGAGCCAGGCCCAGAGCTGGCTTCAGGGTGGGGCCTTGAGAA
GGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAAGATGCCAGGTCCCAGGAACTCAGGCTTCAGGTGAGAAGGAGCGGTGT
GTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGACTCATTTGTCACCTTCTGGCGGCGGCAGCCCTGGCCCCGGCCTCCAAG
CAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGCTCCACAGAGCACATGACTAGCCAGGCCCCTGGCTTAAGAAGGTCGCC
TAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACCAGCCAGGAGCTGGGAGCCACAGGAAGCAAAAGTCAGCCTTTTCTTCA
AGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATGGGCTCTGGGCTGGCTGCCTGCACCGGCCATGTCGACCCAGGACCCGG
ACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGGACTCAGTTTCCCCGTCTGAGAAATGAGAGTCGAATGCTACAGTATCT
GCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAACCCCACAAAATCCCTCTCCAACCACAGGACCCTTCGGCTCACCAAGA
ACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCCAAACTTTGCCCCCACAAGCCTGGTCATCAGCCAGGCAGCCCTCCCAG
TGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGAGGGGCCTTCCTCCCCCACAGAGCCCCCATGACATAGTCTGCTCTGGG
CGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTGCAGCCCCTACCCCTGCTCAGGAGTGGGCTCAGAGTCTAGCAAATGCT
AAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGAGCCAGACAGGGCAGCCTCAGACCCTTCTCTGGGGCTCCTGGACCTTG
GGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGATGTGGTCGTTCCGCCCTCTCAGCTGGATGAGACTGTCCTGGAGGATC
CACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCTGAGAGAGGGCAGAGTGGATGCCCCACTGCCCTAGACCCTCGGTAGAC
GTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGGCTTTTCCCGTTGATGTCTTGATGCTCCTATCTGTGCACTTACCGTAG
GTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACCTGATCTCGTATCACTAGCTTGCGGCCAGGTCATGATGTGGCCCCGGA
AGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGGAGCCCCTGAGCCGGCCCCTGGTGACGGCACAGCCCTCACAGCTCAAA

>13997_13997_3_CCDC91-NTSR1_CCDC91_chr12_28544344_ENST00000545336_NTSR1_chr20_61386037_ENST00000370501_length(amino acids)=434AA_BP=253
MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQI
QQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE
AISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQVNTFMSFIFPMVVISV
LNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCDC91-NTSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCDC91-NTSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCDC91-NTSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource