Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ACOXL-DDR1 (FusionGDB2 ID:1410)

Fusion Gene Summary for ACOXL-DDR1

Fusion gene summary

Fusion gene information	Fusion gene name: ACOXL-DDR1
	Fusion gene ID: 1410
		Hgene	Tgene
	Gene symbol	ACOXL	DDR1
	Gene ID	55289	780
	Gene name	acyl-CoA oxidase like	discoidin domain receptor tyrosine kinase 1
	Synonyms	-	CAK\|CD167\|DDR\|EDDR1\|HGK2\|MCK10\|NEP\|NTRK4\|PTK3\|PTK3A\|RTK6\|TRKE
	Cytomap	2q13	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	acyl-coenzyme A oxidase-like proteinacyl-CoA oxidase-like protein	epithelial discoidin domain-containing receptor 1CD167 antigen-like family member APTK3A protein tyrosine kinase 3Acell adhesion kinasemammary carcinoma kinase 10neuroepithelial tyrosine kinaseneurotrophic tyrosine kinase, receptor, type 4protein-t
	Modification date	20200313	20200329
	UniProtAcc	.	Q08345
	Ensembl transtripts involved in fusion gene	ENST00000340561, ENST00000389811, ENST00000439055, ENST00000496981,	ENST00000259875, ENST00000324771, ENST00000361741, ENST00000376567, ENST00000376568, ENST00000376569, ENST00000376570, ENST00000376575, ENST00000383377, ENST00000400410, ENST00000400411, ENST00000400414, ENST00000400486, ENST00000400488, ENST00000400489, ENST00000400491, ENST00000400492, ENST00000412329, ENST00000415092, ENST00000418800, ENST00000419412, ENST00000421229, ENST00000422628, ENST00000427053, ENST00000429699, ENST00000430933, ENST00000434428, ENST00000446312, ENST00000449518, ENST00000452441, ENST00000453510, ENST00000454612, ENST00000454774, ENST00000462241, ENST00000468225, ENST00000483193, ENST00000487780, ENST00000488414, ENST00000490712, ENST00000508312, ENST00000508472, ENST00000513240, ENST00000548133, ENST00000548693, ENST00000548962, ENST00000549026, ENST00000550384, ENST00000550395, ENST00000550666, ENST00000552068, ENST00000552434, ENST00000552721, ENST00000553015,
Fusion gene scores	* DoF score	7 X 7 X 2=98	6 X 6 X 3=108
	# samples	6	6
	** MAII score	log2(6/98*10)=-0.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ACOXL [Title/Abstract] AND DDR1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACOXL(111850786)-DDR1(30867930), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DDR1	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	9659899\|21044884
Tgene	DDR1	GO:0038083	peptidyl-tyrosine autophosphorylation	21044884
Tgene	DDR1	GO:0046777	protein autophosphorylation	9659899

Fusion gene breakpoints across ACOXL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DDR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AA551699	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-

Top

Fusion Gene ORF analysis for ACOXL-DDR1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000340561	ENST00000259875	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000324771	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000361741	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000376567	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000376568	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000376569	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000376570	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000376575	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000383377	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000400410	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000400411	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000400414	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000400486	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000400488	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000400489	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000400491	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000400492	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000412329	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000415092	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000418800	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000419412	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000421229	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000422628	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000427053	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000429699	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000430933	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000434428	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000446312	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000449518	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000452441	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000453510	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000454612	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000454774	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000462241	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000468225	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000483193	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000487780	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000488414	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000490712	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000508312	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000508472	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000513240	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000548133	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000548693	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000548962	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000549026	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000550384	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000550395	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000550666	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000552068	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000552434	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000552721	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000340561	ENST00000553015	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000259875	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000324771	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000361741	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000376567	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000376568	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000376569	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000376570	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000376575	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000383377	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000400410	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000400411	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000400414	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000400486	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000400488	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000400489	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000400491	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000400492	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000412329	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000415092	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000418800	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000419412	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000421229	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000422628	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000427053	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000429699	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000430933	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000434428	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000446312	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000449518	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000452441	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000453510	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000454612	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000454774	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000462241	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000468225	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000483193	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000487780	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000488414	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000490712	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000508312	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000508472	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000513240	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000548133	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000548693	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000548962	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000549026	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000550384	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000550395	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000550666	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000552068	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000552434	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000552721	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000389811	ENST00000553015	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000259875	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000324771	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000361741	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000376567	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000376568	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000376569	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000376570	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000376575	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000383377	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000400410	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000400411	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000400414	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000400486	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000400488	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000400489	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000400491	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000400492	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000412329	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000415092	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000418800	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000419412	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000421229	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000422628	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000427053	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000429699	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000430933	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000434428	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000446312	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000449518	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000452441	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000453510	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000454612	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000454774	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000462241	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000468225	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000483193	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000487780	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000488414	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000490712	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000508312	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000508472	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000513240	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000548133	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000548693	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000548962	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000549026	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000550384	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000550395	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000550666	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000552068	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000552434	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000552721	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000439055	ENST00000553015	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000259875	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000324771	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000361741	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000376567	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000376568	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000376569	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000376570	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000376575	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000383377	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000400410	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000400411	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000400414	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000400486	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000400488	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000400489	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000400491	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000400492	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000412329	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000415092	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000418800	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000419412	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000421229	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000422628	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000427053	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000429699	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000430933	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000434428	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000446312	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000449518	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000452441	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000453510	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000454612	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000454774	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000462241	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000468225	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000483193	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000487780	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000488414	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000490712	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000508312	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000508472	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000513240	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000548133	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000548693	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000548962	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000549026	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000550384	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000550395	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000550666	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000552068	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000552434	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000552721	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-
intron-intron	ENST00000496981	ENST00000553015	ACOXL	chr2	111850786	-	DDR1	chr6	30867930	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for ACOXL-DDR1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ACOXL-DDR1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:111850786/:30867930)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DDR1 Q08345
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. {ECO:0000250, ECO:0000269\|PubMed:12065315, ECO:0000269\|PubMed:16234985, ECO:0000269\|PubMed:16337946, ECO:0000269\|PubMed:19401332, ECO:0000269\|PubMed:20093046, ECO:0000269\|PubMed:20432435, ECO:0000269\|PubMed:20884741, ECO:0000269\|PubMed:21044884, ECO:0000269\|PubMed:9659899}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for ACOXL-DDR1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ACOXL-DDR1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ACOXL-DDR1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ACOXL-DDR1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source