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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCNYL1-IDH1 (FusionGDB2 ID:14220)

Fusion Gene Summary for CCNYL1-IDH1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCNYL1-IDH1
Fusion gene ID: 14220
HgeneTgene
Gene symbol

CCNYL1

IDH1

Gene ID

151195

3417

Gene namecyclin Y like 1isocitrate dehydrogenase (NADP(+)) 1
Synonyms-HEL-216|HEL-S-26|IDCD|IDH|IDP|IDPC|PICD
Cytomap

2q33.3

2q34

Type of geneprotein-codingprotein-coding
Descriptioncyclin-Y-like protein 1isocitrate dehydrogenase [NADP] cytoplasmicNADP(+)-specific ICDHNADP-dependent isocitrate dehydrogenase, cytosolicNADP-dependent isocitrate dehydrogenase, peroxisomalepididymis luminal protein 216epididymis secretory protein Li 26epididymis secretor
Modification date2020031320200313
UniProtAcc.

O75874

Ensembl transtripts involved in fusion geneENST00000295414, ENST00000339882, 
ENST00000392209, ENST00000420822, 
ENST00000468768, 		ENST00000345146, 
ENST00000415913, ENST00000446179, 
Fusion gene scores* DoF score4 X 4 X 2=326 X 5 X 3=90
# samples 46
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCNYL1 [Title/Abstract] AND IDH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCNYL1(208576841)-IDH1(209104729), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIDH1

GO:0006102

isocitrate metabolic process

10521434|19935646|20171178

TgeneIDH1

GO:0006103

2-oxoglutarate metabolic process

19935646


check buttonFusion gene breakpoints across CCNYL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IDH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABC065703CCNYL1chr2

208576841

+IDH1chr2

209104729

-


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Fusion Gene ORF analysis for CCNYL1-IDH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000295414ENST00000345146CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000295414ENST00000415913CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000295414ENST00000446179CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000339882ENST00000345146CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000339882ENST00000415913CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000339882ENST00000446179CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000392209ENST00000345146CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000392209ENST00000415913CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000392209ENST00000446179CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000420822ENST00000345146CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000420822ENST00000415913CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000420822ENST00000446179CCNYL1chr2

208576841

+IDH1chr2

209104729

-
intron-3CDSENST00000468768ENST00000345146CCNYL1chr2

208576841

+IDH1chr2

209104729

-
intron-3CDSENST00000468768ENST00000415913CCNYL1chr2

208576841

+IDH1chr2

209104729

-
intron-3CDSENST00000468768ENST00000446179CCNYL1chr2

208576841

+IDH1chr2

209104729

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392209CCNYL1chr2208576841+ENST00000345146IDH1chr2209104729-1572325153719188
ENST00000392209CCNYL1chr2208576841+ENST00000446179IDH1chr2209104729-1567325153719188
ENST00000392209CCNYL1chr2208576841+ENST00000415913IDH1chr2209104729-1534325153719188
ENST00000420822CCNYL1chr2208576841+ENST00000345146IDH1chr2209104729-1716469249863204
ENST00000420822CCNYL1chr2208576841+ENST00000446179IDH1chr2209104729-1711469249863204
ENST00000420822CCNYL1chr2208576841+ENST00000415913IDH1chr2209104729-1678469249863204
ENST00000295414CCNYL1chr2208576841+ENST00000345146IDH1chr2209104729-1678431211825204
ENST00000295414CCNYL1chr2208576841+ENST00000446179IDH1chr2209104729-1673431211825204
ENST00000295414CCNYL1chr2208576841+ENST00000415913IDH1chr2209104729-1640431211825204
ENST00000339882CCNYL1chr2208576841+ENST00000345146IDH1chr2209104729-1613366146760204
ENST00000339882CCNYL1chr2208576841+ENST00000446179IDH1chr2209104729-1608366146760204
ENST00000339882CCNYL1chr2208576841+ENST00000415913IDH1chr2209104729-1575366146760204

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392209ENST00000345146CCNYL1chr2208576841+IDH1chr2209104729-0.011376030.988624
ENST00000392209ENST00000446179CCNYL1chr2208576841+IDH1chr2209104729-0.0115675240.98843247
ENST00000392209ENST00000415913CCNYL1chr2208576841+IDH1chr2209104729-0.0106216990.9893783
ENST00000420822ENST00000345146CCNYL1chr2208576841+IDH1chr2209104729-0.001489110.9985109
ENST00000420822ENST00000446179CCNYL1chr2208576841+IDH1chr2209104729-0.0014680510.99853194
ENST00000420822ENST00000415913CCNYL1chr2208576841+IDH1chr2209104729-0.0014739870.99852604
ENST00000295414ENST00000345146CCNYL1chr2208576841+IDH1chr2209104729-0.0012263570.99877363
ENST00000295414ENST00000446179CCNYL1chr2208576841+IDH1chr2209104729-0.0012305070.99876946
ENST00000295414ENST00000415913CCNYL1chr2208576841+IDH1chr2209104729-0.0014198890.9985801
ENST00000339882ENST00000345146CCNYL1chr2208576841+IDH1chr2209104729-0.0015704840.9984295
ENST00000339882ENST00000446179CCNYL1chr2208576841+IDH1chr2209104729-0.0015726480.9984274
ENST00000339882ENST00000415913CCNYL1chr2208576841+IDH1chr2209104729-0.0016716850.99832827

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Fusion Genomic Features for CCNYL1-IDH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCNYL1-IDH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:208576841/chr2:209104729)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IDH1

O75874

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIDH1chr2:208576841chr2:209104729ENST00000345146610310_315283415.0Nucleotide bindingNADP
TgeneIDH1chr2:208576841chr2:209104729ENST00000415913610310_315283415.0Nucleotide bindingNADP
TgeneIDH1chr2:208576841chr2:209104729ENST00000446179610310_315283415.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCNYL1chr2:208576841chr2:209104729ENST00000295414+110145_26773360.0DomainNote=Cyclin N-terminal
HgeneCCNYL1chr2:208576841chr2:209104729ENST00000339882+18145_26773309.0DomainNote=Cyclin N-terminal
HgeneCCNYL1chr2:208576841chr2:209104729ENST00000392209+211145_2673290.0DomainNote=Cyclin N-terminal
TgeneIDH1chr2:208576841chr2:209104729ENST0000034514661075_77283415.0Nucleotide bindingNADP
TgeneIDH1chr2:208576841chr2:209104729ENST0000041591361075_77283415.0Nucleotide bindingNADP
TgeneIDH1chr2:208576841chr2:209104729ENST0000044617961075_77283415.0Nucleotide bindingNADP
TgeneIDH1chr2:208576841chr2:209104729ENST0000034514661094_100283415.0RegionSubstrate binding
TgeneIDH1chr2:208576841chr2:209104729ENST0000041591361094_100283415.0RegionSubstrate binding
TgeneIDH1chr2:208576841chr2:209104729ENST0000044617961094_100283415.0RegionSubstrate binding


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Fusion Gene Sequence for CCNYL1-IDH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14220_14220_1_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000295414_IDH1_chr2_209104729_ENST00000345146_length(transcript)=1678nt_BP=431nt
GTGCGGCCGAGGCCCGAGCCCTGCCCGGGGCCGGGCCGCGGGGCGGGCGGGCGAACCGCGGGCGAGGCGGCGTCTGCTTGCGCGGTGCAG
CCCCAGCGTAGCCCGGGGCTGCCGGTGCCGGCCGCGCCATTGTTGGGGGAGGGGGCGGCTGTTGAGGGCGGCGGAGTAGGGGGCGAGCGA
AGGCGGTGGCAGAGAGGAGCGGAGGCTTCCCATGGGGAACACGCTGACCTGTTGCGTGTCCCCCAATGCCAGCCCCAAGCTGGGCCGGCG
CGCGGGGTCGGCGGAGCTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCCGGGGACGCGGTGGCGGTAGCGCCCGCTGTGGTGGAGCC
TGCCGAGTTGGATTTCGGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGCGACCGCGAGATGCCCGAAGGGTATGGCTCTCTCGGCAT
GATGACCAGCGTGCTGGTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCCGTCACTACCGCATGTACCA
GAAAGGACAGGAGACGTCCACCAATCCCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTAGCCCACAGAGCAAAGCTTGATAACAATAA
AGAGCTTGCCTTCTTTGCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATTGAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCAT
TAAAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAACTTGGAGAAAACTTGAAGATCAAACTAGC
TCAGGCCAAACTTTAAGTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTGGTAACTAGGTCTACAGGTTTACATTTTTCTGTGTTACA
CTCAAGGATAAAGGCAAAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTTATCTTTTCTATAAGTTTACAGCCTTTTTCTTATATATA
CAGTTATTGCCACCTTTGTGAACATGGCAAGGGACTTTTTTACAATTTTTATTTTATTTTCTAGTACCAGCCTAGGAATTCGGTTAGTAC
TCATTTGTATTCACTGTCACTTTTTCTCATGTTCTAATTATAAATGACCAAAATCAAGATTGCTCAAAAGGGTAAATGATAGCCACAGTA
TTGCTCCCTAAAATATGCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTCCATGACCTTGGGCACAGGGAAGTTCTGGTGTCATAGAT
ATCCCGTTTTGTGAGGTAGAGCTGTGCATTAAACTTGCACATGACTGGAACGAAGTAGGAGTGCAACTCAAATGTGTTGAAGATACTGCA
GTCATTTTTGTAAAGACCTTGCTGAATGTTTCCAATAGACTAAATACTGTTTAGGCCGCAGGAGAGTTTGGAATCCGGAATAAATACTAC
CTGGAGGTTTGTCCTCTCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAATATTATACTACTCTAAATAGCATATTTCATCCAAGTGC
AATAATGTAAGCTGAATCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTTTTATATAAATGTGATTTCTCAGAAATTGATATTAAACA

>14220_14220_1_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000295414_IDH1_chr2_209104729_ENST00000345146_length(amino acids)=204AA_BP=73
MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD

--------------------------------------------------------------
>14220_14220_2_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000295414_IDH1_chr2_209104729_ENST00000415913_length(transcript)=1640nt_BP=431nt
GTGCGGCCGAGGCCCGAGCCCTGCCCGGGGCCGGGCCGCGGGGCGGGCGGGCGAACCGCGGGCGAGGCGGCGTCTGCTTGCGCGGTGCAG
CCCCAGCGTAGCCCGGGGCTGCCGGTGCCGGCCGCGCCATTGTTGGGGGAGGGGGCGGCTGTTGAGGGCGGCGGAGTAGGGGGCGAGCGA
AGGCGGTGGCAGAGAGGAGCGGAGGCTTCCCATGGGGAACACGCTGACCTGTTGCGTGTCCCCCAATGCCAGCCCCAAGCTGGGCCGGCG
CGCGGGGTCGGCGGAGCTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCCGGGGACGCGGTGGCGGTAGCGCCCGCTGTGGTGGAGCC
TGCCGAGTTGGATTTCGGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGCGACCGCGAGATGCCCGAAGGGTATGGCTCTCTCGGCAT
GATGACCAGCGTGCTGGTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCCGTCACTACCGCATGTACCA
GAAAGGACAGGAGACGTCCACCAATCCCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTAGCCCACAGAGCAAAGCTTGATAACAATAA
AGAGCTTGCCTTCTTTGCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATTGAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCAT
TAAAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAACTTGGAGAAAACTTGAAGATCAAACTAGC
TCAGGCCAAACTTTAAGTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTGGTAACTAGGTCTACAGGTTTACATTTTTCTGTGTTACA
CTCAAGGATAAAGGCAAAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTTATCTTTTCTATAAGTTTACAGCCTTTTTCTTATATATA
CAGTTATTGCCACCTTTGTGAACATGGCAAGGGACTTTTTTACAATTTTTATTTTATTTTCTAGTACCAGCCTAGGAATTCGGTTAGTAC
TCATTTGTATTCACTGTCACTTTTTCTCATGTTCTAATTATAAATGACCAAAATCAAGATTGCTCAAAAGGGTAAATGATAGCCACAGTA
TTGCTCCCTAAAATATGCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTCCATGACCTTGGGCACAGGGAAGTTCTGGTGTCATAGAT
ATCCCGTTTTGTGAGGTAGAGCTGTGCATTAAACTTGCACATGACTGGAACGAAGTAGGAGTGCAACTCAAATGTGTTGAAGATACTGCA
GTCATTTTTGTAAAGACCTTGCTGAATGTTTCCAATAGACTAAATACTGTTTAGGCCGCAGGAGAGTTTGGAATCCGGAATAAATACTAC
CTGGAGGTTTGTCCTCTCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAATATTATACTACTCTAAATAGCATATTTCATCCAAGTGC
AATAATGTAAGCTGAATCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTTTTATATAAATGTGATTTCTCAGAAATTGATATTAAACA

>14220_14220_2_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000295414_IDH1_chr2_209104729_ENST00000415913_length(amino acids)=204AA_BP=73
MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD

--------------------------------------------------------------
>14220_14220_3_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000295414_IDH1_chr2_209104729_ENST00000446179_length(transcript)=1673nt_BP=431nt
GTGCGGCCGAGGCCCGAGCCCTGCCCGGGGCCGGGCCGCGGGGCGGGCGGGCGAACCGCGGGCGAGGCGGCGTCTGCTTGCGCGGTGCAG
CCCCAGCGTAGCCCGGGGCTGCCGGTGCCGGCCGCGCCATTGTTGGGGGAGGGGGCGGCTGTTGAGGGCGGCGGAGTAGGGGGCGAGCGA
AGGCGGTGGCAGAGAGGAGCGGAGGCTTCCCATGGGGAACACGCTGACCTGTTGCGTGTCCCCCAATGCCAGCCCCAAGCTGGGCCGGCG
CGCGGGGTCGGCGGAGCTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCCGGGGACGCGGTGGCGGTAGCGCCCGCTGTGGTGGAGCC
TGCCGAGTTGGATTTCGGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGCGACCGCGAGATGCCCGAAGGGTATGGCTCTCTCGGCAT
GATGACCAGCGTGCTGGTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCCGTCACTACCGCATGTACCA
GAAAGGACAGGAGACGTCCACCAATCCCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTAGCCCACAGAGCAAAGCTTGATAACAATAA
AGAGCTTGCCTTCTTTGCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATTGAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCAT
TAAAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAACTTGGAGAAAACTTGAAGATCAAACTAGC
TCAGGCCAAACTTTAAGTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTGGTAACTAGGTCTACAGGTTTACATTTTTCTGTGTTACA
CTCAAGGATAAAGGCAAAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTTATCTTTTCTATAAGTTTACAGCCTTTTTCTTATATATA
CAGTTATTGCCACCTTTGTGAACATGGCAAGGGACTTTTTTACAATTTTTATTTTATTTTCTAGTACCAGCCTAGGAATTCGGTTAGTAC
TCATTTGTATTCACTGTCACTTTTTCTCATGTTCTAATTATAAATGACCAAAATCAAGATTGCTCAAAAGGGTAAATGATAGCCACAGTA
TTGCTCCCTAAAATATGCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTCCATGACCTTGGGCACAGGGAAGTTCTGGTGTCATAGAT
ATCCCGTTTTGTGAGGTAGAGCTGTGCATTAAACTTGCACATGACTGGAACGAAGTAGGAGTGCAACTCAAATGTGTTGAAGATACTGCA
GTCATTTTTGTAAAGACCTTGCTGAATGTTTCCAATAGACTAAATACTGTTTAGGCCGCAGGAGAGTTTGGAATCCGGAATAAATACTAC
CTGGAGGTTTGTCCTCTCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAATATTATACTACTCTAAATAGCATATTTCATCCAAGTGC
AATAATGTAAGCTGAATCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTTTTATATAAATGTGATTTCTCAGAAATTGATATTAAACA

>14220_14220_3_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000295414_IDH1_chr2_209104729_ENST00000446179_length(amino acids)=204AA_BP=73
MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD

--------------------------------------------------------------
>14220_14220_4_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000339882_IDH1_chr2_209104729_ENST00000345146_length(transcript)=1613nt_BP=366nt
GGCGGCGTCTGCTTGCGCGGTGCAGCCCCAGCGTAGCCCGGGGCTGCCGGTGCCGGCCGCGCCATTGTTGGGGGAGGGGGCGGCTGTTGA
GGGCGGCGGAGTAGGGGGCGAGCGAAGGCGGTGGCAGAGAGGAGCGGAGGCTTCCCATGGGGAACACGCTGACCTGTTGCGTGTCCCCCA
ATGCCAGCCCCAAGCTGGGCCGGCGCGCGGGGTCGGCGGAGCTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCCGGGGACGCGGTGG
CGGTAGCGCCCGCTGTGGTGGAGCCTGCCGAGTTGGATTTCGGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGCGACCGCGAGATGC
CCGAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTGGTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCTGCCCACGGGACTG
TAACCCGTCACTACCGCATGTACCAGAAAGGACAGGAGACGTCCACCAATCCCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTAGCCC
ACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTTGCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATTGAGGCTGGCTTCA
TGACCAAGGACTTGGCTGCTTGCATTAAAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAACTTG
GAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAAGTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTGGTAACTAGGTCTA
CAGGTTTACATTTTTCTGTGTTACACTCAAGGATAAAGGCAAAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTTATCTTTTCTATAA
GTTTACAGCCTTTTTCTTATATATACAGTTATTGCCACCTTTGTGAACATGGCAAGGGACTTTTTTACAATTTTTATTTTATTTTCTAGT
ACCAGCCTAGGAATTCGGTTAGTACTCATTTGTATTCACTGTCACTTTTTCTCATGTTCTAATTATAAATGACCAAAATCAAGATTGCTC
AAAAGGGTAAATGATAGCCACAGTATTGCTCCCTAAAATATGCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTCCATGACCTTGGGC
ACAGGGAAGTTCTGGTGTCATAGATATCCCGTTTTGTGAGGTAGAGCTGTGCATTAAACTTGCACATGACTGGAACGAAGTAGGAGTGCA
ACTCAAATGTGTTGAAGATACTGCAGTCATTTTTGTAAAGACCTTGCTGAATGTTTCCAATAGACTAAATACTGTTTAGGCCGCAGGAGA
GTTTGGAATCCGGAATAAATACTACCTGGAGGTTTGTCCTCTCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAATATTATACTACTC
TAAATAGCATATTTCATCCAAGTGCAATAATGTAAGCTGAATCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTTTTATATAAATGTG

>14220_14220_4_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000339882_IDH1_chr2_209104729_ENST00000345146_length(amino acids)=204AA_BP=73
MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD

--------------------------------------------------------------
>14220_14220_5_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000339882_IDH1_chr2_209104729_ENST00000415913_length(transcript)=1575nt_BP=366nt
GGCGGCGTCTGCTTGCGCGGTGCAGCCCCAGCGTAGCCCGGGGCTGCCGGTGCCGGCCGCGCCATTGTTGGGGGAGGGGGCGGCTGTTGA
GGGCGGCGGAGTAGGGGGCGAGCGAAGGCGGTGGCAGAGAGGAGCGGAGGCTTCCCATGGGGAACACGCTGACCTGTTGCGTGTCCCCCA
ATGCCAGCCCCAAGCTGGGCCGGCGCGCGGGGTCGGCGGAGCTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCCGGGGACGCGGTGG
CGGTAGCGCCCGCTGTGGTGGAGCCTGCCGAGTTGGATTTCGGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGCGACCGCGAGATGC
CCGAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTGGTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCTGCCCACGGGACTG
TAACCCGTCACTACCGCATGTACCAGAAAGGACAGGAGACGTCCACCAATCCCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTAGCCC
ACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTTGCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATTGAGGCTGGCTTCA
TGACCAAGGACTTGGCTGCTTGCATTAAAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAACTTG
GAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAAGTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTGGTAACTAGGTCTA
CAGGTTTACATTTTTCTGTGTTACACTCAAGGATAAAGGCAAAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTTATCTTTTCTATAA
GTTTACAGCCTTTTTCTTATATATACAGTTATTGCCACCTTTGTGAACATGGCAAGGGACTTTTTTACAATTTTTATTTTATTTTCTAGT
ACCAGCCTAGGAATTCGGTTAGTACTCATTTGTATTCACTGTCACTTTTTCTCATGTTCTAATTATAAATGACCAAAATCAAGATTGCTC
AAAAGGGTAAATGATAGCCACAGTATTGCTCCCTAAAATATGCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTCCATGACCTTGGGC
ACAGGGAAGTTCTGGTGTCATAGATATCCCGTTTTGTGAGGTAGAGCTGTGCATTAAACTTGCACATGACTGGAACGAAGTAGGAGTGCA
ACTCAAATGTGTTGAAGATACTGCAGTCATTTTTGTAAAGACCTTGCTGAATGTTTCCAATAGACTAAATACTGTTTAGGCCGCAGGAGA
GTTTGGAATCCGGAATAAATACTACCTGGAGGTTTGTCCTCTCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAATATTATACTACTC
TAAATAGCATATTTCATCCAAGTGCAATAATGTAAGCTGAATCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTTTTATATAAATGTG

>14220_14220_5_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000339882_IDH1_chr2_209104729_ENST00000415913_length(amino acids)=204AA_BP=73
MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD

--------------------------------------------------------------
>14220_14220_6_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000339882_IDH1_chr2_209104729_ENST00000446179_length(transcript)=1608nt_BP=366nt
GGCGGCGTCTGCTTGCGCGGTGCAGCCCCAGCGTAGCCCGGGGCTGCCGGTGCCGGCCGCGCCATTGTTGGGGGAGGGGGCGGCTGTTGA
GGGCGGCGGAGTAGGGGGCGAGCGAAGGCGGTGGCAGAGAGGAGCGGAGGCTTCCCATGGGGAACACGCTGACCTGTTGCGTGTCCCCCA
ATGCCAGCCCCAAGCTGGGCCGGCGCGCGGGGTCGGCGGAGCTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCCGGGGACGCGGTGG
CGGTAGCGCCCGCTGTGGTGGAGCCTGCCGAGTTGGATTTCGGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGCGACCGCGAGATGC
CCGAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTGGTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCTGCCCACGGGACTG
TAACCCGTCACTACCGCATGTACCAGAAAGGACAGGAGACGTCCACCAATCCCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTAGCCC
ACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTTGCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATTGAGGCTGGCTTCA
TGACCAAGGACTTGGCTGCTTGCATTAAAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAACTTG
GAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAAGTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTGGTAACTAGGTCTA
CAGGTTTACATTTTTCTGTGTTACACTCAAGGATAAAGGCAAAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTTATCTTTTCTATAA
GTTTACAGCCTTTTTCTTATATATACAGTTATTGCCACCTTTGTGAACATGGCAAGGGACTTTTTTACAATTTTTATTTTATTTTCTAGT
ACCAGCCTAGGAATTCGGTTAGTACTCATTTGTATTCACTGTCACTTTTTCTCATGTTCTAATTATAAATGACCAAAATCAAGATTGCTC
AAAAGGGTAAATGATAGCCACAGTATTGCTCCCTAAAATATGCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTCCATGACCTTGGGC
ACAGGGAAGTTCTGGTGTCATAGATATCCCGTTTTGTGAGGTAGAGCTGTGCATTAAACTTGCACATGACTGGAACGAAGTAGGAGTGCA
ACTCAAATGTGTTGAAGATACTGCAGTCATTTTTGTAAAGACCTTGCTGAATGTTTCCAATAGACTAAATACTGTTTAGGCCGCAGGAGA
GTTTGGAATCCGGAATAAATACTACCTGGAGGTTTGTCCTCTCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAATATTATACTACTC
TAAATAGCATATTTCATCCAAGTGCAATAATGTAAGCTGAATCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTTTTATATAAATGTG

>14220_14220_6_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000339882_IDH1_chr2_209104729_ENST00000446179_length(amino acids)=204AA_BP=73
MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD

--------------------------------------------------------------
>14220_14220_7_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000392209_IDH1_chr2_209104729_ENST00000345146_length(transcript)=1572nt_BP=325nt
GAGGAGCTCCAGCCGCGCTCTCTCCCGGCAGTGGCTGTGCTTCACAGCGCTTGTTGGGTTCCCCACCCCTTTTAAATAAGCCGGGCTGGT
CACCGCCCTCGCAGACGAGTCAGCTTAAGGGAGGCGGCGGCAGCGCGGCGGTGGGGCCCCAAGCTGGGCCGGCGCGCGGGGTCGGCGGAG
CTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCCGGGGACGCGGTGGCGGTAGCGCCCGCTGTGGTGGAGCCTGCCGAGTTGGATTTC
GGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGCGACCGCGAGATGCCCGAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTG
GTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCCGTCACTACCGCATGTACCAGAAAGGACAGGAGACG
TCCACCAATCCCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTAGCCCACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTT
GCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATTGAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCATTAAAGGTTTACCCAAT
GTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAACTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAA
GTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTGGTAACTAGGTCTACAGGTTTACATTTTTCTGTGTTACACTCAAGGATAAAGGCA
AAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTTATCTTTTCTATAAGTTTACAGCCTTTTTCTTATATATACAGTTATTGCCACCTT
TGTGAACATGGCAAGGGACTTTTTTACAATTTTTATTTTATTTTCTAGTACCAGCCTAGGAATTCGGTTAGTACTCATTTGTATTCACTG
TCACTTTTTCTCATGTTCTAATTATAAATGACCAAAATCAAGATTGCTCAAAAGGGTAAATGATAGCCACAGTATTGCTCCCTAAAATAT
GCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTCCATGACCTTGGGCACAGGGAAGTTCTGGTGTCATAGATATCCCGTTTTGTGAGG
TAGAGCTGTGCATTAAACTTGCACATGACTGGAACGAAGTAGGAGTGCAACTCAAATGTGTTGAAGATACTGCAGTCATTTTTGTAAAGA
CCTTGCTGAATGTTTCCAATAGACTAAATACTGTTTAGGCCGCAGGAGAGTTTGGAATCCGGAATAAATACTACCTGGAGGTTTGTCCTC
TCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAATATTATACTACTCTAAATAGCATATTTCATCCAAGTGCAATAATGTAAGCTGAA
TCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTTTTATATAAATGTGATTTCTCAGAAATTGATATTAAACACTATCTTATCTTCTCC

>14220_14220_7_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000392209_IDH1_chr2_209104729_ENST00000345146_length(amino acids)=188AA_BP=57
MGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHY
RMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLK

--------------------------------------------------------------
>14220_14220_8_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000392209_IDH1_chr2_209104729_ENST00000415913_length(transcript)=1534nt_BP=325nt
GAGGAGCTCCAGCCGCGCTCTCTCCCGGCAGTGGCTGTGCTTCACAGCGCTTGTTGGGTTCCCCACCCCTTTTAAATAAGCCGGGCTGGT
CACCGCCCTCGCAGACGAGTCAGCTTAAGGGAGGCGGCGGCAGCGCGGCGGTGGGGCCCCAAGCTGGGCCGGCGCGCGGGGTCGGCGGAG
CTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCCGGGGACGCGGTGGCGGTAGCGCCCGCTGTGGTGGAGCCTGCCGAGTTGGATTTC
GGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGCGACCGCGAGATGCCCGAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTG
GTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCCGTCACTACCGCATGTACCAGAAAGGACAGGAGACG
TCCACCAATCCCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTAGCCCACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTT
GCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATTGAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCATTAAAGGTTTACCCAAT
GTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAACTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAA
GTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTGGTAACTAGGTCTACAGGTTTACATTTTTCTGTGTTACACTCAAGGATAAAGGCA
AAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTTATCTTTTCTATAAGTTTACAGCCTTTTTCTTATATATACAGTTATTGCCACCTT
TGTGAACATGGCAAGGGACTTTTTTACAATTTTTATTTTATTTTCTAGTACCAGCCTAGGAATTCGGTTAGTACTCATTTGTATTCACTG
TCACTTTTTCTCATGTTCTAATTATAAATGACCAAAATCAAGATTGCTCAAAAGGGTAAATGATAGCCACAGTATTGCTCCCTAAAATAT
GCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTCCATGACCTTGGGCACAGGGAAGTTCTGGTGTCATAGATATCCCGTTTTGTGAGG
TAGAGCTGTGCATTAAACTTGCACATGACTGGAACGAAGTAGGAGTGCAACTCAAATGTGTTGAAGATACTGCAGTCATTTTTGTAAAGA
CCTTGCTGAATGTTTCCAATAGACTAAATACTGTTTAGGCCGCAGGAGAGTTTGGAATCCGGAATAAATACTACCTGGAGGTTTGTCCTC
TCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAATATTATACTACTCTAAATAGCATATTTCATCCAAGTGCAATAATGTAAGCTGAA
TCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTTTTATATAAATGTGATTTCTCAGAAATTGATATTAAACACTATCTTATCTTCTCC

>14220_14220_8_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000392209_IDH1_chr2_209104729_ENST00000415913_length(amino acids)=188AA_BP=57
MGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHY
RMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLK

--------------------------------------------------------------
>14220_14220_9_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000392209_IDH1_chr2_209104729_ENST00000446179_length(transcript)=1567nt_BP=325nt
GAGGAGCTCCAGCCGCGCTCTCTCCCGGCAGTGGCTGTGCTTCACAGCGCTTGTTGGGTTCCCCACCCCTTTTAAATAAGCCGGGCTGGT
CACCGCCCTCGCAGACGAGTCAGCTTAAGGGAGGCGGCGGCAGCGCGGCGGTGGGGCCCCAAGCTGGGCCGGCGCGCGGGGTCGGCGGAG
CTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCCGGGGACGCGGTGGCGGTAGCGCCCGCTGTGGTGGAGCCTGCCGAGTTGGATTTC
GGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGCGACCGCGAGATGCCCGAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTG
GTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCCGTCACTACCGCATGTACCAGAAAGGACAGGAGACG
TCCACCAATCCCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTAGCCCACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTT
GCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATTGAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCATTAAAGGTTTACCCAAT
GTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAACTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAA
GTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTGGTAACTAGGTCTACAGGTTTACATTTTTCTGTGTTACACTCAAGGATAAAGGCA
AAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTTATCTTTTCTATAAGTTTACAGCCTTTTTCTTATATATACAGTTATTGCCACCTT
TGTGAACATGGCAAGGGACTTTTTTACAATTTTTATTTTATTTTCTAGTACCAGCCTAGGAATTCGGTTAGTACTCATTTGTATTCACTG
TCACTTTTTCTCATGTTCTAATTATAAATGACCAAAATCAAGATTGCTCAAAAGGGTAAATGATAGCCACAGTATTGCTCCCTAAAATAT
GCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTCCATGACCTTGGGCACAGGGAAGTTCTGGTGTCATAGATATCCCGTTTTGTGAGG
TAGAGCTGTGCATTAAACTTGCACATGACTGGAACGAAGTAGGAGTGCAACTCAAATGTGTTGAAGATACTGCAGTCATTTTTGTAAAGA
CCTTGCTGAATGTTTCCAATAGACTAAATACTGTTTAGGCCGCAGGAGAGTTTGGAATCCGGAATAAATACTACCTGGAGGTTTGTCCTC
TCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAATATTATACTACTCTAAATAGCATATTTCATCCAAGTGCAATAATGTAAGCTGAA
TCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTTTTATATAAATGTGATTTCTCAGAAATTGATATTAAACACTATCTTATCTTCTCC

>14220_14220_9_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000392209_IDH1_chr2_209104729_ENST00000446179_length(amino acids)=188AA_BP=57
MGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHY
RMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLK

--------------------------------------------------------------
>14220_14220_10_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000420822_IDH1_chr2_209104729_ENST00000345146_length(transcript)=1716nt_BP=469nt
GTCAGCTTAAGGGAGGCGGCGGCAGCGCGGCGGTGGGGGTGCGGCCGAGGCCCGAGCCCTGCCCGGGGCCGGGCCGCGGGGCGGGCGGGC
GAACCGCGGGCGAGGCGGCGTCTGCTTGCGCGGTGCAGCCCCAGCGTAGCCCGGGGCTGCCGGTGCCGGCCGCGCCATTGTTGGGGGAGG
GGGCGGCTGTTGAGGGCGGCGGAGTAGGGGGCGAGCGAAGGCGGTGGCAGAGAGGAGCGGAGGCTTCCCATGGGGAACACGCTGACCTGT
TGCGTGTCCCCCAATGCCAGCCCCAAGCTGGGCCGGCGCGCGGGGTCGGCGGAGCTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCC
GGGGACGCGGTGGCGGTAGCGCCCGCTGTGGTGGAGCCTGCCGAGTTGGATTTCGGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGC
GACCGCGAGATGCCCGAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTGGTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCT
GCCCACGGGACTGTAACCCGTCACTACCGCATGTACCAGAAAGGACAGGAGACGTCCACCAATCCCATTGCTTCCATTTTTGCCTGGACC
AGAGGGTTAGCCCACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTTGCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATT
GAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCATTAAAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTC
ATGGATAAACTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAAGTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTG
GTAACTAGGTCTACAGGTTTACATTTTTCTGTGTTACACTCAAGGATAAAGGCAAAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTT
ATCTTTTCTATAAGTTTACAGCCTTTTTCTTATATATACAGTTATTGCCACCTTTGTGAACATGGCAAGGGACTTTTTTACAATTTTTAT
TTTATTTTCTAGTACCAGCCTAGGAATTCGGTTAGTACTCATTTGTATTCACTGTCACTTTTTCTCATGTTCTAATTATAAATGACCAAA
ATCAAGATTGCTCAAAAGGGTAAATGATAGCCACAGTATTGCTCCCTAAAATATGCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTC
CATGACCTTGGGCACAGGGAAGTTCTGGTGTCATAGATATCCCGTTTTGTGAGGTAGAGCTGTGCATTAAACTTGCACATGACTGGAACG
AAGTAGGAGTGCAACTCAAATGTGTTGAAGATACTGCAGTCATTTTTGTAAAGACCTTGCTGAATGTTTCCAATAGACTAAATACTGTTT
AGGCCGCAGGAGAGTTTGGAATCCGGAATAAATACTACCTGGAGGTTTGTCCTCTCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAA
TATTATACTACTCTAAATAGCATATTTCATCCAAGTGCAATAATGTAAGCTGAATCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTT
TTATATAAATGTGATTTCTCAGAAATTGATATTAAACACTATCTTATCTTCTCCTGAACTGTTGATTTTAATTAAAATTAAGTGCTAATT

>14220_14220_10_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000420822_IDH1_chr2_209104729_ENST00000345146_length(amino acids)=204AA_BP=73
MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD

--------------------------------------------------------------
>14220_14220_11_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000420822_IDH1_chr2_209104729_ENST00000415913_length(transcript)=1678nt_BP=469nt
GTCAGCTTAAGGGAGGCGGCGGCAGCGCGGCGGTGGGGGTGCGGCCGAGGCCCGAGCCCTGCCCGGGGCCGGGCCGCGGGGCGGGCGGGC
GAACCGCGGGCGAGGCGGCGTCTGCTTGCGCGGTGCAGCCCCAGCGTAGCCCGGGGCTGCCGGTGCCGGCCGCGCCATTGTTGGGGGAGG
GGGCGGCTGTTGAGGGCGGCGGAGTAGGGGGCGAGCGAAGGCGGTGGCAGAGAGGAGCGGAGGCTTCCCATGGGGAACACGCTGACCTGT
TGCGTGTCCCCCAATGCCAGCCCCAAGCTGGGCCGGCGCGCGGGGTCGGCGGAGCTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCC
GGGGACGCGGTGGCGGTAGCGCCCGCTGTGGTGGAGCCTGCCGAGTTGGATTTCGGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGC
GACCGCGAGATGCCCGAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTGGTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCT
GCCCACGGGACTGTAACCCGTCACTACCGCATGTACCAGAAAGGACAGGAGACGTCCACCAATCCCATTGCTTCCATTTTTGCCTGGACC
AGAGGGTTAGCCCACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTTGCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATT
GAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCATTAAAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTC
ATGGATAAACTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAAGTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTG
GTAACTAGGTCTACAGGTTTACATTTTTCTGTGTTACACTCAAGGATAAAGGCAAAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTT
ATCTTTTCTATAAGTTTACAGCCTTTTTCTTATATATACAGTTATTGCCACCTTTGTGAACATGGCAAGGGACTTTTTTACAATTTTTAT
TTTATTTTCTAGTACCAGCCTAGGAATTCGGTTAGTACTCATTTGTATTCACTGTCACTTTTTCTCATGTTCTAATTATAAATGACCAAA
ATCAAGATTGCTCAAAAGGGTAAATGATAGCCACAGTATTGCTCCCTAAAATATGCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTC
CATGACCTTGGGCACAGGGAAGTTCTGGTGTCATAGATATCCCGTTTTGTGAGGTAGAGCTGTGCATTAAACTTGCACATGACTGGAACG
AAGTAGGAGTGCAACTCAAATGTGTTGAAGATACTGCAGTCATTTTTGTAAAGACCTTGCTGAATGTTTCCAATAGACTAAATACTGTTT
AGGCCGCAGGAGAGTTTGGAATCCGGAATAAATACTACCTGGAGGTTTGTCCTCTCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAA
TATTATACTACTCTAAATAGCATATTTCATCCAAGTGCAATAATGTAAGCTGAATCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTT

>14220_14220_11_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000420822_IDH1_chr2_209104729_ENST00000415913_length(amino acids)=204AA_BP=73
MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD

--------------------------------------------------------------
>14220_14220_12_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000420822_IDH1_chr2_209104729_ENST00000446179_length(transcript)=1711nt_BP=469nt
GTCAGCTTAAGGGAGGCGGCGGCAGCGCGGCGGTGGGGGTGCGGCCGAGGCCCGAGCCCTGCCCGGGGCCGGGCCGCGGGGCGGGCGGGC
GAACCGCGGGCGAGGCGGCGTCTGCTTGCGCGGTGCAGCCCCAGCGTAGCCCGGGGCTGCCGGTGCCGGCCGCGCCATTGTTGGGGGAGG
GGGCGGCTGTTGAGGGCGGCGGAGTAGGGGGCGAGCGAAGGCGGTGGCAGAGAGGAGCGGAGGCTTCCCATGGGGAACACGCTGACCTGT
TGCGTGTCCCCCAATGCCAGCCCCAAGCTGGGCCGGCGCGCGGGGTCGGCGGAGCTGTACTGCGCGTCCGACATCTACGAGGCGGTGTCC
GGGGACGCGGTGGCGGTAGCGCCCGCTGTGGTGGAGCCTGCCGAGTTGGATTTCGGAGAGGGCGAGGGCCACCACCTGCAGCACATCAGC
GACCGCGAGATGCCCGAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTGGTTTGTCCAGATGGCAAGACAGTAGAAGCAGAGGCT
GCCCACGGGACTGTAACCCGTCACTACCGCATGTACCAGAAAGGACAGGAGACGTCCACCAATCCCATTGCTTCCATTTTTGCCTGGACC
AGAGGGTTAGCCCACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTTGCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATT
GAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCATTAAAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTC
ATGGATAAACTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAAGTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTG
GTAACTAGGTCTACAGGTTTACATTTTTCTGTGTTACACTCAAGGATAAAGGCAAAATCAATTTTGTAATTTGTTTAGAAGCCAGAGTTT
ATCTTTTCTATAAGTTTACAGCCTTTTTCTTATATATACAGTTATTGCCACCTTTGTGAACATGGCAAGGGACTTTTTTACAATTTTTAT
TTTATTTTCTAGTACCAGCCTAGGAATTCGGTTAGTACTCATTTGTATTCACTGTCACTTTTTCTCATGTTCTAATTATAAATGACCAAA
ATCAAGATTGCTCAAAAGGGTAAATGATAGCCACAGTATTGCTCCCTAAAATATGCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTC
CATGACCTTGGGCACAGGGAAGTTCTGGTGTCATAGATATCCCGTTTTGTGAGGTAGAGCTGTGCATTAAACTTGCACATGACTGGAACG
AAGTAGGAGTGCAACTCAAATGTGTTGAAGATACTGCAGTCATTTTTGTAAAGACCTTGCTGAATGTTTCCAATAGACTAAATACTGTTT
AGGCCGCAGGAGAGTTTGGAATCCGGAATAAATACTACCTGGAGGTTTGTCCTCTCCATTTTTCTCTTTCTCCTCCTGGCCTGGCCTGAA
TATTATACTACTCTAAATAGCATATTTCATCCAAGTGCAATAATGTAAGCTGAATCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTT
TTATATAAATGTGATTTCTCAGAAATTGATATTAAACACTATCTTATCTTCTCCTGAACTGTTGATTTTAATTAAAATTAAGTGCTAATT

>14220_14220_12_CCNYL1-IDH1_CCNYL1_chr2_208576841_ENST00000420822_IDH1_chr2_209104729_ENST00000446179_length(amino acids)=204AA_BP=73
MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD

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Fusion Gene PPI Analysis for CCNYL1-IDH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCNYL1-IDH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCNYL1-IDH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource