FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CCT3-ARHGEF11 (FusionGDB2 ID:14293)

Fusion Gene Summary for CCT3-ARHGEF11

check button Fusion gene summary
Fusion gene informationFusion gene name: CCT3-ARHGEF11
Fusion gene ID: 14293
HgeneTgene
Gene symbol

CCT3

ARHGEF11

Gene ID

7203

9826

Gene namechaperonin containing TCP1 subunit 3Rho guanine nucleotide exchange factor 11
SynonymsCCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5GTRAP48|PDZ-RHOGEF
Cytomap

1q22

1q23.1

Type of geneprotein-codingprotein-coding
DescriptionT-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5rho guanine nucleotide exchange factor 11Rho guanine exchange factor (GEF) 11Rho guanine nucleotide exchange factor (GEF) 11RhoA-specific guanine nucleotide exchange factorRhoGEF glutamate transport modulatorglutamate transporter EAAT4-associated pro
Modification date2020032720200313
UniProtAcc

P49368

O15085

Ensembl transtripts involved in fusion geneENST00000295688, ENST00000368261, 
ENST00000472765, ENST00000368256, 
ENST00000368259, 		ENST00000315174, 
ENST00000361409, ENST00000487682, 
ENST00000368194, 
Fusion gene scores* DoF score24 X 18 X 12=51846 X 6 X 5=180
# samples 287
** MAII scorelog2(28/5184*10)=-4.21056698593966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCT3 [Title/Abstract] AND ARHGEF11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCT3(156304504)-ARHGEF11(156931567), # samples:3
Anticipated loss of major functional domain due to fusion event.CCT3-ARHGEF11 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CCT3-ARHGEF11 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CCT3-ARHGEF11 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARHGEF11

GO:0007186

G protein-coupled receptor signaling pathway

15755723

TgeneARHGEF11

GO:0007266

Rho protein signal transduction

10026210

TgeneARHGEF11

GO:0045893

positive regulation of transcription, DNA-templated

10026210


check buttonFusion gene breakpoints across CCT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGEF11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-A5FT-01ACCT3chr1

156304504

-ARHGEF11chr1

156931567

-
ChimerDB4OVTCGA-13-A5FTCCT3chr1

156304503

-ARHGEF11chr1

156931567

-


Top

Fusion Gene ORF analysis for CCT3-ARHGEF11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000295688ENST00000315174CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000295688ENST00000315174CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000295688ENST00000361409CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000295688ENST00000361409CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000295688ENST00000487682CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000295688ENST00000487682CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000368261ENST00000315174CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000368261ENST00000315174CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000368261ENST00000361409CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000368261ENST00000361409CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000368261ENST00000487682CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000368261ENST00000487682CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000472765ENST00000315174CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000472765ENST00000315174CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000472765ENST00000361409CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000472765ENST00000361409CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000472765ENST00000487682CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5CDS-intronENST00000472765ENST00000487682CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5UTR-3CDSENST00000368256ENST00000368194CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5UTR-3CDSENST00000368256ENST00000368194CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5UTR-intronENST00000368256ENST00000315174CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5UTR-intronENST00000368256ENST00000315174CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5UTR-intronENST00000368256ENST00000361409CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5UTR-intronENST00000368256ENST00000361409CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
5UTR-intronENST00000368256ENST00000487682CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
5UTR-intronENST00000368256ENST00000487682CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
Frame-shiftENST00000368261ENST00000368194CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
Frame-shiftENST00000368261ENST00000368194CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
In-frameENST00000295688ENST00000368194CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
In-frameENST00000295688ENST00000368194CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
In-frameENST00000472765ENST00000368194CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
In-frameENST00000472765ENST00000368194CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
intron-3CDSENST00000368259ENST00000368194CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
intron-3CDSENST00000368259ENST00000368194CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
intron-intronENST00000368259ENST00000315174CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
intron-intronENST00000368259ENST00000315174CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
intron-intronENST00000368259ENST00000361409CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
intron-intronENST00000368259ENST00000361409CCT3chr1

156304503

-ARHGEF11chr1

156931567

-
intron-intronENST00000368259ENST00000487682CCT3chr1

156304504

-ARHGEF11chr1

156931567

-
intron-intronENST00000368259ENST00000487682CCT3chr1

156304503

-ARHGEF11chr1

156931567

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295688CCT3chr1156304504-ENST00000368194ARHGEF11chr1156931567-519748820640361276
ENST00000472765CCT3chr1156304504-ENST00000368194ARHGEF11chr1156931567-510239330639411211
ENST00000295688CCT3chr1156304503-ENST00000368194ARHGEF11chr1156931567-519748820640361276
ENST00000472765CCT3chr1156304503-ENST00000368194ARHGEF11chr1156931567-510239330639411211

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295688ENST00000368194CCT3chr1156304504-ARHGEF11chr1156931567-0.0020288090.99797124
ENST00000472765ENST00000368194CCT3chr1156304504-ARHGEF11chr1156931567-0.0021760610.99782395
ENST00000295688ENST00000368194CCT3chr1156304503-ARHGEF11chr1156931567-0.0020288090.99797124
ENST00000472765ENST00000368194CCT3chr1156304503-ARHGEF11chr1156931567-0.0021760610.99782395

Top

Fusion Genomic Features for CCT3-ARHGEF11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CCT3-ARHGEF11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:156304504/chr1:156931567)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCT3

P49368

ARHGEF11

O15085

FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.FUNCTION: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGEF11chr1:156304503chr1:156931567ENST000003614091140444_4703401523.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF11chr1:156304503chr1:156931567ENST000003681941241444_4703801563.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF11chr1:156304504chr1:156931567ENST000003614091140444_4703401523.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF11chr1:156304504chr1:156931567ENST000003681941241444_4703801563.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF11chr1:156304503chr1:156931567ENST0000036140911401094_10993401523.0Compositional biasNote=Poly-Pro
TgeneARHGEF11chr1:156304503chr1:156931567ENST0000036819412411094_10993801563.0Compositional biasNote=Poly-Pro
TgeneARHGEF11chr1:156304504chr1:156931567ENST0000036140911401094_10993401523.0Compositional biasNote=Poly-Pro
TgeneARHGEF11chr1:156304504chr1:156931567ENST0000036819412411094_10993801563.0Compositional biasNote=Poly-Pro
TgeneARHGEF11chr1:156304503chr1:156931567ENST000003614091140734_9233401523.0DomainDH
TgeneARHGEF11chr1:156304503chr1:156931567ENST000003614091140965_10793401523.0DomainPH
TgeneARHGEF11chr1:156304503chr1:156931567ENST000003681941241734_9233801563.0DomainDH
TgeneARHGEF11chr1:156304503chr1:156931567ENST000003681941241965_10793801563.0DomainPH
TgeneARHGEF11chr1:156304504chr1:156931567ENST000003614091140734_9233401523.0DomainDH
TgeneARHGEF11chr1:156304504chr1:156931567ENST000003614091140965_10793401523.0DomainPH
TgeneARHGEF11chr1:156304504chr1:156931567ENST000003681941241734_9233801563.0DomainDH
TgeneARHGEF11chr1:156304504chr1:156931567ENST000003681941241965_10793801563.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGEF11chr1:156304503chr1:156931567ENST000003614091140306_4863401523.0DomainRGSL
TgeneARHGEF11chr1:156304503chr1:156931567ENST00000361409114047_1263401523.0DomainPDZ
TgeneARHGEF11chr1:156304503chr1:156931567ENST000003681941241306_4863801563.0DomainRGSL
TgeneARHGEF11chr1:156304503chr1:156931567ENST00000368194124147_1263801563.0DomainPDZ
TgeneARHGEF11chr1:156304504chr1:156931567ENST000003614091140306_4863401523.0DomainRGSL
TgeneARHGEF11chr1:156304504chr1:156931567ENST00000361409114047_1263401523.0DomainPDZ
TgeneARHGEF11chr1:156304504chr1:156931567ENST000003681941241306_4863801563.0DomainRGSL
TgeneARHGEF11chr1:156304504chr1:156931567ENST00000368194124147_1263801563.0DomainPDZ


Top

Fusion Gene Sequence for CCT3-ARHGEF11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14293_14293_1_CCT3-ARHGEF11_CCT3_chr1_156304503_ENST00000295688_ARHGEF11_chr1_156931567_ENST00000368194_length(transcript)=5197nt_BP=488nt
ACTGCGCAAGCGCCTGTGCCCTCCCAGTGCCTTCGTCGTGCGCTCTCTGTCTAACTTGTCTGGCCGTTCTTGCGTAGGGGGCGGGACTAA
GGCTGTCAATTGGTCTGTTTTTGTGCCGATCAATGAGATGGGTGCGGTGATTGGCGACTACCTTGAGAGTAGCGGGTTGAGGTGTAAGCC
CTGAGGAGGCAGCGTTTTCTGGGCTTCTGTCTGGTTCTCTCTCTCCAGAAGGTTCTGCCGGTTCCCCCAGCTCTGGGTACCCGGCTCTGC
ATCGCGTCGCCATGATGGGCCATCGTCCAGTGCTCGTGCTCAGCCAGAACACAAAGCGTGAATCCGGAAGAAAAGTTCAATCTGGAAACA
TCAATGCTGCCAAGACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCA
TTGTGATGACCAATGATGGCAATGCCATTCTTCGAGAGCTTTTTTACCTGTGTGCAGAAGTTTATCAGCAGGCAAGCCCCAAGGATTCCC
GAAGCTTGGGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCTGAGATGCTACAGGCTGAAATTG
ACTCGCGCCTGCGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAGAGCAGATCCACG
ACTACAGAACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGATGGGGACCCTCTCCGAGAGCGCC
AAGTGGCTGAGAAGCAGCTGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATA
CCTACATGAGCCATGCTGGGATCCGTCTTCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGT
GGCTACCGTTCTTCCCTAAGACCAAGAAGAGCAGCAATTCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCA
AATACATTGGGAAGCCCAAAAGCTCTTCTCAAAGCACATTTCATATTCCCTTGTCCCCTGTGGAAGTCAAACCAGGCAATGTGAGGAACA
TCATTCAGCACTTTGAGAACAACCAGCAGTATGATGCCCCAGAACCTGGGACACAACGACTCTCGACCGGAAGCTTTCCTGAGGACCTGC
TGGAGAGTGACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAAGCCTCAAGGGCCGGGAAGAGATGAAACGGTCTCGAAAGGCAG
AGAACGTGCCCCGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACTCGCCTGCACCAGTCAGCCTCGTCCTCTACCTCCA
GCCTCTCCACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATTGAGTCCCCCAGTTTGGGGTTCT
GCACAGATACCCTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCCAAAATTGGCAGC
ATACAGTGGGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAATGAGCTGTTTGTGACTGAAGCTT
CCCACCTGCGCACACTCCGGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGC
TCTTCCCGAACCTGCCTGAACTCATAGAGATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAG
AGATCAGTGACCTCATGCTGGCCCGGTTTGATGGCCCTGCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAA
TAGCCCTAGAGCTAATCAAGACCAAGCAACGCAAGGAGAGTCGATTCCAGCTCTTCATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGC
GGCTGCAGCTGAGAGACCTCATCATCTCTGAGATGCAGCGGCTCACCAAGTACCCGCTGCTGCTGGAGAGCATCATCAAGCACACAGAGG
GTGGCACCTCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCCGGGAGATTCTCAAGTATGTGAATGAAGCGGTAAAACAAACAG
AGAACCGCCACCGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAGAGGGCCAGCAACCCCCTGGCAGCAGAGTTCAAGA
GCCTGGATCTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAGACCTTGGACCTCCACGTGCTGC
TGCTGGAGGACCTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGGGCTCCTCAGACA
GCAAGCAGACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAACGGGCCTTCTTCATCATCTGCA
CCTCCAAGCTGGGCCCACCCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCG
TGCGGAATGCCACCAGGCACCCCGGAGCTGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCA
CACCCAGCAGGGTAGAACTGGATGACTCAGACGTGTTCCATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGA
GGGTCCAAGGGAAGCACCAGGTCCTGCTAGAGGACCCTGAGCAGGAGGGCAGTGCAGAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTT
CCACATCCCTGGATGGAGAGAACAGGGGCATCAGGACAAGGAACCCCATCCACTTGGCCTTCCCAGGCCCTCTGTTCATGGAAGGGCTCG
CTGACTCCGCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGTGGAGCCTGCTGCCAGGTCACACCATGGAAACTCAGGCTGCCC
AGGAGCCCGAGGACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCACCCCTGGGACCCAGGCTCCCCAGGGCAAGCACCCC
CTGGGGGTGAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATGGGTCTCTGTTCTCTGGAACACC
TACCCCCAAGGACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCACAGAGGCAGCAG
GAGGTTACAAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGTGGCCAGTCAGAGCCTGGGCCAC
CTGAAGTGGAAGGCGGAACAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAG
AGGCACCCATGAGCCCCCCTCAGCCTGACAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTGCAGGGAGGCAACGATGATCCAA
GACGCCCCAGCCGCTCTCCTCCAAGCCTGGCCCTCAGGGACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACA
GGCTCAAGGATATGGAGCTGGCCCACAGAGAGCTGCTCAAGTCCCTTGGGGGAGAGTCATCTGGTGGCACCACGCCTGTGGGCAGTTTCC
ACACAGAAGCAGCTAGATGGACAGATGGCTCCCTCTCACCTCCCGCTAAGGAGCCCCTAGCTTCTGACTCCAGGAACAGCCATGAACTGG
GGCCCTGCCCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAGCAGACGCAGCCGCGTCACCAGGACCATAACCGTACAAACCAC
CAAATCCTCTGCGTCCCCACTCCTCCTTCAGGGACTGGCCTGAGACCGGGGCACAGGGTAGGGGGGATCCCAACACTCCTCCCTGTGGAG
GAGGCAGTTAGGGAAACTAGGATCCAGCCAAGGCCCGGGGGGAGACCCGCATGTTGCTTGGTCTGCTCAAGTCGGAGTCAGGTTTCAGTG
TCTTTTCCCTCCCTTAGCCCAACCCTCCAAGGCCTCATGTCTCCTAAGCATGCTGACTGCATCCGAAAGGCCCCCACTCACCATGGTCTG
CCCTCACCCCACATATGTGTGTACACGCGCACGCCTGTATGTGCGCTGCCCTCAGACATGCAAGTGAAAGGAGGAGGCTTCTGTGTAAAT
GCACTTTCTTCCTCCCCTCTTTCTCCATAAGACCCCAGGCAGAGGTGGGTGCCTCCCCTCCCCTCTTTGTCACTTTGGTTTCCTATAAAT
ATGTATGTATCGTATGTGCATCTTTGCTATTGTAAATAACTTTGACCTTTTTTGTTCCTGTTCCTGAAGTGCTGGAGGCAGTTATGGAAG
GAGCTGCTTAGGGAAGAGGGGTTTCACTTGTATCTCCTTAGTTAACAACCCAGTTCCAGGATCGAGCCTAAAGCGGGAGCCAGGCCTGAG
TGTTCCTGTCCCTGTGAGTGGGAAGGTCTTCTGGCTCCCCATCCCACCTGGCTCCAGAGCCTGCCCTCCACAGCTTGCTGCCAAGCTACT
CCCTCCCTCCCTGGACTTCTCATCTTCACAAGATGGGGATCATGGGGGTTTCTTACCCCACCTATGTCCCCCTCTTCCCCACCCTGTCCC
TGTAGAAAACCAGTGAAGCAGGTACGGAGCTGAGGACTGGGCCCCAGGAGGTGGGGACAGGGGTCTGAATGCCGAGTCCCTGAATTCACC
CAGGACCATCCAAGGGGCCACCGCAGCATTGGCCCCATCACCACGTCCTCACCCAACTCTCCCTGATGAATAGAATATACACACTGTGCT
AGGTGTATATATACATATATATATATATAAATATATATATAATATATAAAATATAGATATGGAAATGACTGTTCTGCTGTTAAGATAATG

>14293_14293_1_CCT3-ARHGEF11_CCT3_chr1_156304503_ENST00000295688_ARHGEF11_chr1_156931567_ENST00000368194_length(amino acids)=1276AA_BP=94
MSGSLSPEGSAGSPSSGYPALHRVAMMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNA
ILRELFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLG
LGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTK
KSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSE
IRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHL
LEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELI
EIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLII
SEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKM
IHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQI
YELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVL
LEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTP
TPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKA
EVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPS
LALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSD

--------------------------------------------------------------
>14293_14293_2_CCT3-ARHGEF11_CCT3_chr1_156304503_ENST00000472765_ARHGEF11_chr1_156931567_ENST00000368194_length(transcript)=5102nt_BP=393nt
GTCTGGTTCTCTCTCTCCAGAAGGTTCTGCCGGTTCCCCCAGCTCTGGGTACCCGGCTCTGCATCGCGTCGCCATGATGGGCCATCGTCC
AGTGCTCGTGCTCATTAGGTCTAGCTTTATATTCTTGGCCCATCCCTTAGTAGCGGTAATTTAAATGTTTCAATCTGTATTACGGAGTTA
ACAGTATTTCCTAGTAGAATTGTGAGAATTAAATGAGGCCAGAACACAAAGCGTGAATCCGGAAGAAAAGTTCAATCTGGAAACATCAAT
GCTGCCAAGACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTG
ATGACCAATGATGGCAATGCCATTCTTCGAGAGCTTTTTTACCTGTGTGCAGAAGTTTATCAGCAGGCAAGCCCCAAGGATTCCCGAAGC
TTGGGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCTGAGATGCTACAGGCTGAAATTGACTCG
CGCCTGCGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAGAGCAGATCCACGACTAC
AGAACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGATGGGGACCCTCTCCGAGAGCGCCAAGTG
GCTGAGAAGCAGCTGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATACCTAC
ATGAGCCATGCTGGGATCCGTCTTCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGTGGCTA
CCGTTCTTCCCTAAGACCAAGAAGAGCAGCAATTCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCAAATAC
ATTGGGAAGCCCAAAAGCTCTTCTCAAAGCACATTTCATATTCCCTTGTCCCCTGTGGAAGTCAAACCAGGCAATGTGAGGAACATCATT
CAGCACTTTGAGAACAACCAGCAGTATGATGCCCCAGAACCTGGGACACAACGACTCTCGACCGGAAGCTTTCCTGAGGACCTGCTGGAG
AGTGACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAAGCCTCAAGGGCCGGGAAGAGATGAAACGGTCTCGAAAGGCAGAGAAC
GTGCCCCGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACTCGCCTGCACCAGTCAGCCTCGTCCTCTACCTCCAGCCTC
TCCACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATTGAGTCCCCCAGTTTGGGGTTCTGCACA
GATACCCTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCCAAAATTGGCAGCATACA
GTGGGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAATGAGCTGTTTGTGACTGAAGCTTCCCAC
CTGCGCACACTCCGGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGCTCTTC
CCGAACCTGCCTGAACTCATAGAGATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAGAGATC
AGTGACCTCATGCTGGCCCGGTTTGATGGCCCTGCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAATAGCC
CTAGAGCTAATCAAGACCAAGCAACGCAAGGAGAGTCGATTCCAGCTCTTCATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGCGGCTG
CAGCTGAGAGACCTCATCATCTCTGAGATGCAGCGGCTCACCAAGTACCCGCTGCTGCTGGAGAGCATCATCAAGCACACAGAGGGTGGC
ACCTCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCCGGGAGATTCTCAAGTATGTGAATGAAGCGGTAAAACAAACAGAGAAC
CGCCACCGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAGAGGGCCAGCAACCCCCTGGCAGCAGAGTTCAAGAGCCTG
GATCTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAGACCTTGGACCTCCACGTGCTGCTGCTG
GAGGACCTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGGGCTCCTCAGACAGCAAG
CAGACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAACGGGCCTTCTTCATCATCTGCACCTCC
AAGCTGGGCCCACCCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCGTGCGG
AATGCCACCAGGCACCCCGGAGCTGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCACACCC
AGCAGGGTAGAACTGGATGACTCAGACGTGTTCCATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGAGGGTC
CAAGGGAAGCACCAGGTCCTGCTAGAGGACCCTGAGCAGGAGGGCAGTGCAGAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTTCCACA
TCCCTGGATGGAGAGAACAGGGGCATCAGGACAAGGAACCCCATCCACTTGGCCTTCCCAGGCCCTCTGTTCATGGAAGGGCTCGCTGAC
TCCGCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGTGGAGCCTGCTGCCAGGTCACACCATGGAAACTCAGGCTGCCCAGGAG
CCCGAGGACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCACCCCTGGGACCCAGGCTCCCCAGGGCAAGCACCCCCTGGG
GGTGAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATGGGTCTCTGTTCTCTGGAACACCTACCC
CCAAGGACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCACAGAGGCAGCAGGAGGT
TACAAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGTGGCCAGTCAGAGCCTGGGCCACCTGAA
GTGGAAGGCGGAACAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAGAGGCA
CCCATGAGCCCCCCTCAGCCTGACAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTGCAGGGAGGCAACGATGATCCAAGACGC
CCCAGCCGCTCTCCTCCAAGCCTGGCCCTCAGGGACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACAGGCTC
AAGGATATGGAGCTGGCCCACAGAGAGCTGCTCAAGTCCCTTGGGGGAGAGTCATCTGGTGGCACCACGCCTGTGGGCAGTTTCCACACA
GAAGCAGCTAGATGGACAGATGGCTCCCTCTCACCTCCCGCTAAGGAGCCCCTAGCTTCTGACTCCAGGAACAGCCATGAACTGGGGCCC
TGCCCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAGCAGACGCAGCCGCGTCACCAGGACCATAACCGTACAAACCACCAAAT
CCTCTGCGTCCCCACTCCTCCTTCAGGGACTGGCCTGAGACCGGGGCACAGGGTAGGGGGGATCCCAACACTCCTCCCTGTGGAGGAGGC
AGTTAGGGAAACTAGGATCCAGCCAAGGCCCGGGGGGAGACCCGCATGTTGCTTGGTCTGCTCAAGTCGGAGTCAGGTTTCAGTGTCTTT
TCCCTCCCTTAGCCCAACCCTCCAAGGCCTCATGTCTCCTAAGCATGCTGACTGCATCCGAAAGGCCCCCACTCACCATGGTCTGCCCTC
ACCCCACATATGTGTGTACACGCGCACGCCTGTATGTGCGCTGCCCTCAGACATGCAAGTGAAAGGAGGAGGCTTCTGTGTAAATGCACT
TTCTTCCTCCCCTCTTTCTCCATAAGACCCCAGGCAGAGGTGGGTGCCTCCCCTCCCCTCTTTGTCACTTTGGTTTCCTATAAATATGTA
TGTATCGTATGTGCATCTTTGCTATTGTAAATAACTTTGACCTTTTTTGTTCCTGTTCCTGAAGTGCTGGAGGCAGTTATGGAAGGAGCT
GCTTAGGGAAGAGGGGTTTCACTTGTATCTCCTTAGTTAACAACCCAGTTCCAGGATCGAGCCTAAAGCGGGAGCCAGGCCTGAGTGTTC
CTGTCCCTGTGAGTGGGAAGGTCTTCTGGCTCCCCATCCCACCTGGCTCCAGAGCCTGCCCTCCACAGCTTGCTGCCAAGCTACTCCCTC
CCTCCCTGGACTTCTCATCTTCACAAGATGGGGATCATGGGGGTTTCTTACCCCACCTATGTCCCCCTCTTCCCCACCCTGTCCCTGTAG
AAAACCAGTGAAGCAGGTACGGAGCTGAGGACTGGGCCCCAGGAGGTGGGGACAGGGGTCTGAATGCCGAGTCCCTGAATTCACCCAGGA
CCATCCAAGGGGCCACCGCAGCATTGGCCCCATCACCACGTCCTCACCCAACTCTCCCTGATGAATAGAATATACACACTGTGCTAGGTG
TATATATACATATATATATATATAAATATATATATAATATATAAAATATAGATATGGAAATGACTGTTCTGCTGTTAAGATAATGTATAC

>14293_14293_2_CCT3-ARHGEF11_CCT3_chr1_156304503_ENST00000472765_ARHGEF11_chr1_156931567_ENST00000368194_length(amino acids)=1211AA_BP=29
MGPKSMMKMLLDPMGGIVMTNDGNAILRELFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVL
CEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREAR
PSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAP
EPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPF
TPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFY
QRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKES
RFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLD
ATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAV
LIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFH
GEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHL
ILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESP
ELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPA
GQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSP

--------------------------------------------------------------
>14293_14293_3_CCT3-ARHGEF11_CCT3_chr1_156304504_ENST00000295688_ARHGEF11_chr1_156931567_ENST00000368194_length(transcript)=5197nt_BP=488nt
ACTGCGCAAGCGCCTGTGCCCTCCCAGTGCCTTCGTCGTGCGCTCTCTGTCTAACTTGTCTGGCCGTTCTTGCGTAGGGGGCGGGACTAA
GGCTGTCAATTGGTCTGTTTTTGTGCCGATCAATGAGATGGGTGCGGTGATTGGCGACTACCTTGAGAGTAGCGGGTTGAGGTGTAAGCC
CTGAGGAGGCAGCGTTTTCTGGGCTTCTGTCTGGTTCTCTCTCTCCAGAAGGTTCTGCCGGTTCCCCCAGCTCTGGGTACCCGGCTCTGC
ATCGCGTCGCCATGATGGGCCATCGTCCAGTGCTCGTGCTCAGCCAGAACACAAAGCGTGAATCCGGAAGAAAAGTTCAATCTGGAAACA
TCAATGCTGCCAAGACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCA
TTGTGATGACCAATGATGGCAATGCCATTCTTCGAGAGCTTTTTTACCTGTGTGCAGAAGTTTATCAGCAGGCAAGCCCCAAGGATTCCC
GAAGCTTGGGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCTGAGATGCTACAGGCTGAAATTG
ACTCGCGCCTGCGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAGAGCAGATCCACG
ACTACAGAACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGATGGGGACCCTCTCCGAGAGCGCC
AAGTGGCTGAGAAGCAGCTGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATA
CCTACATGAGCCATGCTGGGATCCGTCTTCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGT
GGCTACCGTTCTTCCCTAAGACCAAGAAGAGCAGCAATTCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCA
AATACATTGGGAAGCCCAAAAGCTCTTCTCAAAGCACATTTCATATTCCCTTGTCCCCTGTGGAAGTCAAACCAGGCAATGTGAGGAACA
TCATTCAGCACTTTGAGAACAACCAGCAGTATGATGCCCCAGAACCTGGGACACAACGACTCTCGACCGGAAGCTTTCCTGAGGACCTGC
TGGAGAGTGACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAAGCCTCAAGGGCCGGGAAGAGATGAAACGGTCTCGAAAGGCAG
AGAACGTGCCCCGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACTCGCCTGCACCAGTCAGCCTCGTCCTCTACCTCCA
GCCTCTCCACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATTGAGTCCCCCAGTTTGGGGTTCT
GCACAGATACCCTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCCAAAATTGGCAGC
ATACAGTGGGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAATGAGCTGTTTGTGACTGAAGCTT
CCCACCTGCGCACACTCCGGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGC
TCTTCCCGAACCTGCCTGAACTCATAGAGATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAG
AGATCAGTGACCTCATGCTGGCCCGGTTTGATGGCCCTGCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAA
TAGCCCTAGAGCTAATCAAGACCAAGCAACGCAAGGAGAGTCGATTCCAGCTCTTCATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGC
GGCTGCAGCTGAGAGACCTCATCATCTCTGAGATGCAGCGGCTCACCAAGTACCCGCTGCTGCTGGAGAGCATCATCAAGCACACAGAGG
GTGGCACCTCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCCGGGAGATTCTCAAGTATGTGAATGAAGCGGTAAAACAAACAG
AGAACCGCCACCGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAGAGGGCCAGCAACCCCCTGGCAGCAGAGTTCAAGA
GCCTGGATCTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAGACCTTGGACCTCCACGTGCTGC
TGCTGGAGGACCTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGGGCTCCTCAGACA
GCAAGCAGACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAACGGGCCTTCTTCATCATCTGCA
CCTCCAAGCTGGGCCCACCCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCG
TGCGGAATGCCACCAGGCACCCCGGAGCTGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCA
CACCCAGCAGGGTAGAACTGGATGACTCAGACGTGTTCCATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGA
GGGTCCAAGGGAAGCACCAGGTCCTGCTAGAGGACCCTGAGCAGGAGGGCAGTGCAGAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTT
CCACATCCCTGGATGGAGAGAACAGGGGCATCAGGACAAGGAACCCCATCCACTTGGCCTTCCCAGGCCCTCTGTTCATGGAAGGGCTCG
CTGACTCCGCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGTGGAGCCTGCTGCCAGGTCACACCATGGAAACTCAGGCTGCCC
AGGAGCCCGAGGACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCACCCCTGGGACCCAGGCTCCCCAGGGCAAGCACCCC
CTGGGGGTGAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATGGGTCTCTGTTCTCTGGAACACC
TACCCCCAAGGACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCACAGAGGCAGCAG
GAGGTTACAAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGTGGCCAGTCAGAGCCTGGGCCAC
CTGAAGTGGAAGGCGGAACAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAG
AGGCACCCATGAGCCCCCCTCAGCCTGACAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTGCAGGGAGGCAACGATGATCCAA
GACGCCCCAGCCGCTCTCCTCCAAGCCTGGCCCTCAGGGACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACA
GGCTCAAGGATATGGAGCTGGCCCACAGAGAGCTGCTCAAGTCCCTTGGGGGAGAGTCATCTGGTGGCACCACGCCTGTGGGCAGTTTCC
ACACAGAAGCAGCTAGATGGACAGATGGCTCCCTCTCACCTCCCGCTAAGGAGCCCCTAGCTTCTGACTCCAGGAACAGCCATGAACTGG
GGCCCTGCCCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAGCAGACGCAGCCGCGTCACCAGGACCATAACCGTACAAACCAC
CAAATCCTCTGCGTCCCCACTCCTCCTTCAGGGACTGGCCTGAGACCGGGGCACAGGGTAGGGGGGATCCCAACACTCCTCCCTGTGGAG
GAGGCAGTTAGGGAAACTAGGATCCAGCCAAGGCCCGGGGGGAGACCCGCATGTTGCTTGGTCTGCTCAAGTCGGAGTCAGGTTTCAGTG
TCTTTTCCCTCCCTTAGCCCAACCCTCCAAGGCCTCATGTCTCCTAAGCATGCTGACTGCATCCGAAAGGCCCCCACTCACCATGGTCTG
CCCTCACCCCACATATGTGTGTACACGCGCACGCCTGTATGTGCGCTGCCCTCAGACATGCAAGTGAAAGGAGGAGGCTTCTGTGTAAAT
GCACTTTCTTCCTCCCCTCTTTCTCCATAAGACCCCAGGCAGAGGTGGGTGCCTCCCCTCCCCTCTTTGTCACTTTGGTTTCCTATAAAT
ATGTATGTATCGTATGTGCATCTTTGCTATTGTAAATAACTTTGACCTTTTTTGTTCCTGTTCCTGAAGTGCTGGAGGCAGTTATGGAAG
GAGCTGCTTAGGGAAGAGGGGTTTCACTTGTATCTCCTTAGTTAACAACCCAGTTCCAGGATCGAGCCTAAAGCGGGAGCCAGGCCTGAG
TGTTCCTGTCCCTGTGAGTGGGAAGGTCTTCTGGCTCCCCATCCCACCTGGCTCCAGAGCCTGCCCTCCACAGCTTGCTGCCAAGCTACT
CCCTCCCTCCCTGGACTTCTCATCTTCACAAGATGGGGATCATGGGGGTTTCTTACCCCACCTATGTCCCCCTCTTCCCCACCCTGTCCC
TGTAGAAAACCAGTGAAGCAGGTACGGAGCTGAGGACTGGGCCCCAGGAGGTGGGGACAGGGGTCTGAATGCCGAGTCCCTGAATTCACC
CAGGACCATCCAAGGGGCCACCGCAGCATTGGCCCCATCACCACGTCCTCACCCAACTCTCCCTGATGAATAGAATATACACACTGTGCT
AGGTGTATATATACATATATATATATATAAATATATATATAATATATAAAATATAGATATGGAAATGACTGTTCTGCTGTTAAGATAATG

>14293_14293_3_CCT3-ARHGEF11_CCT3_chr1_156304504_ENST00000295688_ARHGEF11_chr1_156931567_ENST00000368194_length(amino acids)=1276AA_BP=94
MSGSLSPEGSAGSPSSGYPALHRVAMMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNA
ILRELFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLG
LGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTK
KSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSE
IRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHL
LEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELI
EIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLII
SEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKM
IHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQI
YELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVL
LEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTP
TPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKA
EVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPS
LALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSD

--------------------------------------------------------------
>14293_14293_4_CCT3-ARHGEF11_CCT3_chr1_156304504_ENST00000472765_ARHGEF11_chr1_156931567_ENST00000368194_length(transcript)=5102nt_BP=393nt
GTCTGGTTCTCTCTCTCCAGAAGGTTCTGCCGGTTCCCCCAGCTCTGGGTACCCGGCTCTGCATCGCGTCGCCATGATGGGCCATCGTCC
AGTGCTCGTGCTCATTAGGTCTAGCTTTATATTCTTGGCCCATCCCTTAGTAGCGGTAATTTAAATGTTTCAATCTGTATTACGGAGTTA
ACAGTATTTCCTAGTAGAATTGTGAGAATTAAATGAGGCCAGAACACAAAGCGTGAATCCGGAAGAAAAGTTCAATCTGGAAACATCAAT
GCTGCCAAGACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTG
ATGACCAATGATGGCAATGCCATTCTTCGAGAGCTTTTTTACCTGTGTGCAGAAGTTTATCAGCAGGCAAGCCCCAAGGATTCCCGAAGC
TTGGGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCTGAGATGCTACAGGCTGAAATTGACTCG
CGCCTGCGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAGAGCAGATCCACGACTAC
AGAACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGATGGGGACCCTCTCCGAGAGCGCCAAGTG
GCTGAGAAGCAGCTGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATACCTAC
ATGAGCCATGCTGGGATCCGTCTTCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGTGGCTA
CCGTTCTTCCCTAAGACCAAGAAGAGCAGCAATTCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCAAATAC
ATTGGGAAGCCCAAAAGCTCTTCTCAAAGCACATTTCATATTCCCTTGTCCCCTGTGGAAGTCAAACCAGGCAATGTGAGGAACATCATT
CAGCACTTTGAGAACAACCAGCAGTATGATGCCCCAGAACCTGGGACACAACGACTCTCGACCGGAAGCTTTCCTGAGGACCTGCTGGAG
AGTGACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAAGCCTCAAGGGCCGGGAAGAGATGAAACGGTCTCGAAAGGCAGAGAAC
GTGCCCCGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACTCGCCTGCACCAGTCAGCCTCGTCCTCTACCTCCAGCCTC
TCCACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATTGAGTCCCCCAGTTTGGGGTTCTGCACA
GATACCCTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCCAAAATTGGCAGCATACA
GTGGGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAATGAGCTGTTTGTGACTGAAGCTTCCCAC
CTGCGCACACTCCGGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGCTCTTC
CCGAACCTGCCTGAACTCATAGAGATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAGAGATC
AGTGACCTCATGCTGGCCCGGTTTGATGGCCCTGCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAATAGCC
CTAGAGCTAATCAAGACCAAGCAACGCAAGGAGAGTCGATTCCAGCTCTTCATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGCGGCTG
CAGCTGAGAGACCTCATCATCTCTGAGATGCAGCGGCTCACCAAGTACCCGCTGCTGCTGGAGAGCATCATCAAGCACACAGAGGGTGGC
ACCTCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCCGGGAGATTCTCAAGTATGTGAATGAAGCGGTAAAACAAACAGAGAAC
CGCCACCGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAGAGGGCCAGCAACCCCCTGGCAGCAGAGTTCAAGAGCCTG
GATCTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAGACCTTGGACCTCCACGTGCTGCTGCTG
GAGGACCTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGGGCTCCTCAGACAGCAAG
CAGACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAACGGGCCTTCTTCATCATCTGCACCTCC
AAGCTGGGCCCACCCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCGTGCGG
AATGCCACCAGGCACCCCGGAGCTGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCACACCC
AGCAGGGTAGAACTGGATGACTCAGACGTGTTCCATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGAGGGTC
CAAGGGAAGCACCAGGTCCTGCTAGAGGACCCTGAGCAGGAGGGCAGTGCAGAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTTCCACA
TCCCTGGATGGAGAGAACAGGGGCATCAGGACAAGGAACCCCATCCACTTGGCCTTCCCAGGCCCTCTGTTCATGGAAGGGCTCGCTGAC
TCCGCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGTGGAGCCTGCTGCCAGGTCACACCATGGAAACTCAGGCTGCCCAGGAG
CCCGAGGACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCACCCCTGGGACCCAGGCTCCCCAGGGCAAGCACCCCCTGGG
GGTGAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATGGGTCTCTGTTCTCTGGAACACCTACCC
CCAAGGACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCACAGAGGCAGCAGGAGGT
TACAAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGTGGCCAGTCAGAGCCTGGGCCACCTGAA
GTGGAAGGCGGAACAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAGAGGCA
CCCATGAGCCCCCCTCAGCCTGACAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTGCAGGGAGGCAACGATGATCCAAGACGC
CCCAGCCGCTCTCCTCCAAGCCTGGCCCTCAGGGACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACAGGCTC
AAGGATATGGAGCTGGCCCACAGAGAGCTGCTCAAGTCCCTTGGGGGAGAGTCATCTGGTGGCACCACGCCTGTGGGCAGTTTCCACACA
GAAGCAGCTAGATGGACAGATGGCTCCCTCTCACCTCCCGCTAAGGAGCCCCTAGCTTCTGACTCCAGGAACAGCCATGAACTGGGGCCC
TGCCCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAGCAGACGCAGCCGCGTCACCAGGACCATAACCGTACAAACCACCAAAT
CCTCTGCGTCCCCACTCCTCCTTCAGGGACTGGCCTGAGACCGGGGCACAGGGTAGGGGGGATCCCAACACTCCTCCCTGTGGAGGAGGC
AGTTAGGGAAACTAGGATCCAGCCAAGGCCCGGGGGGAGACCCGCATGTTGCTTGGTCTGCTCAAGTCGGAGTCAGGTTTCAGTGTCTTT
TCCCTCCCTTAGCCCAACCCTCCAAGGCCTCATGTCTCCTAAGCATGCTGACTGCATCCGAAAGGCCCCCACTCACCATGGTCTGCCCTC
ACCCCACATATGTGTGTACACGCGCACGCCTGTATGTGCGCTGCCCTCAGACATGCAAGTGAAAGGAGGAGGCTTCTGTGTAAATGCACT
TTCTTCCTCCCCTCTTTCTCCATAAGACCCCAGGCAGAGGTGGGTGCCTCCCCTCCCCTCTTTGTCACTTTGGTTTCCTATAAATATGTA
TGTATCGTATGTGCATCTTTGCTATTGTAAATAACTTTGACCTTTTTTGTTCCTGTTCCTGAAGTGCTGGAGGCAGTTATGGAAGGAGCT
GCTTAGGGAAGAGGGGTTTCACTTGTATCTCCTTAGTTAACAACCCAGTTCCAGGATCGAGCCTAAAGCGGGAGCCAGGCCTGAGTGTTC
CTGTCCCTGTGAGTGGGAAGGTCTTCTGGCTCCCCATCCCACCTGGCTCCAGAGCCTGCCCTCCACAGCTTGCTGCCAAGCTACTCCCTC
CCTCCCTGGACTTCTCATCTTCACAAGATGGGGATCATGGGGGTTTCTTACCCCACCTATGTCCCCCTCTTCCCCACCCTGTCCCTGTAG
AAAACCAGTGAAGCAGGTACGGAGCTGAGGACTGGGCCCCAGGAGGTGGGGACAGGGGTCTGAATGCCGAGTCCCTGAATTCACCCAGGA
CCATCCAAGGGGCCACCGCAGCATTGGCCCCATCACCACGTCCTCACCCAACTCTCCCTGATGAATAGAATATACACACTGTGCTAGGTG
TATATATACATATATATATATATAAATATATATATAATATATAAAATATAGATATGGAAATGACTGTTCTGCTGTTAAGATAATGTATAC

>14293_14293_4_CCT3-ARHGEF11_CCT3_chr1_156304504_ENST00000472765_ARHGEF11_chr1_156931567_ENST00000368194_length(amino acids)=1211AA_BP=29
MGPKSMMKMLLDPMGGIVMTNDGNAILRELFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVL
CEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREAR
PSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAP
EPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPF
TPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFY
QRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKES
RFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLD
ATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAV
LIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFH
GEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHL
ILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESP
ELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPA
GQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CCT3-ARHGEF11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CCT3-ARHGEF11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CCT3-ARHGEF11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource