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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCT3-GON4L (FusionGDB2 ID:14297)

Fusion Gene Summary for CCT3-GON4L

check button Fusion gene summary
Fusion gene informationFusion gene name: CCT3-GON4L
Fusion gene ID: 14297
HgeneTgene
Gene symbol

CCT3

GON4L

Gene ID

7203

54856

Gene namechaperonin containing TCP1 subunit 3gon-4 like
SynonymsCCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5GON-4|GON4|YARP
Cytomap

1q22

1q22

Type of geneprotein-codingprotein-coding
DescriptionT-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5GON-4-like protein2610100B20RikYY1AP related proteinYY1AP-related protein1gon-4 homolog
Modification date2020032720200320
UniProtAcc

P49368

Q3T8J9

Ensembl transtripts involved in fusion geneENST00000295688, ENST00000368259, 
ENST00000368261, ENST00000472765, 
ENST00000368256, 		ENST00000271883, 
ENST00000361040, ENST00000368331, 
ENST00000437809, ENST00000471341, 
Fusion gene scores* DoF score24 X 18 X 12=518411 X 14 X 10=1540
# samples 2817
** MAII scorelog2(28/5184*10)=-4.21056698593966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1540*10)=-3.17932369944456
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCT3 [Title/Abstract] AND GON4L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCT3(156303338)-GON4L(155802741), # samples:2
GON4L(155726749)-CCT3(156279094), # samples:2
Anticipated loss of major functional domain due to fusion event.GON4L-CCT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GON4L-CCT3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GON4L-CCT3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CCT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GON4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-8262-01ACCT3chr1

156303338

-GON4Lchr1

155802741

-
ChimerDB4PRADTCGA-HC-8262CCT3chr1

156303338

-GON4Lchr1

155802741

-
ChimerDB4PRADTCGA-HC-8262CCT3chr1

156303338

-GON4Lchr1

155804195

-


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Fusion Gene ORF analysis for CCT3-GON4L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000295688ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000295688ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000295688ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000295688ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000295688ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000295688ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000295688ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000295688ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000295688ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000295688ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000368259ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368259ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000368259ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368259ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000368259ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368259ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000368259ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368259ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000368259ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368259ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000368261ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368261ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000368261ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368261ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000368261ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368261ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000368261ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368261ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000368261ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368261ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000472765ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000472765ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000472765ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000472765ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000472765ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000472765ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000472765ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000472765ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155804195

-
5CDS-intronENST00000472765ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000472765ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155804195

-
5UTR-intronENST00000368256ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155802741

-
5UTR-intronENST00000368256ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155804195

-
5UTR-intronENST00000368256ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155802741

-
5UTR-intronENST00000368256ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155804195

-
5UTR-intronENST00000368256ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155802741

-
5UTR-intronENST00000368256ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155804195

-
5UTR-intronENST00000368256ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155802741

-
5UTR-intronENST00000368256ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155804195

-
5UTR-intronENST00000368256ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155802741

-
5UTR-intronENST00000368256ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155804195

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CCT3-GON4L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCT3-GON4L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:156303338/:155802741)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCT3

P49368

GON4L

Q3T8J9

FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.FUNCTION: Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CCT3-GON4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CCT3-GON4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCT3-GON4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCT3-GON4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource