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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCT4-ACP1 (FusionGDB2 ID:14317)

Fusion Gene Summary for CCT4-ACP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCT4-ACP1
Fusion gene ID: 14317
HgeneTgene
Gene symbol

CCT4

ACP1

Gene ID

10575

4706

Gene namechaperonin containing TCP1 subunit 4NADH:ubiquinone oxidoreductase subunit AB1
SynonymsCCT-DELTA|Cctd|SRBACP|ACP1|FASN2A|SDAP
Cytomap

2p15

16p12.2

Type of geneprotein-codingprotein-coding
DescriptionT-complex protein 1 subunit deltaTCP-1-deltachaperonin containing TCP1, subunit 4 (delta)chaperonin containing t-complex polypeptide 1, delta subunitstimulator of TAR RNA-bindingacyl carrier protein, mitochondrialCI-SDAPNADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDaNADH-ubiquinone oxidoreductase 9.6 kDa subunitNADH:ubiquinone oxidoreductase SDAP subunitcomplex I SDAP subunitmitochondrial acyl carrier prot
Modification date2020031320200313
UniProtAcc

P50991

P24666

Ensembl transtripts involved in fusion geneENST00000394440, ENST00000538252, 
ENST00000544079, ENST00000544185, 
ENST00000461540, 		ENST00000484464, 
ENST00000272065, ENST00000272067, 
ENST00000405233, ENST00000407983, 
ENST00000439645, 
Fusion gene scores* DoF score10 X 12 X 4=4804 X 3 X 3=36
# samples 124
** MAII scorelog2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCT4 [Title/Abstract] AND ACP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCT4(62096574)-ACP1(271865), # samples:1
Anticipated loss of major functional domain due to fusion event.CCT4-ACP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CCT4-ACP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CCT4-ACP1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CCT4-ACP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CCT4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1403CCT4chr2

62096574

-ACP1chr2

271865

+


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Fusion Gene ORF analysis for CCT4-ACP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000394440ENST00000484464CCT4chr2

62096574

-ACP1chr2

271865

+
5CDS-3UTRENST00000538252ENST00000484464CCT4chr2

62096574

-ACP1chr2

271865

+
5CDS-3UTRENST00000544079ENST00000484464CCT4chr2

62096574

-ACP1chr2

271865

+
5CDS-3UTRENST00000544185ENST00000484464CCT4chr2

62096574

-ACP1chr2

271865

+
5UTR-3CDSENST00000461540ENST00000272065CCT4chr2

62096574

-ACP1chr2

271865

+
5UTR-3CDSENST00000461540ENST00000272067CCT4chr2

62096574

-ACP1chr2

271865

+
5UTR-3CDSENST00000461540ENST00000405233CCT4chr2

62096574

-ACP1chr2

271865

+
5UTR-3CDSENST00000461540ENST00000407983CCT4chr2

62096574

-ACP1chr2

271865

+
5UTR-3CDSENST00000461540ENST00000439645CCT4chr2

62096574

-ACP1chr2

271865

+
5UTR-3UTRENST00000461540ENST00000484464CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000394440ENST00000272065CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000394440ENST00000272067CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000394440ENST00000405233CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000394440ENST00000407983CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000394440ENST00000439645CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000544079ENST00000272065CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000544079ENST00000272067CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000544079ENST00000405233CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000544079ENST00000407983CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000544079ENST00000439645CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000544185ENST00000272065CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000544185ENST00000272067CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000544185ENST00000405233CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000544185ENST00000407983CCT4chr2

62096574

-ACP1chr2

271865

+
Frame-shiftENST00000544185ENST00000439645CCT4chr2

62096574

-ACP1chr2

271865

+
In-frameENST00000538252ENST00000272065CCT4chr2

62096574

-ACP1chr2

271865

+
In-frameENST00000538252ENST00000272067CCT4chr2

62096574

-ACP1chr2

271865

+
In-frameENST00000538252ENST00000405233CCT4chr2

62096574

-ACP1chr2

271865

+
In-frameENST00000538252ENST00000407983CCT4chr2

62096574

-ACP1chr2

271865

+
In-frameENST00000538252ENST00000439645CCT4chr2

62096574

-ACP1chr2

271865

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000538252CCT4chr262096574-ENST00000272067ACP1chr2271865+335819453551995546
ENST00000538252CCT4chr262096574-ENST00000272065ACP1chr2271865+335819453551995546
ENST00000538252CCT4chr262096574-ENST00000407983ACP1chr2271865+254019453551995546
ENST00000538252CCT4chr262096574-ENST00000439645ACP1chr2271865+245819453551995546
ENST00000538252CCT4chr262096574-ENST00000405233ACP1chr2271865+301219453551995546

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000538252ENST00000272067CCT4chr262096574-ACP1chr2271865+0.0008598640.99914014
ENST00000538252ENST00000272065CCT4chr262096574-ACP1chr2271865+0.0010537120.99894625
ENST00000538252ENST00000407983CCT4chr262096574-ACP1chr2271865+0.0012803790.9987197
ENST00000538252ENST00000439645CCT4chr262096574-ACP1chr2271865+0.0010830150.998917
ENST00000538252ENST00000405233CCT4chr262096574-ACP1chr2271865+0.0008132180.9991868

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Fusion Genomic Features for CCT4-ACP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CCT4chr262096574-ACP1chr2271865+0.0556198430.94438016
CCT4chr262096574-ACP1chr2271865+0.0556198430.94438016

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CCT4-ACP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:62096574/chr2:271865)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCT4

P50991

ACP1

P24666

FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.FUNCTION: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CCT4-ACP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14317_14317_1_CCT4-ACP1_CCT4_chr2_62096574_ENST00000538252_ACP1_chr2_271865_ENST00000272065_length(transcript)=3358nt_BP=1945nt
GAAGGTTCGTGAAGGCAGTGAGGGCTTACCGTTATTACACTGCGGCCGGCCAGAATCCGGGTCCATCCGTCCTTCCCGAGCCAACCCAGA
CACAGCGGAGTTTGCCATGCCCGAGAATGTGGCACCCCGGAGCGGGGCGACTGCCGGGGCTGCCGGCGGCCGCGGGAAAGGCGCCTATCA
GGACCGCGACAAGCCAGCCCAGATCCGCTTCAGCAACATTTCCGCCGCCAAAGAAGCAGCCCAGTGGAGGGATCCTTATTTCTGTTTTTC
TGCCGATGATCGCCAACCCGGAGTATGGAGGCCTTTGGACTTGCCCCATTTTGCATCTTAATCTCCCTTAGTTTTTCATCCTGCACTGTG
CATCATTCATATTGGAGCCGAAAGCAGTTCAAAATGCCGAGGATTGCATGCAGTCTTCACTAGGGATCTGACGCTTGAGGGCTGTCGCTT
ATTGCTTATTGGAACTGCGGTTGCTGATGCTATTAGAACAAGCCTTGGACCAAAAGGAATGGATAAAATGATTCAAGATGGAAAAGGTGA
TGTAACCATTACAAATGATGGTGCTACCATTCTGAAACAAATGCAAGTATTACATCCAGCAGCCAGAATGCTGGTGGAGCTGTCTAAGGC
TCAAGATATAGAAGCAGGAGATGGCACCACATCAGTAGTCATCATTGCTGGCTCCCTCTTAGATTCTTGTACCAAGCTTCTTCAGAAAGG
GATTCATCCAACCATCATTTCTGAGTCATTCCAGAAGGCCCTGGAAAAGGGCATTGAAATCTTGACTGACATGTCTCGACCTGTGGAACT
GAGTGACAGAGAAACTTTGTTAAATAGTGCAACCACTTCACTGAACTCAAAGGTGGTTTCTCAGTATTCAAGTCTGCTTTCTCCAATGAG
TGTAAATGCAGTGATGAAAGTGATTGACCCAGCCACAGCCACCAGTGTAGATCTTAGAGATATTAAAATAGTTAAGAAGCTTGGTGGGAC
AATTGATGACTGTGAGTTGGTGGAAGGGCTGGTTCTCACCCAAAAAGTGTCAAATTCTGGCATAACCAGAGTTGAAAAGGCCAAGATTGG
GCTTATTCAGTTTTGCTTATCTGCTCCCAAAACAGACATGGATAATCAAATAGTGGTTTCTGACTATGCCCAGATGGACCGAGTGCTGCG
AGAAGAGAGAGCCTATATTTTAAATTTAGTGAAGCAAATTAAAAAAACAGGATGTAATGTCCTTCTCATACAGAAATCTATTCTAAGAGA
TGCTCTTAGTGATCTTGCATTACACTTTCTGAATAAAATGAAGATCATGGTGATTAAGGATATTGAAAGAGAAGACATTGAATTCATTTG
TAAGACAATTGGAACCAAGCCAGTTGCTCATATTGACCAATTTACTGCTGACATGCTGGGTTCTGCTGAGTTAGCTGAGGAGGTCAATTT
AAATGGTTCTGGCAAACTGCTCAAGATTACAGGCTGTGCCAGCCCTGGAAAAACAGTTACAATTGTTGTTCGTGGTTCTAACAAACTGGT
GATTGAAGAAGCTGAGCGCTCCATTCATGATGCCCTATGTGTTATTCGTTGTTTAGTGAAGAAGAGGGCTCTTATTGCAGGAGGTGGTGC
TCCAGAAATAGAGTTGGCCCTACGATTAACTGAATATTCACGAACACTGAGTGGTATGGAATCCTACTGCGTTCGTGCTTTTGCAGATGC
TATGGAGGTCATTCCATCTACACTAGCTGAAAATGCCGGCCTGAATCCCATTTCTACAGTAACAGAACTAAGAAACCGGCATGCCCAGGG
AGAAAAAACTGCAGGCATTAATGTCCGAAAGGGTGGTATTTCCAACATTTTGGAGGAACTGGTTGTCCAGCCTCTGTTGGTATCAGTCAG
TGCTCTGACTCTTGCAACTGAAACTGTTCGGAGCATTCTGAAAATAGATGATGTGGTAACATTTGTCGATCACCCATTGCAGAAGCAGTT
TTCAGGAAACTTGTAACCGATCAAAACATCTCAGAGAATTGGAGGGTAGACAGCGCGGCAACTTCCGGGTATGAGATAGGGAACCCCCCT
GACTACCGAGGGCAGAGCTGCATGAAGAGGCACGGCATTCCCATGAGCCACGTTGCCCGGCAGATTACCAAAGAAGATTTTGCCACATTT
GATTATATACTATGTATGGATGAAAGCAATCTGAGAGATTTGAATAGAAAAAGTAATCAAGTTAAAACCTGCAAAGCTAAAATTGAACTA
CTTGGGAGCTATGATCCACAAAAACAACTTATTATTGAAGATCCCTATTATGGGAATGACTCTGACTTTGAGACGGTGTACCAGCAGTGT
GTCAGGTGCTGCAGAGCGTTCTTGGAGAAGGCCCACTGAGGCAGGTTCGTGCCCTGCTGCGGCCAGCCTGACTAGACCCCACCCTGAGGT
CCTGCATTTCTCAGTCGGTGTGTAATCACGTTCCAGGGCCCAAAGCCCAGCTCTTTGTTCAGTTGACTTACTGTTTCTTACCTTAAAAAG
TAATTGTAGATGGAAATCAGTTGTGTTTGGCAGGAGAATCAATAAAAATCTTTGATTCAGACAGCTTATGGGGTATTTTAAGCATTCTTA
GACTAGTTGAACATCTCACTTTGCCCCAGTTACAAAAATAGTAGAACAAGCAACATAAAACAATGAAGGAAAACCTCACTTGAAGGCCCA
GGTCAACATCTAAGCCTGTTGAGACTTAGATAATCGAGTCTACCTCTTCAGTAGGTTTGTGTGGATGGCCTGGAGGGCAGGTGCCCTCTG
CTCCCCAGTGCTACCTCTCTCTTCCCTAGGGCCTTTTGTGGATTGACAGTAGTCCCCTCCGTAGGAGCTCACAGTCTAGATTAGAAGTGT
TTTAATTTCTACACACCCATAGTGCACACTTGTATATTGAAAAGATAGGGAAGAGAGAAACATTTATGGAATCAGTCGTTGGCACCTTCA
ATACTTCATGATTTTTGTCGAGTTTACTTCATGAGGAGGTCAGCCCATTGGCTCCCATCTGAACCACTTTGCCTCTGAAACTTAATTACA
TCCAGAAAGAAGGACACTTGTATGCTAGTCTATGGTCAGTTGAGGAATATGACTGTTTTTATATGCACATGTAACCCAAATGTCCAATAT
AAATTGGCTTATTTTTTAAAATAATTTTAAAAGTTGGGAAAAGTGTTATTATTTGGCATGCTTAAATATTGAATAAGTATTCTTCATCAG
CATTTAATAAATGTATAGGCAGATGTAAGGTAATTTCTGTGTATTTTGAGATAATGTCAAAATCATGAATATTTCAAAATAAACTGGGGA

>14317_14317_1_CCT4-ACP1_CCT4_chr2_62096574_ENST00000538252_ACP1_chr2_271865_ENST00000272065_length(amino acids)=546AA_BP=530
MCIIHIGAESSSKCRGLHAVFTRDLTLEGCRLLLIGTAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELS
KAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELSDRETLLNSATTSLNSKVVSQYSSLLSP
MSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRV
LREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEV
NLNGSGKLLKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFA
DAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVTFVDHPLQK

--------------------------------------------------------------
>14317_14317_2_CCT4-ACP1_CCT4_chr2_62096574_ENST00000538252_ACP1_chr2_271865_ENST00000272067_length(transcript)=3358nt_BP=1945nt
GAAGGTTCGTGAAGGCAGTGAGGGCTTACCGTTATTACACTGCGGCCGGCCAGAATCCGGGTCCATCCGTCCTTCCCGAGCCAACCCAGA
CACAGCGGAGTTTGCCATGCCCGAGAATGTGGCACCCCGGAGCGGGGCGACTGCCGGGGCTGCCGGCGGCCGCGGGAAAGGCGCCTATCA
GGACCGCGACAAGCCAGCCCAGATCCGCTTCAGCAACATTTCCGCCGCCAAAGAAGCAGCCCAGTGGAGGGATCCTTATTTCTGTTTTTC
TGCCGATGATCGCCAACCCGGAGTATGGAGGCCTTTGGACTTGCCCCATTTTGCATCTTAATCTCCCTTAGTTTTTCATCCTGCACTGTG
CATCATTCATATTGGAGCCGAAAGCAGTTCAAAATGCCGAGGATTGCATGCAGTCTTCACTAGGGATCTGACGCTTGAGGGCTGTCGCTT
ATTGCTTATTGGAACTGCGGTTGCTGATGCTATTAGAACAAGCCTTGGACCAAAAGGAATGGATAAAATGATTCAAGATGGAAAAGGTGA
TGTAACCATTACAAATGATGGTGCTACCATTCTGAAACAAATGCAAGTATTACATCCAGCAGCCAGAATGCTGGTGGAGCTGTCTAAGGC
TCAAGATATAGAAGCAGGAGATGGCACCACATCAGTAGTCATCATTGCTGGCTCCCTCTTAGATTCTTGTACCAAGCTTCTTCAGAAAGG
GATTCATCCAACCATCATTTCTGAGTCATTCCAGAAGGCCCTGGAAAAGGGCATTGAAATCTTGACTGACATGTCTCGACCTGTGGAACT
GAGTGACAGAGAAACTTTGTTAAATAGTGCAACCACTTCACTGAACTCAAAGGTGGTTTCTCAGTATTCAAGTCTGCTTTCTCCAATGAG
TGTAAATGCAGTGATGAAAGTGATTGACCCAGCCACAGCCACCAGTGTAGATCTTAGAGATATTAAAATAGTTAAGAAGCTTGGTGGGAC
AATTGATGACTGTGAGTTGGTGGAAGGGCTGGTTCTCACCCAAAAAGTGTCAAATTCTGGCATAACCAGAGTTGAAAAGGCCAAGATTGG
GCTTATTCAGTTTTGCTTATCTGCTCCCAAAACAGACATGGATAATCAAATAGTGGTTTCTGACTATGCCCAGATGGACCGAGTGCTGCG
AGAAGAGAGAGCCTATATTTTAAATTTAGTGAAGCAAATTAAAAAAACAGGATGTAATGTCCTTCTCATACAGAAATCTATTCTAAGAGA
TGCTCTTAGTGATCTTGCATTACACTTTCTGAATAAAATGAAGATCATGGTGATTAAGGATATTGAAAGAGAAGACATTGAATTCATTTG
TAAGACAATTGGAACCAAGCCAGTTGCTCATATTGACCAATTTACTGCTGACATGCTGGGTTCTGCTGAGTTAGCTGAGGAGGTCAATTT
AAATGGTTCTGGCAAACTGCTCAAGATTACAGGCTGTGCCAGCCCTGGAAAAACAGTTACAATTGTTGTTCGTGGTTCTAACAAACTGGT
GATTGAAGAAGCTGAGCGCTCCATTCATGATGCCCTATGTGTTATTCGTTGTTTAGTGAAGAAGAGGGCTCTTATTGCAGGAGGTGGTGC
TCCAGAAATAGAGTTGGCCCTACGATTAACTGAATATTCACGAACACTGAGTGGTATGGAATCCTACTGCGTTCGTGCTTTTGCAGATGC
TATGGAGGTCATTCCATCTACACTAGCTGAAAATGCCGGCCTGAATCCCATTTCTACAGTAACAGAACTAAGAAACCGGCATGCCCAGGG
AGAAAAAACTGCAGGCATTAATGTCCGAAAGGGTGGTATTTCCAACATTTTGGAGGAACTGGTTGTCCAGCCTCTGTTGGTATCAGTCAG
TGCTCTGACTCTTGCAACTGAAACTGTTCGGAGCATTCTGAAAATAGATGATGTGGTAACATTTGTCGATCACCCATTGCAGAAGCAGTT
TTCAGGAAACTTGTAACCGATCAAAACATCTCAGAGAATTGGGTCATTGACAGCGGTGCTGTTTCTGACTGGAACGTGGGCCGGTCCCCA
GACCCAAGAGCTGTGAGCTGCCTAAGAAATCATGGCATTCACACAGCCCATAAAGCAAGACAGATTACCAAAGAAGATTTTGCCACATTT
GATTATATACTATGTATGGATGAAAGCAATCTGAGAGATTTGAATAGAAAAAGTAATCAAGTTAAAACCTGCAAAGCTAAAATTGAACTA
CTTGGGAGCTATGATCCACAAAAACAACTTATTATTGAAGATCCCTATTATGGGAATGACTCTGACTTTGAGACGGTGTACCAGCAGTGT
GTCAGGTGCTGCAGAGCGTTCTTGGAGAAGGCCCACTGAGGCAGGTTCGTGCCCTGCTGCGGCCAGCCTGACTAGACCCCACCCTGAGGT
CCTGCATTTCTCAGTCGGTGTGTAATCACGTTCCAGGGCCCAAAGCCCAGCTCTTTGTTCAGTTGACTTACTGTTTCTTACCTTAAAAAG
TAATTGTAGATGGAAATCAGTTGTGTTTGGCAGGAGAATCAATAAAAATCTTTGATTCAGACAGCTTATGGGGTATTTTAAGCATTCTTA
GACTAGTTGAACATCTCACTTTGCCCCAGTTACAAAAATAGTAGAACAAGCAACATAAAACAATGAAGGAAAACCTCACTTGAAGGCCCA
GGTCAACATCTAAGCCTGTTGAGACTTAGATAATCGAGTCTACCTCTTCAGTAGGTTTGTGTGGATGGCCTGGAGGGCAGGTGCCCTCTG
CTCCCCAGTGCTACCTCTCTCTTCCCTAGGGCCTTTTGTGGATTGACAGTAGTCCCCTCCGTAGGAGCTCACAGTCTAGATTAGAAGTGT
TTTAATTTCTACACACCCATAGTGCACACTTGTATATTGAAAAGATAGGGAAGAGAGAAACATTTATGGAATCAGTCGTTGGCACCTTCA
ATACTTCATGATTTTTGTCGAGTTTACTTCATGAGGAGGTCAGCCCATTGGCTCCCATCTGAACCACTTTGCCTCTGAAACTTAATTACA
TCCAGAAAGAAGGACACTTGTATGCTAGTCTATGGTCAGTTGAGGAATATGACTGTTTTTATATGCACATGTAACCCAAATGTCCAATAT
AAATTGGCTTATTTTTTAAAATAATTTTAAAAGTTGGGAAAAGTGTTATTATTTGGCATGCTTAAATATTGAATAAGTATTCTTCATCAG
CATTTAATAAATGTATAGGCAGATGTAAGGTAATTTCTGTGTATTTTGAGATAATGTCAAAATCATGAATATTTCAAAATAAACTGGGGA

>14317_14317_2_CCT4-ACP1_CCT4_chr2_62096574_ENST00000538252_ACP1_chr2_271865_ENST00000272067_length(amino acids)=546AA_BP=530
MCIIHIGAESSSKCRGLHAVFTRDLTLEGCRLLLIGTAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELS
KAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELSDRETLLNSATTSLNSKVVSQYSSLLSP
MSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRV
LREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEV
NLNGSGKLLKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFA
DAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVTFVDHPLQK

--------------------------------------------------------------
>14317_14317_3_CCT4-ACP1_CCT4_chr2_62096574_ENST00000538252_ACP1_chr2_271865_ENST00000405233_length(transcript)=3012nt_BP=1945nt
GAAGGTTCGTGAAGGCAGTGAGGGCTTACCGTTATTACACTGCGGCCGGCCAGAATCCGGGTCCATCCGTCCTTCCCGAGCCAACCCAGA
CACAGCGGAGTTTGCCATGCCCGAGAATGTGGCACCCCGGAGCGGGGCGACTGCCGGGGCTGCCGGCGGCCGCGGGAAAGGCGCCTATCA
GGACCGCGACAAGCCAGCCCAGATCCGCTTCAGCAACATTTCCGCCGCCAAAGAAGCAGCCCAGTGGAGGGATCCTTATTTCTGTTTTTC
TGCCGATGATCGCCAACCCGGAGTATGGAGGCCTTTGGACTTGCCCCATTTTGCATCTTAATCTCCCTTAGTTTTTCATCCTGCACTGTG
CATCATTCATATTGGAGCCGAAAGCAGTTCAAAATGCCGAGGATTGCATGCAGTCTTCACTAGGGATCTGACGCTTGAGGGCTGTCGCTT
ATTGCTTATTGGAACTGCGGTTGCTGATGCTATTAGAACAAGCCTTGGACCAAAAGGAATGGATAAAATGATTCAAGATGGAAAAGGTGA
TGTAACCATTACAAATGATGGTGCTACCATTCTGAAACAAATGCAAGTATTACATCCAGCAGCCAGAATGCTGGTGGAGCTGTCTAAGGC
TCAAGATATAGAAGCAGGAGATGGCACCACATCAGTAGTCATCATTGCTGGCTCCCTCTTAGATTCTTGTACCAAGCTTCTTCAGAAAGG
GATTCATCCAACCATCATTTCTGAGTCATTCCAGAAGGCCCTGGAAAAGGGCATTGAAATCTTGACTGACATGTCTCGACCTGTGGAACT
GAGTGACAGAGAAACTTTGTTAAATAGTGCAACCACTTCACTGAACTCAAAGGTGGTTTCTCAGTATTCAAGTCTGCTTTCTCCAATGAG
TGTAAATGCAGTGATGAAAGTGATTGACCCAGCCACAGCCACCAGTGTAGATCTTAGAGATATTAAAATAGTTAAGAAGCTTGGTGGGAC
AATTGATGACTGTGAGTTGGTGGAAGGGCTGGTTCTCACCCAAAAAGTGTCAAATTCTGGCATAACCAGAGTTGAAAAGGCCAAGATTGG
GCTTATTCAGTTTTGCTTATCTGCTCCCAAAACAGACATGGATAATCAAATAGTGGTTTCTGACTATGCCCAGATGGACCGAGTGCTGCG
AGAAGAGAGAGCCTATATTTTAAATTTAGTGAAGCAAATTAAAAAAACAGGATGTAATGTCCTTCTCATACAGAAATCTATTCTAAGAGA
TGCTCTTAGTGATCTTGCATTACACTTTCTGAATAAAATGAAGATCATGGTGATTAAGGATATTGAAAGAGAAGACATTGAATTCATTTG
TAAGACAATTGGAACCAAGCCAGTTGCTCATATTGACCAATTTACTGCTGACATGCTGGGTTCTGCTGAGTTAGCTGAGGAGGTCAATTT
AAATGGTTCTGGCAAACTGCTCAAGATTACAGGCTGTGCCAGCCCTGGAAAAACAGTTACAATTGTTGTTCGTGGTTCTAACAAACTGGT
GATTGAAGAAGCTGAGCGCTCCATTCATGATGCCCTATGTGTTATTCGTTGTTTAGTGAAGAAGAGGGCTCTTATTGCAGGAGGTGGTGC
TCCAGAAATAGAGTTGGCCCTACGATTAACTGAATATTCACGAACACTGAGTGGTATGGAATCCTACTGCGTTCGTGCTTTTGCAGATGC
TATGGAGGTCATTCCATCTACACTAGCTGAAAATGCCGGCCTGAATCCCATTTCTACAGTAACAGAACTAAGAAACCGGCATGCCCAGGG
AGAAAAAACTGCAGGCATTAATGTCCGAAAGGGTGGTATTTCCAACATTTTGGAGGAACTGGTTGTCCAGCCTCTGTTGGTATCAGTCAG
TGCTCTGACTCTTGCAACTGAAACTGTTCGGAGCATTCTGAAAATAGATGATGTGGTAACATTTGTCGATCACCCATTGCAGAAGCAGTT
TTCAGGAAACTTGTAACCGATCAAAACATCTCAGAGAATTGGAGGGTAGACAGCGCGGCAACTTCCGGTGGGTCATTGACAGCGGTGCTG
TTTCTGACTGGAACGTGGGCCGGTCCCCAGACCCAAGAGCTGTGAGCTGCCTAAGAAATCATGGCATTCACACAGCCCATAAAGCAAGAC
AGGTAGACAAGCTCTTGTTCAATTTCTAATATATAGAGTCCAGTAACTTGAGAAGTAGCGAAAGGATTAACCAGACTTGTATATTAATGA
ATGTGTTTATTTAGGGTGAGCTTAACCAGCTATGGTGTGTCCATTTTGTTTCACTTCTGGTTGCACGGTGTTGAAAGACTTGCCTGACTT
TGGAATTTACTTATTAAAATGCACATAAAAGCTAGGTAATTTATAATGAGAGAGCCTGACTGTGAGCTGGGGCTGAGCGGTGCTCTGTCT
TCTGTTCCTTCCTGCATAATTTTTATTAAACATTTAGGCCATAGTAATCATCCTGCTGATATTGCAAGTTTGTTGCTAGAATGAGGTTAT
ATAATATATACAAAAACATTTTTTCAACTGTAAAGTGCCTTAGTAATATAGGGTAATACCAGCAACATTATGGATATATAATTATAGTCT
ATTGGGCCACACTTAAGTTTGGAGTCTAATAAAGTCACAATCAAATTCTGCAATTTCAATTGAAGATAACCTTGTCTTTATATTATGAAT
TAGAAGCTAAAGTTGATTTTTCTAAGAGTTCTTTATTTAAATGAAGTACTCTGGGACTGACCTTTTCGGAAATGGAATCTTCATTGGTCA
GGTGATTCAACATTTTTATACAATTTATCCATCCTCATCTCTTCAGGATTTGCATACCTTGCCAGTTTCTACTGGCCATTGTTGAAAATA
CATTTATTTGGAGAAGTCCAAAGCCAAGGGGCTCATGGGGCTGTGAAGTCCTTCTTGCTGCATCGTCCTGTGGTAGAAGGTGGAGGAGTC

>14317_14317_3_CCT4-ACP1_CCT4_chr2_62096574_ENST00000538252_ACP1_chr2_271865_ENST00000405233_length(amino acids)=546AA_BP=530
MCIIHIGAESSSKCRGLHAVFTRDLTLEGCRLLLIGTAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELS
KAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELSDRETLLNSATTSLNSKVVSQYSSLLSP
MSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRV
LREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEV
NLNGSGKLLKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFA
DAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVTFVDHPLQK

--------------------------------------------------------------
>14317_14317_4_CCT4-ACP1_CCT4_chr2_62096574_ENST00000538252_ACP1_chr2_271865_ENST00000407983_length(transcript)=2540nt_BP=1945nt
GAAGGTTCGTGAAGGCAGTGAGGGCTTACCGTTATTACACTGCGGCCGGCCAGAATCCGGGTCCATCCGTCCTTCCCGAGCCAACCCAGA
CACAGCGGAGTTTGCCATGCCCGAGAATGTGGCACCCCGGAGCGGGGCGACTGCCGGGGCTGCCGGCGGCCGCGGGAAAGGCGCCTATCA
GGACCGCGACAAGCCAGCCCAGATCCGCTTCAGCAACATTTCCGCCGCCAAAGAAGCAGCCCAGTGGAGGGATCCTTATTTCTGTTTTTC
TGCCGATGATCGCCAACCCGGAGTATGGAGGCCTTTGGACTTGCCCCATTTTGCATCTTAATCTCCCTTAGTTTTTCATCCTGCACTGTG
CATCATTCATATTGGAGCCGAAAGCAGTTCAAAATGCCGAGGATTGCATGCAGTCTTCACTAGGGATCTGACGCTTGAGGGCTGTCGCTT
ATTGCTTATTGGAACTGCGGTTGCTGATGCTATTAGAACAAGCCTTGGACCAAAAGGAATGGATAAAATGATTCAAGATGGAAAAGGTGA
TGTAACCATTACAAATGATGGTGCTACCATTCTGAAACAAATGCAAGTATTACATCCAGCAGCCAGAATGCTGGTGGAGCTGTCTAAGGC
TCAAGATATAGAAGCAGGAGATGGCACCACATCAGTAGTCATCATTGCTGGCTCCCTCTTAGATTCTTGTACCAAGCTTCTTCAGAAAGG
GATTCATCCAACCATCATTTCTGAGTCATTCCAGAAGGCCCTGGAAAAGGGCATTGAAATCTTGACTGACATGTCTCGACCTGTGGAACT
GAGTGACAGAGAAACTTTGTTAAATAGTGCAACCACTTCACTGAACTCAAAGGTGGTTTCTCAGTATTCAAGTCTGCTTTCTCCAATGAG
TGTAAATGCAGTGATGAAAGTGATTGACCCAGCCACAGCCACCAGTGTAGATCTTAGAGATATTAAAATAGTTAAGAAGCTTGGTGGGAC
AATTGATGACTGTGAGTTGGTGGAAGGGCTGGTTCTCACCCAAAAAGTGTCAAATTCTGGCATAACCAGAGTTGAAAAGGCCAAGATTGG
GCTTATTCAGTTTTGCTTATCTGCTCCCAAAACAGACATGGATAATCAAATAGTGGTTTCTGACTATGCCCAGATGGACCGAGTGCTGCG
AGAAGAGAGAGCCTATATTTTAAATTTAGTGAAGCAAATTAAAAAAACAGGATGTAATGTCCTTCTCATACAGAAATCTATTCTAAGAGA
TGCTCTTAGTGATCTTGCATTACACTTTCTGAATAAAATGAAGATCATGGTGATTAAGGATATTGAAAGAGAAGACATTGAATTCATTTG
TAAGACAATTGGAACCAAGCCAGTTGCTCATATTGACCAATTTACTGCTGACATGCTGGGTTCTGCTGAGTTAGCTGAGGAGGTCAATTT
AAATGGTTCTGGCAAACTGCTCAAGATTACAGGCTGTGCCAGCCCTGGAAAAACAGTTACAATTGTTGTTCGTGGTTCTAACAAACTGGT
GATTGAAGAAGCTGAGCGCTCCATTCATGATGCCCTATGTGTTATTCGTTGTTTAGTGAAGAAGAGGGCTCTTATTGCAGGAGGTGGTGC
TCCAGAAATAGAGTTGGCCCTACGATTAACTGAATATTCACGAACACTGAGTGGTATGGAATCCTACTGCGTTCGTGCTTTTGCAGATGC
TATGGAGGTCATTCCATCTACACTAGCTGAAAATGCCGGCCTGAATCCCATTTCTACAGTAACAGAACTAAGAAACCGGCATGCCCAGGG
AGAAAAAACTGCAGGCATTAATGTCCGAAAGGGTGGTATTTCCAACATTTTGGAGGAACTGGTTGTCCAGCCTCTGTTGGTATCAGTCAG
TGCTCTGACTCTTGCAACTGAAACTGTTCGGAGCATTCTGAAAATAGATGATGTGGTAACATTTGTCGATCACCCATTGCAGAAGCAGTT
TTCAGGAAACTTGTAACCGATCAAAACATCTCAGAGAATTGGAGGGTAGACAGCGCGGCAACTTCCGGGTATGAGATAGGGAACCCCCCT
GACTACCGAGGGCAGAGCTGCATGAAGAGGCACGGCATTCCCATGAGCCACGTTGCCCGGCAGGTACCGTCCTTGGACTTGAAGTTGTGT
GTTTTGTGTTTCAGTGGGTCATTGACAGCGGTGCTGTTTCTGACTGGAACGTGGGCCGGTCCCCAGACCCAAGAGCTGTGAGCTGCCTAA
GAAATCATGGCATTCACACAGCCCATAAAGCAAGACAGGTAGACAAGCTCTTGTTCAATTTCTAATATATAGAGTCCAGTAACTTGAGAA
GTAGCGAAAGGATTAACCAGACTTGTATATTAATGAATGTGTTTATTTAGGGTGAGCTTAACCAGCTATGGTGTGTCCATTTTGTTTCAC
TTCTGGTTGCACGGTGTTGAAAGACTTGCCTGACTTTGGAATTTACTTATTAAAATGCACATAAAAGCTAGGTAATTTATAATGAGAGAG

>14317_14317_4_CCT4-ACP1_CCT4_chr2_62096574_ENST00000538252_ACP1_chr2_271865_ENST00000407983_length(amino acids)=546AA_BP=530
MCIIHIGAESSSKCRGLHAVFTRDLTLEGCRLLLIGTAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELS
KAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELSDRETLLNSATTSLNSKVVSQYSSLLSP
MSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRV
LREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEV
NLNGSGKLLKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFA
DAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVTFVDHPLQK

--------------------------------------------------------------
>14317_14317_5_CCT4-ACP1_CCT4_chr2_62096574_ENST00000538252_ACP1_chr2_271865_ENST00000439645_length(transcript)=2458nt_BP=1945nt
GAAGGTTCGTGAAGGCAGTGAGGGCTTACCGTTATTACACTGCGGCCGGCCAGAATCCGGGTCCATCCGTCCTTCCCGAGCCAACCCAGA
CACAGCGGAGTTTGCCATGCCCGAGAATGTGGCACCCCGGAGCGGGGCGACTGCCGGGGCTGCCGGCGGCCGCGGGAAAGGCGCCTATCA
GGACCGCGACAAGCCAGCCCAGATCCGCTTCAGCAACATTTCCGCCGCCAAAGAAGCAGCCCAGTGGAGGGATCCTTATTTCTGTTTTTC
TGCCGATGATCGCCAACCCGGAGTATGGAGGCCTTTGGACTTGCCCCATTTTGCATCTTAATCTCCCTTAGTTTTTCATCCTGCACTGTG
CATCATTCATATTGGAGCCGAAAGCAGTTCAAAATGCCGAGGATTGCATGCAGTCTTCACTAGGGATCTGACGCTTGAGGGCTGTCGCTT
ATTGCTTATTGGAACTGCGGTTGCTGATGCTATTAGAACAAGCCTTGGACCAAAAGGAATGGATAAAATGATTCAAGATGGAAAAGGTGA
TGTAACCATTACAAATGATGGTGCTACCATTCTGAAACAAATGCAAGTATTACATCCAGCAGCCAGAATGCTGGTGGAGCTGTCTAAGGC
TCAAGATATAGAAGCAGGAGATGGCACCACATCAGTAGTCATCATTGCTGGCTCCCTCTTAGATTCTTGTACCAAGCTTCTTCAGAAAGG
GATTCATCCAACCATCATTTCTGAGTCATTCCAGAAGGCCCTGGAAAAGGGCATTGAAATCTTGACTGACATGTCTCGACCTGTGGAACT
GAGTGACAGAGAAACTTTGTTAAATAGTGCAACCACTTCACTGAACTCAAAGGTGGTTTCTCAGTATTCAAGTCTGCTTTCTCCAATGAG
TGTAAATGCAGTGATGAAAGTGATTGACCCAGCCACAGCCACCAGTGTAGATCTTAGAGATATTAAAATAGTTAAGAAGCTTGGTGGGAC
AATTGATGACTGTGAGTTGGTGGAAGGGCTGGTTCTCACCCAAAAAGTGTCAAATTCTGGCATAACCAGAGTTGAAAAGGCCAAGATTGG
GCTTATTCAGTTTTGCTTATCTGCTCCCAAAACAGACATGGATAATCAAATAGTGGTTTCTGACTATGCCCAGATGGACCGAGTGCTGCG
AGAAGAGAGAGCCTATATTTTAAATTTAGTGAAGCAAATTAAAAAAACAGGATGTAATGTCCTTCTCATACAGAAATCTATTCTAAGAGA
TGCTCTTAGTGATCTTGCATTACACTTTCTGAATAAAATGAAGATCATGGTGATTAAGGATATTGAAAGAGAAGACATTGAATTCATTTG
TAAGACAATTGGAACCAAGCCAGTTGCTCATATTGACCAATTTACTGCTGACATGCTGGGTTCTGCTGAGTTAGCTGAGGAGGTCAATTT
AAATGGTTCTGGCAAACTGCTCAAGATTACAGGCTGTGCCAGCCCTGGAAAAACAGTTACAATTGTTGTTCGTGGTTCTAACAAACTGGT
GATTGAAGAAGCTGAGCGCTCCATTCATGATGCCCTATGTGTTATTCGTTGTTTAGTGAAGAAGAGGGCTCTTATTGCAGGAGGTGGTGC
TCCAGAAATAGAGTTGGCCCTACGATTAACTGAATATTCACGAACACTGAGTGGTATGGAATCCTACTGCGTTCGTGCTTTTGCAGATGC
TATGGAGGTCATTCCATCTACACTAGCTGAAAATGCCGGCCTGAATCCCATTTCTACAGTAACAGAACTAAGAAACCGGCATGCCCAGGG
AGAAAAAACTGCAGGCATTAATGTCCGAAAGGGTGGTATTTCCAACATTTTGGAGGAACTGGTTGTCCAGCCTCTGTTGGTATCAGTCAG
TGCTCTGACTCTTGCAACTGAAACTGTTCGGAGCATTCTGAAAATAGATGATGTGGTAACATTTGTCGATCACCCATTGCAGAAGCAGTT
TTCAGGAAACTTGTAACCGATCAAAACATCTCAGAGAATTGGGTCATTGACAGCGGTGCTGTTTCTGACTGGAACGTGGGCCGGTCCCCA
GACCCAAGAGCTGTGAGCTGCCTAAGAAATCATGGCATTCACACAGCCCATAAAGCAAGACAGGTAGACAAGCTCTTGTTCAATTTCTAA
TATATAGAGTCCAGTAACTTGAGAAGTAGCGAAAGGATTAACCAGACTTGTATATTAATGAATGTGTTTATTTAGGGTGAGCTTAACCAG
CTATGGTGTGTCCATTTTGTTTCACTTCTGGTTGCACGGTGTTGAAAGACTTGCCTGACTTTGGAATTTACTTATTAAAATGCACATAAA
AGCTAGGTAATTTATAATGAGAGAGCCTGACTGTGAGCTGGGGCTGAGCGGTGCTCTGTCTTCTGTTCCTTCCTGCATAATTTTTATTAA

>14317_14317_5_CCT4-ACP1_CCT4_chr2_62096574_ENST00000538252_ACP1_chr2_271865_ENST00000439645_length(amino acids)=546AA_BP=530
MCIIHIGAESSSKCRGLHAVFTRDLTLEGCRLLLIGTAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELS
KAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELSDRETLLNSATTSLNSKVVSQYSSLLSP
MSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRV
LREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEV
NLNGSGKLLKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFA
DAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVTFVDHPLQK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCT4-ACP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCT4-ACP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCT4-ACP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource