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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCT5-CDIPT (FusionGDB2 ID:14328)

Fusion Gene Summary for CCT5-CDIPT

check button Fusion gene summary
Fusion gene informationFusion gene name: CCT5-CDIPT
Fusion gene ID: 14328
HgeneTgene
Gene symbol

CCT5

CDIPT

Gene ID

22948

10423

Gene namechaperonin containing TCP1 subunit 5CDP-diacylglycerol--inositol 3-phosphatidyltransferase
SynonymsCCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilonPIS|PIS1
Cytomap

5p15.2

16p11.2

Type of geneprotein-codingprotein-coding
DescriptionT-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69CDP-diacylglycerol--inositol 3-phosphatidyltransferasePI synthasePtdIns synthasephosphatidylinositol synthase
Modification date2020031320200313
UniProtAcc

P48643

O14735

Ensembl transtripts involved in fusion geneENST00000280326, ENST00000503026, 
ENST00000506600, ENST00000515390, 
ENST00000515676, 		ENST00000563415, 
ENST00000561555, ENST00000566113, 
ENST00000567459, ENST00000569956, 
ENST00000570016, ENST00000219789, 
Fusion gene scores* DoF score6 X 9 X 5=2706 X 5 X 1=30
# samples 96
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCT5 [Title/Abstract] AND CDIPT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCT5(10263376)-CDIPT(29870570), # samples:1
Anticipated loss of major functional domain due to fusion event.CCT5-CDIPT seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CCT5-CDIPT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CCT5-CDIPT seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CCT5-CDIPT seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDIPT

GO:0006661

phosphatidylinositol biosynthetic process

8110188|9407135


check buttonFusion gene breakpoints across CCT5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CDIPT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE836096CCT5chr5

10263376

+CDIPTchr16

29870570

+


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Fusion Gene ORF analysis for CCT5-CDIPT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000280326ENST00000563415CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-3UTRENST00000503026ENST00000563415CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-3UTRENST00000506600ENST00000563415CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-3UTRENST00000515390ENST00000563415CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-3UTRENST00000515676ENST00000563415CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000280326ENST00000561555CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000280326ENST00000566113CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000280326ENST00000567459CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000280326ENST00000569956CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000280326ENST00000570016CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000503026ENST00000561555CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000503026ENST00000566113CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000503026ENST00000567459CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000503026ENST00000569956CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000503026ENST00000570016CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000506600ENST00000561555CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000506600ENST00000566113CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000506600ENST00000567459CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000506600ENST00000569956CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000506600ENST00000570016CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000515390ENST00000561555CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000515390ENST00000566113CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000515390ENST00000567459CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000515390ENST00000569956CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000515390ENST00000570016CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000515676ENST00000561555CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000515676ENST00000566113CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000515676ENST00000567459CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000515676ENST00000569956CCT5chr5

10263376

+CDIPTchr16

29870570

+
5CDS-5UTRENST00000515676ENST00000570016CCT5chr5

10263376

+CDIPTchr16

29870570

+
Frame-shiftENST00000280326ENST00000219789CCT5chr5

10263376

+CDIPTchr16

29870570

+
Frame-shiftENST00000503026ENST00000219789CCT5chr5

10263376

+CDIPTchr16

29870570

+
Frame-shiftENST00000506600ENST00000219789CCT5chr5

10263376

+CDIPTchr16

29870570

+
Frame-shiftENST00000515390ENST00000219789CCT5chr5

10263376

+CDIPTchr16

29870570

+
Frame-shiftENST00000515676ENST00000219789CCT5chr5

10263376

+CDIPTchr16

29870570

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CCT5-CDIPT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCT5-CDIPT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:10263376/:29870570)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCT5

P48643

CDIPT

O14735

FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.FUNCTION: Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. {ECO:0000269|PubMed:8110188, ECO:0000269|PubMed:9407135}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CCT5-CDIPT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CCT5-CDIPT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCT5-CDIPT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCT5-CDIPT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource