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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCT7-CCT7 (FusionGDB2 ID:14347)

Fusion Gene Summary for CCT7-CCT7

check button Fusion gene summary
Fusion gene informationFusion gene name: CCT7-CCT7
Fusion gene ID: 14347
HgeneTgene
Gene symbol

CCT7

CCT7

Gene ID

10574

10574

Gene namechaperonin containing TCP1 subunit 7chaperonin containing TCP1 subunit 7
SynonymsCCTETA|CCTH|NIP7-1|TCP1ETACCTETA|CCTH|NIP7-1|TCP1ETA
Cytomap

2p13.2

2p13.2

Type of geneprotein-codingprotein-coding
DescriptionT-complex protein 1 subunit etaCCT-etaHIV-1 Nef interacting proteinTCP-1-etachaperonin containing t-complex polypeptide 1, eta subunitT-complex protein 1 subunit etaCCT-etaHIV-1 Nef interacting proteinTCP-1-etachaperonin containing t-complex polypeptide 1, eta subunit
Modification date2020031320200313
UniProtAcc

Q99832

Q99832

Ensembl transtripts involved in fusion geneENST00000473786, ENST00000258091, 
ENST00000398422, ENST00000537131, 
ENST00000538797, ENST00000539919, 
ENST00000540468, 		ENST00000258091, 
ENST00000398422, ENST00000537131, 
ENST00000538797, ENST00000539919, 
ENST00000540468, ENST00000473786, 
Fusion gene scores* DoF score10 X 9 X 6=5407 X 9 X 3=189
# samples 129
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/189*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCT7 [Title/Abstract] AND CCT7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCT7(73475003)-CCT7(73476192), # samples:1
CCT7(73477010)-CCT7(73478406), # samples:1
Anticipated loss of major functional domain due to fusion event.CCT7-CCT7 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CCT7-CCT7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CCT7-CCT7 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CCT7-CCT7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CCT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCT7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA192763CCT7chr2

73475003

+CCT7chr2

73476192

-
ChiTaRS5.0N/ACV324589CCT7chr2

73477010

-CCT7chr2

73478406

+


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Fusion Gene ORF analysis for CCT7-CCT7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000473786ENST00000258091CCT7chr2

73475003

+CCT7chr2

73476192

-
3UTR-3CDSENST00000473786ENST00000398422CCT7chr2

73475003

+CCT7chr2

73476192

-
3UTR-3CDSENST00000473786ENST00000537131CCT7chr2

73475003

+CCT7chr2

73476192

-
3UTR-3CDSENST00000473786ENST00000538797CCT7chr2

73475003

+CCT7chr2

73476192

-
3UTR-3CDSENST00000473786ENST00000539919CCT7chr2

73475003

+CCT7chr2

73476192

-
3UTR-3CDSENST00000473786ENST00000540468CCT7chr2

73475003

+CCT7chr2

73476192

-
3UTR-3UTRENST00000473786ENST00000473786CCT7chr2

73475003

+CCT7chr2

73476192

-
5CDS-3UTRENST00000258091ENST00000473786CCT7chr2

73475003

+CCT7chr2

73476192

-
5CDS-3UTRENST00000398422ENST00000473786CCT7chr2

73475003

+CCT7chr2

73476192

-
5CDS-3UTRENST00000537131ENST00000473786CCT7chr2

73475003

+CCT7chr2

73476192

-
5CDS-3UTRENST00000538797ENST00000473786CCT7chr2

73475003

+CCT7chr2

73476192

-
5CDS-3UTRENST00000539919ENST00000473786CCT7chr2

73475003

+CCT7chr2

73476192

-
5CDS-3UTRENST00000540468ENST00000473786CCT7chr2

73475003

+CCT7chr2

73476192

-
5CDS-intronENST00000258091ENST00000473786CCT7chr2

73477010

-CCT7chr2

73478406

+
5CDS-intronENST00000398422ENST00000473786CCT7chr2

73477010

-CCT7chr2

73478406

+
5CDS-intronENST00000537131ENST00000473786CCT7chr2

73477010

-CCT7chr2

73478406

+
5CDS-intronENST00000538797ENST00000473786CCT7chr2

73477010

-CCT7chr2

73478406

+
5CDS-intronENST00000539919ENST00000473786CCT7chr2

73477010

-CCT7chr2

73478406

+
5CDS-intronENST00000540468ENST00000473786CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000258091ENST00000258091CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000258091ENST00000398422CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000258091ENST00000537131CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000258091ENST00000538797CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000258091ENST00000539919CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000258091ENST00000540468CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000398422ENST00000258091CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000398422ENST00000398422CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000398422ENST00000537131CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000398422ENST00000538797CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000398422ENST00000539919CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000398422ENST00000540468CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000537131ENST00000258091CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000537131ENST00000398422CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000537131ENST00000537131CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000537131ENST00000538797CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000537131ENST00000539919CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000537131ENST00000540468CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000538797ENST00000258091CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000538797ENST00000398422CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000538797ENST00000537131CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000538797ENST00000538797CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000538797ENST00000539919CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000538797ENST00000540468CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000539919ENST00000258091CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000539919ENST00000398422CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000539919ENST00000537131CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000539919ENST00000538797CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000539919ENST00000539919CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000539919ENST00000540468CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000540468ENST00000258091CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000540468ENST00000398422CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000540468ENST00000537131CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000540468ENST00000538797CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000540468ENST00000539919CCT7chr2

73477010

-CCT7chr2

73478406

+
Frame-shiftENST00000540468ENST00000540468CCT7chr2

73477010

-CCT7chr2

73478406

+
In-frameENST00000258091ENST00000258091CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000258091ENST00000398422CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000258091ENST00000537131CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000258091ENST00000538797CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000258091ENST00000539919CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000258091ENST00000540468CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000398422ENST00000258091CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000398422ENST00000398422CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000398422ENST00000537131CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000398422ENST00000538797CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000398422ENST00000539919CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000398422ENST00000540468CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000537131ENST00000258091CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000537131ENST00000398422CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000537131ENST00000537131CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000537131ENST00000538797CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000537131ENST00000539919CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000537131ENST00000540468CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000538797ENST00000258091CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000538797ENST00000398422CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000538797ENST00000537131CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000538797ENST00000538797CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000538797ENST00000539919CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000538797ENST00000540468CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000539919ENST00000258091CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000539919ENST00000398422CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000539919ENST00000537131CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000539919ENST00000538797CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000539919ENST00000539919CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000539919ENST00000540468CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000540468ENST00000258091CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000540468ENST00000398422CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000540468ENST00000537131CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000540468ENST00000538797CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000540468ENST00000539919CCT7chr2

73475003

+CCT7chr2

73476192

-
In-frameENST00000540468ENST00000540468CCT7chr2

73475003

+CCT7chr2

73476192

-
intron-3CDSENST00000473786ENST00000258091CCT7chr2

73477010

-CCT7chr2

73478406

+
intron-3CDSENST00000473786ENST00000398422CCT7chr2

73477010

-CCT7chr2

73478406

+
intron-3CDSENST00000473786ENST00000537131CCT7chr2

73477010

-CCT7chr2

73478406

+
intron-3CDSENST00000473786ENST00000538797CCT7chr2

73477010

-CCT7chr2

73478406

+
intron-3CDSENST00000473786ENST00000539919CCT7chr2

73477010

-CCT7chr2

73478406

+
intron-3CDSENST00000473786ENST00000540468CCT7chr2

73477010

-CCT7chr2

73478406

+
intron-intronENST00000473786ENST00000473786CCT7chr2

73477010

-CCT7chr2

73478406

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CCT7-CCT7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCT7-CCT7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:73475003/chr2:73476192)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCT7

Q99832

CCT7

Q99832

FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:25467444, ECO:0000305}.FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:25467444, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CCT7-CCT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CCT7-CCT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCT7-CCT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCT7-CCT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource