|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CCT8-LHX4 (FusionGDB2 ID:14358) |
Fusion Gene Summary for CCT8-LHX4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCT8-LHX4 | Fusion gene ID: 14358 | Hgene | Tgene | Gene symbol | CCT8 | LHX4 | Gene ID | 10694 | 89884 |
| Gene name | chaperonin containing TCP1 subunit 8 | LIM homeobox 4 | |
| Synonyms | C21orf112|Cctq|D21S246|PRED71 | CPHD4 | |
| Cytomap | 21q21.3 | 1q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | T-complex protein 1 subunit thetaCCT-thetaTCP-1-thetachaperonin containing T-complex polypeptide 1 subunit 8chaperonin containing TCP1, subunit 8 (theta)renal carcinoma antigen NY-REN-15 | LIM/homeobox protein Lhx4LIM homeobox protein 4 | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | P50990 | Q969G2 | |
| Ensembl transtripts involved in fusion gene | ENST00000470450, ENST00000286788, ENST00000540844, ENST00000542732, | ENST00000263726, | |
| Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 3 X 3 X 5=45 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/45*10)=0.637429920615292 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CCT8 [Title/Abstract] AND LHX4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CCT8(30432862)-LHX4(180217420), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | CCT8-LHX4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CCT8-LHX4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CCT8-LHX4 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. CCT8-LHX4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LHX4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15998782 |
| Fusion gene breakpoints across CCT8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across LHX4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-EW-A6SA-01A | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + |
| ChimerDB4 | BRCA | TCGA-EW-A6SA | CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + |
Top |
Fusion Gene ORF analysis for CCT8-LHX4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000470450 | ENST00000263726 | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + |
| 5UTR-3CDS | ENST00000470450 | ENST00000263726 | CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + |
| Frame-shift | ENST00000286788 | ENST00000263726 | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + |
| Frame-shift | ENST00000286788 | ENST00000263726 | CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + |
| Frame-shift | ENST00000540844 | ENST00000263726 | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + |
| Frame-shift | ENST00000540844 | ENST00000263726 | CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + |
| In-frame | ENST00000542732 | ENST00000263726 | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + |
| In-frame | ENST00000542732 | ENST00000263726 | CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000542732 | CCT8 | chr21 | 30432862 | - | ENST00000263726 | LHX4 | chr1 | 180217420 | + | 8401 | 1638 | 126 | 1691 | 521 |
| ENST00000542732 | CCT8 | chr21 | 30432861 | - | ENST00000263726 | LHX4 | chr1 | 180217419 | + | 8401 | 1638 | 126 | 1691 | 521 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000542732 | ENST00000263726 | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + | 0.002162237 | 0.99783784 |
| ENST00000542732 | ENST00000263726 | CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + | 0.002162237 | 0.99783784 |
Top |
Fusion Genomic Features for CCT8-LHX4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + | 0.000273467 | 0.9997265 |
| CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + | 0.000273467 | 0.9997265 |
| CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + | 0.000273467 | 0.9997265 |
| CCT8 | chr21 | 30432861 | - | LHX4 | chr1 | 180217419 | + | 0.000273467 | 0.9997265 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for CCT8-LHX4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:30432862/chr1:180217420) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCT8 | LHX4 |
| FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}. | FUNCTION: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250, ECO:0000269|PubMed:28473536}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | LHX4 | chr21:30432861 | chr1:180217419 | ENST00000263726 | 0 | 6 | 157_216 | 25 | 391.0 | DNA binding | Homeobox | |
| Tgene | LHX4 | chr21:30432862 | chr1:180217420 | ENST00000263726 | 0 | 6 | 157_216 | 25 | 391.0 | DNA binding | Homeobox | |
| Tgene | LHX4 | chr21:30432861 | chr1:180217419 | ENST00000263726 | 0 | 6 | 28_87 | 25 | 391.0 | Domain | LIM zinc-binding 1 | |
| Tgene | LHX4 | chr21:30432861 | chr1:180217419 | ENST00000263726 | 0 | 6 | 88_150 | 25 | 391.0 | Domain | LIM zinc-binding 2 | |
| Tgene | LHX4 | chr21:30432862 | chr1:180217420 | ENST00000263726 | 0 | 6 | 28_87 | 25 | 391.0 | Domain | LIM zinc-binding 1 | |
| Tgene | LHX4 | chr21:30432862 | chr1:180217420 | ENST00000263726 | 0 | 6 | 88_150 | 25 | 391.0 | Domain | LIM zinc-binding 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for CCT8-LHX4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >14358_14358_1_CCT8-LHX4_CCT8_chr21_30432861_ENST00000542732_LHX4_chr1_180217419_ENST00000263726_length(transcript)=8401nt_BP=1638nt ACTTCTCTTCTTCCGCGACCGGGAGAAGGCCGAGGGATCGGCGGCACGATCGACATTGTACACCTTGAAGGTGGACGGATGTGAAGCCGC GCGTTGTAGGGCTGAAGCTTACCAAAGAAAGGAAGAATGCACTTTTCAGGATTAGAAGAGGCTGTGTATAGAAACATACAAGCTTGCAAG GAGCTTGCCCAAACCACTCGTACAGCATATGGACCAAATGGAATGAACAAAATGGTTATCAACCACTTGGAGAAGTTGTTTGTGACAAAC GATGCAGCAACTATTTTAAGAGAACTAGAAGTACAGCATCCTGCTGCAAAAATGATTGTAATGGCTTCTCATATGCAAGAGCAAGAAGTT GGAGATGGCACAAACTTTGTTCTGGTATTTGCTGGAGCTCTCCTGGAATTAGCTGAAGAACTTCTGAGGATTGGCCTGTCAGTTTCAGAG GTCATAGAAGGTTATGAAATAGCCTGCAGAAAAGCTCATGAGATTCTTCCTAATTTGGTATGTTGTTCTGCAAAAAACCTTCGAGATATT GATGAAGTCTCATCTCTACTTCGTACCTCCATAATGAGTAAACAATATGGTAATGAAGTATTTCTGGCCAAGCTTATTGCTCAGGCATGC GTATCTATTTTTCCTGATTCCGGCCATTTCAATGTTGATAACATCAGAGTTTGTAAAATTCTGGGCTCTGGTATCAGTTCCTCTTCAGTA TTGCATGGCATGGTTTTTAAGAAGGAAACCGAAGGTGATGTAACATCTGTCAAAGATGCAAAAATAGCAGTGTACTCTTGTCCTTTTGAT GGCATGATAACAGAAACTAAGGGAACAGTGTTGATAAAGACTGCTGAAGAATTGATGAATTTTAGTAAGGGAGAAGAAAACCTCATGGAT GCACAAGTCAAAGCTATTGCTGATACTGGTGCAAATGTCGTAGTAACAGGTGGCAAAGTGGCAGACATGGCTCTTCATTATGCAAATAAA TATAATATCATGTTAGTGAGGCTAAACTCAAAATGGGATCTCCGAAGACTTTGTAAAACTGTTGGTGCTACAGCTCTTCCTAGATTGACA CCTCCTGTCCTTGAAGAAATGGGACACTGTGACAGTGTTTACCTCTCAGAAGTTGGAGATACTCAGGTGGTGGTTTTTAAGCATGAAAAG GAAGATGGCGCCATTTCTACCATAGTACTTCGAGGCTCTACAGACAATCTGATGGATGACATAGAAAGGGCAGTAGACGATGGTGTTAAT ACTTTCAAAGTTCTTACAAGGGATAAACGTCTTGTACCCGGAGGTGGAGCAACAGAAATTGAATTAGCCAAACAGATCACATCATATGGA GAGACATGTCCTGGACTTGAACAGTATGCTATTAAGAAGTTTGCTGAGGCATTTGAAGCTATTCCCCGCGCACTGGCAGAAAACTCTGGA GTTAAGGCCAATGAAGTAATCTCTAAACTTTATGCAGTACATCAAGAAGGAAATAAAAACGTTGGATTAGATATTGAGGCTGAAGTCCCT GCTGTAAAGGACATGCTGGAAGCTGGTATTCTAGATACTTACCTGGGAAAATATTGGGCTATCAAACTCGCTACTAATGCTGCAGTCACT GTACTTAGAGTGGATCAGAGATTCCCCAGTGCGCTGGCTGCAACCAGCACATCCTGGACAAGTTCATCCTGAAGGTCCTGGACAGACACT GGCACAGCTCCTGCCTCAAGTGTGCAGACTGCCAGATGCAGCTGGCGGACAGGTGCTTCTCCAGGGCTGGGAGCGTCTACTGCAAGGAGG ACTTCTTCAAGCGCTTCGGCACAAAATGCACGGCCTGCCAGCAGGGTATCCCCCCAACCCAGGTGGTCCGCAAGGCCCAGGACTTTGTCT ACCACCTGCACTGCTTTGCTTGCATCATCTGCAACCGGCAGCTGGCCACGGGGGACGAATTCTACCTCATGGAGGACGGGCGGCTGGTGT GCAAGGAAGACTACGAGACAGCCAAGCAGAACGATGACTCAGAGGCTGGAGCTAAGCGGCCCCGGACCACCATCACAGCCAAGCAGCTGG AGACATTAAAGAATGCATACAAGAACTCCCCCAAGCCTGCCCGGCACGTGAGGGAGCAGCTGTCCTCAGAGACAGGCCTGGACATGAGGG TCGTACAGGTTTGGTTTCAGAACAGAAGGGCCAAAGAGAAACGCCTGAAGAAGGATGCAGGGCGGCACCGCTGGGGGCAGTTCTATAAGA GCGTCAAGAGGAGCCGGGGCAGCAGCAAGCAGGAGAAGGAGAGCTCTGCAGAGGACTGTGGGGTTAGTGACAGTGAGCTGAGCTTCCGAG AGGATCAAATTCTCTCAGAACTTGGCCACACCAATAGGATTTATGGCAACGTGGGGGACGTTACAGGCGGACAGTTAATGAATGGGAGCT TCTCCATGGACGGGACAGGACAATCCTATCAGGACTTGAGGGATGGGAGCCCCTATGGAATCCCCCAGTCTCCATCCTCCATATCGTCCC TGCCATCCCACGCTCCTTTGCTCAATGGGCTGGATTACACGGTGGACAGTAATTTGGGCATCATTGCGCATGCAGGGCAGGGAGTAAGCC AGACGCTGAGAGCCATGGCTGGGGGACCCACCTCTGACATCTCCACAGGAAGCAGTGTAGGCTATCCCGACTTTCCAACTAGCCCAGGCT CTTGGCTCGATGAAATGGATCATCCTCCTTTTTAAACTTCTCTCCTCCCCACCCTACCTGCCCCCCTGGCTTGAGAGAATATCTTCAAGG ATCAAAAGAGACTTGCCTTTTAAGGATCGAAAGTACGCCAATGTGAATTTCCATTATTTTCAATGGAAGTCCTCCGCTGATTCCTAGAAG GCTGTGAGACCACACTAGGGCATTGTTTCCCTGGGGAAGCAGTGGGAGAGCAGACTCATCTCAGAACACAGCACAGGGGGTAATGGCCTA GAGCTCTAGGGACACTGGCTTGTTGGGTCTCTCCCCTGCTGTTCTGCTTAGGGGCTTGGCTGCTCAGTGCTTTGGTAGCACAAGGTGACT GTGATAGGCCCCCTTGGCCTTTGGGAACTTTGCTCCAACTGGTGTGTCTCACACAATGCCTCCCAAAACACTGCTCTCACCAGAACTGAG ACTCCTAAGGTAGAGGCCTCACAGCCCTTGAGTAAAATAAAAGTGATTTCTGGACCATCCTTATTGAACCCTATATTTCAAAATGAAAAG ATCAGTTATTAAAGGTCAGTGAACACTTTGATGGCCAGTTTGATATTAAAAACATGCCCCCTCCTTTTTTATTTTTGCTGTGAAGATATG AATTCTTTCCTACAAACCAGAGAATATGAACCTGTTTTGGTTTTTAAGTGTCCCATCTATATCATTGACTCTGATGGCAAGAGGTGGTTT TCATTGCAGGTGACTGAGGCTGAGCTGAGTAGCCCTGGACCACCGCTGCAGATTGCCTGAGTCGTCCCCTTGGTGCACAGTGTGCCTTCT TCAATTGCTTGTATCATTTATTCCACAAGACAGGCTGTGGGCTGTAAAATGAGCAAAACTAAAATGTGGGGAGAACAAAATGACAATCAA TCAGTGAACATTTGTAGACACATTTGGATTCCAAACCTGCAGTCTGTTCAGCCATATCGGCTGATGCCAGTCTTCCAGAGTTCCCCATCC CTTGTAGGGTGAAATATTTGGAGTCTGTTTTGAAGGAGTTGGTTTAGATGAGCTTGCAAGTCTACCCCTCTGAAAGCTTTCTCTGCTGTC CTAGCTGACTCAATTGGAGGACAGTTTTGGTCATTTCCAGGAACCAGCAATTTTTTTTTGGCCTACCTTGGTTGGGAAGAGTAATTTAGG GAGCAGCCCTAAAATTGTCCAAAGGGTTCTAAGTGGTTCTTGGGCTGCATCTCTCTGGATTGCTGGCTGGACACCTGCCATGCCTTGGGC TGCAGTCCCATGGTCAGAAAGCCAGAACTCTCTGGCCAGTGGTGGTGCAGGGACTCCCCGTTGTGCAGGTTTGCAGTAGCAAATCACTAA GCCTGAGGCCAGAGCAAGGCCAACCCCCGCTTTACGAGTTGCCACTCCTGCGACAGACTGCACTGCTGTGGGAAACGCTGTCCTGAATGG TGCTGCAGCTCCCACCCACCTTGTGCACCCATCTACCATCAGGAAGCTCTCCATGTGCAAACTGGAATTTAGCCAGCTGGAATTTATTCC TGTCCCTCTGGGAAGCTGTGTTTGCTTCTTCTGGCCTCCCATTCTCTTAAATGAGATCAGCAGAGTAGGAAAGGGTGAGAAGGCATTGCC TATCACATGAAGTGATGGGGCCAGAGACCCTAAGGACCCTTCCTTCTACGAATGGTTGGTCACCTTTTGAGGACTGCAAAGACTTAGGCA TGTCATAGGCAGACTAAAGGAAGAATACACAGTTCCTCTTGGACTGCTACATCTTTTGTAAGCCCTTTTCCAGGACTAAACTAAGTTCAA TTAAGTAAGTTCTTTAAAACAGTAAATTCCGGGATCAGCCTTCGGGCCCTCTTCTCTGACCAATTTTATAGCGTACCCTCGTTTTTTGGT GTGCTGCAGTGGTCATGATTTTTGCTTGAGAAGTCTGCAAACATAGACACTTCTCTTGAGGTTCCATGTTTATGGATGATGTTGTGTTAA TCCTAGCCAATTCTGTGCTATTGGGAATTCTCCAATCATGAACACTGGGGTGGGGAGGAAGACACAAATGCCATGTGAGGAAAGGAAAAT GCAGTCGTCTTTTTGGAGGATGGCTTTTTAAATACACCCTTCTTAGCAGGCTGCTTAAAATACACAGGAGAAAAGGCTCTGCTGGGCAAT GAACCAGATGAAAAGCTGCCCACCCAGATCACTGTTGCAGGTTGACTATTTGGCTTAGCAACTCATGGGATTTCAGAGGCCCTTGAAGTT TTTGGTGAGTATAGTGTGGGGGAGAGCAGGCTTTTTAAAAGGGGGGGGGGCATCCTCCTCTGTGTAGCACTGTTTAAGATCACTGTAAGT AAGTTGACCAGTTTTTGTAAGTTAATCATACTAATTCCCAGTTCAATAGTGGAAGGAGAGGCCTTCCTCATTTATACTAATAATATAATA AATCTCTTGAGGAACTCAGTGAGCAGTTGACGAGGTCAATAGTTCTTTGGCATCAGTAGGGCTGGTTAGCTGGAAAAACCCTTGAGAGCA CTGGCCTGAAAACCAGGAGAGCTTTGTTTTCCAGAGCCACCTCCCCAGAAAGCAGCAAACACTGCTGCCTGTTTAGAAGCACAGCCACAG TAGGTCTAAGATTTTAAATGGATCTCCCTACAGGTTGGGTTAGCATTATGGGTGGGCTGGTGCCACTAATGAGCCATTGCATGACAGGAC TCTTCTGGGGTTTGGAAATGGAGAAAAGCCGGGCATTCATTACTTTTAGCTTCTCTTAGAGGCACTCCTCTGTTGCTTGGAAGTCTATTA TGGGGTATAAGGTGCTACATGGTAGCTGTTTCCCCCCTTGCTAAAATGACATGGATGAATTTTAAAAATGAAATGAGACCTTCTAGAGGC AACCATTATCTGCAGTGCCTGGCTGGTCGACTTTAGAGTAGGAAGCTCTTGAATCCAGGAGCAAATTAGTTAAAACCCCAAGTTCCAGTG GTAACTGGTATAAGCAAAATGGAAACTGAGGGGCTATGGAGGAATCTCTGTTTGTTGGAACGTAATGAAACCATGGAGGAAATACCAGAT TTAAGGGCTAAGAAGCTGGCCCGATGGGTAAATCAGTGTTGGGAGTCAGGTTCTTGGCCCTTCAAGGACTTGCTATGCAACCTCAGGCAA ATTCCTCTCAGTCTTTGTGCTTTCTCTTTCTTGTCTCATCTGACAGTTATGAATATAACGTAAAATAAAGATCAACTATCATTGATAACA CTGTTCCTGCAAATGAATACTGTGAAACATCAGGGAAAGAGGAAAAAATTAAGCCACAAGAAAACCATTTGGCAGTGTCCTTAAACTTTT TTTGGGGGGGGGCAGTGTAAAACATGAAACCTAGTAAGATAATTGGGCCATTAGATCTTCATCATTAAACTCACTTTGCAAGGAAGTGTA AGAAATCTGTAAAACAAAAGACATTCCTATCTCAGAAGCTCAAACTGGTGATTTCCAACTGCCTCTTTACAGGAGGGGGCTCAAGGCTTC TGATGAGCAAAGGCTGTGTGTTGTATGACAGTCCACTCTCTGCACCTACACTTCCACGTGCCACGACTGACAACTTGGTTATAACCATGA AAATAATGACCATACCTCCCCAGCCAGCAGGGTCTGGAAGGCCTGAGGAGGCTCATTTTTAAACACTGCACTTTAAAAATTGGAAACCGT GAGATGAAGAAAAATTCAATTAAGCGGAAATGAGTTTTGTTTTATTGCCTGCTGCTGAAGGGCTCTGGGCATGCTGAAAGCTAAATGAAA AGCACATCACTGGCTCTCTTCTTTCTTGGATTGGTCAATTGGCCCTTTTTGCAGTAGTTGCTCCAACTGTTCTAAACAGTGAGTGACTGG AGCCAAAAAGAGAGAGCTCAGCAAAGCCATCCCATCCACACTCTGCTTGGTAGGACCACACTAAAAGCACAGTTTCATGCTGCTAGCTCT GGTAAGGAGACAGCTGCAGGTTTGGGAGGTGCACCAAGCATTCCTTTGCTTAGGGAGGCAGAGCACAGGTGAACAGAGGAAGGACACCCC CACTCTCATCTATTGCCCACCGAGAGGCAAGAATCACACCAACTTTCCCACTTGAGGACTGTGTTCGGCCAAACAAGCAGGTTCAGGGCT GCGGGATTCCAGAAGTTGCTCTGAGCTTGCAATCAGACCTCAAAGCCCCAGATCCCCTCAGCTCTGGATCGTTGCCCTCATCCTTCACAA TGTAAATTTTGTACAGTTAAAGAGAAATGAAGTCTCGTTTCCTGGGGAAAAAAAAGAAAAAAAGAAAAAAAAAAGACCCACCCATCCTTA TTTATTGCCATATGACTTTGGAAAACAGAAGCTGGTGCGTTTGTTTGTATATGCCTCCTGTGTGTTGGCATGAGATGTGTACGGTAAAAT TATGTAAAATAAATATGGAAATTCTTTAGATGCTGATGTGTCTTGCTTTTCATTTGGTTTGCTGGAAGTTTTTTCTCTTGACATAAATAG AATAAAAACTGAGTGATGTGAGGTCCTTTCCTTTTATCATCAGAAGGAAACCAAATATACAACTCTGAATGCCAGAACTATTATACTTAG AGCCATGAAATACCAGAACCACTCAATAAAGGACTGATTAGAGGAAGTTCCCTGGTTTTTCTAATAGTCATTTCCTGGGCACGATCCTCT GCCCCCAGACTTAGGAAATGAGCAGTAGAAATGTTGACCATATAACTTTTAGTTCCTGTTTGTTCAGTGGCATTTTTAAAATTTTTTTTT GAGACAGAGTCTTGCGCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCTGCTTCCTGGGTTCGAGTGATTT TCGTGCCTCAGCCTCCAGAGTACGTGGGATTACAGGCATGCGCAAACACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTT GCCACGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCGCCCACCTGGGCCTCCCAAAGTGCTGGAATTACAGGTGTGAGCC ACCATGCCCGGCCTGTCCAGTAGCATTTTAAAAGTCCTTCACACTCATACATTTTTCTTTCTAGAGAAAGTATATGCAAATGTCTATATT TACAGAGGGACAGAAACACCTCATCAGAGTCATCAGGGCTCCTGGACAAACATTTTCCAGGAGAATCTCCATTTAGGTTTGTTTTCTCTG CAGGAGTCTTTATTAGTGTGCAGACCCTAAGTTTAGCTGGAATGGAAACAGCAACAGGGACTTTTTCATTACATTAAAAAAAAAAAAAGT CATAGCATTTCTTTACAGCTGGGATTCCACTGTGGAAAAACTACAGCGTGTTTCTTTTCCCCACTAGTCATTAGTTTTGTTTGGCTGAAG AGAAGATCCAAAGCAGTGGCACTGTCCAATATGGTAGCTACTAGCCACACATGGCTATTTAAATTTAAATTAGTATTAAATAAAACTAAA AGTTTAGTTCCTTACACTAGACACATTTTAGGTGCTCAACAGCTTCATGTGACCAGTGGCTACTGTATTTGGACGACACTGATATAAAAC AGTTCTATCATTGCAGATGGCTCTACTGGACGGTGCTCATAGAGTCTTGTTAGGGAGAGTGGGCAAGGAAATCTCATTCATCACATGTTT >14358_14358_1_CCT8-LHX4_CCT8_chr21_30432861_ENST00000542732_LHX4_chr1_180217419_ENST00000263726_length(amino acids)=521AA_BP=503 MHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAG ALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNV DNIRVCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGAN VVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRG STDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYA -------------------------------------------------------------- >14358_14358_2_CCT8-LHX4_CCT8_chr21_30432862_ENST00000542732_LHX4_chr1_180217420_ENST00000263726_length(transcript)=8401nt_BP=1638nt ACTTCTCTTCTTCCGCGACCGGGAGAAGGCCGAGGGATCGGCGGCACGATCGACATTGTACACCTTGAAGGTGGACGGATGTGAAGCCGC GCGTTGTAGGGCTGAAGCTTACCAAAGAAAGGAAGAATGCACTTTTCAGGATTAGAAGAGGCTGTGTATAGAAACATACAAGCTTGCAAG GAGCTTGCCCAAACCACTCGTACAGCATATGGACCAAATGGAATGAACAAAATGGTTATCAACCACTTGGAGAAGTTGTTTGTGACAAAC GATGCAGCAACTATTTTAAGAGAACTAGAAGTACAGCATCCTGCTGCAAAAATGATTGTAATGGCTTCTCATATGCAAGAGCAAGAAGTT GGAGATGGCACAAACTTTGTTCTGGTATTTGCTGGAGCTCTCCTGGAATTAGCTGAAGAACTTCTGAGGATTGGCCTGTCAGTTTCAGAG GTCATAGAAGGTTATGAAATAGCCTGCAGAAAAGCTCATGAGATTCTTCCTAATTTGGTATGTTGTTCTGCAAAAAACCTTCGAGATATT GATGAAGTCTCATCTCTACTTCGTACCTCCATAATGAGTAAACAATATGGTAATGAAGTATTTCTGGCCAAGCTTATTGCTCAGGCATGC GTATCTATTTTTCCTGATTCCGGCCATTTCAATGTTGATAACATCAGAGTTTGTAAAATTCTGGGCTCTGGTATCAGTTCCTCTTCAGTA TTGCATGGCATGGTTTTTAAGAAGGAAACCGAAGGTGATGTAACATCTGTCAAAGATGCAAAAATAGCAGTGTACTCTTGTCCTTTTGAT GGCATGATAACAGAAACTAAGGGAACAGTGTTGATAAAGACTGCTGAAGAATTGATGAATTTTAGTAAGGGAGAAGAAAACCTCATGGAT GCACAAGTCAAAGCTATTGCTGATACTGGTGCAAATGTCGTAGTAACAGGTGGCAAAGTGGCAGACATGGCTCTTCATTATGCAAATAAA TATAATATCATGTTAGTGAGGCTAAACTCAAAATGGGATCTCCGAAGACTTTGTAAAACTGTTGGTGCTACAGCTCTTCCTAGATTGACA CCTCCTGTCCTTGAAGAAATGGGACACTGTGACAGTGTTTACCTCTCAGAAGTTGGAGATACTCAGGTGGTGGTTTTTAAGCATGAAAAG GAAGATGGCGCCATTTCTACCATAGTACTTCGAGGCTCTACAGACAATCTGATGGATGACATAGAAAGGGCAGTAGACGATGGTGTTAAT ACTTTCAAAGTTCTTACAAGGGATAAACGTCTTGTACCCGGAGGTGGAGCAACAGAAATTGAATTAGCCAAACAGATCACATCATATGGA GAGACATGTCCTGGACTTGAACAGTATGCTATTAAGAAGTTTGCTGAGGCATTTGAAGCTATTCCCCGCGCACTGGCAGAAAACTCTGGA GTTAAGGCCAATGAAGTAATCTCTAAACTTTATGCAGTACATCAAGAAGGAAATAAAAACGTTGGATTAGATATTGAGGCTGAAGTCCCT GCTGTAAAGGACATGCTGGAAGCTGGTATTCTAGATACTTACCTGGGAAAATATTGGGCTATCAAACTCGCTACTAATGCTGCAGTCACT GTACTTAGAGTGGATCAGAGATTCCCCAGTGCGCTGGCTGCAACCAGCACATCCTGGACAAGTTCATCCTGAAGGTCCTGGACAGACACT GGCACAGCTCCTGCCTCAAGTGTGCAGACTGCCAGATGCAGCTGGCGGACAGGTGCTTCTCCAGGGCTGGGAGCGTCTACTGCAAGGAGG ACTTCTTCAAGCGCTTCGGCACAAAATGCACGGCCTGCCAGCAGGGTATCCCCCCAACCCAGGTGGTCCGCAAGGCCCAGGACTTTGTCT ACCACCTGCACTGCTTTGCTTGCATCATCTGCAACCGGCAGCTGGCCACGGGGGACGAATTCTACCTCATGGAGGACGGGCGGCTGGTGT GCAAGGAAGACTACGAGACAGCCAAGCAGAACGATGACTCAGAGGCTGGAGCTAAGCGGCCCCGGACCACCATCACAGCCAAGCAGCTGG AGACATTAAAGAATGCATACAAGAACTCCCCCAAGCCTGCCCGGCACGTGAGGGAGCAGCTGTCCTCAGAGACAGGCCTGGACATGAGGG TCGTACAGGTTTGGTTTCAGAACAGAAGGGCCAAAGAGAAACGCCTGAAGAAGGATGCAGGGCGGCACCGCTGGGGGCAGTTCTATAAGA GCGTCAAGAGGAGCCGGGGCAGCAGCAAGCAGGAGAAGGAGAGCTCTGCAGAGGACTGTGGGGTTAGTGACAGTGAGCTGAGCTTCCGAG AGGATCAAATTCTCTCAGAACTTGGCCACACCAATAGGATTTATGGCAACGTGGGGGACGTTACAGGCGGACAGTTAATGAATGGGAGCT TCTCCATGGACGGGACAGGACAATCCTATCAGGACTTGAGGGATGGGAGCCCCTATGGAATCCCCCAGTCTCCATCCTCCATATCGTCCC TGCCATCCCACGCTCCTTTGCTCAATGGGCTGGATTACACGGTGGACAGTAATTTGGGCATCATTGCGCATGCAGGGCAGGGAGTAAGCC AGACGCTGAGAGCCATGGCTGGGGGACCCACCTCTGACATCTCCACAGGAAGCAGTGTAGGCTATCCCGACTTTCCAACTAGCCCAGGCT CTTGGCTCGATGAAATGGATCATCCTCCTTTTTAAACTTCTCTCCTCCCCACCCTACCTGCCCCCCTGGCTTGAGAGAATATCTTCAAGG ATCAAAAGAGACTTGCCTTTTAAGGATCGAAAGTACGCCAATGTGAATTTCCATTATTTTCAATGGAAGTCCTCCGCTGATTCCTAGAAG GCTGTGAGACCACACTAGGGCATTGTTTCCCTGGGGAAGCAGTGGGAGAGCAGACTCATCTCAGAACACAGCACAGGGGGTAATGGCCTA GAGCTCTAGGGACACTGGCTTGTTGGGTCTCTCCCCTGCTGTTCTGCTTAGGGGCTTGGCTGCTCAGTGCTTTGGTAGCACAAGGTGACT GTGATAGGCCCCCTTGGCCTTTGGGAACTTTGCTCCAACTGGTGTGTCTCACACAATGCCTCCCAAAACACTGCTCTCACCAGAACTGAG ACTCCTAAGGTAGAGGCCTCACAGCCCTTGAGTAAAATAAAAGTGATTTCTGGACCATCCTTATTGAACCCTATATTTCAAAATGAAAAG ATCAGTTATTAAAGGTCAGTGAACACTTTGATGGCCAGTTTGATATTAAAAACATGCCCCCTCCTTTTTTATTTTTGCTGTGAAGATATG AATTCTTTCCTACAAACCAGAGAATATGAACCTGTTTTGGTTTTTAAGTGTCCCATCTATATCATTGACTCTGATGGCAAGAGGTGGTTT TCATTGCAGGTGACTGAGGCTGAGCTGAGTAGCCCTGGACCACCGCTGCAGATTGCCTGAGTCGTCCCCTTGGTGCACAGTGTGCCTTCT TCAATTGCTTGTATCATTTATTCCACAAGACAGGCTGTGGGCTGTAAAATGAGCAAAACTAAAATGTGGGGAGAACAAAATGACAATCAA TCAGTGAACATTTGTAGACACATTTGGATTCCAAACCTGCAGTCTGTTCAGCCATATCGGCTGATGCCAGTCTTCCAGAGTTCCCCATCC CTTGTAGGGTGAAATATTTGGAGTCTGTTTTGAAGGAGTTGGTTTAGATGAGCTTGCAAGTCTACCCCTCTGAAAGCTTTCTCTGCTGTC CTAGCTGACTCAATTGGAGGACAGTTTTGGTCATTTCCAGGAACCAGCAATTTTTTTTTGGCCTACCTTGGTTGGGAAGAGTAATTTAGG GAGCAGCCCTAAAATTGTCCAAAGGGTTCTAAGTGGTTCTTGGGCTGCATCTCTCTGGATTGCTGGCTGGACACCTGCCATGCCTTGGGC TGCAGTCCCATGGTCAGAAAGCCAGAACTCTCTGGCCAGTGGTGGTGCAGGGACTCCCCGTTGTGCAGGTTTGCAGTAGCAAATCACTAA GCCTGAGGCCAGAGCAAGGCCAACCCCCGCTTTACGAGTTGCCACTCCTGCGACAGACTGCACTGCTGTGGGAAACGCTGTCCTGAATGG TGCTGCAGCTCCCACCCACCTTGTGCACCCATCTACCATCAGGAAGCTCTCCATGTGCAAACTGGAATTTAGCCAGCTGGAATTTATTCC TGTCCCTCTGGGAAGCTGTGTTTGCTTCTTCTGGCCTCCCATTCTCTTAAATGAGATCAGCAGAGTAGGAAAGGGTGAGAAGGCATTGCC TATCACATGAAGTGATGGGGCCAGAGACCCTAAGGACCCTTCCTTCTACGAATGGTTGGTCACCTTTTGAGGACTGCAAAGACTTAGGCA TGTCATAGGCAGACTAAAGGAAGAATACACAGTTCCTCTTGGACTGCTACATCTTTTGTAAGCCCTTTTCCAGGACTAAACTAAGTTCAA TTAAGTAAGTTCTTTAAAACAGTAAATTCCGGGATCAGCCTTCGGGCCCTCTTCTCTGACCAATTTTATAGCGTACCCTCGTTTTTTGGT GTGCTGCAGTGGTCATGATTTTTGCTTGAGAAGTCTGCAAACATAGACACTTCTCTTGAGGTTCCATGTTTATGGATGATGTTGTGTTAA TCCTAGCCAATTCTGTGCTATTGGGAATTCTCCAATCATGAACACTGGGGTGGGGAGGAAGACACAAATGCCATGTGAGGAAAGGAAAAT GCAGTCGTCTTTTTGGAGGATGGCTTTTTAAATACACCCTTCTTAGCAGGCTGCTTAAAATACACAGGAGAAAAGGCTCTGCTGGGCAAT GAACCAGATGAAAAGCTGCCCACCCAGATCACTGTTGCAGGTTGACTATTTGGCTTAGCAACTCATGGGATTTCAGAGGCCCTTGAAGTT TTTGGTGAGTATAGTGTGGGGGAGAGCAGGCTTTTTAAAAGGGGGGGGGGCATCCTCCTCTGTGTAGCACTGTTTAAGATCACTGTAAGT AAGTTGACCAGTTTTTGTAAGTTAATCATACTAATTCCCAGTTCAATAGTGGAAGGAGAGGCCTTCCTCATTTATACTAATAATATAATA AATCTCTTGAGGAACTCAGTGAGCAGTTGACGAGGTCAATAGTTCTTTGGCATCAGTAGGGCTGGTTAGCTGGAAAAACCCTTGAGAGCA CTGGCCTGAAAACCAGGAGAGCTTTGTTTTCCAGAGCCACCTCCCCAGAAAGCAGCAAACACTGCTGCCTGTTTAGAAGCACAGCCACAG TAGGTCTAAGATTTTAAATGGATCTCCCTACAGGTTGGGTTAGCATTATGGGTGGGCTGGTGCCACTAATGAGCCATTGCATGACAGGAC TCTTCTGGGGTTTGGAAATGGAGAAAAGCCGGGCATTCATTACTTTTAGCTTCTCTTAGAGGCACTCCTCTGTTGCTTGGAAGTCTATTA TGGGGTATAAGGTGCTACATGGTAGCTGTTTCCCCCCTTGCTAAAATGACATGGATGAATTTTAAAAATGAAATGAGACCTTCTAGAGGC AACCATTATCTGCAGTGCCTGGCTGGTCGACTTTAGAGTAGGAAGCTCTTGAATCCAGGAGCAAATTAGTTAAAACCCCAAGTTCCAGTG GTAACTGGTATAAGCAAAATGGAAACTGAGGGGCTATGGAGGAATCTCTGTTTGTTGGAACGTAATGAAACCATGGAGGAAATACCAGAT TTAAGGGCTAAGAAGCTGGCCCGATGGGTAAATCAGTGTTGGGAGTCAGGTTCTTGGCCCTTCAAGGACTTGCTATGCAACCTCAGGCAA ATTCCTCTCAGTCTTTGTGCTTTCTCTTTCTTGTCTCATCTGACAGTTATGAATATAACGTAAAATAAAGATCAACTATCATTGATAACA CTGTTCCTGCAAATGAATACTGTGAAACATCAGGGAAAGAGGAAAAAATTAAGCCACAAGAAAACCATTTGGCAGTGTCCTTAAACTTTT TTTGGGGGGGGGCAGTGTAAAACATGAAACCTAGTAAGATAATTGGGCCATTAGATCTTCATCATTAAACTCACTTTGCAAGGAAGTGTA AGAAATCTGTAAAACAAAAGACATTCCTATCTCAGAAGCTCAAACTGGTGATTTCCAACTGCCTCTTTACAGGAGGGGGCTCAAGGCTTC TGATGAGCAAAGGCTGTGTGTTGTATGACAGTCCACTCTCTGCACCTACACTTCCACGTGCCACGACTGACAACTTGGTTATAACCATGA AAATAATGACCATACCTCCCCAGCCAGCAGGGTCTGGAAGGCCTGAGGAGGCTCATTTTTAAACACTGCACTTTAAAAATTGGAAACCGT GAGATGAAGAAAAATTCAATTAAGCGGAAATGAGTTTTGTTTTATTGCCTGCTGCTGAAGGGCTCTGGGCATGCTGAAAGCTAAATGAAA AGCACATCACTGGCTCTCTTCTTTCTTGGATTGGTCAATTGGCCCTTTTTGCAGTAGTTGCTCCAACTGTTCTAAACAGTGAGTGACTGG AGCCAAAAAGAGAGAGCTCAGCAAAGCCATCCCATCCACACTCTGCTTGGTAGGACCACACTAAAAGCACAGTTTCATGCTGCTAGCTCT GGTAAGGAGACAGCTGCAGGTTTGGGAGGTGCACCAAGCATTCCTTTGCTTAGGGAGGCAGAGCACAGGTGAACAGAGGAAGGACACCCC CACTCTCATCTATTGCCCACCGAGAGGCAAGAATCACACCAACTTTCCCACTTGAGGACTGTGTTCGGCCAAACAAGCAGGTTCAGGGCT GCGGGATTCCAGAAGTTGCTCTGAGCTTGCAATCAGACCTCAAAGCCCCAGATCCCCTCAGCTCTGGATCGTTGCCCTCATCCTTCACAA TGTAAATTTTGTACAGTTAAAGAGAAATGAAGTCTCGTTTCCTGGGGAAAAAAAAGAAAAAAAGAAAAAAAAAAGACCCACCCATCCTTA TTTATTGCCATATGACTTTGGAAAACAGAAGCTGGTGCGTTTGTTTGTATATGCCTCCTGTGTGTTGGCATGAGATGTGTACGGTAAAAT TATGTAAAATAAATATGGAAATTCTTTAGATGCTGATGTGTCTTGCTTTTCATTTGGTTTGCTGGAAGTTTTTTCTCTTGACATAAATAG AATAAAAACTGAGTGATGTGAGGTCCTTTCCTTTTATCATCAGAAGGAAACCAAATATACAACTCTGAATGCCAGAACTATTATACTTAG AGCCATGAAATACCAGAACCACTCAATAAAGGACTGATTAGAGGAAGTTCCCTGGTTTTTCTAATAGTCATTTCCTGGGCACGATCCTCT GCCCCCAGACTTAGGAAATGAGCAGTAGAAATGTTGACCATATAACTTTTAGTTCCTGTTTGTTCAGTGGCATTTTTAAAATTTTTTTTT GAGACAGAGTCTTGCGCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCTGCTTCCTGGGTTCGAGTGATTT TCGTGCCTCAGCCTCCAGAGTACGTGGGATTACAGGCATGCGCAAACACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTT GCCACGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCGCCCACCTGGGCCTCCCAAAGTGCTGGAATTACAGGTGTGAGCC ACCATGCCCGGCCTGTCCAGTAGCATTTTAAAAGTCCTTCACACTCATACATTTTTCTTTCTAGAGAAAGTATATGCAAATGTCTATATT TACAGAGGGACAGAAACACCTCATCAGAGTCATCAGGGCTCCTGGACAAACATTTTCCAGGAGAATCTCCATTTAGGTTTGTTTTCTCTG CAGGAGTCTTTATTAGTGTGCAGACCCTAAGTTTAGCTGGAATGGAAACAGCAACAGGGACTTTTTCATTACATTAAAAAAAAAAAAAGT CATAGCATTTCTTTACAGCTGGGATTCCACTGTGGAAAAACTACAGCGTGTTTCTTTTCCCCACTAGTCATTAGTTTTGTTTGGCTGAAG AGAAGATCCAAAGCAGTGGCACTGTCCAATATGGTAGCTACTAGCCACACATGGCTATTTAAATTTAAATTAGTATTAAATAAAACTAAA AGTTTAGTTCCTTACACTAGACACATTTTAGGTGCTCAACAGCTTCATGTGACCAGTGGCTACTGTATTTGGACGACACTGATATAAAAC AGTTCTATCATTGCAGATGGCTCTACTGGACGGTGCTCATAGAGTCTTGTTAGGGAGAGTGGGCAAGGAAATCTCATTCATCACATGTTT >14358_14358_2_CCT8-LHX4_CCT8_chr21_30432862_ENST00000542732_LHX4_chr1_180217420_ENST00000263726_length(amino acids)=521AA_BP=503 MHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAG ALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNV DNIRVCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGAN VVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRG STDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYA -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for CCT8-LHX4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | LHX4 | chr21:30432861 | chr1:180217419 | ENST00000263726 | 0 | 6 | 199_211 | 25.333333333333332 | 391.0 | 5-mCpG DNA | |
| Tgene | LHX4 | chr21:30432862 | chr1:180217420 | ENST00000263726 | 0 | 6 | 199_211 | 25.333333333333332 | 391.0 | 5-mCpG DNA | |
| Tgene | LHX4 | chr21:30432861 | chr1:180217419 | ENST00000263726 | 0 | 6 | 161_181 | 25.333333333333332 | 391.0 | DNA | |
| Tgene | LHX4 | chr21:30432862 | chr1:180217420 | ENST00000263726 | 0 | 6 | 161_181 | 25.333333333333332 | 391.0 | DNA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for CCT8-LHX4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for CCT8-LHX4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies