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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD276-CD276 (FusionGDB2 ID:14434)

Fusion Gene Summary for CD276-CD276

check button Fusion gene summary
Fusion gene informationFusion gene name: CD276-CD276
Fusion gene ID: 14434
HgeneTgene
Gene symbol

CD276

CD276

Gene ID

80381

80381

Gene nameCD276 moleculeCD276 molecule
Synonyms4Ig-B7-H3|B7-H3|B7H3|B7RP-24Ig-B7-H3|B7-H3|B7H3|B7RP-2
Cytomap

15q24.1

15q24.1

Type of geneprotein-codingprotein-coding
DescriptionCD276 antigenB7 homolog 3costimulatory moleculeCD276 antigenB7 homolog 3costimulatory molecule
Modification date2020031320200313
UniProtAcc

Q5ZPR3

Q5ZPR3

Ensembl transtripts involved in fusion geneENST00000318424, ENST00000318443, 
ENST00000537340, ENST00000561213, 
ENST00000564751, 		ENST00000318424, 
ENST00000537340, ENST00000561213, 
ENST00000564751, ENST00000318443, 
Fusion gene scores* DoF score7 X 6 X 3=1265 X 5 X 3=75
# samples 85
** MAII scorelog2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD276 [Title/Abstract] AND CD276 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD276(73996814)-CD276(73994589), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD276

GO:0042102

positive regulation of T cell proliferation

11224528

HgeneCD276

GO:0042110

T cell activation

18650384

HgeneCD276

GO:0045078

positive regulation of interferon-gamma biosynthetic process

11224528

TgeneCD276

GO:0042102

positive regulation of T cell proliferation

11224528

TgeneCD276

GO:0042110

T cell activation

18650384

TgeneCD276

GO:0045078

positive regulation of interferon-gamma biosynthetic process

11224528


check buttonFusion gene breakpoints across CD276 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CD276 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG574312CD276chr15

73996814

+CD276chr15

73994589

+


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Fusion Gene ORF analysis for CD276-CD276

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000318424ENST00000318424CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000318424ENST00000537340CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000318424ENST00000561213CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000318424ENST00000564751CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000318443ENST00000318424CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000318443ENST00000537340CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000318443ENST00000561213CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000318443ENST00000564751CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000537340ENST00000318424CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000537340ENST00000537340CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000537340ENST00000561213CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000537340ENST00000564751CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000561213ENST00000318424CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000561213ENST00000537340CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000561213ENST00000561213CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000561213ENST00000564751CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000564751ENST00000318424CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000564751ENST00000537340CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000564751ENST00000561213CD276chr15

73996814

+CD276chr15

73994589

+
5CDS-5UTRENST00000564751ENST00000564751CD276chr15

73996814

+CD276chr15

73994589

+
In-frameENST00000318424ENST00000318443CD276chr15

73996814

+CD276chr15

73994589

+
In-frameENST00000318443ENST00000318443CD276chr15

73996814

+CD276chr15

73994589

+
In-frameENST00000537340ENST00000318443CD276chr15

73996814

+CD276chr15

73994589

+
In-frameENST00000561213ENST00000318443CD276chr15

73996814

+CD276chr15

73994589

+
In-frameENST00000564751ENST00000318443CD276chr15

73996814

+CD276chr15

73994589

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CD276-CD276


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CD276chr1573996813+CD276chr1573994595+0.0001156990.99988425
CD276chr1573996813+CD276chr1573994595+0.0001156990.99988425

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CD276-CD276


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:73996814/chr15:73994589)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD276

Q5ZPR3

CD276

Q5ZPR3

FUNCTION: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}.FUNCTION: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD276chr15:73996814chr15:73994589ENST00000318424+48145_238238317.0DomainNote=Ig-like C2-type 1
HgeneCD276chr15:73996814chr15:73994589ENST00000318424+4829_139238317.0DomainNote=Ig-like V-type 1
HgeneCD276chr15:73996814chr15:73994589ENST00000318443+610145_238456535.0DomainNote=Ig-like C2-type 1
HgeneCD276chr15:73996814chr15:73994589ENST00000318443+610243_357456535.0DomainNote=Ig-like V-type 2
HgeneCD276chr15:73996814chr15:73994589ENST00000318443+61029_139456535.0DomainNote=Ig-like V-type 1
HgeneCD276chr15:73996814chr15:73994589ENST00000318443+610363_456456535.0DomainNote=Ig-like C2-type 2
HgeneCD276chr15:73996814chr15:73994589ENST00000537340+59145_238310389.0DomainNote=Ig-like C2-type 1
HgeneCD276chr15:73996814chr15:73994589ENST00000537340+5929_139310389.0DomainNote=Ig-like V-type 1
HgeneCD276chr15:73996814chr15:73994589ENST00000561213+69145_238456534.0DomainNote=Ig-like C2-type 1
HgeneCD276chr15:73996814chr15:73994589ENST00000561213+69243_357456534.0DomainNote=Ig-like V-type 2
HgeneCD276chr15:73996814chr15:73994589ENST00000561213+6929_139456534.0DomainNote=Ig-like V-type 1
HgeneCD276chr15:73996814chr15:73994589ENST00000561213+69363_456456534.0DomainNote=Ig-like C2-type 2
HgeneCD276chr15:73996814chr15:73994589ENST00000564751+37145_238238317.0DomainNote=Ig-like C2-type 1
HgeneCD276chr15:73996814chr15:73994589ENST00000564751+3729_139238317.0DomainNote=Ig-like V-type 1
TgeneCD276chr15:73996814chr15:73994589ENST0000031842418145_23826317.0DomainNote=Ig-like C2-type 1
TgeneCD276chr15:73996814chr15:73994589ENST0000031842418243_35726317.0DomainNote=Ig-like V-type 2
TgeneCD276chr15:73996814chr15:73994589ENST000003184241829_13926317.0DomainNote=Ig-like V-type 1
TgeneCD276chr15:73996814chr15:73994589ENST0000031842418363_45626317.0DomainNote=Ig-like C2-type 2
TgeneCD276chr15:73996814chr15:73994589ENST00000318443110145_23826535.0DomainNote=Ig-like C2-type 1
TgeneCD276chr15:73996814chr15:73994589ENST00000318443110243_35726535.0DomainNote=Ig-like V-type 2
TgeneCD276chr15:73996814chr15:73994589ENST0000031844311029_13926535.0DomainNote=Ig-like V-type 1
TgeneCD276chr15:73996814chr15:73994589ENST00000318443110363_45626535.0DomainNote=Ig-like C2-type 2
TgeneCD276chr15:73996814chr15:73994589ENST0000053734009145_2380389.0DomainNote=Ig-like C2-type 1
TgeneCD276chr15:73996814chr15:73994589ENST0000053734009243_3570389.0DomainNote=Ig-like V-type 2
TgeneCD276chr15:73996814chr15:73994589ENST000005373400929_1390389.0DomainNote=Ig-like V-type 1
TgeneCD276chr15:73996814chr15:73994589ENST0000053734009363_4560389.0DomainNote=Ig-like C2-type 2
TgeneCD276chr15:73996814chr15:73994589ENST0000056121319145_23826534.0DomainNote=Ig-like C2-type 1
TgeneCD276chr15:73996814chr15:73994589ENST0000056121319243_35726534.0DomainNote=Ig-like V-type 2
TgeneCD276chr15:73996814chr15:73994589ENST000005612131929_13926534.0DomainNote=Ig-like V-type 1
TgeneCD276chr15:73996814chr15:73994589ENST0000056121319363_45626534.0DomainNote=Ig-like C2-type 2
TgeneCD276chr15:73996814chr15:73994589ENST0000056475107145_23826317.0DomainNote=Ig-like C2-type 1
TgeneCD276chr15:73996814chr15:73994589ENST0000056475107243_35726317.0DomainNote=Ig-like V-type 2
TgeneCD276chr15:73996814chr15:73994589ENST000005647510729_13926317.0DomainNote=Ig-like V-type 1
TgeneCD276chr15:73996814chr15:73994589ENST0000056475107363_45626317.0DomainNote=Ig-like C2-type 2
TgeneCD276chr15:73996814chr15:73994589ENST000003184241829_46626317.0Topological domainExtracellular
TgeneCD276chr15:73996814chr15:73994589ENST0000031842418488_53426317.0Topological domainCytoplasmic
TgeneCD276chr15:73996814chr15:73994589ENST0000031844311029_46626535.0Topological domainExtracellular
TgeneCD276chr15:73996814chr15:73994589ENST00000318443110488_53426535.0Topological domainCytoplasmic
TgeneCD276chr15:73996814chr15:73994589ENST000005373400929_4660389.0Topological domainExtracellular
TgeneCD276chr15:73996814chr15:73994589ENST0000053734009488_5340389.0Topological domainCytoplasmic
TgeneCD276chr15:73996814chr15:73994589ENST000005612131929_46626534.0Topological domainExtracellular
TgeneCD276chr15:73996814chr15:73994589ENST0000056121319488_53426534.0Topological domainCytoplasmic
TgeneCD276chr15:73996814chr15:73994589ENST000005647510729_46626317.0Topological domainExtracellular
TgeneCD276chr15:73996814chr15:73994589ENST0000056475107488_53426317.0Topological domainCytoplasmic
TgeneCD276chr15:73996814chr15:73994589ENST0000031842418467_48726317.0TransmembraneHelical
TgeneCD276chr15:73996814chr15:73994589ENST00000318443110467_48726535.0TransmembraneHelical
TgeneCD276chr15:73996814chr15:73994589ENST0000053734009467_4870389.0TransmembraneHelical
TgeneCD276chr15:73996814chr15:73994589ENST0000056121319467_48726534.0TransmembraneHelical
TgeneCD276chr15:73996814chr15:73994589ENST0000056475107467_48726317.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD276chr15:73996814chr15:73994589ENST00000318424+48243_357238317.0DomainNote=Ig-like V-type 2
HgeneCD276chr15:73996814chr15:73994589ENST00000318424+48363_456238317.0DomainNote=Ig-like C2-type 2
HgeneCD276chr15:73996814chr15:73994589ENST00000537340+59243_357310389.0DomainNote=Ig-like V-type 2
HgeneCD276chr15:73996814chr15:73994589ENST00000537340+59363_456310389.0DomainNote=Ig-like C2-type 2
HgeneCD276chr15:73996814chr15:73994589ENST00000564751+37243_357238317.0DomainNote=Ig-like V-type 2
HgeneCD276chr15:73996814chr15:73994589ENST00000564751+37363_456238317.0DomainNote=Ig-like C2-type 2
HgeneCD276chr15:73996814chr15:73994589ENST00000318424+4829_466238317.0Topological domainExtracellular
HgeneCD276chr15:73996814chr15:73994589ENST00000318424+48488_534238317.0Topological domainCytoplasmic
HgeneCD276chr15:73996814chr15:73994589ENST00000318443+61029_466456535.0Topological domainExtracellular
HgeneCD276chr15:73996814chr15:73994589ENST00000318443+610488_534456535.0Topological domainCytoplasmic
HgeneCD276chr15:73996814chr15:73994589ENST00000537340+5929_466310389.0Topological domainExtracellular
HgeneCD276chr15:73996814chr15:73994589ENST00000537340+59488_534310389.0Topological domainCytoplasmic
HgeneCD276chr15:73996814chr15:73994589ENST00000561213+6929_466456534.0Topological domainExtracellular
HgeneCD276chr15:73996814chr15:73994589ENST00000561213+69488_534456534.0Topological domainCytoplasmic
HgeneCD276chr15:73996814chr15:73994589ENST00000564751+3729_466238317.0Topological domainExtracellular
HgeneCD276chr15:73996814chr15:73994589ENST00000564751+37488_534238317.0Topological domainCytoplasmic
HgeneCD276chr15:73996814chr15:73994589ENST00000318424+48467_487238317.0TransmembraneHelical
HgeneCD276chr15:73996814chr15:73994589ENST00000318443+610467_487456535.0TransmembraneHelical
HgeneCD276chr15:73996814chr15:73994589ENST00000537340+59467_487310389.0TransmembraneHelical
HgeneCD276chr15:73996814chr15:73994589ENST00000561213+69467_487456534.0TransmembraneHelical
HgeneCD276chr15:73996814chr15:73994589ENST00000564751+37467_487238317.0TransmembraneHelical


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Fusion Gene Sequence for CD276-CD276


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CD276-CD276


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD276-CD276


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD276-CD276


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource