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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ACPP-AXL (FusionGDB2 ID:1445)

Fusion Gene Summary for ACPP-AXL

Fusion gene summary

Fusion gene information	Fusion gene name: ACPP-AXL
	Fusion gene ID: 1445
		Hgene	Tgene
	Gene symbol	ACPP	AXL
	Gene ID	55	558
	Gene name	acid phosphatase 3	AXL receptor tyrosine kinase
	Synonyms	5'-NT\|ACP-3\|ACPP\|TM-PAP	ARK\|JTK11\|Tyro7\|UFO
	Cytomap	3q22.1	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	prostatic acid phosphataseTMPaseacid phosphatase, prostateecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatase	tyrosine-protein kinase receptor UFOAXL oncogeneAXL transforming sequence/gene
	Modification date	20200313	20200327
	UniProtAcc	.	P30530
	Ensembl transtripts involved in fusion gene	ENST00000336375, ENST00000351273, ENST00000475741, ENST00000489084,	ENST00000593513, ENST00000594880, ENST00000301178, ENST00000359092,
Fusion gene scores	* DoF score	28 X 17 X 4=1904	3 X 3 X 3=27
	# samples	31	4
	** MAII score	log2(31/1904*10)=-2.61869335803371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ACPP [Title/Abstract] AND AXL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACPP(132075699)-AXL(41748788), # samples:2 ACPP(132075699)-AXL(41748787), # samples:2
Anticipated loss of major functional domain due to fusion event.	ACPP-AXL seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ACPP-AXL seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ACPP-AXL seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ACPP	GO:0046085	adenosine metabolic process	18940592
Tgene	AXL	GO:0001961	positive regulation of cytokine-mediated signaling pathway	18840707
Tgene	AXL	GO:0006909	phagocytosis	21501828
Tgene	AXL	GO:0032689	negative regulation of interferon-gamma production	18840707
Tgene	AXL	GO:0032825	positive regulation of natural killer cell differentiation	18840707
Tgene	AXL	GO:0035457	cellular response to interferon-alpha	19657094
Tgene	AXL	GO:0071222	cellular response to lipopolysaccharide	19657094
Tgene	AXL	GO:2000669	negative regulation of dendritic cell apoptotic process	19657094

Fusion gene breakpoints across ACPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AXL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-J4-A6G3-01A	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
ChimerDB4	PRAD	TCGA-J4-A6G3	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
ChimerDB4	PRAD	TCGA-J4-A6G3	ACPP	chr3	132075699	+	AXL	chr19	41748788	+

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Fusion Gene ORF analysis for ACPP-AXL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000336375	ENST00000593513	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
5CDS-intron	ENST00000336375	ENST00000593513	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
5CDS-intron	ENST00000336375	ENST00000594880	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
5CDS-intron	ENST00000336375	ENST00000594880	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
5CDS-intron	ENST00000351273	ENST00000593513	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
5CDS-intron	ENST00000351273	ENST00000593513	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
5CDS-intron	ENST00000351273	ENST00000594880	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
5CDS-intron	ENST00000351273	ENST00000594880	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
5CDS-intron	ENST00000475741	ENST00000593513	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
5CDS-intron	ENST00000475741	ENST00000593513	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
5CDS-intron	ENST00000475741	ENST00000594880	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
5CDS-intron	ENST00000475741	ENST00000594880	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
Frame-shift	ENST00000336375	ENST00000301178	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
Frame-shift	ENST00000336375	ENST00000301178	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
Frame-shift	ENST00000336375	ENST00000359092	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
Frame-shift	ENST00000336375	ENST00000359092	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
Frame-shift	ENST00000475741	ENST00000301178	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
Frame-shift	ENST00000475741	ENST00000301178	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
Frame-shift	ENST00000475741	ENST00000359092	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
Frame-shift	ENST00000475741	ENST00000359092	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
In-frame	ENST00000351273	ENST00000301178	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
In-frame	ENST00000351273	ENST00000301178	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
In-frame	ENST00000351273	ENST00000359092	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
In-frame	ENST00000351273	ENST00000359092	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
intron-3CDS	ENST00000489084	ENST00000301178	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
intron-3CDS	ENST00000489084	ENST00000301178	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
intron-3CDS	ENST00000489084	ENST00000359092	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
intron-3CDS	ENST00000489084	ENST00000359092	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
intron-intron	ENST00000489084	ENST00000593513	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
intron-intron	ENST00000489084	ENST00000593513	ACPP	chr3	132075699	+	AXL	chr19	41748787	+
intron-intron	ENST00000489084	ENST00000594880	ACPP	chr3	132075699	+	AXL	chr19	41748788	+
intron-intron	ENST00000489084	ENST00000594880	ACPP	chr3	132075699	+	AXL	chr19	41748787	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000351273

ACPP

chr3

132075699

ENST00000301178

AXL

chr19

41748788

4423

1188

2560

844

ENST00000351273

ACPP

chr3

132075699

ENST00000359092

AXL

chr19

41748788

2951

1188

2560

844

ENST00000351273

ACPP

chr3

132075699

ENST00000301178

AXL

chr19

41748787

4423

1188

2560

844

ENST00000351273

ACPP

chr3

132075699

ENST00000359092

AXL

chr19

41748787

2951

1188

2560

844

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000351273	ENST00000301178	ACPP	chr3	132075699	+	AXL	chr19	41748788	+	0.000322418	0.99967754
ENST00000351273	ENST00000359092	ACPP	chr3	132075699	+	AXL	chr19	41748788	+	0.001340488	0.9986595
ENST00000351273	ENST00000301178	ACPP	chr3	132075699	+	AXL	chr19	41748787	+	0.000322418	0.99967754
ENST00000351273	ENST00000359092	ACPP	chr3	132075699	+	AXL	chr19	41748787	+	0.001340488	0.9986595

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Fusion Genomic Features for ACPP-AXL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ACPP	chr3	132075699	+	AXL	chr19	41748787	+	7.82E-06	0.99999213
ACPP	chr3	132075699	+	AXL	chr19	41748787	+	7.82E-06	0.99999213
ACPP	chr3	132075699	+	AXL	chr19	41748787	+	7.82E-06	0.99999213
ACPP	chr3	132075699	+	AXL	chr19	41748787	+	7.82E-06	0.99999213

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACPP-AXL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:132075699/chr19:41748788)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	AXL P30530
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269\|PubMed:10403904, ECO:0000269\|PubMed:11484958, ECO:0000269\|PubMed:12364394, ECO:0000269\|PubMed:12490074, ECO:0000269\|PubMed:15507525, ECO:0000269\|PubMed:15733062, ECO:0000269\|PubMed:1656220, ECO:0000269\|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269\|PubMed:17005688, ECO:0000269\|PubMed:21501828, ECO:0000269\|PubMed:22156524, ECO:0000269\|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269\|PubMed:22673088}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000301178

536_807

437

895.0

Domain

Protein kinase

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000359092

536_807

428

886.0

Domain

Protein kinase

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000301178

536_807

437

895.0

Domain

Protein kinase

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000359092

536_807

428

886.0

Domain

Protein kinase

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000301178

542_550

437

895.0

Nucleotide binding

ATP

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000359092

542_550

428

886.0

Nucleotide binding

ATP

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000301178

542_550

437

895.0

Nucleotide binding

ATP

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000359092

542_550

428

886.0

Nucleotide binding

ATP

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000301178

473_894

437

895.0

Topological domain

Cytoplasmic

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000359092

473_894

428

886.0

Topological domain

Cytoplasmic

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000301178

473_894

437

895.0

Topological domain

Cytoplasmic

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000359092

473_894

428

886.0

Topological domain

Cytoplasmic

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000301178

452_472

437

895.0

Transmembrane

Helical

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000359092

452_472

428

886.0

Transmembrane

Helical

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000301178

452_472

437

895.0

Transmembrane

Helical

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000359092

452_472

428

886.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000301178

139_222

437

895.0

Domain

Note=Ig-like C2-type 2

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000301178

227_331

437

895.0

Domain

Fibronectin type-III 1

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000301178

27_128

437

895.0

Domain

Note=Ig-like C2-type 1

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000301178

336_428

437

895.0

Domain

Fibronectin type-III 2

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000359092

139_222

428

886.0

Domain

Note=Ig-like C2-type 2

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000359092

227_331

428

886.0

Domain

Fibronectin type-III 1

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000359092

27_128

428

886.0

Domain

Note=Ig-like C2-type 1

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000359092

336_428

428

886.0

Domain

Fibronectin type-III 2

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000301178

139_222

437

895.0

Domain

Note=Ig-like C2-type 2

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000301178

227_331

437

895.0

Domain

Fibronectin type-III 1

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000301178

27_128

437

895.0

Domain

Note=Ig-like C2-type 1

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000301178

336_428

437

895.0

Domain

Fibronectin type-III 2

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000359092

139_222

428

886.0

Domain

Note=Ig-like C2-type 2

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000359092

227_331

428

886.0

Domain

Fibronectin type-III 1

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000359092

27_128

428

886.0

Domain

Note=Ig-like C2-type 1

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000359092

336_428

428

886.0

Domain

Fibronectin type-III 2

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000301178

26_451

437

895.0

Topological domain

Extracellular

Tgene

AXL

chr3:132075699

chr19:41748787

ENST00000359092

26_451

428

886.0

Topological domain

Extracellular

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000301178

26_451

437

895.0

Topological domain

Extracellular

Tgene

AXL

chr3:132075699

chr19:41748788

ENST00000359092

26_451

428

886.0

Topological domain

Extracellular

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Fusion Gene Sequence for ACPP-AXL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>1445_1445_1_ACPP-AXL_ACPP_chr3_132075699_ENST00000351273_AXL_chr19_41748787_ENST00000301178_length(transcript)=4423nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGTGAAGGAACCTTCAACTCCTGCCTTCTCGTGGCCCTGGTGGTATGTACTGCTAGGAGCAGTCGTGGCCGCTG
CCTGTGTCCTCATCTTGGCTCTCTTCCTTGTCCACCGGCGAAAGAAGGAGACCCGTTATGGAGAAGTGTTTGAACCAACAGTGGAAAGAG
GTGAACTGGTAGTCAGGTACCGCGTGCGCAAGTCCTACAGTCGTCGGACCACTGAAGCTACCTTGAACAGCCTGGGCATCAGTGAAGAGC
TGAAGGAGAAGCTGCGGGATGTGATGGTGGACCGGCACAAGGTGGCCCTGGGGAAGACTCTGGGAGAGGGAGAGTTTGGAGCTGTGATGG
AAGGCCAGCTCAACCAGGACGACTCCATCCTCAAGGTGGCTGTGAAGACGATGAAGATTGCCATCTGCACGAGGTCAGAGCTGGAGGATT
TCCTGAGTGAAGCGGTCTGCATGAAGGAATTTGACCATCCCAACGTCATGAGGCTCATCGGTGTCTGTTTCCAGGGTTCTGAACGAGAGA
GCTTCCCAGCACCTGTGGTCATCTTACCTTTCATGAAACATGGAGACCTACACAGCTTCCTCCTCTATTCCCGGCTCGGGGACCAGCCAG
TGTACCTGCCCACTCAGATGCTAGTGAAGTTCATGGCAGACATCGCCAGTGGCATGGAGTATCTGAGTACCAAGAGATTCATACACCGGG
ACCTGGCGGCCAGGAACTGCATGCTGAATGAGAACATGTCCGTGTGTGTGGCGGACTTCGGGCTCTCCAAGAAGATCTACAATGGGGACT
ACTACCGCCAGGGACGTATCGCCAAGATGCCAGTCAAGTGGATTGCCATTGAGAGTCTAGCTGACCGTGTCTACACCAGCAAGAGCGATG
TGTGGTCCTTCGGGGTGACAATGTGGGAGATTGCCACAAGAGGCCAAACCCCATATCCGGGCGTGGAGAACAGCGAGATTTATGACTATC
TGCGCCAGGGAAATCGCCTGAAGCAGCCTGCGGACTGTCTGGATGGACTGTATGCCTTGATGTCGCGGTGCTGGGAGCTAAATCCCCAGG
ACCGGCCAAGTTTTACAGAGCTGCGGGAAGATTTGGAGAACACACTGAAGGCCTTGCCTCCTGCCCAGGAGCCTGACGAAATCCTCTATG
TCAACATGGATGAGGGTGGAGGTTATCCTGAACCCCCTGGAGCTGCAGGAGGAGCTGACCCCCCAACCCAGCCAGACCCTAAGGATTCCT
GTAGCTGCCTCACTGCGGCTGAGGTCCATCCTGCTGGACGCTATGTCCTCTGCCCTTCCACAACCCCTAGCCCCGCTCAGCCTGCTGATA
GGGGCTCCCCAGCAGCCCCAGGGCAGGAGGATGGTGCCTGAGACAACCCTCCACCTGGTACTCCCTCTCAGGATCCAAGCTAAGCACTGC
CACTGGGGAAAACTCCACCTTCCCACTTTCCCACCCCACGCCTTATCCCCACTTGCAGCCCTGTCTTCCTACCTATCCCACCTCCATCCC
AGACAGGTCCCTCCCCTTCTCTGTGCAGTAGCATCACCTTGAAAGCAGTAGCATCACCATCTGTAAAAGGAAGGGGTTGGATTGCAATAT
CTGAAGCCCTCCCAGGTGTTAACATTCCAAGACTCTAGAGTCCAAGGTTTAAAGAGTCTAGATTCAAAGGTTCTAGGTTTCAAAGATGCT
GTGAGTCTTTGGTTCTAAGGACCTGAAATTCCAAAGTCTCTAATTCTATTAAAGTGCTAAGGTTCTAAGGCCTACTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTGCGATAGAGTCTCACTGTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCGCCTCACTGCAACCTTCACCTAC
CGAGTTCAAGTGATTTTCCTGCCTTGGCCTCCCAAGTAGCTGGGATTACAGGTGTGTGCCACCACACCCGGCTAATTTTTATATTTTTAG
TAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTAAAACTCCTGACCTCAAGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGA
TTACAGGCATGAGCCACTGCACTCAACCTTAAGACCTACTGTTCTAAAGCTCTGACATTATGTGGTTTTAGATTTTCTGGTTCTAACATT
TTTGATAAAGCCTCAAGGTTTTAGGTTCTAAAGTTCTAAGATTCTGATTTTAGGAGCTAAGGCTCTATGAGTCTAGATGTTTATTCTTCT
AGAGTTCAGAGTCCTTAAAATGTAAGATTATAGATTCTAAAGATTCTATAGTTCTAGACATGGAGGTTCTAAGGCCTAGGATTCTAAAAT
GTGATGTTCTAAGGCTCTGAGAGTCTAGATTCTCTGGCTGTAAGGCTCTAGATCATAAGGCTTCAAAATGTTATCTTCTCAAGTTCTAAG
ATTCTAATGATGATCAATTATAGTTTCTGAGGCTTTATGATAATAGATTCTCTTGTATAAGATCCTAGATCCTAAGGGTCGAAAGCTCTA
GAATCTGCAATTCAAAAGTTCCAAGAGTCTAAAGATGGAGTTTCTAAGGTCCGGTGTTCTAAGATGTGATATTCTAAGACTTACTCTAAG
ATCTTAGATTCTCTGTGTCTAAGATTCTAGATCAGATGCTCCAAGATTCTAGATGATTAAATAAGATTCTAACGGTCTGTTCTGTTTCAA
GGCACTCTAGATTCCATTGGTCCAAGATTCCGGATCCTAAGCATCTAAGTTATAAGACTCTCACACTCAGTTGTGACTAACTAGACACCA
AAGTTCTAATAATTTCTAATGTTGGACACCTTTAGGTTCTTTGCTGCATTCTGCCTCTCTAGGACCATGGTTAAGAGTCCAAGAATCCAC
ATTTCTAAAATCTTATAGTTCTAGGCACTGTAGTTCTAAGACTCAAATGTTCTAAGTTTCTAAGATTCTAAAGGTCCACAGGTCTAGACT
ATTAGGTGCAATTTCAAGGTTCTAACCCTATACTGTAGTATTCTTTGGGGTGCCCCTCTCCTTCTTAGCTATCATTGCTTCCTCCTCCCC
AACTGTGGGGGTGTGCCCCCTTCAAGCCTGTGCAATGCATTAGGGATGCCTCCTTTCCCGCAGGGGATGGACGATCTCCCACCTTTCGGG
CCATGTTGCCCCCGTGAGCCAATCCCTCACCTTCTGAGTACAGAGTGTGGACTCTGGTGCCTCCAGAGGGGCTCAGGTCACATAAAACTT

>1445_1445_1_ACPP-AXL_ACPP_chr3_132075699_ENST00000351273_AXL_chr19_41748787_ENST00000301178_length(amino acids)=844AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRV
RKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK
EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCML
NENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ
PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEV

--------------------------------------------------------------
>1445_1445_2_ACPP-AXL_ACPP_chr3_132075699_ENST00000351273_AXL_chr19_41748787_ENST00000359092_length(transcript)=2951nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGTGAAGGAACCTTCAACTCCTGCCTTCTCGTGGCCCTGGTGGTATGTACTGCTAGGAGCAGTCGTGGCCGCTG
CCTGTGTCCTCATCTTGGCTCTCTTCCTTGTCCACCGGCGAAAGAAGGAGACCCGTTATGGAGAAGTGTTTGAACCAACAGTGGAAAGAG
GTGAACTGGTAGTCAGGTACCGCGTGCGCAAGTCCTACAGTCGTCGGACCACTGAAGCTACCTTGAACAGCCTGGGCATCAGTGAAGAGC
TGAAGGAGAAGCTGCGGGATGTGATGGTGGACCGGCACAAGGTGGCCCTGGGGAAGACTCTGGGAGAGGGAGAGTTTGGAGCTGTGATGG
AAGGCCAGCTCAACCAGGACGACTCCATCCTCAAGGTGGCTGTGAAGACGATGAAGATTGCCATCTGCACGAGGTCAGAGCTGGAGGATT
TCCTGAGTGAAGCGGTCTGCATGAAGGAATTTGACCATCCCAACGTCATGAGGCTCATCGGTGTCTGTTTCCAGGGTTCTGAACGAGAGA
GCTTCCCAGCACCTGTGGTCATCTTACCTTTCATGAAACATGGAGACCTACACAGCTTCCTCCTCTATTCCCGGCTCGGGGACCAGCCAG
TGTACCTGCCCACTCAGATGCTAGTGAAGTTCATGGCAGACATCGCCAGTGGCATGGAGTATCTGAGTACCAAGAGATTCATACACCGGG
ACCTGGCGGCCAGGAACTGCATGCTGAATGAGAACATGTCCGTGTGTGTGGCGGACTTCGGGCTCTCCAAGAAGATCTACAATGGGGACT
ACTACCGCCAGGGACGTATCGCCAAGATGCCAGTCAAGTGGATTGCCATTGAGAGTCTAGCTGACCGTGTCTACACCAGCAAGAGCGATG
TGTGGTCCTTCGGGGTGACAATGTGGGAGATTGCCACAAGAGGCCAAACCCCATATCCGGGCGTGGAGAACAGCGAGATTTATGACTATC
TGCGCCAGGGAAATCGCCTGAAGCAGCCTGCGGACTGTCTGGATGGACTGTATGCCTTGATGTCGCGGTGCTGGGAGCTAAATCCCCAGG
ACCGGCCAAGTTTTACAGAGCTGCGGGAAGATTTGGAGAACACACTGAAGGCCTTGCCTCCTGCCCAGGAGCCTGACGAAATCCTCTATG
TCAACATGGATGAGGGTGGAGGTTATCCTGAACCCCCTGGAGCTGCAGGAGGAGCTGACCCCCCAACCCAGCCAGACCCTAAGGATTCCT
GTAGCTGCCTCACTGCGGCTGAGGTCCATCCTGCTGGACGCTATGTCCTCTGCCCTTCCACAACCCCTAGCCCCGCTCAGCCTGCTGATA
GGGGCTCCCCAGCAGCCCCAGGGCAGGAGGATGGTGCCTGAGACAACCCTCCACCTGGTACTCCCTCTCAGGATCCAAGCTAAGCACTGC
CACTGGGGAAAACTCCACCTTCCCACTTTCCCACCCCACGCCTTATCCCCACTTGCAGCCCTGTCTTCCTACCTATCCCACCTCCATCCC
AGACAGGTCCCTCCCCTTCTCTGTGCAGTAGCATCACCTTGAAAGCAGTAGCATCACCATCTGTAAAAGGAAGGGGTTGGATTGCAATAT
CTGAAGCCCTCCCAGGTGTTAACATTCCAAGACTCTAGAGTCCAAGGTTTAAAGAGTCTAGATTCAAAGGTTCTAGGTTTCAAAGATGCT

>1445_1445_2_ACPP-AXL_ACPP_chr3_132075699_ENST00000351273_AXL_chr19_41748787_ENST00000359092_length(amino acids)=844AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRV
RKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK
EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCML
NENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ
PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEV

--------------------------------------------------------------
>1445_1445_3_ACPP-AXL_ACPP_chr3_132075699_ENST00000351273_AXL_chr19_41748788_ENST00000301178_length(transcript)=4423nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGTGAAGGAACCTTCAACTCCTGCCTTCTCGTGGCCCTGGTGGTATGTACTGCTAGGAGCAGTCGTGGCCGCTG
CCTGTGTCCTCATCTTGGCTCTCTTCCTTGTCCACCGGCGAAAGAAGGAGACCCGTTATGGAGAAGTGTTTGAACCAACAGTGGAAAGAG
GTGAACTGGTAGTCAGGTACCGCGTGCGCAAGTCCTACAGTCGTCGGACCACTGAAGCTACCTTGAACAGCCTGGGCATCAGTGAAGAGC
TGAAGGAGAAGCTGCGGGATGTGATGGTGGACCGGCACAAGGTGGCCCTGGGGAAGACTCTGGGAGAGGGAGAGTTTGGAGCTGTGATGG
AAGGCCAGCTCAACCAGGACGACTCCATCCTCAAGGTGGCTGTGAAGACGATGAAGATTGCCATCTGCACGAGGTCAGAGCTGGAGGATT
TCCTGAGTGAAGCGGTCTGCATGAAGGAATTTGACCATCCCAACGTCATGAGGCTCATCGGTGTCTGTTTCCAGGGTTCTGAACGAGAGA
GCTTCCCAGCACCTGTGGTCATCTTACCTTTCATGAAACATGGAGACCTACACAGCTTCCTCCTCTATTCCCGGCTCGGGGACCAGCCAG
TGTACCTGCCCACTCAGATGCTAGTGAAGTTCATGGCAGACATCGCCAGTGGCATGGAGTATCTGAGTACCAAGAGATTCATACACCGGG
ACCTGGCGGCCAGGAACTGCATGCTGAATGAGAACATGTCCGTGTGTGTGGCGGACTTCGGGCTCTCCAAGAAGATCTACAATGGGGACT
ACTACCGCCAGGGACGTATCGCCAAGATGCCAGTCAAGTGGATTGCCATTGAGAGTCTAGCTGACCGTGTCTACACCAGCAAGAGCGATG
TGTGGTCCTTCGGGGTGACAATGTGGGAGATTGCCACAAGAGGCCAAACCCCATATCCGGGCGTGGAGAACAGCGAGATTTATGACTATC
TGCGCCAGGGAAATCGCCTGAAGCAGCCTGCGGACTGTCTGGATGGACTGTATGCCTTGATGTCGCGGTGCTGGGAGCTAAATCCCCAGG
ACCGGCCAAGTTTTACAGAGCTGCGGGAAGATTTGGAGAACACACTGAAGGCCTTGCCTCCTGCCCAGGAGCCTGACGAAATCCTCTATG
TCAACATGGATGAGGGTGGAGGTTATCCTGAACCCCCTGGAGCTGCAGGAGGAGCTGACCCCCCAACCCAGCCAGACCCTAAGGATTCCT
GTAGCTGCCTCACTGCGGCTGAGGTCCATCCTGCTGGACGCTATGTCCTCTGCCCTTCCACAACCCCTAGCCCCGCTCAGCCTGCTGATA
GGGGCTCCCCAGCAGCCCCAGGGCAGGAGGATGGTGCCTGAGACAACCCTCCACCTGGTACTCCCTCTCAGGATCCAAGCTAAGCACTGC
CACTGGGGAAAACTCCACCTTCCCACTTTCCCACCCCACGCCTTATCCCCACTTGCAGCCCTGTCTTCCTACCTATCCCACCTCCATCCC
AGACAGGTCCCTCCCCTTCTCTGTGCAGTAGCATCACCTTGAAAGCAGTAGCATCACCATCTGTAAAAGGAAGGGGTTGGATTGCAATAT
CTGAAGCCCTCCCAGGTGTTAACATTCCAAGACTCTAGAGTCCAAGGTTTAAAGAGTCTAGATTCAAAGGTTCTAGGTTTCAAAGATGCT
GTGAGTCTTTGGTTCTAAGGACCTGAAATTCCAAAGTCTCTAATTCTATTAAAGTGCTAAGGTTCTAAGGCCTACTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTGCGATAGAGTCTCACTGTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCGCCTCACTGCAACCTTCACCTAC
CGAGTTCAAGTGATTTTCCTGCCTTGGCCTCCCAAGTAGCTGGGATTACAGGTGTGTGCCACCACACCCGGCTAATTTTTATATTTTTAG
TAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTAAAACTCCTGACCTCAAGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGA
TTACAGGCATGAGCCACTGCACTCAACCTTAAGACCTACTGTTCTAAAGCTCTGACATTATGTGGTTTTAGATTTTCTGGTTCTAACATT
TTTGATAAAGCCTCAAGGTTTTAGGTTCTAAAGTTCTAAGATTCTGATTTTAGGAGCTAAGGCTCTATGAGTCTAGATGTTTATTCTTCT
AGAGTTCAGAGTCCTTAAAATGTAAGATTATAGATTCTAAAGATTCTATAGTTCTAGACATGGAGGTTCTAAGGCCTAGGATTCTAAAAT
GTGATGTTCTAAGGCTCTGAGAGTCTAGATTCTCTGGCTGTAAGGCTCTAGATCATAAGGCTTCAAAATGTTATCTTCTCAAGTTCTAAG
ATTCTAATGATGATCAATTATAGTTTCTGAGGCTTTATGATAATAGATTCTCTTGTATAAGATCCTAGATCCTAAGGGTCGAAAGCTCTA
GAATCTGCAATTCAAAAGTTCCAAGAGTCTAAAGATGGAGTTTCTAAGGTCCGGTGTTCTAAGATGTGATATTCTAAGACTTACTCTAAG
ATCTTAGATTCTCTGTGTCTAAGATTCTAGATCAGATGCTCCAAGATTCTAGATGATTAAATAAGATTCTAACGGTCTGTTCTGTTTCAA
GGCACTCTAGATTCCATTGGTCCAAGATTCCGGATCCTAAGCATCTAAGTTATAAGACTCTCACACTCAGTTGTGACTAACTAGACACCA
AAGTTCTAATAATTTCTAATGTTGGACACCTTTAGGTTCTTTGCTGCATTCTGCCTCTCTAGGACCATGGTTAAGAGTCCAAGAATCCAC
ATTTCTAAAATCTTATAGTTCTAGGCACTGTAGTTCTAAGACTCAAATGTTCTAAGTTTCTAAGATTCTAAAGGTCCACAGGTCTAGACT
ATTAGGTGCAATTTCAAGGTTCTAACCCTATACTGTAGTATTCTTTGGGGTGCCCCTCTCCTTCTTAGCTATCATTGCTTCCTCCTCCCC
AACTGTGGGGGTGTGCCCCCTTCAAGCCTGTGCAATGCATTAGGGATGCCTCCTTTCCCGCAGGGGATGGACGATCTCCCACCTTTCGGG
CCATGTTGCCCCCGTGAGCCAATCCCTCACCTTCTGAGTACAGAGTGTGGACTCTGGTGCCTCCAGAGGGGCTCAGGTCACATAAAACTT

>1445_1445_3_ACPP-AXL_ACPP_chr3_132075699_ENST00000351273_AXL_chr19_41748788_ENST00000301178_length(amino acids)=844AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRV
RKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK
EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCML
NENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ
PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEV

--------------------------------------------------------------
>1445_1445_4_ACPP-AXL_ACPP_chr3_132075699_ENST00000351273_AXL_chr19_41748788_ENST00000359092_length(transcript)=2951nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGTGAAGGAACCTTCAACTCCTGCCTTCTCGTGGCCCTGGTGGTATGTACTGCTAGGAGCAGTCGTGGCCGCTG
CCTGTGTCCTCATCTTGGCTCTCTTCCTTGTCCACCGGCGAAAGAAGGAGACCCGTTATGGAGAAGTGTTTGAACCAACAGTGGAAAGAG
GTGAACTGGTAGTCAGGTACCGCGTGCGCAAGTCCTACAGTCGTCGGACCACTGAAGCTACCTTGAACAGCCTGGGCATCAGTGAAGAGC
TGAAGGAGAAGCTGCGGGATGTGATGGTGGACCGGCACAAGGTGGCCCTGGGGAAGACTCTGGGAGAGGGAGAGTTTGGAGCTGTGATGG
AAGGCCAGCTCAACCAGGACGACTCCATCCTCAAGGTGGCTGTGAAGACGATGAAGATTGCCATCTGCACGAGGTCAGAGCTGGAGGATT
TCCTGAGTGAAGCGGTCTGCATGAAGGAATTTGACCATCCCAACGTCATGAGGCTCATCGGTGTCTGTTTCCAGGGTTCTGAACGAGAGA
GCTTCCCAGCACCTGTGGTCATCTTACCTTTCATGAAACATGGAGACCTACACAGCTTCCTCCTCTATTCCCGGCTCGGGGACCAGCCAG
TGTACCTGCCCACTCAGATGCTAGTGAAGTTCATGGCAGACATCGCCAGTGGCATGGAGTATCTGAGTACCAAGAGATTCATACACCGGG
ACCTGGCGGCCAGGAACTGCATGCTGAATGAGAACATGTCCGTGTGTGTGGCGGACTTCGGGCTCTCCAAGAAGATCTACAATGGGGACT
ACTACCGCCAGGGACGTATCGCCAAGATGCCAGTCAAGTGGATTGCCATTGAGAGTCTAGCTGACCGTGTCTACACCAGCAAGAGCGATG
TGTGGTCCTTCGGGGTGACAATGTGGGAGATTGCCACAAGAGGCCAAACCCCATATCCGGGCGTGGAGAACAGCGAGATTTATGACTATC
TGCGCCAGGGAAATCGCCTGAAGCAGCCTGCGGACTGTCTGGATGGACTGTATGCCTTGATGTCGCGGTGCTGGGAGCTAAATCCCCAGG
ACCGGCCAAGTTTTACAGAGCTGCGGGAAGATTTGGAGAACACACTGAAGGCCTTGCCTCCTGCCCAGGAGCCTGACGAAATCCTCTATG
TCAACATGGATGAGGGTGGAGGTTATCCTGAACCCCCTGGAGCTGCAGGAGGAGCTGACCCCCCAACCCAGCCAGACCCTAAGGATTCCT
GTAGCTGCCTCACTGCGGCTGAGGTCCATCCTGCTGGACGCTATGTCCTCTGCCCTTCCACAACCCCTAGCCCCGCTCAGCCTGCTGATA
GGGGCTCCCCAGCAGCCCCAGGGCAGGAGGATGGTGCCTGAGACAACCCTCCACCTGGTACTCCCTCTCAGGATCCAAGCTAAGCACTGC
CACTGGGGAAAACTCCACCTTCCCACTTTCCCACCCCACGCCTTATCCCCACTTGCAGCCCTGTCTTCCTACCTATCCCACCTCCATCCC
AGACAGGTCCCTCCCCTTCTCTGTGCAGTAGCATCACCTTGAAAGCAGTAGCATCACCATCTGTAAAAGGAAGGGGTTGGATTGCAATAT
CTGAAGCCCTCCCAGGTGTTAACATTCCAAGACTCTAGAGTCCAAGGTTTAAAGAGTCTAGATTCAAAGGTTCTAGGTTTCAAAGATGCT

>1445_1445_4_ACPP-AXL_ACPP_chr3_132075699_ENST00000351273_AXL_chr19_41748788_ENST00000359092_length(amino acids)=844AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRV
RKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK
EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCML
NENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ
PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEV

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Fusion Gene PPI Analysis for ACPP-AXL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	AXL	chr3:132075699	chr19:41748787	ENST00000301178		9	20	26_92	437.3333333333333	895.0	GAS6
Tgene	AXL	chr3:132075699	chr19:41748787	ENST00000359092		8	19	26_92	428.3333333333333	886.0	GAS6
Tgene	AXL	chr3:132075699	chr19:41748788	ENST00000301178		9	20	26_92	437.3333333333333	895.0	GAS6
Tgene	AXL	chr3:132075699	chr19:41748788	ENST00000359092		8	19	26_92	428.3333333333333	886.0	GAS6

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ACPP-AXL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ACPP-AXL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source