Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CD36-ANGEL2 (FusionGDB2 ID:14483)

Fusion Gene Summary for CD36-ANGEL2

Fusion gene summary

Fusion gene information	Fusion gene name: CD36-ANGEL2
	Fusion gene ID: 14483
		Hgene	Tgene
	Gene symbol	CD36	ANGEL2
	Gene ID	948	90806
	Gene name	CD36 molecule	angel homolog 2
	Synonyms	BDPLT10\|CHDS7\|FAT\|GP3B\|GP4\|GPIV\|PASIV\|SCARB3	Ccr4d\|KIAA0759L
	Cytomap	7q21.11	1q32.3
	Type of gene	protein-coding	protein-coding
	Description	platelet glycoprotein 4CD36 antigen (collagen type I receptor, thrombospondin receptor)CD36 molecule (thrombospondin receptor)GPIIIBPAS IVPAS-4 proteincluster determinant 36fatty acid translocaseglycoprotein IIIbleukocyte differentiation antigen	protein angel homolog 2
	Modification date	20200322	20200313
	UniProtAcc	P16671	Q5VTE6
	Ensembl transtripts involved in fusion gene	ENST00000309881, ENST00000394788, ENST00000432207, ENST00000433696, ENST00000435819, ENST00000441109, ENST00000447544, ENST00000534394, ENST00000538969, ENST00000544133,	ENST00000360506, ENST00000366962, ENST00000473303, ENST00000535388, ENST00000540642, ENST00000544555,
Fusion gene scores	* DoF score	7 X 7 X 3=147	2 X 2 X 2=8
	# samples	7	2
	** MAII score	log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: CD36 [Title/Abstract] AND ANGEL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CD36(80047117)-ANGEL2(213168923), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CD36	GO:0001954	positive regulation of cell-matrix adhesion	17416590
Hgene	CD36	GO:0007263	nitric oxide mediated signal transduction	17416590
Hgene	CD36	GO:0019934	cGMP-mediated signaling	17416590
Hgene	CD36	GO:0044539	long-chain fatty acid import	17416590\|22022213
Hgene	CD36	GO:0071726	cellular response to diacyl bacterial lipopeptide	16880211

Fusion gene breakpoints across CD36 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANGEL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	EF580396	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
ChiTaRS5.0	N/A	EF580424	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+

Top

Fusion Gene ORF analysis for CD36-ANGEL2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000309881	ENST00000360506	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000309881	ENST00000366962	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000309881	ENST00000473303	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000309881	ENST00000535388	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000309881	ENST00000540642	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000309881	ENST00000544555	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000394788	ENST00000360506	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000394788	ENST00000366962	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000394788	ENST00000473303	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000394788	ENST00000535388	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000394788	ENST00000540642	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000394788	ENST00000544555	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000432207	ENST00000360506	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000432207	ENST00000366962	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000432207	ENST00000473303	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000432207	ENST00000535388	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000432207	ENST00000540642	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000432207	ENST00000544555	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000433696	ENST00000360506	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000433696	ENST00000366962	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000433696	ENST00000473303	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000433696	ENST00000535388	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000433696	ENST00000540642	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000433696	ENST00000544555	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000435819	ENST00000360506	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000435819	ENST00000366962	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000435819	ENST00000473303	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000435819	ENST00000535388	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000435819	ENST00000540642	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000435819	ENST00000544555	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000441109	ENST00000360506	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000441109	ENST00000366962	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000441109	ENST00000473303	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000441109	ENST00000535388	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000441109	ENST00000540642	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000441109	ENST00000544555	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000447544	ENST00000360506	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000447544	ENST00000366962	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000447544	ENST00000473303	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000447544	ENST00000535388	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000447544	ENST00000540642	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000447544	ENST00000544555	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000534394	ENST00000360506	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000534394	ENST00000366962	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000534394	ENST00000473303	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000534394	ENST00000535388	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000534394	ENST00000540642	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000534394	ENST00000544555	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000538969	ENST00000360506	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000538969	ENST00000366962	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000538969	ENST00000473303	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000538969	ENST00000535388	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000538969	ENST00000540642	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000538969	ENST00000544555	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000544133	ENST00000360506	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000544133	ENST00000366962	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000544133	ENST00000473303	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000544133	ENST00000535388	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000544133	ENST00000540642	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+
intron-intron	ENST00000544133	ENST00000544555	CD36	chr7	80047117	-	ANGEL2	chr1	213168923	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for CD36-ANGEL2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CD36-ANGEL2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:80047117/:213168923)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CD36 P16671	ANGEL2 Q5VTE6
FUNCTION: Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211). {ECO:0000250\|UniProtKB:Q07969, ECO:0000250\|UniProtKB:Q08857, ECO:0000269\|PubMed:16880211, ECO:0000269\|PubMed:18353783, ECO:0000269\|PubMed:18753675, ECO:0000269\|PubMed:20037584, ECO:0000269\|PubMed:21395585, ECO:0000269\|PubMed:21610069, ECO:0000269\|PubMed:22240721, ECO:0000269\|PubMed:25822988, ECO:0000305\|PubMed:19471024}.; FUNCTION: (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling. {ECO:0000269\|PubMed:10890433, ECO:0000269\|PubMed:12506336, ECO:0000269\|PubMed:19864601}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for CD36-ANGEL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CD36-ANGEL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CD36-ANGEL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CD36-ANGEL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source