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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD47-CBLB (FusionGDB2 ID:14539)

Fusion Gene Summary for CD47-CBLB

check button Fusion gene summary
Fusion gene informationFusion gene name: CD47-CBLB
Fusion gene ID: 14539
HgeneTgene
Gene symbol

CD47

CBLB

Gene ID

961

868

Gene nameCD47 moleculeCbl proto-oncogene B
SynonymsIAP|MER6|OA3Cbl-b|Nbla00127|RNF56
Cytomap

3q13.12

3q13.11

Type of geneprotein-codingprotein-coding
Descriptionleukocyte surface antigen CD47CD47 antigen (Rh-related antigen, integrin-associated signal transducer)CD47 glycoproteinRh-related antigenantigen identified by monoclonal antibody 1D8antigenic surface determinant protein OA3integrin associated proteiE3 ubiquitin-protein ligase CBL-BCas-Br-M (murine) ecotropic retroviral transforming sequence bCbl proto-oncogene B, E3 ubiquitin protein ligaseCbl proto-oncogene, E3 ubiquitin protein ligase BRING finger protein 56RING-type E3 ubiquitin transferase
Modification date2020031320200327
UniProtAcc

Q08722

Q13191

Ensembl transtripts involved in fusion geneENST00000355354, ENST00000361309, 
ENST00000471694, 		ENST00000403724, 
ENST00000405772, ENST00000545639, 
ENST00000394027, ENST00000407712, 
ENST00000264122, 
Fusion gene scores* DoF score3 X 3 X 3=2713 X 14 X 7=1274
# samples 316
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/1274*10)=-2.99322146736894
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD47 [Title/Abstract] AND CBLB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD47(107789939)-CBLB(105378073), # samples:1
Anticipated loss of major functional domain due to fusion event.CD47-CBLB seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CD47-CBLB seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CD47-CBLB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD47

GO:0008284

positive regulation of cell proliferation

15383453

HgeneCD47

GO:0022409

positive regulation of cell-cell adhesion

15383453

HgeneCD47

GO:0050870

positive regulation of T cell activation

15383453


check buttonFusion gene breakpoints across CD47 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CBLB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GXCD47chr3

107789939

-CBLBchr3

105378073

-


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Fusion Gene ORF analysis for CD47-CBLB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000355354ENST00000403724CD47chr3

107789939

-CBLBchr3

105378073

-
5CDS-intronENST00000355354ENST00000405772CD47chr3

107789939

-CBLBchr3

105378073

-
5CDS-intronENST00000355354ENST00000545639CD47chr3

107789939

-CBLBchr3

105378073

-
5CDS-intronENST00000361309ENST00000403724CD47chr3

107789939

-CBLBchr3

105378073

-
5CDS-intronENST00000361309ENST00000405772CD47chr3

107789939

-CBLBchr3

105378073

-
5CDS-intronENST00000361309ENST00000545639CD47chr3

107789939

-CBLBchr3

105378073

-
Frame-shiftENST00000355354ENST00000394027CD47chr3

107789939

-CBLBchr3

105378073

-
Frame-shiftENST00000355354ENST00000407712CD47chr3

107789939

-CBLBchr3

105378073

-
Frame-shiftENST00000361309ENST00000394027CD47chr3

107789939

-CBLBchr3

105378073

-
Frame-shiftENST00000361309ENST00000407712CD47chr3

107789939

-CBLBchr3

105378073

-
In-frameENST00000355354ENST00000264122CD47chr3

107789939

-CBLBchr3

105378073

-
In-frameENST00000361309ENST00000264122CD47chr3

107789939

-CBLBchr3

105378073

-
intron-3CDSENST00000471694ENST00000264122CD47chr3

107789939

-CBLBchr3

105378073

-
intron-3CDSENST00000471694ENST00000394027CD47chr3

107789939

-CBLBchr3

105378073

-
intron-3CDSENST00000471694ENST00000407712CD47chr3

107789939

-CBLBchr3

105378073

-
intron-intronENST00000471694ENST00000403724CD47chr3

107789939

-CBLBchr3

105378073

-
intron-intronENST00000471694ENST00000405772CD47chr3

107789939

-CBLBchr3

105378073

-
intron-intronENST00000471694ENST00000545639CD47chr3

107789939

-CBLBchr3

105378073

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355354CD47chr3107789939-ENST00000264122CBLBchr3105378073-437660742866274
ENST00000361309CD47chr3107789939-ENST00000264122CBLBchr3105378073-436559631855274

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355354ENST00000264122CD47chr3107789939-CBLBchr3105378073-0.0002896430.9997104
ENST00000361309ENST00000264122CD47chr3107789939-CBLBchr3105378073-0.0002904520.99970955

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Fusion Genomic Features for CD47-CBLB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CD47-CBLB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:107789939/chr3:105378073)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD47

Q08722

CBLB

Q13191

FUNCTION: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. {ECO:0000250, ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:15383453, ECO:0000269|PubMed:7691831}.FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-3919_127163306.0DomainNote=Ig-like V-type
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-31119_127163324.0DomainNote=Ig-like V-type
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-3919_141163306.0Topological domainExtracellular
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-31119_141163324.0Topological domainExtracellular
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-39142_162163306.0TransmembraneHelical
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-311142_162163324.0TransmembraneHelical
TgeneCBLBchr3:107789939chr3:105378073ENST00000403724015219_2320771.0Calcium bindingOntology_term=ECO:0000255
TgeneCBLBchr3:107789939chr3:105378073ENST00000403724015477_9250771.0Compositional biasNote=Pro-rich
TgeneCBLBchr3:107789939chr3:105378073ENST000002641221719931_970896983.0DomainUBA
TgeneCBLBchr3:107789939chr3:105378073ENST0000040372401535_3430771.0DomainCbl-PTB
TgeneCBLBchr3:107789939chr3:105378073ENST00000403724015931_9700771.0DomainUBA
TgeneCBLBchr3:107789939chr3:105378073ENST00000403724015168_2400771.0RegionNote=EF-hand-like
TgeneCBLBchr3:107789939chr3:105378073ENST00000403724015241_3430771.0RegionNote=SH2-like
TgeneCBLBchr3:107789939chr3:105378073ENST00000403724015344_3720771.0RegionNote=Linker
TgeneCBLBchr3:107789939chr3:105378073ENST0000040372401535_1670771.0RegionNote=4H
TgeneCBLBchr3:107789939chr3:105378073ENST00000403724015373_4120771.0Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-39163_176163306.0Topological domainCytoplasmic
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-39198_207163306.0Topological domainExtracellular
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-39229_235163306.0Topological domainCytoplasmic
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-39257_268163306.0Topological domainExtracellular
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-39290_323163306.0Topological domainCytoplasmic
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-311163_176163324.0Topological domainCytoplasmic
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-311198_207163324.0Topological domainExtracellular
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-311229_235163324.0Topological domainCytoplasmic
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-311257_268163324.0Topological domainExtracellular
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-311290_323163324.0Topological domainCytoplasmic
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-39177_197163306.0TransmembraneHelical
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-39208_228163306.0TransmembraneHelical
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-39236_256163306.0TransmembraneHelical
HgeneCD47chr3:107789939chr3:105378073ENST00000355354-39269_289163306.0TransmembraneHelical
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-311177_197163324.0TransmembraneHelical
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-311208_228163324.0TransmembraneHelical
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-311236_256163324.0TransmembraneHelical
HgeneCD47chr3:107789939chr3:105378073ENST00000361309-311269_289163324.0TransmembraneHelical
TgeneCBLBchr3:107789939chr3:105378073ENST000002641221719219_232896983.0Calcium bindingOntology_term=ECO:0000255
TgeneCBLBchr3:107789939chr3:105378073ENST000002641221719477_925896983.0Compositional biasNote=Pro-rich
TgeneCBLBchr3:107789939chr3:105378073ENST00000264122171935_343896983.0DomainCbl-PTB
TgeneCBLBchr3:107789939chr3:105378073ENST000002641221719168_240896983.0RegionNote=EF-hand-like
TgeneCBLBchr3:107789939chr3:105378073ENST000002641221719241_343896983.0RegionNote=SH2-like
TgeneCBLBchr3:107789939chr3:105378073ENST000002641221719344_372896983.0RegionNote=Linker
TgeneCBLBchr3:107789939chr3:105378073ENST00000264122171935_167896983.0RegionNote=4H
TgeneCBLBchr3:107789939chr3:105378073ENST000002641221719373_412896983.0Zinc fingerRING-type


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Fusion Gene Sequence for CD47-CBLB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14539_14539_1_CD47-CBLB_CD47_chr3_107789939_ENST00000355354_CBLB_chr3_105378073_ENST00000264122_length(transcript)=4376nt_BP=607nt
TGGGCAGTGGGTCCTGCCTGTGACGCGCGGCGGCGGTCGGTCCTGCCTGTAACGGCGGCGGCGGCTGCTGCTCCGGACACCTGCGGCGGC
GGCGGCGACCCCGCGGCGGGCGCGGAGATGTGGCCCCTGGTAGCGGCGCTGTTGCTGGGCTCGGCGTGCTGCGGATCAGCTCAGCTACTA
TTTAATAAAACAAAATCTGTAGAATTCACGTTTTGTAATGACACTGTCGTCATTCCATGCTTTGTTACTAATATGGAGGCACAAAACACT
ACTGAAGTATACGTAAAGTGGAAATTTAAAGGAAGAGATATTTACACCTTTGATGGAGCTCTAAACAAGTCCACTGTCCCCACTGACTTT
AGTAGTGCAAAAATTGAAGTCTCACAATTACTAAAAGGAGATGCCTCTTTGAAGATGGATAAGAGTGATGCTGTCTCACACACAGGAAAC
TACACTTGTGAAGTAACAGAATTAACCAGAGAAGGTGAAACGATCATCGAGCTAAAATATCGTGTTGTTTCATGGTTTTCTCCAAATGAA
AATATTCTTATTGTTATTTTCCCAATTTTTGCTATACTCCTGTTCTGGGGACAGTTTGGTATTAAAAATGGTTCACAGGCACCAGCCAGA
CCCCCTAAACCACGACCGCGCAGGACTGCACCAGAAATTCACCACAGAAAACCCCATGGGCCTGAGGCGGCATTGGAAAATGTCGATGCA
AAAATTGCAAAACTCATGGGAGAGGGTTATGCCTTTGAAGAGGTGAAGAGAGCCTTAGAGATAGCCCAGAATAATGTCGAAGTTGCCCGG
AGCATCCTCCGAGAATTTGCCTTCCCTCCTCCAGTATCCCCACGTCTAAATCTATAGCAGCCAGAACTGTAGACACCAAAATGGAAAGCA
ATCGATGTATTCCAAGAGTGTGGAAATAAAGAGAACTGAGATGGAATTCAAGAGAGAAGTGTCTCCTCCTCGTGTAGCAGCTTGAGAAGA
GGCTTGGGAGTGCAGCTTCTCAAAGGAGACCGATGCTTGCTCAGGATGTCGACAGCTGTGGCTTCCTTGTTTTTGCTAGCCATATTTTTA
AATCAGGGTTGAACTGACAAAAATAATTTAAAGACGTTTACTTCCCTTGAACTTTGAACCTGTGAAATGCTTTACCTTGTTTACAGTTTG
GCAAAGTTGCAGTTTGTTCTTGTTTTTAGTTTAGTTTTGTTTTGGTGTTTTGATACCTGTACTGTGTTCTTCACAGACCCTTTGTAGCGT
GGTCAGGTCTGCTGTAACATTTCCCACCAACTCTCTTGCTGTCCACATCAACAGCTAAATCATTTATTCATATGGATCTCTACCATCCCC
ATGCCTTGCCCAGGTCCAGTTCCATTTCTCTCATTCACAAGATGCTTTGAAGGTTCTGATTTTCAACTGATCAAACTAATGCAAAAAAAA
AAAAGTATGTATTCTTCACTACTGAGTTTCTTCTTTGGAAACCATCACTATTGAGAGATGGGAAAAACCTGAATGTATAAAGCATTTATT
TGTCAATAAACTGCCTTTTGTAAGGGGTTTTCACATAACATAGAGGAGCTTCCCTTTTTTGTTTAAGTTTTGTAACCTTTAATCCTCCAT
ATTCTCATGTCTGTCATCCCAGGGGTGTCACAACTGTAAAAATCTACAATATTAGAAAGCAGCTACTACAGATGTGGAAGAGAGAACACT
TGTATAAGACAATGCTGTACTGAAGTTATATAACAAGGTCCCCTGATACTTATGCCTGCATTACTTTGAGGGATGCTGAATGAGAGGACC
ATCTCCCTGAAATATATTAATAATTTTCAGATAAAATTATGAACATAACATACCTTTTCTCAAGTGGAATTAGAGTTCATTTCCCATTTA
AGTGATTACACTCTATCTCCTAAGAGCTGTGGGAACCAGTTCATATTGCAGTGGAAACATTAACTCTTCGTTGCACTGTTGAGTGTCAAG
GCTACTGTGGCAATGTTTTTTGCAAAGTTCTCAGTAATTTTCTCTCTGCAATCAAATTAGAGTTCATATTTAATTTGCAGATTCTCTCAT
TCATTGCTCCACACTGCTTTATCAAATCAGGTGAAAGAAATTAATGTAGTTTTGCCTATTTTACAAAATGGTGGTTGGTTCTTTAAACAC
CATGTTATTACTCTTAATAAATCTACAAATATTTATTGAGCATCTATGATATGCTTGGTGCTGTTAGGCACTGTGTTTTTAAAGCACAAA
CTCTCAAAAGCTGATTCCAGCGTAATGTTTTATTTTTGTTTTTCTGTGTTTTTTATGACAAAGTCTGTCTGATAGACAAAGCCTGGAAGG
TTTCCCCCAGGGCTTTAGAATTTAGAATTAGCTGGTTTTCATTTCAAATGGGAAATTAATGGAGAAATGAGATAAAATCATCTCTGTGTA
AATGCTTGAACCCACAGAAAGTTTTCTAAATATGGACTAATTGTGGGTTTGTGCATATTTCTGTGTCTCCTCTTTTCACTTCACACCCAC
CATGATATAAAAAGATGCATCAGAGAGTGAGCCTGCCTTCAGGACCTGAAAGGACATGACTGAACATCTAGTAGATCTGGTGGAAATTAA
TGTTATACAAAAGACACGTAGACTAAGTTGACCCTGGGAGAGGAGTTAATACATTCCTTTGCAAAGTGACATGTGCCCTTTTTTTGACAG
TCTGGCTTTCATGGTATGAGATGAGGACTCACAGGCCTTGGGTAATTTCTGCTTTTGTATGAATTTTTTCAGATGGTTCTGAGCTGGTTA
TGTCCCTGGAGGGGAATTTTTCATTTGCCTTAGATGTTCTTCCCATGAGTAGGTACATGAGTGAAGTTTCTTACACTTTTAAAATTGCAT
TGGCAAATTTTCTTTTGCTTTATGAACCCCTGTTTTGTCATTATGATTTTTCACTTGTTTTAACAGTTTCAGATGTCACCTTGGAATAGC
ACTGTTTATTTTGGCCTTTTTATGATTGCTGATGATAGGTACAGTCTAAAGGCCAAAAGTTGCCACTTCATTGTGATAACATTGTTGCAA
CATTCCTAATATATTAGAGAATGATGTAAAATAAGAATGTTAGAGAACATAGCACATTCTCATTCAGTTTATAAACAATATTTGAAAATT
TCCAGTGAGAATTAAAAAAGGACTAGTGATGATATAGCAAACCTGGACCTGAAATTTGGGGGTGGGGGGTGGGGGGATATCTGTTTTGCA
GAGAAAATTTACCAGCCTCCAGCAAAATCTCTGCATCTTGTACTCAATAGCAACCATTAGTATTGTCATTTAAAAAGAATGAATCAAAAA
TTCATACGTAATGGAATGAAAAGAGGAAAACTTTCTATTAAACACTGTCAAGAAAGACCCATTGCTATCTATCACCTATGAAATTAAACC
TAAAAAAATTTTTTTTTATTGTAAAAGCGACTGCTCGTTGATGTCTGGAAGTGATCCAGACTTTGTTTCACTGTGATCCAAAAAGTTAGA
CATTCCTTCCATTTCTCAAGATTTGGTAACAATTTTTTTTTAAGTCAGCATTTCATATAATACATAAAATTAAGACAAATTAACTTACTG
ATATGTGGCCAATATCAACCCTTCTCACCCAACCCAAACATGTTCTGGAGATAGAAGGACTTATCCTCAATTATATTCCAGTAAATTTAT
CTCCATAATCTGTTTTATCCCCTAATGTATGATATATCTCACCAAATTTTTCTAGAATTGAATAAAAGCAGTTTTTGCTTAACTTGAATT
TCCTTCCACAAATACAACCTTCAGCTCTTCCCTCTCTGTTTCCCTTTTGCCCACATTGCAAATAGTCTTCATAATAGAACCCTCACTGCA
ACTTAAAAGGGTCCCATTTCTTAACTCAGCATTTCATATACCAAGAACACTTGCAAAGATTTCTTCATAATGTGATTTTTTAATTTTTCA
GTTCCAGAAGCATTTCCTACAGTTCGAACGTTATTTTTTCTCTCAGATTTTCAACTTGAAGCTTTGATTTGCACTGAATTAACTTGGATA
AAATTTTAGTTTCTCTCTTCAGCTAACAGATTTGGAAGCAAATTACAGTATACTTGAATAATTCAGGTACTACCTGTTGACCTGGAATTT
TAGTGATTCTGGGAAAGTTTTCCAGACAAAGACACCAATAGAGTGAAGGGTTTTTTCCCCAATTACTATTTTATTGTTTTTTAAAATGCC
TTTTTAAAACTTGTGTGATGTGGCAAAATAGTCATATGTTCAATTAATTTATATTTTATTCATTCCTTTTCAATTCTGGTTATTATGTAA

>14539_14539_1_CD47-CBLB_CD47_chr3_107789939_ENST00000355354_CBLB_chr3_105378073_ENST00000264122_length(amino acids)=274AA_BP=1
MPVTAAAAAAPDTCGGGGDPAAGAEMWPLVAALLLGSACCGSAQLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDI
YTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNENILIVIFPIFAILL
FWGQFGIKNGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSP

--------------------------------------------------------------
>14539_14539_2_CD47-CBLB_CD47_chr3_107789939_ENST00000361309_CBLB_chr3_105378073_ENST00000264122_length(transcript)=4365nt_BP=596nt
TCCTGCCTGTGACGCGCGGCGGCGGTCGGTCCTGCCTGTAACGGCGGCGGCGGCTGCTGCTCCGGACACCTGCGGCGGCGGCGGCGACCC
CGCGGCGGGCGCGGAGATGTGGCCCCTGGTAGCGGCGCTGTTGCTGGGCTCGGCGTGCTGCGGATCAGCTCAGCTACTATTTAATAAAAC
AAAATCTGTAGAATTCACGTTTTGTAATGACACTGTCGTCATTCCATGCTTTGTTACTAATATGGAGGCACAAAACACTACTGAAGTATA
CGTAAAGTGGAAATTTAAAGGAAGAGATATTTACACCTTTGATGGAGCTCTAAACAAGTCCACTGTCCCCACTGACTTTAGTAGTGCAAA
AATTGAAGTCTCACAATTACTAAAAGGAGATGCCTCTTTGAAGATGGATAAGAGTGATGCTGTCTCACACACAGGAAACTACACTTGTGA
AGTAACAGAATTAACCAGAGAAGGTGAAACGATCATCGAGCTAAAATATCGTGTTGTTTCATGGTTTTCTCCAAATGAAAATATTCTTAT
TGTTATTTTCCCAATTTTTGCTATACTCCTGTTCTGGGGACAGTTTGGTATTAAAAATGGTTCACAGGCACCAGCCAGACCCCCTAAACC
ACGACCGCGCAGGACTGCACCAGAAATTCACCACAGAAAACCCCATGGGCCTGAGGCGGCATTGGAAAATGTCGATGCAAAAATTGCAAA
ACTCATGGGAGAGGGTTATGCCTTTGAAGAGGTGAAGAGAGCCTTAGAGATAGCCCAGAATAATGTCGAAGTTGCCCGGAGCATCCTCCG
AGAATTTGCCTTCCCTCCTCCAGTATCCCCACGTCTAAATCTATAGCAGCCAGAACTGTAGACACCAAAATGGAAAGCAATCGATGTATT
CCAAGAGTGTGGAAATAAAGAGAACTGAGATGGAATTCAAGAGAGAAGTGTCTCCTCCTCGTGTAGCAGCTTGAGAAGAGGCTTGGGAGT
GCAGCTTCTCAAAGGAGACCGATGCTTGCTCAGGATGTCGACAGCTGTGGCTTCCTTGTTTTTGCTAGCCATATTTTTAAATCAGGGTTG
AACTGACAAAAATAATTTAAAGACGTTTACTTCCCTTGAACTTTGAACCTGTGAAATGCTTTACCTTGTTTACAGTTTGGCAAAGTTGCA
GTTTGTTCTTGTTTTTAGTTTAGTTTTGTTTTGGTGTTTTGATACCTGTACTGTGTTCTTCACAGACCCTTTGTAGCGTGGTCAGGTCTG
CTGTAACATTTCCCACCAACTCTCTTGCTGTCCACATCAACAGCTAAATCATTTATTCATATGGATCTCTACCATCCCCATGCCTTGCCC
AGGTCCAGTTCCATTTCTCTCATTCACAAGATGCTTTGAAGGTTCTGATTTTCAACTGATCAAACTAATGCAAAAAAAAAAAAGTATGTA
TTCTTCACTACTGAGTTTCTTCTTTGGAAACCATCACTATTGAGAGATGGGAAAAACCTGAATGTATAAAGCATTTATTTGTCAATAAAC
TGCCTTTTGTAAGGGGTTTTCACATAACATAGAGGAGCTTCCCTTTTTTGTTTAAGTTTTGTAACCTTTAATCCTCCATATTCTCATGTC
TGTCATCCCAGGGGTGTCACAACTGTAAAAATCTACAATATTAGAAAGCAGCTACTACAGATGTGGAAGAGAGAACACTTGTATAAGACA
ATGCTGTACTGAAGTTATATAACAAGGTCCCCTGATACTTATGCCTGCATTACTTTGAGGGATGCTGAATGAGAGGACCATCTCCCTGAA
ATATATTAATAATTTTCAGATAAAATTATGAACATAACATACCTTTTCTCAAGTGGAATTAGAGTTCATTTCCCATTTAAGTGATTACAC
TCTATCTCCTAAGAGCTGTGGGAACCAGTTCATATTGCAGTGGAAACATTAACTCTTCGTTGCACTGTTGAGTGTCAAGGCTACTGTGGC
AATGTTTTTTGCAAAGTTCTCAGTAATTTTCTCTCTGCAATCAAATTAGAGTTCATATTTAATTTGCAGATTCTCTCATTCATTGCTCCA
CACTGCTTTATCAAATCAGGTGAAAGAAATTAATGTAGTTTTGCCTATTTTACAAAATGGTGGTTGGTTCTTTAAACACCATGTTATTAC
TCTTAATAAATCTACAAATATTTATTGAGCATCTATGATATGCTTGGTGCTGTTAGGCACTGTGTTTTTAAAGCACAAACTCTCAAAAGC
TGATTCCAGCGTAATGTTTTATTTTTGTTTTTCTGTGTTTTTTATGACAAAGTCTGTCTGATAGACAAAGCCTGGAAGGTTTCCCCCAGG
GCTTTAGAATTTAGAATTAGCTGGTTTTCATTTCAAATGGGAAATTAATGGAGAAATGAGATAAAATCATCTCTGTGTAAATGCTTGAAC
CCACAGAAAGTTTTCTAAATATGGACTAATTGTGGGTTTGTGCATATTTCTGTGTCTCCTCTTTTCACTTCACACCCACCATGATATAAA
AAGATGCATCAGAGAGTGAGCCTGCCTTCAGGACCTGAAAGGACATGACTGAACATCTAGTAGATCTGGTGGAAATTAATGTTATACAAA
AGACACGTAGACTAAGTTGACCCTGGGAGAGGAGTTAATACATTCCTTTGCAAAGTGACATGTGCCCTTTTTTTGACAGTCTGGCTTTCA
TGGTATGAGATGAGGACTCACAGGCCTTGGGTAATTTCTGCTTTTGTATGAATTTTTTCAGATGGTTCTGAGCTGGTTATGTCCCTGGAG
GGGAATTTTTCATTTGCCTTAGATGTTCTTCCCATGAGTAGGTACATGAGTGAAGTTTCTTACACTTTTAAAATTGCATTGGCAAATTTT
CTTTTGCTTTATGAACCCCTGTTTTGTCATTATGATTTTTCACTTGTTTTAACAGTTTCAGATGTCACCTTGGAATAGCACTGTTTATTT
TGGCCTTTTTATGATTGCTGATGATAGGTACAGTCTAAAGGCCAAAAGTTGCCACTTCATTGTGATAACATTGTTGCAACATTCCTAATA
TATTAGAGAATGATGTAAAATAAGAATGTTAGAGAACATAGCACATTCTCATTCAGTTTATAAACAATATTTGAAAATTTCCAGTGAGAA
TTAAAAAAGGACTAGTGATGATATAGCAAACCTGGACCTGAAATTTGGGGGTGGGGGGTGGGGGGATATCTGTTTTGCAGAGAAAATTTA
CCAGCCTCCAGCAAAATCTCTGCATCTTGTACTCAATAGCAACCATTAGTATTGTCATTTAAAAAGAATGAATCAAAAATTCATACGTAA
TGGAATGAAAAGAGGAAAACTTTCTATTAAACACTGTCAAGAAAGACCCATTGCTATCTATCACCTATGAAATTAAACCTAAAAAAATTT
TTTTTTATTGTAAAAGCGACTGCTCGTTGATGTCTGGAAGTGATCCAGACTTTGTTTCACTGTGATCCAAAAAGTTAGACATTCCTTCCA
TTTCTCAAGATTTGGTAACAATTTTTTTTTAAGTCAGCATTTCATATAATACATAAAATTAAGACAAATTAACTTACTGATATGTGGCCA
ATATCAACCCTTCTCACCCAACCCAAACATGTTCTGGAGATAGAAGGACTTATCCTCAATTATATTCCAGTAAATTTATCTCCATAATCT
GTTTTATCCCCTAATGTATGATATATCTCACCAAATTTTTCTAGAATTGAATAAAAGCAGTTTTTGCTTAACTTGAATTTCCTTCCACAA
ATACAACCTTCAGCTCTTCCCTCTCTGTTTCCCTTTTGCCCACATTGCAAATAGTCTTCATAATAGAACCCTCACTGCAACTTAAAAGGG
TCCCATTTCTTAACTCAGCATTTCATATACCAAGAACACTTGCAAAGATTTCTTCATAATGTGATTTTTTAATTTTTCAGTTCCAGAAGC
ATTTCCTACAGTTCGAACGTTATTTTTTCTCTCAGATTTTCAACTTGAAGCTTTGATTTGCACTGAATTAACTTGGATAAAATTTTAGTT
TCTCTCTTCAGCTAACAGATTTGGAAGCAAATTACAGTATACTTGAATAATTCAGGTACTACCTGTTGACCTGGAATTTTAGTGATTCTG
GGAAAGTTTTCCAGACAAAGACACCAATAGAGTGAAGGGTTTTTTCCCCAATTACTATTTTATTGTTTTTTAAAATGCCTTTTTAAAACT
TGTGTGATGTGGCAAAATAGTCATATGTTCAATTAATTTATATTTTATTCATTCCTTTTCAATTCTGGTTATTATGTAACCTCAAGTACT

>14539_14539_2_CD47-CBLB_CD47_chr3_107789939_ENST00000361309_CBLB_chr3_105378073_ENST00000264122_length(amino acids)=274AA_BP=1
MPVTAAAAAAPDTCGGGGDPAAGAEMWPLVAALLLGSACCGSAQLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDI
YTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNENILIVIFPIFAILL
FWGQFGIKNGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSP

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Fusion Gene PPI Analysis for CD47-CBLB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCBLBchr3:107789939chr3:105378073ENST00000403724015891_9270771.0SH3KBP1
TgeneCBLBchr3:107789939chr3:105378073ENST00000403724015543_5680771.0VAV1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCBLBchr3:107789939chr3:105378073ENST000002641221719891_927896.3333333333334983.0SH3KBP1
TgeneCBLBchr3:107789939chr3:105378073ENST000002641221719543_568896.3333333333334983.0VAV1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD47-CBLB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD47-CBLB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource