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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD63-RPS5 (FusionGDB2 ID:14597)

Fusion Gene Summary for CD63-RPS5

check button Fusion gene summary
Fusion gene informationFusion gene name: CD63-RPS5
Fusion gene ID: 14597
HgeneTgene
Gene symbol

CD63

RPS5

Gene ID

967

6193

Gene nameCD63 moleculeribosomal protein S5
SynonymsLAMP-3|ME491|MLA1|OMA81H|TSPAN30S5
Cytomap

12q13.2

19q13.43

Type of geneprotein-codingprotein-coding
DescriptionCD63 antigenCD63 antigen (melanoma 1 antigen)granulophysinlysosomal-associated membrane protein 3lysosome-associated membrane glycoprotein 3melanoma-associated antigen ME491melanoma-associated antigen MLA1ocular melanoma-associated antigentetraspa40S ribosomal protein S5small ribosomal subunit protein uS7
Modification date2020032720200313
UniProtAcc

P08962

.
Ensembl transtripts involved in fusion geneENST00000257857, ENST00000420846, 
ENST00000546939, ENST00000548160, 
ENST00000548898, ENST00000549117, 
ENST00000550776, ENST00000552067, 
ENST00000552692, ENST00000552754, 
ENST00000601521, ENST00000196551, 
ENST00000596046, ENST00000598098, 
ENST00000598495, 
Fusion gene scores* DoF score23 X 19 X 9=393313 X 13 X 4=676
# samples 2313
** MAII scorelog2(23/3933*10)=-4.09592441999854
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/676*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD63 [Title/Abstract] AND RPS5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD63(56119614)-RPS5(58904396), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD63

GO:0034613

cellular protein localization

15647390

HgeneCD63

GO:1901379

regulation of potassium ion transmembrane transport

15647390


check buttonFusion gene breakpoints across CD63 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RPS5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACF128579CD63chr12

56119614

-RPS5chr19

58904396

+


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Fusion Gene ORF analysis for CD63-RPS5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000257857ENST00000601521CD63chr12

56119614

-RPS5chr19

58904396

+
intron-3CDSENST00000420846ENST00000601521CD63chr12

56119614

-RPS5chr19

58904396

+
intron-3CDSENST00000546939ENST00000601521CD63chr12

56119614

-RPS5chr19

58904396

+
intron-3CDSENST00000548160ENST00000601521CD63chr12

56119614

-RPS5chr19

58904396

+
intron-3CDSENST00000548898ENST00000601521CD63chr12

56119614

-RPS5chr19

58904396

+
intron-3CDSENST00000549117ENST00000601521CD63chr12

56119614

-RPS5chr19

58904396

+
intron-3CDSENST00000550776ENST00000601521CD63chr12

56119614

-RPS5chr19

58904396

+
intron-3CDSENST00000552067ENST00000601521CD63chr12

56119614

-RPS5chr19

58904396

+
intron-3CDSENST00000552692ENST00000601521CD63chr12

56119614

-RPS5chr19

58904396

+
intron-3CDSENST00000552754ENST00000601521CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000257857ENST00000196551CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000257857ENST00000596046CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000257857ENST00000598098CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000257857ENST00000598495CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000420846ENST00000196551CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000420846ENST00000596046CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000420846ENST00000598098CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000420846ENST00000598495CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000546939ENST00000196551CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000546939ENST00000596046CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000546939ENST00000598098CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000546939ENST00000598495CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000548160ENST00000196551CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000548160ENST00000596046CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000548160ENST00000598098CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000548160ENST00000598495CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000548898ENST00000196551CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000548898ENST00000596046CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000548898ENST00000598098CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000548898ENST00000598495CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000549117ENST00000196551CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000549117ENST00000596046CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000549117ENST00000598098CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000549117ENST00000598495CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000550776ENST00000196551CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000550776ENST00000596046CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000550776ENST00000598098CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000550776ENST00000598495CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552067ENST00000196551CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552067ENST00000596046CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552067ENST00000598098CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552067ENST00000598495CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552692ENST00000196551CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552692ENST00000596046CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552692ENST00000598098CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552692ENST00000598495CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552754ENST00000196551CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552754ENST00000596046CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552754ENST00000598098CD63chr12

56119614

-RPS5chr19

58904396

+
intron-intronENST00000552754ENST00000598495CD63chr12

56119614

-RPS5chr19

58904396

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CD63-RPS5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CD63-RPS5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:56119614/:58904396)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD63

P08962

.
FUNCTION: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:21803846, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CD63-RPS5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CD63-RPS5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD63-RPS5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD63-RPS5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource