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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACPP-SAFB2 (FusionGDB2 ID:1463)

Fusion Gene Summary for ACPP-SAFB2

check button Fusion gene summary
Fusion gene informationFusion gene name: ACPP-SAFB2
Fusion gene ID: 1463
HgeneTgene
Gene symbol

ACPP

SAFB2

Gene ID

55

9667

Gene nameacid phosphatase 3scaffold attachment factor B2
Synonyms5'-NT|ACP-3|ACPP|TM-PAP-
Cytomap

3q22.1

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionprostatic acid phosphataseTMPaseacid phosphatase, prostateecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatasescaffold attachment factor B2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000489084, ENST00000336375, 
ENST00000351273, ENST00000475741, 
ENST00000252542, ENST00000591310, 
Fusion gene scores* DoF score28 X 17 X 4=19048 X 8 X 5=320
# samples 319
** MAII scorelog2(31/1904*10)=-2.61869335803371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACPP [Title/Abstract] AND SAFB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACPP(132036420)-SAFB2(5616346), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACPP

GO:0046085

adenosine metabolic process

18940592


check buttonFusion gene breakpoints across ACPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SAFB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-7233-01AACPPchr3

132036419

+SAFB2chr19

5616345

-
ChimerDB4PRADTCGA-HC-7233-01AACPPchr3

132036420

-SAFB2chr19

5616346

-
ChimerDB4PRADTCGA-HC-7233-01AACPPchr3

132036420

+SAFB2chr19

5616346

-
ChimerDB4PRADTCGA-HC-7233ACPPchr3

132036420

+SAFB2chr19

5616346

-


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Fusion Gene ORF analysis for ACPP-SAFB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000489084ENST00000252542ACPPchr3

132036419

+SAFB2chr19

5616345

-
3UTR-3CDSENST00000489084ENST00000252542ACPPchr3

132036420

+SAFB2chr19

5616346

-
3UTR-intronENST00000489084ENST00000591310ACPPchr3

132036419

+SAFB2chr19

5616345

-
3UTR-intronENST00000489084ENST00000591310ACPPchr3

132036420

+SAFB2chr19

5616346

-
5CDS-intronENST00000336375ENST00000591310ACPPchr3

132036419

+SAFB2chr19

5616345

-
5CDS-intronENST00000336375ENST00000591310ACPPchr3

132036420

+SAFB2chr19

5616346

-
5CDS-intronENST00000351273ENST00000591310ACPPchr3

132036419

+SAFB2chr19

5616345

-
5CDS-intronENST00000351273ENST00000591310ACPPchr3

132036420

+SAFB2chr19

5616346

-
5CDS-intronENST00000475741ENST00000591310ACPPchr3

132036419

+SAFB2chr19

5616345

-
5CDS-intronENST00000475741ENST00000591310ACPPchr3

132036420

+SAFB2chr19

5616346

-
In-frameENST00000336375ENST00000252542ACPPchr3

132036419

+SAFB2chr19

5616345

-
In-frameENST00000336375ENST00000252542ACPPchr3

132036420

+SAFB2chr19

5616346

-
In-frameENST00000351273ENST00000252542ACPPchr3

132036419

+SAFB2chr19

5616345

-
In-frameENST00000351273ENST00000252542ACPPchr3

132036420

+SAFB2chr19

5616346

-
In-frameENST00000475741ENST00000252542ACPPchr3

132036419

+SAFB2chr19

5616345

-
In-frameENST00000475741ENST00000252542ACPPchr3

132036420

+SAFB2chr19

5616346

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336375ACPPchr3132036420+ENST00000252542SAFB2chr195616346-2977210662732888
ENST00000475741ACPPchr3132036420+ENST00000252542SAFB2chr195616346-2938171272693888
ENST00000351273ACPPchr3132036420+ENST00000252542SAFB2chr195616346-2937170262692888
ENST00000336375ACPPchr3132036419+ENST00000252542SAFB2chr195616345-2977210662732888
ENST00000475741ACPPchr3132036419+ENST00000252542SAFB2chr195616345-2938171272693888
ENST00000351273ACPPchr3132036419+ENST00000252542SAFB2chr195616345-2937170262692888

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336375ENST00000252542ACPPchr3132036420+SAFB2chr195616346-0.0044241780.9955758
ENST00000475741ENST00000252542ACPPchr3132036420+SAFB2chr195616346-0.0046996930.9953003
ENST00000351273ENST00000252542ACPPchr3132036420+SAFB2chr195616346-0.0046691910.99533075
ENST00000336375ENST00000252542ACPPchr3132036419+SAFB2chr195616345-0.0044241780.9955758
ENST00000475741ENST00000252542ACPPchr3132036419+SAFB2chr195616345-0.0046996930.9953003
ENST00000351273ENST00000252542ACPPchr3132036419+SAFB2chr195616345-0.0046691910.99533075

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Fusion Genomic Features for ACPP-SAFB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACPP-SAFB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:132036420/chr19:5616346)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSAFB2chr3:132036419chr19:5616345ENST00000252542221482_545113954.0Compositional biasNote=Lys-rich
TgeneSAFB2chr3:132036419chr19:5616345ENST00000252542221619_724113954.0Compositional biasNote=Glu-rich
TgeneSAFB2chr3:132036419chr19:5616345ENST00000252542221621_788113954.0Compositional biasNote=Arg-rich
TgeneSAFB2chr3:132036419chr19:5616345ENST00000252542221792_926113954.0Compositional biasNote=Gly-rich
TgeneSAFB2chr3:132036420chr19:5616346ENST00000252542221482_545113954.0Compositional biasNote=Lys-rich
TgeneSAFB2chr3:132036420chr19:5616346ENST00000252542221619_724113954.0Compositional biasNote=Glu-rich
TgeneSAFB2chr3:132036420chr19:5616346ENST00000252542221621_788113954.0Compositional biasNote=Arg-rich
TgeneSAFB2chr3:132036420chr19:5616346ENST00000252542221792_926113954.0Compositional biasNote=Gly-rich
TgeneSAFB2chr3:132036419chr19:5616345ENST00000252542221407_485113954.0DomainRRM
TgeneSAFB2chr3:132036420chr19:5616346ENST00000252542221407_485113954.0DomainRRM
TgeneSAFB2chr3:132036419chr19:5616345ENST00000252542221713_730113954.0MotifNuclear localization signal
TgeneSAFB2chr3:132036420chr19:5616346ENST00000252542221713_730113954.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSAFB2chr3:132036419chr19:5616345ENST0000025254222130_64113954.0DomainSAP
TgeneSAFB2chr3:132036420chr19:5616346ENST0000025254222130_64113954.0DomainSAP


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Fusion Gene Sequence for ACPP-SAFB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1463_1463_1_ACPP-SAFB2_ACPP_chr3_132036419_ENST00000336375_SAFB2_chr19_5616345_ENST00000252542_length(transcript)=2977nt_BP=210nt
TCAATCCCTTAATTAAATAGCTTCCCCTCTACAGGCTTTTGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAAC
ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA
CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGAGGACATGGAAGCAAGTCTGGAGAACCTGCAGAATATGGGCATGATGGACATGAGTGTG
CTAGACGAAACTGAAGTGGCGAATAGCAGTGCTCCAGATTTTGGGGAGGATGGCACGGACGGCCTTCTCGATTCCTTTTGTGATAGTAAA
GAATACGTGGCTGCACAGCTGAGACAGCTCCCGGCTCAGCCCCCAGAGCATGCTGTGGATGGGGAAGGATTTAAGAACACTTTGGAAACT
TCATCGTTGAACTTCAAAGTAACTCCGGACATTGAAGAATCCCTTTTGGAGCCAGAAAATGAGAAAATACTCGACATTTTGGGGGAAACT
TGTAAATCTGAGCCAGTAAAAGAAGAAAGTTCCGAGCTGGAGCAGCCATTTGCACAGGACACAAGTAGCGTGGGGCCAGACAGAAAGCTT
GCGGAGGAAGAGGACCTATTTGACAGCGCCCATCCGGAAGAGGGTGATTTAGATTTGGCCAGCGAGTCAACAGCACACGCTCAGTCGAGC
AAGGCAGACAGCCTGTTAGCGGTAGTGAAAAGGGAGCCCGCGGAGCAGCCAGGCGATGGCGAGAGGACGGACTGTGAGCCTGTAGGGCTA
GAGCCGGCAGTTGAGCAGAGTAGTGCGGCCTCCGAGCTCGCGGAGGCCTCTAGCGAGGAGCTCGCAGAAGCACCCACGGAAGCCCCAAGC
CCAGAAGCCAGAGATAGCAAAGAAGACGGGAGGAAGTTTGATTTTGACGCTTGTAATGAAGTCCCTCCGGCTCCTAAAGAGTCCTCAACC
AGTGAGGGCGCTGATCAGAAAATGAGCTCTTTTAAGGAAGAAAAAGATATAAAGCCAATCATTAAAGATGAAAAAGGTCGGGTCGGCAGC
GGTTCTGGTCGGAACCTGTGGGTCAGCGGGCTGTCCTCCACAACACGCGCTACGGATCTCAAGAACCTTTTCAGCAAGTATGGGAAGGTT
GTCGGGGCCAAAGTGGTAACGAACGCCCGCAGCCCGGGGGCTCGATGCTATGGATTCGTCACCATGTCGACATCTGACGAGGCGACCAAG
TGCATCAGCCATCTCCACAGAACTGAGCTGCATGGACGAATGATCTCCGTAGAGAAGGCCAAAAATGAGCCTGCTGGGAAAAAGCTTTCC
GACAGAAAAGAGTGCGAAGTGAAGAAGGAAAAATTATCGAGTGTCGACAGACATCATTCTGTGGAGATCAAAATTGAAAAAACTGTAATT
AAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGA
CCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATT
AGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCG
TTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAG
CAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAG
CGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAG
CGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGAC
CTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCAC
CGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGAC
CACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGG
GGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGG
CTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGG
GGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAG
GGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCC
CCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCACTCGCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAG
GGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGTAAATCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTT
TTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAAATCAAGGTTTCTGTTAACGAGGCATTCCATTTTCCATTAATAAAGTTTACC

>1463_1463_1_ACPP-SAFB2_ACPP_chr3_132036419_ENST00000336375_SAFB2_chr19_5616345_ENST00000252542_length(amino acids)=888AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLEDMEASLENLQNMGMMDMSVLDETEVANSSAPDFGEDGTDGL
LDSFCDSKEYVAAQLRQLPAQPPEHAVDGEGFKNTLETSSLNFKVTPDIEESLLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTS
SVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELA
EAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSFKEEKDIKPIIKDEKGRVGSGSGRNLWVSGLSSTTRATDLKN
LFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVE
IKIEKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSES
KEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVE
RERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRRE
GSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREH

--------------------------------------------------------------
>1463_1463_2_ACPP-SAFB2_ACPP_chr3_132036419_ENST00000351273_SAFB2_chr19_5616345_ENST00000252542_length(transcript)=2937nt_BP=170nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGAGGACATGG
AAGCAAGTCTGGAGAACCTGCAGAATATGGGCATGATGGACATGAGTGTGCTAGACGAAACTGAAGTGGCGAATAGCAGTGCTCCAGATT
TTGGGGAGGATGGCACGGACGGCCTTCTCGATTCCTTTTGTGATAGTAAAGAATACGTGGCTGCACAGCTGAGACAGCTCCCGGCTCAGC
CCCCAGAGCATGCTGTGGATGGGGAAGGATTTAAGAACACTTTGGAAACTTCATCGTTGAACTTCAAAGTAACTCCGGACATTGAAGAAT
CCCTTTTGGAGCCAGAAAATGAGAAAATACTCGACATTTTGGGGGAAACTTGTAAATCTGAGCCAGTAAAAGAAGAAAGTTCCGAGCTGG
AGCAGCCATTTGCACAGGACACAAGTAGCGTGGGGCCAGACAGAAAGCTTGCGGAGGAAGAGGACCTATTTGACAGCGCCCATCCGGAAG
AGGGTGATTTAGATTTGGCCAGCGAGTCAACAGCACACGCTCAGTCGAGCAAGGCAGACAGCCTGTTAGCGGTAGTGAAAAGGGAGCCCG
CGGAGCAGCCAGGCGATGGCGAGAGGACGGACTGTGAGCCTGTAGGGCTAGAGCCGGCAGTTGAGCAGAGTAGTGCGGCCTCCGAGCTCG
CGGAGGCCTCTAGCGAGGAGCTCGCAGAAGCACCCACGGAAGCCCCAAGCCCAGAAGCCAGAGATAGCAAAGAAGACGGGAGGAAGTTTG
ATTTTGACGCTTGTAATGAAGTCCCTCCGGCTCCTAAAGAGTCCTCAACCAGTGAGGGCGCTGATCAGAAAATGAGCTCTTTTAAGGAAG
AAAAAGATATAAAGCCAATCATTAAAGATGAAAAAGGTCGGGTCGGCAGCGGTTCTGGTCGGAACCTGTGGGTCAGCGGGCTGTCCTCCA
CAACACGCGCTACGGATCTCAAGAACCTTTTCAGCAAGTATGGGAAGGTTGTCGGGGCCAAAGTGGTAACGAACGCCCGCAGCCCGGGGG
CTCGATGCTATGGATTCGTCACCATGTCGACATCTGACGAGGCGACCAAGTGCATCAGCCATCTCCACAGAACTGAGCTGCATGGACGAA
TGATCTCCGTAGAGAAGGCCAAAAATGAGCCTGCTGGGAAAAAGCTTTCCGACAGAAAAGAGTGCGAAGTGAAGAAGGAAAAATTATCGA
GTGTCGACAGACATCATTCTGTGGAGATCAAAATTGAAAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGC
CTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAG
GAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCA
AGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGA
GGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGC
GGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGC
TGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGG
AGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGC
GTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACC
AGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCC
ACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGC
TGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGG
ACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCC
GCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAG
TGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCAC
TCGCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGTA
AATCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAAA

>1463_1463_2_ACPP-SAFB2_ACPP_chr3_132036419_ENST00000351273_SAFB2_chr19_5616345_ENST00000252542_length(amino acids)=888AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLEDMEASLENLQNMGMMDMSVLDETEVANSSAPDFGEDGTDGL
LDSFCDSKEYVAAQLRQLPAQPPEHAVDGEGFKNTLETSSLNFKVTPDIEESLLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTS
SVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELA
EAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSFKEEKDIKPIIKDEKGRVGSGSGRNLWVSGLSSTTRATDLKN
LFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVE
IKIEKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSES
KEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVE
RERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRRE
GSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREH

--------------------------------------------------------------
>1463_1463_3_ACPP-SAFB2_ACPP_chr3_132036419_ENST00000475741_SAFB2_chr19_5616345_ENST00000252542_length(transcript)=2938nt_BP=171nt
TGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGC
CTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGAGGACATG
GAAGCAAGTCTGGAGAACCTGCAGAATATGGGCATGATGGACATGAGTGTGCTAGACGAAACTGAAGTGGCGAATAGCAGTGCTCCAGAT
TTTGGGGAGGATGGCACGGACGGCCTTCTCGATTCCTTTTGTGATAGTAAAGAATACGTGGCTGCACAGCTGAGACAGCTCCCGGCTCAG
CCCCCAGAGCATGCTGTGGATGGGGAAGGATTTAAGAACACTTTGGAAACTTCATCGTTGAACTTCAAAGTAACTCCGGACATTGAAGAA
TCCCTTTTGGAGCCAGAAAATGAGAAAATACTCGACATTTTGGGGGAAACTTGTAAATCTGAGCCAGTAAAAGAAGAAAGTTCCGAGCTG
GAGCAGCCATTTGCACAGGACACAAGTAGCGTGGGGCCAGACAGAAAGCTTGCGGAGGAAGAGGACCTATTTGACAGCGCCCATCCGGAA
GAGGGTGATTTAGATTTGGCCAGCGAGTCAACAGCACACGCTCAGTCGAGCAAGGCAGACAGCCTGTTAGCGGTAGTGAAAAGGGAGCCC
GCGGAGCAGCCAGGCGATGGCGAGAGGACGGACTGTGAGCCTGTAGGGCTAGAGCCGGCAGTTGAGCAGAGTAGTGCGGCCTCCGAGCTC
GCGGAGGCCTCTAGCGAGGAGCTCGCAGAAGCACCCACGGAAGCCCCAAGCCCAGAAGCCAGAGATAGCAAAGAAGACGGGAGGAAGTTT
GATTTTGACGCTTGTAATGAAGTCCCTCCGGCTCCTAAAGAGTCCTCAACCAGTGAGGGCGCTGATCAGAAAATGAGCTCTTTTAAGGAA
GAAAAAGATATAAAGCCAATCATTAAAGATGAAAAAGGTCGGGTCGGCAGCGGTTCTGGTCGGAACCTGTGGGTCAGCGGGCTGTCCTCC
ACAACACGCGCTACGGATCTCAAGAACCTTTTCAGCAAGTATGGGAAGGTTGTCGGGGCCAAAGTGGTAACGAACGCCCGCAGCCCGGGG
GCTCGATGCTATGGATTCGTCACCATGTCGACATCTGACGAGGCGACCAAGTGCATCAGCCATCTCCACAGAACTGAGCTGCATGGACGA
ATGATCTCCGTAGAGAAGGCCAAAAATGAGCCTGCTGGGAAAAAGCTTTCCGACAGAAAAGAGTGCGAAGTGAAGAAGGAAAAATTATCG
AGTGTCGACAGACATCATTCTGTGGAGATCAAAATTGAAAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAG
CCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGA
GGAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCC
AAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAG
AGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAG
CGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGG
CTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAG
GAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAG
CGTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTAC
CAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGC
CACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGG
CTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATG
GACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGC
CGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGA
GTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCA
CTCGCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGT
AAATCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAA

>1463_1463_3_ACPP-SAFB2_ACPP_chr3_132036419_ENST00000475741_SAFB2_chr19_5616345_ENST00000252542_length(amino acids)=888AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLEDMEASLENLQNMGMMDMSVLDETEVANSSAPDFGEDGTDGL
LDSFCDSKEYVAAQLRQLPAQPPEHAVDGEGFKNTLETSSLNFKVTPDIEESLLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTS
SVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELA
EAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSFKEEKDIKPIIKDEKGRVGSGSGRNLWVSGLSSTTRATDLKN
LFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVE
IKIEKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSES
KEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVE
RERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRRE
GSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREH

--------------------------------------------------------------
>1463_1463_4_ACPP-SAFB2_ACPP_chr3_132036420_ENST00000336375_SAFB2_chr19_5616346_ENST00000252542_length(transcript)=2977nt_BP=210nt
TCAATCCCTTAATTAAATAGCTTCCCCTCTACAGGCTTTTGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAAC
ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA
CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGAGGACATGGAAGCAAGTCTGGAGAACCTGCAGAATATGGGCATGATGGACATGAGTGTG
CTAGACGAAACTGAAGTGGCGAATAGCAGTGCTCCAGATTTTGGGGAGGATGGCACGGACGGCCTTCTCGATTCCTTTTGTGATAGTAAA
GAATACGTGGCTGCACAGCTGAGACAGCTCCCGGCTCAGCCCCCAGAGCATGCTGTGGATGGGGAAGGATTTAAGAACACTTTGGAAACT
TCATCGTTGAACTTCAAAGTAACTCCGGACATTGAAGAATCCCTTTTGGAGCCAGAAAATGAGAAAATACTCGACATTTTGGGGGAAACT
TGTAAATCTGAGCCAGTAAAAGAAGAAAGTTCCGAGCTGGAGCAGCCATTTGCACAGGACACAAGTAGCGTGGGGCCAGACAGAAAGCTT
GCGGAGGAAGAGGACCTATTTGACAGCGCCCATCCGGAAGAGGGTGATTTAGATTTGGCCAGCGAGTCAACAGCACACGCTCAGTCGAGC
AAGGCAGACAGCCTGTTAGCGGTAGTGAAAAGGGAGCCCGCGGAGCAGCCAGGCGATGGCGAGAGGACGGACTGTGAGCCTGTAGGGCTA
GAGCCGGCAGTTGAGCAGAGTAGTGCGGCCTCCGAGCTCGCGGAGGCCTCTAGCGAGGAGCTCGCAGAAGCACCCACGGAAGCCCCAAGC
CCAGAAGCCAGAGATAGCAAAGAAGACGGGAGGAAGTTTGATTTTGACGCTTGTAATGAAGTCCCTCCGGCTCCTAAAGAGTCCTCAACC
AGTGAGGGCGCTGATCAGAAAATGAGCTCTTTTAAGGAAGAAAAAGATATAAAGCCAATCATTAAAGATGAAAAAGGTCGGGTCGGCAGC
GGTTCTGGTCGGAACCTGTGGGTCAGCGGGCTGTCCTCCACAACACGCGCTACGGATCTCAAGAACCTTTTCAGCAAGTATGGGAAGGTT
GTCGGGGCCAAAGTGGTAACGAACGCCCGCAGCCCGGGGGCTCGATGCTATGGATTCGTCACCATGTCGACATCTGACGAGGCGACCAAG
TGCATCAGCCATCTCCACAGAACTGAGCTGCATGGACGAATGATCTCCGTAGAGAAGGCCAAAAATGAGCCTGCTGGGAAAAAGCTTTCC
GACAGAAAAGAGTGCGAAGTGAAGAAGGAAAAATTATCGAGTGTCGACAGACATCATTCTGTGGAGATCAAAATTGAAAAAACTGTAATT
AAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGA
CCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATT
AGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCG
TTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAG
CAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAG
CGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAG
CGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGAC
CTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCAC
CGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGAC
CACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGG
GGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGG
CTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGG
GGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAG
GGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCC
CCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCACTCGCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAG
GGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGTAAATCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTT
TTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAAATCAAGGTTTCTGTTAACGAGGCATTCCATTTTCCATTAATAAAGTTTACC

>1463_1463_4_ACPP-SAFB2_ACPP_chr3_132036420_ENST00000336375_SAFB2_chr19_5616346_ENST00000252542_length(amino acids)=888AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLEDMEASLENLQNMGMMDMSVLDETEVANSSAPDFGEDGTDGL
LDSFCDSKEYVAAQLRQLPAQPPEHAVDGEGFKNTLETSSLNFKVTPDIEESLLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTS
SVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELA
EAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSFKEEKDIKPIIKDEKGRVGSGSGRNLWVSGLSSTTRATDLKN
LFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVE
IKIEKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSES
KEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVE
RERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRRE
GSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREH

--------------------------------------------------------------
>1463_1463_5_ACPP-SAFB2_ACPP_chr3_132036420_ENST00000351273_SAFB2_chr19_5616346_ENST00000252542_length(transcript)=2937nt_BP=170nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGAGGACATGG
AAGCAAGTCTGGAGAACCTGCAGAATATGGGCATGATGGACATGAGTGTGCTAGACGAAACTGAAGTGGCGAATAGCAGTGCTCCAGATT
TTGGGGAGGATGGCACGGACGGCCTTCTCGATTCCTTTTGTGATAGTAAAGAATACGTGGCTGCACAGCTGAGACAGCTCCCGGCTCAGC
CCCCAGAGCATGCTGTGGATGGGGAAGGATTTAAGAACACTTTGGAAACTTCATCGTTGAACTTCAAAGTAACTCCGGACATTGAAGAAT
CCCTTTTGGAGCCAGAAAATGAGAAAATACTCGACATTTTGGGGGAAACTTGTAAATCTGAGCCAGTAAAAGAAGAAAGTTCCGAGCTGG
AGCAGCCATTTGCACAGGACACAAGTAGCGTGGGGCCAGACAGAAAGCTTGCGGAGGAAGAGGACCTATTTGACAGCGCCCATCCGGAAG
AGGGTGATTTAGATTTGGCCAGCGAGTCAACAGCACACGCTCAGTCGAGCAAGGCAGACAGCCTGTTAGCGGTAGTGAAAAGGGAGCCCG
CGGAGCAGCCAGGCGATGGCGAGAGGACGGACTGTGAGCCTGTAGGGCTAGAGCCGGCAGTTGAGCAGAGTAGTGCGGCCTCCGAGCTCG
CGGAGGCCTCTAGCGAGGAGCTCGCAGAAGCACCCACGGAAGCCCCAAGCCCAGAAGCCAGAGATAGCAAAGAAGACGGGAGGAAGTTTG
ATTTTGACGCTTGTAATGAAGTCCCTCCGGCTCCTAAAGAGTCCTCAACCAGTGAGGGCGCTGATCAGAAAATGAGCTCTTTTAAGGAAG
AAAAAGATATAAAGCCAATCATTAAAGATGAAAAAGGTCGGGTCGGCAGCGGTTCTGGTCGGAACCTGTGGGTCAGCGGGCTGTCCTCCA
CAACACGCGCTACGGATCTCAAGAACCTTTTCAGCAAGTATGGGAAGGTTGTCGGGGCCAAAGTGGTAACGAACGCCCGCAGCCCGGGGG
CTCGATGCTATGGATTCGTCACCATGTCGACATCTGACGAGGCGACCAAGTGCATCAGCCATCTCCACAGAACTGAGCTGCATGGACGAA
TGATCTCCGTAGAGAAGGCCAAAAATGAGCCTGCTGGGAAAAAGCTTTCCGACAGAAAAGAGTGCGAAGTGAAGAAGGAAAAATTATCGA
GTGTCGACAGACATCATTCTGTGGAGATCAAAATTGAAAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGC
CTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAG
GAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCA
AGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGA
GGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGC
GGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGC
TGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGG
AGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGC
GTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACC
AGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCC
ACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGC
TGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGG
ACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCC
GCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAG
TGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCAC
TCGCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGTA
AATCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAAA

>1463_1463_5_ACPP-SAFB2_ACPP_chr3_132036420_ENST00000351273_SAFB2_chr19_5616346_ENST00000252542_length(amino acids)=888AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLEDMEASLENLQNMGMMDMSVLDETEVANSSAPDFGEDGTDGL
LDSFCDSKEYVAAQLRQLPAQPPEHAVDGEGFKNTLETSSLNFKVTPDIEESLLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTS
SVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELA
EAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSFKEEKDIKPIIKDEKGRVGSGSGRNLWVSGLSSTTRATDLKN
LFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVE
IKIEKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSES
KEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVE
RERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRRE
GSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREH

--------------------------------------------------------------
>1463_1463_6_ACPP-SAFB2_ACPP_chr3_132036420_ENST00000475741_SAFB2_chr19_5616346_ENST00000252542_length(transcript)=2938nt_BP=171nt
TGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGC
CTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGAGGACATG
GAAGCAAGTCTGGAGAACCTGCAGAATATGGGCATGATGGACATGAGTGTGCTAGACGAAACTGAAGTGGCGAATAGCAGTGCTCCAGAT
TTTGGGGAGGATGGCACGGACGGCCTTCTCGATTCCTTTTGTGATAGTAAAGAATACGTGGCTGCACAGCTGAGACAGCTCCCGGCTCAG
CCCCCAGAGCATGCTGTGGATGGGGAAGGATTTAAGAACACTTTGGAAACTTCATCGTTGAACTTCAAAGTAACTCCGGACATTGAAGAA
TCCCTTTTGGAGCCAGAAAATGAGAAAATACTCGACATTTTGGGGGAAACTTGTAAATCTGAGCCAGTAAAAGAAGAAAGTTCCGAGCTG
GAGCAGCCATTTGCACAGGACACAAGTAGCGTGGGGCCAGACAGAAAGCTTGCGGAGGAAGAGGACCTATTTGACAGCGCCCATCCGGAA
GAGGGTGATTTAGATTTGGCCAGCGAGTCAACAGCACACGCTCAGTCGAGCAAGGCAGACAGCCTGTTAGCGGTAGTGAAAAGGGAGCCC
GCGGAGCAGCCAGGCGATGGCGAGAGGACGGACTGTGAGCCTGTAGGGCTAGAGCCGGCAGTTGAGCAGAGTAGTGCGGCCTCCGAGCTC
GCGGAGGCCTCTAGCGAGGAGCTCGCAGAAGCACCCACGGAAGCCCCAAGCCCAGAAGCCAGAGATAGCAAAGAAGACGGGAGGAAGTTT
GATTTTGACGCTTGTAATGAAGTCCCTCCGGCTCCTAAAGAGTCCTCAACCAGTGAGGGCGCTGATCAGAAAATGAGCTCTTTTAAGGAA
GAAAAAGATATAAAGCCAATCATTAAAGATGAAAAAGGTCGGGTCGGCAGCGGTTCTGGTCGGAACCTGTGGGTCAGCGGGCTGTCCTCC
ACAACACGCGCTACGGATCTCAAGAACCTTTTCAGCAAGTATGGGAAGGTTGTCGGGGCCAAAGTGGTAACGAACGCCCGCAGCCCGGGG
GCTCGATGCTATGGATTCGTCACCATGTCGACATCTGACGAGGCGACCAAGTGCATCAGCCATCTCCACAGAACTGAGCTGCATGGACGA
ATGATCTCCGTAGAGAAGGCCAAAAATGAGCCTGCTGGGAAAAAGCTTTCCGACAGAAAAGAGTGCGAAGTGAAGAAGGAAAAATTATCG
AGTGTCGACAGACATCATTCTGTGGAGATCAAAATTGAAAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAG
CCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGA
GGAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCC
AAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAG
AGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAG
CGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGG
CTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAG
GAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAG
CGTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTAC
CAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGC
CACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGG
CTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATG
GACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGC
CGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGA
GTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCA
CTCGCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGT
AAATCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAA

>1463_1463_6_ACPP-SAFB2_ACPP_chr3_132036420_ENST00000475741_SAFB2_chr19_5616346_ENST00000252542_length(amino acids)=888AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLEDMEASLENLQNMGMMDMSVLDETEVANSSAPDFGEDGTDGL
LDSFCDSKEYVAAQLRQLPAQPPEHAVDGEGFKNTLETSSLNFKVTPDIEESLLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTS
SVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELA
EAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSFKEEKDIKPIIKDEKGRVGSGSGRNLWVSGLSSTTRATDLKN
LFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVE
IKIEKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSES
KEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVE
RERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRRE
GSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREH

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Fusion Gene PPI Analysis for ACPP-SAFB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSAFB2chr3:132036419chr19:5616345ENST00000252542221600_953113.0954.0SAFB1
TgeneSAFB2chr3:132036420chr19:5616346ENST00000252542221600_953113.0954.0SAFB1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACPP-SAFB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACPP-SAFB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource