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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD74-IQCE (FusionGDB2 ID:14633)

Fusion Gene Summary for CD74-IQCE

check button Fusion gene summary
Fusion gene informationFusion gene name: CD74-IQCE
Fusion gene ID: 14633
HgeneTgene
Gene symbol

CD74

IQCE

Gene ID

972

23288

Gene nameCD74 moleculeIQ motif containing E
SynonymsDHLAG|HLADG|II|Ia-GAMMA|p331700028P05Rik|PAPA7
Cytomap

5q33.1

7p22.3

Type of geneprotein-codingprotein-coding
DescriptionHLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated IQ domain-containing protein E
Modification date2020031320200313
UniProtAcc

P04233

Q6IPM2

Ensembl transtripts involved in fusion geneENST00000377795, ENST00000009530, 
ENST00000353334, ENST00000524315, 
ENST00000497572, ENST00000325979, 
ENST00000402050, ENST00000404984, 
ENST00000438376, 
Fusion gene scores* DoF score43 X 51 X 20=4386012 X 3 X 9=324
# samples 5912
** MAII scorelog2(59/43860*10)=-6.21604704731175
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD74 [Title/Abstract] AND IQCE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD74(149781200)-IQCE(2641075), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD74

GO:0001516

prostaglandin biosynthetic process

12782713

HgeneCD74

GO:0001934

positive regulation of protein phosphorylation

24942581

HgeneCD74

GO:0002792

negative regulation of peptide secretion

19849849

HgeneCD74

GO:0033674

positive regulation of kinase activity

24942581

HgeneCD74

GO:0043066

negative regulation of apoptotic process

12782713

HgeneCD74

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

24942581

HgeneCD74

GO:0043410

positive regulation of MAPK cascade

24942581

HgeneCD74

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

HgeneCD74

GO:0045657

positive regulation of monocyte differentiation

24942581

HgeneCD74

GO:0045893

positive regulation of transcription, DNA-templated

24942581

HgeneCD74

GO:0046598

positive regulation of viral entry into host cell

24942581

HgeneCD74

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

HgeneCD74

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821|24942581


check buttonFusion gene breakpoints across CD74 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IQCE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7854-01ACD74chr5

149781200

-IQCEchr7

2641075

+


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Fusion Gene ORF analysis for CD74-IQCE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000377795ENST00000497572CD74chr5

149781200

-IQCEchr7

2641075

+
In-frameENST00000377795ENST00000325979CD74chr5

149781200

-IQCEchr7

2641075

+
In-frameENST00000377795ENST00000402050CD74chr5

149781200

-IQCEchr7

2641075

+
In-frameENST00000377795ENST00000404984CD74chr5

149781200

-IQCEchr7

2641075

+
In-frameENST00000377795ENST00000438376CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000009530ENST00000325979CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000009530ENST00000402050CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000009530ENST00000404984CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000009530ENST00000438376CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000353334ENST00000325979CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000353334ENST00000402050CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000353334ENST00000404984CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000353334ENST00000438376CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000524315ENST00000325979CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000524315ENST00000402050CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000524315ENST00000404984CD74chr5

149781200

-IQCEchr7

2641075

+
intron-3CDSENST00000524315ENST00000438376CD74chr5

149781200

-IQCEchr7

2641075

+
intron-intronENST00000009530ENST00000497572CD74chr5

149781200

-IQCEchr7

2641075

+
intron-intronENST00000353334ENST00000497572CD74chr5

149781200

-IQCEchr7

2641075

+
intron-intronENST00000524315ENST00000497572CD74chr5

149781200

-IQCEchr7

2641075

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377795CD74chr5149781200-ENST00000404984IQCEchr72641075+618911385778189
ENST00000377795CD74chr5149781200-ENST00000402050IQCEchr72641075+6190113843183794174
ENST00000377795CD74chr5149781200-ENST00000438376IQCEchr72641075+1618113820502160
ENST00000377795CD74chr5149781200-ENST00000325979IQCEchr72641075+1618113820502160

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377795ENST00000404984CD74chr5149781200-IQCEchr72641075+0.702903870.2970961
ENST00000377795ENST00000402050CD74chr5149781200-IQCEchr72641075+0.75075050.24924953
ENST00000377795ENST00000438376CD74chr5149781200-IQCEchr72641075+0.095395910.9046041
ENST00000377795ENST00000325979CD74chr5149781200-IQCEchr72641075+0.095395910.9046041

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Fusion Genomic Features for CD74-IQCE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CD74chr5149781199-IQCEchr72641074+0.0002296480.99977034
CD74chr5149781199-IQCEchr72641074+0.0002296480.99977034

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CD74-IQCE


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:149781200/chr7:2641075)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD74

P04233

IQCE

Q6IPM2

FUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}.FUNCTION: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). {ECO:0000250|UniProtKB:Q6PCQ0, ECO:0000269|PubMed:28488682}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD74chr5:149781200chr7:2641075ENST00000377795-66210_271372280.6666666666667DomainThyroglobulin type-1
HgeneCD74chr5:149781200chr7:2641075ENST00000377795-661_46372280.6666666666667Topological domainCytoplasmic
HgeneCD74chr5:149781200chr7:2641075ENST00000377795-6673_296372280.6666666666667Topological domainExtracellular
HgeneCD74chr5:149781200chr7:2641075ENST00000377795-6647_72372280.6666666666667TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneIQCEchr5:149781200chr7:2641075ENST000003259791420534_539471631.0Compositional biasNote=Poly-Lys
TgeneIQCEchr5:149781200chr7:2641075ENST000004020501622534_539536696.0Compositional biasNote=Poly-Lys
TgeneIQCEchr5:149781200chr7:2641075ENST000004049841521534_539485645.0Compositional biasNote=Poly-Lys
TgeneIQCEchr5:149781200chr7:2641075ENST000004383761521534_539520680.0Compositional biasNote=Poly-Lys
TgeneIQCEchr5:149781200chr7:2641075ENST000003259791420542_571471631.0DomainIQ 1
TgeneIQCEchr5:149781200chr7:2641075ENST000003259791420601_630471631.0DomainIQ 2
TgeneIQCEchr5:149781200chr7:2641075ENST000004020501622542_571536696.0DomainIQ 1
TgeneIQCEchr5:149781200chr7:2641075ENST000004020501622601_630536696.0DomainIQ 2
TgeneIQCEchr5:149781200chr7:2641075ENST000004049841521542_571485645.0DomainIQ 1
TgeneIQCEchr5:149781200chr7:2641075ENST000004049841521601_630485645.0DomainIQ 2
TgeneIQCEchr5:149781200chr7:2641075ENST000004383761521542_571520680.0DomainIQ 1
TgeneIQCEchr5:149781200chr7:2641075ENST000004383761521601_630520680.0DomainIQ 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD74chr5:149781200chr7:2641075ENST00000009530-19210_2710297.0DomainThyroglobulin type-1
HgeneCD74chr5:149781200chr7:2641075ENST00000353334-18210_2710233.0DomainThyroglobulin type-1
HgeneCD74chr5:149781200chr7:2641075ENST00000009530-191_460297.0Topological domainCytoplasmic
HgeneCD74chr5:149781200chr7:2641075ENST00000009530-1973_2960297.0Topological domainExtracellular
HgeneCD74chr5:149781200chr7:2641075ENST00000353334-181_460233.0Topological domainCytoplasmic
HgeneCD74chr5:149781200chr7:2641075ENST00000353334-1873_2960233.0Topological domainExtracellular
HgeneCD74chr5:149781200chr7:2641075ENST00000009530-1947_720297.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCD74chr5:149781200chr7:2641075ENST00000353334-1847_720233.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneIQCEchr5:149781200chr7:2641075ENST000003259791420157_264471631.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr5:149781200chr7:2641075ENST000003259791420292_358471631.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr5:149781200chr7:2641075ENST000003259791420387_477471631.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr5:149781200chr7:2641075ENST000004020501622157_264536696.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr5:149781200chr7:2641075ENST000004020501622292_358536696.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr5:149781200chr7:2641075ENST000004020501622387_477536696.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr5:149781200chr7:2641075ENST000004049841521157_264485645.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr5:149781200chr7:2641075ENST000004049841521292_358485645.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr5:149781200chr7:2641075ENST000004049841521387_477485645.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr5:149781200chr7:2641075ENST000004383761521157_264520680.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr5:149781200chr7:2641075ENST000004383761521292_358520680.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr5:149781200chr7:2641075ENST000004383761521387_477520680.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for CD74-IQCE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14633_14633_1_CD74-IQCE_CD74_chr5_149781200_ENST00000377795_IQCE_chr7_2641075_ENST00000325979_length(transcript)=1618nt_BP=1138nt
CCGGGGGGTCAGGGTCCCAGATGCACAGGAGGAGAAGCAGGAGCTGTCGGGAAGATCAGAAGCCAGTCATGGATGACCAGCGCGACCTTA
TCTCCAACAATGAGCAACTGCCCATGCTGGGCCGGCGCCCTGGGGCCCCGGAGAGCAAGTGCAGCCGCGGAGCCCTGTACACAGGCTTTT
CCATCCTGGTGACTCTGCTCCTCGCTGGCCAGGCCACCACCGCCTACTTCCTGTACCAGCAGCAGGGCCGGCTGGACAAACTGACAGTCA
CCTCCCAGAACCTGCAGCTGGAGAACCTGCGCATGAAGCTTCCCAAGCCTCCCAAGCCTGTGAGCAAGATGCGCATGGCCACCCCGCTGC
TGATGCAGGCGCTGCCCATGGGAGCCCTGCCCCAGGGGCCCATGCAGAATGCCACCAAGTATGGCAACATGACAGAGGACCATGTGATGC
ACCTGCTCCAGAGTCACTGGAACTGGAGGACCCGTCTTCTGGGCTGGGTGTGACCAAGCAGGATCTGGGCCCAGTCCCCATGTGAGAGCA
GCAGAGGCGGTCTTCAACATCCTGCCAGCCCCACACAGCTACAGCTTTCTTGCTCCCTTCAGCCCCCAGCCCCTCCCCCATCTCCCACCC
TGTACCTCATCCCATGAGACCCTGGTGCCTGGCTCTTTCGTCACCCTTGGACAAGACAAACCAAGTCGGAACAGCAGATAACAATGCAGC
AAGGCCCTGCTGCCCAATCTCCATCTGTCAACAGGGGCGTGAGGTCCCAGGAAGTGGCCAAAAGCTAGACAGATCCCCGTTCCTGACATC
ACAGCAGCCTCCAACACAAGGCTCCAAGACCTAGGCTCATGGACGAGATGGGAAGGCACAGGGAGAAGGGATAACCCTACACCCAGACCC
CAGGCTGGACATGCTGACTGTCCTCTCCCCTCCAGCCTTTGGCCTTGGCTTTTCTAGCCTATTTACCTGCAGGCTGAGCCACTCTCTTCC
CTTTCCCCAGCATCACTCCCCAAGGAAGAGCCAATGTTTTCCACCCATAATCCTTTCTGCCGACCCCTAGTTCCCTCTGCTCAGCCAAGC
TTGTTATCAGCTTTCAGGGCCATGGTTCACATTAGAATAAAAGGTAGTAATTAGAACAAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGT
GGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGG
CCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCAT
CATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAG
ATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGC

>14633_14633_1_CD74-IQCE_CD74_chr5_149781200_ENST00000377795_IQCE_chr7_2641075_ENST00000325979_length(amino acids)=160AA_BP=
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL

--------------------------------------------------------------
>14633_14633_2_CD74-IQCE_CD74_chr5_149781200_ENST00000377795_IQCE_chr7_2641075_ENST00000402050_length(transcript)=6190nt_BP=1138nt
CCGGGGGGTCAGGGTCCCAGATGCACAGGAGGAGAAGCAGGAGCTGTCGGGAAGATCAGAAGCCAGTCATGGATGACCAGCGCGACCTTA
TCTCCAACAATGAGCAACTGCCCATGCTGGGCCGGCGCCCTGGGGCCCCGGAGAGCAAGTGCAGCCGCGGAGCCCTGTACACAGGCTTTT
CCATCCTGGTGACTCTGCTCCTCGCTGGCCAGGCCACCACCGCCTACTTCCTGTACCAGCAGCAGGGCCGGCTGGACAAACTGACAGTCA
CCTCCCAGAACCTGCAGCTGGAGAACCTGCGCATGAAGCTTCCCAAGCCTCCCAAGCCTGTGAGCAAGATGCGCATGGCCACCCCGCTGC
TGATGCAGGCGCTGCCCATGGGAGCCCTGCCCCAGGGGCCCATGCAGAATGCCACCAAGTATGGCAACATGACAGAGGACCATGTGATGC
ACCTGCTCCAGAGTCACTGGAACTGGAGGACCCGTCTTCTGGGCTGGGTGTGACCAAGCAGGATCTGGGCCCAGTCCCCATGTGAGAGCA
GCAGAGGCGGTCTTCAACATCCTGCCAGCCCCACACAGCTACAGCTTTCTTGCTCCCTTCAGCCCCCAGCCCCTCCCCCATCTCCCACCC
TGTACCTCATCCCATGAGACCCTGGTGCCTGGCTCTTTCGTCACCCTTGGACAAGACAAACCAAGTCGGAACAGCAGATAACAATGCAGC
AAGGCCCTGCTGCCCAATCTCCATCTGTCAACAGGGGCGTGAGGTCCCAGGAAGTGGCCAAAAGCTAGACAGATCCCCGTTCCTGACATC
ACAGCAGCCTCCAACACAAGGCTCCAAGACCTAGGCTCATGGACGAGATGGGAAGGCACAGGGAGAAGGGATAACCCTACACCCAGACCC
CAGGCTGGACATGCTGACTGTCCTCTCCCCTCCAGCCTTTGGCCTTGGCTTTTCTAGCCTATTTACCTGCAGGCTGAGCCACTCTCTTCC
CTTTCCCCAGCATCACTCCCCAAGGAAGAGCCAATGTTTTCCACCCATAATCCTTTCTGCCGACCCCTAGTTCCCTCTGCTCAGCCAAGC
TTGTTATCAGCTTTCAGGGCCATGGTTCACATTAGAATAAAAGGTAGTAATTAGAACAAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGT
GGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGG
CCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCAT
CATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAG
ATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGC
ACCTCTACCTGGGGATGACGTCAACTCCGATGATTCCGACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAGTTTAGGT
CCCCGTCACTGTCTCCACGCCGTGATGGCAGCGCTGCCGAGGACATAGGAACCACGACTGGAAAGATAATTTATCGTGTTAGGAGAAGAA
CGATGATACCTACTTAACACCTCAGCATCTGCGTCGTGTCTCTTTGTGCTTTTGTTTGTGGAAGGAGACCCAAATGCCTTTACTTTATTC
TCTGGGGAGGGCCAGCGGCTCGCATCCCCCTCATCTCCAGCTGCAGCTCGGATGGTGGATTTTCAGTGCCAACAGACACATCTGCCGTGA
ACTCGCAGATGCCAGGGAGCCCTGTAGTGACACGTTCTCTGACAGCACCTTGCCGCCTGCCCACGACCTTGACCGTGAGGAGCTGCTATC
CGCAACCAGCGCCGACACCATGCCCCCTCTTCCTGGTGACACCCTCAACAACCAGGATTTGCTCGATCTCAGCCCAGCAGGCCAGGCAGA
CACACCCCGCTGTGCCTTAGGAAGGTGTGAGACCGGCTTCCCCCATCCCCACAGCAAAACACGGCCTGTCCCAAGCCAGTGAGGAGCTAA
AGACACCCAGGTCCCCAAATGATCTTACTCCATGCCCCACCCGCTCACACCGTCCTTTCCCGTCACCCTTGCTATCCCCTGGAGCACTGC
CCTCCAGAGCTGCCCTTCCCAGGAAGGAATTTGGTTGGATTCTGTCACTGTGGAGACCAAGATTTTTTAAAATTCCCAATTACAAAAGCA
GCATCACACTTGCTTCTGAGAACAGCAGGGTGATGTCTGTTCCCAAGCTGGTGGCGGGAGCCTTAGCCTGTGTGGGGCCACCCGGGGAAG
AGGAGGAGAGGAGGGTGAGGAGGCAGGCTCGCCGTTCCAAGGGACAGCATAGGCTCGTGGTGGGGCGTGTTGCATCTGGTGTCTGGGACA
GTCCCCGTCACCCCATGTGTGCGGCCTCTGCACTCCCAAGCTCCATGGCTGGGCTGGGCTGGGCTGGGCTGGGCTGGGCCGGGCGTGCGG
AGCCTGTGGAGCCAGCAGCTGCAGAGGCCTAGGAGGGAGTTCCTGGGGGAAGCGCACAGTGTCCAGTGCCCATCTCTTGCTTGTGTGTGA
GATTAGCCCTTGCTGGGGCGTCAAGAGGAAGAGCCTTAGACCTGGGCGGGCCTTCAGGGGCATCTAGACCCCTGCACAGCCCAGGCCTGG
TGTCTGCATTTCCACAGCACCCCTGTGGGGACTCCTGCCGGGGCTGGCCGCTGTCTCAGGAGAGACCCAATGGTTAGAAAGCCCCTTTTT
ACACAGCTGACAGCTTCTCCCAAGGCTTCCGTCCACGGGGACAGGCTTAACCCCTGGGCGCCTTTTCTGCAGCATGGCGGCCTTCTGAGT
CACCTAAGCTGAGCCTGGGTCATTCTCTGTGGCGGTCAGAAGGCCGATGGCCCCAACACAGTGGCTTGTGAAAGGGAGAGAGGAGGCTCT
GCATGTCCACCTGCTCTATGGGAGGAGGACACAGGTGTCCCCAGCCCAGCCTGTTCTCTCCCAGTCACTCAGGGATGGGGCCACCCAAAG
TGCAGGACCCGCCCCACCCTGCGGTTCGAAGCCTGGCCCCTGTCTCCACTTAGCTTCTGTTTCTGCAGTGGGTGGAAGCGAGTCAGCGGG
GGGCCTGGCTTGTGTACGTGTTTTCCTTATTTGGTCTGTGGGTTGCCAAGTCCATTTTTTTTTCCACTGAACTGGCTGGTAACTTGATGG
ACTGTGTAACTGACACAGGCCCTCTTTAGACCCCTGCCTTCACCCCACCCGCCCGGGTCCACTCCCTGGGGCGCTGTCCCAAGCCATCCC
TGCTTGCCAGCTCAAAGCTTCAGGTCCTAGGAGCCAGTCCACCTCGAAAGCCCTGAGAAAGTGAGACACCTGCACATTCGCTGGGGGAGA
CCCTCCGTTCTCTTGTGGCAGCTGCTCCCACTTGTTAAACCAAGCTGTTTCTGCGGGACGTGCTCACTCTTGGGAACCAGTGGCCTAGAG
CTTTGGGTTACAGGCATGGAGAGGGCTTTCCTGCCTCAGGCTTGGAGGCCAATGTTCCATACATAAACCGCCATGTCCTCTGGTGCAGCT
GGGCTGCTCTTTTAAAAGCCAGCATCCATCTTGAAGCTCGCTGGGTAAATGGCAATGCATTCTCAAGCCAGTGTCTTCAGCTGATGCCCA
GTGTCCAGTGCTGGTCACCAGTCCCCTTTGCTGGGTACAGCCTGCCTGGCTGTTCTGTGGTCCTGGAACGCTGCAGTGTGGTTTTGTTCC
ATGGAGACAGTACCAAGCGGAGAGGCCTCCTTGCCCACGGCCCCAGGGCCTGGGGGCCAGGGGTTCTGGCCCTGCGGGGACTTAGGCAGG
AGGGGAAGAGAAGCCCATGGAGCCATGGGAGGGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGGCGGGGCGAGCTG
TGGGTGGGGCCTAGCCATGGGAGAGGTGAGCTGTGAATGGGGCTAGCTATGGGTGGGGTGAGCTGTGGACAGGGCCTAGCCATGGGAAAG
GTGAGCTGTGGGCGGGGCCTAGTCACGGGAGAGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGATGGGGCCTAGCC
ATGGGAGGGGTGAGCTGTGAGTGGGGCTGAGCCATGGGAGCAGCAAGCTGGTGGAGTGGGCTGGGCGGAGCTGTGGGGGCTGCTGGCAGG
GCCTAGGAAAGTAGACAACTCCCGGGGGAGACGAAGTAGAGAGTGAGTCCCCAAGAAAGGGACTCCTGCCCCAGCGTCAAGTGCCAAAGC
AGGCCCCATCTACCACTTCAGGGTCGACGTTGGTGGCAGGTGTTGTTCACGGTGTACTGATTGTCACTGCAACACCTCCACATCACCTTG
AACTTCAAGAACAGCAGCAAAGCTGTATCTGCTATCAGAGGCTGTTAGGTAGTCCAGCTTTAAAATAACACACTCTTTCTCTATCCCATG
CCCTTTAAACAAGCAGCCACAGGAGATGTCAGTCTCCAGGGCCTGGCCCCACTGTGTTGACAGCAGTCACGTCTGTTGAGCTGACACTGC
TGAGGCTGAAGCTGGCCCCGTGCAGGTGGCTGGTGAGCCACAGGTGCAGTACCCGGAGGTGTGCTCTCCCCTAGAGGCCTGTCCCCAACT
CCTCCCCTAGAGGCCTATTCCCGCTGCTCACAGACCTCAGCAGAGGCACCAGCTGGAGGGCTCCAGGGACATCCTTGGAGATACAGGAGG
CTTTCCTGGCACAGGGCACAGCTCTTAGGAGGCCTTTGTAGGACGCTGTCTCCCCAGCGTGTCCTGCTCATCCAGGATGGGGAGAAAGAG
GAGGAGGCCCCAGGCTCAGAAGCCAGGGACAGACTGCCGACGATTACCAAACTGAATCCAGGCAGTGCCATGACCCTGGGTGTCCCTTGG
TTCACATCACCCACCAGACAGCTGCGGAGAGAGTGCAGGGAGGGGCTGGGACCAAACAGGCCAGAAACCAGCAGAAAAGAGGCAGAAGTG
AGGTGGGTGTGCCTGGGGCACGAAGCCAGCGCCGGGGGGATTTCAGTGGAGCCTTACAGCCAGGCTCCGTGCGGACTGTGATGCCAGAGA
GGCGTGCAGCCTCTGGGCAAGTCGGGAGAGGGCTTGGGTGGTCCCCACAAGGCAGAAGAGGTGGAAGGGCCAGAGAAGACCACCAAGACC
ACCGTTCCCGCAGGCCTGGGGTGAGTGACCTGACTGAGACTAGCGGGCAGAGCCAAGCAGGGCTAAACTCCAACCCAGGGCCCGGTGTTG
GACAAAGTAGCTTTTTCTTTGCTCGTTTGTCTGTGTATTAAGAAGAGACTAAAATAGCCAAACGACGCTGGTCGCATGCGCTGGCTGTGG
TCTGTCTGCTGAATGTCTATTTTTGTCTCCTGACGAGACGTGAGGACCATGCCCTTGATCCCTCCGATGGACCAGAAACCCCCTTCCTTG
CAAAAAAAAGGCAATTGAATTAGGAAAAGATAGCCCAACCTAGCTCAGATCCACCAAGATAAGCACAGCAAAGCTTGGCTGCATTTTTGA
GGAATAAAAACCTGCAGAAAGCACCGATAACCTTCAAGATCTGAATGAGATTCTATTATAACCCGTCTAAACGATTGCAAAATTCCTCCT
TTGGTTTTGGAAGCAGCGTTTGCTCTCCCGTGGCTCGGATTCTCTGAGGACCAGGGAGTTGACACACAAACCCCGCCATGGGTCCGAGCC
AGCTATTTCTCAAGGCTCCCACCTCGCCAAGCTCCCAAGGGCCTGCTGGCAGTGCCTACGCTGTGCCAACTACCCTGTCTGGTACAGACC
ACGGCTGGGTAAGCACCCTTAAAAGCAACAGAAATGACGTCTGGAAGCTGAAATGTGAAACTGTCAAGATGGCTTAGGAGAGGAAGGAGT
GGACCCGCTGGTCTTTGGCATTTTGTATTTAGAATTATTCTAACTTTATACATAATGTATAGGCCGATCTTTTGGAAGGGATAAGGTTTT

>14633_14633_2_CD74-IQCE_CD74_chr5_149781200_ENST00000377795_IQCE_chr7_2641075_ENST00000402050_length(amino acids)=174AA_BP=
MPAAPTAPPSPLHQLAAPMAQPHSQLTPPMARPHPQLTPPMTRPRPQLTSPVTRPRPQLTFPMARPCPQLTPPIASPIHSSPLPWLGPTH

--------------------------------------------------------------
>14633_14633_3_CD74-IQCE_CD74_chr5_149781200_ENST00000377795_IQCE_chr7_2641075_ENST00000404984_length(transcript)=6189nt_BP=1138nt
CCGGGGGGTCAGGGTCCCAGATGCACAGGAGGAGAAGCAGGAGCTGTCGGGAAGATCAGAAGCCAGTCATGGATGACCAGCGCGACCTTA
TCTCCAACAATGAGCAACTGCCCATGCTGGGCCGGCGCCCTGGGGCCCCGGAGAGCAAGTGCAGCCGCGGAGCCCTGTACACAGGCTTTT
CCATCCTGGTGACTCTGCTCCTCGCTGGCCAGGCCACCACCGCCTACTTCCTGTACCAGCAGCAGGGCCGGCTGGACAAACTGACAGTCA
CCTCCCAGAACCTGCAGCTGGAGAACCTGCGCATGAAGCTTCCCAAGCCTCCCAAGCCTGTGAGCAAGATGCGCATGGCCACCCCGCTGC
TGATGCAGGCGCTGCCCATGGGAGCCCTGCCCCAGGGGCCCATGCAGAATGCCACCAAGTATGGCAACATGACAGAGGACCATGTGATGC
ACCTGCTCCAGAGTCACTGGAACTGGAGGACCCGTCTTCTGGGCTGGGTGTGACCAAGCAGGATCTGGGCCCAGTCCCCATGTGAGAGCA
GCAGAGGCGGTCTTCAACATCCTGCCAGCCCCACACAGCTACAGCTTTCTTGCTCCCTTCAGCCCCCAGCCCCTCCCCCATCTCCCACCC
TGTACCTCATCCCATGAGACCCTGGTGCCTGGCTCTTTCGTCACCCTTGGACAAGACAAACCAAGTCGGAACAGCAGATAACAATGCAGC
AAGGCCCTGCTGCCCAATCTCCATCTGTCAACAGGGGCGTGAGGTCCCAGGAAGTGGCCAAAAGCTAGACAGATCCCCGTTCCTGACATC
ACAGCAGCCTCCAACACAAGGCTCCAAGACCTAGGCTCATGGACGAGATGGGAAGGCACAGGGAGAAGGGATAACCCTACACCCAGACCC
CAGGCTGGACATGCTGACTGTCCTCTCCCCTCCAGCCTTTGGCCTTGGCTTTTCTAGCCTATTTACCTGCAGGCTGAGCCACTCTCTTCC
CTTTCCCCAGCATCACTCCCCAAGGAAGAGCCAATGTTTTCCACCCATAATCCTTTCTGCCGACCCCTAGTTCCCTCTGCTCAGCCAAGC
TTGTTATCAGCTTTCAGGGCCATGGTTCACATTAGAATAAAAGGTAGTAATTAGAACAAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGT
GGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGG
CCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCAT
CATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAG
ATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGC
ACCTCTACCTGGGGATGACGTCAACTCCGATGATTCCGACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAGTTTAGGT
CCCCGTCACTGTCTCCACGCCGTGATGGCAGCGCTGCCGAGGACATAGGAACCACGACTGGAAAGATAATTTATCGTGTTAGGAGAAGAA
CGATGATACCTACTTAACACCTCAGCATCTGCGTCGTGTCTCTTTGTGCTTTTGTTTGTGGAAGGAGACCCAAATGCCTTTACTTTATTC
TCTGGGGAGGGCCAGCGGCTCGCATCCCCCTCATCTCCAGCTGCAGCTCGGATGGTGGATTTTCAGTGCCAACAGACACATCTGCCGTGA
ACTCGCAGATGCCAGGGAGCCCTGTAGTGACACGTTCTCTGACAGCACCTTGCCGCCTGCCCACGACCTTGACCGTGAGGAGCTGCTATC
CGCAACCAGCGCCGACACCATGCCCCCTCTTCCTGGTGACACCCTCAACAACCAGGATTTGCTCGATCTCAGCCCAGCAGGCCAGGCAGA
CACACCCCGCTGTGCCTTAGGAAGGTGTGAGACCGGCTTCCCCCATCCCCACAGCAAAACACGGCCTGTCCCAAGCCAGTGAGGAGCTAA
AGACACCCAGGTCCCCAAATGATCTTACTCCATGCCCCACCCGCTCACACCGTCCTTTCCCGTCACCCTTGCTATCCCCTGGAGCACTGC
CCTCCAGAGCTGCCCTTCCCAGGAAGGAATTTGGTTGGATTCTGTCACTGTGGAGACCAAGATTTTTTAAAATTCCCAATTACAAAAGCA
GCATCACACTTGCTTCTGAGAACAGCAGGGTGATGTCTGTTCCCAAGCTGGTGGCGGGAGCCTTAGCCTGTGTGGGGCCACCCGGGGAAG
AGGAGGAGAGGAGGGTGAGGAGGCAGGCTCGCCGTTCCAAGGGACAGCATAGGCTCGTGGTGGGGCGTGTTGCATCTGGTGTCTGGGACA
GTCCCCGTCACCCCATGTGTGCGGCCTCTGCACTCCCAAGCTCCATGGCTGGGCTGGGCTGGGCTGGGCTGGGCTGGGCCGGGCGTGCGG
AGCCTGTGGAGCCAGCAGCTGCAGAGGCCTAGGAGGGAGTTCCTGGGGGAAGCGCACAGTGTCCAGTGCCCATCTCTTGCTTGTGTGTGA
GATTAGCCCTTGCTGGGGCGTCAAGAGGAAGAGCCTTAGACCTGGGCGGGCCTTCAGGGGCATCTAGACCCCTGCACAGCCCAGGCCTGG
TGTCTGCATTTCCACAGCACCCCTGTGGGGACTCCTGCCGGGGCTGGCCGCTGTCTCAGGAGAGACCCAATGGTTAGAAAGCCCCTTTTT
ACACAGCTGACAGCTTCTCCCAAGGCTTCCGTCCACGGGGACAGGCTTAACCCCTGGGCGCCTTTTCTGCAGCATGGCGGCCTTCTGAGT
CACCTAAGCTGAGCCTGGGTCATTCTCTGTGGCGGTCAGAAGGCCGATGGCCCCAACACAGTGGCTTGTGAAAGGGAGAGAGGAGGCTCT
GCATGTCCACCTGCTCTATGGGAGGAGGACACAGGTGTCCCCAGCCCAGCCTGTTCTCTCCCAGTCACTCAGGGATGGGGCCACCCAAAG
TGCAGGACCCGCCCCACCCTGCGGTTCGAAGCCTGGCCCCTGTCTCCACTTAGCTTCTGTTTCTGCAGTGGGTGGAAGCGAGTCAGCGGG
GGGCCTGGCTTGTGTACGTGTTTTCCTTATTTGGTCTGTGGGTTGCCAAGTCCATTTTTTTTTCCACTGAACTGGCTGGTAACTTGATGG
ACTGTGTAACTGACACAGGCCCTCTTTAGACCCCTGCCTTCACCCCACCCGCCCGGGTCCACTCCCTGGGGCGCTGTCCCAAGCCATCCC
TGCTTGCCAGCTCAAAGCTTCAGGTCCTAGGAGCCAGTCCACCTCGAAAGCCCTGAGAAAGTGAGACACCTGCACATTCGCTGGGGGAGA
CCCTCCGTTCTCTTGTGGCAGCTGCTCCCACTTGTTAAACCAAGCTGTTTCTGCGGGACGTGCTCACTCTTGGGAACCAGTGGCCTAGAG
CTTTGGGTTACAGGCATGGAGAGGGCTTTCCTGCCTCAGGCTTGGAGGCCAATGTTCCATACATAAACCGCCATGTCCTCTGGTGCAGCT
GGGCTGCTCTTTTAAAAGCCAGCATCCATCTTGAAGCTCGCTGGGTAAATGGCAATGCATTCTCAAGCCAGTGTCTTCAGCTGATGCCCA
GTGTCCAGTGCTGGTCACCAGTCCCCTTTGCTGGGTACAGCCTGCCTGGCTGTTCTGTGGTCCTGGAACGCTGCAGTGTGGTTTTGTTCC
ATGGAGACAGTACCAAGCGGAGAGGCCTCCTTGCCCACGGCCCCAGGGCCTGGGGGCCAGGGGTTCTGGCCCTGCGGGGACTTAGGCAGG
AGGGGAAGAGAAGCCCATGGAGCCATGGGAGGGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGGCGGGGCGAGCTG
TGGGTGGGGCCTAGCCATGGGAGAGGTGAGCTGTGAATGGGGCTAGCTATGGGTGGGGTGAGCTGTGGACAGGGCCTAGCCATGGGAAAG
GTGAGCTGTGGGCGGGGCCTAGTCACGGGAGAGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGATGGGGCCTAGCC
ATGGGAGGGGTGAGCTGTGAGTGGGGCTGAGCCATGGGAGCAGCAAGCTGGTGGAGTGGGCTGGGCGGAGCTGTGGGGGCTGCTGGCAGG
GCCTAGGAAAGTAGACAACTCCCGGGGGAGACGAAGTAGAGAGTGAGTCCCCAAGAAAGGGACTCCTGCCCCAGCGTCAAGTGCCAAAGC
AGGCCCCATCTACCACTTCAGGGTCGACGTTGGTGGCAGGTGTTGTTCACGGTGTACTGATTGTCACTGCAACACCTCCACATCACCTTG
AACTTCAAGAACAGCAGCAAAGCTGTATCTGCTATCAGAGGCTGTTAGGTAGTCCAGCTTTAAAATAACACACTCTTTCTCTATCCCATG
CCCTTTAAACAAGCAGCCACAGGAGATGTCAGTCTCCAGGGCCTGGCCCCACTGTGTTGACAGCAGTCACGTCTGTTGAGCTGACACTGC
TGAGGCTGAAGCTGGCCCCGTGCAGGTGGCTGGTGAGCCACAGGTGCAGTACCCGGAGGTGTGCTCTCCCCTAGAGGCCTGTCCCCAACT
CCTCCCCTAGAGGCCTATTCCCGCTGCTCACAGACCTCAGCAGAGGCACCAGCTGGAGGGCTCCAGGGACATCCTTGGAGATACAGGAGG
CTTTCCTGGCACAGGGCACAGCTCTTAGGAGGCCTTTGTAGGACGCTGTCTCCCCAGCGTGTCCTGCTCATCCAGGATGGGGAGAAAGAG
GAGGAGGCCCCAGGCTCAGAAGCCAGGGACAGACTGCCGACGATTACCAAACTGAATCCAGGCAGTGCCATGACCCTGGGTGTCCCTTGG
TTCACATCACCCACCAGACAGCTGCGGAGAGAGTGCAGGGAGGGGCTGGGACCAAACAGGCCAGAAACCAGCAGAAAAGAGGCAGAAGTG
AGGTGGGTGTGCCTGGGGCACGAAGCCAGCGCCGGGGGGATTTCAGTGGAGCCTTACAGCCAGGCTCCGTGCGGACTGTGATGCCAGAGA
GGCGTGCAGCCTCTGGGCAAGTCGGGAGAGGGCTTGGGTGGTCCCCACAAGGCAGAAGAGGTGGAAGGGCCAGAGAAGACCACCAAGACC
ACCGTTCCCGCAGGCCTGGGGTGAGTGACCTGACTGAGACTAGCGGGCAGAGCCAAGCAGGGCTAAACTCCAACCCAGGGCCCGGTGTTG
GACAAAGTAGCTTTTTCTTTGCTCGTTTGTCTGTGTATTAAGAAGAGACTAAAATAGCCAAACGACGCTGGTCGCATGCGCTGGCTGTGG
TCTGTCTGCTGAATGTCTATTTTTGTCTCCTGACGAGACGTGAGGACCATGCCCTTGATCCCTCCGATGGACCAGAAACCCCCTTCCTTG
CAAAAAAAAGGCAATTGAATTAGGAAAAGATAGCCCAACCTAGCTCAGATCCACCAAGATAAGCACAGCAAAGCTTGGCTGCATTTTTGA
GGAATAAAAACCTGCAGAAAGCACCGATAACCTTCAAGATCTGAATGAGATTCTATTATAACCCGTCTAAACGATTGCAAAATTCCTCCT
TTGGTTTTGGAAGCAGCGTTTGCTCTCCCGTGGCTCGGATTCTCTGAGGACCAGGGAGTTGACACACAAACCCCGCCATGGGTCCGAGCC
AGCTATTTCTCAAGGCTCCCACCTCGCCAAGCTCCCAAGGGCCTGCTGGCAGTGCCTACGCTGTGCCAACTACCCTGTCTGGTACAGACC
ACGGCTGGGTAAGCACCCTTAAAAGCAACAGAAATGACGTCTGGAAGCTGAAATGTGAAACTGTCAAGATGGCTTAGGAGAGGAAGGAGT
GGACCCGCTGGTCTTTGGCATTTTGTATTTAGAATTATTCTAACTTTATACATAATGTATAGGCCGATCTTTTGGAAGGGATAAGGTTTT

>14633_14633_3_CD74-IQCE_CD74_chr5_149781200_ENST00000377795_IQCE_chr7_2641075_ENST00000404984_length(amino acids)=189AA_BP=
MCGAGRMLKTASAALTWGLGPDPAWSHPAQKTGPPVPVTLEQVHHMVLCHVAILGGILHGPLGQGSHGQRLHQQRGGHAHLAHRLGRLGK
LHAQVLQLQVLGGDCQFVQPALLLVQEVGGGGLASEEQSHQDGKACVQGSAAALALRGPRAPAQHGQLLIVGDKVALVIHDWLLIFPTAP

--------------------------------------------------------------
>14633_14633_4_CD74-IQCE_CD74_chr5_149781200_ENST00000377795_IQCE_chr7_2641075_ENST00000438376_length(transcript)=1618nt_BP=1138nt
CCGGGGGGTCAGGGTCCCAGATGCACAGGAGGAGAAGCAGGAGCTGTCGGGAAGATCAGAAGCCAGTCATGGATGACCAGCGCGACCTTA
TCTCCAACAATGAGCAACTGCCCATGCTGGGCCGGCGCCCTGGGGCCCCGGAGAGCAAGTGCAGCCGCGGAGCCCTGTACACAGGCTTTT
CCATCCTGGTGACTCTGCTCCTCGCTGGCCAGGCCACCACCGCCTACTTCCTGTACCAGCAGCAGGGCCGGCTGGACAAACTGACAGTCA
CCTCCCAGAACCTGCAGCTGGAGAACCTGCGCATGAAGCTTCCCAAGCCTCCCAAGCCTGTGAGCAAGATGCGCATGGCCACCCCGCTGC
TGATGCAGGCGCTGCCCATGGGAGCCCTGCCCCAGGGGCCCATGCAGAATGCCACCAAGTATGGCAACATGACAGAGGACCATGTGATGC
ACCTGCTCCAGAGTCACTGGAACTGGAGGACCCGTCTTCTGGGCTGGGTGTGACCAAGCAGGATCTGGGCCCAGTCCCCATGTGAGAGCA
GCAGAGGCGGTCTTCAACATCCTGCCAGCCCCACACAGCTACAGCTTTCTTGCTCCCTTCAGCCCCCAGCCCCTCCCCCATCTCCCACCC
TGTACCTCATCCCATGAGACCCTGGTGCCTGGCTCTTTCGTCACCCTTGGACAAGACAAACCAAGTCGGAACAGCAGATAACAATGCAGC
AAGGCCCTGCTGCCCAATCTCCATCTGTCAACAGGGGCGTGAGGTCCCAGGAAGTGGCCAAAAGCTAGACAGATCCCCGTTCCTGACATC
ACAGCAGCCTCCAACACAAGGCTCCAAGACCTAGGCTCATGGACGAGATGGGAAGGCACAGGGAGAAGGGATAACCCTACACCCAGACCC
CAGGCTGGACATGCTGACTGTCCTCTCCCCTCCAGCCTTTGGCCTTGGCTTTTCTAGCCTATTTACCTGCAGGCTGAGCCACTCTCTTCC
CTTTCCCCAGCATCACTCCCCAAGGAAGAGCCAATGTTTTCCACCCATAATCCTTTCTGCCGACCCCTAGTTCCCTCTGCTCAGCCAAGC
TTGTTATCAGCTTTCAGGGCCATGGTTCACATTAGAATAAAAGGTAGTAATTAGAACAAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGT
GGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGG
CCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCAT
CATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAG
ATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGC

>14633_14633_4_CD74-IQCE_CD74_chr5_149781200_ENST00000377795_IQCE_chr7_2641075_ENST00000438376_length(amino acids)=160AA_BP=
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CD74-IQCE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD74-IQCE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD74-IQCE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource