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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CD81-ARMC3 (FusionGDB2 ID:14671)

Fusion Gene Summary for CD81-ARMC3

Fusion gene summary

Fusion gene information	Fusion gene name: CD81-ARMC3
	Fusion gene ID: 14671
		Hgene	Tgene
	Gene symbol	CD81	ARMC3
	Gene ID	975	219681
	Gene name	CD81 molecule	armadillo repeat containing 3
	Synonyms	CVID6\|S5.7\|TAPA1\|TSPAN28	CT81\|KU-CT-1
	Cytomap	11p15.5	10p12.2
	Type of gene	protein-coding	protein-coding
	Description	CD81 antigen26 kDa cell surface protein TAPA-1CD81 antigen (target of antiproliferative antibody 1)tetraspanin-28tspan-28	armadillo repeat-containing protein 3beta-catenin-like proteincancer/testis antigen 81
	Modification date	20200327	20200313
	UniProtAcc	P60033	Q5W041
	Ensembl transtripts involved in fusion gene	ENST00000263645, ENST00000381036, ENST00000481687, ENST00000492627, ENST00000524805, ENST00000526072,	ENST00000376528, ENST00000409049, ENST00000464017, ENST00000298032, ENST00000409983,
Fusion gene scores	* DoF score	18 X 10 X 10=1800	6 X 10 X 5=300
	# samples	20	9
	** MAII score	log2(20/1800*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/300*10)=-1.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CD81 [Title/Abstract] AND ARMC3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CD81(2398845)-ARMC3(23321790), # samples:3
Anticipated loss of major functional domain due to fusion event.	CD81-ARMC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CD81	GO:0000187	activation of MAPK activity	14676841
Hgene	CD81	GO:0008104	protein localization	14676841
Hgene	CD81	GO:0008284	positive regulation of cell proliferation	14676841
Hgene	CD81	GO:0030890	positive regulation of B cell proliferation	10400713
Hgene	CD81	GO:0034238	macrophage fusion	12796480
Hgene	CD81	GO:0035783	CD4-positive, alpha-beta T cell costimulation	22307619
Hgene	CD81	GO:0043128	positive regulation of 1-phosphatidylinositol 4-kinase activity	14676841
Hgene	CD81	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	14676841
Hgene	CD81	GO:0072659	protein localization to plasma membrane	27881302
Hgene	CD81	GO:1903911	positive regulation of receptor clustering	23858057
Hgene	CD81	GO:2000553	positive regulation of T-helper 2 cell cytokine production	8766544
Hgene	CD81	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	22307619
Hgene	CD81	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	8766544

Fusion gene breakpoints across CD81 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARMC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-NA-A5I1-01A	CD81	chr11	2398845	-	ARMC3	chr10	23321790	+
ChimerDB4	UCS	TCGA-NA-A5I1-01A	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
ChimerDB4	UCS	TCGA-NA-A5I1	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
ChimerDB4	UCS	TCGA-NA-A5I1	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
ChimerDB4	UCS	TCGA-NA-A5I1	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
ChimerDB4	UCS	TCGA-NA-A5I1	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+

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Fusion Gene ORF analysis for CD81-ARMC3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000263645	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
5CDS-intron	ENST00000263645	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
5CDS-intron	ENST00000263645	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
5CDS-intron	ENST00000263645	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
5CDS-intron	ENST00000263645	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
5CDS-intron	ENST00000263645	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
Frame-shift	ENST00000263645	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
Frame-shift	ENST00000263645	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
Frame-shift	ENST00000263645	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
In-frame	ENST00000263645	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000263645	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000263645	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000263645	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000263645	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000381036	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000381036	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000381036	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000381036	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000381036	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000381036	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000381036	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000381036	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000481687	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000481687	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000481687	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000481687	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000481687	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000481687	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000481687	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000481687	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000492627	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000492627	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000492627	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000492627	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000492627	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000492627	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000492627	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000492627	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000524805	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000524805	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000524805	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000524805	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000524805	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000524805	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000524805	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000524805	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000526072	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000526072	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000526072	ENST00000298032	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000526072	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000526072	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000526072	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-3CDS	ENST00000526072	ENST00000409983	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-3CDS	ENST00000526072	ENST00000409983	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000263645	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000263645	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000263645	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000263645	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000263645	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000263645	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000381036	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000381036	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000381036	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000381036	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000381036	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000381036	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000381036	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000381036	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000381036	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000381036	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000381036	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000381036	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000481687	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000481687	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000481687	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000481687	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000481687	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000481687	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000481687	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000481687	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000481687	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000481687	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000481687	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000481687	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000492627	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000492627	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000492627	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000492627	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000492627	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000492627	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000492627	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000492627	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000492627	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000492627	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000492627	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000492627	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000524805	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000524805	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000524805	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000524805	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000524805	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000524805	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000524805	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000524805	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000524805	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000524805	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000524805	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000524805	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000526072	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000526072	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000526072	ENST00000376528	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000526072	ENST00000376528	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000526072	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000526072	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000526072	ENST00000409049	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000526072	ENST00000409049	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000526072	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000526072	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23321790	+
intron-intron	ENST00000526072	ENST00000464017	CD81	chr11	2397587	+	ARMC3	chr10	23326199	+
intron-intron	ENST00000526072	ENST00000464017	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000263645

CD81

chr11

2398845

ENST00000298032

ARMC3

chr10

23326199

640

322

256

531

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000263645	ENST00000298032	CD81	chr11	2398845	+	ARMC3	chr10	23326199	+	0.08912017	0.9108798

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Fusion Genomic Features for CD81-ARMC3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CD81	chr11	2398845	+	ARMC3	chr10	23321789	+	1.10E-06	0.9999989
CD81	chr11	2398845	+	ARMC3	chr10	23321789	+	1.10E-06	0.9999989
CD81	chr11	2398845	+	ARMC3	chr10	23326198	+	4.07E-07	0.99999964
CD81	chr11	2398845	+	ARMC3	chr10	23321789	+	1.10E-06	0.9999989
CD81	chr11	2398845	+	ARMC3	chr10	23321789	+	1.10E-06	0.9999989
CD81	chr11	2398845	+	ARMC3	chr10	23326198	+	4.07E-07	0.99999964

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CD81-ARMC3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:2398845/chr10:23321790)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CD81 P60033	ARMC3 Q5W041
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells (PubMed:20237408, PubMed:27881302, PubMed:16449649). Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production (PubMed:15161911, PubMed:20237408). In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype (PubMed:22307619, PubMed:23858057, PubMed:8766544). Present in MHC class II compartments, may also play a role in antigen presentation (PubMed:8409388, PubMed:8766544). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction (By similarity). In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (PubMed:28871089). Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity). {ECO:0000250\|UniProtKB:P35762, ECO:0000269\|PubMed:12796480, ECO:0000269\|PubMed:15161911, ECO:0000269\|PubMed:16449649, ECO:0000269\|PubMed:20237408, ECO:0000269\|PubMed:22307619, ECO:0000269\|PubMed:23858057, ECO:0000269\|PubMed:27881302, ECO:0000269\|PubMed:28871089, ECO:0000269\|PubMed:8409388, ECO:0000269\|PubMed:8766544}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Association with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. {ECO:0000269\|PubMed:20375010, ECO:0000269\|PubMed:21516087, ECO:0000269\|PubMed:26116703}.; FUNCTION: (Microbial infection) Involved in SAMHD1-dependent restriction of HIV-1 replication. May support early replication of both R5- and X4-tropic HIV-1 viruses in T cells, likely via proteasome-dependent degradation of SAMHD1. {ECO:0000269\|PubMed:28871089}.; FUNCTION: (Microbial infection) Specifically required for Plasmodium falciparum infectivity of hepatocytes, controlling sporozoite entry into hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms. {ECO:0000269\|PubMed:12483205}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CD81

chr11:2398845

chr10:23326199

ENST00000263645

1_12

237.0

Topological domain

Cytoplasmic

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

627_633

689.0

Compositional bias

Note=Poly-Ser

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

695_698

689.0

Compositional bias

Note=Poly-Glu

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

140_179

689.0

Repeat

Note=ARM 4

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

15_54

689.0

Repeat

Note=ARM 1

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

181_220

689.0

Repeat

Note=ARM 5

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

222_262

689.0

Repeat

Note=ARM 6

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

264_304

689.0

Repeat

Note=ARM 7

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

306_345

689.0

Repeat

Note=ARM 8

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

346_385

689.0

Repeat

Note=ARM 9

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

388_427

689.0

Repeat

Note=ARM 10

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

429_468

689.0

Repeat

Note=ARM 11

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

470_509

689.0

Repeat

Note=ARM 12

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

57_96

689.0

Repeat

Note=ARM 2

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409049

98_138

689.0

Repeat

Note=ARM 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CD81

chr11:2398845

chr10:23326199

ENST00000263645

113_201

237.0

Topological domain

Extracellular

Hgene

CD81

chr11:2398845

chr10:23326199

ENST00000263645

225_236

237.0

Topological domain

Cytoplasmic

Hgene

CD81

chr11:2398845

chr10:23326199

ENST00000263645

34_63

237.0

Topological domain

Extracellular

Hgene

CD81

chr11:2398845

chr10:23326199

ENST00000263645

85_89

237.0

Topological domain

Cytoplasmic

Hgene

CD81

chr11:2398845

chr10:23326199

ENST00000263645

13_33

237.0

Transmembrane

Helical

Hgene

CD81

chr11:2398845

chr10:23326199

ENST00000263645

202_224

237.0

Transmembrane

Helical

Hgene

CD81

chr11:2398845

chr10:23326199

ENST00000263645

64_84

237.0

Transmembrane

Helical

Hgene

CD81

chr11:2398845

chr10:23326199

ENST00000263645

90_112

237.0

Transmembrane

Helical

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

627_633

803

873.0

Compositional bias

Note=Poly-Ser

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

695_698

803

873.0

Compositional bias

Note=Poly-Glu

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

627_633

796

866.0

Compositional bias

Note=Poly-Ser

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

695_698

796

866.0

Compositional bias

Note=Poly-Glu

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

140_179

803

873.0

Repeat

Note=ARM 4

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

15_54

803

873.0

Repeat

Note=ARM 1

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

181_220

803

873.0

Repeat

Note=ARM 5

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

222_262

803

873.0

Repeat

Note=ARM 6

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

264_304

803

873.0

Repeat

Note=ARM 7

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

306_345

803

873.0

Repeat

Note=ARM 8

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

346_385

803

873.0

Repeat

Note=ARM 9

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

388_427

803

873.0

Repeat

Note=ARM 10

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

429_468

803

873.0

Repeat

Note=ARM 11

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

470_509

803

873.0

Repeat

Note=ARM 12

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

57_96

803

873.0

Repeat

Note=ARM 2

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000298032

98_138

803

873.0

Repeat

Note=ARM 3

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

140_179

796

866.0

Repeat

Note=ARM 4

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

15_54

796

866.0

Repeat

Note=ARM 1

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

181_220

796

866.0

Repeat

Note=ARM 5

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

222_262

796

866.0

Repeat

Note=ARM 6

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

264_304

796

866.0

Repeat

Note=ARM 7

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

306_345

796

866.0

Repeat

Note=ARM 8

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

346_385

796

866.0

Repeat

Note=ARM 9

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

388_427

796

866.0

Repeat

Note=ARM 10

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

429_468

796

866.0

Repeat

Note=ARM 11

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

470_509

796

866.0

Repeat

Note=ARM 12

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

57_96

796

866.0

Repeat

Note=ARM 2

Tgene

ARMC3

chr11:2398845

chr10:23326199

ENST00000409983

98_138

796

866.0

Repeat

Note=ARM 3

Top

Fusion Gene Sequence for CD81-ARMC3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>14671_14671_1_CD81-ARMC3_CD81_chr11_2398845_ENST00000263645_ARMC3_chr10_23326199_ENST00000298032_length(transcript)=640nt_BP=322nt
AGCGAGGCGCGCGCCCGGCCAGAGAGCGAGCGCGCAACGGCGGCGACGGCGGCGACCCCACCGCGCATCCTGCCAGGCCTCCGGCGCCCA
GCGCCCCACGCGCCCCCGCGCCCCCGCGCCCCCGCGCCCCTTTCTTCGCGCCCCCGCCCCTCGGCCCGCCAGGCCCCCTTGCCGGCCACC
CGCCAGGCCCCGCGCCGGCCCGCCCGCCGCCCAGGACCGGCCCGCGCCCCGCAGGCCGCCCGCCGCCCGCGCCGCCATGGGAGTGGAGGG
CTGCACCAAGTGCATCAAGTACCTGCTCTTCGTCTTCAATTTCGTCTTCTGGGCTCTGGCTGATAGAATTGGCATTGGTTGCTCCCTAGT
TCGCGGAGAGTACGGTAGAGCGTGGAATGAAGTCATGCTGCAGAATGACTCTCGGAAGGGAGTGATTGGGGGCCTCCCCGCTCCTGAGAT
GTACGTGATTGACCTCATGTTCCATCCAGGTGGACTGATGAAGTTGAGAAGTCGAGAGGCTGATCTTTACAGATTCATTTAAGCCATCAG
ACGAACACAAGAGAGGCTCAAACAAGAAATTCACTGTGTACACTCTCTAAGACATTCTCCAAATTGATTTTATCTCTTTAAATAAAAACT

>14671_14671_1_CD81-ARMC3_CD81_chr11_2398845_ENST00000263645_ARMC3_chr10_23326199_ENST00000298032_length(amino acids)=91AA_BP=22
MGVEGCTKCIKYLLFVFNFVFWALADRIGIGCSLVRGEYGRAWNEVMLQNDSRKGVIGGLPAPEMYVIDLMFHPGGLMKLRSREADLYRF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CD81-ARMC3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CD81-ARMC3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CD81-ARMC3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source