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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDC23-CYB5B (FusionGDB2 ID:14788)

Fusion Gene Summary for CDC23-CYB5B

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC23-CYB5B
Fusion gene ID: 14788
HgeneTgene
Gene symbol

CDC23

CYB5B

Gene ID

8697

80777

Gene namecell division cycle 23cytochrome b5 type B
SynonymsANAPC8|APC8|CUT23CYB5-M|CYPB5M|OMB5
Cytomap

5q31.2

16q22.1

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle protein 23 homologanaphase-promoting complex subunit 8cell division cycle 23 homologcyclosome subunit 8cytochrome b5 type Bcytochrome b5 outer mitochondrial membrane isoformcytochrome b5 type B (outer mitochondrial membrane)outer mitochondrial membrane cytochrome b5type 2 cyt-b5
Modification date2020031320200313
UniProtAcc

Q9UJX2

O43169

Ensembl transtripts involved in fusion geneENST00000394886, ENST00000394884, 
ENST00000505120, 		ENST00000561792, 
ENST00000512062, ENST00000515314, 
ENST00000307892, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 8 X 9=576
# samples 213
** MAII scorelog2(2/8*10)=1.32192809488736log2(13/576*10)=-2.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDC23 [Title/Abstract] AND CYB5B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDC23(137542235)-CYB5B(69496332), # samples:1
Anticipated loss of major functional domain due to fusion event.CDC23-CYB5B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CDC23-CYB5B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC23

GO:0000278

mitotic cell cycle

14657031

HgeneCDC23

GO:0007080

mitotic metaphase plate congression

14657031

HgeneCDC23

GO:0030071

regulation of mitotic metaphase/anaphase transition

9790767

HgeneCDC23

GO:0070979

protein K11-linked ubiquitination

18485873


check buttonFusion gene breakpoints across CDC23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CYB5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A4P3CDC23chr5

137542235

-CYB5Bchr16

69496332

+


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Fusion Gene ORF analysis for CDC23-CYB5B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000394886ENST00000561792CDC23chr5

137542235

-CYB5Bchr16

69496332

+
Frame-shiftENST00000394886ENST00000512062CDC23chr5

137542235

-CYB5Bchr16

69496332

+
Frame-shiftENST00000394886ENST00000515314CDC23chr5

137542235

-CYB5Bchr16

69496332

+
In-frameENST00000394886ENST00000307892CDC23chr5

137542235

-CYB5Bchr16

69496332

+
intron-3CDSENST00000394884ENST00000307892CDC23chr5

137542235

-CYB5Bchr16

69496332

+
intron-3CDSENST00000394884ENST00000512062CDC23chr5

137542235

-CYB5Bchr16

69496332

+
intron-3CDSENST00000394884ENST00000515314CDC23chr5

137542235

-CYB5Bchr16

69496332

+
intron-3CDSENST00000505120ENST00000307892CDC23chr5

137542235

-CYB5Bchr16

69496332

+
intron-3CDSENST00000505120ENST00000512062CDC23chr5

137542235

-CYB5Bchr16

69496332

+
intron-3CDSENST00000505120ENST00000515314CDC23chr5

137542235

-CYB5Bchr16

69496332

+
intron-intronENST00000394884ENST00000561792CDC23chr5

137542235

-CYB5Bchr16

69496332

+
intron-intronENST00000505120ENST00000561792CDC23chr5

137542235

-CYB5Bchr16

69496332

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394886CDC23chr5137542235-ENST00000307892CYB5Bchr1669496332+42384034507167

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394886ENST00000307892CDC23chr5137542235-CYB5Bchr1669496332+0.0133900840.9866099

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Fusion Genomic Features for CDC23-CYB5B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDC23chr5137542235-CYB5Bchr1669496332+1.22E-050.9999877
CDC23chr5137542235-CYB5Bchr1669496332+1.22E-050.9999877

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDC23-CYB5B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:137542235/chr16:69496332)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC23

Q9UJX2

CYB5B

O43169

FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.FUNCTION: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-31627_63124598.0RepeatNote=TPR 1
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-31673_112124598.0RepeatNote=TPR 2
TgeneCYB5Bchr5:137542235chr16:69496332ENST0000051206235123_140116147.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-13114_1440152.0RepeatNote=TPR 3
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-13169_2000152.0RepeatNote=TPR 4
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-13229_2590152.0RepeatNote=TPR 5
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-13263_2930152.0RepeatNote=TPR 6
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-1327_630152.0RepeatNote=TPR 1
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-13297_3270152.0RepeatNote=TPR 7
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-13331_3610152.0RepeatNote=TPR 8
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-13366_3950152.0RepeatNote=TPR 9
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-13400_4320152.0RepeatNote=TPR 10
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-13433_4660152.0RepeatNote=TPR 11
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-13468_5000152.0RepeatNote=TPR 12
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-13504_5400152.0RepeatNote=TPR 13
HgeneCDC23chr5:137542235chr16:69496332ENST00000394884-1373_1120152.0RepeatNote=TPR 2
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-316114_144124598.0RepeatNote=TPR 3
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-316169_200124598.0RepeatNote=TPR 4
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-316229_259124598.0RepeatNote=TPR 5
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-316263_293124598.0RepeatNote=TPR 6
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-316297_327124598.0RepeatNote=TPR 7
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-316331_361124598.0RepeatNote=TPR 8
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-316366_395124598.0RepeatNote=TPR 9
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-316400_432124598.0RepeatNote=TPR 10
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-316433_466124598.0RepeatNote=TPR 11
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-316468_500124598.0RepeatNote=TPR 12
HgeneCDC23chr5:137542235chr16:69496332ENST00000394886-316504_540124598.0RepeatNote=TPR 13
TgeneCYB5Bchr5:137542235chr16:69496332ENST000005120623524_100116147.0DomainCytochrome b5 heme-binding


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Fusion Gene Sequence for CDC23-CYB5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14788_14788_1_CDC23-CYB5B_CDC23_chr5_137542235_ENST00000394886_CYB5B_chr16_69496332_ENST00000307892_length(transcript)=4238nt_BP=403nt
ATGATTGGCTGGAGTGGCCCGAGTCGGGAAAATGGCTGCGAGTACCTCCATGGTCCCGGTGGCTGTGACGGCGGCAGTGGCGCCTGTCCT
GTCCATAAACAGCGATTTCTCAGATTTGCGGGAAATTAAAAAGCAACTGCTGCTTATTGCGGGCCTTACCCGGGAGCGGGGCCTACTACA
CAGTAGCAAATGGTCGGCGGAGTTGGCTTTCTCTCTCCCTGCATTGCCTCTGGCCGAGCTGCAACCGCCTCCGCCTATTACAGAGGAAGA
TGCCCAGGATATGGATGCCTATACCCTGGCCAAGGCCTACTTTGACGTTAAAGAGTATGATCGGGCAGCACATTTCCTGCATGGCTGCAA
TAGCAAGAAAGCCTATTTTCTGTATATGTATTCCAGATATCTGTTGCTGGGCATATTGGATTTTACCCATCATAGGCGCTGTTCTCTTAG
GTTTCCTGTACCGCTACTACACATCGGAAAGCAAATCCTCCTGAGGAGGCCTTGCTGAAGTTAGAAAGTGCATCCACTTTGGGGCGAAAA
CTAGAGACTTGCTTGGGGGCTGCAGAAGTGCCCTCTCCTCGAATCCTGCCAGTTGCATTCTTCCCCCTTGGAGCCAAGACGATTGGCCAG
ACATCACCTCAGATCTGAGACCAGCGTCTTCCATCTCTCAGAGCCTTACTCCCAAAGTACCTGCTCACTGTTCCGTGTTGAACAATTGCC
GGTGTTTCCTCTCTTCACTGGTTTCCATGAGTACCCTTATATTTCACAACTTTCTGTTCATAAGTTATAGTGACATTGCTCTTTGGTAAA
AATGCCTGCTTTCCAATACTTTGATTGCATATTAGACATTCTTAACAGGGCGGCAGTCTAGTGTTGAAAGTTTTATTTTTCCATTTTTCT
TTTAAGTAAATTTTTTTTAAAAAATTCTGATTTAGGGCTAGGTGTGGTGGCTCAGGCCTGTAATCCTGGCACTTTGGGAGGCCAAGGTGG
GAAGATCGCTTGAGGCCAAGAGTTCAAGACCAGCCTGGGCAACATAGCGAGACCCCTATCTGTATTAAAAAAAAATCTGATTTAATTCTT
TTATTTATCATAAGGGGTTTAATTCCTGAAGTAAAGGTTTGCACCTATTAAACTTAAAACTGCCAAATGATTTTTGTTCTTTTATGTGCG
TGATAAAAATACAAAGAATGGTGTGGCCACCTCCTCCCTTTCAAGCTAGGGCAGCAGGTAGCTCTTCCCAGCCCCTGAGCCCAGCCCCTT
CCCAAGTGGTGCCGGACAAAAAACTACATGGCCCTTTCGTGTCTTGGGGGTGGAAAGGTAGGGATGAATTGGGGTGATAGAACCCTGGTG
AATTCAGAGTAATCTTTCTTTAGAAAACTGGTGTTTTCTAAAGAAACAGGATAGGAGTTTAGAGAAGGCACCAAAGCTTTCACTTTGGTT
TGGCACCAGTTTCTAACCATCTGTTTTTTCTACCCTAGCTATCTTTTATTGGTAAAATATAAATGTATAATTATGTTTGTAGAGCTTTAC
CAAGGAGTTTCCCTCCTTTTTTGTTTGTTGATTAGCAAATTTTTGATTCTCCATTTTCCAAAAGTAAGAGACTCCAGCATGGCCTTCTGT
TTGCCCCGCAGTAAAGTAACTTCCATATAAAATGGTATTTGAAAGTGAGAGTTCATGACAACAGACCGTTTTCCATTTCATCTGTATTTT
ATCTCCGTGACTCCAACTTGTGGGTTTGTTCTGTTTTTCCATGAGAATAAAATACTGGCGGTTTTTTTCTCAGATGTGTGTTCATTGAGA
AGTAGGTTACTAGAATTATGTTACTGTGTCTTATTGGTTCAATGATGATTTCTCTGGCATATTAGACTTTTATTTTTTCCCCCATGGAAG
CACTTGAGGAAATAAATAGTACACTGGCTGTTTTCTGCCAGCAACTGTGGTGATTTTTCTCCCTGTCCTTTGAGAATTGCTAGTCTGCTT
CTGAGCCATTGTCATATCCAGCAGGGAGCAGCTTGGTTCAAGAAGGACCATAGAGGCTGCTCAGCATCTCCTCCCTCCCTCCCAGCTTGC
CAGGGATTTGATGAGACAGGAAACTGCCCAGCAAACCAGGGACTGCCCATGTAAACTATTTAAGAAAAAGTTCAACCCAGGTCTTGTATC
CTGTGATTTAGCAGTTGAATGAATACAGAATTCATCAAAATAATATTAACCTTGTACTTGCACACTTGGATATATTTGGGAGTAATTTTA
GGAGATTTCTGGCTGACTTTTATTATCAGGGATATGGGTTTAGTAAAGCTTTTATCTTTAGAAAAATGTTTGTATGCATTATAAGATGCT
ACTTTTAAGACAATATTGAAAAAAACTTTGGTTATTATTTAACAAAAGTGGTATGACTTGATGCTTCTCTATTTAAAGGCAAGGAAGGAT
TGGTATATGATTGCCTGTAATAAATAAATTGCGTGATTATTGGAGTACATTGGGGTAAAAGTAAAGAACAGAGGAGTATTGAGGAGCTTG
AAAGGGAACATTCAAACTAAAGCCAAGCCTGAAGATAACTTGAATCAGTTGTAAAAGTGTGTTGGCAATGTCCGAAATTGAATGAAAAAC
ATCTGGCTTATAAGAAATGTTAAAGAACTACCATCTTAAGTAAAATTGGTGTTTTTGTTATTTTTAAGGTAAATGCCAATGCAAAAGGTA
TGTTTTTCTACTTCACATTGGTTTTCTTTTCCTGTTTACATCTGCACTTGTTTTTTGCTGAGAGCCAGAGGAAAAGATAATTAGACTTTG
TCTCTTCCACCCATGAAATCCCCCAGTACCCAGGGCTTCTTCTGAACTACTGCCGATGTGATGTCACTTTGTATCTGGAAAATCACTTTG
GGGTCCATTTACTGTTATTTTGTTGCCTACAAAAACAGCCAGGTGAAAGCTAAATCTTGTGTGAGAGTTTGCAGAGGTTTTTCTATACAA
TAAAGTAGTATAGCACACTAGCCAAATCCATCCAAAAGGACCTTTTTTTTAGGAAGTAGACTTGAATTCACAAAACAGTCTTGACATGGG
TAGCTGGTGAAAAACCCTCTGGAGAGCAAGTGGAGCCAGTCCCCATTGGCTGACAGTGCCACCTGGAGCTGGTCTCTGGGGTGTTCGGTT
GTTTATTCCTGAGGAAGACTAGCTGCTGCTGCTGCTGCTGCTGCAAACTGTACTGTACACATCATGGCTGCTGGACACGAAGGAGGAGGT
GAGAGAAGTTTCATGCTACCGAAATAGAGGGTGTTGGTACCACTGCCCCTGGCCTGAGAGCCAGGGTTTAAACCTGCCTCAGTAGAGTCT
AGTTTGAAATGACACCAAAATTCCTCAGCCCCTACTCAGCAATTGGTTTTGGTTTCCAAATGACTTCTGCATTTGTAAAGATAACAGAGT
GGTGGGGTCAAAGTTTATCTTGTGTTTAGATCTCTTCAAGACTGCTTAAGCAAAAACAAAAATCCCTTGGAACCTATCGTTTGAGCCTGT
AAAGTTGTTTTAGCAGTTGTCATAAATGCATATGTTGTGAAATCAGAACACTGTCGAGTTTATACTCATTTAGCTGCAATGTGGGACAAT
GAAAAATGCTTTACAGGCCTGGAGTATCATTACTTATGGTATCTCCTGCTTTAAAATCTCAAGCGATATCTATCTGGTTAAATTCCATTT
TAGGAGATTGAGATGCAGAACGTTAATGTTCATTACCTCCTCCTACCCCAAGAGAAATGGATTCAGACATGTCTTGTCTCAACAAGAAAT
TGATTTTTTTTTAAACTATCTTATTCTGTTGCCAAATATCACAGAAGTAATGAGGAGTTTAGTTACATTTGGCTGTTGTGCTCTGAAAGA
GCCAGGTTTGGAATTTGTGGGGGTGATCTAGGAAGAAGGTTCCAAAGAAGCAGAGGCATTTGTCAAGTTACCTACCCTATATCCAGCATC
CTCCTCATGAGCTTCAGTAGCTGCTCTTTGCCCACGCTTGTATCCTACGTTTGCTATTTGGGCAAACCATTACTTCAGTTATTTAACTTC
CCTTTTTTTTTAACTTCACCTTTGACTATGAACAAGTAACGGTAACATTCCTTTTGTGTATTCAATAATGCAGTTAGTTTACCTTTTTCA
GAATATTTTGAACAAAGATCTTTGTCTCTTTCTGCTGGAATGCGCACACAGTGAACGTTTGTTAGAACTACACACAATAAAGACACTGTT

>14788_14788_1_CDC23-CYB5B_CDC23_chr5_137542235_ENST00000394886_CYB5B_chr16_69496332_ENST00000307892_length(amino acids)=167AA_BP=133
MAGVARVGKMAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLAELQPPPPITEEDA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDC23-CYB5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDC23-CYB5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDC23-CYB5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource