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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACSBG2-L2HGDH (FusionGDB2 ID:1480)

Fusion Gene Summary for ACSBG2-L2HGDH

check button Fusion gene summary
Fusion gene informationFusion gene name: ACSBG2-L2HGDH
Fusion gene ID: 1480
HgeneTgene
Gene symbol

ACSBG2

L2HGDH

Gene ID

81616

79944

Gene nameacyl-CoA synthetase bubblegum family member 2L-2-hydroxyglutarate dehydrogenase
SynonymsBGR|BRGL|PRTD-NY3|PRTDNY3C14orf160|L2HGA
Cytomap

19p13.3

14q21.3

Type of geneprotein-codingprotein-coding
Descriptionlong-chain-fatty-acid--CoA ligase ACSBG2arachidonate--CoA ligase ACSBG2bubblegum-related proteintesticular tissue protein Li 8L-2-hydroxyglutarate dehydrogenase, mitochondrial2-hydroxyglutarate dehydrogenaseL-alpha-hydroxyglutarate dehydrogenasealpha-hydroxyglutarate oxidoreductasealpha-ketoglutarate reductaseduranin
Modification date2020032020200313
UniProtAcc

Q5FVE4

Q9H9P8

Ensembl transtripts involved in fusion geneENST00000252669, ENST00000586696, 
ENST00000588304, ENST00000588485, 
ENST00000591403, ENST00000591741, 
ENST00000261699, ENST00000267436, 
ENST00000421284, ENST00000555423, 
ENST00000555610, ENST00000556393, 
Fusion gene scores* DoF score2 X 2 X 1=411 X 9 X 6=594
# samples 213
** MAII scorelog2(2/4*10)=2.32192809488736log2(13/594*10)=-2.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACSBG2 [Title/Abstract] AND L2HGDH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACSBG2(6144142)-L2HGDH(50777783), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACSBG2

GO:0006631

fatty acid metabolic process

16371355|16762313

TgeneL2HGDH

GO:0044267

cellular protein metabolic process

16005139


check buttonFusion gene breakpoints across ACSBG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across L2HGDH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG055224ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+


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Fusion Gene ORF analysis for ACSBG2-L2HGDH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000252669ENST00000261699ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000252669ENST00000267436ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000252669ENST00000421284ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000252669ENST00000555423ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000252669ENST00000555610ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000252669ENST00000556393ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000586696ENST00000261699ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000586696ENST00000267436ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000586696ENST00000421284ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000586696ENST00000555423ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000586696ENST00000555610ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000586696ENST00000556393ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588304ENST00000261699ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588304ENST00000267436ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588304ENST00000421284ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588304ENST00000555423ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588304ENST00000555610ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588304ENST00000556393ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588485ENST00000261699ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588485ENST00000267436ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588485ENST00000421284ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588485ENST00000555423ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588485ENST00000555610ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000588485ENST00000556393ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591403ENST00000261699ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591403ENST00000267436ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591403ENST00000421284ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591403ENST00000555423ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591403ENST00000555610ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591403ENST00000556393ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591741ENST00000261699ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591741ENST00000267436ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591741ENST00000421284ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591741ENST00000555423ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591741ENST00000555610ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+
intron-intronENST00000591741ENST00000556393ACSBG2chr19

6144142

+L2HGDHchr14

50777783

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ACSBG2-L2HGDH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACSBG2-L2HGDH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:6144142/:50777783)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACSBG2

Q5FVE4

L2HGDH

Q9H9P8

FUNCTION: Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:16371355, PubMed:16762313). Has increased ability to activate oleic and linoleic acid (PubMed:16371355). May play a role in spermatogenesis (PubMed:15685348). {ECO:0000269|PubMed:15685348, ECO:0000269|PubMed:16371355, ECO:0000269|PubMed:16762313}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ACSBG2-L2HGDH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACSBG2-L2HGDH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACSBG2-L2HGDH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACSBG2-L2HGDH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource