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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACSF2-HSF5 (FusionGDB2 ID:1485)

Fusion Gene Summary for ACSF2-HSF5

check button Fusion gene summary
Fusion gene informationFusion gene name: ACSF2-HSF5
Fusion gene ID: 1485
HgeneTgene
Gene symbol

ACSF2

HSF5

Gene ID

80221

124535

Gene nameacyl-CoA synthetase family member 2heat shock transcription factor 5
SynonymsACSMW|AVYV493HSF 5|HSTF 5
Cytomap

17q21.33

17q22

Type of geneprotein-codingprotein-coding
Descriptionmedium-chain acyl-CoA ligase ACSF2, mitochondrialPPARG binding, long chain fatty acid acyl Co-A ligase likeacyl-CoA synthetase family member 2, mitochondrialheat shock factor protein 5heat shock transcription factor family member 5
Modification date2020031320200313
UniProtAcc

Q96CM8

Q4G112

Ensembl transtripts involved in fusion geneENST00000541920, ENST00000300441, 
ENST00000427954, ENST00000502667, 
ENST00000504392, ENST00000506085, 
ENST00000323777, 
Fusion gene scores* DoF score6 X 4 X 4=967 X 4 X 6=168
# samples 68
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACSF2 [Title/Abstract] AND HSF5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACSF2(48503750)-HSF5(56499791), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACSF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HSF5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8295-01AACSF2chr17

48503750

+HSF5chr17

56499791

-


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Fusion Gene ORF analysis for ACSF2-HSF5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000541920ENST00000323777ACSF2chr17

48503750

+HSF5chr17

56499791

-
In-frameENST00000300441ENST00000323777ACSF2chr17

48503750

+HSF5chr17

56499791

-
In-frameENST00000427954ENST00000323777ACSF2chr17

48503750

+HSF5chr17

56499791

-
In-frameENST00000502667ENST00000323777ACSF2chr17

48503750

+HSF5chr17

56499791

-
In-frameENST00000504392ENST00000323777ACSF2chr17

48503750

+HSF5chr17

56499791

-
intron-3CDSENST00000506085ENST00000323777ACSF2chr17

48503750

+HSF5chr17

56499791

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000300441ACSF2chr1748503750+ENST00000323777HSF5chr1756499791-24962323531392
ENST00000504392ACSF2chr1748503750+ENST00000323777HSF5chr1756499791-24361724425369
ENST00000427954ACSF2chr1748503750+ENST00000323777HSF5chr1756499791-24351714325269
ENST00000502667ACSF2chr1748503750+ENST00000323777HSF5chr1756499791-24021381021969

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000300441ENST00000323777ACSF2chr1748503750+HSF5chr1756499791-0.80723460.19276544
ENST00000504392ENST00000323777ACSF2chr1748503750+HSF5chr1756499791-0.898062350.10193765
ENST00000427954ENST00000323777ACSF2chr1748503750+HSF5chr1756499791-0.87859060.12140946
ENST00000502667ENST00000323777ACSF2chr1748503750+HSF5chr1756499791-0.71031390.28968605

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Fusion Genomic Features for ACSF2-HSF5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACSF2-HSF5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:48503750/chr17:56499791)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACSF2

Q96CM8

HSF5

Q4G112

FUNCTION: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044). Has some preference toward medium-chain substrates (PubMed:17762044). Plays a role in adipocyte differentiation (PubMed:16380219). {ECO:0000269|PubMed:16380219, ECO:0000269|PubMed:17762044}.FUNCTION: May act as a transcriptional factor. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACSF2chr17:48503750chr17:56499791ENST00000300441+116263_27142616.0Nucleotide bindingATP
TgeneHSF5chr17:48503750chr17:56499791ENST000003237774610_200573597.0DNA bindingOntology_term=ECO:0000250


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Fusion Gene Sequence for ACSF2-HSF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1485_1485_1_ACSF2-HSF5_ACSF2_chr17_48503750_ENST00000300441_HSF5_chr17_56499791_ENST00000323777_length(transcript)=2496nt_BP=232nt
ATAGGCAGAGGCCACCCTCCCCGCCTCCCCGCCCGCTGCGCGCCCGCCCCGCCCCGGCTCACTTTAAAAGTTTACTCGGGCCGGGACGCA
GGGCAAAGCGAGCCATGGCTGTCTACGTCGGGATGCTGCGCCTGGGGAGGCTGTGCGCCGGGAGCTCGGGGGTGCTGGGGGCCCGGGCCG
CCCTCTCTCGGAGTTGGCAGGAAGCCAGGTTGCAGGGTGTCCGCTTCCTCAGATCTTCATCTGCTGGTGGACGTGGCCTGCAAGCAGGAG
CGCTTTCCAAAGGAGGAAGAATTAAAAGAGTGAGGAATGGATGACAAATGTGACATTGTGCACTAGCTGTAGCTGGAGGCAGACTAGCCT
TGCACATGACAAACTGTTGGGATTTTTTCAGTTCTGTTAAGGAAAAAAAAGTATTTTTTGTTTCGTTAATTGAGAATTTTGTTAATTGAG
AATTGGGAATTTGTATGTACTACAGTGGTTCAGTTCAGATTATCTGCCTTGACAAACTACTGAACATCTAGCAGCCACGTTTTTTGGCTG
CCCAGATCCCTTTTAAATGAAAAGTTCTGACCTTCTGTTATAGTCAAGGAGCATCTAAAAACTGCTCCATCTATGGTACTAAGAATAATC
TGTGTGTGTGCTGATTTGTTGTCTTGCCACTCAAACTGTAGTCAGCACAACTTTAGTGGGGAATTCAGTCTCTCTGATTCAAGTCACAGT
GTGATCCTTTTAGAGGAGATTGTGTGAGAAACAAAGGCATGTGAGGTCACCAGCATCACAGGTCTAAATGCATCAGGAATTCCAGGGAAG
AAACTCTGGAGAAGAGCTAATTTTCTAAGTGATTAACCAGGAAATTCTCTTACTTCCTAACCCAGCATTCTGTTTTAAGAGCAAGGCATC
CGGACTTGGACCATCTATCACACTTAACAGCCCCTGATTCTTTTATATTAATGGAAGCATTCTTCTATTTTCATATCTTTCTTTAATTTT
AATGATACATTATCATAAATGGTAAAAAGATTTTATTAATATATCACTTATTTAAATGTCTTTAAAGAAAGTATTTAACTTGTTTAATAT
AATTGTATTTATAAATGCTGATAGATTTAAAGGTTTTAAAGTTTTATATTTTTATTATTGCAGGATAGAAGGATAAAGGATGCATGTGTA
GTATTTTTATTTTGAAAGGAAAATGTACAATGTGTGAACAAAAACATTAAGAGATTTAATATACTATTTTCTTATTTTAGATTTTTACAT
TCAATAAGTATAAATTCTCATCTATATAAGGTATTGTGTGCAAATTTGGGAAAAAACTGATTAGCAGCCATTTAGTAGAAGCTATGCCTC
TGATTTTTAAAGAATGGTTTCAATCTGGTTTAAGCTTCTGAGAGAATTTTGGATAATGGGATAGATGGTAACATTTTTTTCTTATCCCTG
TTACAGGATTCTAGATTTGTGCAGTAGGATTGTGGGACTGTGTTTTAGGAGAGAAGGATGTCTTGGATGTCCAGTTTCTGTGGTTAATCC
CTTACTTGCTTATCCAGTGACAGCAAGAAACTTTCTGATTTAAAGTCTTTCAATTGACCAAAACTTTCTTATTGGATTCTGTTTCAGTTC
TCCTATTAAGCACTGCAGAAACGAAAGGAAAGCCTAGGAATATGAAACTAATTAAAAAGGCACTTGGTGATATGACATAGTACTATGCTA
GCCGTTGTGGATGTAACAGTTCATTTCTTATACTGCATTGTGCCTTCCCAATGATGTCAAACCCTAGAAATATTACAGAGATCTACTTTT
CTGGAAAAGGGTGAGCTCTGTATTGATCTGCAGTGACTCTGTTTAGATATTAAAGTAGGTTCTGAAAAGCGACCTGTGTGGTCCCTCTGA
TTAGACTAGTTAATGTCTATGTGATGGGCATTTATTTATCTTTATTAGCAAGGTTTAAAAGAGCAAATTATCAAGACACCTATATCTTTT
GGCCAGACTATATAATATTTTGTCAGAGTATGTGAAGAGGAGACCCAATTTCCAAATGAAGGAACTTTGCTTTTTCTCTGTCATGTTGAA
GAGCTAATATACTGTGTAGATTTTCCCCTAAATATGGCTTTCTTAGCTTTATAGATGTTGAGATAATATCTTTTGAGGAACACATGTCAA
GCAGGAACCTTGGCATAGATTTGGTTTCAGTTGTTTTAAGGCTTAATTAATGAAATGCCTTAATCAGCTTTCCAAACATTTTTATATATG
AATACAGCAGACCAAGGAGCTGGATCTCCTGCTATCCTTACACGCCTTGTATCTATCAACTAAAGCTGTCATTAATGACTTGGGCAAAAT
GGCAAGAGGTATAATAAAGTCTTCCTGTGAATTAGCCAGTAGGGTCTGACACAACTAGTCAACTAACAAGGTTCCTGACTAGTACCTCAG

>1485_1485_1_ACSF2-HSF5_ACSF2_chr17_48503750_ENST00000300441_HSF5_chr17_56499791_ENST00000323777_length(amino acids)=92AA_BP=65
MRARPAPAHFKSLLGPGRRAKRAMAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLRSSSAGGRGLQAGALSKGGRIKRVR

--------------------------------------------------------------
>1485_1485_2_ACSF2-HSF5_ACSF2_chr17_48503750_ENST00000427954_HSF5_chr17_56499791_ENST00000323777_length(transcript)=2435nt_BP=171nt
CTTTAAAAGTTTACTCGGGCCGGGACGCAGGGCAAAGCGAGCCATGGCTGTCTACGTCGGGATGCTGCGCCTGGGGAGGCTGTGCGCCGG
GAGCTCGGGGGTGCTGGGGGCCCGGGCCGCCCTCTCTCGGAGTTGGCAGGAAGCCAGGTTGCAGGGTGTCCGCTTCCTCAGATCTTCATC
TGCTGGTGGACGTGGCCTGCAAGCAGGAGCGCTTTCCAAAGGAGGAAGAATTAAAAGAGTGAGGAATGGATGACAAATGTGACATTGTGC
ACTAGCTGTAGCTGGAGGCAGACTAGCCTTGCACATGACAAACTGTTGGGATTTTTTCAGTTCTGTTAAGGAAAAAAAAGTATTTTTTGT
TTCGTTAATTGAGAATTTTGTTAATTGAGAATTGGGAATTTGTATGTACTACAGTGGTTCAGTTCAGATTATCTGCCTTGACAAACTACT
GAACATCTAGCAGCCACGTTTTTTGGCTGCCCAGATCCCTTTTAAATGAAAAGTTCTGACCTTCTGTTATAGTCAAGGAGCATCTAAAAA
CTGCTCCATCTATGGTACTAAGAATAATCTGTGTGTGTGCTGATTTGTTGTCTTGCCACTCAAACTGTAGTCAGCACAACTTTAGTGGGG
AATTCAGTCTCTCTGATTCAAGTCACAGTGTGATCCTTTTAGAGGAGATTGTGTGAGAAACAAAGGCATGTGAGGTCACCAGCATCACAG
GTCTAAATGCATCAGGAATTCCAGGGAAGAAACTCTGGAGAAGAGCTAATTTTCTAAGTGATTAACCAGGAAATTCTCTTACTTCCTAAC
CCAGCATTCTGTTTTAAGAGCAAGGCATCCGGACTTGGACCATCTATCACACTTAACAGCCCCTGATTCTTTTATATTAATGGAAGCATT
CTTCTATTTTCATATCTTTCTTTAATTTTAATGATACATTATCATAAATGGTAAAAAGATTTTATTAATATATCACTTATTTAAATGTCT
TTAAAGAAAGTATTTAACTTGTTTAATATAATTGTATTTATAAATGCTGATAGATTTAAAGGTTTTAAAGTTTTATATTTTTATTATTGC
AGGATAGAAGGATAAAGGATGCATGTGTAGTATTTTTATTTTGAAAGGAAAATGTACAATGTGTGAACAAAAACATTAAGAGATTTAATA
TACTATTTTCTTATTTTAGATTTTTACATTCAATAAGTATAAATTCTCATCTATATAAGGTATTGTGTGCAAATTTGGGAAAAAACTGAT
TAGCAGCCATTTAGTAGAAGCTATGCCTCTGATTTTTAAAGAATGGTTTCAATCTGGTTTAAGCTTCTGAGAGAATTTTGGATAATGGGA
TAGATGGTAACATTTTTTTCTTATCCCTGTTACAGGATTCTAGATTTGTGCAGTAGGATTGTGGGACTGTGTTTTAGGAGAGAAGGATGT
CTTGGATGTCCAGTTTCTGTGGTTAATCCCTTACTTGCTTATCCAGTGACAGCAAGAAACTTTCTGATTTAAAGTCTTTCAATTGACCAA
AACTTTCTTATTGGATTCTGTTTCAGTTCTCCTATTAAGCACTGCAGAAACGAAAGGAAAGCCTAGGAATATGAAACTAATTAAAAAGGC
ACTTGGTGATATGACATAGTACTATGCTAGCCGTTGTGGATGTAACAGTTCATTTCTTATACTGCATTGTGCCTTCCCAATGATGTCAAA
CCCTAGAAATATTACAGAGATCTACTTTTCTGGAAAAGGGTGAGCTCTGTATTGATCTGCAGTGACTCTGTTTAGATATTAAAGTAGGTT
CTGAAAAGCGACCTGTGTGGTCCCTCTGATTAGACTAGTTAATGTCTATGTGATGGGCATTTATTTATCTTTATTAGCAAGGTTTAAAAG
AGCAAATTATCAAGACACCTATATCTTTTGGCCAGACTATATAATATTTTGTCAGAGTATGTGAAGAGGAGACCCAATTTCCAAATGAAG
GAACTTTGCTTTTTCTCTGTCATGTTGAAGAGCTAATATACTGTGTAGATTTTCCCCTAAATATGGCTTTCTTAGCTTTATAGATGTTGA
GATAATATCTTTTGAGGAACACATGTCAAGCAGGAACCTTGGCATAGATTTGGTTTCAGTTGTTTTAAGGCTTAATTAATGAAATGCCTT
AATCAGCTTTCCAAACATTTTTATATATGAATACAGCAGACCAAGGAGCTGGATCTCCTGCTATCCTTACACGCCTTGTATCTATCAACT
AAAGCTGTCATTAATGACTTGGGCAAAATGGCAAGAGGTATAATAAAGTCTTCCTGTGAATTAGCCAGTAGGGTCTGACACAACTAGTCA
ACTAACAAGGTTCCTGACTAGTACCTCAGTATTTCAGCACCTTAAGCACTGATAAATTTCAATCAGTCAACAATAAAGTGAGTGTTCCAA

>1485_1485_2_ACSF2-HSF5_ACSF2_chr17_48503750_ENST00000427954_HSF5_chr17_56499791_ENST00000323777_length(amino acids)=69AA_BP=42

--------------------------------------------------------------
>1485_1485_3_ACSF2-HSF5_ACSF2_chr17_48503750_ENST00000502667_HSF5_chr17_56499791_ENST00000323777_length(transcript)=2402nt_BP=138nt
AAAGCGAGCCATGGCTGTCTACGTCGGGATGCTGCGCCTGGGGAGGCTGTGCGCCGGGAGCTCGGGGGTGCTGGGGGCCCGGGCCGCCCT
CTCTCGGAGTTGGCAGGAAGCCAGGTTGCAGGGTGTCCGCTTCCTCAGATCTTCATCTGCTGGTGGACGTGGCCTGCAAGCAGGAGCGCT
TTCCAAAGGAGGAAGAATTAAAAGAGTGAGGAATGGATGACAAATGTGACATTGTGCACTAGCTGTAGCTGGAGGCAGACTAGCCTTGCA
CATGACAAACTGTTGGGATTTTTTCAGTTCTGTTAAGGAAAAAAAAGTATTTTTTGTTTCGTTAATTGAGAATTTTGTTAATTGAGAATT
GGGAATTTGTATGTACTACAGTGGTTCAGTTCAGATTATCTGCCTTGACAAACTACTGAACATCTAGCAGCCACGTTTTTTGGCTGCCCA
GATCCCTTTTAAATGAAAAGTTCTGACCTTCTGTTATAGTCAAGGAGCATCTAAAAACTGCTCCATCTATGGTACTAAGAATAATCTGTG
TGTGTGCTGATTTGTTGTCTTGCCACTCAAACTGTAGTCAGCACAACTTTAGTGGGGAATTCAGTCTCTCTGATTCAAGTCACAGTGTGA
TCCTTTTAGAGGAGATTGTGTGAGAAACAAAGGCATGTGAGGTCACCAGCATCACAGGTCTAAATGCATCAGGAATTCCAGGGAAGAAAC
TCTGGAGAAGAGCTAATTTTCTAAGTGATTAACCAGGAAATTCTCTTACTTCCTAACCCAGCATTCTGTTTTAAGAGCAAGGCATCCGGA
CTTGGACCATCTATCACACTTAACAGCCCCTGATTCTTTTATATTAATGGAAGCATTCTTCTATTTTCATATCTTTCTTTAATTTTAATG
ATACATTATCATAAATGGTAAAAAGATTTTATTAATATATCACTTATTTAAATGTCTTTAAAGAAAGTATTTAACTTGTTTAATATAATT
GTATTTATAAATGCTGATAGATTTAAAGGTTTTAAAGTTTTATATTTTTATTATTGCAGGATAGAAGGATAAAGGATGCATGTGTAGTAT
TTTTATTTTGAAAGGAAAATGTACAATGTGTGAACAAAAACATTAAGAGATTTAATATACTATTTTCTTATTTTAGATTTTTACATTCAA
TAAGTATAAATTCTCATCTATATAAGGTATTGTGTGCAAATTTGGGAAAAAACTGATTAGCAGCCATTTAGTAGAAGCTATGCCTCTGAT
TTTTAAAGAATGGTTTCAATCTGGTTTAAGCTTCTGAGAGAATTTTGGATAATGGGATAGATGGTAACATTTTTTTCTTATCCCTGTTAC
AGGATTCTAGATTTGTGCAGTAGGATTGTGGGACTGTGTTTTAGGAGAGAAGGATGTCTTGGATGTCCAGTTTCTGTGGTTAATCCCTTA
CTTGCTTATCCAGTGACAGCAAGAAACTTTCTGATTTAAAGTCTTTCAATTGACCAAAACTTTCTTATTGGATTCTGTTTCAGTTCTCCT
ATTAAGCACTGCAGAAACGAAAGGAAAGCCTAGGAATATGAAACTAATTAAAAAGGCACTTGGTGATATGACATAGTACTATGCTAGCCG
TTGTGGATGTAACAGTTCATTTCTTATACTGCATTGTGCCTTCCCAATGATGTCAAACCCTAGAAATATTACAGAGATCTACTTTTCTGG
AAAAGGGTGAGCTCTGTATTGATCTGCAGTGACTCTGTTTAGATATTAAAGTAGGTTCTGAAAAGCGACCTGTGTGGTCCCTCTGATTAG
ACTAGTTAATGTCTATGTGATGGGCATTTATTTATCTTTATTAGCAAGGTTTAAAAGAGCAAATTATCAAGACACCTATATCTTTTGGCC
AGACTATATAATATTTTGTCAGAGTATGTGAAGAGGAGACCCAATTTCCAAATGAAGGAACTTTGCTTTTTCTCTGTCATGTTGAAGAGC
TAATATACTGTGTAGATTTTCCCCTAAATATGGCTTTCTTAGCTTTATAGATGTTGAGATAATATCTTTTGAGGAACACATGTCAAGCAG
GAACCTTGGCATAGATTTGGTTTCAGTTGTTTTAAGGCTTAATTAATGAAATGCCTTAATCAGCTTTCCAAACATTTTTATATATGAATA
CAGCAGACCAAGGAGCTGGATCTCCTGCTATCCTTACACGCCTTGTATCTATCAACTAAAGCTGTCATTAATGACTTGGGCAAAATGGCA
AGAGGTATAATAAAGTCTTCCTGTGAATTAGCCAGTAGGGTCTGACACAACTAGTCAACTAACAAGGTTCCTGACTAGTACCTCAGTATT

>1485_1485_3_ACSF2-HSF5_ACSF2_chr17_48503750_ENST00000502667_HSF5_chr17_56499791_ENST00000323777_length(amino acids)=69AA_BP=42

--------------------------------------------------------------
>1485_1485_4_ACSF2-HSF5_ACSF2_chr17_48503750_ENST00000504392_HSF5_chr17_56499791_ENST00000323777_length(transcript)=2436nt_BP=172nt
ACTTTAAAAGTTTACTCGGGCCGGGACGCAGGGCAAAGCGAGCCATGGCTGTCTACGTCGGGATGCTGCGCCTGGGGAGGCTGTGCGCCG
GGAGCTCGGGGGTGCTGGGGGCCCGGGCCGCCCTCTCTCGGAGTTGGCAGGAAGCCAGGTTGCAGGGTGTCCGCTTCCTCAGATCTTCAT
CTGCTGGTGGACGTGGCCTGCAAGCAGGAGCGCTTTCCAAAGGAGGAAGAATTAAAAGAGTGAGGAATGGATGACAAATGTGACATTGTG
CACTAGCTGTAGCTGGAGGCAGACTAGCCTTGCACATGACAAACTGTTGGGATTTTTTCAGTTCTGTTAAGGAAAAAAAAGTATTTTTTG
TTTCGTTAATTGAGAATTTTGTTAATTGAGAATTGGGAATTTGTATGTACTACAGTGGTTCAGTTCAGATTATCTGCCTTGACAAACTAC
TGAACATCTAGCAGCCACGTTTTTTGGCTGCCCAGATCCCTTTTAAATGAAAAGTTCTGACCTTCTGTTATAGTCAAGGAGCATCTAAAA
ACTGCTCCATCTATGGTACTAAGAATAATCTGTGTGTGTGCTGATTTGTTGTCTTGCCACTCAAACTGTAGTCAGCACAACTTTAGTGGG
GAATTCAGTCTCTCTGATTCAAGTCACAGTGTGATCCTTTTAGAGGAGATTGTGTGAGAAACAAAGGCATGTGAGGTCACCAGCATCACA
GGTCTAAATGCATCAGGAATTCCAGGGAAGAAACTCTGGAGAAGAGCTAATTTTCTAAGTGATTAACCAGGAAATTCTCTTACTTCCTAA
CCCAGCATTCTGTTTTAAGAGCAAGGCATCCGGACTTGGACCATCTATCACACTTAACAGCCCCTGATTCTTTTATATTAATGGAAGCAT
TCTTCTATTTTCATATCTTTCTTTAATTTTAATGATACATTATCATAAATGGTAAAAAGATTTTATTAATATATCACTTATTTAAATGTC
TTTAAAGAAAGTATTTAACTTGTTTAATATAATTGTATTTATAAATGCTGATAGATTTAAAGGTTTTAAAGTTTTATATTTTTATTATTG
CAGGATAGAAGGATAAAGGATGCATGTGTAGTATTTTTATTTTGAAAGGAAAATGTACAATGTGTGAACAAAAACATTAAGAGATTTAAT
ATACTATTTTCTTATTTTAGATTTTTACATTCAATAAGTATAAATTCTCATCTATATAAGGTATTGTGTGCAAATTTGGGAAAAAACTGA
TTAGCAGCCATTTAGTAGAAGCTATGCCTCTGATTTTTAAAGAATGGTTTCAATCTGGTTTAAGCTTCTGAGAGAATTTTGGATAATGGG
ATAGATGGTAACATTTTTTTCTTATCCCTGTTACAGGATTCTAGATTTGTGCAGTAGGATTGTGGGACTGTGTTTTAGGAGAGAAGGATG
TCTTGGATGTCCAGTTTCTGTGGTTAATCCCTTACTTGCTTATCCAGTGACAGCAAGAAACTTTCTGATTTAAAGTCTTTCAATTGACCA
AAACTTTCTTATTGGATTCTGTTTCAGTTCTCCTATTAAGCACTGCAGAAACGAAAGGAAAGCCTAGGAATATGAAACTAATTAAAAAGG
CACTTGGTGATATGACATAGTACTATGCTAGCCGTTGTGGATGTAACAGTTCATTTCTTATACTGCATTGTGCCTTCCCAATGATGTCAA
ACCCTAGAAATATTACAGAGATCTACTTTTCTGGAAAAGGGTGAGCTCTGTATTGATCTGCAGTGACTCTGTTTAGATATTAAAGTAGGT
TCTGAAAAGCGACCTGTGTGGTCCCTCTGATTAGACTAGTTAATGTCTATGTGATGGGCATTTATTTATCTTTATTAGCAAGGTTTAAAA
GAGCAAATTATCAAGACACCTATATCTTTTGGCCAGACTATATAATATTTTGTCAGAGTATGTGAAGAGGAGACCCAATTTCCAAATGAA
GGAACTTTGCTTTTTCTCTGTCATGTTGAAGAGCTAATATACTGTGTAGATTTTCCCCTAAATATGGCTTTCTTAGCTTTATAGATGTTG
AGATAATATCTTTTGAGGAACACATGTCAAGCAGGAACCTTGGCATAGATTTGGTTTCAGTTGTTTTAAGGCTTAATTAATGAAATGCCT
TAATCAGCTTTCCAAACATTTTTATATATGAATACAGCAGACCAAGGAGCTGGATCTCCTGCTATCCTTACACGCCTTGTATCTATCAAC
TAAAGCTGTCATTAATGACTTGGGCAAAATGGCAAGAGGTATAATAAAGTCTTCCTGTGAATTAGCCAGTAGGGTCTGACACAACTAGTC
AACTAACAAGGTTCCTGACTAGTACCTCAGTATTTCAGCACCTTAAGCACTGATAAATTTCAATCAGTCAACAATAAAGTGAGTGTTCCA

>1485_1485_4_ACSF2-HSF5_ACSF2_chr17_48503750_ENST00000504392_HSF5_chr17_56499791_ENST00000323777_length(amino acids)=69AA_BP=42

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACSF2-HSF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACSF2-HSF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACSF2-HSF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource