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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CDC42BPB-NEDD4L (FusionGDB2 ID:14854) |
Fusion Gene Summary for CDC42BPB-NEDD4L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDC42BPB-NEDD4L | Fusion gene ID: 14854 | Hgene | Tgene | Gene symbol | CDC42BPB | NEDD4L | Gene ID | 9578 | 23327 |
| Gene name | CDC42 binding protein kinase beta | NEDD4 like E3 ubiquitin protein ligase | |
| Synonyms | MRCKB | NEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2 | |
| Cytomap | 14q32.32 | 18q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase MRCK betaCDC42 binding protein kinase beta (DMPK-like)CDC42BP-betaDMPK-like betaMRCK betamyotonic dystrophy kinase-related CDC42-binding kinase betamyotonic dystrophy protein kinase-like beta | E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseubiquitin-protein ligase Rsp5 | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | Q9Y5S2 | Q96PU5 | |
| Ensembl transtripts involved in fusion gene | ENST00000361246, | ENST00000256830, ENST00000256832, ENST00000356462, ENST00000357895, ENST00000382850, ENST00000400345, ENST00000431212, ENST00000435432, ENST00000456173, ENST00000456986, ENST00000586263, ENST00000588516, ENST00000589054, | |
| Fusion gene scores | * DoF score | 17 X 16 X 10=2720 | 27 X 28 X 6=4536 |
| # samples | 19 | 32 | |
| ** MAII score | log2(19/2720*10)=-3.83953532780675 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(32/4536*10)=-3.82527683005487 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CDC42BPB [Title/Abstract] AND NEDD4L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CDC42BPB(103432700)-NEDD4L(56001124), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDC42BPB | GO:0006468 | protein phosphorylation | 21949762 |
| Tgene | NEDD4L | GO:0003254 | regulation of membrane depolarization | 15217910 |
| Tgene | NEDD4L | GO:0006511 | ubiquitin-dependent protein catabolic process | 21463633 |
| Tgene | NEDD4L | GO:0010038 | response to metal ion | 11244092 |
| Tgene | NEDD4L | GO:0016567 | protein ubiquitination | 15217910|25631046 |
| Tgene | NEDD4L | GO:0034765 | regulation of ion transmembrane transport | 17289006 |
| Tgene | NEDD4L | GO:0042391 | regulation of membrane potential | 17289006 |
| Tgene | NEDD4L | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 21463633 |
| Tgene | NEDD4L | GO:0060306 | regulation of membrane repolarization | 21463633 |
| Tgene | NEDD4L | GO:0070936 | protein K48-linked ubiquitination | 21463633 |
| Tgene | NEDD4L | GO:1901016 | regulation of potassium ion transmembrane transporter activity | 17289006 |
| Tgene | NEDD4L | GO:1901017 | negative regulation of potassium ion transmembrane transporter activity | 21463633 |
| Tgene | NEDD4L | GO:1901380 | negative regulation of potassium ion transmembrane transport | 21463633 |
| Tgene | NEDD4L | GO:1902306 | negative regulation of sodium ion transmembrane transport | 15217910 |
| Tgene | NEDD4L | GO:1903861 | positive regulation of dendrite extension | 23999003 |
| Tgene | NEDD4L | GO:2000009 | negative regulation of protein localization to cell surface | 21463633 |
| Tgene | NEDD4L | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity | 15217910 |
| Fusion gene breakpoints across CDC42BPB (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across NEDD4L (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BF834550 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
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Fusion Gene ORF analysis for CDC42BPB-NEDD4L |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000361246 | ENST00000256830 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000256832 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000356462 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000357895 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000382850 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000400345 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000431212 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000435432 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000456173 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000456986 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000586263 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000588516 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| intron-intron | ENST00000361246 | ENST00000589054 | CDC42BPB | chr14 | 103432700 | + | NEDD4L | chr18 | 56001124 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CDC42BPB-NEDD4L |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CDC42BPB-NEDD4L |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:103432700/:56001124) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDC42BPB | NEDD4L |
| FUNCTION: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. | FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CDC42BPB-NEDD4L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for CDC42BPB-NEDD4L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CDC42BPB-NEDD4L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CDC42BPB-NEDD4L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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