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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CDC6-CCR7 (FusionGDB2 ID:14930)

Fusion Gene Summary for CDC6-CCR7

Fusion gene summary

Fusion gene information	Fusion gene name: CDC6-CCR7
	Fusion gene ID: 14930
		Hgene	Tgene
	Gene symbol	CDC6	CCR7
	Gene ID	990	1236
	Gene name	cell division cycle 6	C-C motif chemokine receptor 7
	Synonyms	CDC18L\|HsCDC18\|HsCDC6\|MGORS5	BLR2\|CC-CKR-7\|CCR-7\|CD197\|CDw197\|CMKBR7\|EBI1
	Cytomap	17q21.2	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	cell division control protein 6 homologCDC6 cell division cycle 6 homologCDC6-related proteincdc18-related proteincell division cycle 6 homologp62(cdc6)	C-C chemokine receptor type 7Bukitt's lymphoma receptor 2CC chemokine receptor 7EBV-induced G protein-coupled receptor 1Epstein-Barr virus induced gene 1Epstein-Barr virus-induced G-protein coupled receptor 1MIP-3 beta receptorchemokine (C-C motif)
	Modification date	20200313	20200322
	UniProtAcc	Q99741	.
	Ensembl transtripts involved in fusion gene	ENST00000209728,	ENST00000579344, ENST00000246657,
Fusion gene scores	* DoF score	12 X 12 X 6=864	7 X 2 X 7=98
	# samples	12	9
	** MAII score	log2(12/864*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/98*10)=-0.122856747785533 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CDC6 [Title/Abstract] AND CCR7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CDC6(38451708)-CCR7(38715194), # samples:2
Anticipated loss of major functional domain due to fusion event.	CDC6-CCR7 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. CDC6-CCR7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CDC6-CCR7 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. CDC6-CCR7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDC6	GO:0051984	positive regulation of chromosome segregation	21041660
Tgene	CCR7	GO:0002408	myeloid dendritic cell chemotaxis	11602640
Tgene	CCR7	GO:0071345	cellular response to cytokine stimulus	11602640
Tgene	CCR7	GO:0090023	positive regulation of neutrophil chemotaxis	21051556

Fusion gene breakpoints across CDC6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCR7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-EQ-8122-01A	CDC6	chr17	38451708	+	CCR7	chr17	38715194	-
ChimerDB4	STAD	TCGA-EQ-8122-01A	CDC6	chr17	38453019	+	CCR7	chr17	38715194	-

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Fusion Gene ORF analysis for CDC6-CCR7

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000209728	ENST00000579344	CDC6	chr17	38451708	+	CCR7	chr17	38715194	-
5CDS-5UTR	ENST00000209728	ENST00000579344	CDC6	chr17	38453019	+	CCR7	chr17	38715194	-
Frame-shift	ENST00000209728	ENST00000246657	CDC6	chr17	38451708	+	CCR7	chr17	38715194	-
In-frame	ENST00000209728	ENST00000246657	CDC6	chr17	38453019	+	CCR7	chr17	38715194	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000209728

CDC6

chr17

38453019

ENST00000246657

CCR7

chr17

38715194

3820

1720

363

2846

827

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000209728	ENST00000246657	CDC6	chr17	38453019	+	CCR7	chr17	38715194	-	0.002508739	0.99749124

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Fusion Genomic Features for CDC6-CCR7

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDC6-CCR7

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38451708/chr17:38715194)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDC6 Q99741	.
FUNCTION: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDC6

chr17:38453019

chr17:38715194

ENST00000209728

202_209

416

561.0

Nucleotide binding

ATP

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

117_130

379.0

Topological domain

Extracellular

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

153_170

379.0

Topological domain

Cytoplasmic

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

192_219

379.0

Topological domain

Extracellular

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

248_263

379.0

Topological domain

Cytoplasmic

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

25_59

379.0

Topological domain

Extracellular

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

290_313

379.0

Topological domain

Extracellular

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

332_378

379.0

Topological domain

Cytoplasmic

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

87_95

379.0

Topological domain

Cytoplasmic

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

131_152

379.0

Transmembrane

Helical%3B Name%3D3

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

171_191

379.0

Transmembrane

Helical%3B Name%3D4

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

220_247

379.0

Transmembrane

Helical%3B Name%3D5

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

264_289

379.0

Transmembrane

Helical%3B Name%3D6

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

314_331

379.0

Transmembrane

Helical%3B Name%3D7

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

60_86

379.0

Transmembrane

Helical%3B Name%3D1

Tgene

CCR7

chr17:38453019

chr17:38715194

ENST00000246657

96_116

379.0

Transmembrane

Helical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CDC6-CCR7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>14930_14930_1_CDC6-CCR7_CDC6_chr17_38453019_ENST00000209728_CCR7_chr17_38715194_ENST00000246657_length(transcript)=3820nt_BP=1720nt
GCTTTACCCAGAGTCGCCCTGCCGCAATCGCGCGTCTTTCCACCGAGGCCCCGGATGTAGATTCCCTCCCCCGTTCAGTGGTCGTGGCCT
CACAGCGACTCTAAGACTTGGGGCTCTCTCATTGGCTGTAACTCTTCCACTGGATTGGTAGCAAAAAAAGAGGCGGTGCCCAAGGCGAAA
GGCTCTGTGACTACAGCCAATCAGAATCGAGGCCGGGCTTTGGCGGGAGGTGGGAACGCTGTGGCCATTCGGATTTGGCGCGAGCGCGGC
TGGAGTTTGCTGCTGCCGCTGTGCAGTTTGTTCAGGGGCTTGTGGTGGTGAGTCCGAGAGGCTGCGTGTGAGAGACGTGAGAAGGATCCT
GCACTGAGGAGGTGGAAAGAAGAGGATTGCTCGAGGAGGCCTGGGGTCTGTGAGGCAGCGGAGCTGGGTGAAGGCTGCGGGTTCCGGCGA
GGCCTGAGCTGTGCTGTCGTCATGCCTCAAACCCGATCCCAGGCACAGGCTACAATCAGTTTTCCAAAAAGGAAGCTGTCTCGGGCATTG
AACAAAGCTAAAAACTCCAGTGATGCCAAACTAGAACCAACAAATGTCCAAACCGTAACCTGTTCTCCTCGTGTAAAAGCCCTGCCTCTC
AGCCCCAGGAAACGTCTGGGCGATGACAACCTATGCAACACTCCCCATTTACCTCCTTGTTCTCCACCAAAGCAAGGCAAGAAAGAGAAT
GGTCCCCCTCACTCACATACACTTAAGGGACGAAGATTGGTATTTGACAATCAGCTGACAATTAAGTCTCCTAGCAAAAGAGAACTAGCC
AAAGTTCACCAAAACAAAATACTTTCTTCAGTTAGAAAAAGTCAAGAGATCACAACAAATTCTGAGCAGAGATGTCCACTGAAGAAAGAA
TCTGCATGTGTGAGACTATTCAAGCAAGAAGGCACTTGCTACCAGCAAGCAAAGCTGGTCCTGAACACAGCTGTCCCAGATCGGCTGCCT
GCCAGGGAAAGGGAGATGGATGTCATCAGGAATTTCTTGAGGGAACACATCTGTGGGAAAAAAGCTGGAAGCCTTTACCTTTCTGGTGCT
CCTGGAACTGGAAAAACTGCCTGCTTAAGCCGGATTCTGCAAGACCTCAAGAAGGAACTGAAAGGCTTTAAAACTATCATGCTGAATTGC
ATGTCCTTGAGGACTGCCCAGGCTGTATTCCCAGCTATTGCTCAGGAGATTTGTCAGGAAGAGGTATCCAGGCCAGCTGGGAAGGACATG
ATGAGGAAATTGGAAAAACATATGACTGCAGAGAAGGGCCCCATGATTGTGTTGGTATTGGACGAGATGGATCAACTGGACAGCAAAGGC
CAGGATGTATTGTACACGCTATTTGAATGGCCATGGCTAAGCAATTCTCACTTGGTGCTGATTGGTATTGCTAATACCCTGGATCTCACA
GATAGAATTCTACCTAGGCTTCAAGCTAGAGAAAAATGTAAGCCACAGCTGTTGAACTTCCCACCTTATACCAGAAATCAGATAGTCACT
ATTTTGCAAGATCGACTTAATCAGGTATCTAGAGATCAGGTTCTGGACAATGCTGCAGTTCAATTCTGTGCCCGCAAAGTCTCTGCTGTT
TCAGGAGATGTTCGCAAAGCACTGGATGTTTGCAGGAGAGCTATTGAAATTGTAGAGTCAGATGTCAAAAGCCAGACTATTCTCAAACCA
CTGTCTGAATGGAAACCAATGAAAAGCGTGCTGGTGGTGGCTCTCCTTGTCATTTTCCAGGTATGCCTGTGTCAAGATGAGGTCACGGAC
GATTACATCGGAGACAACACCACAGTGGACTACACTTTGTTCGAGTCTTTGTGCTCCAAGAAGGACGTGCGGAACTTTAAAGCCTGGTTC
CTCCCTATCATGTACTCCATCATTTGTTTCGTGGGCCTACTGGGCAATGGGCTGGTCGTGTTGACCTATATCTATTTCAAGAGGCTCAAG
ACCATGACCGATACCTACCTGCTCAACCTGGCGGTGGCAGACATCCTCTTCCTCCTGACCCTTCCCTTCTGGGCCTACAGCGCGGCCAAG
TCCTGGGTCTTCGGTGTCCACTTTTGCAAGCTCATCTTTGCCATCTACAAGATGAGCTTCTTCAGTGGCATGCTCCTACTTCTTTGCATC
AGCATTGACCGCTACGTGGCCATCGTCCAGGCTGTCTCAGCTCACCGCCACCGTGCCCGCGTCCTTCTCATCAGCAAGCTGTCCTGTGTG
GGCATCTGGATACTAGCCACAGTGCTCTCCATCCCAGAGCTCCTGTACAGTGACCTCCAGAGGAGCAGCAGTGAGCAAGCGATGCGATGC
TCTCTCATCACAGAGCATGTGGAGGCCTTTATCACCATCCAGGTGGCCCAGATGGTGATCGGCTTTCTGGTCCCCCTGCTGGCCATGAGC
TTCTGTTACCTTGTCATCATCCGCACCCTGCTCCAGGCACGCAACTTTGAGCGCAACAAGGCCATCAAGGTGATCATCGCTGTGGTCGTG
GTCTTCATAGTCTTCCAGCTGCCCTACAATGGGGTGGTCCTGGCCCAGACGGTGGCCAACTTCAACATCACCAGTAGCACCTGTGAGCTC
AGTAAGCAACTCAACATCGCCTACGACGTCACCTACAGCCTGGCCTGCGTCCGCTGCTGCGTCAACCCTTTCTTGTACGCCTTCATCGGC
GTCAAGTTCCGCAACGATCTCTTCAAGCTCTTCAAGGACCTGGGCTGCCTCAGCCAGGAGCAGCTCCGGCAGTGGTCTTCCTGTCGGCAC
ATCCGGCGCTCCTCCATGAGTGTGGAGGCCGAGACCACCACCACCTTCTCCCCATAGGCGACTCTTCTGCCTGGACTAGAGGGACCTCTC
CCAGGGTCCCTGGGGTGGGGATAGGGAGCAGATGCAATGACTCAGGACATCCCCCCGCCAAAAGCTGCTCAGGGAAAAGCAGCTCTCCCC
TCAGAGTGCAAGCCCCTGCTCCAGAAGATAGCTTCACCCCAATCCCAGCTACCTCAACCAATGCCAAAAAAAGACAGGGCTGATAAGCTA
ACACCAGACAGACAACACTGGGAAACAGAGGCTATTGTCCCCTAAACCAAAAACTGAAAGTGAAAGTCCAGAAACTGTTCCCACCTGCTG
GAGTGAAGGGGCCAAGGAGGGTGAGTGCAAGGGGCGTGGGAGTGGCCTGAAGAGTCCTCTGAATGAACCTTCTGGCCTCCCACAGACTCA
AATGCTCAGACCAGCTCTTCCGAAAACCAGGCCTTATCTCCAAGACCAGAGATAGTGGGGAGACTTCTTGGCTTGGTGAGGAAAAGCGGA
CATCAGCTGGTCAAACAAACTCTCTGAACCCCTCCCTCCATCGTTTTCTTCACTGTCCTCCAAGCCAGCGGGAATGGCAGCTGCCACGCC
GCCCTAAAAGCACACTCATCCCCTCACTTGCCGCGTCGCCCTCCCAGGCTCTCAACAGGGGAGAGTGTGGTGTTTCCTGCAGGCCAGGCC
AGCTGCCTCCGCGTGATCAAAGCCACACTCTGGGCTCCAGAGTGGGGATGACATGCACTCAGCTCTTGGCTCCACTGGGATGGGAGGAGA
GGACAAGGGAAATGTCAGGGGCGGGGAGGGTGACAGTGGCCGCCCAAGGCCCACGAGCTTGTTCTTTGTTCTTTGTCACAGGGACTGAAA
ACCTCTCCTCATGTTCTGCTTTCGATTCGTTAAGAGAGCAACATTTTACCCACACACAGATAAAGTTTTCCCTTGAGGAAACAACAGCTT

>14930_14930_1_CDC6-CCR7_CDC6_chr17_38453019_ENST00000209728_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=827AA_BP=453
MRRWKEEDCSRRPGVCEAAELGEGCGFRRGLSCAVVMPQTRSQAQATISFPKRKLSRALNKAKNSSDAKLEPTNVQTVTCSPRVKALPLS
PRKRLGDDNLCNTPHLPPCSPPKQGKKENGPPHSHTLKGRRLVFDNQLTIKSPSKRELAKVHQNKILSSVRKSQEITTNSEQRCPLKKES
ACVRLFKQEGTCYQQAKLVLNTAVPDRLPAREREMDVIRNFLREHICGKKAGSLYLSGAPGTGKTACLSRILQDLKKELKGFKTIMLNCM
SLRTAQAVFPAIAQEICQEEVSRPAGKDMMRKLEKHMTAEKGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSHLVLIGIANTLDLTD
RILPRLQAREKCKPQLLNFPPYTRNQIVTILQDRLNQVSRDQVLDNAAVQFCARKVSAVSGDVRKALDVCRRAIEIVESDVKSQTILKPL
SEWKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKT
MTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVG
IWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVV
FIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRHI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDC6-CCR7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CDC6-CCR7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CDC6-CCR7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source