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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDH18-TERT (FusionGDB2 ID:15025)

Fusion Gene Summary for CDH18-TERT

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH18-TERT
Fusion gene ID: 15025
HgeneTgene
Gene symbol

CDH18

TERT

Gene ID

1016

7015

Gene namecadherin 18telomerase reverse transcriptase
SynonymsCDH14|CDH14L|CDH24CMM9|DKCA2|DKCB4|EST2|PFBMFT1|TCS1|TP2|TRT|hEST2|hTRT
Cytomap

5p14.3

5p15.33

Type of geneprotein-codingprotein-coding
Descriptioncadherin-18cadherin 18, type 2cadherin-14cadherin-like 24ey-cadherintelomerase reverse transcriptasetelomerase catalytic subunittelomerase-associated protein 2
Modification date2020031320200329
UniProtAcc

Q13634

.
Ensembl transtripts involved in fusion geneENST00000274170, ENST00000382275, 
ENST00000502796, ENST00000506372, 
ENST00000507958, ENST00000511273, 
ENST00000510297, 		ENST00000522877, 
ENST00000310581, ENST00000334602, 
ENST00000508104, ENST00000296820, 
Fusion gene scores* DoF score7 X 7 X 2=9822 X 7 X 15=2310
# samples 731
** MAII scorelog2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/2310*10)=-2.89755273102918
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDH18 [Title/Abstract] AND TERT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDH18(19612543)-TERT(1282739), # samples:2
Anticipated loss of major functional domain due to fusion event.CDH18-TERT seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTERT

GO:0001172

transcription, RNA-templated

19701182

TgeneTERT

GO:0006278

RNA-dependent DNA biosynthetic process

9398860

TgeneTERT

GO:0007004

telomere maintenance via telomerase

9443919|16043710|17940095|19701182|21531765|29695869

TgeneTERT

GO:0007005

mitochondrion organization

21937513

TgeneTERT

GO:0010629

negative regulation of gene expression

11927518

TgeneTERT

GO:0022616

DNA strand elongation

16043710

TgeneTERT

GO:0030422

production of siRNA involved in RNA interference

19701182

TgeneTERT

GO:0031647

regulation of protein stability

24415760|26194824

TgeneTERT

GO:0032092

positive regulation of protein binding

24415760

TgeneTERT

GO:0051000

positive regulation of nitric-oxide synthase activity

11927518

TgeneTERT

GO:0070200

establishment of protein localization to telomere

25589350

TgeneTERT

GO:0071897

DNA biosynthetic process

9398860|19701182

TgeneTERT

GO:1903704

negative regulation of production of siRNA involved in RNA interference

19701182

TgeneTERT

GO:1904751

positive regulation of protein localization to nucleolus

24415760

TgeneTERT

GO:2000773

negative regulation of cellular senescence

11927518


check buttonFusion gene breakpoints across CDH18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TERT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2G-01ACDH18chr5

19612543

-TERTchr5

1282739

-


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Fusion Gene ORF analysis for CDH18-TERT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000274170ENST00000522877CDH18chr5

19612543

-TERTchr5

1282739

-
5CDS-intronENST00000382275ENST00000522877CDH18chr5

19612543

-TERTchr5

1282739

-
5CDS-intronENST00000502796ENST00000522877CDH18chr5

19612543

-TERTchr5

1282739

-
5CDS-intronENST00000506372ENST00000522877CDH18chr5

19612543

-TERTchr5

1282739

-
5CDS-intronENST00000507958ENST00000522877CDH18chr5

19612543

-TERTchr5

1282739

-
5CDS-intronENST00000511273ENST00000522877CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000274170ENST00000310581CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000274170ENST00000334602CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000274170ENST00000508104CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000382275ENST00000296820CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000382275ENST00000310581CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000382275ENST00000334602CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000382275ENST00000508104CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000502796ENST00000296820CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000502796ENST00000310581CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000502796ENST00000334602CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000502796ENST00000508104CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000506372ENST00000310581CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000506372ENST00000334602CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000506372ENST00000508104CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000507958ENST00000296820CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000507958ENST00000310581CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000507958ENST00000334602CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000507958ENST00000508104CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000511273ENST00000310581CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000511273ENST00000334602CDH18chr5

19612543

-TERTchr5

1282739

-
Frame-shiftENST00000511273ENST00000508104CDH18chr5

19612543

-TERTchr5

1282739

-
In-frameENST00000274170ENST00000296820CDH18chr5

19612543

-TERTchr5

1282739

-
In-frameENST00000506372ENST00000296820CDH18chr5

19612543

-TERTchr5

1282739

-
In-frameENST00000511273ENST00000296820CDH18chr5

19612543

-TERTchr5

1282739

-
intron-3CDSENST00000510297ENST00000296820CDH18chr5

19612543

-TERTchr5

1282739

-
intron-3CDSENST00000510297ENST00000310581CDH18chr5

19612543

-TERTchr5

1282739

-
intron-3CDSENST00000510297ENST00000334602CDH18chr5

19612543

-TERTchr5

1282739

-
intron-3CDSENST00000510297ENST00000508104CDH18chr5

19612543

-TERTchr5

1282739

-
intron-intronENST00000510297ENST00000522877CDH18chr5

19612543

-TERTchr5

1282739

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000511273CDH18chr519612543-ENST00000296820TERTchr51282739-338711893602039559
ENST00000274170CDH18chr519612543-ENST00000296820TERTchr51282739-352113234942173559
ENST00000506372CDH18chr519612543-ENST00000296820TERTchr51282739-352113234942173559

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000511273ENST00000296820CDH18chr519612543-TERTchr51282739-0.0071742020.99282587
ENST00000274170ENST00000296820CDH18chr519612543-TERTchr51282739-0.0065557930.9934442
ENST00000506372ENST00000296820CDH18chr519612543-TERTchr51282739-0.0065557930.9934442

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Fusion Genomic Features for CDH18-TERT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDH18-TERT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:19612543/chr5:1282739)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH18

Q13634

.
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH18chr5:19612543chr5:1282739ENST00000274170-613160_268270791.0DomainCadherin 2
HgeneCDH18chr5:19612543chr5:1282739ENST00000274170-61354_159270791.0DomainCadherin 1
HgeneCDH18chr5:19612543chr5:1282739ENST00000382275-613160_268270791.0DomainCadherin 2
HgeneCDH18chr5:19612543chr5:1282739ENST00000382275-61354_159270791.0DomainCadherin 1
HgeneCDH18chr5:19612543chr5:1282739ENST00000502796-613160_268270595.6666666666666DomainCadherin 2
HgeneCDH18chr5:19612543chr5:1282739ENST00000502796-61354_159270595.6666666666666DomainCadherin 1
HgeneCDH18chr5:19612543chr5:1282739ENST00000507958-815160_268270791.0DomainCadherin 2
HgeneCDH18chr5:19612543chr5:1282739ENST00000507958-81554_159270791.0DomainCadherin 1
TgeneTERTchr5:19612543chr5:1282739ENST00000296820114605_935524445.6666666666667DomainReverse transcriptase
TgeneTERTchr5:19612543chr5:1282739ENST00000310581116605_9355241133.0DomainReverse transcriptase
TgeneTERTchr5:19612543chr5:1282739ENST00000334602115605_9355241070.0DomainReverse transcriptase
TgeneTERTchr5:19612543chr5:1282739ENST0000050810418605_935524808.0DomainReverse transcriptase
TgeneTERTchr5:19612543chr5:1282739ENST00000296820114914_928524445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:19612543chr5:1282739ENST00000296820114936_1132524445.6666666666667RegionNote=CTE
TgeneTERTchr5:19612543chr5:1282739ENST00000310581116914_9285241133.0RegionNote=Required for oligomerization
TgeneTERTchr5:19612543chr5:1282739ENST00000310581116936_11325241133.0RegionNote=CTE
TgeneTERTchr5:19612543chr5:1282739ENST00000334602115914_9285241070.0RegionNote=Required for oligomerization
TgeneTERTchr5:19612543chr5:1282739ENST00000334602115936_11325241070.0RegionNote=CTE
TgeneTERTchr5:19612543chr5:1282739ENST0000050810418914_928524808.0RegionNote=Required for oligomerization
TgeneTERTchr5:19612543chr5:1282739ENST0000050810418936_1132524808.0RegionNote=CTE

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH18chr5:19612543chr5:1282739ENST00000274170-613269_383270791.0DomainCadherin 3
HgeneCDH18chr5:19612543chr5:1282739ENST00000274170-613384_486270791.0DomainCadherin 4
HgeneCDH18chr5:19612543chr5:1282739ENST00000274170-613487_608270791.0DomainCadherin 5
HgeneCDH18chr5:19612543chr5:1282739ENST00000382275-613269_383270791.0DomainCadherin 3
HgeneCDH18chr5:19612543chr5:1282739ENST00000382275-613384_486270791.0DomainCadherin 4
HgeneCDH18chr5:19612543chr5:1282739ENST00000382275-613487_608270791.0DomainCadherin 5
HgeneCDH18chr5:19612543chr5:1282739ENST00000502796-613269_383270595.6666666666666DomainCadherin 3
HgeneCDH18chr5:19612543chr5:1282739ENST00000502796-613384_486270595.6666666666666DomainCadherin 4
HgeneCDH18chr5:19612543chr5:1282739ENST00000502796-613487_608270595.6666666666666DomainCadherin 5
HgeneCDH18chr5:19612543chr5:1282739ENST00000507958-815269_383270791.0DomainCadherin 3
HgeneCDH18chr5:19612543chr5:1282739ENST00000507958-815384_486270791.0DomainCadherin 4
HgeneCDH18chr5:19612543chr5:1282739ENST00000507958-815487_608270791.0DomainCadherin 5
HgeneCDH18chr5:19612543chr5:1282739ENST00000274170-61354_608270791.0Topological domainExtracellular
HgeneCDH18chr5:19612543chr5:1282739ENST00000274170-613637_790270791.0Topological domainCytoplasmic
HgeneCDH18chr5:19612543chr5:1282739ENST00000382275-61354_608270791.0Topological domainExtracellular
HgeneCDH18chr5:19612543chr5:1282739ENST00000382275-613637_790270791.0Topological domainCytoplasmic
HgeneCDH18chr5:19612543chr5:1282739ENST00000502796-61354_608270595.6666666666666Topological domainExtracellular
HgeneCDH18chr5:19612543chr5:1282739ENST00000502796-613637_790270595.6666666666666Topological domainCytoplasmic
HgeneCDH18chr5:19612543chr5:1282739ENST00000507958-81554_608270791.0Topological domainExtracellular
HgeneCDH18chr5:19612543chr5:1282739ENST00000507958-815637_790270791.0Topological domainCytoplasmic
HgeneCDH18chr5:19612543chr5:1282739ENST00000274170-613609_636270791.0TransmembraneHelical
HgeneCDH18chr5:19612543chr5:1282739ENST00000382275-613609_636270791.0TransmembraneHelical
HgeneCDH18chr5:19612543chr5:1282739ENST00000502796-613609_636270595.6666666666666TransmembraneHelical
HgeneCDH18chr5:19612543chr5:1282739ENST00000507958-815609_636270791.0TransmembraneHelical
TgeneTERTchr5:19612543chr5:1282739ENST00000296820114222_240524445.6666666666667MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:19612543chr5:1282739ENST00000296820114328_333524445.6666666666667MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:19612543chr5:1282739ENST00000310581116222_2405241133.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:19612543chr5:1282739ENST00000310581116328_3335241133.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:19612543chr5:1282739ENST00000334602115222_2405241070.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:19612543chr5:1282739ENST00000334602115328_3335241070.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:19612543chr5:1282739ENST0000050810418222_240524808.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:19612543chr5:1282739ENST0000050810418328_333524808.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:19612543chr5:1282739ENST000002968201141_230524445.6666666666667RegionNote=RNA-interacting domain 1
TgeneTERTchr5:19612543chr5:1282739ENST00000296820114231_324524445.6666666666667RegionNote=Linker
TgeneTERTchr5:19612543chr5:1282739ENST00000296820114301_538524445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:19612543chr5:1282739ENST00000296820114325_550524445.6666666666667RegionNote=RNA-interacting domain 2
TgeneTERTchr5:19612543chr5:1282739ENST00000296820114376_521524445.6666666666667RegionNote=QFP motif
TgeneTERTchr5:19612543chr5:1282739ENST00000296820114397_417524445.6666666666667RegionNote=CP motif
TgeneTERTchr5:19612543chr5:1282739ENST0000029682011458_197524445.6666666666667RegionNote=GQ motif
TgeneTERTchr5:19612543chr5:1282739ENST000003105811161_2305241133.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:19612543chr5:1282739ENST00000310581116231_3245241133.0RegionNote=Linker
TgeneTERTchr5:19612543chr5:1282739ENST00000310581116301_5385241133.0RegionNote=Required for oligomerization
TgeneTERTchr5:19612543chr5:1282739ENST00000310581116325_5505241133.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:19612543chr5:1282739ENST00000310581116376_5215241133.0RegionNote=QFP motif
TgeneTERTchr5:19612543chr5:1282739ENST00000310581116397_4175241133.0RegionNote=CP motif
TgeneTERTchr5:19612543chr5:1282739ENST0000031058111658_1975241133.0RegionNote=GQ motif
TgeneTERTchr5:19612543chr5:1282739ENST000003346021151_2305241070.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:19612543chr5:1282739ENST00000334602115231_3245241070.0RegionNote=Linker
TgeneTERTchr5:19612543chr5:1282739ENST00000334602115301_5385241070.0RegionNote=Required for oligomerization
TgeneTERTchr5:19612543chr5:1282739ENST00000334602115325_5505241070.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:19612543chr5:1282739ENST00000334602115376_5215241070.0RegionNote=QFP motif
TgeneTERTchr5:19612543chr5:1282739ENST00000334602115397_4175241070.0RegionNote=CP motif
TgeneTERTchr5:19612543chr5:1282739ENST0000033460211558_1975241070.0RegionNote=GQ motif
TgeneTERTchr5:19612543chr5:1282739ENST00000508104181_230524808.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:19612543chr5:1282739ENST0000050810418231_324524808.0RegionNote=Linker
TgeneTERTchr5:19612543chr5:1282739ENST0000050810418301_538524808.0RegionNote=Required for oligomerization
TgeneTERTchr5:19612543chr5:1282739ENST0000050810418325_550524808.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:19612543chr5:1282739ENST0000050810418376_521524808.0RegionNote=QFP motif
TgeneTERTchr5:19612543chr5:1282739ENST0000050810418397_417524808.0RegionNote=CP motif
TgeneTERTchr5:19612543chr5:1282739ENST000005081041858_197524808.0RegionNote=GQ motif


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Fusion Gene Sequence for CDH18-TERT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15025_15025_1_CDH18-TERT_CDH18_chr5_19612543_ENST00000274170_TERT_chr5_1282739_ENST00000296820_length(transcript)=3521nt_BP=1323nt
TTTAAGTACTGCAGTCATCTAATGTACTTCACCAGCAGAATCTAAATTCTAGATCCAAGAAAGATTATTGTCAGCTGGCTTTATTCAGGG
TCCAATTCTGAGCCCAGTATCAAGTAATAAAGATTGAGTGGTGTGATAATTAGAGATGCTTCAACCAAAGTTTTCAAAAATGGGAACATA
TTGAACCCTTGGTTCTACAACTACCTTCTTACAACGAAGTTAGTATGCAGTGCTCTCCAAGTCAATAAGGAAAGTGGTTGAAAATGGTTG
CTTGTGTTCAACTACTGTGAAGAGTTGGAATCAGACAACTACGGCTTTGATTTTCCAAGTGGTTCAGAATGTAAATATGATCTGACCTTT
CCCTGATGGACAGTTAAATCATGGACACGCTAAACAATTTACTTTGGACTGTCCTTCCTAAAGATGCTCTGGCTTCTCTCTTGAATGCTC
ACTAAGCTTTCGTAGCTGACAAGGAAAGGAAGGAAAACTGTGAACTGGAAAGTTATCTTACAATGAAAATTACTAGCACATCTTGCATCT
GTCCAGTCCTAGTGTGTCTCTGTTTTGTGCAGAGGTGTTATGGAACTGCTCACCACAGCTCCATCAAGGTGATGAGAAACCAAACCAAAC
ACATTGAAGGTGAAACCGAAGTCCATCATCGTCCCAAAAGGGGATGGGTATGGAATCAGTTCTTTGTTTTAGAAGAACATATGGGACCAG
ATCCTCAGTATGTTGGAAAGCTGCACTCCAATTCTGACAAAGGTGATGGATCTGTCAAGTACATCCTTACTGGAGAGGGTGCTGGGACTA
TATTTATCATTGACGATACCACGGGTGATATCCACTCAACAAAAAGCCTAGACAGAGAGCAGAAGACCCACTATGTGCTTCATGCTCAAG
CTATTGATAGACGTACAAACAAACCTCTTGAGCCTGAATCCGAGTTCATCATCAAAGTGCAAGACATCAATGACAACGCTCCAAAATTCA
CAGATGGACCATACATTGTTACTGTGCCTGAAATGTCAGATATGGGTACCTCTGTTCTACAGGTGACAGCTACTGATGCAGATGACCCTA
CCTATGGAAACAGCGCTCGGGTGGTTTACAGCATTCTCCAAGGACAACCCTACTTCTCCGTCGACCCTAAAACAGGAGTTATTAGAACGG
CCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCTGGGCAAGTTGGAGGGCTTTCAG
GATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAGGGTTGGCTGTGTTCCGGCCGCAGAGC
ACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTGATGAGTGTGTACGTCGTCGAGCTGCTCAGGTCTTTCTTTTATGTCA
CGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAGAGTGTCTGGAGCAAGTTGCAAAGCATTGGAATCAGACAGCACTTGA
AGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAGCATCGGGAAGCCAGGCCCGCCCTGCTGACGTCCAGACTCCGCTTCA
TCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTACGTCGTGGGAGCCAGAACGTTCCGCAGAGAAAAGAGGGCCGAGCGTC
TCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAGCGGGCGCGGCGCCCCGGCCTCCTGGGCGCCTCTGTGCTGGGCCTGG
ACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGGGCCCAGGACCCGCCGCCTGAGCTGTACTTTGTCAAGGTGGATGTGA
CGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTCATCGCCAGCATCATCAAACCCCAGAACACGTACTGCGTGCGTCGGT
ATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCCTTCAAGAGCCACGTCCTACGTCCAGTGCCAGGGGATCCCGCAGGGC
TCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACATGGAGAACAAGCTGTTTGCGGGGATTCGGCGGGACGGGCTGCTCCTG
CGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCACGCGAAAACCTTCCTCAGGACCCTGGTCCGAGGTGTCCCTGAGTAT
GGCTGCGTGGTGAACTTGCGGAAGACAGTGGTGAACTTCCCTGTAGAAGACGAGGCCCTGGGTGGCACGGCTTTTGTTCAGATGCCGGCC
CACGGCCTATTCCCCTGGTGCGGCCTGCTGCTGGATACCCGGACCCTGGAGGTGCAGAGCGACTACTCCAGCTATGCCCGGACCTCCATC
AGAGCCAGTCTCACCTTCAACCGCGGCTTCAAGGCTGGGAGGAACATGCGTCGCAAACTCTTTGGGGTCTTGCGGCTGAAGTGTCACAGC
CTGTTTCTGGATTTGCAGGTGAACAGCCTCCAGACGGTGTGCACCAACATCTACAAGATCCTCCTGCTGCAGGCGTACAGGTTTCACGCA
TGTGTGCTGCAGCTCCCATTTCATCAGCAAGTTTGGAAGAACCCCACATTTTTCCTGCGCGTCATCTCTGACACGGCCTCCCTCTGCTAC
TCCATCCTGAAAGCCAAGAACGCAGGGATGTCGCTGGGGGCCAAGGGCGCCGCCGGCCCTCTGCCCTCCGAGGCCGTGCAGTGGCTGTGC
CACCAAGCATTCCTGCTCAAGCTGACTCGACACCGTGTCACCTACGTGCCACTCCTGGGGTCACTCAGGACAGCCCAGACGCAGCTGAGT
CGGAAGCTCCCGGGGACGACGCTGACTGCCCTGGAGGCCGCAGCCAACCCGGCACTGCCCTCAGACTTCAAGACCATCCTGGACTGATGG
CCACCCGCCCACAGCCAGGCCGAGAGCAGACACCAGCAGCCCTGTCACGCCGGGCTCTACGTCCCAGGGAGGGAGGGGCGGCCCACACCC
AGGCCCGCACCGCTGGGAGTCTGAGGCCTGAGTGAGTGTTTGGCCGAGGCCTGCATGTCCGGCTGAAGGCTGAGTGTCCGGCTGAGGCCT
GAGCGAGTGTCCAGCCAAGGGCTGAGTGTCCAGCACACCTGCCGTCTTCACTTCCCCACAGGCTGGCGCTCGGCTCCACCCCAGGGCCAG
CTTTTCCTCACCAGGAGCCCGGCTTCCACTCCCCACATAGGAATAGTCCATCCCCAGATTCGCCATTGTTCACCCCTCGCCCTGCCCTCC
TTTGCCTTCCACCCCCACCATCCAGGTGGAGACCCTGAGAAGGACCCTGGGAGCTCTGGGAATTTGGAGTGACCAAAGGTGTGCCCTGTA
CACAGGCGAGGACCCTGCACCTGGATGGGGGTCCCTGTGGGTCAAATTGGGGGGAGGTGCTGTGGGAGTAAAATACTGAATATATGAGTT

>15025_15025_1_CDH18-TERT_CDH18_chr5_19612543_ENST00000274170_TERT_chr5_1282739_ENST00000296820_length(amino acids)=559AA_BP=277
MESYLTMKITSTSCICPVLVCLCFVQRCYGTAHHSSIKVMRNQTKHIEGETEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKG
DGSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDM
GTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDN
PPRFPQRVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQ
HREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVR
AQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVLRPVPGDPAGLHPLHAALQPVLRRH

--------------------------------------------------------------
>15025_15025_2_CDH18-TERT_CDH18_chr5_19612543_ENST00000506372_TERT_chr5_1282739_ENST00000296820_length(transcript)=3521nt_BP=1323nt
TTTAAGTACTGCAGTCATCTAATGTACTTCACCAGCAGAATCTAAATTCTAGATCCAAGAAAGATTATTGTCAGCTGGCTTTATTCAGGG
TCCAATTCTGAGCCCAGTATCAAGTAATAAAGATTGAGTGGTGTGATAATTAGAGATGCTTCAACCAAAGTTTTCAAAAATGGGAACATA
TTGAACCCTTGGTTCTACAACTACCTTCTTACAACGAAGTTAGTATGCAGTGCTCTCCAAGTCAATAAGGAAAGTGGTTGAAAATGGTTG
CTTGTGTTCAACTACTGTGAAGAGTTGGAATCAGACAACTACGGCTTTGATTTTCCAAGTGGTTCAGAATGTAAATATGATCTGACCTTT
CCCTGATGGACAGTTAAATCATGGACACGCTAAACAATTTACTTTGGACTGTCCTTCCTAAAGATGCTCTGGCTTCTCTCTTGAATGCTC
ACTAAGCTTTCGTAGCTGACAAGGAAAGGAAGGAAAACTGTGAACTGGAAAGTTATCTTACAATGAAAATTACTAGCACATCTTGCATCT
GTCCAGTCCTAGTGTGTCTCTGTTTTGTGCAGAGGTGTTATGGAACTGCTCACCACAGCTCCATCAAGGTGATGAGAAACCAAACCAAAC
ACATTGAAGGTGAAACCGAAGTCCATCATCGTCCCAAAAGGGGATGGGTATGGAATCAGTTCTTTGTTTTAGAAGAACATATGGGACCAG
ATCCTCAGTATGTTGGAAAGCTGCACTCCAATTCTGACAAAGGTGATGGATCTGTCAAGTACATCCTTACTGGAGAGGGTGCTGGGACTA
TATTTATCATTGACGATACCACGGGTGATATCCACTCAACAAAAAGCCTAGACAGAGAGCAGAAGACCCACTATGTGCTTCATGCTCAAG
CTATTGATAGACGTACAAACAAACCTCTTGAGCCTGAATCCGAGTTCATCATCAAAGTGCAAGACATCAATGACAACGCTCCAAAATTCA
CAGATGGACCATACATTGTTACTGTGCCTGAAATGTCAGATATGGGTACCTCTGTTCTACAGGTGACAGCTACTGATGCAGATGACCCTA
CCTATGGAAACAGCGCTCGGGTGGTTTACAGCATTCTCCAAGGACAACCCTACTTCTCCGTCGACCCTAAAACAGGAGTTATTAGAACGG
CCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGACATGGCTGGGCAAGTTGGAGGGCTTTCAG
GATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAACCCACCACGCTTTCCTCAAAGGGTTGGCTGTGTTCCGGCCGCAGAGC
ACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTGATGAGTGTGTACGTCGTCGAGCTGCTCAGGTCTTTCTTTTATGTCA
CGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAGAGTGTCTGGAGCAAGTTGCAAAGCATTGGAATCAGACAGCACTTGA
AGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAGCATCGGGAAGCCAGGCCCGCCCTGCTGACGTCCAGACTCCGCTTCA
TCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTACGTCGTGGGAGCCAGAACGTTCCGCAGAGAAAAGAGGGCCGAGCGTC
TCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAGCGGGCGCGGCGCCCCGGCCTCCTGGGCGCCTCTGTGCTGGGCCTGG
ACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGGGCCCAGGACCCGCCGCCTGAGCTGTACTTTGTCAAGGTGGATGTGA
CGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTCATCGCCAGCATCATCAAACCCCAGAACACGTACTGCGTGCGTCGGT
ATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCCTTCAAGAGCCACGTCCTACGTCCAGTGCCAGGGGATCCCGCAGGGC
TCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACATGGAGAACAAGCTGTTTGCGGGGATTCGGCGGGACGGGCTGCTCCTG
CGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCACGCGAAAACCTTCCTCAGGACCCTGGTCCGAGGTGTCCCTGAGTAT
GGCTGCGTGGTGAACTTGCGGAAGACAGTGGTGAACTTCCCTGTAGAAGACGAGGCCCTGGGTGGCACGGCTTTTGTTCAGATGCCGGCC
CACGGCCTATTCCCCTGGTGCGGCCTGCTGCTGGATACCCGGACCCTGGAGGTGCAGAGCGACTACTCCAGCTATGCCCGGACCTCCATC
AGAGCCAGTCTCACCTTCAACCGCGGCTTCAAGGCTGGGAGGAACATGCGTCGCAAACTCTTTGGGGTCTTGCGGCTGAAGTGTCACAGC
CTGTTTCTGGATTTGCAGGTGAACAGCCTCCAGACGGTGTGCACCAACATCTACAAGATCCTCCTGCTGCAGGCGTACAGGTTTCACGCA
TGTGTGCTGCAGCTCCCATTTCATCAGCAAGTTTGGAAGAACCCCACATTTTTCCTGCGCGTCATCTCTGACACGGCCTCCCTCTGCTAC
TCCATCCTGAAAGCCAAGAACGCAGGGATGTCGCTGGGGGCCAAGGGCGCCGCCGGCCCTCTGCCCTCCGAGGCCGTGCAGTGGCTGTGC
CACCAAGCATTCCTGCTCAAGCTGACTCGACACCGTGTCACCTACGTGCCACTCCTGGGGTCACTCAGGACAGCCCAGACGCAGCTGAGT
CGGAAGCTCCCGGGGACGACGCTGACTGCCCTGGAGGCCGCAGCCAACCCGGCACTGCCCTCAGACTTCAAGACCATCCTGGACTGATGG
CCACCCGCCCACAGCCAGGCCGAGAGCAGACACCAGCAGCCCTGTCACGCCGGGCTCTACGTCCCAGGGAGGGAGGGGCGGCCCACACCC
AGGCCCGCACCGCTGGGAGTCTGAGGCCTGAGTGAGTGTTTGGCCGAGGCCTGCATGTCCGGCTGAAGGCTGAGTGTCCGGCTGAGGCCT
GAGCGAGTGTCCAGCCAAGGGCTGAGTGTCCAGCACACCTGCCGTCTTCACTTCCCCACAGGCTGGCGCTCGGCTCCACCCCAGGGCCAG
CTTTTCCTCACCAGGAGCCCGGCTTCCACTCCCCACATAGGAATAGTCCATCCCCAGATTCGCCATTGTTCACCCCTCGCCCTGCCCTCC
TTTGCCTTCCACCCCCACCATCCAGGTGGAGACCCTGAGAAGGACCCTGGGAGCTCTGGGAATTTGGAGTGACCAAAGGTGTGCCCTGTA
CACAGGCGAGGACCCTGCACCTGGATGGGGGTCCCTGTGGGTCAAATTGGGGGGAGGTGCTGTGGGAGTAAAATACTGAATATATGAGTT

>15025_15025_2_CDH18-TERT_CDH18_chr5_19612543_ENST00000506372_TERT_chr5_1282739_ENST00000296820_length(amino acids)=559AA_BP=277
MESYLTMKITSTSCICPVLVCLCFVQRCYGTAHHSSIKVMRNQTKHIEGETEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKG
DGSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDM
GTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDN
PPRFPQRVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQ
HREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVR
AQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVLRPVPGDPAGLHPLHAALQPVLRRH

--------------------------------------------------------------
>15025_15025_3_CDH18-TERT_CDH18_chr5_19612543_ENST00000511273_TERT_chr5_1282739_ENST00000296820_length(transcript)=3387nt_BP=1189nt
GGAGCCTGAGTCTGGGCTTTCCGAGGACGGCGAGCAGCTGTGCCCAGAGCTCTGGGAAAGTCCCCTCTCTTTGCTTCTTATAAATTAAGT
TCCTTTCCACCAGTTAGGGCAAGTCCGCCAAGGTTGAAAATGGTTGCTTGTGTTCAACTACTGTGAAGAGTTGGAATCAGACAACTACGG
CTTTGATTTTCCAAGTGGTTCAGAATGTAAATATGATCTGACCTTTCCCTGATGGACAGTTAAATCATGGACACGCTAAACAATTTACTT
TGGACTGTCCTTCCTAAAGATGCTCTGGCTTCTCTCTTGAATGCTCACTAAGCTTTCGTAGCTGACAAGGAAAGGAAGGAAAACTGTGAA
CTGGAAAGTTATCTTACAATGAAAATTACTAGCACATCTTGCATCTGTCCAGTCCTAGTGTGTCTCTGTTTTGTGCAGAGGTGTTATGGA
ACTGCTCACCACAGCTCCATCAAGGTGATGAGAAACCAAACCAAACACATTGAAGGTGAAACCGAAGTCCATCATCGTCCCAAAAGGGGA
TGGGTATGGAATCAGTTCTTTGTTTTAGAAGAACATATGGGACCAGATCCTCAGTATGTTGGAAAGCTGCACTCCAATTCTGACAAAGGT
GATGGATCTGTCAAGTACATCCTTACTGGAGAGGGTGCTGGGACTATATTTATCATTGACGATACCACGGGTGATATCCACTCAACAAAA
AGCCTAGACAGAGAGCAGAAGACCCACTATGTGCTTCATGCTCAAGCTATTGATAGACGTACAAACAAACCTCTTGAGCCTGAATCCGAG
TTCATCATCAAAGTGCAAGACATCAATGACAACGCTCCAAAATTCACAGATGGACCATACATTGTTACTGTGCCTGAAATGTCAGATATG
GGTACCTCTGTTCTACAGGTGACAGCTACTGATGCAGATGACCCTACCTATGGAAACAGCGCTCGGGTGGTTTACAGCATTCTCCAAGGA
CAACCCTACTTCTCCGTCGACCCTAAAACAGGAGTTATTAGAACGGCCTTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTA
GTCATTCAAGCCAAAGACATGGCTGGGCAAGTTGGAGGGCTTTCAGGATCTACAACAGTCAACATCACCTTAACCGATGTCAATGACAAC
CCACCACGCTTTCCTCAAAGGGTTGGCTGTGTTCCGGCCGCAGAGCACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTG
ATGAGTGTGTACGTCGTCGAGCTGCTCAGGTCTTTCTTTTATGTCACGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAG
AGTGTCTGGAGCAAGTTGCAAAGCATTGGAATCAGACAGCACTTGAAGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAG
CATCGGGAAGCCAGGCCCGCCCTGCTGACGTCCAGACTCCGCTTCATCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTAC
GTCGTGGGAGCCAGAACGTTCCGCAGAGAAAAGAGGGCCGAGCGTCTCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAG
CGGGCGCGGCGCCCCGGCCTCCTGGGCGCCTCTGTGCTGGGCCTGGACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGG
GCCCAGGACCCGCCGCCTGAGCTGTACTTTGTCAAGGTGGATGTGACGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTC
ATCGCCAGCATCATCAAACCCCAGAACACGTACTGCGTGCGTCGGTATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCC
TTCAAGAGCCACGTCCTACGTCCAGTGCCAGGGGATCCCGCAGGGCTCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACAT
GGAGAACAAGCTGTTTGCGGGGATTCGGCGGGACGGGCTGCTCCTGCGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCA
CGCGAAAACCTTCCTCAGGACCCTGGTCCGAGGTGTCCCTGAGTATGGCTGCGTGGTGAACTTGCGGAAGACAGTGGTGAACTTCCCTGT
AGAAGACGAGGCCCTGGGTGGCACGGCTTTTGTTCAGATGCCGGCCCACGGCCTATTCCCCTGGTGCGGCCTGCTGCTGGATACCCGGAC
CCTGGAGGTGCAGAGCGACTACTCCAGCTATGCCCGGACCTCCATCAGAGCCAGTCTCACCTTCAACCGCGGCTTCAAGGCTGGGAGGAA
CATGCGTCGCAAACTCTTTGGGGTCTTGCGGCTGAAGTGTCACAGCCTGTTTCTGGATTTGCAGGTGAACAGCCTCCAGACGGTGTGCAC
CAACATCTACAAGATCCTCCTGCTGCAGGCGTACAGGTTTCACGCATGTGTGCTGCAGCTCCCATTTCATCAGCAAGTTTGGAAGAACCC
CACATTTTTCCTGCGCGTCATCTCTGACACGGCCTCCCTCTGCTACTCCATCCTGAAAGCCAAGAACGCAGGGATGTCGCTGGGGGCCAA
GGGCGCCGCCGGCCCTCTGCCCTCCGAGGCCGTGCAGTGGCTGTGCCACCAAGCATTCCTGCTCAAGCTGACTCGACACCGTGTCACCTA
CGTGCCACTCCTGGGGTCACTCAGGACAGCCCAGACGCAGCTGAGTCGGAAGCTCCCGGGGACGACGCTGACTGCCCTGGAGGCCGCAGC
CAACCCGGCACTGCCCTCAGACTTCAAGACCATCCTGGACTGATGGCCACCCGCCCACAGCCAGGCCGAGAGCAGACACCAGCAGCCCTG
TCACGCCGGGCTCTACGTCCCAGGGAGGGAGGGGCGGCCCACACCCAGGCCCGCACCGCTGGGAGTCTGAGGCCTGAGTGAGTGTTTGGC
CGAGGCCTGCATGTCCGGCTGAAGGCTGAGTGTCCGGCTGAGGCCTGAGCGAGTGTCCAGCCAAGGGCTGAGTGTCCAGCACACCTGCCG
TCTTCACTTCCCCACAGGCTGGCGCTCGGCTCCACCCCAGGGCCAGCTTTTCCTCACCAGGAGCCCGGCTTCCACTCCCCACATAGGAAT
AGTCCATCCCCAGATTCGCCATTGTTCACCCCTCGCCCTGCCCTCCTTTGCCTTCCACCCCCACCATCCAGGTGGAGACCCTGAGAAGGA
CCCTGGGAGCTCTGGGAATTTGGAGTGACCAAAGGTGTGCCCTGTACACAGGCGAGGACCCTGCACCTGGATGGGGGTCCCTGTGGGTCA

>15025_15025_3_CDH18-TERT_CDH18_chr5_19612543_ENST00000511273_TERT_chr5_1282739_ENST00000296820_length(amino acids)=559AA_BP=277
MESYLTMKITSTSCICPVLVCLCFVQRCYGTAHHSSIKVMRNQTKHIEGETEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKG
DGSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDM
GTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDN
PPRFPQRVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQ
HREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVR
AQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVLRPVPGDPAGLHPLHAALQPVLRRH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDH18-TERT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDH18-TERT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDH18-TERT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource