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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDH1-CDH1 (FusionGDB2 ID:15031)

Fusion Gene Summary for CDH1-CDH1

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH1-CDH1
Fusion gene ID: 15031
HgeneTgene
Gene symbol

CDH1

CDH1

Gene ID

51343

51343

Gene namefizzy and cell division cycle 20 related 1fizzy and cell division cycle 20 related 1
SynonymsCDC20C|CDH1|FZR|FZR2|HCDH|HCDH1CDC20C|CDH1|FZR|FZR2|HCDH|HCDH1
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionfizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1fizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1
Modification date2020031320200313
UniProtAcc

P12830

Q9H159

Ensembl transtripts involved in fusion geneENST00000562836, ENST00000261769, 
ENST00000422392, 		ENST00000261769, 
ENST00000422392, ENST00000562836, 
Fusion gene scores* DoF score21 X 16 X 8=268819 X 20 X 5=1900
# samples 2923
** MAII scorelog2(29/2688*10)=-3.21240833276383
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/1900*10)=-3.04629365227394
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDH1 [Title/Abstract] AND CDH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDH1(68868970)-CDH1(68868933), # samples:1
CDH1(68847242)-CDH1(68844170), # samples:1
CDH1(68868453)-CDH1(68868806), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDH1

GO:0031145

anaphase-promoting complex-dependent catabolic process

18662541|21596315

HgeneCDH1

GO:0072425

signal transduction involved in G2 DNA damage checkpoint

18662541

HgeneCDH1

GO:1904668

positive regulation of ubiquitin protein ligase activity

11459826

TgeneCDH1

GO:0031145

anaphase-promoting complex-dependent catabolic process

18662541|21596315

TgeneCDH1

GO:0072425

signal transduction involved in G2 DNA damage checkpoint

18662541

TgeneCDH1

GO:1904668

positive regulation of ubiquitin protein ligase activity

11459826


check buttonFusion gene breakpoints across CDH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW843356CDH1chr16

68868970

+CDH1chr16

68868933

-
ChiTaRS5.0N/ABF155173CDH1chr16

68847242

-CDH1chr16

68844170

+
ChiTaRS5.0N/ABF771649CDH1chr16

68868453

-CDH1chr16

68868806

+


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Fusion Gene ORF analysis for CDH1-CDH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000562836ENST00000261769CDH1chr16

68847242

-CDH1chr16

68844170

+
3UTR-3CDSENST00000562836ENST00000422392CDH1chr16

68847242

-CDH1chr16

68844170

+
3UTR-3UTRENST00000261769ENST00000261769CDH1chr16

68868970

+CDH1chr16

68868933

-
3UTR-3UTRENST00000261769ENST00000261769CDH1chr16

68868453

-CDH1chr16

68868806

+
3UTR-3UTRENST00000562836ENST00000562836CDH1chr16

68847242

-CDH1chr16

68844170

+
3UTR-intronENST00000261769ENST00000422392CDH1chr16

68868970

+CDH1chr16

68868933

-
3UTR-intronENST00000261769ENST00000422392CDH1chr16

68868453

-CDH1chr16

68868806

+
3UTR-intronENST00000261769ENST00000562836CDH1chr16

68868970

+CDH1chr16

68868933

-
3UTR-intronENST00000261769ENST00000562836CDH1chr16

68868453

-CDH1chr16

68868806

+
5CDS-3UTRENST00000261769ENST00000562836CDH1chr16

68847242

-CDH1chr16

68844170

+
In-frameENST00000261769ENST00000261769CDH1chr16

68847242

-CDH1chr16

68844170

+
In-frameENST00000261769ENST00000422392CDH1chr16

68847242

-CDH1chr16

68844170

+
intron-3CDSENST00000422392ENST00000261769CDH1chr16

68847242

-CDH1chr16

68844170

+
intron-3CDSENST00000422392ENST00000422392CDH1chr16

68847242

-CDH1chr16

68844170

+
intron-3UTRENST00000422392ENST00000261769CDH1chr16

68868970

+CDH1chr16

68868933

-
intron-3UTRENST00000422392ENST00000261769CDH1chr16

68868453

-CDH1chr16

68868806

+
intron-3UTRENST00000422392ENST00000562836CDH1chr16

68847242

-CDH1chr16

68844170

+
intron-3UTRENST00000562836ENST00000261769CDH1chr16

68868970

+CDH1chr16

68868933

-
intron-3UTRENST00000562836ENST00000261769CDH1chr16

68868453

-CDH1chr16

68868806

+
intron-intronENST00000422392ENST00000422392CDH1chr16

68868970

+CDH1chr16

68868933

-
intron-intronENST00000422392ENST00000422392CDH1chr16

68868453

-CDH1chr16

68868806

+
intron-intronENST00000422392ENST00000562836CDH1chr16

68868970

+CDH1chr16

68868933

-
intron-intronENST00000422392ENST00000562836CDH1chr16

68868453

-CDH1chr16

68868806

+
intron-intronENST00000562836ENST00000422392CDH1chr16

68868970

+CDH1chr16

68868933

-
intron-intronENST00000562836ENST00000422392CDH1chr16

68868453

-CDH1chr16

68868806

+
intron-intronENST00000562836ENST00000562836CDH1chr16

68868970

+CDH1chr16

68868933

-
intron-intronENST00000562836ENST00000562836CDH1chr16

68868453

-CDH1chr16

68868806

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CDH1-CDH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDH1-CDH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:68868970/chr16:68868933)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH1

P12830

CDH1

Q9H159

FUNCTION: Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}.FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDH1chr16:68847242chr16:68844170ENST00000261769016838_8510883.0Compositional biasNote=Ser-rich
TgeneCDH1chr16:68847242chr16:68844170ENST00000261769016155_2620883.0DomainCadherin 1
TgeneCDH1chr16:68847242chr16:68844170ENST00000261769016263_3750883.0DomainCadherin 2
TgeneCDH1chr16:68847242chr16:68844170ENST00000261769016376_4860883.0DomainCadherin 3
TgeneCDH1chr16:68847242chr16:68844170ENST00000261769016487_5930883.0DomainCadherin 4
TgeneCDH1chr16:68847242chr16:68844170ENST00000261769016594_6970883.0DomainCadherin 5
TgeneCDH1chr16:68847242chr16:68844170ENST00000261769016758_7690883.0RegionNote=Required for binding CTNND1 and PSEN1
TgeneCDH1chr16:68847242chr16:68844170ENST00000261769016811_8820883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
TgeneCDH1chr16:68847242chr16:68844170ENST00000261769016155_7090883.0Topological domainExtracellular
TgeneCDH1chr16:68847242chr16:68844170ENST00000261769016731_8820883.0Topological domainCytoplasmic
TgeneCDH1chr16:68847242chr16:68844170ENST00000261769016710_7300883.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH1chr16:68847242chr16:68844170ENST00000261769-116838_8510883.0Compositional biasNote=Ser-rich
HgeneCDH1chr16:68847242chr16:68844170ENST00000261769-116155_2620883.0DomainCadherin 1
HgeneCDH1chr16:68847242chr16:68844170ENST00000261769-116263_3750883.0DomainCadherin 2
HgeneCDH1chr16:68847242chr16:68844170ENST00000261769-116376_4860883.0DomainCadherin 3
HgeneCDH1chr16:68847242chr16:68844170ENST00000261769-116487_5930883.0DomainCadherin 4
HgeneCDH1chr16:68847242chr16:68844170ENST00000261769-116594_6970883.0DomainCadherin 5
HgeneCDH1chr16:68847242chr16:68844170ENST00000261769-116758_7690883.0RegionNote=Required for binding CTNND1 and PSEN1
HgeneCDH1chr16:68847242chr16:68844170ENST00000261769-116811_8820883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
HgeneCDH1chr16:68847242chr16:68844170ENST00000261769-116155_7090883.0Topological domainExtracellular
HgeneCDH1chr16:68847242chr16:68844170ENST00000261769-116731_8820883.0Topological domainCytoplasmic
HgeneCDH1chr16:68847242chr16:68844170ENST00000261769-116710_7300883.0TransmembraneHelical


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Fusion Gene Sequence for CDH1-CDH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CDH1-CDH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDH1-CDH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDH1-CDH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource