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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CDH3-CHKA (FusionGDB2 ID:15072)

Fusion Gene Summary for CDH3-CHKA

Fusion gene summary

Fusion gene information	Fusion gene name: CDH3-CHKA
	Fusion gene ID: 15072
		Hgene	Tgene
	Gene symbol	CDH3	CHKA
	Gene ID	1013	1119
	Gene name	cadherin 15	choline kinase alpha
	Synonyms	CDH14\|CDH3\|CDHM\|MCAD\|MRD3	CHK\|CK\|CKI\|EK
	Cytomap	16q24.3	11q13.2
	Type of gene	protein-coding	protein-coding
	Description	cadherin-15cadherin 15, type 1, M-cadherin (myotubule)cadherin-14cadherin-3muscle-cadherin	choline kinase alphaCHETK-alphaethanolamine kinase
	Modification date	20200313	20200313
	UniProtAcc	P22223	P35790
	Ensembl transtripts involved in fusion gene	ENST00000264012, ENST00000429102, ENST00000581171, ENST00000569117,	ENST00000356135, ENST00000533728, ENST00000265689,
Fusion gene scores	* DoF score	12 X 8 X 6=576	11 X 10 X 7=770
	# samples	15	13
	** MAII score	log2(15/576*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/770*10)=-2.56634682255381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CDH3 [Title/Abstract] AND CHKA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CDH3(68718727)-CHKA(67836404), # samples:4
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CHKA	GO:0006646	phosphatidylethanolamine biosynthetic process	19915674
Tgene	CHKA	GO:0006656	phosphatidylcholine biosynthetic process	19915674

Fusion gene breakpoints across CDH3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CHKA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-DK-A6AV-01A	CDH3	chr16	68718727	-	CHKA	chr11	67836404	-
ChimerDB4	BLCA	TCGA-DK-A6AV-01A	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
ChimerDB4	BLCA	TCGA-DK-A6AV	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-

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Fusion Gene ORF analysis for CDH3-CHKA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000264012	ENST00000356135	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
5CDS-intron	ENST00000264012	ENST00000533728	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
5CDS-intron	ENST00000429102	ENST00000356135	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
5CDS-intron	ENST00000429102	ENST00000533728	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
5CDS-intron	ENST00000581171	ENST00000356135	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
5CDS-intron	ENST00000581171	ENST00000533728	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
In-frame	ENST00000264012	ENST00000265689	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
In-frame	ENST00000429102	ENST00000265689	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
In-frame	ENST00000581171	ENST00000265689	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
intron-3CDS	ENST00000569117	ENST00000265689	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
intron-intron	ENST00000569117	ENST00000356135	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-
intron-intron	ENST00000569117	ENST00000533728	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264012	CDH3	chr16	68718727	+	ENST00000265689	CHKA	chr11	67836404	-	3602	1968	346	2472	708
ENST00000429102	CDH3	chr16	68718727	+	ENST00000265689	CHKA	chr11	67836404	-	3445	1811	189	2315	708
ENST00000581171	CDH3	chr16	68718727	+	ENST00000265689	CHKA	chr11	67836404	-	3022	1388	54	1892	612

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264012	ENST00000265689	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-	0.000862223	0.99913776
ENST00000429102	ENST00000265689	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-	0.000902238	0.9990978
ENST00000581171	ENST00000265689	CDH3	chr16	68718727	+	CHKA	chr11	67836404	-	0.001012625	0.9989874

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Fusion Genomic Features for CDH3-CHKA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDH3-CHKA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:68718727/chr11:67836404)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDH3 P22223	CHKA P35790
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	FUNCTION: Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. {ECO:0000269\|PubMed:19915674}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000264012

108_215

474

830.0

Domain

Cadherin 1

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000264012

216_328

474

830.0

Domain

Cadherin 2

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000264012

329_440

474

830.0

Domain

Cadherin 3

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000429102

108_215

474

785.0

Domain

Cadherin 1

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000429102

216_328

474

785.0

Domain

Cadherin 2

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000429102

329_440

474

785.0

Domain

Cadherin 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000264012

785_800

474

830.0

Compositional bias

Note=Ser-rich

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000429102

785_800

474

785.0

Compositional bias

Note=Ser-rich

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000264012

441_546

474

830.0

Domain

Cadherin 4

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000264012

547_650

474

830.0

Domain

Cadherin 5

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000429102

441_546

474

785.0

Domain

Cadherin 4

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000429102

547_650

474

785.0

Domain

Cadherin 5

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000264012

108_654

474

830.0

Topological domain

Extracellular

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000264012

678_829

474

830.0

Topological domain

Cytoplasmic

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000429102

108_654

474

785.0

Topological domain

Extracellular

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000429102

678_829

474

785.0

Topological domain

Cytoplasmic

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000264012

655_677

474

830.0

Transmembrane

Helical

Hgene

CDH3

chr16:68718727

chr11:67836404

ENST00000429102

655_677

474

785.0

Transmembrane

Helical

Tgene

CHKA

chr16:68718727

chr11:67836404

ENST00000265689

50_85

289

458.0

Compositional bias

Note=Pro-rich

Tgene

CHKA

chr16:68718727

chr11:67836404

ENST00000356135

50_85

271

440.0

Compositional bias

Note=Pro-rich

Tgene

CHKA

chr16:68718727

chr11:67836404

ENST00000265689

117_123

289

458.0

Nucleotide binding

Note=ATP

Tgene

CHKA

chr16:68718727

chr11:67836404

ENST00000265689

207_213

289

458.0

Nucleotide binding

Note=ATP

Tgene

CHKA

chr16:68718727

chr11:67836404

ENST00000356135

117_123

271

440.0

Nucleotide binding

Note=ATP

Tgene

CHKA

chr16:68718727

chr11:67836404

ENST00000356135

207_213

271

440.0

Nucleotide binding

Note=ATP

Tgene

CHKA

chr16:68718727

chr11:67836404

ENST00000265689

119_121

289

458.0

Region

Note=Substrate binding

Tgene

CHKA

chr16:68718727

chr11:67836404

ENST00000356135

119_121

271

440.0

Region

Note=Substrate binding

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Fusion Gene Sequence for CDH3-CHKA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>15072_15072_1_CDH3-CHKA_CDH3_chr16_68718727_ENST00000264012_CHKA_chr11_67836404_ENST00000265689_length(transcript)=3602nt_BP=1968nt
GGCTGGCACGGGAGGTGGAGAAAGAGGCTTGGGCGGCCCCGCTGTAGCCGCGTGTGGGAGGACGCACGGGCCTGCTTCAAAGCTTTGGGA
TAACAGCGCCTCCGGGGGATAATGAATGCGGAGCCTCCGTTTTCAGTCGACTTCAGATGTGTCTCCACTTTTTTCCGCTGTAGCCGCAAG
GCAAGGAAACATTTCTCTTCCCGTACTGAGGAGGCTGAGGAGTGCACTGGGTGTTCTTTTCTCCTCTAACCCAGAACTGCGAGACAGAGG
CTGAGTCCCTGTAAAGAACAGCTCCAGAAAAGCCAGGAGAGCGCAGGAGGGCATCCGGGAGGCCAGGAGGGGTTCGCTGGGGCCTCAACC
GCACCCACATCGGTCCCACCTGCGAGGGGGCGGGACCTCGTGGCGCTGGACCAATCAGCACCCACCTGCGCTCACCTGGCCTCCTCCCGC
TGGCTCCCGGGGGCTGCGGTGCTCAAAGGGGCAAGAGCTGAGCGGAACACCGGCCCGCCGTCGCGGCAGCTGCTTCACCCCTCTCTCTGC
AGCCATGGGGCTCCCTCGTGGACCTCTCGCGTCTCTCCTCCTTCTCCAGGTTTGCTGGCTGCAGTGCGCGGCCTCCGAGCCGTGCCGGGC
GGTCTTCAGGGAGGCTGAAGTGACCTTGGAGGCGGGAGGCGCGGAGCAGGAGCCCGGCCAGGCGCTGGGGAAAGTATTCATGGGCTGCCC
TGGGCAAGAGCCAGCTCTGTTTAGCACTGATAATGATGACTTCACTGTGCGGAATGGCGAGACAGTCCAGGAAAGAAGGTCACTGAAGGA
AAGGAATCCATTGAAGATCTTCCCATCCAAACGTATCTTACGAAGACACAAGAGAGATTGGGTGGTTGCTCCAATATCTGTCCCTGAAAA
TGGCAAGGGTCCCTTCCCCCAGAGACTGAATCAGCTCAAGTCTAATAAAGATAGAGACACCAAGATTTTCTACAGCATCACGGGGCCGGG
GGCAGACAGCCCCCCTGAGGGTGTCTTCGCTGTAGAGAAGGAGACAGGCTGGTTGTTGTTGAATAAGCCACTGGACCGGGAGGAGATTGC
CAAGTATGAGCTCTTTGGCCACGCTGTGTCAGAGAATGGTGCCTCAGTGGAGGACCCCATGAACATCTCCATCATCGTGACCGACCAGAA
TGACCACAAGCCCAAGTTTACCCAGGACACCTTCCGAGGGAGTGTCTTAGAGGGAGTCCTACCAGGTACTTCTGTGATGCAGGTGACAGC
CACGGATGAGGATGATGCCATCTACACCTACAATGGGGTGGTTGCTTACTCCATCCATAGCCAAGAACCAAAGGACCCACACGACCTCAT
GTTCACCATTCACCGGAGCACAGGCACCATCAGCGTCATCTCCAGTGGCCTGGACCGGGAAAAAGTCCCTGAGTACACACTGACCATCCA
GGCCACAGACATGGATGGGGACGGCTCCACCACCACGGCAGTGGCAGTAGTGGAGATCCTTGATGCCAATGACAATGCTCCCATGTTTGA
CCCCCAGAAGTACGAGGCCCATGTGCCTGAGAATGCAGTGGGCCATGAGGTGCAGAGGCTGACGGTCACTGATCTGGACGCCCCCAACTC
ACCAGCGTGGCGTGCCACCTACCTTATCATGGGCGGTGACGACGGGGACCATTTTACCATCACCACCCACCCTGAGAGCAACCAGGGCAT
CCTGACAACCAGGAAGGGTTTGGATTTTGAGGCCAAAAACCAGCACACCCTGTACGTTGAAGTGACCAACGAGGCCCCTTTTGTGCTGAA
GCTCCCAACCTCCACAGCCACCATAGTGGTCCACGTGGAGGATGTGAATGAGGCACCTGTGTTTGTCCCACCCTCCAAAGTCGTTGAGGT
CCAGGAGGGCATCCCCACTGGGGAGCCTGTGTGTGTCTACACTGCAGAAGACCCTGACAAGGAGAATCAAAAGATCAGATCATTGCTTGA
ATCTACTCCATCTCCAGTTGTATTTTGTCATAATGACTGTCAAGAAGGTAATATCTTGTTGCTGGAAGGCCGAGAGAATTCTGAAAAACA
GAAACTGATGCTCATTGATTTCGAATACAGCAGTTACAATTACAGGGGATTCGACATTGGAAATCACTTCTGTGAGTGGATGTATGATTA
TAGCTATGAAAAATACCCTTTTTTCAGAGCAAACATCCGGAAGTATCCCACCAAGAAACAACAGCTCCATTTTATTTCCAGTTACTTGCC
TGCATTCCAAAATGACTTTGAAAACCTCAGTACTGAAGAAAAATCCATTATAAAAGAAGAAATGTTGCTTGAAGTTAATAGGTTTGCCCT
TGCATCTCATTTCCTCTGGGGACTGTGGTCCATTGTACAAGCCAAGATTTCATCTATTGAATTTGGGTACATGGACTACGCCCAAGCAAG
GTTTGATGCCTATTTCCACCAGAAGAGGAAGCTTGGGGTGTGACTGTGGGGAGGACTCCATCCACCTCATCACTGGACTGCATGGGGAGG
CAGCAGAGCGGGGTCCCCTCTGTGCTTCGACTACTGCTCCTGTGGCAGGAGGCTTTGGGTGGCTCACTACTGAACACATGTGTATGATAC
TAAAGACGGTATTAAAATGGAGCGACGTTTATTTCATCTCTTGTTTACGATTTCACTAGGACTCAGAAACGAGATCGGGAAGCAGAAATA
TAGTGCAATAGTGCAACATCTCTGAATCCTTTTAATCTAGAGAAGGCATTTCATATTTGGGGGCTAAGGTTTCCAGTCAGATGAGGCAAA
CAGCAAGAGTAAGCAGTGTTACTTGCAGGTACTTTGGTTAATGTTGATTTAAATTTTCATGAATGTGCTGGTGAACACTGTGACCAGGCT
TTTGTAGATGGCGATGTGTTATAGACGGTGCTCACTCCCAAGGGACAGCAAGTGAGCAGAGATGTACTGCAAAGTCGCCAGTCACTGCTG
CAAGGTGGCCTCTGCCTGGGGCCTCCAGAAGCTGCTCCTTTACCCTCTTGGTCCCATGGCTGAAGCTGGAGCAGCGGATTGCTCTGGAGC
AGCCAAGGCCGCCAGCGTGTGGAGCAGAGCTCTCCCCTCCTGCTGGGCGTGTGTGACACTGATGAGTTTCACTGTACTGCATGTGACTTC
TCCCCTGCCCTTCCTCCTGATGGAGTGTGCAGACAGCCATGCGTGGCCACGGGGGCAGTGTGAGGACCTCCCTGTCTCCCGGCTCCCCTC
CCAGGGGAGCCAGCTGCTTGACCTAGCTCTTTGGGCCTCTCCTGCCCTCTGCTCTGCCTGGAGTGTCGGATCCTGTGAGTAGGCTGGGCC
TCCCCTGGGCAGGGTTCTCCAAGGGCCCGGTTTCCCGGCCCTTACCTTTCCTGATGCCCCTGACATCATCATTCTTGTGGGAGACAGCAG
CCTGTATGTGGTGTGGGGCGTGGATCGAGTGTAGCTGTGAAATCCATATATATGAAATGTCCTGCGGGATACAGTCTTAGCTGACTTTTT
TTTACTCTGAACTCTTATTTGAATTGTTTTTTGTGCATATATTTCTGCTACCACAGAGATTGTACTATACAAATAAAAAAATAAAAACCC

>15072_15072_1_CDH3-CHKA_CDH3_chr16_68718727_ENST00000264012_CHKA_chr11_67836404_ENST00000265689_length(amino acids)=708AA_BP=540
MGPQPHPHRSHLRGGGTSWRWTNQHPPALTWPPPAGSRGLRCSKGQELSGTPARRRGSCFTPLSAAMGLPRGPLASLLLLQVCWLQCAAS
EPCRAVFREAEVTLEAGGAEQEPGQALGKVFMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPI
SVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISII
VTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEY
TLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPE
SNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKI
RSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFI

--------------------------------------------------------------
>15072_15072_2_CDH3-CHKA_CDH3_chr16_68718727_ENST00000429102_CHKA_chr11_67836404_ENST00000265689_length(transcript)=3445nt_BP=1811nt
CTTTTTTCCGCTGTAGCCGCAAGGCAAGGAAACATTTCTCTTCCCGTACTGAGGAGGCTGAGGAGTGCACTGGGTGTTCTTTTCTCCTCT
AACCCAGAACTGCGAGACAGAGGCTGAGTCCCTGTAAAGAACAGCTCCAGAAAAGCCAGGAGAGCGCAGGAGGGCATCCGGGAGGCCAGG
AGGGGTTCGCTGGGGCCTCAACCGCACCCACATCGGTCCCACCTGCGAGGGGGCGGGACCTCGTGGCGCTGGACCAATCAGCACCCACCT
GCGCTCACCTGGCCTCCTCCCGCTGGCTCCCGGGGGCTGCGGTGCTCAAAGGGGCAAGAGCTGAGCGGAACACCGGCCCGCCGTCGCGGC
AGCTGCTTCACCCCTCTCTCTGCAGCCATGGGGCTCCCTCGTGGACCTCTCGCGTCTCTCCTCCTTCTCCAGGTTTGCTGGCTGCAGTGC
GCGGCCTCCGAGCCGTGCCGGGCGGTCTTCAGGGAGGCTGAAGTGACCTTGGAGGCGGGAGGCGCGGAGCAGGAGCCCGGCCAGGCGCTG
GGGAAAGTATTCATGGGCTGCCCTGGGCAAGAGCCAGCTCTGTTTAGCACTGATAATGATGACTTCACTGTGCGGAATGGCGAGACAGTC
CAGGAAAGAAGGTCACTGAAGGAAAGGAATCCATTGAAGATCTTCCCATCCAAACGTATCTTACGAAGACACAAGAGAGATTGGGTGGTT
GCTCCAATATCTGTCCCTGAAAATGGCAAGGGTCCCTTCCCCCAGAGACTGAATCAGCTCAAGTCTAATAAAGATAGAGACACCAAGATT
TTCTACAGCATCACGGGGCCGGGGGCAGACAGCCCCCCTGAGGGTGTCTTCGCTGTAGAGAAGGAGACAGGCTGGTTGTTGTTGAATAAG
CCACTGGACCGGGAGGAGATTGCCAAGTATGAGCTCTTTGGCCACGCTGTGTCAGAGAATGGTGCCTCAGTGGAGGACCCCATGAACATC
TCCATCATCGTGACCGACCAGAATGACCACAAGCCCAAGTTTACCCAGGACACCTTCCGAGGGAGTGTCTTAGAGGGAGTCCTACCAGGT
ACTTCTGTGATGCAGGTGACAGCCACGGATGAGGATGATGCCATCTACACCTACAATGGGGTGGTTGCTTACTCCATCCATAGCCAAGAA
CCAAAGGACCCACACGACCTCATGTTCACCATTCACCGGAGCACAGGCACCATCAGCGTCATCTCCAGTGGCCTGGACCGGGAAAAAGTC
CCTGAGTACACACTGACCATCCAGGCCACAGACATGGATGGGGACGGCTCCACCACCACGGCAGTGGCAGTAGTGGAGATCCTTGATGCC
AATGACAATGCTCCCATGTTTGACCCCCAGAAGTACGAGGCCCATGTGCCTGAGAATGCAGTGGGCCATGAGGTGCAGAGGCTGACGGTC
ACTGATCTGGACGCCCCCAACTCACCAGCGTGGCGTGCCACCTACCTTATCATGGGCGGTGACGACGGGGACCATTTTACCATCACCACC
CACCCTGAGAGCAACCAGGGCATCCTGACAACCAGGAAGGGTTTGGATTTTGAGGCCAAAAACCAGCACACCCTGTACGTTGAAGTGACC
AACGAGGCCCCTTTTGTGCTGAAGCTCCCAACCTCCACAGCCACCATAGTGGTCCACGTGGAGGATGTGAATGAGGCACCTGTGTTTGTC
CCACCCTCCAAAGTCGTTGAGGTCCAGGAGGGCATCCCCACTGGGGAGCCTGTGTGTGTCTACACTGCAGAAGACCCTGACAAGGAGAAT
CAAAAGATCAGATCATTGCTTGAATCTACTCCATCTCCAGTTGTATTTTGTCATAATGACTGTCAAGAAGGTAATATCTTGTTGCTGGAA
GGCCGAGAGAATTCTGAAAAACAGAAACTGATGCTCATTGATTTCGAATACAGCAGTTACAATTACAGGGGATTCGACATTGGAAATCAC
TTCTGTGAGTGGATGTATGATTATAGCTATGAAAAATACCCTTTTTTCAGAGCAAACATCCGGAAGTATCCCACCAAGAAACAACAGCTC
CATTTTATTTCCAGTTACTTGCCTGCATTCCAAAATGACTTTGAAAACCTCAGTACTGAAGAAAAATCCATTATAAAAGAAGAAATGTTG
CTTGAAGTTAATAGGTTTGCCCTTGCATCTCATTTCCTCTGGGGACTGTGGTCCATTGTACAAGCCAAGATTTCATCTATTGAATTTGGG
TACATGGACTACGCCCAAGCAAGGTTTGATGCCTATTTCCACCAGAAGAGGAAGCTTGGGGTGTGACTGTGGGGAGGACTCCATCCACCT
CATCACTGGACTGCATGGGGAGGCAGCAGAGCGGGGTCCCCTCTGTGCTTCGACTACTGCTCCTGTGGCAGGAGGCTTTGGGTGGCTCAC
TACTGAACACATGTGTATGATACTAAAGACGGTATTAAAATGGAGCGACGTTTATTTCATCTCTTGTTTACGATTTCACTAGGACTCAGA
AACGAGATCGGGAAGCAGAAATATAGTGCAATAGTGCAACATCTCTGAATCCTTTTAATCTAGAGAAGGCATTTCATATTTGGGGGCTAA
GGTTTCCAGTCAGATGAGGCAAACAGCAAGAGTAAGCAGTGTTACTTGCAGGTACTTTGGTTAATGTTGATTTAAATTTTCATGAATGTG
CTGGTGAACACTGTGACCAGGCTTTTGTAGATGGCGATGTGTTATAGACGGTGCTCACTCCCAAGGGACAGCAAGTGAGCAGAGATGTAC
TGCAAAGTCGCCAGTCACTGCTGCAAGGTGGCCTCTGCCTGGGGCCTCCAGAAGCTGCTCCTTTACCCTCTTGGTCCCATGGCTGAAGCT
GGAGCAGCGGATTGCTCTGGAGCAGCCAAGGCCGCCAGCGTGTGGAGCAGAGCTCTCCCCTCCTGCTGGGCGTGTGTGACACTGATGAGT
TTCACTGTACTGCATGTGACTTCTCCCCTGCCCTTCCTCCTGATGGAGTGTGCAGACAGCCATGCGTGGCCACGGGGGCAGTGTGAGGAC
CTCCCTGTCTCCCGGCTCCCCTCCCAGGGGAGCCAGCTGCTTGACCTAGCTCTTTGGGCCTCTCCTGCCCTCTGCTCTGCCTGGAGTGTC
GGATCCTGTGAGTAGGCTGGGCCTCCCCTGGGCAGGGTTCTCCAAGGGCCCGGTTTCCCGGCCCTTACCTTTCCTGATGCCCCTGACATC
ATCATTCTTGTGGGAGACAGCAGCCTGTATGTGGTGTGGGGCGTGGATCGAGTGTAGCTGTGAAATCCATATATATGAAATGTCCTGCGG
GATACAGTCTTAGCTGACTTTTTTTTACTCTGAACTCTTATTTGAATTGTTTTTTGTGCATATATTTCTGCTACCACAGAGATTGTACTA

>15072_15072_2_CDH3-CHKA_CDH3_chr16_68718727_ENST00000429102_CHKA_chr11_67836404_ENST00000265689_length(amino acids)=708AA_BP=540
MGPQPHPHRSHLRGGGTSWRWTNQHPPALTWPPPAGSRGLRCSKGQELSGTPARRRGSCFTPLSAAMGLPRGPLASLLLLQVCWLQCAAS
EPCRAVFREAEVTLEAGGAEQEPGQALGKVFMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPI
SVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISII
VTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEY
TLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPE
SNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKI
RSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFI

--------------------------------------------------------------
>15072_15072_3_CDH3-CHKA_CDH3_chr16_68718727_ENST00000581171_CHKA_chr11_67836404_ENST00000265689_length(transcript)=3022nt_BP=1388nt
GCGGTGCTCAAAGGGGCAAGAGCTGAGCGGAACACCGGCCCGCCGTCGCGGCAGCTGCTTCACCCCTCTCTCTGCAGCCATGGGGCTCCC
TCGTGGACCTCTCGCGTCTCTCCTCCTTCTCCAGTATTCATGGGCTGCCCTGGGCAAGAGCCAGCTCTGTTTAGCACTGATAATGATGAC
TTCACTGTGCGGAATGGCGAGACAGTCCAGGAAAGAAGGTCACTGAAGGAAAGGAATCCATTGAAGATCTTCCCATCCAAACGTATCTTA
CGAAGACACAAGAGAGATTGGGTGGTTGCTCCAATATCTGTCCCTGAAAATGGCAAGGGTCCCTTCCCCCAGAGACTGAATCAGCTCAAG
TCTAATAAAGATAGAGACACCAAGATTTTCTACAGCATCACGGGGCCGGGGGCAGACAGCCCCCCTGAGGGTGTCTTCGCTGTAGAGAAG
GAGACAGGCTGGTTGTTGTTGAATAAGCCACTGGACCGGGAGGAGATTGCCAAGTATGAGCTCTTTGGCCACGCTGTGTCAGAGAATGGT
GCCTCAGTGGAGGACCCCATGAACATCTCCATCATCGTGACCGACCAGAATGACCACAAGCCCAAGTTTACCCAGGACACCTTCCGAGGG
AGTGTCTTAGAGGGAGTCCTACCAGGTACTTCTGTGATGCAGGTGACAGCCACGGATGAGGATGATGCCATCTACACCTACAATGGGGTG
GTTGCTTACTCCATCCATAGCCAAGAACCAAAGGACCCACACGACCTCATGTTCACCATTCACCGGAGCACAGGCACCATCAGCGTCATC
TCCAGTGGCCTGGACCGGGAAAAAGTCCCTGAGTACACACTGACCATCCAGGCCACAGACATGGATGGGGACGGCTCCACCACCACGGCA
GTGGCAGTAGTGGAGATCCTTGATGCCAATGACAATGCTCCCATGTTTGACCCCCAGAAGTACGAGGCCCATGTGCCTGAGAATGCAGTG
GGCCATGAGGTGCAGAGGCTGACGGTCACTGATCTGGACGCCCCCAACTCACCAGCGTGGCGTGCCACCTACCTTATCATGGGCGGTGAC
GACGGGGACCATTTTACCATCACCACCCACCCTGAGAGCAACCAGGGCATCCTGACAACCAGGAAGGGTTTGGATTTTGAGGCCAAAAAC
CAGCACACCCTGTACGTTGAAGTGACCAACGAGGCCCCTTTTGTGCTGAAGCTCCCAACCTCCACAGCCACCATAGTGGTCCACGTGGAG
GATGTGAATGAGGCACCTGTGTTTGTCCCACCCTCCAAAGTCGTTGAGGTCCAGGAGGGCATCCCCACTGGGGAGCCTGTGTGTGTCTAC
ACTGCAGAAGACCCTGACAAGGAGAATCAAAAGATCAGATCATTGCTTGAATCTACTCCATCTCCAGTTGTATTTTGTCATAATGACTGT
CAAGAAGGTAATATCTTGTTGCTGGAAGGCCGAGAGAATTCTGAAAAACAGAAACTGATGCTCATTGATTTCGAATACAGCAGTTACAAT
TACAGGGGATTCGACATTGGAAATCACTTCTGTGAGTGGATGTATGATTATAGCTATGAAAAATACCCTTTTTTCAGAGCAAACATCCGG
AAGTATCCCACCAAGAAACAACAGCTCCATTTTATTTCCAGTTACTTGCCTGCATTCCAAAATGACTTTGAAAACCTCAGTACTGAAGAA
AAATCCATTATAAAAGAAGAAATGTTGCTTGAAGTTAATAGGTTTGCCCTTGCATCTCATTTCCTCTGGGGACTGTGGTCCATTGTACAA
GCCAAGATTTCATCTATTGAATTTGGGTACATGGACTACGCCCAAGCAAGGTTTGATGCCTATTTCCACCAGAAGAGGAAGCTTGGGGTG
TGACTGTGGGGAGGACTCCATCCACCTCATCACTGGACTGCATGGGGAGGCAGCAGAGCGGGGTCCCCTCTGTGCTTCGACTACTGCTCC
TGTGGCAGGAGGCTTTGGGTGGCTCACTACTGAACACATGTGTATGATACTAAAGACGGTATTAAAATGGAGCGACGTTTATTTCATCTC
TTGTTTACGATTTCACTAGGACTCAGAAACGAGATCGGGAAGCAGAAATATAGTGCAATAGTGCAACATCTCTGAATCCTTTTAATCTAG
AGAAGGCATTTCATATTTGGGGGCTAAGGTTTCCAGTCAGATGAGGCAAACAGCAAGAGTAAGCAGTGTTACTTGCAGGTACTTTGGTTA
ATGTTGATTTAAATTTTCATGAATGTGCTGGTGAACACTGTGACCAGGCTTTTGTAGATGGCGATGTGTTATAGACGGTGCTCACTCCCA
AGGGACAGCAAGTGAGCAGAGATGTACTGCAAAGTCGCCAGTCACTGCTGCAAGGTGGCCTCTGCCTGGGGCCTCCAGAAGCTGCTCCTT
TACCCTCTTGGTCCCATGGCTGAAGCTGGAGCAGCGGATTGCTCTGGAGCAGCCAAGGCCGCCAGCGTGTGGAGCAGAGCTCTCCCCTCC
TGCTGGGCGTGTGTGACACTGATGAGTTTCACTGTACTGCATGTGACTTCTCCCCTGCCCTTCCTCCTGATGGAGTGTGCAGACAGCCAT
GCGTGGCCACGGGGGCAGTGTGAGGACCTCCCTGTCTCCCGGCTCCCCTCCCAGGGGAGCCAGCTGCTTGACCTAGCTCTTTGGGCCTCT
CCTGCCCTCTGCTCTGCCTGGAGTGTCGGATCCTGTGAGTAGGCTGGGCCTCCCCTGGGCAGGGTTCTCCAAGGGCCCGGTTTCCCGGCC
CTTACCTTTCCTGATGCCCCTGACATCATCATTCTTGTGGGAGACAGCAGCCTGTATGTGGTGTGGGGCGTGGATCGAGTGTAGCTGTGA
AATCCATATATATGAAATGTCCTGCGGGATACAGTCTTAGCTGACTTTTTTTTACTCTGAACTCTTATTTGAATTGTTTTTTGTGCATAT

>15072_15072_3_CDH3-CHKA_CDH3_chr16_68718727_ENST00000581171_CHKA_chr11_67836404_ENST00000265689_length(amino acids)=612AA_BP=444
MLHPSLCSHGAPSWTSRVSPPSPVFMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENG
KGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQND
HKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQA
TDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGIL
TTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKIRSLLES
TPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CDH3-CHKA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CDH3-CHKA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CDH3-CHKA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source