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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDH8-RFX1 (FusionGDB2 ID:15097)

Fusion Gene Summary for CDH8-RFX1

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH8-RFX1
Fusion gene ID: 15097
HgeneTgene
Gene symbol

CDH8

RFX1

Gene ID

1006

5989

Gene namecadherin 8regulatory factor X1
SynonymsNbla04261EFC|RFX
Cytomap

16q21

19p13.12

Type of geneprotein-codingprotein-coding
Descriptioncadherin-8cadherin 8, type 2MHC class II regulatory factor RFX1MHC class II regulatory factor RFXenhancer factor Cregulatory factor X, 1 (influences HLA class II expression)trans-acting regulatory factor 1transcription factor RFX1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000299345, ENST00000577390, 
ENST00000577730, ENST00000584337, 
ENST00000580044, 
ENST00000586913, 
ENST00000254325, 
Fusion gene scores* DoF score4 X 4 X 2=325 X 4 X 4=80
# samples 44
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDH8 [Title/Abstract] AND RFX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDH8(61935083)-RFX1(14083939), # samples:3
Anticipated loss of major functional domain due to fusion event.CDH8-RFX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CDH8-RFX1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CDH8-RFX1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CDH8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RFX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DS-A5RQ-01ACDH8chr16

61935083

-RFX1chr19

14083939

-


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Fusion Gene ORF analysis for CDH8-RFX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000299345ENST00000586913CDH8chr16

61935083

-RFX1chr19

14083939

-
5CDS-intronENST00000577390ENST00000586913CDH8chr16

61935083

-RFX1chr19

14083939

-
5CDS-intronENST00000577730ENST00000586913CDH8chr16

61935083

-RFX1chr19

14083939

-
5CDS-intronENST00000584337ENST00000586913CDH8chr16

61935083

-RFX1chr19

14083939

-
Frame-shiftENST00000577730ENST00000254325CDH8chr16

61935083

-RFX1chr19

14083939

-
In-frameENST00000299345ENST00000254325CDH8chr16

61935083

-RFX1chr19

14083939

-
In-frameENST00000577390ENST00000254325CDH8chr16

61935083

-RFX1chr19

14083939

-
In-frameENST00000584337ENST00000254325CDH8chr16

61935083

-RFX1chr19

14083939

-
intron-3CDSENST00000580044ENST00000254325CDH8chr16

61935083

-RFX1chr19

14083939

-
intron-intronENST00000580044ENST00000586913CDH8chr16

61935083

-RFX1chr19

14083939

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000299345CDH8chr1661935083-ENST00000254325RFX1chr1914083939-4670150215363512658
ENST00000577390CDH8chr1661935083-ENST00000254325RFX1chr1914083939-4670150215363512658
ENST00000584337CDH8chr1661935083-ENST00000254325RFX1chr1914083939-4237106911033079658

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000299345ENST00000254325CDH8chr1661935083-RFX1chr1914083939-0.0069569760.99304307
ENST00000577390ENST00000254325CDH8chr1661935083-RFX1chr1914083939-0.0069569760.99304307
ENST00000584337ENST00000254325CDH8chr1661935083-RFX1chr1914083939-0.0071837590.9928162

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Fusion Genomic Features for CDH8-RFX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDH8-RFX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:61935083/chr19:14083939)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH8chr16:61935083chr19:14083939ENST00000577390-31262_167182800.0DomainCadherin 1
TgeneRFX1chr16:61935083chr19:14083939ENST00000254325721381_411309980.0Compositional biasNote=Gly-rich
TgeneRFX1chr16:61935083chr19:14083939ENST00000254325721920_936309980.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneRFX1chr16:61935083chr19:14083939ENST00000254325721438_513309980.0DNA bindingRFX-type winged-helix
TgeneRFX1chr16:61935083chr19:14083939ENST00000254325721744_979309980.0RegionNote=Necessary for dimerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH8chr16:61935083chr19:14083939ENST00000577390-312168_276182800.0DomainCadherin 2
HgeneCDH8chr16:61935083chr19:14083939ENST00000577390-312277_391182800.0DomainCadherin 3
HgeneCDH8chr16:61935083chr19:14083939ENST00000577390-312392_494182800.0DomainCadherin 4
HgeneCDH8chr16:61935083chr19:14083939ENST00000577390-312495_616182800.0DomainCadherin 5
HgeneCDH8chr16:61935083chr19:14083939ENST00000577390-31262_621182800.0Topological domainExtracellular
HgeneCDH8chr16:61935083chr19:14083939ENST00000577390-312643_799182800.0Topological domainCytoplasmic
HgeneCDH8chr16:61935083chr19:14083939ENST00000577390-312622_642182800.0TransmembraneHelical


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Fusion Gene Sequence for CDH8-RFX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15097_15097_1_CDH8-RFX1_CDH8_chr16_61935083_ENST00000299345_RFX1_chr19_14083939_ENST00000254325_length(transcript)=4670nt_BP=1502nt
AACATAACGCCAGCCCCAGAGCTCAGGTGAGACCTCTAGAGAGAAAGCTCGCAGGTACCTCATCCGCATGCTGTTATTATCTGCCAGCCC
ACTTATCCAGGAGCTCGGTCCTCAGCGGGCTGCGCGCACCGCGCGGAAGGGCGCATCTTCACCTCGTGGCTCTGGCGGCAGAGACGCGCG
GGGCTTGCTCGGGAGCGAGGAGCGAAAAGTTGTGCGCCCACTTGGGTAGGGGGAAAGAGAGCGATCGAGCCAGCGCGGGAGAGCGAAGGG
GGAAGGCGGGGAGGGGGCGGGGAGGGGGGACTGCTTACATGAATTTCCAAGTGGTAGACCTGCCTCTGCGCTCTGCCCAATGAGATCCGT
CAGGGGAGGCACCCGGCTCACTTTTCCACATCACTTCACAGTTACATTTGGCAGGCAGGCGGGCTCGCACGCCGGAGCGCTCAGCCCAGA
ATTAGTGGATTTATTTGGAATCTCCCTGCCTCCTCCAAGCTCCGCCGCCGCCGCCGGCTTGTGCATAGACGGTAGCGTCAAGACACCAGC
TGCACTTTGGGTTGCGGACACCCAGAGCCCAGCGCGCCCGCCCTGCGTCTCCGCACCAAGCCCTGTAGCTCCGAGAGGCATGAACGGAAT
CCGGAGGCGCCTGCCTAGCGAGCGAGGACCGGTCGGCGCTTGCCGCCCTCGGGAGCTAACCCCGAGCACCTCCAGCCATTTGTGAACCTG
GAGGCTTGACATTCGCCAGCGCAGGGCCCCACAAGAGAAATTTCAATGAAAAGAAAAGCCAATGGATTGTGGTCTTAGAAAAGCTGCTTA
GATGATGTCTGTTTCCCGTGCTATAGACACGTGGCAGAGCTGTAAGTAAATGCTCGGCACTGCATGATGAATTGGATGGCTGCAGACCGG
AGACAAAAAAAATAATTGTCTCATTTTCGTGGTGATTTGCTTAACTGGTGGGACCATGCCAGAACGGCTAGCGGAAATGCTCTTGGATCT
CTGGACTCCATTAATAATATTATGGATTACTCTTCCCCCTTGCATTTACATGGCTCCGATGAATCAGTCTCAAGTTTTAATGAGTGGATC
CCCTTTGGAACTAAACAGTCTGGGTGAAGAACAGCGAATTTTGAACCGCTCCAAAAGAGGCTGGGTTTGGAATCAAATGTTTGTCCTGGA
AGAGTTTTCTGGACCTGAACCGATTCTTGTTGGCCGGCTACACACAGACCTGGATCCTGGGAGCAAAAAAATCAAGTATATCCTATCAGG
TGATGGAGCTGGGACCATATTTCAAATAAATGATGTAACTGGAGATATCCATGCTATAAAAAGACTTGACCGGGAGGAAAAGGCTGAGTA
TACCCTAACAGCTCAAGCAGTGGACTGGGAGACAAGCAAACCTCTGGAGCCTCCTTCTGAATTTATTATTAAAGTTCAAGACATCAATGA
CAATGCACCAGAGTTTCTTAATGGACCCTATCATGCTACTGTGCCAGAAATGTCCATTTTGGCCGTTCCAGCACCTACTCCTATCCCGAG
ACGCCGCTGTACACGCAGACGGCAAGCACCAGCTACTACGAGGCCGCAGGCACGGCCACCCAGGTCAGCACCCCCGCCACCTCCCAGGCG
GTGGCCAGCAGTGGCTCCATGCCCATGTACGTGTCCGGCAGCCAGGTCGTCGCCAGCTCCACCAGCACTGGGGCTGGGGCCAGCAACAGC
AGCGGAGGTGGTGGCAGTGGTGGTGGCGGCGGCGGCGGGGGAGGCGGTGGCGGGGGTGGCAGTGGCAGCACCGGAGGCGGCGGCAGCGGA
GCAGGCACCTACGTGATCCAAGGCGGCTACATGCTGGGCAGTGCCAGCCAGTCTTACTCTCACACCACCCGTGCCTCGCCAGCCACGGTC
CAGTGGCTCCTGGACAACTATGAGACGGCTGAGGGCGTGAGTCTGCCACGGAGCACCCTCTACTGCCACTACTTACTGCACTGCCAGGAG
CAGAAGCTGGAGCCCGTCAACGCCGCCTCCTTCGGCAAGCTCATCCGCTCCGTCTTCATGGGCCTGCGAACCCGCCGTCTGGGCACCAGG
GGCAACTCCAAGTACCACTACTATGGCCTGCGCATCAAGGCCAGCTCACCCCTGCTGCGGCTGATGGAGGACCAGCAGCACATGGCCATG
CGGGGCCAGCCCTTCTCGCAGAAGCAGAGGCTCAAGCCCATCCAGAAGATGGAAGGCATGACCAACGGCGTGGCGGTGGGGCAGCAGCCG
AGCACGGGGCTGTCGGACATCAGCGCCCAGGTGCAGCAGTACCAGCAATTTTTGGATGCCTCTCGGAGCCTCCCTGACTTCACAGAGCTC
GACCTCCAGGGCAAGGTGCTGCCTGAGGGCGTCGGGCCCGGGGACATCAAAGCCTTCCAGGTCCTGTACCGGGAACACTGTGAGGCCATT
GTCGACGTCATGGTGAACCTGCAGTTCACCCTGGTGGAGACGCTGTGGAAGACCTTCTGGAGGTACAACCTCAGCCAGCCCAGTGAGGCG
CCACCGCTGGCTGTACATGACGAGGCCGAGAAGCGACTGCCCAAAGCCATCCTGGTGCTCCTCTCCAAGTTCGAGCCCGTGCTCCAATGG
ACCAAGCACTGTGACAACGTGCTGTACCAGGGCCTGGTGGAAATCCTCATTCCCGACGTGCTGCGGCCCATCCCCAGTGCCTTGACCCAA
GCGATCCGGAACTTTGCCAAGAGCCTGGAGAGCTGGCTCACCCACGCCATGGTCAACATCCCCGAGGAGATGCTGCGGGTGAAGGTGGCC
GCGGCTGGCGCCTTCGCGCAGACACTGCGGCGCTACACGTCGCTCAACCACCTGGCGCAGGCGGCGCGCGCTGTGCTGCAGAACACCGCA
CAGATCAACCAGATGCTGAGCGACCTCAACCGCGTGGACTTCGCCAACGTGCAGGAGCAGGCCTCGTGGGTGTGCCGCTGCGAGGACCGC
GTGGTGCAGCGGCTGGAGCAGGACTTCAAGGTGACGCTGCAGCAGCAGAACTCGCTGGAGCAGTGGGCGGCCTGGCTGGACGGCGTGGTG
AGCCAGGTGCTCAAGCCCTACCAGGGCAGCGCCGGCTTCCCCAAGGCCGCCAAGCTCTTCCTCCTCAAGTGGTCCTTCTACAGCTCCATG
GTGATCCGGGACCTGACCCTGCGCAGCGCCGCCAGCTTCGGTTCCTTCCACCTCATCCGGCTGCTCTACGACGAGTACATGTACTACCTG
ATCGAGCACCGCGTAGCCCAGGCCAAGGGCGAGACCCCCATCGCCGTCATGGGCGAGTTCGCCAATCTGGCCACCTCCCTGAACCCCCTG
GACCCCGACAAAGACGAGGAGGAAGAAGAGGAGGAGGAGAGCGAGGACGAGCTGCCGCAGGACATCTCACTGGCGGCTGGCGGCGAGTCA
CCCGCGCTGGGCCCGGAGACCCTGGAGCCGCCGGCCAAGCTGGCGCGGACTGACGCGCGCGGCCTCTTCGTGCAGGCGCTGCCCTCCAGC
TAAGCCCTTGGCCTCCCCGCCCCACCCGCCCCCGCCACCCCTCCACGCCAGGGTCCCTCAAAGCTTCTGTGGCTTCGTGGTCACTGCTCC
AGCCTCAGCCAGGGCAGGGAGGGGGACTCCGAGACAGGGAAGACCGGGGCCCTCCTCCCTTATGGGGCCGGCACAATCAGTGGGCTGGGC
GGAGCCGCAGCTGCAAACTCTGACACAAAAGACGTGCCTTAAGGAACCCGCCGCGTGCCCAGGTGCCCCGCGGGGCATCCAGCTCGGCCC
CTTGGCCGCCCCCCTCCCAGGCCCCAGCGTCTTCTCCCCAGCCCCGTCCTCCCACCACCCCAGGGGGCAGGCAGGCAGGCCCCCTCCCGT
GCGAAACTGTTAACTTATTCAGCTCGCTGGCTTTGCACAGCCTGTCCTGGGCCCAGCCCTGAGCCCCGGGCCGGCGCAGGTGGGCGTCAC
CTGGGGACTCCCCACTGTCAGCAGCAGCCCCGGGACACCCTACCCCCAGCAACCCCACTGCTTCCCCTTCTTGGTATTAAGTGCAATTAA
AGCCGTGGGTGTCGCATCTTCTCCAGCGCTGGGCCCTCCCTTGCCCCCAAGCTCAAGAAGGGGGCACTGCCCGGCCCGGCTGTGAGGAGG
GCGGCAGGGGGCACGGCCTCCAGCTTCCAAAGAGCAGCGAGCCGCGGAGCCGGGGAGTGCCCACAGACCCCAGCCCCCGCGCCCCCGCCC
TCCGCCGCTGGTTTGTAATGGAACCTTTTCTGTGCCCCTATCTTCCCGGAGACCACGCTTCTCCTCCGTGCCGTGCGACCCCCACCCCAT
GACTATTGTGCGATTCGTGAGCGCCGCCCGAGCGGAGTTGGTAACTTGTTGGGTTTTTTTCCAACCATCATGGCCTTATCTGTTCCAGTT
TTCTCAGTGTTTTCAGCCTGTGAGATAGATGTTTATGGCAAGAAAAAGGAAAAAAAAATGGAAATCTGACCTATTGTATAAAAATCACTA
TTTTGTGTGCTCCGCGTGCTATAGCTTTTGGGGCGGCCCTGCCCAGTCCCCGTGCCCACGGGGCTCCCTCTCCCGGTGGTGAAAGTGTCC

>15097_15097_1_CDH8-RFX1_CDH8_chr16_61935083_ENST00000299345_RFX1_chr19_14083939_ENST00000254325_length(amino acids)=658AA_BP=43
MYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPMYVSGSQVVASSTSTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAG
TYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGN
SKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDL
QGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLLSKFEPVLQWTK
HCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQI
NQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFLLKWSFYSSMVI
RDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPA

--------------------------------------------------------------
>15097_15097_2_CDH8-RFX1_CDH8_chr16_61935083_ENST00000577390_RFX1_chr19_14083939_ENST00000254325_length(transcript)=4670nt_BP=1502nt
AACATAACGCCAGCCCCAGAGCTCAGGTGAGACCTCTAGAGAGAAAGCTCGCAGGTACCTCATCCGCATGCTGTTATTATCTGCCAGCCC
ACTTATCCAGGAGCTCGGTCCTCAGCGGGCTGCGCGCACCGCGCGGAAGGGCGCATCTTCACCTCGTGGCTCTGGCGGCAGAGACGCGCG
GGGCTTGCTCGGGAGCGAGGAGCGAAAAGTTGTGCGCCCACTTGGGTAGGGGGAAAGAGAGCGATCGAGCCAGCGCGGGAGAGCGAAGGG
GGAAGGCGGGGAGGGGGCGGGGAGGGGGGACTGCTTACATGAATTTCCAAGTGGTAGACCTGCCTCTGCGCTCTGCCCAATGAGATCCGT
CAGGGGAGGCACCCGGCTCACTTTTCCACATCACTTCACAGTTACATTTGGCAGGCAGGCGGGCTCGCACGCCGGAGCGCTCAGCCCAGA
ATTAGTGGATTTATTTGGAATCTCCCTGCCTCCTCCAAGCTCCGCCGCCGCCGCCGGCTTGTGCATAGACGGTAGCGTCAAGACACCAGC
TGCACTTTGGGTTGCGGACACCCAGAGCCCAGCGCGCCCGCCCTGCGTCTCCGCACCAAGCCCTGTAGCTCCGAGAGGCATGAACGGAAT
CCGGAGGCGCCTGCCTAGCGAGCGAGGACCGGTCGGCGCTTGCCGCCCTCGGGAGCTAACCCCGAGCACCTCCAGCCATTTGTGAACCTG
GAGGCTTGACATTCGCCAGCGCAGGGCCCCACAAGAGAAATTTCAATGAAAAGAAAAGCCAATGGATTGTGGTCTTAGAAAAGCTGCTTA
GATGATGTCTGTTTCCCGTGCTATAGACACGTGGCAGAGCTGTAAGTAAATGCTCGGCACTGCATGATGAATTGGATGGCTGCAGACCGG
AGACAAAAAAAATAATTGTCTCATTTTCGTGGTGATTTGCTTAACTGGTGGGACCATGCCAGAACGGCTAGCGGAAATGCTCTTGGATCT
CTGGACTCCATTAATAATATTATGGATTACTCTTCCCCCTTGCATTTACATGGCTCCGATGAATCAGTCTCAAGTTTTAATGAGTGGATC
CCCTTTGGAACTAAACAGTCTGGGTGAAGAACAGCGAATTTTGAACCGCTCCAAAAGAGGCTGGGTTTGGAATCAAATGTTTGTCCTGGA
AGAGTTTTCTGGACCTGAACCGATTCTTGTTGGCCGGCTACACACAGACCTGGATCCTGGGAGCAAAAAAATCAAGTATATCCTATCAGG
TGATGGAGCTGGGACCATATTTCAAATAAATGATGTAACTGGAGATATCCATGCTATAAAAAGACTTGACCGGGAGGAAAAGGCTGAGTA
TACCCTAACAGCTCAAGCAGTGGACTGGGAGACAAGCAAACCTCTGGAGCCTCCTTCTGAATTTATTATTAAAGTTCAAGACATCAATGA
CAATGCACCAGAGTTTCTTAATGGACCCTATCATGCTACTGTGCCAGAAATGTCCATTTTGGCCGTTCCAGCACCTACTCCTATCCCGAG
ACGCCGCTGTACACGCAGACGGCAAGCACCAGCTACTACGAGGCCGCAGGCACGGCCACCCAGGTCAGCACCCCCGCCACCTCCCAGGCG
GTGGCCAGCAGTGGCTCCATGCCCATGTACGTGTCCGGCAGCCAGGTCGTCGCCAGCTCCACCAGCACTGGGGCTGGGGCCAGCAACAGC
AGCGGAGGTGGTGGCAGTGGTGGTGGCGGCGGCGGCGGGGGAGGCGGTGGCGGGGGTGGCAGTGGCAGCACCGGAGGCGGCGGCAGCGGA
GCAGGCACCTACGTGATCCAAGGCGGCTACATGCTGGGCAGTGCCAGCCAGTCTTACTCTCACACCACCCGTGCCTCGCCAGCCACGGTC
CAGTGGCTCCTGGACAACTATGAGACGGCTGAGGGCGTGAGTCTGCCACGGAGCACCCTCTACTGCCACTACTTACTGCACTGCCAGGAG
CAGAAGCTGGAGCCCGTCAACGCCGCCTCCTTCGGCAAGCTCATCCGCTCCGTCTTCATGGGCCTGCGAACCCGCCGTCTGGGCACCAGG
GGCAACTCCAAGTACCACTACTATGGCCTGCGCATCAAGGCCAGCTCACCCCTGCTGCGGCTGATGGAGGACCAGCAGCACATGGCCATG
CGGGGCCAGCCCTTCTCGCAGAAGCAGAGGCTCAAGCCCATCCAGAAGATGGAAGGCATGACCAACGGCGTGGCGGTGGGGCAGCAGCCG
AGCACGGGGCTGTCGGACATCAGCGCCCAGGTGCAGCAGTACCAGCAATTTTTGGATGCCTCTCGGAGCCTCCCTGACTTCACAGAGCTC
GACCTCCAGGGCAAGGTGCTGCCTGAGGGCGTCGGGCCCGGGGACATCAAAGCCTTCCAGGTCCTGTACCGGGAACACTGTGAGGCCATT
GTCGACGTCATGGTGAACCTGCAGTTCACCCTGGTGGAGACGCTGTGGAAGACCTTCTGGAGGTACAACCTCAGCCAGCCCAGTGAGGCG
CCACCGCTGGCTGTACATGACGAGGCCGAGAAGCGACTGCCCAAAGCCATCCTGGTGCTCCTCTCCAAGTTCGAGCCCGTGCTCCAATGG
ACCAAGCACTGTGACAACGTGCTGTACCAGGGCCTGGTGGAAATCCTCATTCCCGACGTGCTGCGGCCCATCCCCAGTGCCTTGACCCAA
GCGATCCGGAACTTTGCCAAGAGCCTGGAGAGCTGGCTCACCCACGCCATGGTCAACATCCCCGAGGAGATGCTGCGGGTGAAGGTGGCC
GCGGCTGGCGCCTTCGCGCAGACACTGCGGCGCTACACGTCGCTCAACCACCTGGCGCAGGCGGCGCGCGCTGTGCTGCAGAACACCGCA
CAGATCAACCAGATGCTGAGCGACCTCAACCGCGTGGACTTCGCCAACGTGCAGGAGCAGGCCTCGTGGGTGTGCCGCTGCGAGGACCGC
GTGGTGCAGCGGCTGGAGCAGGACTTCAAGGTGACGCTGCAGCAGCAGAACTCGCTGGAGCAGTGGGCGGCCTGGCTGGACGGCGTGGTG
AGCCAGGTGCTCAAGCCCTACCAGGGCAGCGCCGGCTTCCCCAAGGCCGCCAAGCTCTTCCTCCTCAAGTGGTCCTTCTACAGCTCCATG
GTGATCCGGGACCTGACCCTGCGCAGCGCCGCCAGCTTCGGTTCCTTCCACCTCATCCGGCTGCTCTACGACGAGTACATGTACTACCTG
ATCGAGCACCGCGTAGCCCAGGCCAAGGGCGAGACCCCCATCGCCGTCATGGGCGAGTTCGCCAATCTGGCCACCTCCCTGAACCCCCTG
GACCCCGACAAAGACGAGGAGGAAGAAGAGGAGGAGGAGAGCGAGGACGAGCTGCCGCAGGACATCTCACTGGCGGCTGGCGGCGAGTCA
CCCGCGCTGGGCCCGGAGACCCTGGAGCCGCCGGCCAAGCTGGCGCGGACTGACGCGCGCGGCCTCTTCGTGCAGGCGCTGCCCTCCAGC
TAAGCCCTTGGCCTCCCCGCCCCACCCGCCCCCGCCACCCCTCCACGCCAGGGTCCCTCAAAGCTTCTGTGGCTTCGTGGTCACTGCTCC
AGCCTCAGCCAGGGCAGGGAGGGGGACTCCGAGACAGGGAAGACCGGGGCCCTCCTCCCTTATGGGGCCGGCACAATCAGTGGGCTGGGC
GGAGCCGCAGCTGCAAACTCTGACACAAAAGACGTGCCTTAAGGAACCCGCCGCGTGCCCAGGTGCCCCGCGGGGCATCCAGCTCGGCCC
CTTGGCCGCCCCCCTCCCAGGCCCCAGCGTCTTCTCCCCAGCCCCGTCCTCCCACCACCCCAGGGGGCAGGCAGGCAGGCCCCCTCCCGT
GCGAAACTGTTAACTTATTCAGCTCGCTGGCTTTGCACAGCCTGTCCTGGGCCCAGCCCTGAGCCCCGGGCCGGCGCAGGTGGGCGTCAC
CTGGGGACTCCCCACTGTCAGCAGCAGCCCCGGGACACCCTACCCCCAGCAACCCCACTGCTTCCCCTTCTTGGTATTAAGTGCAATTAA
AGCCGTGGGTGTCGCATCTTCTCCAGCGCTGGGCCCTCCCTTGCCCCCAAGCTCAAGAAGGGGGCACTGCCCGGCCCGGCTGTGAGGAGG
GCGGCAGGGGGCACGGCCTCCAGCTTCCAAAGAGCAGCGAGCCGCGGAGCCGGGGAGTGCCCACAGACCCCAGCCCCCGCGCCCCCGCCC
TCCGCCGCTGGTTTGTAATGGAACCTTTTCTGTGCCCCTATCTTCCCGGAGACCACGCTTCTCCTCCGTGCCGTGCGACCCCCACCCCAT
GACTATTGTGCGATTCGTGAGCGCCGCCCGAGCGGAGTTGGTAACTTGTTGGGTTTTTTTCCAACCATCATGGCCTTATCTGTTCCAGTT
TTCTCAGTGTTTTCAGCCTGTGAGATAGATGTTTATGGCAAGAAAAAGGAAAAAAAAATGGAAATCTGACCTATTGTATAAAAATCACTA
TTTTGTGTGCTCCGCGTGCTATAGCTTTTGGGGCGGCCCTGCCCAGTCCCCGTGCCCACGGGGCTCCCTCTCCCGGTGGTGAAAGTGTCC

>15097_15097_2_CDH8-RFX1_CDH8_chr16_61935083_ENST00000577390_RFX1_chr19_14083939_ENST00000254325_length(amino acids)=658AA_BP=43
MYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPMYVSGSQVVASSTSTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAG
TYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGN
SKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDL
QGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLLSKFEPVLQWTK
HCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQI
NQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFLLKWSFYSSMVI
RDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPA

--------------------------------------------------------------
>15097_15097_3_CDH8-RFX1_CDH8_chr16_61935083_ENST00000584337_RFX1_chr19_14083939_ENST00000254325_length(transcript)=4237nt_BP=1069nt
GGAGCGCTCAGCCCAGAATTAGTGGATTTATTTGGAATCTCCCTGCCTCCTCCAAGCTCCGCCGCCGCCGCCGGCTTGTGCATAGACGGT
AGCGTCAAGACACCAGCTGCACTTTGGGTTGCGGACACCCAGAGCCCAGCGCGCCCGCCCTGCGTCTCCGCACCAAGCCCTGTAGCTCCG
AGAGGCATGAACGGAATCCGGAGGCGCCTGCCTAGCGAGCGAGGACCGGTCGGCGCTTGCCGCCCTCGGGAGCTAACCCCGAGCACCTCC
AGCCATTTGTGAACCTGGAGGCTTGACATTCGCCAGCGCAGGGCCCCACAAGAGAAATTTCAATGAAAAGAAAAGCCAATGGATTGTGGT
CTTAGAAAAGCTGCTTAGATGATGTCTGTTTCCCGTGCTATAGACACGTGGCAGAGCTGTAAGTAAATGCTCGGCACTGCATGATGAATT
GGATGGCTGCAGACCGGAGACAAAAAAAATAATTGTCTCATTTTCGTGGTGATTTGCTTAACTGGTGGGACCATGCCAGAACGGCTAGCG
GAAATGCTCTTGGATCTCTGGACTCCATTAATAATATTATGGATTACTCTTCCCCCTTGCATTTACATGGCTCCGATGAATCAGTCTCAA
GTTTTAATGAGTGGATCCCCTTTGGAACTAAACAGTCTGGGTGAAGAACAGCGAATTTTGAACCGCTCCAAAAGAGGCTGGGTTTGGAAT
CAAATGTTTGTCCTGGAAGAGTTTTCTGGACCTGAACCGATTCTTGTTGGCCGGCTACACACAGACCTGGATCCTGGGAGCAAAAAAATC
AAGTATATCCTATCAGGTGATGGAGCTGGGACCATATTTCAAATAAATGATGTAACTGGAGATATCCATGCTATAAAAAGACTTGACCGG
GAGGAAAAGGCTGAGTATACCCTAACAGCTCAAGCAGTGGACTGGGAGACAAGCAAACCTCTGGAGCCTCCTTCTGAATTTATTATTAAA
GTTCAAGACATCAATGACAATGCACCAGAGTTTCTTAATGGACCCTATCATGCTACTGTGCCAGAAATGTCCATTTTGGCCGTTCCAGCA
CCTACTCCTATCCCGAGACGCCGCTGTACACGCAGACGGCAAGCACCAGCTACTACGAGGCCGCAGGCACGGCCACCCAGGTCAGCACCC
CCGCCACCTCCCAGGCGGTGGCCAGCAGTGGCTCCATGCCCATGTACGTGTCCGGCAGCCAGGTCGTCGCCAGCTCCACCAGCACTGGGG
CTGGGGCCAGCAACAGCAGCGGAGGTGGTGGCAGTGGTGGTGGCGGCGGCGGCGGGGGAGGCGGTGGCGGGGGTGGCAGTGGCAGCACCG
GAGGCGGCGGCAGCGGAGCAGGCACCTACGTGATCCAAGGCGGCTACATGCTGGGCAGTGCCAGCCAGTCTTACTCTCACACCACCCGTG
CCTCGCCAGCCACGGTCCAGTGGCTCCTGGACAACTATGAGACGGCTGAGGGCGTGAGTCTGCCACGGAGCACCCTCTACTGCCACTACT
TACTGCACTGCCAGGAGCAGAAGCTGGAGCCCGTCAACGCCGCCTCCTTCGGCAAGCTCATCCGCTCCGTCTTCATGGGCCTGCGAACCC
GCCGTCTGGGCACCAGGGGCAACTCCAAGTACCACTACTATGGCCTGCGCATCAAGGCCAGCTCACCCCTGCTGCGGCTGATGGAGGACC
AGCAGCACATGGCCATGCGGGGCCAGCCCTTCTCGCAGAAGCAGAGGCTCAAGCCCATCCAGAAGATGGAAGGCATGACCAACGGCGTGG
CGGTGGGGCAGCAGCCGAGCACGGGGCTGTCGGACATCAGCGCCCAGGTGCAGCAGTACCAGCAATTTTTGGATGCCTCTCGGAGCCTCC
CTGACTTCACAGAGCTCGACCTCCAGGGCAAGGTGCTGCCTGAGGGCGTCGGGCCCGGGGACATCAAAGCCTTCCAGGTCCTGTACCGGG
AACACTGTGAGGCCATTGTCGACGTCATGGTGAACCTGCAGTTCACCCTGGTGGAGACGCTGTGGAAGACCTTCTGGAGGTACAACCTCA
GCCAGCCCAGTGAGGCGCCACCGCTGGCTGTACATGACGAGGCCGAGAAGCGACTGCCCAAAGCCATCCTGGTGCTCCTCTCCAAGTTCG
AGCCCGTGCTCCAATGGACCAAGCACTGTGACAACGTGCTGTACCAGGGCCTGGTGGAAATCCTCATTCCCGACGTGCTGCGGCCCATCC
CCAGTGCCTTGACCCAAGCGATCCGGAACTTTGCCAAGAGCCTGGAGAGCTGGCTCACCCACGCCATGGTCAACATCCCCGAGGAGATGC
TGCGGGTGAAGGTGGCCGCGGCTGGCGCCTTCGCGCAGACACTGCGGCGCTACACGTCGCTCAACCACCTGGCGCAGGCGGCGCGCGCTG
TGCTGCAGAACACCGCACAGATCAACCAGATGCTGAGCGACCTCAACCGCGTGGACTTCGCCAACGTGCAGGAGCAGGCCTCGTGGGTGT
GCCGCTGCGAGGACCGCGTGGTGCAGCGGCTGGAGCAGGACTTCAAGGTGACGCTGCAGCAGCAGAACTCGCTGGAGCAGTGGGCGGCCT
GGCTGGACGGCGTGGTGAGCCAGGTGCTCAAGCCCTACCAGGGCAGCGCCGGCTTCCCCAAGGCCGCCAAGCTCTTCCTCCTCAAGTGGT
CCTTCTACAGCTCCATGGTGATCCGGGACCTGACCCTGCGCAGCGCCGCCAGCTTCGGTTCCTTCCACCTCATCCGGCTGCTCTACGACG
AGTACATGTACTACCTGATCGAGCACCGCGTAGCCCAGGCCAAGGGCGAGACCCCCATCGCCGTCATGGGCGAGTTCGCCAATCTGGCCA
CCTCCCTGAACCCCCTGGACCCCGACAAAGACGAGGAGGAAGAAGAGGAGGAGGAGAGCGAGGACGAGCTGCCGCAGGACATCTCACTGG
CGGCTGGCGGCGAGTCACCCGCGCTGGGCCCGGAGACCCTGGAGCCGCCGGCCAAGCTGGCGCGGACTGACGCGCGCGGCCTCTTCGTGC
AGGCGCTGCCCTCCAGCTAAGCCCTTGGCCTCCCCGCCCCACCCGCCCCCGCCACCCCTCCACGCCAGGGTCCCTCAAAGCTTCTGTGGC
TTCGTGGTCACTGCTCCAGCCTCAGCCAGGGCAGGGAGGGGGACTCCGAGACAGGGAAGACCGGGGCCCTCCTCCCTTATGGGGCCGGCA
CAATCAGTGGGCTGGGCGGAGCCGCAGCTGCAAACTCTGACACAAAAGACGTGCCTTAAGGAACCCGCCGCGTGCCCAGGTGCCCCGCGG
GGCATCCAGCTCGGCCCCTTGGCCGCCCCCCTCCCAGGCCCCAGCGTCTTCTCCCCAGCCCCGTCCTCCCACCACCCCAGGGGGCAGGCA
GGCAGGCCCCCTCCCGTGCGAAACTGTTAACTTATTCAGCTCGCTGGCTTTGCACAGCCTGTCCTGGGCCCAGCCCTGAGCCCCGGGCCG
GCGCAGGTGGGCGTCACCTGGGGACTCCCCACTGTCAGCAGCAGCCCCGGGACACCCTACCCCCAGCAACCCCACTGCTTCCCCTTCTTG
GTATTAAGTGCAATTAAAGCCGTGGGTGTCGCATCTTCTCCAGCGCTGGGCCCTCCCTTGCCCCCAAGCTCAAGAAGGGGGCACTGCCCG
GCCCGGCTGTGAGGAGGGCGGCAGGGGGCACGGCCTCCAGCTTCCAAAGAGCAGCGAGCCGCGGAGCCGGGGAGTGCCCACAGACCCCAG
CCCCCGCGCCCCCGCCCTCCGCCGCTGGTTTGTAATGGAACCTTTTCTGTGCCCCTATCTTCCCGGAGACCACGCTTCTCCTCCGTGCCG
TGCGACCCCCACCCCATGACTATTGTGCGATTCGTGAGCGCCGCCCGAGCGGAGTTGGTAACTTGTTGGGTTTTTTTCCAACCATCATGG
CCTTATCTGTTCCAGTTTTCTCAGTGTTTTCAGCCTGTGAGATAGATGTTTATGGCAAGAAAAAGGAAAAAAAAATGGAAATCTGACCTA
TTGTATAAAAATCACTATTTTGTGTGCTCCGCGTGCTATAGCTTTTGGGGCGGCCCTGCCCAGTCCCCGTGCCCACGGGGCTCCCTCTCC
CGGTGGTGAAAGTGTCCACACGTGTGGTAGTCTAGTGTGCCGAGCTGTTTTCTACCTTTTTGTAGTCTTTCTTAAAACAATAAATTCCGC

>15097_15097_3_CDH8-RFX1_CDH8_chr16_61935083_ENST00000584337_RFX1_chr19_14083939_ENST00000254325_length(amino acids)=658AA_BP=43
MYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPMYVSGSQVVASSTSTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAG
TYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGN
SKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDL
QGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLLSKFEPVLQWTK
HCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQI
NQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFLLKWSFYSSMVI
RDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDH8-RFX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDH8-RFX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDH8-RFX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource