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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CDK14-SAV1 (FusionGDB2 ID:15182) |
Fusion Gene Summary for CDK14-SAV1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDK14-SAV1 | Fusion gene ID: 15182 | Hgene | Tgene | Gene symbol | CDK14 | SAV1 | Gene ID | 5218 | 60485 |
| Gene name | cyclin dependent kinase 14 | salvador family WW domain containing protein 1 | |
| Synonyms | PFTAIRE1|PFTK1 | SAV|WW45|WWP4 | |
| Cytomap | 7q21.13 | 14q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-dependent kinase 14PFTAIRE protein kinase 1cell division protein kinase 14serine/threonine-protein kinase PFTAIRE-1 | protein salvador homolog 11700040G09Rik45 kDa WW domain proteinWW domain-containing adaptor 45hWW45salvador homolog 1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | O94921 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000265741, ENST00000380050, ENST00000406263, ENST00000436577, ENST00000496279, | ENST00000324679, | |
| Fusion gene scores | * DoF score | 17 X 13 X 8=1768 | 4 X 3 X 4=48 |
| # samples | 18 | 4 | |
| ** MAII score | log2(18/1768*10)=-3.29604946306176 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CDK14 [Title/Abstract] AND SAV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CDK14(90675275)-SAV1(51111732), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDK14 | GO:0000086 | G2/M transition of mitotic cell cycle | 20059949 |
| Hgene | CDK14 | GO:0060828 | regulation of canonical Wnt signaling pathway | 20059949 |
| Fusion gene breakpoints across CDK14 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SAV1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | MESO | TCGA-TS-A8AF-01A | CDK14 | chr7 | 90675275 | - | SAV1 | chr14 | 51111732 | - |
| ChimerDB4 | MESO | TCGA-TS-A8AF-01A | CDK14 | chr7 | 90675275 | + | SAV1 | chr14 | 51111732 | - |
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Fusion Gene ORF analysis for CDK14-SAV1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000265741 | ENST00000324679 | CDK14 | chr7 | 90675275 | + | SAV1 | chr14 | 51111732 | - |
| In-frame | ENST00000380050 | ENST00000324679 | CDK14 | chr7 | 90675275 | + | SAV1 | chr14 | 51111732 | - |
| In-frame | ENST00000406263 | ENST00000324679 | CDK14 | chr7 | 90675275 | + | SAV1 | chr14 | 51111732 | - |
| In-frame | ENST00000436577 | ENST00000324679 | CDK14 | chr7 | 90675275 | + | SAV1 | chr14 | 51111732 | - |
| intron-3CDS | ENST00000496279 | ENST00000324679 | CDK14 | chr7 | 90675275 | + | SAV1 | chr14 | 51111732 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000380050 | CDK14 | chr7 | 90675275 | + | ENST00000324679 | SAV1 | chr14 | 51111732 | - | 3400 | 1236 | 77 | 1852 | 591 |
| ENST00000265741 | CDK14 | chr7 | 90675275 | + | ENST00000324679 | SAV1 | chr14 | 51111732 | - | 3359 | 1195 | 144 | 1811 | 555 |
| ENST00000406263 | CDK14 | chr7 | 90675275 | + | ENST00000324679 | SAV1 | chr14 | 51111732 | - | 3573 | 1409 | 442 | 2025 | 527 |
| ENST00000436577 | CDK14 | chr7 | 90675275 | + | ENST00000324679 | SAV1 | chr14 | 51111732 | - | 3147 | 983 | 256 | 1599 | 447 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000380050 | ENST00000324679 | CDK14 | chr7 | 90675275 | + | SAV1 | chr14 | 51111732 | - | 0.000419382 | 0.99958056 |
| ENST00000265741 | ENST00000324679 | CDK14 | chr7 | 90675275 | + | SAV1 | chr14 | 51111732 | - | 0.000274785 | 0.99972516 |
| ENST00000406263 | ENST00000324679 | CDK14 | chr7 | 90675275 | + | SAV1 | chr14 | 51111732 | - | 0.000300413 | 0.9996996 |
| ENST00000436577 | ENST00000324679 | CDK14 | chr7 | 90675275 | + | SAV1 | chr14 | 51111732 | - | 0.000702103 | 0.99929786 |
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Fusion Genomic Features for CDK14-SAV1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CDK14-SAV1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:90675275/chr14:51111732) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDK14 | . |
| FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CDK14 | chr7:90675275 | chr14:51111732 | ENST00000265741 | + | 10 | 14 | 141_149 | 350 | 1522.6666666666667 | Nucleotide binding | ATP |
| Hgene | CDK14 | chr7:90675275 | chr14:51111732 | ENST00000380050 | + | 11 | 15 | 141_149 | 368 | 1538.0 | Nucleotide binding | ATP |
| Hgene | CDK14 | chr7:90675275 | chr14:51111732 | ENST00000406263 | + | 10 | 14 | 141_149 | 322 | 1422.0 | Nucleotide binding | ATP |
| Tgene | SAV1 | chr7:90675275 | chr14:51111732 | ENST00000324679 | 1 | 5 | 344_373 | 178 | 384.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | SAV1 | chr7:90675275 | chr14:51111732 | ENST00000324679 | 1 | 5 | 199_232 | 178 | 384.0 | Domain | WW 1 | |
| Tgene | SAV1 | chr7:90675275 | chr14:51111732 | ENST00000324679 | 1 | 5 | 234_267 | 178 | 384.0 | Domain | WW 2 | |
| Tgene | SAV1 | chr7:90675275 | chr14:51111732 | ENST00000324679 | 1 | 5 | 321_368 | 178 | 384.0 | Domain | SARAH |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CDK14 | chr7:90675275 | chr14:51111732 | ENST00000265741 | + | 10 | 14 | 135_419 | 350 | 1522.6666666666667 | Domain | Protein kinase |
| Hgene | CDK14 | chr7:90675275 | chr14:51111732 | ENST00000380050 | + | 11 | 15 | 135_419 | 368 | 1538.0 | Domain | Protein kinase |
| Hgene | CDK14 | chr7:90675275 | chr14:51111732 | ENST00000406263 | + | 10 | 14 | 135_419 | 322 | 1422.0 | Domain | Protein kinase |
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Fusion Gene Sequence for CDK14-SAV1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >15182_15182_1_CDK14-SAV1_CDK14_chr7_90675275_ENST00000265741_SAV1_chr14_51111732_ENST00000324679_length(transcript)=3359nt_BP=1195nt GCATCCCCTTGATTAAATGTTTTTCCTCCTATGCAATCACCATTAGCTGTTTGGCTCCCATTCTGTATTCTTCTGAAGCAGCCCTGCATT GCAAATCAATATCTTTCTGAAAAGACAGTGTGTTGTGAATTGCCTTGACAGCATATGCACGGTTACTTTGGCTGCAATGCTGCTGCAGAG CCCGGTTACTCTGCCTTCGTGGGAACTCCACAGATATGTGTCACAAAGATGTCTACACGGAACTGCCAGGGAATGGACTCAGTGATCAAA CCCCTGGACACAATTCCTGAGGATAAAAAAGTCAGAGTTCAGAGGACACAGAGCACTTTTGACCCATTTGAGAAACCAGCTAATCAAGTA AAGAGGGTGCATTCTGAGAACAATGCTTGCATTAACTTTAAGACCTCCTCCACTGGCAAAGAGTCACCTAAAGTTAGGCGGCACTCCAGC CCCAGCTCGCCAACAAGTCCCAAATTTGGAAAAGCTGACTCATATGAAAAGCTGGAAAAACTAGGGGAAGGATCTTATGCTACAGTATAC AAAGGGAAAAGCAAGGTAAATGGGAAGTTGGTAGCTCTGAAGGTGATCAGGCTGCAGGAAGAAGAAGGGACACCTTTCACAGCTATCAGG GAAGCTTCTCTTTTAAAAGGACTAAAACATGCTAACATAGTGCTACTTCATGACATCATCCATACCAAGGAGACGCTGACACTTGTGTTT GAATATGTGCACACTGATTTATGTCAGTACATGGACAAGCACCCTGGGGGGCTGCATCCAGATAATGTGAAGTTGTTTTTATTTCAGTTG CTGCGAGGTCTGTCTTACATCCACCAGCGTTATATTTTGCACAGAGACCTGAAACCACAGAACCTTCTGATCAGTGACACGGGGGAGTTA AAGCTGGCAGATTTCGGTCTTGCAAGAGCAAAATCCGTCCCTAGCCACACATACTCCAACGAAGTGGTTACCTTGTGGTACAGACCTCCA GATGTCCTTCTAGGCTCAACAGAATATTCCACCTGCCTTGACATGTGGGGAGTAGGTTGCATCTTTGTTGAAATGATCCAAGGAGTTGCT GCTTTTCCAGGAATGAAAGACATTCAGGATCAACTTGAACGAATATTTCTGGTTCTTGGAACACCAAATGAGGACACATGGCCTGGAGTT CATTCTTTACCACATTTTAAGCCAGGTATTGGGAGAGTTGCTGCTACATCTTTAGGAAATTTGACTAACCATGGTTCTGAAGATTTACCC CTTCCTCCTGGCTGGTCTGTGGACTGGACAATGAGAGGGAGAAAATATTATATAGATCATAACACAAATACAACTCACTGGAGCCATCCT CTTGAGCGAGAAGGACTTCCTCCTGGATGGGAACGAGTTGAGTCATCCGAATTTGGAACCTATTATGTAGATCACACAAATAAGAAGGCC CAATACAGGCATCCCTGTGCTCCTAGTGTACCTCGGTATGATCAACCACCTCCTGTCACATACCAGCCACAGCAAACTGAAAGAAATCAG TCCCTTCTGGTACCTGCAAATCCATATCATACTGCAGAAATTCCTGACTGGCTTCAGGTTTACGCACGAGCCCCTGTGAAATATGACCAC ATTCTGAAGTGGGAACTCTTCCAGCTGGCTGACCTGGATACATACCAGGGAATGCTAAAGTTGCTCTTCATGAAAGAATTGGAGCAGATT GTTAAAATGTATGAAGCATACAGACAAGCCCTTCTTACAGAGTTGGAAAACCGAAAGCAGAGACAGCAGTGGTATGCCCAACAACATGGA AAAAATTTTTGAGCTGATTTTTTAAAAATTTAAGTTTTGTAAGAGCTTTAAAATATTTTCACAGATAAAAAATTGCAAACAAGTACTCTG GTTAATAAATGCTGCTTCCTTTGTGGAAATTATAAAATTCTAACTTTACATGTATTTTGTTATTAGAAATTTTCTTTTATTGAATGAGAA AAATTAGTCTATCATTTTAAGAGCCAATATGGCAAACACTTTCAAATACTGTATATTAGGAAACTGTTTTGGTATTCTTGATGGAAAAAA ACGCAGCGGAAATGTCATTATGAACAGATGTTAAATAGGAAATTATTACTTGTTAACTTCTTACAGCAGTAGTACCTTCTTTAAAAAAAA AAAAGAATCTGCGGTATTTTTTTAAAAAAAAAGTTTACCGCTGTAGTGTGAAATATTGTCTGGAAAGGGATGGTTTAAATATTACCATGA TGTAGTTGAAATATAAAATAGGATTTGGAACCTTATTGTGATAAATATTTATATATGATGTATGTTTGTCTCCCCTCTCCAAAGTAAGGA ACCCAGCTGGGCGTGGTGGCTCACTCCTGTAATCCCAGCATTTTGGGAGGCCGAGGTGGGTGGACCGCTTGAGTCCACGAGTTTAAGACC AGCCTGGGCAACATGGTGAAGCCCCATCTCTACAAAAAATACAAAAAAATTAGCCGGGTATGATGGTGTGTGCCTCTAGTCCCAGCTACT TGGGAGGCTGAGGTCAGAGGATGGCTTGAGCCCAAGAGGCAGAGGTTGCAGGGTCAAGATCGCACCACTTGCACTGCAGCCTGAGAGAGA GAGAGCCAGACCTTGTCTCAAAAAATAAAAAATAAAAAAATAAAAACAAAATAAGGAATCCTTTTAAAGCATGTTGAGAAAGTATTTTTT GGTATGAATGGGTGACGGGCCTTTTAATCTTTCAGGAATACATATAAGCAGGAATACTTAGCCTGTATTGGGAAGGTGCGTGAAACTCAA AGTTGCTAACATCATCTTCCTTATTTTCAGCCAGTGCTGTTACTGCATTTAGCATGGCTCTGACGAGGCAGTGGAGAGTTCCTGACAGCA TAGCATACTGCCTTCTGACAGACTGGGTTAAGCTACCAAAAATGACAACCAGGGATTCAAAAAAAATTTTTGGTCATTAAATCGAATGTA TATTATTACTTTTTAATTTTCTAAGTATTTATCACAGGACTTTAACACCATATATTTCCCTCCCAGTTTTTCTCCCCTTTTGGTTTAATA GTTAAAACATTTTTCATAATTAGTGCTGTACATTTGATTGCAAACAAATTGGTGATACTTCTAAACTATAACTATAAATCTCTAGAATTC TGTGAATTTCAACATTATTTGAAGTAGTTCTTCAGTTATATTTACATGTGTTGTAAATATGTAAATATACTTTTAGCTTAGGAAGTCTTC CAGAATACAAACTACTCCCAGTTAGATATCAGTGAGTTTGAATAACTGAAGAAATGTTGACAATGTTAAGTGTTTGATTTTATATAACAA >15182_15182_1_CDK14-SAV1_CDK14_chr7_90675275_ENST00000265741_SAV1_chr14_51111732_ENST00000324679_length(amino acids)=555AA_BP=350 MHGYFGCNAAAEPGYSAFVGTPQICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSST GKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHD IIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTY SNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPGIGRVAATSL GNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPP VTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENR -------------------------------------------------------------- >15182_15182_2_CDK14-SAV1_CDK14_chr7_90675275_ENST00000380050_SAV1_chr14_51111732_ENST00000324679_length(transcript)=3400nt_BP=1236nt CGTCGCTTCCCGGCCCGCCGAGGAGGTGGTGGAGGAGGAGGCGCCGCTTTCCCCGCGGCGCGCGCCCTCGCCGTTGTCTGAGCTGTGCCT GGACCAGTTTGGGGAAGTTGTCGGGGCTCCGCGTCGCCCAGATGTGTGACCTCATTGAGCCGCAGCCGGCCGAGAAGATCGGCAAGATGA AGAAGTTGCGGAGAACTTTGTCGGAGAGTTTCAGTCGCATTGCTTTGAAGAAAGATGACACCACCTTTGATGAGATATGTGTCACAAAGA TGTCTACACGGAACTGCCAGGGAATGGACTCAGTGATCAAACCCCTGGACACAATTCCTGAGGATAAAAAAGTCAGAGTTCAGAGGACAC AGAGCACTTTTGACCCATTTGAGAAACCAGCTAATCAAGTAAAGAGGGTGCATTCTGAGAACAATGCTTGCATTAACTTTAAGACCTCCT CCACTGGCAAAGAGTCACCTAAAGTTAGGCGGCACTCCAGCCCCAGCTCGCCAACAAGTCCCAAATTTGGAAAAGCTGACTCATATGAAA AGCTGGAAAAACTAGGGGAAGGATCTTATGCTACAGTATACAAAGGGAAAAGCAAGGTAAATGGGAAGTTGGTAGCTCTGAAGGTGATCA GGCTGCAGGAAGAAGAAGGGACACCTTTCACAGCTATCAGGGAAGCTTCTCTTTTAAAAGGACTAAAACATGCTAACATAGTGCTACTTC ATGACATCATCCATACCAAGGAGACGCTGACACTTGTGTTTGAATATGTGCACACTGATTTATGTCAGTACATGGACAAGCACCCTGGGG GGCTGCATCCAGATAATGTGAAGTTGTTTTTATTTCAGTTGCTGCGAGGTCTGTCTTACATCCACCAGCGTTATATTTTGCACAGAGACC TGAAACCACAGAACCTTCTGATCAGTGACACGGGGGAGTTAAAGCTGGCAGATTTCGGTCTTGCAAGAGCAAAATCCGTCCCTAGCCACA CATACTCCAACGAAGTGGTTACCTTGTGGTACAGACCTCCAGATGTCCTTCTAGGCTCAACAGAATATTCCACCTGCCTTGACATGTGGG GAGTAGGTTGCATCTTTGTTGAAATGATCCAAGGAGTTGCTGCTTTTCCAGGAATGAAAGACATTCAGGATCAACTTGAACGAATATTTC TGGTTCTTGGAACACCAAATGAGGACACATGGCCTGGAGTTCATTCTTTACCACATTTTAAGCCAGGTATTGGGAGAGTTGCTGCTACAT CTTTAGGAAATTTGACTAACCATGGTTCTGAAGATTTACCCCTTCCTCCTGGCTGGTCTGTGGACTGGACAATGAGAGGGAGAAAATATT ATATAGATCATAACACAAATACAACTCACTGGAGCCATCCTCTTGAGCGAGAAGGACTTCCTCCTGGATGGGAACGAGTTGAGTCATCCG AATTTGGAACCTATTATGTAGATCACACAAATAAGAAGGCCCAATACAGGCATCCCTGTGCTCCTAGTGTACCTCGGTATGATCAACCAC CTCCTGTCACATACCAGCCACAGCAAACTGAAAGAAATCAGTCCCTTCTGGTACCTGCAAATCCATATCATACTGCAGAAATTCCTGACT GGCTTCAGGTTTACGCACGAGCCCCTGTGAAATATGACCACATTCTGAAGTGGGAACTCTTCCAGCTGGCTGACCTGGATACATACCAGG GAATGCTAAAGTTGCTCTTCATGAAAGAATTGGAGCAGATTGTTAAAATGTATGAAGCATACAGACAAGCCCTTCTTACAGAGTTGGAAA ACCGAAAGCAGAGACAGCAGTGGTATGCCCAACAACATGGAAAAAATTTTTGAGCTGATTTTTTAAAAATTTAAGTTTTGTAAGAGCTTT AAAATATTTTCACAGATAAAAAATTGCAAACAAGTACTCTGGTTAATAAATGCTGCTTCCTTTGTGGAAATTATAAAATTCTAACTTTAC ATGTATTTTGTTATTAGAAATTTTCTTTTATTGAATGAGAAAAATTAGTCTATCATTTTAAGAGCCAATATGGCAAACACTTTCAAATAC TGTATATTAGGAAACTGTTTTGGTATTCTTGATGGAAAAAAACGCAGCGGAAATGTCATTATGAACAGATGTTAAATAGGAAATTATTAC TTGTTAACTTCTTACAGCAGTAGTACCTTCTTTAAAAAAAAAAAAGAATCTGCGGTATTTTTTTAAAAAAAAAGTTTACCGCTGTAGTGT GAAATATTGTCTGGAAAGGGATGGTTTAAATATTACCATGATGTAGTTGAAATATAAAATAGGATTTGGAACCTTATTGTGATAAATATT TATATATGATGTATGTTTGTCTCCCCTCTCCAAAGTAAGGAACCCAGCTGGGCGTGGTGGCTCACTCCTGTAATCCCAGCATTTTGGGAG GCCGAGGTGGGTGGACCGCTTGAGTCCACGAGTTTAAGACCAGCCTGGGCAACATGGTGAAGCCCCATCTCTACAAAAAATACAAAAAAA TTAGCCGGGTATGATGGTGTGTGCCTCTAGTCCCAGCTACTTGGGAGGCTGAGGTCAGAGGATGGCTTGAGCCCAAGAGGCAGAGGTTGC AGGGTCAAGATCGCACCACTTGCACTGCAGCCTGAGAGAGAGAGAGCCAGACCTTGTCTCAAAAAATAAAAAATAAAAAAATAAAAACAA AATAAGGAATCCTTTTAAAGCATGTTGAGAAAGTATTTTTTGGTATGAATGGGTGACGGGCCTTTTAATCTTTCAGGAATACATATAAGC AGGAATACTTAGCCTGTATTGGGAAGGTGCGTGAAACTCAAAGTTGCTAACATCATCTTCCTTATTTTCAGCCAGTGCTGTTACTGCATT TAGCATGGCTCTGACGAGGCAGTGGAGAGTTCCTGACAGCATAGCATACTGCCTTCTGACAGACTGGGTTAAGCTACCAAAAATGACAAC CAGGGATTCAAAAAAAATTTTTGGTCATTAAATCGAATGTATATTATTACTTTTTAATTTTCTAAGTATTTATCACAGGACTTTAACACC ATATATTTCCCTCCCAGTTTTTCTCCCCTTTTGGTTTAATAGTTAAAACATTTTTCATAATTAGTGCTGTACATTTGATTGCAAACAAAT TGGTGATACTTCTAAACTATAACTATAAATCTCTAGAATTCTGTGAATTTCAACATTATTTGAAGTAGTTCTTCAGTTATATTTACATGT GTTGTAAATATGTAAATATACTTTTAGCTTAGGAAGTCTTCCAGAATACAAACTACTCCCAGTTAGATATCAGTGAGTTTGAATAACTGA >15182_15182_2_CDK14-SAV1_CDK14_chr7_90675275_ENST00000380050_SAV1_chr14_51111732_ENST00000324679_length(amino acids)=591AA_BP=5 MSCAWTSLGKLSGLRVAQMCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVR VQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVA LKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYI LHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQL ERIFLVLGTPNEDTWPGVHSLPHFKPGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWER VESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADL -------------------------------------------------------------- >15182_15182_3_CDK14-SAV1_CDK14_chr7_90675275_ENST00000406263_SAV1_chr14_51111732_ENST00000324679_length(transcript)=3573nt_BP=1409nt CTTGACAGCATATGCACGGTTACTTTGGCTGCAATGCTGCTGCAGAGCCCGGTTACTCTGCCTTCGTGGGAACTCCACAGGCAAGTCCAT CGTGTTTGGAAAAAAAAATTAGATTTTTTGGAGAAAATAATTGAGCTGTTAAAGCTATTGATACTGAATGTTAGCATGTCCTTTGAGTTC TTCTCAACAGTTTTTGGTCTTATTCCACTGAGATTAGCTTCTCTTAGGGGATTTCTGGGCTTTTTTTTTTTTGCTTGCTTATGCATCCCC CTCTCTTGGTTGTAGTACGGCCGTACCATTTCAGCTTGCTAGTGCAGAAAGATGTGAATTCAGTTGCTGTATGAGCCTGGCCTGGTGCAA ACACATTGCTAGAGACATGTTAAAGAGTTCCAGGTGAATCAAGCCTGAGGGAGACAACAGCAAAACGATATGTGTCACAAAGATGTCTAC ACGGAACTGCCAGGGAATGGACTCAGTGATCAAACCCCTGGACACAATTCCTGAGGATAAAAAAGTCAGAGTTCAGAGGACACAGAGCAC TTTTGACCCATTTGAGAAACCAGCTAATCAAGTAAAGAGGGTGCATTCTGAGAACAATGCTTGCATTAACTTTAAGACCTCCTCCACTGG CAAAGAGTCACCTAAAGTTAGGCGGCACTCCAGCCCCAGCTCGCCAACAAGTCCCAAATTTGGAAAAGCTGACTCATATGAAAAGCTGGA AAAACTAGGGGAAGGATCTTATGCTACAGTATACAAAGGGAAAAGCAAGGTAAATGGGAAGTTGGTAGCTCTGAAGGTGATCAGGCTGCA GGAAGAAGAAGGGACACCTTTCACAGCTATCAGGGAAGCTTCTCTTTTAAAAGGACTAAAACATGCTAACATAGTGCTACTTCATGACAT CATCCATACCAAGGAGACGCTGACACTTGTGTTTGAATATGTGCACACTGATTTATGTCAGTACATGGACAAGCACCCTGGGGGGCTGCA TCCAGATAATGTGAAGTTGTTTTTATTTCAGTTGCTGCGAGGTCTGTCTTACATCCACCAGCGTTATATTTTGCACAGAGACCTGAAACC ACAGAACCTTCTGATCAGTGACACGGGGGAGTTAAAGCTGGCAGATTTCGGTCTTGCAAGAGCAAAATCCGTCCCTAGCCACACATACTC CAACGAAGTGGTTACCTTGTGGTACAGACCTCCAGATGTCCTTCTAGGCTCAACAGAATATTCCACCTGCCTTGACATGTGGGGAGTAGG TTGCATCTTTGTTGAAATGATCCAAGGAGTTGCTGCTTTTCCAGGAATGAAAGACATTCAGGATCAACTTGAACGAATATTTCTGGTTCT TGGAACACCAAATGAGGACACATGGCCTGGAGTTCATTCTTTACCACATTTTAAGCCAGGTATTGGGAGAGTTGCTGCTACATCTTTAGG AAATTTGACTAACCATGGTTCTGAAGATTTACCCCTTCCTCCTGGCTGGTCTGTGGACTGGACAATGAGAGGGAGAAAATATTATATAGA TCATAACACAAATACAACTCACTGGAGCCATCCTCTTGAGCGAGAAGGACTTCCTCCTGGATGGGAACGAGTTGAGTCATCCGAATTTGG AACCTATTATGTAGATCACACAAATAAGAAGGCCCAATACAGGCATCCCTGTGCTCCTAGTGTACCTCGGTATGATCAACCACCTCCTGT CACATACCAGCCACAGCAAACTGAAAGAAATCAGTCCCTTCTGGTACCTGCAAATCCATATCATACTGCAGAAATTCCTGACTGGCTTCA GGTTTACGCACGAGCCCCTGTGAAATATGACCACATTCTGAAGTGGGAACTCTTCCAGCTGGCTGACCTGGATACATACCAGGGAATGCT AAAGTTGCTCTTCATGAAAGAATTGGAGCAGATTGTTAAAATGTATGAAGCATACAGACAAGCCCTTCTTACAGAGTTGGAAAACCGAAA GCAGAGACAGCAGTGGTATGCCCAACAACATGGAAAAAATTTTTGAGCTGATTTTTTAAAAATTTAAGTTTTGTAAGAGCTTTAAAATAT TTTCACAGATAAAAAATTGCAAACAAGTACTCTGGTTAATAAATGCTGCTTCCTTTGTGGAAATTATAAAATTCTAACTTTACATGTATT TTGTTATTAGAAATTTTCTTTTATTGAATGAGAAAAATTAGTCTATCATTTTAAGAGCCAATATGGCAAACACTTTCAAATACTGTATAT TAGGAAACTGTTTTGGTATTCTTGATGGAAAAAAACGCAGCGGAAATGTCATTATGAACAGATGTTAAATAGGAAATTATTACTTGTTAA CTTCTTACAGCAGTAGTACCTTCTTTAAAAAAAAAAAAGAATCTGCGGTATTTTTTTAAAAAAAAAGTTTACCGCTGTAGTGTGAAATAT TGTCTGGAAAGGGATGGTTTAAATATTACCATGATGTAGTTGAAATATAAAATAGGATTTGGAACCTTATTGTGATAAATATTTATATAT GATGTATGTTTGTCTCCCCTCTCCAAAGTAAGGAACCCAGCTGGGCGTGGTGGCTCACTCCTGTAATCCCAGCATTTTGGGAGGCCGAGG TGGGTGGACCGCTTGAGTCCACGAGTTTAAGACCAGCCTGGGCAACATGGTGAAGCCCCATCTCTACAAAAAATACAAAAAAATTAGCCG GGTATGATGGTGTGTGCCTCTAGTCCCAGCTACTTGGGAGGCTGAGGTCAGAGGATGGCTTGAGCCCAAGAGGCAGAGGTTGCAGGGTCA AGATCGCACCACTTGCACTGCAGCCTGAGAGAGAGAGAGCCAGACCTTGTCTCAAAAAATAAAAAATAAAAAAATAAAAACAAAATAAGG AATCCTTTTAAAGCATGTTGAGAAAGTATTTTTTGGTATGAATGGGTGACGGGCCTTTTAATCTTTCAGGAATACATATAAGCAGGAATA CTTAGCCTGTATTGGGAAGGTGCGTGAAACTCAAAGTTGCTAACATCATCTTCCTTATTTTCAGCCAGTGCTGTTACTGCATTTAGCATG GCTCTGACGAGGCAGTGGAGAGTTCCTGACAGCATAGCATACTGCCTTCTGACAGACTGGGTTAAGCTACCAAAAATGACAACCAGGGAT TCAAAAAAAATTTTTGGTCATTAAATCGAATGTATATTATTACTTTTTAATTTTCTAAGTATTTATCACAGGACTTTAACACCATATATT TCCCTCCCAGTTTTTCTCCCCTTTTGGTTTAATAGTTAAAACATTTTTCATAATTAGTGCTGTACATTTGATTGCAAACAAATTGGTGAT ACTTCTAAACTATAACTATAAATCTCTAGAATTCTGTGAATTTCAACATTATTTGAAGTAGTTCTTCAGTTATATTTACATGTGTTGTAA ATATGTAAATATACTTTTAGCTTAGGAAGTCTTCCAGAATACAAACTACTCCCAGTTAGATATCAGTGAGTTTGAATAACTGAAGAAATG >15182_15182_3_CDK14-SAV1_CDK14_chr7_90675275_ENST00000406263_SAV1_chr14_51111732_ENST00000324679_length(amino acids)=527AA_BP=322 MSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYE KLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPG GLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMW GVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKY YIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPD -------------------------------------------------------------- >15182_15182_4_CDK14-SAV1_CDK14_chr7_90675275_ENST00000436577_SAV1_chr14_51111732_ENST00000324679_length(transcript)=3147nt_BP=983nt AGTTGCTGTATGAGCCTGGCCTGGTGCAAACACATTGCTAGAGACATGTTAAAGAGTTCCAGGTGAATCAAGCCTGAGGGAGACAACAGC AAAACGATATGTGTCACAAAGATGTCTACACGGAACTGCCAGGGAATGGACTCAGTGATCAAACCCCTGGACACAATTCCTGAGGATAAA AAAGTCAGAGTTCAGAGGACACAGAGCACTTTTGACCCATTTGAGAAACCAGCTAATCAAGTAAAGAGGGTGCATTCTGAGAACAATGCT TGCATTAACTTTAAGACCTCCTCCACTGGCAAAGAGTCACCTAAAGTTAGGCGGCACTCCAGCCCCAGCTCGGGTAAATGGGAAGTTGGT AGCTCTGAAGGTGATCAGGCTGCAGGAAGAAGAAGGGACACCTTTCACAGCTATCAGGGAAGCTTCTCTTTTAAAAGGACTAAAACATGC TAACATAGTGCTACTTCATGACATCATCCATACCAAGGAGACGCTGACACTTGTGTTTGAATATGTGCACACTGATTTATGTCAGTACAT GGACAAGCACCCTGGGGGGCTGCATCCAGATAATGTGAAGTTGTTTTTATTTCAGTTGCTGCGAGGTCTGTCTTACATCCACCAGCGTTA TATTTTGCACAGAGACCTGAAACCACAGAACCTTCTGATCAGTGACACGGGGGAGTTAAAGCTGGCAGATTTCGGTCTTGCAAGAGCAAA ATCCGTCCCTAGCCACACATACTCCAACGAAGTGGTTACCTTGTGGTACAGACCTCCAGATGTCCTTCTAGGCTCAACAGAATATTCCAC CTGCCTTGACATGTGGGGAGTAGGTTGCATCTTTGTTGAAATGATCCAAGGAGTTGCTGCTTTTCCAGGAATGAAAGACATTCAGGATCA ACTTGAACGAATATTTCTGGTTCTTGGAACACCAAATGAGGACACATGGCCTGGAGTTCATTCTTTACCACATTTTAAGCCAGGTATTGG GAGAGTTGCTGCTACATCTTTAGGAAATTTGACTAACCATGGTTCTGAAGATTTACCCCTTCCTCCTGGCTGGTCTGTGGACTGGACAAT GAGAGGGAGAAAATATTATATAGATCATAACACAAATACAACTCACTGGAGCCATCCTCTTGAGCGAGAAGGACTTCCTCCTGGATGGGA ACGAGTTGAGTCATCCGAATTTGGAACCTATTATGTAGATCACACAAATAAGAAGGCCCAATACAGGCATCCCTGTGCTCCTAGTGTACC TCGGTATGATCAACCACCTCCTGTCACATACCAGCCACAGCAAACTGAAAGAAATCAGTCCCTTCTGGTACCTGCAAATCCATATCATAC TGCAGAAATTCCTGACTGGCTTCAGGTTTACGCACGAGCCCCTGTGAAATATGACCACATTCTGAAGTGGGAACTCTTCCAGCTGGCTGA CCTGGATACATACCAGGGAATGCTAAAGTTGCTCTTCATGAAAGAATTGGAGCAGATTGTTAAAATGTATGAAGCATACAGACAAGCCCT TCTTACAGAGTTGGAAAACCGAAAGCAGAGACAGCAGTGGTATGCCCAACAACATGGAAAAAATTTTTGAGCTGATTTTTTAAAAATTTA AGTTTTGTAAGAGCTTTAAAATATTTTCACAGATAAAAAATTGCAAACAAGTACTCTGGTTAATAAATGCTGCTTCCTTTGTGGAAATTA TAAAATTCTAACTTTACATGTATTTTGTTATTAGAAATTTTCTTTTATTGAATGAGAAAAATTAGTCTATCATTTTAAGAGCCAATATGG CAAACACTTTCAAATACTGTATATTAGGAAACTGTTTTGGTATTCTTGATGGAAAAAAACGCAGCGGAAATGTCATTATGAACAGATGTT AAATAGGAAATTATTACTTGTTAACTTCTTACAGCAGTAGTACCTTCTTTAAAAAAAAAAAAGAATCTGCGGTATTTTTTTAAAAAAAAA GTTTACCGCTGTAGTGTGAAATATTGTCTGGAAAGGGATGGTTTAAATATTACCATGATGTAGTTGAAATATAAAATAGGATTTGGAACC TTATTGTGATAAATATTTATATATGATGTATGTTTGTCTCCCCTCTCCAAAGTAAGGAACCCAGCTGGGCGTGGTGGCTCACTCCTGTAA TCCCAGCATTTTGGGAGGCCGAGGTGGGTGGACCGCTTGAGTCCACGAGTTTAAGACCAGCCTGGGCAACATGGTGAAGCCCCATCTCTA CAAAAAATACAAAAAAATTAGCCGGGTATGATGGTGTGTGCCTCTAGTCCCAGCTACTTGGGAGGCTGAGGTCAGAGGATGGCTTGAGCC CAAGAGGCAGAGGTTGCAGGGTCAAGATCGCACCACTTGCACTGCAGCCTGAGAGAGAGAGAGCCAGACCTTGTCTCAAAAAATAAAAAA TAAAAAAATAAAAACAAAATAAGGAATCCTTTTAAAGCATGTTGAGAAAGTATTTTTTGGTATGAATGGGTGACGGGCCTTTTAATCTTT CAGGAATACATATAAGCAGGAATACTTAGCCTGTATTGGGAAGGTGCGTGAAACTCAAAGTTGCTAACATCATCTTCCTTATTTTCAGCC AGTGCTGTTACTGCATTTAGCATGGCTCTGACGAGGCAGTGGAGAGTTCCTGACAGCATAGCATACTGCCTTCTGACAGACTGGGTTAAG CTACCAAAAATGACAACCAGGGATTCAAAAAAAATTTTTGGTCATTAAATCGAATGTATATTATTACTTTTTAATTTTCTAAGTATTTAT CACAGGACTTTAACACCATATATTTCCCTCCCAGTTTTTCTCCCCTTTTGGTTTAATAGTTAAAACATTTTTCATAATTAGTGCTGTACA TTTGATTGCAAACAAATTGGTGATACTTCTAAACTATAACTATAAATCTCTAGAATTCTGTGAATTTCAACATTATTTGAAGTAGTTCTT CAGTTATATTTACATGTGTTGTAAATATGTAAATATACTTTTAGCTTAGGAAGTCTTCCAGAATACAAACTACTCCCAGTTAGATATCAG >15182_15182_4_CDK14-SAV1_CDK14_chr7_90675275_ENST00000436577_SAV1_chr14_51111732_ENST00000324679_length(amino acids)=447AA_BP=242 MRTMLALTLRPPPLAKSHLKLGGTPAPARVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTD LCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGS TEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPGIGRVAATSLGNLTNHGSEDLPLPPGWS VDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CDK14-SAV1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CDK14-SAV1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CDK14-SAV1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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