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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ACSL6-ACSL6 (FusionGDB2 ID:1519)

Fusion Gene Summary for ACSL6-ACSL6

Fusion gene summary

Fusion gene information	Fusion gene name: ACSL6-ACSL6
	Fusion gene ID: 1519
		Hgene	Tgene
	Gene symbol	ACSL6	ACSL6
	Gene ID	23305	23305
	Gene name	acyl-CoA synthetase long chain family member 6	acyl-CoA synthetase long chain family member 6
	Synonyms	ACS2\|FACL6\|LACS 6\|LACS2\|LACS5	ACS2\|FACL6\|LACS 6\|LACS2\|LACS5
	Cytomap	5q31.1	5q31.1
	Type of gene	protein-coding	protein-coding
	Description	long-chain-fatty-acid--CoA ligase 6arachidonate--CoA ligasefatty-acid-Coenzyme A ligase, long-chain 6long fatty acyl-CoA synthetase 2	long-chain-fatty-acid--CoA ligase 6arachidonate--CoA ligasefatty-acid-Coenzyme A ligase, long-chain 6long fatty acyl-CoA synthetase 2
	Modification date	20200313	20200313
	UniProtAcc	Q9UKU0	Q9UKU0
	Ensembl transtripts involved in fusion gene	ENST00000296869, ENST00000357096, ENST00000379240, ENST00000379244, ENST00000379246, ENST00000379249, ENST00000379255, ENST00000379264, ENST00000379272, ENST00000431707, ENST00000477640, ENST00000543479, ENST00000544770,	ENST00000296869, ENST00000379244, ENST00000379246, ENST00000379249, ENST00000379255, ENST00000379264, ENST00000379272, ENST00000543479, ENST00000544770, ENST00000357096, ENST00000379240, ENST00000431707, ENST00000477640,
Fusion gene scores	* DoF score	5 X 4 X 3=60	6 X 8 X 8=384
	# samples	4	10
	** MAII score	log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/384*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ACSL6 [Title/Abstract] AND ACSL6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACSL6(131325201)-ACSL6(131324603), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ACSL6	GO:0001676	long-chain fatty acid metabolic process	24269233
Tgene	ACSL6	GO:0001676	long-chain fatty acid metabolic process	24269233

Fusion gene breakpoints across ACSL6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACSL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BE766684	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-

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Fusion Gene ORF analysis for ACSL6-ACSL6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000296869	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000296869	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000296869	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000296869	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000296869	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000296869	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000296869	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000296869	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000296869	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000357096	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000357096	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000357096	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000357096	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000357096	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000357096	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000357096	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000357096	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000357096	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379240	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379240	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379240	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379240	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379240	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379240	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379240	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379240	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379240	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379244	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379244	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379244	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379244	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379244	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379244	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379244	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379244	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379244	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379246	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379246	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379246	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379246	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379246	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379246	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379246	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379246	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379246	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379249	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379249	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379249	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379249	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379249	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379249	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379249	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379249	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379249	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379255	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379255	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379255	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379255	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379255	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379255	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379255	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379255	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379255	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379264	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379264	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379264	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379264	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379264	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379264	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379264	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379264	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379264	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379272	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379272	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379272	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379272	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379272	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379272	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379272	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379272	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000379272	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000431707	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000431707	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000431707	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000431707	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000431707	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000431707	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000431707	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000431707	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000431707	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000477640	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000477640	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000477640	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000477640	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000477640	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000477640	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000477640	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000477640	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000477640	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000543479	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000543479	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000543479	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000543479	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000543479	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000543479	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000543479	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000543479	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000543479	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000544770	ENST00000296869	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000544770	ENST00000379244	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000544770	ENST00000379246	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000544770	ENST00000379249	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000544770	ENST00000379255	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000544770	ENST00000379264	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000544770	ENST00000379272	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000544770	ENST00000543479	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-3CDS	ENST00000544770	ENST00000544770	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000296869	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000296869	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000296869	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000296869	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000357096	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000357096	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000357096	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000357096	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379240	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379240	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379240	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379240	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379244	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379244	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379244	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379244	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379246	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379246	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379246	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379246	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379249	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379249	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379249	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379249	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379255	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379255	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379255	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379255	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379264	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379264	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379264	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379264	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379272	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379272	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379272	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000379272	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000431707	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000431707	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000431707	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000431707	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000477640	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000477640	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000477640	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000477640	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000543479	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000543479	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000543479	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000543479	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000544770	ENST00000357096	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000544770	ENST00000379240	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000544770	ENST00000431707	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-
intron-intron	ENST00000544770	ENST00000477640	ACSL6	chr5	131325201	+	ACSL6	chr5	131324603	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ACSL6-ACSL6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACSL6-ACSL6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:131325201/:131324603)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ACSL6 Q9UKU0	ACSL6 Q9UKU0
FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. {ECO:0000269\|PubMed:22633490, ECO:0000269\|PubMed:24269233}.	FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. {ECO:0000269\|PubMed:22633490, ECO:0000269\|PubMed:24269233}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ACSL6-ACSL6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACSL6-ACSL6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ACSL6-ACSL6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ACSL6-ACSL6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source