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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDK17-USP30 (FusionGDB2 ID:15209)

Fusion Gene Summary for CDK17-USP30

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK17-USP30
Fusion gene ID: 15209
HgeneTgene
Gene symbol

CDK17

USP30

Gene ID

5128

84749

Gene namecyclin dependent kinase 17ubiquitin specific peptidase 30
SynonymsPCTAIRE2|PCTK2-
Cytomap

12q23.1

12q24.11

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 17PCTAIRE-motif protein kinase 2cell division protein kinase 17protein kinase cdc2-related PCTAIRE-2serine/threonine-protein kinase PCTAIRE-2ubiquitin carboxyl-terminal hydrolase 30deubiquitinating enzyme 30ub-specific protease 30ubiquitin thioesterase 30ubiquitin thiolesterase 30ubiquitin-specific protease 30ubiquitin-specific-processing protease 30
Modification date2020031320200313
UniProtAcc

Q00537

.
Ensembl transtripts involved in fusion geneENST00000542666, ENST00000261211, 
ENST00000543119, ENST00000553042, 
ENST00000257548, ENST00000392784, 
Fusion gene scores* DoF score8 X 6 X 3=1444 X 4 X 3=48
# samples 76
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDK17 [Title/Abstract] AND USP30 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDK17(96704830)-USP30(109505329), # samples:2
Anticipated loss of major functional domain due to fusion event.CDK17-USP30 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CDK17-USP30 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CDK17-USP30 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CDK17-USP30 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUSP30

GO:0000422

autophagy of mitochondrion

25621951

TgeneUSP30

GO:0016579

protein deubiquitination

14715245|24896179

TgeneUSP30

GO:0035871

protein K11-linked deubiquitination

25621951

TgeneUSP30

GO:0044313

protein K6-linked deubiquitination

25621951


check buttonFusion gene breakpoints across CDK17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across USP30 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB36-01ACDK17chr12

96704830

-USP30chr12

109505329

+


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Fusion Gene ORF analysis for CDK17-USP30

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000542666ENST00000257548CDK17chr12

96704830

-USP30chr12

109505329

+
Frame-shiftENST00000542666ENST00000392784CDK17chr12

96704830

-USP30chr12

109505329

+
In-frameENST00000261211ENST00000257548CDK17chr12

96704830

-USP30chr12

109505329

+
In-frameENST00000261211ENST00000392784CDK17chr12

96704830

-USP30chr12

109505329

+
In-frameENST00000543119ENST00000257548CDK17chr12

96704830

-USP30chr12

109505329

+
In-frameENST00000543119ENST00000392784CDK17chr12

96704830

-USP30chr12

109505329

+
intron-3CDSENST00000553042ENST00000257548CDK17chr12

96704830

-USP30chr12

109505329

+
intron-3CDSENST00000553042ENST00000392784CDK17chr12

96704830

-USP30chr12

109505329

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000261211CDK17chr1296704830-ENST00000392784USP30chr12109505329+2771114711492324391
ENST00000261211CDK17chr1296704830-ENST00000257548USP30chr12109505329+4420114711492324391
ENST00000543119CDK17chr1296704830-ENST00000392784USP30chr12109505329+2691106710692244391
ENST00000543119CDK17chr1296704830-ENST00000257548USP30chr12109505329+4340106710692244391

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261211ENST00000392784CDK17chr1296704830-USP30chr12109505329+0.053469260.94653076
ENST00000261211ENST00000257548CDK17chr1296704830-USP30chr12109505329+0.0476165670.9523834
ENST00000543119ENST00000392784CDK17chr1296704830-USP30chr12109505329+0.0564777850.9435222
ENST00000543119ENST00000257548CDK17chr1296704830-USP30chr12109505329+0.0500885020.94991153

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Fusion Genomic Features for CDK17-USP30


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDK17chr1296704829-USP30chr12109505328+3.44E-081
CDK17chr1296704829-USP30chr12109505328+3.44E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDK17-USP30


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:96704830/chr12:109505329)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK17

Q00537

.
FUNCTION: May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK17chr12:96704830chr12:109505329ENST00000261211-517192_473181524.0DomainProtein kinase
HgeneCDK17chr12:96704830chr12:109505329ENST00000543119-516192_473181524.0DomainProtein kinase
HgeneCDK17chr12:96704830chr12:109505329ENST00000261211-517198_206181524.0Nucleotide bindingATP
HgeneCDK17chr12:96704830chr12:109505329ENST00000543119-516198_206181524.0Nucleotide bindingATP
TgeneUSP30chr12:96704830chr12:109505329ENST0000025754821368_502125518.0DomainNote=USP
TgeneUSP30chr12:96704830chr12:109505329ENST000002575482131_35125518.0Topological domainMitochondrial intermembrane
TgeneUSP30chr12:96704830chr12:109505329ENST0000025754821357_517125518.0Topological domainCytoplasmic
TgeneUSP30chr12:96704830chr12:109505329ENST0000025754821336_56125518.0TransmembraneHelical


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Fusion Gene Sequence for CDK17-USP30


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15209_15209_1_CDK17-USP30_CDK17_chr12_96704830_ENST00000261211_USP30_chr12_109505329_ENST00000257548_length(transcript)=4420nt_BP=1147nt
GCGGGGGTGGGGTAAGCTCCCGCGGCCGGTCGCTTTTCTCCGCCGCCGCTGGTTGGATCGTTTCAATAAAAGTGTTTTTTCTCTTGCACT
CGCTCTCCTCCGGGGAACAGGCGGAGGCGTCAATCCGCAGCCGCCGAGTGTGAAAGCGACGCACACGCAAGGAGCGAACGCGGCCGCCCG
CAGTCTCCTGAGCTCCCCGCGGGCCGCCGCAGAGCCGCGGAGAAGGAGCCAGCGCCCGGCCAGACAGTCTCAGCCCGCCGTCGGCGCCCG
CCGCGCTCGCGCCCGGCTGCTCCGAGGGGATTAGTGGGCCGTCCGCGCGGCTCGTCGGCGCGGGAGCCATGTTGACCGAGGGACTTGGCA
ACGCGTGAGACACCCGCGGCCCCTCCCGAGGCTCCGGACCCGCGGCGAGAGCCGGAAGGCGGCTGTGGCGGCGGAGGCCTGCGCTCGGAA
GCGCCTCACGTCTGCCGGCCGCTGAGACCCGGACTTGCATCCGGTCGCCGCGGGCGTCCGCGGAGCAGCTTCCCCCCGCGCCTCTCTTCG
CCTCGCCTCGGGACCCGCGGTCCCCGCTCTTGCTGGATTTTTCAAGCCACATTCAATTGATAGGATGAAAAAATTTAAGAGAAGGCTATC
CCTCACACTCCGAGGAAGTCAGACTATTGATGAATCATTGTCTGAATTGGCTGAACAAATGACTATTGAAGAAAACAGCAGCAAGGATAA
TGAGCCTATTGTGAAGAATGGCAGGCCTCCAACGTCTCACAGTATGCATTCCTTCCTCCACCAGTACACAGGATCTTTCAAGAAGCCCCC
ATTGCGGAGACCACACAGTGTTATTGGAGGGAGCCTTGGCTCCTTCATGGCAATGCCCAGAAATGGAAGCAGATTAGATATTGTTCATGA
AAATCTAAAAATGGGATCAGATGGTGAGAGTGACCAAGCTTCTGGGACATCATCTGATGAAGTCCAGTCACCTACAGGTGTTTGTCTCAG
AAATCGTATACATAGACGGATCTCAATGGAGGATTTAAATAAGCGGTTATCACTGCCTGCAGACATCAGAATACCTGATGGATATCTTGA
AAAGTTGCAGATAAACAGTCCACCATTTGACCAACCAATGAGTCGAAGGTCTCGTAGAGCTTCCTTACCTTGTCCTGCCAAGAAGTTACT
GATGATGAGGTCTTAGATGCAAGCTGCTTGTTGGATGTCTTAAGAATGTACAGATGGCAGATCTCATCATTTGAAGAACAGGATGCTCAC
GAATTATTCCATGTCATTACCTCGTCATTGGAAGATGAGCGAGACCGCCAGCCTCGGGTCACACATTTGTTTGATGTGCATTCCCTGGAG
CAGCAGTCAGAAATAACTCCCAAACAAATTACCTGCCGCACAAGAGGGTCACCTCACCCTACATCCAATCACTGGAAGTCTCAACATCCT
TTTCATGGAAGACTCACTAGTAATATGGTCTGCAAACACTGTGAACACCAGAGTCCTGTTCGATTTGATACCTTTGATAGCCTTTCACTA
AGTATTCCAGCCGCCACATGGGGTCACCCATTGACCCTGGACCACTGCCTTCACCACTTCATCTCATCAGAATCAGTGCGGGATGTTGTG
TGTGACAACTGTACAAAGATTGAAGCCAAGGGAACGTTGAACGGGGAAAAGGTGGAACACCAGAGGACCACTTTTGTTAAACAGTTAAAA
CTAGGGAAGCTCCCTCAGTGTCTCTGCATCCACCTACAGCGGCTGAGCTGGTCCAGCCACGGCACGCCTCTGAAGCGGCATGAGCACGTG
CAGTTCAATGAGTTCCTGATGATGGACATTTACAAGTACCACCTCCTTGGACATAAACCTAGTCAACACAACCCTAAACTGAACAAGAAC
CCAGGGCCTACACTGGAGCTGCAGGATGGGCCGGGAGCCCCCACACCAGTTCTGAATCAGCCAGGGGCCCCCAAAACACAGATTTTTATG
AATGGCGCCTGCTCCCCATCTTTATTGCCAACGCTGTCAGCGCCGATGCCCTTCCCTCTCCCAGTTGTTCCCGACTACAGCTCCTCCACA
TACCTCTTCCGGCTGATGGCAGTTGTCGTCCACCATGGAGACATGCACTCTGGACACTTTGTCACTTACCGACGGTCCCCACCTTCTGCC
AGGAACCCTCTCTCAACTAGCAATCAGTGGCTGTGGGTCTCCGATGACACTGTCCGCAAGGCCAGCCTGCAGGAGGTCCTGTCCTCCAGC
GCCTACCTGCTGTTCTACGAGCGCGTCCTTTCCAGGATGCAGCACCAGAGCCAGGAGTGCAAGTCTGAAGAATGACTGTGCCCTCCTGCA
AGGCTAGAGCTGATGGCACTGTCTGCACTGTCCAGGAAAAAAGTAAAACTGTACTGTTGCGTGTGCAAGCGGCCCCACTAGAGCCTTCCA
GCCTTCTGGTGTGTTCTAAGAGCAGGCTCCACCTGGGAGCCAGCCCCAGTTCACACCAAACCAGGCTCCCTGAACAGTCCTGTTCATGTG
TGTAGGTGGTTCTGTTGTGTTAAGAAAGCATTCATTATGTCCGGAGTGTCTTTTTACTCATCTGATACAGGTAATTAAAAGAACTCAGAT
TCTTGAAGCCACCGTTTTCATATTGTAATGTTAGGTGTTCTCAGAGGGGAGGTACCTTTGTCTAATCAACGTTTCCACTTAGATCTTTTA
TTTTTAATAAGCAGGCCCATAAAAATTGTTGACAAGAATTAATGAAATTATTAAAGGCAACAATTTAGAAGAAAAAGTGCCTTTCACTTT
CGATTGCTTTTGTAGCACGTCCATTGTGAAATATTCCTTCCAGGCTACTCAAAGGATAGCAAGAGAACAGGTAAATGATGCCTAAAGAAC
ACCTTCCTTTTTCTATGCCTTTTCTAATCTTTCAATTCTTTCTATGGAGTAAAGGCTCATCTGCCAAATCTGCCCCCTGGGGAAACTCTT
TCACTACTTTGTCAGTTATAAGTGAAGAGCTTACTTGTTGCTTTTATCTTTTGTATATTGGACTGAGATGTAATTACACTGTATTATAAA
ACTCTGTGAATAGCCAGAACTGAGCTGGATCTTTGCAACACCTGATTCCTCTGCTCTGTGGAAAACTTTTTCTTACACAAGGATCCACTG
TGGACGGTTACTTTCATCTGTTTATTTATTGCCCATGCAGAGCTCTTAAGGTTTACAGGTGGGAGCTTGGGGCTGTATAAAAAAATAATC
CCTGCCCTGAGTTGACACCTGGCTTAGGAAGGAAGGGCTGACTATGGGGCTGCAGTCTCTCTGAACCTCAGTTTCCTCATTTGTGAAGTG
AAGGGTTAGATTTGATGACCACCAAAGTTCAGCCCTTTTCACGAAAAGGAGAAAGCAGCTTTTGACTTTTTAAAAAACATATAACTACAG
CTGGCATCTAGTATTGTCATGTTGCTCTAGGTCCATATTCTGAATTTATTCATTTCCAATAGCCTAATACAAAAAGTATATATTGAGCAC
TTTCTTCCCTTTTCAGGTAAGTCTCTGAATGCAGCCCAGGGCCAAAGGAATTTTGATGACACAGTAGTACCTATGTTTTAAGCTATATTT
TTAATTTAGAAAAATGGATACCAAATTCAAACCGACTCATCAGAGGTAAGATTTGGAATCAGACCTTTCCAAAAGGTCATCTGAGGTAAG
GCTAAGACCGCACTTCCTCTGCTGGGGGTGAGCTGGCAGACACACCAAACAGTGCCTTGGCAGCAGCTCACAGTGCAGGAAGCCCAGGTG
ATCACTCTTCTGCTGGGCCCAGGCTGCACCCTGAGGACTCAGTAACTCACTCTCAACAGAATATTCTGTGCAGGCTCTCCAGGCTCTGGG
CGTCAGGGTGCAAGGGGCAGCTTGAACTGTACGGTCCGTCCTGCACTCACCCGATGCAGACCTTGACTTTGATGTTGAAATGAACACACT
TGTTTTACCCAAGTCTGGTGGAACAAATGCCCAATCATGTGACCTTAAAGTGTACTGCAAAGCTGTAGCTTTAAGTAATTGCTGTTCTGC
CACTGCTTACTCTGAAATCTACCATCAAAGAAAGATAGAGAAAAGGGGCTGAGCCTTGGAATATATGGTTATAAGCAGATCTTTCTTTGG
TCAGAGACCAGGGTTTGAGCCAAGGCTGTAAATGTGAACAATAGCTGTGCAAAGCCTTTTAACCTGACTTCTTCATTTTGTAAATTATTA
TGCATTAAGTAGCAGCCCAATAATCTGATTTCTAGTTTTATTTTCAAAGTAAGTAGCTTCTTTTGGGAAAAACCTAAGTTAAACTAGTAG
TTTTGCCATAATAACTGCTGATTTATGTATTTGCTAAAGGTACTTTTGTATCTGCTGTGTATTATAGCAATAAAATAATCATTTTGTTAG

>15209_15209_1_CDK17-USP30_CDK17_chr12_96704830_ENST00000261211_USP30_chr12_109505329_ENST00000257548_length(amino acids)=391AA_BP=1
MSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSN
HWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRT
TFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGA
PKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASL

--------------------------------------------------------------
>15209_15209_2_CDK17-USP30_CDK17_chr12_96704830_ENST00000261211_USP30_chr12_109505329_ENST00000392784_length(transcript)=2771nt_BP=1147nt
GCGGGGGTGGGGTAAGCTCCCGCGGCCGGTCGCTTTTCTCCGCCGCCGCTGGTTGGATCGTTTCAATAAAAGTGTTTTTTCTCTTGCACT
CGCTCTCCTCCGGGGAACAGGCGGAGGCGTCAATCCGCAGCCGCCGAGTGTGAAAGCGACGCACACGCAAGGAGCGAACGCGGCCGCCCG
CAGTCTCCTGAGCTCCCCGCGGGCCGCCGCAGAGCCGCGGAGAAGGAGCCAGCGCCCGGCCAGACAGTCTCAGCCCGCCGTCGGCGCCCG
CCGCGCTCGCGCCCGGCTGCTCCGAGGGGATTAGTGGGCCGTCCGCGCGGCTCGTCGGCGCGGGAGCCATGTTGACCGAGGGACTTGGCA
ACGCGTGAGACACCCGCGGCCCCTCCCGAGGCTCCGGACCCGCGGCGAGAGCCGGAAGGCGGCTGTGGCGGCGGAGGCCTGCGCTCGGAA
GCGCCTCACGTCTGCCGGCCGCTGAGACCCGGACTTGCATCCGGTCGCCGCGGGCGTCCGCGGAGCAGCTTCCCCCCGCGCCTCTCTTCG
CCTCGCCTCGGGACCCGCGGTCCCCGCTCTTGCTGGATTTTTCAAGCCACATTCAATTGATAGGATGAAAAAATTTAAGAGAAGGCTATC
CCTCACACTCCGAGGAAGTCAGACTATTGATGAATCATTGTCTGAATTGGCTGAACAAATGACTATTGAAGAAAACAGCAGCAAGGATAA
TGAGCCTATTGTGAAGAATGGCAGGCCTCCAACGTCTCACAGTATGCATTCCTTCCTCCACCAGTACACAGGATCTTTCAAGAAGCCCCC
ATTGCGGAGACCACACAGTGTTATTGGAGGGAGCCTTGGCTCCTTCATGGCAATGCCCAGAAATGGAAGCAGATTAGATATTGTTCATGA
AAATCTAAAAATGGGATCAGATGGTGAGAGTGACCAAGCTTCTGGGACATCATCTGATGAAGTCCAGTCACCTACAGGTGTTTGTCTCAG
AAATCGTATACATAGACGGATCTCAATGGAGGATTTAAATAAGCGGTTATCACTGCCTGCAGACATCAGAATACCTGATGGATATCTTGA
AAAGTTGCAGATAAACAGTCCACCATTTGACCAACCAATGAGTCGAAGGTCTCGTAGAGCTTCCTTACCTTGTCCTGCCAAGAAGTTACT
GATGATGAGGTCTTAGATGCAAGCTGCTTGTTGGATGTCTTAAGAATGTACAGATGGCAGATCTCATCATTTGAAGAACAGGATGCTCAC
GAATTATTCCATGTCATTACCTCGTCATTGGAAGATGAGCGAGACCGCCAGCCTCGGGTCACACATTTGTTTGATGTGCATTCCCTGGAG
CAGCAGTCAGAAATAACTCCCAAACAAATTACCTGCCGCACAAGAGGGTCACCTCACCCTACATCCAATCACTGGAAGTCTCAACATCCT
TTTCATGGAAGACTCACTAGTAATATGGTCTGCAAACACTGTGAACACCAGAGTCCTGTTCGATTTGATACCTTTGATAGCCTTTCACTA
AGTATTCCAGCCGCCACATGGGGTCACCCATTGACCCTGGACCACTGCCTTCACCACTTCATCTCATCAGAATCAGTGCGGGATGTTGTG
TGTGACAACTGTACAAAGATTGAAGCCAAGGGAACGTTGAACGGGGAAAAGGTGGAACACCAGAGGACCACTTTTGTTAAACAGTTAAAA
CTAGGGAAGCTCCCTCAGTGTCTCTGCATCCACCTACAGCGGCTGAGCTGGTCCAGCCACGGCACGCCTCTGAAGCGGCATGAGCACGTG
CAGTTCAATGAGTTCCTGATGATGGACATTTACAAGTACCACCTCCTTGGACATAAACCTAGTCAACACAACCCTAAACTGAACAAGAAC
CCAGGGCCTACACTGGAGCTGCAGGATGGGCCGGGAGCCCCCACACCAGTTCTGAATCAGCCAGGGGCCCCCAAAACACAGATTTTTATG
AATGGCGCCTGCTCCCCATCTTTATTGCCAACGCTGTCAGCGCCGATGCCCTTCCCTCTCCCAGTTGTTCCCGACTACAGCTCCTCCACA
TACCTCTTCCGGCTGATGGCAGTTGTCGTCCACCATGGAGACATGCACTCTGGACACTTTGTCACTTACCGACGGTCCCCACCTTCTGCC
AGGAACCCTCTCTCAACTAGCAATCAGTGGCTGTGGGTCTCCGATGACACTGTCCGCAAGGCCAGCCTGCAGGAGGTCCTGTCCTCCAGC
GCCTACCTGCTGTTCTACGAGCGCGTCCTTTCCAGGATGCAGCACCAGAGCCAGGAGTGCAAGTCTGAAGAATGACTGTGCCCTCCTGCA
AGGCTAGAGCTGATGGCACTGTCTGCACTGTCCAGGAAAAAAGTAAAACTGTACTGTTGCGTGTGCAAGCGGCCCCACTAGAGCCTTCCA
GCCTTCTGGTGTGTTCTAAGAGCAGGCTCCACCTGGGAGCCAGCCCCAGTTCACACCAAACCAGGCTCCCTGAACAGTCCTGTTCATGTG
TGTAGGTGGTTCTGTTGTGTTAAGAAAGCATTCATTATGTCCGGAGTGTCTTTTTACTCATCTGATACAGGTAATTAAAAGAACTCAGAT
TCTTGAAGCCACCGTTTTCATATTGTAATGTTAGGTGTTCTCAGAGGGGAGGTACCTTTGTCTAATCAACGTTTCCACTTAGATCTTTTA

>15209_15209_2_CDK17-USP30_CDK17_chr12_96704830_ENST00000261211_USP30_chr12_109505329_ENST00000392784_length(amino acids)=391AA_BP=1
MSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSN
HWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRT
TFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGA
PKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASL

--------------------------------------------------------------
>15209_15209_3_CDK17-USP30_CDK17_chr12_96704830_ENST00000543119_USP30_chr12_109505329_ENST00000257548_length(transcript)=4340nt_BP=1067nt
CTCTTGCACTCGCTCTCCTCCGGGGAACAGGCGGAGGCGTCAATCCGCAGCCGCCGAGTGTGAAAGCGACGCACACGCAAGGAGCGAACG
CGGCCGCCCGCAGTCTCCTGAGCTCCCCGCGGGCCGCCGCAGAGCCGCGGAGAAGGAGCCAGCGCCCGGCCAGACAGTCTCAGCCCGCCG
TCGGCGCCCGCCGCGCTCGCGCCCGGCTGCTCCGAGGGGATTAGTGGGCCGTCCGCGCGGCTCGTCGGCGCGGGAGCCATGTTGACCGAG
GGACTTGGCAACGCGTGAGACACCCGCGGCCCCTCCCGAGGCTCCGGACCCGCGGCGAGAGCCGGAAGGCGGCTGTGGCGGCGGAGGCCT
GCGCTCGGAAGCGCCTCACGTCTGCCGGCCGCTGAGACCCGGACTTGCATCCGGTCGCCGCGGGCGTCCGCGGAGCAGCTTCCCCCCGCG
CCTCTCTTCGCCTCGCCTCGGGACCCGCGGTCCCCGCTCTTGCTGGATTTTTCAAGCCACATTCAATTGATAGGATGAAAAAATTTAAGA
GAAGGCTATCCCTCACACTCCGAGGAAGTCAGACTATTGATGAATCATTGTCTGAATTGGCTGAACAAATGACTATTGAAGAAAACAGCA
GCAAGGATAATGAGCCTATTGTGAAGAATGGCAGGCCTCCAACGTCTCACAGTATGCATTCCTTCCTCCACCAGTACACAGGATCTTTCA
AGAAGCCCCCATTGCGGAGACCACACAGTGTTATTGGAGGGAGCCTTGGCTCCTTCATGGCAATGCCCAGAAATGGAAGCAGATTAGATA
TTGTTCATGAAAATCTAAAAATGGGATCAGATGGTGAGAGTGACCAAGCTTCTGGGACATCATCTGATGAAGTCCAGTCACCTACAGGTG
TTTGTCTCAGAAATCGTATACATAGACGGATCTCAATGGAGGATTTAAATAAGCGGTTATCACTGCCTGCAGACATCAGAATACCTGATG
GATATCTTGAAAAGTTGCAGATAAACAGTCCACCATTTGACCAACCAATGAGTCGAAGGTCTCGTAGAGCTTCCTTACCTTGTCCTGCCA
AGAAGTTACTGATGATGAGGTCTTAGATGCAAGCTGCTTGTTGGATGTCTTAAGAATGTACAGATGGCAGATCTCATCATTTGAAGAACA
GGATGCTCACGAATTATTCCATGTCATTACCTCGTCATTGGAAGATGAGCGAGACCGCCAGCCTCGGGTCACACATTTGTTTGATGTGCA
TTCCCTGGAGCAGCAGTCAGAAATAACTCCCAAACAAATTACCTGCCGCACAAGAGGGTCACCTCACCCTACATCCAATCACTGGAAGTC
TCAACATCCTTTTCATGGAAGACTCACTAGTAATATGGTCTGCAAACACTGTGAACACCAGAGTCCTGTTCGATTTGATACCTTTGATAG
CCTTTCACTAAGTATTCCAGCCGCCACATGGGGTCACCCATTGACCCTGGACCACTGCCTTCACCACTTCATCTCATCAGAATCAGTGCG
GGATGTTGTGTGTGACAACTGTACAAAGATTGAAGCCAAGGGAACGTTGAACGGGGAAAAGGTGGAACACCAGAGGACCACTTTTGTTAA
ACAGTTAAAACTAGGGAAGCTCCCTCAGTGTCTCTGCATCCACCTACAGCGGCTGAGCTGGTCCAGCCACGGCACGCCTCTGAAGCGGCA
TGAGCACGTGCAGTTCAATGAGTTCCTGATGATGGACATTTACAAGTACCACCTCCTTGGACATAAACCTAGTCAACACAACCCTAAACT
GAACAAGAACCCAGGGCCTACACTGGAGCTGCAGGATGGGCCGGGAGCCCCCACACCAGTTCTGAATCAGCCAGGGGCCCCCAAAACACA
GATTTTTATGAATGGCGCCTGCTCCCCATCTTTATTGCCAACGCTGTCAGCGCCGATGCCCTTCCCTCTCCCAGTTGTTCCCGACTACAG
CTCCTCCACATACCTCTTCCGGCTGATGGCAGTTGTCGTCCACCATGGAGACATGCACTCTGGACACTTTGTCACTTACCGACGGTCCCC
ACCTTCTGCCAGGAACCCTCTCTCAACTAGCAATCAGTGGCTGTGGGTCTCCGATGACACTGTCCGCAAGGCCAGCCTGCAGGAGGTCCT
GTCCTCCAGCGCCTACCTGCTGTTCTACGAGCGCGTCCTTTCCAGGATGCAGCACCAGAGCCAGGAGTGCAAGTCTGAAGAATGACTGTG
CCCTCCTGCAAGGCTAGAGCTGATGGCACTGTCTGCACTGTCCAGGAAAAAAGTAAAACTGTACTGTTGCGTGTGCAAGCGGCCCCACTA
GAGCCTTCCAGCCTTCTGGTGTGTTCTAAGAGCAGGCTCCACCTGGGAGCCAGCCCCAGTTCACACCAAACCAGGCTCCCTGAACAGTCC
TGTTCATGTGTGTAGGTGGTTCTGTTGTGTTAAGAAAGCATTCATTATGTCCGGAGTGTCTTTTTACTCATCTGATACAGGTAATTAAAA
GAACTCAGATTCTTGAAGCCACCGTTTTCATATTGTAATGTTAGGTGTTCTCAGAGGGGAGGTACCTTTGTCTAATCAACGTTTCCACTT
AGATCTTTTATTTTTAATAAGCAGGCCCATAAAAATTGTTGACAAGAATTAATGAAATTATTAAAGGCAACAATTTAGAAGAAAAAGTGC
CTTTCACTTTCGATTGCTTTTGTAGCACGTCCATTGTGAAATATTCCTTCCAGGCTACTCAAAGGATAGCAAGAGAACAGGTAAATGATG
CCTAAAGAACACCTTCCTTTTTCTATGCCTTTTCTAATCTTTCAATTCTTTCTATGGAGTAAAGGCTCATCTGCCAAATCTGCCCCCTGG
GGAAACTCTTTCACTACTTTGTCAGTTATAAGTGAAGAGCTTACTTGTTGCTTTTATCTTTTGTATATTGGACTGAGATGTAATTACACT
GTATTATAAAACTCTGTGAATAGCCAGAACTGAGCTGGATCTTTGCAACACCTGATTCCTCTGCTCTGTGGAAAACTTTTTCTTACACAA
GGATCCACTGTGGACGGTTACTTTCATCTGTTTATTTATTGCCCATGCAGAGCTCTTAAGGTTTACAGGTGGGAGCTTGGGGCTGTATAA
AAAAATAATCCCTGCCCTGAGTTGACACCTGGCTTAGGAAGGAAGGGCTGACTATGGGGCTGCAGTCTCTCTGAACCTCAGTTTCCTCAT
TTGTGAAGTGAAGGGTTAGATTTGATGACCACCAAAGTTCAGCCCTTTTCACGAAAAGGAGAAAGCAGCTTTTGACTTTTTAAAAAACAT
ATAACTACAGCTGGCATCTAGTATTGTCATGTTGCTCTAGGTCCATATTCTGAATTTATTCATTTCCAATAGCCTAATACAAAAAGTATA
TATTGAGCACTTTCTTCCCTTTTCAGGTAAGTCTCTGAATGCAGCCCAGGGCCAAAGGAATTTTGATGACACAGTAGTACCTATGTTTTA
AGCTATATTTTTAATTTAGAAAAATGGATACCAAATTCAAACCGACTCATCAGAGGTAAGATTTGGAATCAGACCTTTCCAAAAGGTCAT
CTGAGGTAAGGCTAAGACCGCACTTCCTCTGCTGGGGGTGAGCTGGCAGACACACCAAACAGTGCCTTGGCAGCAGCTCACAGTGCAGGA
AGCCCAGGTGATCACTCTTCTGCTGGGCCCAGGCTGCACCCTGAGGACTCAGTAACTCACTCTCAACAGAATATTCTGTGCAGGCTCTCC
AGGCTCTGGGCGTCAGGGTGCAAGGGGCAGCTTGAACTGTACGGTCCGTCCTGCACTCACCCGATGCAGACCTTGACTTTGATGTTGAAA
TGAACACACTTGTTTTACCCAAGTCTGGTGGAACAAATGCCCAATCATGTGACCTTAAAGTGTACTGCAAAGCTGTAGCTTTAAGTAATT
GCTGTTCTGCCACTGCTTACTCTGAAATCTACCATCAAAGAAAGATAGAGAAAAGGGGCTGAGCCTTGGAATATATGGTTATAAGCAGAT
CTTTCTTTGGTCAGAGACCAGGGTTTGAGCCAAGGCTGTAAATGTGAACAATAGCTGTGCAAAGCCTTTTAACCTGACTTCTTCATTTTG
TAAATTATTATGCATTAAGTAGCAGCCCAATAATCTGATTTCTAGTTTTATTTTCAAAGTAAGTAGCTTCTTTTGGGAAAAACCTAAGTT
AAACTAGTAGTTTTGCCATAATAACTGCTGATTTATGTATTTGCTAAAGGTACTTTTGTATCTGCTGTGTATTATAGCAATAAAATAATC

>15209_15209_3_CDK17-USP30_CDK17_chr12_96704830_ENST00000543119_USP30_chr12_109505329_ENST00000257548_length(amino acids)=391AA_BP=1
MSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSN
HWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRT
TFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGA
PKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASL

--------------------------------------------------------------
>15209_15209_4_CDK17-USP30_CDK17_chr12_96704830_ENST00000543119_USP30_chr12_109505329_ENST00000392784_length(transcript)=2691nt_BP=1067nt
CTCTTGCACTCGCTCTCCTCCGGGGAACAGGCGGAGGCGTCAATCCGCAGCCGCCGAGTGTGAAAGCGACGCACACGCAAGGAGCGAACG
CGGCCGCCCGCAGTCTCCTGAGCTCCCCGCGGGCCGCCGCAGAGCCGCGGAGAAGGAGCCAGCGCCCGGCCAGACAGTCTCAGCCCGCCG
TCGGCGCCCGCCGCGCTCGCGCCCGGCTGCTCCGAGGGGATTAGTGGGCCGTCCGCGCGGCTCGTCGGCGCGGGAGCCATGTTGACCGAG
GGACTTGGCAACGCGTGAGACACCCGCGGCCCCTCCCGAGGCTCCGGACCCGCGGCGAGAGCCGGAAGGCGGCTGTGGCGGCGGAGGCCT
GCGCTCGGAAGCGCCTCACGTCTGCCGGCCGCTGAGACCCGGACTTGCATCCGGTCGCCGCGGGCGTCCGCGGAGCAGCTTCCCCCCGCG
CCTCTCTTCGCCTCGCCTCGGGACCCGCGGTCCCCGCTCTTGCTGGATTTTTCAAGCCACATTCAATTGATAGGATGAAAAAATTTAAGA
GAAGGCTATCCCTCACACTCCGAGGAAGTCAGACTATTGATGAATCATTGTCTGAATTGGCTGAACAAATGACTATTGAAGAAAACAGCA
GCAAGGATAATGAGCCTATTGTGAAGAATGGCAGGCCTCCAACGTCTCACAGTATGCATTCCTTCCTCCACCAGTACACAGGATCTTTCA
AGAAGCCCCCATTGCGGAGACCACACAGTGTTATTGGAGGGAGCCTTGGCTCCTTCATGGCAATGCCCAGAAATGGAAGCAGATTAGATA
TTGTTCATGAAAATCTAAAAATGGGATCAGATGGTGAGAGTGACCAAGCTTCTGGGACATCATCTGATGAAGTCCAGTCACCTACAGGTG
TTTGTCTCAGAAATCGTATACATAGACGGATCTCAATGGAGGATTTAAATAAGCGGTTATCACTGCCTGCAGACATCAGAATACCTGATG
GATATCTTGAAAAGTTGCAGATAAACAGTCCACCATTTGACCAACCAATGAGTCGAAGGTCTCGTAGAGCTTCCTTACCTTGTCCTGCCA
AGAAGTTACTGATGATGAGGTCTTAGATGCAAGCTGCTTGTTGGATGTCTTAAGAATGTACAGATGGCAGATCTCATCATTTGAAGAACA
GGATGCTCACGAATTATTCCATGTCATTACCTCGTCATTGGAAGATGAGCGAGACCGCCAGCCTCGGGTCACACATTTGTTTGATGTGCA
TTCCCTGGAGCAGCAGTCAGAAATAACTCCCAAACAAATTACCTGCCGCACAAGAGGGTCACCTCACCCTACATCCAATCACTGGAAGTC
TCAACATCCTTTTCATGGAAGACTCACTAGTAATATGGTCTGCAAACACTGTGAACACCAGAGTCCTGTTCGATTTGATACCTTTGATAG
CCTTTCACTAAGTATTCCAGCCGCCACATGGGGTCACCCATTGACCCTGGACCACTGCCTTCACCACTTCATCTCATCAGAATCAGTGCG
GGATGTTGTGTGTGACAACTGTACAAAGATTGAAGCCAAGGGAACGTTGAACGGGGAAAAGGTGGAACACCAGAGGACCACTTTTGTTAA
ACAGTTAAAACTAGGGAAGCTCCCTCAGTGTCTCTGCATCCACCTACAGCGGCTGAGCTGGTCCAGCCACGGCACGCCTCTGAAGCGGCA
TGAGCACGTGCAGTTCAATGAGTTCCTGATGATGGACATTTACAAGTACCACCTCCTTGGACATAAACCTAGTCAACACAACCCTAAACT
GAACAAGAACCCAGGGCCTACACTGGAGCTGCAGGATGGGCCGGGAGCCCCCACACCAGTTCTGAATCAGCCAGGGGCCCCCAAAACACA
GATTTTTATGAATGGCGCCTGCTCCCCATCTTTATTGCCAACGCTGTCAGCGCCGATGCCCTTCCCTCTCCCAGTTGTTCCCGACTACAG
CTCCTCCACATACCTCTTCCGGCTGATGGCAGTTGTCGTCCACCATGGAGACATGCACTCTGGACACTTTGTCACTTACCGACGGTCCCC
ACCTTCTGCCAGGAACCCTCTCTCAACTAGCAATCAGTGGCTGTGGGTCTCCGATGACACTGTCCGCAAGGCCAGCCTGCAGGAGGTCCT
GTCCTCCAGCGCCTACCTGCTGTTCTACGAGCGCGTCCTTTCCAGGATGCAGCACCAGAGCCAGGAGTGCAAGTCTGAAGAATGACTGTG
CCCTCCTGCAAGGCTAGAGCTGATGGCACTGTCTGCACTGTCCAGGAAAAAAGTAAAACTGTACTGTTGCGTGTGCAAGCGGCCCCACTA
GAGCCTTCCAGCCTTCTGGTGTGTTCTAAGAGCAGGCTCCACCTGGGAGCCAGCCCCAGTTCACACCAAACCAGGCTCCCTGAACAGTCC
TGTTCATGTGTGTAGGTGGTTCTGTTGTGTTAAGAAAGCATTCATTATGTCCGGAGTGTCTTTTTACTCATCTGATACAGGTAATTAAAA
GAACTCAGATTCTTGAAGCCACCGTTTTCATATTGTAATGTTAGGTGTTCTCAGAGGGGAGGTACCTTTGTCTAATCAACGTTTCCACTT

>15209_15209_4_CDK17-USP30_CDK17_chr12_96704830_ENST00000543119_USP30_chr12_109505329_ENST00000392784_length(amino acids)=391AA_BP=1
MSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSN
HWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRT
TFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGA
PKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDK17-USP30


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDK17-USP30


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDK17-USP30


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource