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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDK2-PAN2 (FusionGDB2 ID:15243)

Fusion Gene Summary for CDK2-PAN2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK2-PAN2
Fusion gene ID: 15243
HgeneTgene
Gene symbol

CDK2

PAN2

Gene ID

1017

147945

Gene namecyclin dependent kinase 2NLR family pyrin domain containing 4
SynonymsCDKN2|p33(CDK2)CLR19.5|CT58|NALP4|PAN2|PYPAF4|RNH2
Cytomap

12q13.2

19q13.43

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 2cdc2-related protein kinasecell division protein kinase 2p33 protein kinaseNACHT, LRR and PYD domains-containing protein 4NACHT, leucine rich repeat and PYD containing 4PAAD and NACHT-containing protein 2PYRIN and NACHT-containing protein 2PYRIN-containing APAF1-like protein 4cancer/testis antigen 58nucleotide-binding olig
Modification date2020031320200313
UniProtAcc

P24941

PAN3

Ensembl transtripts involved in fusion geneENST00000556656, ENST00000266970, 
ENST00000553376, ENST00000354056, 
ENST00000440311, 		ENST00000257931, 
ENST00000425394, ENST00000440411, 
ENST00000548043, ENST00000549090, 
Fusion gene scores* DoF score4 X 4 X 2=323 X 2 X 3=18
# samples 44
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDK2 [Title/Abstract] AND PAN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDK2(56363360)-PAN2(56719238), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK2

GO:0006468

protein phosphorylation

12944431|28666995

HgeneCDK2

GO:0008284

positive regulation of cell proliferation

10767298

HgeneCDK2

GO:0016572

histone phosphorylation

11746698

HgeneCDK2

GO:0018105

peptidyl-serine phosphorylation

23184662

HgeneCDK2

GO:0060968

regulation of gene silencing

20935635


check buttonFusion gene breakpoints across CDK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PAN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HO-01ACDK2chr12

56363360

+PAN2chr12

56719238

-
ChimerDB4SARCTCGA-DX-A3LW-01ACDK2chr12

56363360

-PAN2chr12

56719238

-
ChimerDB4SARCTCGA-DX-A3LW-01ACDK2chr12

56363360

+PAN2chr12

56719238

-


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Fusion Gene ORF analysis for CDK2-PAN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000556656ENST00000257931CDK2chr12

56363360

+PAN2chr12

56719238

-
3UTR-3CDSENST00000556656ENST00000425394CDK2chr12

56363360

+PAN2chr12

56719238

-
3UTR-3CDSENST00000556656ENST00000440411CDK2chr12

56363360

+PAN2chr12

56719238

-
3UTR-3CDSENST00000556656ENST00000548043CDK2chr12

56363360

+PAN2chr12

56719238

-
3UTR-intronENST00000556656ENST00000549090CDK2chr12

56363360

+PAN2chr12

56719238

-
5CDS-intronENST00000266970ENST00000549090CDK2chr12

56363360

+PAN2chr12

56719238

-
5CDS-intronENST00000553376ENST00000549090CDK2chr12

56363360

+PAN2chr12

56719238

-
In-frameENST00000266970ENST00000257931CDK2chr12

56363360

+PAN2chr12

56719238

-
In-frameENST00000266970ENST00000425394CDK2chr12

56363360

+PAN2chr12

56719238

-
In-frameENST00000266970ENST00000440411CDK2chr12

56363360

+PAN2chr12

56719238

-
In-frameENST00000266970ENST00000548043CDK2chr12

56363360

+PAN2chr12

56719238

-
In-frameENST00000553376ENST00000257931CDK2chr12

56363360

+PAN2chr12

56719238

-
In-frameENST00000553376ENST00000425394CDK2chr12

56363360

+PAN2chr12

56719238

-
In-frameENST00000553376ENST00000440411CDK2chr12

56363360

+PAN2chr12

56719238

-
In-frameENST00000553376ENST00000548043CDK2chr12

56363360

+PAN2chr12

56719238

-
intron-3CDSENST00000354056ENST00000257931CDK2chr12

56363360

+PAN2chr12

56719238

-
intron-3CDSENST00000354056ENST00000425394CDK2chr12

56363360

+PAN2chr12

56719238

-
intron-3CDSENST00000354056ENST00000440411CDK2chr12

56363360

+PAN2chr12

56719238

-
intron-3CDSENST00000354056ENST00000548043CDK2chr12

56363360

+PAN2chr12

56719238

-
intron-3CDSENST00000440311ENST00000257931CDK2chr12

56363360

+PAN2chr12

56719238

-
intron-3CDSENST00000440311ENST00000425394CDK2chr12

56363360

+PAN2chr12

56719238

-
intron-3CDSENST00000440311ENST00000440411CDK2chr12

56363360

+PAN2chr12

56719238

-
intron-3CDSENST00000440311ENST00000548043CDK2chr12

56363360

+PAN2chr12

56719238

-
intron-intronENST00000354056ENST00000549090CDK2chr12

56363360

+PAN2chr12

56719238

-
intron-intronENST00000440311ENST00000549090CDK2chr12

56363360

+PAN2chr12

56719238

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000266970CDK2chr1256363360+ENST00000425394PAN2chr1256719238-44648287230771001
ENST00000266970CDK2chr1256363360+ENST00000440411PAN2chr1256719238-3739828723065997
ENST00000266970CDK2chr1256363360+ENST00000257931PAN2chr1256719238-37478287230741000
ENST00000266970CDK2chr1256363360+ENST00000548043PAN2chr1256719238-37408287230771001
ENST00000553376CDK2chr1256363360+ENST00000425394PAN2chr1256719238-44127762030251001
ENST00000553376CDK2chr1256363360+ENST00000440411PAN2chr1256719238-3687776203013997
ENST00000553376CDK2chr1256363360+ENST00000257931PAN2chr1256719238-36957762030221000
ENST00000553376CDK2chr1256363360+ENST00000548043PAN2chr1256719238-36887762030251001

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000266970ENST00000425394CDK2chr1256363360+PAN2chr1256719238-0.000773050.9992269
ENST00000266970ENST00000440411CDK2chr1256363360+PAN2chr1256719238-0.0008846780.9991153
ENST00000266970ENST00000257931CDK2chr1256363360+PAN2chr1256719238-0.0009815270.99901843
ENST00000266970ENST00000548043CDK2chr1256363360+PAN2chr1256719238-0.0009221550.9990778
ENST00000553376ENST00000425394CDK2chr1256363360+PAN2chr1256719238-0.0007550230.99924505
ENST00000553376ENST00000440411CDK2chr1256363360+PAN2chr1256719238-0.0008617470.99913824
ENST00000553376ENST00000257931CDK2chr1256363360+PAN2chr1256719238-0.0009579230.9990421
ENST00000553376ENST00000548043CDK2chr1256363360+PAN2chr1256719238-0.0008971210.99910295

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Fusion Genomic Features for CDK2-PAN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDK2-PAN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:56363360/chr12:56719238)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK2

P24941

PAN2

PAN3

FUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). {ECO:0000250|UniProtKB:P97377, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:11051553, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:12944431, ECO:0000269|PubMed:15800615, ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:18372919, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20079829, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20195506, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:21319273, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:29203878}.283

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK2chr12:56363360chr12:56719238ENST00000266970+5710_18196299.0Nucleotide bindingATP
HgeneCDK2chr12:56363360chr12:56719238ENST00000266970+57129_132196299.0Nucleotide bindingATP
HgeneCDK2chr12:56363360chr12:56719238ENST00000266970+5781_83196299.0Nucleotide bindingATP
TgenePAN2chr12:56363360chr12:56719238ENST00000257931726486_9244531202.0DomainUSP
TgenePAN2chr12:56363360chr12:56719238ENST00000257931726975_11474531202.0DomainExonuclease
TgenePAN2chr12:56363360chr12:56719238ENST00000425394726486_9244531203.0DomainUSP
TgenePAN2chr12:56363360chr12:56719238ENST00000425394726975_11474531203.0DomainExonuclease
TgenePAN2chr12:56363360chr12:56719238ENST00000440411726486_9244531199.0DomainUSP
TgenePAN2chr12:56363360chr12:56719238ENST00000440411726975_11474531199.0DomainExonuclease
TgenePAN2chr12:56363360chr12:56719238ENST00000548043726486_9244531203.0DomainUSP
TgenePAN2chr12:56363360chr12:56719238ENST00000548043726975_11474531203.0DomainExonuclease

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK2chr12:56363360chr12:56719238ENST00000266970+574_286196299.0DomainProtein kinase
HgeneCDK2chr12:56363360chr12:56719238ENST00000354056+164_2860265.0DomainProtein kinase
HgeneCDK2chr12:56363360chr12:56719238ENST00000354056+1610_180265.0Nucleotide bindingATP
HgeneCDK2chr12:56363360chr12:56719238ENST00000354056+16129_1320265.0Nucleotide bindingATP
HgeneCDK2chr12:56363360chr12:56719238ENST00000354056+1681_830265.0Nucleotide bindingATP
TgenePAN2chr12:56363360chr12:56719238ENST00000257931726368_4854531202.0RegionLinker
TgenePAN2chr12:56363360chr12:56719238ENST00000425394726368_4854531203.0RegionLinker
TgenePAN2chr12:56363360chr12:56719238ENST00000440411726368_4854531199.0RegionLinker
TgenePAN2chr12:56363360chr12:56719238ENST00000548043726368_4854531203.0RegionLinker
TgenePAN2chr12:56363360chr12:56719238ENST00000257931726153_1934531202.0RepeatWD 1
TgenePAN2chr12:56363360chr12:56719238ENST00000257931726195_2314531202.0RepeatWD 2
TgenePAN2chr12:56363360chr12:56719238ENST00000257931726244_2804531202.0RepeatWD 3
TgenePAN2chr12:56363360chr12:56719238ENST00000257931726328_3674531202.0RepeatWD 4
TgenePAN2chr12:56363360chr12:56719238ENST00000425394726153_1934531203.0RepeatWD 1
TgenePAN2chr12:56363360chr12:56719238ENST00000425394726195_2314531203.0RepeatWD 2
TgenePAN2chr12:56363360chr12:56719238ENST00000425394726244_2804531203.0RepeatWD 3
TgenePAN2chr12:56363360chr12:56719238ENST00000425394726328_3674531203.0RepeatWD 4
TgenePAN2chr12:56363360chr12:56719238ENST00000440411726153_1934531199.0RepeatWD 1
TgenePAN2chr12:56363360chr12:56719238ENST00000440411726195_2314531199.0RepeatWD 2
TgenePAN2chr12:56363360chr12:56719238ENST00000440411726244_2804531199.0RepeatWD 3
TgenePAN2chr12:56363360chr12:56719238ENST00000440411726328_3674531199.0RepeatWD 4
TgenePAN2chr12:56363360chr12:56719238ENST00000548043726153_1934531203.0RepeatWD 1
TgenePAN2chr12:56363360chr12:56719238ENST00000548043726195_2314531203.0RepeatWD 2
TgenePAN2chr12:56363360chr12:56719238ENST00000548043726244_2804531203.0RepeatWD 3
TgenePAN2chr12:56363360chr12:56719238ENST00000548043726328_3674531203.0RepeatWD 4


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Fusion Gene Sequence for CDK2-PAN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15243_15243_1_CDK2-PAN2_CDK2_chr12_56363360_ENST00000266970_PAN2_chr12_56719238_ENST00000257931_length(transcript)=3747nt_BP=828nt
AACGCGGGAAGCAGGGGCGGGGCCTCTGGTGGCGGTCGGGAACTCGGTGGGAGGCGGCAACATTGTTTCAAGTTGGCCAAATTGACAAGA
GCGAGAGGTATACTGCGTTCCATCCCGACCCGGGGCCACGGTACTGGGCCCTGTTTCCCCCTCCTCGGCCCCCGAGAGCCAGGGTCCGCC
TTCTGCAGGGTTCCCAGGCCCCCGCTCCAGGGCCGGGCTGACCCGACTCGCTGGCGCTTCATGGAGAACTTCCAAAAGGTGGAAAAGATC
GGAGAGGGCACGTACGGAGTTGTGTACAAAGCCAGAAACAAGTTGACGGGAGAGGTGGTGGCGCTTAAGAAAATCCGCCTGGACACTGAG
ACTGAGGGTGTGCCCAGTACTGCCATCCGAGAGATCTCTCTGCTTAAGGAGCTTAACCATCCTAATATTGTCAAGCTGCTGGATGTCATT
CACACAGAAAATAAACTCTACCTGGTTTTTGAATTTCTGCACCAAGATCTCAAGAAATTCATGGATGCCTCTGCTCTCACTGGCATTCCT
CTTCCCCTCATCAAGAGCTATCTGTTCCAGCTGCTCCAGGGCCTAGCTTTCTGCCATTCTCATCGGGTCCTCCACCGAGACCTTAAACCT
CAGAATCTGCTTATTAACACAGAGGGGGCCATCAAGCTAGCAGACTTTGGACTAGCCAGAGCTTTTGGAGTCCCTGTTCGTACTTACACC
CATGAGGTGGTGACCCTGTGGTACCGAGCTCCTGAAATCCTCCTGGGCTGCAAATATTATTCCACAGCTGTGGACATCTGGAGCCTGGGC
TGCATCTTTGCTGAGATGATACCCTACAGACTCAAGGAGTCAGACAGTGAATTTGACAGCTTCAGCCAGGTCACTGAGTCACCAGTAGGA
CGAGAAGAGGAACCACATCTCCACATGGTTTCTAAGAAATACCGCAAGGTGACCATCAAATATTCCAAGCTAGGGCTGGAGGACTTTGAC
TTCAAACACTACAATAAGACCTTGTTTGCTGGATTAGAGCCCCACATTCCCAACGCCTACTGTAACTGCATGATCCAGGTGCTCTATTTC
CTGGAGCCTGTACGCTGTCTAATTCAAAACCACCTTTGCCAGAAGGAGTTCTGTCTGGCATGTGAGCTGGGCTTCCTGTTTCACATGTTG
GACCTCTCTCGTGGTGACCCTTGCCAGGGCAATAATTTTCTTCGGGCATTCCGTACTATTCCTGAGGCCTCAGCCCTCGGTCTAATCCTG
GCTGACTCAGATGAGGCCTCAGGCAAGGGCAATCTGGCCAGGCTCATTCAGAGGTGGAATCGCTTCATTCTCACTCAACTGCATCAAGAT
ATGCAGGAGCTGGAAATACCACAGGCTTATCGAGGTGCTGGAGGCAGCTTTTGCTCATCGGGGGACTCTGTTATTGGGCAGCTCTTCAGC
TGTGAGATGGAGAACTGCAGCCTCTGCCGCTGTGGCAGTGAGACCGTGCGAGCCTCATCCACTCTGCTTTTCACACTCTCCTACCCTGAT
GGTAGCAAAAGTGATAAAACTGGGAAGAACTATGACTTTGCTCAGGTGCTGAAGCGAAGCATCTGCCTGGACCAGAATACACAGGCCTGG
TGTGACACCTGTGAAAAGTACCAGCCCACGATTCAGACCCGCAACATCCGCCATCTGCCAGATATTCTTGTCATCAATTGTGAGGTGAAC
AGCTCAAAAGAGGCTGATTTCTGGAGAATGCAGGCTGAGGTTGCCTTCAAGATGGCAGTAAAGAAACACGGTGGGGAAATCTCCAAGAAC
AAGGAATTTGCTTTGGCTGATTGGAAGGAACTAGGGAGTCCAGAGGGTGTGCTGGTGTGTCCCTCCATTGAGGAGTTGAAGAACGTCTGG
CTTCCTTTCTCCATTCGCATGAAGATGACCAAAAACAAAGGGCTGGATGTTTGCAATTGGACTGATGGGGATGAGATGCAGTGGGGCCCA
GCCAGGGCAGAGGAGGAGCATGGTGTCTATGTGTATGACCTGATGGCTACTGTGGTACACATCCTGGACTCACGCACAGGGGGCAGCCTG
GTGGCTCACATCAAAGTTGGAGAGACCTACCACCAGCGCAAGGAGGGCGTTACTCACCAGCAGTGGTATCTGTTCAATGACTTTCTTATT
GAACCTATTGATAAGCATGAAGCTGTGCAGTTTGACATGAATTGGAAAGTACCTGCAATCCTTTATTATGTCAAACGGAATCTCAATTCC
AGATACAACCTGAACATCAAGAACCCTATTGAGGCAAGTGTCTTGCTGGCTGAAGCCTCGCTGGCACGGAAGCAGCGGAAAACACATACT
ACCTTTATTCCACTGATGCTGAATGAGATGCCACAGATTGGGGACCTGGTGGGTCTGGATGCTGAGTTTGTCACCCTTAATGAGGAGGAA
GCAGAGTTACGCAGTGATGGTACCAAGTCTACCATTAAACCAAGCCAGATGTCAGTAGCCAGGATTACCTGTGTTCGGGGCCAGGGACCC
AATGAGGGTATCCCCTTCATTGATGACTACATCTCTACCCAGGAGCAGGTGGTGGATTACTTGACTCAATACTCGGGTATAAAGCCTGGT
GACCTCGATGCCAAAATTTCCTCCAAGCACCTAACAACTCTCAAGTCTACCTACTTAAAGCTTCGTTTTCTCATTGACATTGGAGTCAAG
TTTGTGGGTCATGGCCTGCAGAAGGACTTCCGGGTCATCAACCTGATGGTGCCCAAGGACCAAGTCCTTGACACTGTCTACCTGTTCCAT
ATGCCCCGAAAACGAATGATTTCCCTGCGATTCCTTGCTTGGTACTTTCTGGACCTGAAGATTCAAGGGGAAACCCATGACAGTATTGAG
GATGCCCGCACAGCCCTTCAGCTGTACCGAAAGTATCTGGAGCTAAGCAAAAATGGCACTGAGCCTGAGTCTTTCCACAAGGTGCTCAAG
GGTCTTTATGAGAAGGGCAGAAAGATGGACTGGAAGGTGCCTGAGCCTGAGGGCCAAACAAGTCCCAAGAATGCAGCTGTCTTCTCCTCA
GTGCTGGCGCTCTGACTACCCTTCCCAAAGAACCACGGCCCTCTCCCTTTACTGTTCTATAGCCCCAGAACTGGGAGATGGCTTCCTAAG
TTGGCTATACCTTGTCCACTTCCAGTACTGGACGTGCTCAGGGTCTAGGGTCACAGATGGTGCTATTAATTGAACTGGAACACAGCAGAA
TTGTTGCAAAGGTTCTAGGAGCCAGATTCATTCCTTCTTCATTCTTTGCAAAACAGTGGTACAGACATGGAGTCTAGAATTGACCCAGAT
GGAAAGTAATTGGTATTCTTAATATCCTGGGTGACTAATATCCAGGCAGAGAAGCTCCTGGAACCATAACTGTAAGTTCCTAGCTGGCTA
GGGATTGAAGTCCTGGACAGTGACAGAGGATACCACAGTAGTTCAAGACTTAGCACAAGTCACCAACTGCTTCAGGGATACCTGGAGGGG
CCAGCAAGTAGAGTGTTGGTGGCCCAAGCAAACCAGTGTTGCCAATACCATTGCCAAAAGGGCCTTTGGATCCTGGACAAAGCTTGGCTG
CCGGCTTCATTTATTCCTGCTGATGGCTGAGAAGCATCTGTCTTCCATCCCACTTGCCTGTCCCAAGTTTTGTTCCATTTTTTAAAAATT

>15243_15243_1_CDK2-PAN2_CDK2_chr12_56363360_ENST00000266970_PAN2_chr12_56719238_ENST00000257931_length(amino acids)=1000AA_BP=252
MAKLTRARGILRSIPTRGHGTGPCFPLLGPREPGSAFCRVPRPPLQGRADPTRWRFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKK
IRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL
HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMIPYRLKESDSEFDSFSQV
TESPVGREEEPHLHMVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELG
FLFHMLDLSRGDPCQGNNFLRAFRTIPEASALGLILADSDEASGKGNLARLIQRWNRFILTQLHQDMQELEIPQAYRGAGGSFCSSGDSV
IGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPDGSKSDKTGKNYDFAQVLKRSICLDQNTQAWCDTCEKYQPTIQTRNIRHLPDILV
INCEVNSSKEADFWRMQAEVAFKMAVKKHGGEISKNKEFALADWKELGSPEGVLVCPSIEELKNVWLPFSIRMKMTKNKGLDVCNWTDGD
EMQWGPARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKHEAVQFDMNWKVPAILYYV
KRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITC
VRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLD
TVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPEGQTSPKN

--------------------------------------------------------------
>15243_15243_2_CDK2-PAN2_CDK2_chr12_56363360_ENST00000266970_PAN2_chr12_56719238_ENST00000425394_length(transcript)=4464nt_BP=828nt
AACGCGGGAAGCAGGGGCGGGGCCTCTGGTGGCGGTCGGGAACTCGGTGGGAGGCGGCAACATTGTTTCAAGTTGGCCAAATTGACAAGA
GCGAGAGGTATACTGCGTTCCATCCCGACCCGGGGCCACGGTACTGGGCCCTGTTTCCCCCTCCTCGGCCCCCGAGAGCCAGGGTCCGCC
TTCTGCAGGGTTCCCAGGCCCCCGCTCCAGGGCCGGGCTGACCCGACTCGCTGGCGCTTCATGGAGAACTTCCAAAAGGTGGAAAAGATC
GGAGAGGGCACGTACGGAGTTGTGTACAAAGCCAGAAACAAGTTGACGGGAGAGGTGGTGGCGCTTAAGAAAATCCGCCTGGACACTGAG
ACTGAGGGTGTGCCCAGTACTGCCATCCGAGAGATCTCTCTGCTTAAGGAGCTTAACCATCCTAATATTGTCAAGCTGCTGGATGTCATT
CACACAGAAAATAAACTCTACCTGGTTTTTGAATTTCTGCACCAAGATCTCAAGAAATTCATGGATGCCTCTGCTCTCACTGGCATTCCT
CTTCCCCTCATCAAGAGCTATCTGTTCCAGCTGCTCCAGGGCCTAGCTTTCTGCCATTCTCATCGGGTCCTCCACCGAGACCTTAAACCT
CAGAATCTGCTTATTAACACAGAGGGGGCCATCAAGCTAGCAGACTTTGGACTAGCCAGAGCTTTTGGAGTCCCTGTTCGTACTTACACC
CATGAGGTGGTGACCCTGTGGTACCGAGCTCCTGAAATCCTCCTGGGCTGCAAATATTATTCCACAGCTGTGGACATCTGGAGCCTGGGC
TGCATCTTTGCTGAGATGATACCCTACAGACTCAAGGAGTCAGACAGTGAATTTGACAGCTTCAGCCAGGTCACTGAGTCACCAGTAGGA
CGAGAAGAGGAACCACATCTCCACATGGTTTCTAAGAAATACCGCAAGGTGACCATCAAATATTCCAAGCTAGGGCTGGAGGACTTTGAC
TTCAAACACTACAATAAGACCTTGTTTGCTGGATTAGAGCCCCACATTCCCAACGCCTACTGTAACTGCATGATCCAGGTGCTCTATTTC
CTGGAGCCTGTACGCTGTCTAATTCAAAACCACCTTTGCCAGAAGGAGTTCTGTCTGGCATGTGAGCTGGGCTTCCTGTTTCACATGTTG
GACCTCTCTCGTGGTGACCCTTGCCAGGGCAATAATTTTCTTCGGGCATTCCGTACTATTCCTGAGGCCTCAGCCCTCGGTCTAATCCTG
GCTGACTCAGATGAGGCCTCAGGCAAGGGCAATCTGGCCAGGCTCATTCAGAGGTGGAATCGCTTCATTCTCACTCAACTGCATCAAGAT
ATGCAGGAGCTGGAAATACCACAGGCTTATCGAGGTGCTGGAGGCAGCAGCTTTTGCTCATCGGGGGACTCTGTTATTGGGCAGCTCTTC
AGCTGTGAGATGGAGAACTGCAGCCTCTGCCGCTGTGGCAGTGAGACCGTGCGAGCCTCATCCACTCTGCTTTTCACACTCTCCTACCCT
GATGGTAGCAAAAGTGATAAAACTGGGAAGAACTATGACTTTGCTCAGGTGCTGAAGCGAAGCATCTGCCTGGACCAGAATACACAGGCC
TGGTGTGACACCTGTGAAAAGTACCAGCCCACGATTCAGACCCGCAACATCCGCCATCTGCCAGATATTCTTGTCATCAATTGTGAGGTG
AACAGCTCAAAAGAGGCTGATTTCTGGAGAATGCAGGCTGAGGTTGCCTTCAAGATGGCAGTAAAGAAACACGGTGGGGAAATCTCCAAG
AACAAGGAATTTGCTTTGGCTGATTGGAAGGAACTAGGGAGTCCAGAGGGTGTGCTGGTGTGTCCCTCCATTGAGGAGTTGAAGAACGTC
TGGCTTCCTTTCTCCATTCGCATGAAGATGACCAAAAACAAAGGGCTGGATGTTTGCAATTGGACTGATGGGGATGAGATGCAGTGGGGC
CCAGCCAGGGCAGAGGAGGAGCATGGTGTCTATGTGTATGACCTGATGGCTACTGTGGTACACATCCTGGACTCACGCACAGGGGGCAGC
CTGGTGGCTCACATCAAAGTTGGAGAGACCTACCACCAGCGCAAGGAGGGCGTTACTCACCAGCAGTGGTATCTGTTCAATGACTTTCTT
ATTGAACCTATTGATAAGCATGAAGCTGTGCAGTTTGACATGAATTGGAAAGTACCTGCAATCCTTTATTATGTCAAACGGAATCTCAAT
TCCAGATACAACCTGAACATCAAGAACCCTATTGAGGCAAGTGTCTTGCTGGCTGAAGCCTCGCTGGCACGGAAGCAGCGGAAAACACAT
ACTACCTTTATTCCACTGATGCTGAATGAGATGCCACAGATTGGGGACCTGGTGGGTCTGGATGCTGAGTTTGTCACCCTTAATGAGGAG
GAAGCAGAGTTACGCAGTGATGGTACCAAGTCTACCATTAAACCAAGCCAGATGTCAGTAGCCAGGATTACCTGTGTTCGGGGCCAGGGA
CCCAATGAGGGTATCCCCTTCATTGATGACTACATCTCTACCCAGGAGCAGGTGGTGGATTACTTGACTCAATACTCGGGTATAAAGCCT
GGTGACCTCGATGCCAAAATTTCCTCCAAGCACCTAACAACTCTCAAGTCTACCTACTTAAAGCTTCGTTTTCTCATTGACATTGGAGTC
AAGTTTGTGGGTCATGGCCTGCAGAAGGACTTCCGGGTCATCAACCTGATGGTGCCCAAGGACCAAGTCCTTGACACTGTCTACCTGTTC
CATATGCCCCGAAAACGAATGATTTCCCTGCGATTCCTTGCTTGGTACTTTCTGGACCTGAAGATTCAAGGGGAAACCCATGACAGTATT
GAGGATGCCCGCACAGCCCTTCAGCTGTACCGAAAGTATCTGGAGCTAAGCAAAAATGGCACTGAGCCTGAGTCTTTCCACAAGGTGCTC
AAGGGTCTTTATGAGAAGGGCAGAAAGATGGACTGGAAGGTGCCTGAGCCTGAGGGCCAAACAAGTCCCAAGAATGCAGCTGTCTTCTCC
TCAGTGCTGGCGCTCTGACTACCCTTCCCAAAGAACCACGGCCCTCTCCCTTTACTGTTCTATAGCCCCAGAACTGGGAGATGGCTTCCT
AAGTTGGCTATACCTTGTCCACTTCCAGTACTGGACGTGCTCAGGGTCTAGGGTCACAGATGGTGCTATTAATTGAACTGGAACACAGCA
GAATTGTTGCAAAGGTTCTAGGAGCCAGATTCATTCCTTCTTCATTCTTTGCAAAACAGTGGTACAGACATGGAGTCTAGAATTGACCCA
GATGGAAAGTAATTGGTATTCTTAATATCCTGGGTGACTAATATCCAGGCAGAGAAGCTCCTGGAACCATAACTGTAAGTTCCTAGCTGG
CTAGGGATTGAAGTCCTGGACAGTGACAGAGGATACCACAGTAGTTCAAGACTTAGCACAAGTCACCAACTGCTTCAGGGATACCTGGAG
GGGCCAGCAAGTAGAGTGTTGGTGGCCCAAGCAAACCAGTGTTGCCAATACCATTGCCAAAAGGGCCTTTGGATCCTGGACAAAGCTTGG
CTGCCGGCTTCATTTATTCCTGCTGATGGCTGAGAAGCATCTGTCTTCCATCCCACTTGCCTGTCCCAAGTTTTGTTCCATTTTTTAAAA
ATTTGTTGTAAACTGCATGTTTTATAAAATAAAAATAAAATATCGTTTGTTATTTATCTCATTAGAGAACTGCTAGTGTGGGTTCTCTGG
CTTCAGTCTTCCTCTCCTTCCTTTGAAGGTAAAGGTCCGGAATCCAAAGTTATGGATATGAAAGGGTATAATTAGGCCGGGCGCGGTGGC
TCACTTCTGTAATCCTAGCACTTTGGGAGGCAGAGGTGGGTGGAACACGAGGTCAGGAGTTAAAGACCAGCCTGACCAAGATGGTGAAAC
CCCGTCTCTACTAAAAATACAAAAATTAGCTGGGAGTGGTGGATGGCGACTGTAACCCTAGCTGAGGCAGAAAATTGCTTCAACCCGGGA
GGCGGAGGTTGCAGTGAGCCGAGATCACGCCACTGTATGCCAGCCTGGGCGATAGGGCGAGACTCCGTCTCAAAAAAAGGGGAAAAAGGT
ATAATTTATGCCTTTTCTGGGCAATGCTGGGTCTTTGCTATAGCTGCCCAGTACCCTAAGTCAGACTGAAGATGTACAGTATGGTTTCCG
TTAATTGTGTAAGCCGACAAACTACAGGTCCCAGGATAGCTTGAGACTTGTAGTTGCTCACAAAGATGGGTCCGGTGCTGCGGTGCTTCC
TGGGAGATGTAGTTTCCTGTGTATTGAAACCTGGACTGCTCGCTGGCCGGCAGCGCACCGTTTTGAAGGTCCTAGCCCACCTGGGCTGGC

>15243_15243_2_CDK2-PAN2_CDK2_chr12_56363360_ENST00000266970_PAN2_chr12_56719238_ENST00000425394_length(amino acids)=1001AA_BP=252
MAKLTRARGILRSIPTRGHGTGPCFPLLGPREPGSAFCRVPRPPLQGRADPTRWRFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKK
IRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL
HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMIPYRLKESDSEFDSFSQV
TESPVGREEEPHLHMVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELG
FLFHMLDLSRGDPCQGNNFLRAFRTIPEASALGLILADSDEASGKGNLARLIQRWNRFILTQLHQDMQELEIPQAYRGAGGSSFCSSGDS
VIGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPDGSKSDKTGKNYDFAQVLKRSICLDQNTQAWCDTCEKYQPTIQTRNIRHLPDIL
VINCEVNSSKEADFWRMQAEVAFKMAVKKHGGEISKNKEFALADWKELGSPEGVLVCPSIEELKNVWLPFSIRMKMTKNKGLDVCNWTDG
DEMQWGPARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKHEAVQFDMNWKVPAILYY
VKRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARIT
CVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVL
DTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPEGQTSPK

--------------------------------------------------------------
>15243_15243_3_CDK2-PAN2_CDK2_chr12_56363360_ENST00000266970_PAN2_chr12_56719238_ENST00000440411_length(transcript)=3739nt_BP=828nt
AACGCGGGAAGCAGGGGCGGGGCCTCTGGTGGCGGTCGGGAACTCGGTGGGAGGCGGCAACATTGTTTCAAGTTGGCCAAATTGACAAGA
GCGAGAGGTATACTGCGTTCCATCCCGACCCGGGGCCACGGTACTGGGCCCTGTTTCCCCCTCCTCGGCCCCCGAGAGCCAGGGTCCGCC
TTCTGCAGGGTTCCCAGGCCCCCGCTCCAGGGCCGGGCTGACCCGACTCGCTGGCGCTTCATGGAGAACTTCCAAAAGGTGGAAAAGATC
GGAGAGGGCACGTACGGAGTTGTGTACAAAGCCAGAAACAAGTTGACGGGAGAGGTGGTGGCGCTTAAGAAAATCCGCCTGGACACTGAG
ACTGAGGGTGTGCCCAGTACTGCCATCCGAGAGATCTCTCTGCTTAAGGAGCTTAACCATCCTAATATTGTCAAGCTGCTGGATGTCATT
CACACAGAAAATAAACTCTACCTGGTTTTTGAATTTCTGCACCAAGATCTCAAGAAATTCATGGATGCCTCTGCTCTCACTGGCATTCCT
CTTCCCCTCATCAAGAGCTATCTGTTCCAGCTGCTCCAGGGCCTAGCTTTCTGCCATTCTCATCGGGTCCTCCACCGAGACCTTAAACCT
CAGAATCTGCTTATTAACACAGAGGGGGCCATCAAGCTAGCAGACTTTGGACTAGCCAGAGCTTTTGGAGTCCCTGTTCGTACTTACACC
CATGAGGTGGTGACCCTGTGGTACCGAGCTCCTGAAATCCTCCTGGGCTGCAAATATTATTCCACAGCTGTGGACATCTGGAGCCTGGGC
TGCATCTTTGCTGAGATGATACCCTACAGACTCAAGGAGTCAGACAGTGAATTTGACAGCTTCAGCCAGGTCACTGAGTCACCAGTAGGA
CGAGAAGAGGAACCACATCTCCACATGGTTTCTAAGAAATACCGCAAGGTGACCATCAAATATTCCAAGCTAGGGCTGGAGGACTTTGAC
TTCAAACACTACAATAAGACCTTGTTTGCTGGATTAGAGCCCCACATTCCCAACGCCTACTGTAACTGCATGATCCAGGTGCTCTATTTC
CTGGAGCCTGTACGCTGTCTAATTCAAAACCACCTTTGCCAGAAGGAGTTCTGTCTGGCATGTGAGCTGGGCTTCCTGTTTCACATGTTG
GACCTCTCTCGTGGTGACCCTTGCCAGGGCAATAATTTTCTTCGGGCATTCCGTACTATTCCTGAGGCCTCAGCCCTCGGTCTAATCCTG
GCTGACTCAGATGAGGCCTCAGGCAAGGGCAATCTGGCCAGGCTCATTCAGAGGTGGAATCGCTTCATTCTCACTCAACTGCATCAAGAT
ATGCAGGAGCTGGAAATACCACAGGCTTATCGAGGTGCTGGAGGCAGCAGCTTTTGCTCATCGGGGGACTCTGTTATTGGGCAGCTCTTC
AGCTGTGAGATGGAGAACTGCAGCCTCTGCCGCTGTGGCAGTGAGACCGTGCGAGCCTCATCCACTCTGCTTTTCACACTCTCCTACCCT
GATGATAAAACTGGGAAGAACTATGACTTTGCTCAGGTGCTGAAGCGAAGCATCTGCCTGGACCAGAATACACAGGCCTGGTGTGACACC
TGTGAAAAGTACCAGCCCACGATTCAGACCCGCAACATCCGCCATCTGCCAGATATTCTTGTCATCAATTGTGAGGTGAACAGCTCAAAA
GAGGCTGATTTCTGGAGAATGCAGGCTGAGGTTGCCTTCAAGATGGCAGTAAAGAAACACGGTGGGGAAATCTCCAAGAACAAGGAATTT
GCTTTGGCTGATTGGAAGGAACTAGGGAGTCCAGAGGGTGTGCTGGTGTGTCCCTCCATTGAGGAGTTGAAGAACGTCTGGCTTCCTTTC
TCCATTCGCATGAAGATGACCAAAAACAAAGGGCTGGATGTTTGCAATTGGACTGATGGGGATGAGATGCAGTGGGGCCCAGCCAGGGCA
GAGGAGGAGCATGGTGTCTATGTGTATGACCTGATGGCTACTGTGGTACACATCCTGGACTCACGCACAGGGGGCAGCCTGGTGGCTCAC
ATCAAAGTTGGAGAGACCTACCACCAGCGCAAGGAGGGCGTTACTCACCAGCAGTGGTATCTGTTCAATGACTTTCTTATTGAACCTATT
GATAAGCATGAAGCTGTGCAGTTTGACATGAATTGGAAAGTACCTGCAATCCTTTATTATGTCAAACGGAATCTCAATTCCAGATACAAC
CTGAACATCAAGAACCCTATTGAGGCAAGTGTCTTGCTGGCTGAAGCCTCGCTGGCACGGAAGCAGCGGAAAACACATACTACCTTTATT
CCACTGATGCTGAATGAGATGCCACAGATTGGGGACCTGGTGGGTCTGGATGCTGAGTTTGTCACCCTTAATGAGGAGGAAGCAGAGTTA
CGCAGTGATGGTACCAAGTCTACCATTAAACCAAGCCAGATGTCAGTAGCCAGGATTACCTGTGTTCGGGGCCAGGGACCCAATGAGGGT
ATCCCCTTCATTGATGACTACATCTCTACCCAGGAGCAGGTGGTGGATTACTTGACTCAATACTCGGGTATAAAGCCTGGTGACCTCGAT
GCCAAAATTTCCTCCAAGCACCTAACAACTCTCAAGTCTACCTACTTAAAGCTTCGTTTTCTCATTGACATTGGAGTCAAGTTTGTGGGT
CATGGCCTGCAGAAGGACTTCCGGGTCATCAACCTGATGGTGCCCAAGGACCAAGTCCTTGACACTGTCTACCTGTTCCATATGCCCCGA
AAACGAATGATTTCCCTGCGATTCCTTGCTTGGTACTTTCTGGACCTGAAGATTCAAGGGGAAACCCATGACAGTATTGAGGATGCCCGC
ACAGCCCTTCAGCTGTACCGAAAGTATCTGGAGCTAAGCAAAAATGGCACTGAGCCTGAGTCTTTCCACAAGGTGCTCAAGGGTCTTTAT
GAGAAGGGCAGAAAGATGGACTGGAAGGTGCCTGAGCCTGAGGGCCAAACAAGTCCCAAGAATGCAGCTGTCTTCTCCTCAGTGCTGGCG
CTCTGACTACCCTTCCCAAAGAACCACGGCCCTCTCCCTTTACTGTTCTATAGCCCCAGAACTGGGAGATGGCTTCCTAAGTTGGCTATA
CCTTGTCCACTTCCAGTACTGGACGTGCTCAGGGTCTAGGGTCACAGATGGTGCTATTAATTGAACTGGAACACAGCAGAATTGTTGCAA
AGGTTCTAGGAGCCAGATTCATTCCTTCTTCATTCTTTGCAAAACAGTGGTACAGACATGGAGTCTAGAATTGACCCAGATGGAAAGTAA
TTGGTATTCTTAATATCCTGGGTGACTAATATCCAGGCAGAGAAGCTCCTGGAACCATAACTGTAAGTTCCTAGCTGGCTAGGGATTGAA
GTCCTGGACAGTGACAGAGGATACCACAGTAGTTCAAGACTTAGCACAAGTCACCAACTGCTTCAGGGATACCTGGAGGGGCCAGCAAGT
AGAGTGTTGGTGGCCCAAGCAAACCAGTGTTGCCAATACCATTGCCAAAAGGGCCTTTGGATCCTGGACAAAGCTTGGCTGCCGGCTTCA
TTTATTCCTGCTGATGGCTGAGAAGCATCTGTCTTCCATCCCACTTGCCTGTCCCAAGTTTTGTTCCATTTTTTAAAAATTTGTTGTAAA

>15243_15243_3_CDK2-PAN2_CDK2_chr12_56363360_ENST00000266970_PAN2_chr12_56719238_ENST00000440411_length(amino acids)=997AA_BP=252
MAKLTRARGILRSIPTRGHGTGPCFPLLGPREPGSAFCRVPRPPLQGRADPTRWRFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKK
IRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL
HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMIPYRLKESDSEFDSFSQV
TESPVGREEEPHLHMVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELG
FLFHMLDLSRGDPCQGNNFLRAFRTIPEASALGLILADSDEASGKGNLARLIQRWNRFILTQLHQDMQELEIPQAYRGAGGSSFCSSGDS
VIGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPDDKTGKNYDFAQVLKRSICLDQNTQAWCDTCEKYQPTIQTRNIRHLPDILVINC
EVNSSKEADFWRMQAEVAFKMAVKKHGGEISKNKEFALADWKELGSPEGVLVCPSIEELKNVWLPFSIRMKMTKNKGLDVCNWTDGDEMQ
WGPARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKHEAVQFDMNWKVPAILYYVKRN
LNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRG
QGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVY
LFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPEGQTSPKNAAV

--------------------------------------------------------------
>15243_15243_4_CDK2-PAN2_CDK2_chr12_56363360_ENST00000266970_PAN2_chr12_56719238_ENST00000548043_length(transcript)=3740nt_BP=828nt
AACGCGGGAAGCAGGGGCGGGGCCTCTGGTGGCGGTCGGGAACTCGGTGGGAGGCGGCAACATTGTTTCAAGTTGGCCAAATTGACAAGA
GCGAGAGGTATACTGCGTTCCATCCCGACCCGGGGCCACGGTACTGGGCCCTGTTTCCCCCTCCTCGGCCCCCGAGAGCCAGGGTCCGCC
TTCTGCAGGGTTCCCAGGCCCCCGCTCCAGGGCCGGGCTGACCCGACTCGCTGGCGCTTCATGGAGAACTTCCAAAAGGTGGAAAAGATC
GGAGAGGGCACGTACGGAGTTGTGTACAAAGCCAGAAACAAGTTGACGGGAGAGGTGGTGGCGCTTAAGAAAATCCGCCTGGACACTGAG
ACTGAGGGTGTGCCCAGTACTGCCATCCGAGAGATCTCTCTGCTTAAGGAGCTTAACCATCCTAATATTGTCAAGCTGCTGGATGTCATT
CACACAGAAAATAAACTCTACCTGGTTTTTGAATTTCTGCACCAAGATCTCAAGAAATTCATGGATGCCTCTGCTCTCACTGGCATTCCT
CTTCCCCTCATCAAGAGCTATCTGTTCCAGCTGCTCCAGGGCCTAGCTTTCTGCCATTCTCATCGGGTCCTCCACCGAGACCTTAAACCT
CAGAATCTGCTTATTAACACAGAGGGGGCCATCAAGCTAGCAGACTTTGGACTAGCCAGAGCTTTTGGAGTCCCTGTTCGTACTTACACC
CATGAGGTGGTGACCCTGTGGTACCGAGCTCCTGAAATCCTCCTGGGCTGCAAATATTATTCCACAGCTGTGGACATCTGGAGCCTGGGC
TGCATCTTTGCTGAGATGATACCCTACAGACTCAAGGAGTCAGACAGTGAATTTGACAGCTTCAGCCAGGTCACTGAGTCACCAGTAGGA
CGAGAAGAGGAACCACATCTCCACATGGTTTCTAAGAAATACCGCAAGGTGACCATCAAATATTCCAAGCTAGGGCTGGAGGACTTTGAC
TTCAAACACTACAATAAGACCTTGTTTGCTGGATTAGAGCCCCACATTCCCAACGCCTACTGTAACTGCATGATCCAGGTGCTCTATTTC
CTGGAGCCTGTACGCTGTCTAATTCAAAACCACCTTTGCCAGAAGGAGTTCTGTCTGGCATGTGAGCTGGGCTTCCTGTTTCACATGTTG
GACCTCTCTCGTGGTGACCCTTGCCAGGGCAATAATTTTCTTCGGGCATTCCGTACTATTCCTGAGGCCTCAGCCCTCGGTCTAATCCTG
GCTGACTCAGATGAGGCCTCAGGCAAGGGCAATCTGGCCAGGCTCATTCAGAGGTGGAATCGCTTCATTCTCACTCAACTGCATCAAGAT
ATGCAGGAGCTGGAAATACCACAGGCTTATCGAGGTGCTGGAGGCAGCAGCTTTTGCTCATCGGGGGACTCTGTTATTGGGCAGCTCTTC
AGCTGTGAGATGGAGAACTGCAGCCTCTGCCGCTGTGGCAGTGAGACCGTGCGAGCCTCATCCACTCTGCTTTTCACACTCTCCTACCCT
GATGGTAGCAAAAGTGATAAAACTGGGAAGAACTATGACTTTGCTCAGGTGCTGAAGCGAAGCATCTGCCTGGACCAGAATACACAGGCC
TGGTGTGACACCTGTGAAAAGTACCAGCCCACGATTCAGACCCGCAACATCCGCCATCTGCCAGATATTCTTGTCATCAATTGTGAGGTG
AACAGCTCAAAAGAGGCTGATTTCTGGAGAATGCAGGCTGAGGTTGCCTTCAAGATGGCAGTAAAGAAACACGGTGGGGAAATCTCCAAG
AACAAGGAATTTGCTTTGGCTGATTGGAAGGAACTAGGGAGTCCAGAGGGTGTGCTGGTGTGTCCCTCCATTGAGGAGTTGAAGAACGTC
TGGCTTCCTTTCTCCATTCGCATGAAGATGACCAAAAACAAAGGGCTGGATGTTTGCAATTGGACTGATGGGGATGAGATGCAGTGGGGC
CCAGCCAGGGCAGAGGAGGAGCATGGTGTCTATGTGTATGACCTGATGGCTACTGTGGTACACATCCTGGACTCACGCACAGGGGGCAGC
CTGGTGGCTCACATCAAAGTTGGAGAGACCTACCACCAGCGCAAGGAGGGCGTTACTCACCAGCAGTGGTATCTGTTCAATGACTTTCTT
ATTGAACCTATTGATAAGCATGAAGCTGTGCAGTTTGACATGAATTGGAAAGTACCTGCAATCCTTTATTATGTCAAACGGAATCTCAAT
TCCAGATACAACCTGAACATCAAGAACCCTATTGAGGCAAGTGTCTTGCTGGCTGAAGCCTCGCTGGCACGGAAGCAGCGGAAAACACAT
ACTACCTTTATTCCACTGATGCTGAATGAGATGCCACAGATTGGGGACCTGGTGGGTCTGGATGCTGAGTTTGTCACCCTTAATGAGGAG
GAAGCAGAGTTACGCAGTGATGGTACCAAGTCTACCATTAAACCAAGCCAGATGTCAGTAGCCAGGATTACCTGTGTTCGGGGCCAGGGA
CCCAATGAGGGTATCCCCTTCATTGATGACTACATCTCTACCCAGGAGCAGGTGGTGGATTACTTGACTCAATACTCGGGTATAAAGCCT
GGTGACCTCGATGCCAAAATTTCCTCCAAGCACCTAACAACTCTCAAGTCTACCTACTTAAAGCTTCGTTTTCTCATTGACATTGGAGTC
AAGTTTGTGGGTCATGGCCTGCAGAAGGACTTCCGGGTCATCAACCTGATGGTGCCCAAGGACCAAGTCCTTGACACTGTCTACCTGTTC
CATATGCCCCGAAAACGAATGATTTCCCTGCGATTCCTTGCTTGGTACTTTCTGGACCTGAAGATTCAAGGGGAAACCCATGACAGTATT
GAGGATGCCCGCACAGCCCTTCAGCTGTACCGAAAGTATCTGGAGCTAAGCAAAAATGGCACTGAGCCTGAGTCTTTCCACAAGGTGCTC
AAGGGTCTTTATGAGAAGGGCAGAAAGATGGACTGGAAGGTGCCTGAGCCTGAGGGCCAAACAAGTCCCAAGAATGCAGCTGTCTTCTCC
TCAGTGCTGGCGCTCTGACTACCCTTCCCAAAGAACCACGGCCCTCTCCCTTTACTGTTCTATAGCCCCAGAACTGGGAGATGGCTTCCT
AAGTTGGCTATACCTTGTCCACTTCCAGTACTGGACGTGCTCAGGGTCTAGGGTCACAGATGGTGCTATTAATTGAACTGGAACACAGCA
GAATTGTTGCAAAGGTTCTAGGAGCCAGATTCATTCCTTCTTCATTCTTTGCAAAACAGTGGTACAGACATGGAGTCTAGAATTGACCCA
GATGGAAAGTAATTGGTATTCTTAATATCCTGGGTGACTAATATCCAGGCAGAGAAGCTCCTGGAACCATAACTGTAAGTTCCTAGCTGG
CTAGGGATTGAAGTCCTGGACAGTGACAGAGGATACCACAGTAGTTCAAGACTTAGCACAAGTCACCAACTGCTTCAGGGATACCTGGAG
GGGCCAGCAAGTAGAGTGTTGGTGGCCCAAGCAAACCAGTGTTGCCAATACCATTGCCAAAAGGGCCTTTGGATCCTGGACAAAGCTTGG
CTGCCGGCTTCATTTATTCCTGCTGATGGCTGAGAAGCATCTGTCTTCCATCCCACTTGCCTGTCCCAAGTTTTGTTCCATTTTTTAAAA

>15243_15243_4_CDK2-PAN2_CDK2_chr12_56363360_ENST00000266970_PAN2_chr12_56719238_ENST00000548043_length(amino acids)=1001AA_BP=252
MAKLTRARGILRSIPTRGHGTGPCFPLLGPREPGSAFCRVPRPPLQGRADPTRWRFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKK
IRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL
HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMIPYRLKESDSEFDSFSQV
TESPVGREEEPHLHMVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELG
FLFHMLDLSRGDPCQGNNFLRAFRTIPEASALGLILADSDEASGKGNLARLIQRWNRFILTQLHQDMQELEIPQAYRGAGGSSFCSSGDS
VIGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPDGSKSDKTGKNYDFAQVLKRSICLDQNTQAWCDTCEKYQPTIQTRNIRHLPDIL
VINCEVNSSKEADFWRMQAEVAFKMAVKKHGGEISKNKEFALADWKELGSPEGVLVCPSIEELKNVWLPFSIRMKMTKNKGLDVCNWTDG
DEMQWGPARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKHEAVQFDMNWKVPAILYY
VKRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARIT
CVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVL
DTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPEGQTSPK

--------------------------------------------------------------
>15243_15243_5_CDK2-PAN2_CDK2_chr12_56363360_ENST00000553376_PAN2_chr12_56719238_ENST00000257931_length(transcript)=3695nt_BP=776nt
GGCGGCAACATTGTTTCAAGTTGGCCAAATTGACAAGAGCGAGAGGTATACTGCGTTCCATCCCGACCCGGGGCCACGGTACTGGGCCCT
GTTTCCCCCTCCTCGGCCCCCGAGAGCCAGGGTCCGCCTTCTGCAGGGTTCCCAGGCCCCCGCTCCAGGGCCGGGCTGACCCGACTCGCT
GGCGCTTCATGGAGAACTTCCAAAAGGTGGAAAAGATCGGAGAGGGCACGTACGGAGTTGTGTACAAAGCCAGAAACAAGTTGACGGGAG
AGGTGGTGGCGCTTAAGAAAATCCGCCTGGACACTGAGACTGAGGGTGTGCCCAGTACTGCCATCCGAGAGATCTCTCTGCTTAAGGAGC
TTAACCATCCTAATATTGTCAAGCTGCTGGATGTCATTCACACAGAAAATAAACTCTACCTGGTTTTTGAATTTCTGCACCAAGATCTCA
AGAAATTCATGGATGCCTCTGCTCTCACTGGCATTCCTCTTCCCCTCATCAAGAGCTATCTGTTCCAGCTGCTCCAGGGCCTAGCTTTCT
GCCATTCTCATCGGGTCCTCCACCGAGACCTTAAACCTCAGAATCTGCTTATTAACACAGAGGGGGCCATCAAGCTAGCAGACTTTGGAC
TAGCCAGAGCTTTTGGAGTCCCTGTTCGTACTTACACCCATGAGGTGGTGACCCTGTGGTACCGAGCTCCTGAAATCCTCCTGGGCTGCA
AATATTATTCCACAGCTGTGGACATCTGGAGCCTGGGCTGCATCTTTGCTGAGATGATACCCTACAGACTCAAGGAGTCAGACAGTGAAT
TTGACAGCTTCAGCCAGGTCACTGAGTCACCAGTAGGACGAGAAGAGGAACCACATCTCCACATGGTTTCTAAGAAATACCGCAAGGTGA
CCATCAAATATTCCAAGCTAGGGCTGGAGGACTTTGACTTCAAACACTACAATAAGACCTTGTTTGCTGGATTAGAGCCCCACATTCCCA
ACGCCTACTGTAACTGCATGATCCAGGTGCTCTATTTCCTGGAGCCTGTACGCTGTCTAATTCAAAACCACCTTTGCCAGAAGGAGTTCT
GTCTGGCATGTGAGCTGGGCTTCCTGTTTCACATGTTGGACCTCTCTCGTGGTGACCCTTGCCAGGGCAATAATTTTCTTCGGGCATTCC
GTACTATTCCTGAGGCCTCAGCCCTCGGTCTAATCCTGGCTGACTCAGATGAGGCCTCAGGCAAGGGCAATCTGGCCAGGCTCATTCAGA
GGTGGAATCGCTTCATTCTCACTCAACTGCATCAAGATATGCAGGAGCTGGAAATACCACAGGCTTATCGAGGTGCTGGAGGCAGCTTTT
GCTCATCGGGGGACTCTGTTATTGGGCAGCTCTTCAGCTGTGAGATGGAGAACTGCAGCCTCTGCCGCTGTGGCAGTGAGACCGTGCGAG
CCTCATCCACTCTGCTTTTCACACTCTCCTACCCTGATGGTAGCAAAAGTGATAAAACTGGGAAGAACTATGACTTTGCTCAGGTGCTGA
AGCGAAGCATCTGCCTGGACCAGAATACACAGGCCTGGTGTGACACCTGTGAAAAGTACCAGCCCACGATTCAGACCCGCAACATCCGCC
ATCTGCCAGATATTCTTGTCATCAATTGTGAGGTGAACAGCTCAAAAGAGGCTGATTTCTGGAGAATGCAGGCTGAGGTTGCCTTCAAGA
TGGCAGTAAAGAAACACGGTGGGGAAATCTCCAAGAACAAGGAATTTGCTTTGGCTGATTGGAAGGAACTAGGGAGTCCAGAGGGTGTGC
TGGTGTGTCCCTCCATTGAGGAGTTGAAGAACGTCTGGCTTCCTTTCTCCATTCGCATGAAGATGACCAAAAACAAAGGGCTGGATGTTT
GCAATTGGACTGATGGGGATGAGATGCAGTGGGGCCCAGCCAGGGCAGAGGAGGAGCATGGTGTCTATGTGTATGACCTGATGGCTACTG
TGGTACACATCCTGGACTCACGCACAGGGGGCAGCCTGGTGGCTCACATCAAAGTTGGAGAGACCTACCACCAGCGCAAGGAGGGCGTTA
CTCACCAGCAGTGGTATCTGTTCAATGACTTTCTTATTGAACCTATTGATAAGCATGAAGCTGTGCAGTTTGACATGAATTGGAAAGTAC
CTGCAATCCTTTATTATGTCAAACGGAATCTCAATTCCAGATACAACCTGAACATCAAGAACCCTATTGAGGCAAGTGTCTTGCTGGCTG
AAGCCTCGCTGGCACGGAAGCAGCGGAAAACACATACTACCTTTATTCCACTGATGCTGAATGAGATGCCACAGATTGGGGACCTGGTGG
GTCTGGATGCTGAGTTTGTCACCCTTAATGAGGAGGAAGCAGAGTTACGCAGTGATGGTACCAAGTCTACCATTAAACCAAGCCAGATGT
CAGTAGCCAGGATTACCTGTGTTCGGGGCCAGGGACCCAATGAGGGTATCCCCTTCATTGATGACTACATCTCTACCCAGGAGCAGGTGG
TGGATTACTTGACTCAATACTCGGGTATAAAGCCTGGTGACCTCGATGCCAAAATTTCCTCCAAGCACCTAACAACTCTCAAGTCTACCT
ACTTAAAGCTTCGTTTTCTCATTGACATTGGAGTCAAGTTTGTGGGTCATGGCCTGCAGAAGGACTTCCGGGTCATCAACCTGATGGTGC
CCAAGGACCAAGTCCTTGACACTGTCTACCTGTTCCATATGCCCCGAAAACGAATGATTTCCCTGCGATTCCTTGCTTGGTACTTTCTGG
ACCTGAAGATTCAAGGGGAAACCCATGACAGTATTGAGGATGCCCGCACAGCCCTTCAGCTGTACCGAAAGTATCTGGAGCTAAGCAAAA
ATGGCACTGAGCCTGAGTCTTTCCACAAGGTGCTCAAGGGTCTTTATGAGAAGGGCAGAAAGATGGACTGGAAGGTGCCTGAGCCTGAGG
GCCAAACAAGTCCCAAGAATGCAGCTGTCTTCTCCTCAGTGCTGGCGCTCTGACTACCCTTCCCAAAGAACCACGGCCCTCTCCCTTTAC
TGTTCTATAGCCCCAGAACTGGGAGATGGCTTCCTAAGTTGGCTATACCTTGTCCACTTCCAGTACTGGACGTGCTCAGGGTCTAGGGTC
ACAGATGGTGCTATTAATTGAACTGGAACACAGCAGAATTGTTGCAAAGGTTCTAGGAGCCAGATTCATTCCTTCTTCATTCTTTGCAAA
ACAGTGGTACAGACATGGAGTCTAGAATTGACCCAGATGGAAAGTAATTGGTATTCTTAATATCCTGGGTGACTAATATCCAGGCAGAGA
AGCTCCTGGAACCATAACTGTAAGTTCCTAGCTGGCTAGGGATTGAAGTCCTGGACAGTGACAGAGGATACCACAGTAGTTCAAGACTTA
GCACAAGTCACCAACTGCTTCAGGGATACCTGGAGGGGCCAGCAAGTAGAGTGTTGGTGGCCCAAGCAAACCAGTGTTGCCAATACCATT
GCCAAAAGGGCCTTTGGATCCTGGACAAAGCTTGGCTGCCGGCTTCATTTATTCCTGCTGATGGCTGAGAAGCATCTGTCTTCCATCCCA
CTTGCCTGTCCCAAGTTTTGTTCCATTTTTTAAAAATTTGTTGTAAACTGCATGTTTTATAAAATAAAAATAAAATATCGTTTGTTATTT

>15243_15243_5_CDK2-PAN2_CDK2_chr12_56363360_ENST00000553376_PAN2_chr12_56719238_ENST00000257931_length(amino acids)=1000AA_BP=252
MAKLTRARGILRSIPTRGHGTGPCFPLLGPREPGSAFCRVPRPPLQGRADPTRWRFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKK
IRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL
HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMIPYRLKESDSEFDSFSQV
TESPVGREEEPHLHMVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELG
FLFHMLDLSRGDPCQGNNFLRAFRTIPEASALGLILADSDEASGKGNLARLIQRWNRFILTQLHQDMQELEIPQAYRGAGGSFCSSGDSV
IGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPDGSKSDKTGKNYDFAQVLKRSICLDQNTQAWCDTCEKYQPTIQTRNIRHLPDILV
INCEVNSSKEADFWRMQAEVAFKMAVKKHGGEISKNKEFALADWKELGSPEGVLVCPSIEELKNVWLPFSIRMKMTKNKGLDVCNWTDGD
EMQWGPARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKHEAVQFDMNWKVPAILYYV
KRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITC
VRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLD
TVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPEGQTSPKN

--------------------------------------------------------------
>15243_15243_6_CDK2-PAN2_CDK2_chr12_56363360_ENST00000553376_PAN2_chr12_56719238_ENST00000425394_length(transcript)=4412nt_BP=776nt
GGCGGCAACATTGTTTCAAGTTGGCCAAATTGACAAGAGCGAGAGGTATACTGCGTTCCATCCCGACCCGGGGCCACGGTACTGGGCCCT
GTTTCCCCCTCCTCGGCCCCCGAGAGCCAGGGTCCGCCTTCTGCAGGGTTCCCAGGCCCCCGCTCCAGGGCCGGGCTGACCCGACTCGCT
GGCGCTTCATGGAGAACTTCCAAAAGGTGGAAAAGATCGGAGAGGGCACGTACGGAGTTGTGTACAAAGCCAGAAACAAGTTGACGGGAG
AGGTGGTGGCGCTTAAGAAAATCCGCCTGGACACTGAGACTGAGGGTGTGCCCAGTACTGCCATCCGAGAGATCTCTCTGCTTAAGGAGC
TTAACCATCCTAATATTGTCAAGCTGCTGGATGTCATTCACACAGAAAATAAACTCTACCTGGTTTTTGAATTTCTGCACCAAGATCTCA
AGAAATTCATGGATGCCTCTGCTCTCACTGGCATTCCTCTTCCCCTCATCAAGAGCTATCTGTTCCAGCTGCTCCAGGGCCTAGCTTTCT
GCCATTCTCATCGGGTCCTCCACCGAGACCTTAAACCTCAGAATCTGCTTATTAACACAGAGGGGGCCATCAAGCTAGCAGACTTTGGAC
TAGCCAGAGCTTTTGGAGTCCCTGTTCGTACTTACACCCATGAGGTGGTGACCCTGTGGTACCGAGCTCCTGAAATCCTCCTGGGCTGCA
AATATTATTCCACAGCTGTGGACATCTGGAGCCTGGGCTGCATCTTTGCTGAGATGATACCCTACAGACTCAAGGAGTCAGACAGTGAAT
TTGACAGCTTCAGCCAGGTCACTGAGTCACCAGTAGGACGAGAAGAGGAACCACATCTCCACATGGTTTCTAAGAAATACCGCAAGGTGA
CCATCAAATATTCCAAGCTAGGGCTGGAGGACTTTGACTTCAAACACTACAATAAGACCTTGTTTGCTGGATTAGAGCCCCACATTCCCA
ACGCCTACTGTAACTGCATGATCCAGGTGCTCTATTTCCTGGAGCCTGTACGCTGTCTAATTCAAAACCACCTTTGCCAGAAGGAGTTCT
GTCTGGCATGTGAGCTGGGCTTCCTGTTTCACATGTTGGACCTCTCTCGTGGTGACCCTTGCCAGGGCAATAATTTTCTTCGGGCATTCC
GTACTATTCCTGAGGCCTCAGCCCTCGGTCTAATCCTGGCTGACTCAGATGAGGCCTCAGGCAAGGGCAATCTGGCCAGGCTCATTCAGA
GGTGGAATCGCTTCATTCTCACTCAACTGCATCAAGATATGCAGGAGCTGGAAATACCACAGGCTTATCGAGGTGCTGGAGGCAGCAGCT
TTTGCTCATCGGGGGACTCTGTTATTGGGCAGCTCTTCAGCTGTGAGATGGAGAACTGCAGCCTCTGCCGCTGTGGCAGTGAGACCGTGC
GAGCCTCATCCACTCTGCTTTTCACACTCTCCTACCCTGATGGTAGCAAAAGTGATAAAACTGGGAAGAACTATGACTTTGCTCAGGTGC
TGAAGCGAAGCATCTGCCTGGACCAGAATACACAGGCCTGGTGTGACACCTGTGAAAAGTACCAGCCCACGATTCAGACCCGCAACATCC
GCCATCTGCCAGATATTCTTGTCATCAATTGTGAGGTGAACAGCTCAAAAGAGGCTGATTTCTGGAGAATGCAGGCTGAGGTTGCCTTCA
AGATGGCAGTAAAGAAACACGGTGGGGAAATCTCCAAGAACAAGGAATTTGCTTTGGCTGATTGGAAGGAACTAGGGAGTCCAGAGGGTG
TGCTGGTGTGTCCCTCCATTGAGGAGTTGAAGAACGTCTGGCTTCCTTTCTCCATTCGCATGAAGATGACCAAAAACAAAGGGCTGGATG
TTTGCAATTGGACTGATGGGGATGAGATGCAGTGGGGCCCAGCCAGGGCAGAGGAGGAGCATGGTGTCTATGTGTATGACCTGATGGCTA
CTGTGGTACACATCCTGGACTCACGCACAGGGGGCAGCCTGGTGGCTCACATCAAAGTTGGAGAGACCTACCACCAGCGCAAGGAGGGCG
TTACTCACCAGCAGTGGTATCTGTTCAATGACTTTCTTATTGAACCTATTGATAAGCATGAAGCTGTGCAGTTTGACATGAATTGGAAAG
TACCTGCAATCCTTTATTATGTCAAACGGAATCTCAATTCCAGATACAACCTGAACATCAAGAACCCTATTGAGGCAAGTGTCTTGCTGG
CTGAAGCCTCGCTGGCACGGAAGCAGCGGAAAACACATACTACCTTTATTCCACTGATGCTGAATGAGATGCCACAGATTGGGGACCTGG
TGGGTCTGGATGCTGAGTTTGTCACCCTTAATGAGGAGGAAGCAGAGTTACGCAGTGATGGTACCAAGTCTACCATTAAACCAAGCCAGA
TGTCAGTAGCCAGGATTACCTGTGTTCGGGGCCAGGGACCCAATGAGGGTATCCCCTTCATTGATGACTACATCTCTACCCAGGAGCAGG
TGGTGGATTACTTGACTCAATACTCGGGTATAAAGCCTGGTGACCTCGATGCCAAAATTTCCTCCAAGCACCTAACAACTCTCAAGTCTA
CCTACTTAAAGCTTCGTTTTCTCATTGACATTGGAGTCAAGTTTGTGGGTCATGGCCTGCAGAAGGACTTCCGGGTCATCAACCTGATGG
TGCCCAAGGACCAAGTCCTTGACACTGTCTACCTGTTCCATATGCCCCGAAAACGAATGATTTCCCTGCGATTCCTTGCTTGGTACTTTC
TGGACCTGAAGATTCAAGGGGAAACCCATGACAGTATTGAGGATGCCCGCACAGCCCTTCAGCTGTACCGAAAGTATCTGGAGCTAAGCA
AAAATGGCACTGAGCCTGAGTCTTTCCACAAGGTGCTCAAGGGTCTTTATGAGAAGGGCAGAAAGATGGACTGGAAGGTGCCTGAGCCTG
AGGGCCAAACAAGTCCCAAGAATGCAGCTGTCTTCTCCTCAGTGCTGGCGCTCTGACTACCCTTCCCAAAGAACCACGGCCCTCTCCCTT
TACTGTTCTATAGCCCCAGAACTGGGAGATGGCTTCCTAAGTTGGCTATACCTTGTCCACTTCCAGTACTGGACGTGCTCAGGGTCTAGG
GTCACAGATGGTGCTATTAATTGAACTGGAACACAGCAGAATTGTTGCAAAGGTTCTAGGAGCCAGATTCATTCCTTCTTCATTCTTTGC
AAAACAGTGGTACAGACATGGAGTCTAGAATTGACCCAGATGGAAAGTAATTGGTATTCTTAATATCCTGGGTGACTAATATCCAGGCAG
AGAAGCTCCTGGAACCATAACTGTAAGTTCCTAGCTGGCTAGGGATTGAAGTCCTGGACAGTGACAGAGGATACCACAGTAGTTCAAGAC
TTAGCACAAGTCACCAACTGCTTCAGGGATACCTGGAGGGGCCAGCAAGTAGAGTGTTGGTGGCCCAAGCAAACCAGTGTTGCCAATACC
ATTGCCAAAAGGGCCTTTGGATCCTGGACAAAGCTTGGCTGCCGGCTTCATTTATTCCTGCTGATGGCTGAGAAGCATCTGTCTTCCATC
CCACTTGCCTGTCCCAAGTTTTGTTCCATTTTTTAAAAATTTGTTGTAAACTGCATGTTTTATAAAATAAAAATAAAATATCGTTTGTTA
TTTATCTCATTAGAGAACTGCTAGTGTGGGTTCTCTGGCTTCAGTCTTCCTCTCCTTCCTTTGAAGGTAAAGGTCCGGAATCCAAAGTTA
TGGATATGAAAGGGTATAATTAGGCCGGGCGCGGTGGCTCACTTCTGTAATCCTAGCACTTTGGGAGGCAGAGGTGGGTGGAACACGAGG
TCAGGAGTTAAAGACCAGCCTGACCAAGATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGAGTGGTGGATGGCGACTG
TAACCCTAGCTGAGGCAGAAAATTGCTTCAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCACGCCACTGTATGCCAGCCTGGGCGA
TAGGGCGAGACTCCGTCTCAAAAAAAGGGGAAAAAGGTATAATTTATGCCTTTTCTGGGCAATGCTGGGTCTTTGCTATAGCTGCCCAGT
ACCCTAAGTCAGACTGAAGATGTACAGTATGGTTTCCGTTAATTGTGTAAGCCGACAAACTACAGGTCCCAGGATAGCTTGAGACTTGTA
GTTGCTCACAAAGATGGGTCCGGTGCTGCGGTGCTTCCTGGGAGATGTAGTTTCCTGTGTATTGAAACCTGGACTGCTCGCTGGCCGGCA
GCGCACCGTTTTGAAGGTCCTAGCCCACCTGGGCTGGCTCACGCGCACGACTAGCCGCTCCCATACAGCACGCCCGGACTCTGTCGTCGC

>15243_15243_6_CDK2-PAN2_CDK2_chr12_56363360_ENST00000553376_PAN2_chr12_56719238_ENST00000425394_length(amino acids)=1001AA_BP=252
MAKLTRARGILRSIPTRGHGTGPCFPLLGPREPGSAFCRVPRPPLQGRADPTRWRFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKK
IRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL
HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMIPYRLKESDSEFDSFSQV
TESPVGREEEPHLHMVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELG
FLFHMLDLSRGDPCQGNNFLRAFRTIPEASALGLILADSDEASGKGNLARLIQRWNRFILTQLHQDMQELEIPQAYRGAGGSSFCSSGDS
VIGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPDGSKSDKTGKNYDFAQVLKRSICLDQNTQAWCDTCEKYQPTIQTRNIRHLPDIL
VINCEVNSSKEADFWRMQAEVAFKMAVKKHGGEISKNKEFALADWKELGSPEGVLVCPSIEELKNVWLPFSIRMKMTKNKGLDVCNWTDG
DEMQWGPARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKHEAVQFDMNWKVPAILYY
VKRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARIT
CVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVL
DTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPEGQTSPK

--------------------------------------------------------------
>15243_15243_7_CDK2-PAN2_CDK2_chr12_56363360_ENST00000553376_PAN2_chr12_56719238_ENST00000440411_length(transcript)=3687nt_BP=776nt
GGCGGCAACATTGTTTCAAGTTGGCCAAATTGACAAGAGCGAGAGGTATACTGCGTTCCATCCCGACCCGGGGCCACGGTACTGGGCCCT
GTTTCCCCCTCCTCGGCCCCCGAGAGCCAGGGTCCGCCTTCTGCAGGGTTCCCAGGCCCCCGCTCCAGGGCCGGGCTGACCCGACTCGCT
GGCGCTTCATGGAGAACTTCCAAAAGGTGGAAAAGATCGGAGAGGGCACGTACGGAGTTGTGTACAAAGCCAGAAACAAGTTGACGGGAG
AGGTGGTGGCGCTTAAGAAAATCCGCCTGGACACTGAGACTGAGGGTGTGCCCAGTACTGCCATCCGAGAGATCTCTCTGCTTAAGGAGC
TTAACCATCCTAATATTGTCAAGCTGCTGGATGTCATTCACACAGAAAATAAACTCTACCTGGTTTTTGAATTTCTGCACCAAGATCTCA
AGAAATTCATGGATGCCTCTGCTCTCACTGGCATTCCTCTTCCCCTCATCAAGAGCTATCTGTTCCAGCTGCTCCAGGGCCTAGCTTTCT
GCCATTCTCATCGGGTCCTCCACCGAGACCTTAAACCTCAGAATCTGCTTATTAACACAGAGGGGGCCATCAAGCTAGCAGACTTTGGAC
TAGCCAGAGCTTTTGGAGTCCCTGTTCGTACTTACACCCATGAGGTGGTGACCCTGTGGTACCGAGCTCCTGAAATCCTCCTGGGCTGCA
AATATTATTCCACAGCTGTGGACATCTGGAGCCTGGGCTGCATCTTTGCTGAGATGATACCCTACAGACTCAAGGAGTCAGACAGTGAAT
TTGACAGCTTCAGCCAGGTCACTGAGTCACCAGTAGGACGAGAAGAGGAACCACATCTCCACATGGTTTCTAAGAAATACCGCAAGGTGA
CCATCAAATATTCCAAGCTAGGGCTGGAGGACTTTGACTTCAAACACTACAATAAGACCTTGTTTGCTGGATTAGAGCCCCACATTCCCA
ACGCCTACTGTAACTGCATGATCCAGGTGCTCTATTTCCTGGAGCCTGTACGCTGTCTAATTCAAAACCACCTTTGCCAGAAGGAGTTCT
GTCTGGCATGTGAGCTGGGCTTCCTGTTTCACATGTTGGACCTCTCTCGTGGTGACCCTTGCCAGGGCAATAATTTTCTTCGGGCATTCC
GTACTATTCCTGAGGCCTCAGCCCTCGGTCTAATCCTGGCTGACTCAGATGAGGCCTCAGGCAAGGGCAATCTGGCCAGGCTCATTCAGA
GGTGGAATCGCTTCATTCTCACTCAACTGCATCAAGATATGCAGGAGCTGGAAATACCACAGGCTTATCGAGGTGCTGGAGGCAGCAGCT
TTTGCTCATCGGGGGACTCTGTTATTGGGCAGCTCTTCAGCTGTGAGATGGAGAACTGCAGCCTCTGCCGCTGTGGCAGTGAGACCGTGC
GAGCCTCATCCACTCTGCTTTTCACACTCTCCTACCCTGATGATAAAACTGGGAAGAACTATGACTTTGCTCAGGTGCTGAAGCGAAGCA
TCTGCCTGGACCAGAATACACAGGCCTGGTGTGACACCTGTGAAAAGTACCAGCCCACGATTCAGACCCGCAACATCCGCCATCTGCCAG
ATATTCTTGTCATCAATTGTGAGGTGAACAGCTCAAAAGAGGCTGATTTCTGGAGAATGCAGGCTGAGGTTGCCTTCAAGATGGCAGTAA
AGAAACACGGTGGGGAAATCTCCAAGAACAAGGAATTTGCTTTGGCTGATTGGAAGGAACTAGGGAGTCCAGAGGGTGTGCTGGTGTGTC
CCTCCATTGAGGAGTTGAAGAACGTCTGGCTTCCTTTCTCCATTCGCATGAAGATGACCAAAAACAAAGGGCTGGATGTTTGCAATTGGA
CTGATGGGGATGAGATGCAGTGGGGCCCAGCCAGGGCAGAGGAGGAGCATGGTGTCTATGTGTATGACCTGATGGCTACTGTGGTACACA
TCCTGGACTCACGCACAGGGGGCAGCCTGGTGGCTCACATCAAAGTTGGAGAGACCTACCACCAGCGCAAGGAGGGCGTTACTCACCAGC
AGTGGTATCTGTTCAATGACTTTCTTATTGAACCTATTGATAAGCATGAAGCTGTGCAGTTTGACATGAATTGGAAAGTACCTGCAATCC
TTTATTATGTCAAACGGAATCTCAATTCCAGATACAACCTGAACATCAAGAACCCTATTGAGGCAAGTGTCTTGCTGGCTGAAGCCTCGC
TGGCACGGAAGCAGCGGAAAACACATACTACCTTTATTCCACTGATGCTGAATGAGATGCCACAGATTGGGGACCTGGTGGGTCTGGATG
CTGAGTTTGTCACCCTTAATGAGGAGGAAGCAGAGTTACGCAGTGATGGTACCAAGTCTACCATTAAACCAAGCCAGATGTCAGTAGCCA
GGATTACCTGTGTTCGGGGCCAGGGACCCAATGAGGGTATCCCCTTCATTGATGACTACATCTCTACCCAGGAGCAGGTGGTGGATTACT
TGACTCAATACTCGGGTATAAAGCCTGGTGACCTCGATGCCAAAATTTCCTCCAAGCACCTAACAACTCTCAAGTCTACCTACTTAAAGC
TTCGTTTTCTCATTGACATTGGAGTCAAGTTTGTGGGTCATGGCCTGCAGAAGGACTTCCGGGTCATCAACCTGATGGTGCCCAAGGACC
AAGTCCTTGACACTGTCTACCTGTTCCATATGCCCCGAAAACGAATGATTTCCCTGCGATTCCTTGCTTGGTACTTTCTGGACCTGAAGA
TTCAAGGGGAAACCCATGACAGTATTGAGGATGCCCGCACAGCCCTTCAGCTGTACCGAAAGTATCTGGAGCTAAGCAAAAATGGCACTG
AGCCTGAGTCTTTCCACAAGGTGCTCAAGGGTCTTTATGAGAAGGGCAGAAAGATGGACTGGAAGGTGCCTGAGCCTGAGGGCCAAACAA
GTCCCAAGAATGCAGCTGTCTTCTCCTCAGTGCTGGCGCTCTGACTACCCTTCCCAAAGAACCACGGCCCTCTCCCTTTACTGTTCTATA
GCCCCAGAACTGGGAGATGGCTTCCTAAGTTGGCTATACCTTGTCCACTTCCAGTACTGGACGTGCTCAGGGTCTAGGGTCACAGATGGT
GCTATTAATTGAACTGGAACACAGCAGAATTGTTGCAAAGGTTCTAGGAGCCAGATTCATTCCTTCTTCATTCTTTGCAAAACAGTGGTA
CAGACATGGAGTCTAGAATTGACCCAGATGGAAAGTAATTGGTATTCTTAATATCCTGGGTGACTAATATCCAGGCAGAGAAGCTCCTGG
AACCATAACTGTAAGTTCCTAGCTGGCTAGGGATTGAAGTCCTGGACAGTGACAGAGGATACCACAGTAGTTCAAGACTTAGCACAAGTC
ACCAACTGCTTCAGGGATACCTGGAGGGGCCAGCAAGTAGAGTGTTGGTGGCCCAAGCAAACCAGTGTTGCCAATACCATTGCCAAAAGG
GCCTTTGGATCCTGGACAAAGCTTGGCTGCCGGCTTCATTTATTCCTGCTGATGGCTGAGAAGCATCTGTCTTCCATCCCACTTGCCTGT

>15243_15243_7_CDK2-PAN2_CDK2_chr12_56363360_ENST00000553376_PAN2_chr12_56719238_ENST00000440411_length(amino acids)=997AA_BP=252
MAKLTRARGILRSIPTRGHGTGPCFPLLGPREPGSAFCRVPRPPLQGRADPTRWRFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKK
IRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL
HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMIPYRLKESDSEFDSFSQV
TESPVGREEEPHLHMVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELG
FLFHMLDLSRGDPCQGNNFLRAFRTIPEASALGLILADSDEASGKGNLARLIQRWNRFILTQLHQDMQELEIPQAYRGAGGSSFCSSGDS
VIGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPDDKTGKNYDFAQVLKRSICLDQNTQAWCDTCEKYQPTIQTRNIRHLPDILVINC
EVNSSKEADFWRMQAEVAFKMAVKKHGGEISKNKEFALADWKELGSPEGVLVCPSIEELKNVWLPFSIRMKMTKNKGLDVCNWTDGDEMQ
WGPARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKHEAVQFDMNWKVPAILYYVKRN
LNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRG
QGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVY
LFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPEGQTSPKNAAV

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>15243_15243_8_CDK2-PAN2_CDK2_chr12_56363360_ENST00000553376_PAN2_chr12_56719238_ENST00000548043_length(transcript)=3688nt_BP=776nt
GGCGGCAACATTGTTTCAAGTTGGCCAAATTGACAAGAGCGAGAGGTATACTGCGTTCCATCCCGACCCGGGGCCACGGTACTGGGCCCT
GTTTCCCCCTCCTCGGCCCCCGAGAGCCAGGGTCCGCCTTCTGCAGGGTTCCCAGGCCCCCGCTCCAGGGCCGGGCTGACCCGACTCGCT
GGCGCTTCATGGAGAACTTCCAAAAGGTGGAAAAGATCGGAGAGGGCACGTACGGAGTTGTGTACAAAGCCAGAAACAAGTTGACGGGAG
AGGTGGTGGCGCTTAAGAAAATCCGCCTGGACACTGAGACTGAGGGTGTGCCCAGTACTGCCATCCGAGAGATCTCTCTGCTTAAGGAGC
TTAACCATCCTAATATTGTCAAGCTGCTGGATGTCATTCACACAGAAAATAAACTCTACCTGGTTTTTGAATTTCTGCACCAAGATCTCA
AGAAATTCATGGATGCCTCTGCTCTCACTGGCATTCCTCTTCCCCTCATCAAGAGCTATCTGTTCCAGCTGCTCCAGGGCCTAGCTTTCT
GCCATTCTCATCGGGTCCTCCACCGAGACCTTAAACCTCAGAATCTGCTTATTAACACAGAGGGGGCCATCAAGCTAGCAGACTTTGGAC
TAGCCAGAGCTTTTGGAGTCCCTGTTCGTACTTACACCCATGAGGTGGTGACCCTGTGGTACCGAGCTCCTGAAATCCTCCTGGGCTGCA
AATATTATTCCACAGCTGTGGACATCTGGAGCCTGGGCTGCATCTTTGCTGAGATGATACCCTACAGACTCAAGGAGTCAGACAGTGAAT
TTGACAGCTTCAGCCAGGTCACTGAGTCACCAGTAGGACGAGAAGAGGAACCACATCTCCACATGGTTTCTAAGAAATACCGCAAGGTGA
CCATCAAATATTCCAAGCTAGGGCTGGAGGACTTTGACTTCAAACACTACAATAAGACCTTGTTTGCTGGATTAGAGCCCCACATTCCCA
ACGCCTACTGTAACTGCATGATCCAGGTGCTCTATTTCCTGGAGCCTGTACGCTGTCTAATTCAAAACCACCTTTGCCAGAAGGAGTTCT
GTCTGGCATGTGAGCTGGGCTTCCTGTTTCACATGTTGGACCTCTCTCGTGGTGACCCTTGCCAGGGCAATAATTTTCTTCGGGCATTCC
GTACTATTCCTGAGGCCTCAGCCCTCGGTCTAATCCTGGCTGACTCAGATGAGGCCTCAGGCAAGGGCAATCTGGCCAGGCTCATTCAGA
GGTGGAATCGCTTCATTCTCACTCAACTGCATCAAGATATGCAGGAGCTGGAAATACCACAGGCTTATCGAGGTGCTGGAGGCAGCAGCT
TTTGCTCATCGGGGGACTCTGTTATTGGGCAGCTCTTCAGCTGTGAGATGGAGAACTGCAGCCTCTGCCGCTGTGGCAGTGAGACCGTGC
GAGCCTCATCCACTCTGCTTTTCACACTCTCCTACCCTGATGGTAGCAAAAGTGATAAAACTGGGAAGAACTATGACTTTGCTCAGGTGC
TGAAGCGAAGCATCTGCCTGGACCAGAATACACAGGCCTGGTGTGACACCTGTGAAAAGTACCAGCCCACGATTCAGACCCGCAACATCC
GCCATCTGCCAGATATTCTTGTCATCAATTGTGAGGTGAACAGCTCAAAAGAGGCTGATTTCTGGAGAATGCAGGCTGAGGTTGCCTTCA
AGATGGCAGTAAAGAAACACGGTGGGGAAATCTCCAAGAACAAGGAATTTGCTTTGGCTGATTGGAAGGAACTAGGGAGTCCAGAGGGTG
TGCTGGTGTGTCCCTCCATTGAGGAGTTGAAGAACGTCTGGCTTCCTTTCTCCATTCGCATGAAGATGACCAAAAACAAAGGGCTGGATG
TTTGCAATTGGACTGATGGGGATGAGATGCAGTGGGGCCCAGCCAGGGCAGAGGAGGAGCATGGTGTCTATGTGTATGACCTGATGGCTA
CTGTGGTACACATCCTGGACTCACGCACAGGGGGCAGCCTGGTGGCTCACATCAAAGTTGGAGAGACCTACCACCAGCGCAAGGAGGGCG
TTACTCACCAGCAGTGGTATCTGTTCAATGACTTTCTTATTGAACCTATTGATAAGCATGAAGCTGTGCAGTTTGACATGAATTGGAAAG
TACCTGCAATCCTTTATTATGTCAAACGGAATCTCAATTCCAGATACAACCTGAACATCAAGAACCCTATTGAGGCAAGTGTCTTGCTGG
CTGAAGCCTCGCTGGCACGGAAGCAGCGGAAAACACATACTACCTTTATTCCACTGATGCTGAATGAGATGCCACAGATTGGGGACCTGG
TGGGTCTGGATGCTGAGTTTGTCACCCTTAATGAGGAGGAAGCAGAGTTACGCAGTGATGGTACCAAGTCTACCATTAAACCAAGCCAGA
TGTCAGTAGCCAGGATTACCTGTGTTCGGGGCCAGGGACCCAATGAGGGTATCCCCTTCATTGATGACTACATCTCTACCCAGGAGCAGG
TGGTGGATTACTTGACTCAATACTCGGGTATAAAGCCTGGTGACCTCGATGCCAAAATTTCCTCCAAGCACCTAACAACTCTCAAGTCTA
CCTACTTAAAGCTTCGTTTTCTCATTGACATTGGAGTCAAGTTTGTGGGTCATGGCCTGCAGAAGGACTTCCGGGTCATCAACCTGATGG
TGCCCAAGGACCAAGTCCTTGACACTGTCTACCTGTTCCATATGCCCCGAAAACGAATGATTTCCCTGCGATTCCTTGCTTGGTACTTTC
TGGACCTGAAGATTCAAGGGGAAACCCATGACAGTATTGAGGATGCCCGCACAGCCCTTCAGCTGTACCGAAAGTATCTGGAGCTAAGCA
AAAATGGCACTGAGCCTGAGTCTTTCCACAAGGTGCTCAAGGGTCTTTATGAGAAGGGCAGAAAGATGGACTGGAAGGTGCCTGAGCCTG
AGGGCCAAACAAGTCCCAAGAATGCAGCTGTCTTCTCCTCAGTGCTGGCGCTCTGACTACCCTTCCCAAAGAACCACGGCCCTCTCCCTT
TACTGTTCTATAGCCCCAGAACTGGGAGATGGCTTCCTAAGTTGGCTATACCTTGTCCACTTCCAGTACTGGACGTGCTCAGGGTCTAGG
GTCACAGATGGTGCTATTAATTGAACTGGAACACAGCAGAATTGTTGCAAAGGTTCTAGGAGCCAGATTCATTCCTTCTTCATTCTTTGC
AAAACAGTGGTACAGACATGGAGTCTAGAATTGACCCAGATGGAAAGTAATTGGTATTCTTAATATCCTGGGTGACTAATATCCAGGCAG
AGAAGCTCCTGGAACCATAACTGTAAGTTCCTAGCTGGCTAGGGATTGAAGTCCTGGACAGTGACAGAGGATACCACAGTAGTTCAAGAC
TTAGCACAAGTCACCAACTGCTTCAGGGATACCTGGAGGGGCCAGCAAGTAGAGTGTTGGTGGCCCAAGCAAACCAGTGTTGCCAATACC
ATTGCCAAAAGGGCCTTTGGATCCTGGACAAAGCTTGGCTGCCGGCTTCATTTATTCCTGCTGATGGCTGAGAAGCATCTGTCTTCCATC

>15243_15243_8_CDK2-PAN2_CDK2_chr12_56363360_ENST00000553376_PAN2_chr12_56719238_ENST00000548043_length(amino acids)=1001AA_BP=252
MAKLTRARGILRSIPTRGHGTGPCFPLLGPREPGSAFCRVPRPPLQGRADPTRWRFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKK
IRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL
HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMIPYRLKESDSEFDSFSQV
TESPVGREEEPHLHMVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELG
FLFHMLDLSRGDPCQGNNFLRAFRTIPEASALGLILADSDEASGKGNLARLIQRWNRFILTQLHQDMQELEIPQAYRGAGGSSFCSSGDS
VIGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPDGSKSDKTGKNYDFAQVLKRSICLDQNTQAWCDTCEKYQPTIQTRNIRHLPDIL
VINCEVNSSKEADFWRMQAEVAFKMAVKKHGGEISKNKEFALADWKELGSPEGVLVCPSIEELKNVWLPFSIRMKMTKNKGLDVCNWTDG
DEMQWGPARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKHEAVQFDMNWKVPAILYY
VKRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARIT
CVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVL
DTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPEGQTSPK

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Fusion Gene PPI Analysis for CDK2-PAN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDK2-PAN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDK2-PAN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource