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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDK5RAP1-CDH4 (FusionGDB2 ID:15260)

Fusion Gene Summary for CDK5RAP1-CDH4

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK5RAP1-CDH4
Fusion gene ID: 15260
HgeneTgene
Gene symbol

CDK5RAP1

CDH4

Gene ID

51654

1002

Gene nameCDK5 regulatory subunit associated protein 1cadherin 4
SynonymsC20orf34|C42|CGI-05|HSPC167CAD4|R-CAD|RCAD
Cytomap

20q11.21

20q13.33

Type of geneprotein-codingprotein-coding
DescriptionCDK5 regulatory subunit-associated protein 1CDK5 activator-binding protein C42cadherin-4R-cadherincadherin 4, type 1, R-cadherin (retinal)cadherin 4, type 1, preproproteinretinal cadherin
Modification date2020031320200313
UniProtAcc

Q96SZ6

P55283

Ensembl transtripts involved in fusion geneENST00000477105, ENST00000473997, 
ENST00000346416, ENST00000357886, 
ENST00000544843, ENST00000339269, 
ENST00000360469, ENST00000543233, 
Fusion gene scores* DoF score7 X 6 X 5=21016 X 14 X 7=1568
# samples 721
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1568*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDK5RAP1 [Title/Abstract] AND CDH4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDK5RAP1(31967267)-CDH4(60503248), # samples:1
Anticipated loss of major functional domain due to fusion event.CDK5RAP1-CDH4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CDK5RAP1-CDH4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CDK5RAP1-CDH4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK5RAP1

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

11882646


check buttonFusion gene breakpoints across CDK5RAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDH4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-75-6211-01ACDK5RAP1chr20

31967267

-CDH4chr20

60503248

+


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Fusion Gene ORF analysis for CDK5RAP1-CDH4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000477105ENST00000360469CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+
5UTR-3CDSENST00000477105ENST00000543233CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+
Frame-shiftENST00000473997ENST00000360469CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+
Frame-shiftENST00000473997ENST00000543233CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+
In-frameENST00000346416ENST00000360469CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+
In-frameENST00000346416ENST00000543233CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+
In-frameENST00000357886ENST00000360469CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+
In-frameENST00000357886ENST00000543233CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+
In-frameENST00000544843ENST00000360469CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+
In-frameENST00000544843ENST00000543233CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+
intron-3CDSENST00000339269ENST00000360469CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+
intron-3CDSENST00000339269ENST00000543233CDK5RAP1chr20

31967267

-CDH4chr20

60503248

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346416CDK5RAP1chr2031967267-ENST00000360469CDH4chr2060503248+591312611421374410
ENST00000346416CDK5RAP1chr2031967267-ENST00000543233CDH4chr2060503248+254712611421374410
ENST00000357886CDK5RAP1chr2031967267-ENST00000360469CDH4chr2060503248+595513031421416424
ENST00000357886CDK5RAP1chr2031967267-ENST00000543233CDH4chr2060503248+258913031421416424
ENST00000544843CDK5RAP1chr2031967267-ENST00000360469CDH4chr2060503248+587112191001332410
ENST00000544843CDK5RAP1chr2031967267-ENST00000543233CDH4chr2060503248+250512191001332410

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346416ENST00000360469CDK5RAP1chr2031967267-CDH4chr2060503248+0.0528756450.9471243
ENST00000346416ENST00000543233CDK5RAP1chr2031967267-CDH4chr2060503248+0.033640420.96635956
ENST00000357886ENST00000360469CDK5RAP1chr2031967267-CDH4chr2060503248+0.0591409020.94085914
ENST00000357886ENST00000543233CDK5RAP1chr2031967267-CDH4chr2060503248+0.045391930.9546081
ENST00000544843ENST00000360469CDK5RAP1chr2031967267-CDH4chr2060503248+0.0527404550.9472595
ENST00000544843ENST00000543233CDK5RAP1chr2031967267-CDH4chr2060503248+0.037573150.9624269

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Fusion Genomic Features for CDK5RAP1-CDH4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDK5RAP1chr2031967266-CDH4chr2060503247+6.64E-161
CDK5RAP1chr2031967266-CDH4chr2060503247+6.64E-161

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDK5RAP1-CDH4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:31967267/chr20:60503248)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK5RAP1

Q96SZ6

CDH4

P55283

FUNCTION: Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease (PubMed:25738458). {ECO:0000269|PubMed:11882646, ECO:0000269|PubMed:22422838, ECO:0000269|PubMed:25738458, ECO:0000269|PubMed:28981754}.FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000346416-814100_220369588.0DomainMTTase N-terminal
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000357886-915100_220383602.0DomainMTTase N-terminal
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000544843-812100_220369427.6666666666667DomainMTTase N-terminal
TgeneCDH4chr20:31967267chr20:60503248ENST000003604691016873_888590917.0Compositional biasNote=Ser-rich
TgeneCDH4chr20:31967267chr20:60503248ENST00000543233915873_888516843.0Compositional biasNote=Ser-rich
TgeneCDH4chr20:31967267chr20:60503248ENST000003604691016614_724590917.0DomainCadherin 5
TgeneCDH4chr20:31967267chr20:60503248ENST00000543233915614_724516843.0DomainCadherin 5
TgeneCDH4chr20:31967267chr20:60503248ENST000003604691016757_916590917.0Topological domainCytoplasmic
TgeneCDH4chr20:31967267chr20:60503248ENST00000543233915757_916516843.0Topological domainCytoplasmic
TgeneCDH4chr20:31967267chr20:60503248ENST000003604691016735_756590917.0TransmembraneHelical
TgeneCDH4chr20:31967267chr20:60503248ENST00000543233915735_756516843.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000339269-113100_2200511.0DomainMTTase N-terminal
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000339269-113244_5120511.0DomainRadical SAM core
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000339269-113515_5900511.0DomainTRAM
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000346416-814244_512369588.0DomainRadical SAM core
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000346416-814515_590369588.0DomainTRAM
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000357886-915244_512383602.0DomainRadical SAM core
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000357886-915515_590383602.0DomainTRAM
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000544843-812244_512369427.6666666666667DomainRadical SAM core
HgeneCDK5RAP1chr20:31967267chr20:60503248ENST00000544843-812515_590369427.6666666666667DomainTRAM
TgeneCDH4chr20:31967267chr20:60503248ENST000003604691016170_277590917.0DomainCadherin 1
TgeneCDH4chr20:31967267chr20:60503248ENST000003604691016278_392590917.0DomainCadherin 2
TgeneCDH4chr20:31967267chr20:60503248ENST000003604691016393_507590917.0DomainCadherin 3
TgeneCDH4chr20:31967267chr20:60503248ENST000003604691016508_613590917.0DomainCadherin 4
TgeneCDH4chr20:31967267chr20:60503248ENST00000543233915170_277516843.0DomainCadherin 1
TgeneCDH4chr20:31967267chr20:60503248ENST00000543233915278_392516843.0DomainCadherin 2
TgeneCDH4chr20:31967267chr20:60503248ENST00000543233915393_507516843.0DomainCadherin 3
TgeneCDH4chr20:31967267chr20:60503248ENST00000543233915508_613516843.0DomainCadherin 4
TgeneCDH4chr20:31967267chr20:60503248ENST000003604691016170_734590917.0Topological domainExtracellular
TgeneCDH4chr20:31967267chr20:60503248ENST00000543233915170_734516843.0Topological domainExtracellular


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Fusion Gene Sequence for CDK5RAP1-CDH4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15260_15260_1_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000346416_CDH4_chr20_60503248_ENST00000360469_length(transcript)=5913nt_BP=1261nt
AGCATGACCCGGCCTGAAGTAGCGGCGGAACGGAAGTCGCTTGTGTATGAACGCAGCGGCGGACCTGTGAGGGGATCCGACTTGCCGGCA
GAACTTACGCTGCGGGACCCCGGGCACTGTTGCTGCTGCGGGAGACTGTGGGCTGTTTAGTGCCATGCACCCTTTACAGTGTGTCCTCCA
AGTGCAGAGGTCTCTGGGGTGGGGACCATTGGCCTCTGTGTCTTGGCTGTCGCTGAGGATGTGCAGGGCACACAGCAGTCTCTCTAGTAC
CATGTGTCCCAGTCCAGAGAGGCAGGAGGATGGAGCTCGGAAGGATTTCAGCTCCAGGCTGGCTGCTGGACCGACTTTTCAACATTTTTT
AAAAAGTGCCTCAGCTCCTCAGGAGAAGCTGTCTTCAGAAGTGGAAGACCCACCTCCCTATCTCATGATGGATGAACTTCTTGGAAGGCA
GAGAAAAGTCTACCTCGAGACCTATGGCTGCCAGATGAATGTGAATGACACAGAGATAGCCTGGTCCATCTTACAGAAGAGTGGCTACCT
GCGGACCAGTAACCTCCAAGAGGCAGATGTGATTCTCCTTGTCACATGCTCTATCAGGGAGAAGGCTGAGCAGACCATCTGGAACCGTTT
ACATCAGCTTAAAGCCTTGAAGACAAGGCGGCCCCGCTCCCGGGTTCCTCTGAGGATTGGAATTCTAGGCTGCATGGCTGAGAGGTTGAA
GGAGGAGATTCTCAACAGAGAGAAAATGGTAGATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGA
GTCGGGCCAGCAAGCTGCCAACGTGCTGCTCTCTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTC
TGCCTTTGTGTCAATCATGCGAGGCTGTGACAACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTAT
TGCCTCCATTCTAGAGGAAGTGAAGAAGCTTTCTGAGCAGGGGCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGA
CAATTCGGAGGTCCAGTTCAACAGTGCAGTGCCTACCAATCTCAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCG
TTTTGCTCATCTTCTGGATCAGGTCTCCAGAGTAGATCCTGAAATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGA
GGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGACATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGAGGCG
CAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGACGCTGACGTCGACCCCAACATCGGCCCCTACGTCTTCGAG
CTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTGAACGGTGACTATGCCCAACTCAGCTTGCGCATCCTGTAC
CTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAACCCTCCCCTGTCCAACACGTCCATCATCAAAGTCAAGGTG
TGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCGGCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCTCATC
TGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAGCGGCGAGAGAAGGAGCGCCACACGAAGCAGCTGCTCATT
GACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGCGGTGGCGAGGAGGACCAGGACTACGACCTCAGCCAGCTG
CAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGTCGCGTGGATGAGCGGCCGGTGGGCGCTGAGCCCCAGTAC
CCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAATGAGGGACTCCGCGCTGCTGACAACGACCCCACGGCACCC
CCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCAGGCTCCGTCAGCTCCCTGAACTCATCCAGTTCCGGGGAC
CAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCGGACATGTATGGAGGTGGTGAAGAGGATTGACTGACCTCG
CATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGGAGCAGGACTGAGCAGAGGCGGCCGGTCTTCCCGACTCCCTGCGGCTGT
GTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAGCTGTCTAGCATGAGCACCCACCCCCACAGCGCCCTGCACCCGGCCGCT
GCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGCACTCTGTCTTCACTTGAATTTCCTAGAACAGAAGCACTGTTTTTAAAA
AAAAAAAAAAAAAAAGAAGAAAGAAAGAAAAAAAAAAAAAAAAGAAAGTGCCTTTTGGTATGTATCAGATTCCCTCAAACTCAGGAGTGT
CTAAAGCAGACAGACCGTCCCCACCTTCCCATCCCGAGCGGCCTCCAACCCCAGCTAGTCCCAGCTCTGAAGGCATCATTCAGAAATGGG
GGAGACTGTGTCTGTCTTTCTTACTTTTTTTTTGGTCTTTTATTAAGAAAAAGAAAGTGGGTGACTTGTTTGAAAACAGAGTGGGGTTCA
AATCCCAGCAGCCTTTGCTGTACACAGCTGGGGGTCTCTTGAGCCTCTTGGGAGTCAAGGCCAGCTGGGAGGCTTAGCCCTTCAGCCCCA
GCAGAAGGCCCTGGGGCTGGTGGGGCTCAGAATACCCCTACCTTGTGGCTGCTCCCCACCCCTCCCGGATGCTGTGAGGAGCTCAGGCAG
GGGCCTGGAGGGGAACAGGGGTCATCCTGAAGGGGCTCCACCCCCAGTCAACCCAGGCCTCCCTCAGGGACACCTGTCACCCTGAGTGCC
ACCAGGTCCCCTCTGCCTTTGGTCCAGAAGAGTGAGTTGTCCAAACCAGCCAGCATCTGGCTCCAGCCCTCCAACCCTGGCGACCAGACC
CCATGGGGTGCCATCAACGGCCCCGCGACAGGCATCAATTCAAACCCCAGGACACTCTCGACAGCTCCAACCATCCGGAGGGCTGTGCAG
ATGGCAGGAACCAAGGACCCTCCCTGGCAGCTGAAGAGGGCAGTTACGGTTGGGCGTGGTGACCAGAACACACCCAGCAGCCTGCGAAGC
CTCCCCGTCCCCAGCCTGTGCTCCTGATTCCCGCCAGACGCTTGTGAGCCTGTGTGGGTGGCAGGAGGCCCCGTCTTGCCGTGCCTACCT
GTCGCACAGATGCCTCTGCACGCTGCAGACGGTGCCTCTCCTCTCCTATGGACCCTCGTCGGGGGCAGGCAGCGGCCGGGTCCAAACTTG
CTGCTGTCCTCGAGGCTGGCACTGCTATCTCCAGGGCTGGGTTGACTCAAGCCAGACAGGGGGAAGGAATTGGTTCTGCAGGACAGTGAG
AGGGTCTGTGTCCCGGCACCCCTGGGACAGCGCTCGGCTGCCTGTGCTCACTGCATGAGAAAACTCAGAGGGTGCATTCTCCCTCTGGCA
TGGCTGTGTCTGGGCGCCTTGGGCTGCGGCAGGGGGCAGGCCCCACGTGGGGAAGCCTCGTGCTTGGTCAGCTTTCTGTCTCTCCCAGGC
CAGTGACAACTGGCTTCCCGAGGAAGGAGGTGAGGTACCAGGGACCCTGGGCAGGACCTGGTGTCGGGCAGGGCGGTGCCAGCACTGGGG
AAGGACAGGGAGCCCTCCCGGAGCCCCACCCTGCACCTGCCACTGGGGTCAGGGAGTGTCTCGGGGTGCCTTTGGGGGCAGCATGAGCTC
CACCAGGGGCCCCGGCCCCCACCTCAGCCTATGGCCCTTCCCCATGGCTAAGGTCATGCCTTTTCTGAACAGCTTTGGCCTTGAGTGCAC
ACATCTGTGCCAGGCTCACGGCATGTTCCCGTTGGATGTCAGGGTCCTTGTCCAAACCAAACTCACAGCTGCCCCTGTGCAGCCTTCAGA
GTTGAGCTGGGGTCTCAGTCTCCAACCTGTCCTTTCTGACCCTCCCATGGCTGCCCAGGGAGGGCGGGGTTCACTGTGCCACGTGCTGGG
TGCCCCCCTCTGCAGACAGCCAGTCCAGGAGATGGACCAACAGAGGTCAAGGGGCAGCTGGCCAGGCCGCACCGGGGTCCCCGAGTTCTG
AGCTGTGCTATGCAAACAAGAATGCTCCTGTGTGGGGGGGCATGGCCGTTGGAGGTATAGCTGGGCGGGTAGTGGAAGGACTGGAAATCT
CTGTTGTTGTTTGGGGAAGTCCATGCTTCAGTCCTTCGGAGTATGCGTGGATTGTTCGAAGTGTGACTATGGCCCGGGAGCCAGGGCAGC
ATGAACTCCTTTCTCTGAAATTTCGAGGCCTCCTTGGGTTCCCTGAACTCCGGGCTGATGTTCCCAGGACCCAGCACCAGGAGACCCCAG
TCCCGCCAGCAGCCGCCGCTACCCAGGAGGGCTGGGCGACATTGGCCGCCTCCCACTAGCTCCCCCTCCTCGCCCACAGCCTCTTGTCAC
TGCCAAGCCCCCGTTCCTTTTGCCCAAATCACGCAGGCGGAAGCTGCAGTGCCAGCTGGAGGGATGTTCATAGGGCTTCCTGTGCCCATC
CCTGCTCCAAACAGCTGGACAGCTTCCCCTCTACCCCCACCCTGGTGAGCCCCTGGGGGCCAGAGAAAGATGGGGTTCCTGCACCTTCCC
AGCTCCACCTCTGAACTTGAGTTAGCGTTAGCTAAGCATACAATCAGTGTCGAACGTCTCTCTTCCTTAAGCTTGTAGATACGACTGCCT
ATAATCAGGGGACTCCCACTGGAGGCCGGGAGGCCAATGCTGGCCAGGTGCGAGGGCATGGTTTGGTTCCTTTAGGGAATTTTTGTTTTG
CAAACAGGAGAAACCTGTGCTGCAGGTTGGAGTGGCAGGAACGACTGGCCTTGGTCAGCAGGCAGCCCCCAGCCTAGGGCCACAGTCCTC
TTCAGGGCCTGGGCAGCCCCAATTTCTGGCCCAGCAGGTTTCTCTTTGTAGTGTCTTTCAGCACATCCAAAATGCTAGGCCTCCTGCCAC
CAACGTGTCAGAGCAATGTCCAACTGTCAGGCTCTCAGAGATGCCTCAGTTTCCCTAGCATGAGCACCAGCCGACACACACAGTCCACTG
AGATGATAATTCTGTTCTCTCCAAAGCAAAAAGCTGGGCGAGGGGTAGTCTCAATTTCTGTCAGTGCTCAAAGGAATAACACCAAAAGAA
TCAACACAGAATCTCCCAGACACACGTGACCCAGCTCGTGGCGCCGTGGGTCCGTAGGAGGGACAGTACCTCACAACAGGCCCAGCGGGG
GACCACCTCTCTGTACAATTGGAATGCGTTTTACTTTTCTTTTCTCTCCTTTTTTCATTCCGATTTTTTTTGCATGTTTCTTTTTGAAAT
GGGCAAAATGTGTAGCAGCCTGCATGAGCACAGTTGTTTTGGGGAAAGATACTGGAGTATGATGTACTCACACCTGCAAATCTGAGCATC
GCGAGGTTAAACGTTCCACCTTTTTTTGTAATCGTCAACAGCACAACTATTTTGTATTGTTGTTTGTATCATTTTGTACCAAAAAAAAAA
AGGAAAAAAAAAGGGAAGAGAGTTGATGTTTTCAGTGTGTTTCCAGTGCCAGACAGTCTTGGTCCTGAACTCAGTAGACCCTTGCGGAGC

>15260_15260_1_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000346416_CDH4_chr20_60503248_ENST00000360469_length(amino acids)=410AA_BP=373
MFSAMHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDP
PPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPL
RIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCI
VPFTRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRI

--------------------------------------------------------------
>15260_15260_2_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000346416_CDH4_chr20_60503248_ENST00000543233_length(transcript)=2547nt_BP=1261nt
AGCATGACCCGGCCTGAAGTAGCGGCGGAACGGAAGTCGCTTGTGTATGAACGCAGCGGCGGACCTGTGAGGGGATCCGACTTGCCGGCA
GAACTTACGCTGCGGGACCCCGGGCACTGTTGCTGCTGCGGGAGACTGTGGGCTGTTTAGTGCCATGCACCCTTTACAGTGTGTCCTCCA
AGTGCAGAGGTCTCTGGGGTGGGGACCATTGGCCTCTGTGTCTTGGCTGTCGCTGAGGATGTGCAGGGCACACAGCAGTCTCTCTAGTAC
CATGTGTCCCAGTCCAGAGAGGCAGGAGGATGGAGCTCGGAAGGATTTCAGCTCCAGGCTGGCTGCTGGACCGACTTTTCAACATTTTTT
AAAAAGTGCCTCAGCTCCTCAGGAGAAGCTGTCTTCAGAAGTGGAAGACCCACCTCCCTATCTCATGATGGATGAACTTCTTGGAAGGCA
GAGAAAAGTCTACCTCGAGACCTATGGCTGCCAGATGAATGTGAATGACACAGAGATAGCCTGGTCCATCTTACAGAAGAGTGGCTACCT
GCGGACCAGTAACCTCCAAGAGGCAGATGTGATTCTCCTTGTCACATGCTCTATCAGGGAGAAGGCTGAGCAGACCATCTGGAACCGTTT
ACATCAGCTTAAAGCCTTGAAGACAAGGCGGCCCCGCTCCCGGGTTCCTCTGAGGATTGGAATTCTAGGCTGCATGGCTGAGAGGTTGAA
GGAGGAGATTCTCAACAGAGAGAAAATGGTAGATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGA
GTCGGGCCAGCAAGCTGCCAACGTGCTGCTCTCTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTC
TGCCTTTGTGTCAATCATGCGAGGCTGTGACAACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTAT
TGCCTCCATTCTAGAGGAAGTGAAGAAGCTTTCTGAGCAGGGGCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGA
CAATTCGGAGGTCCAGTTCAACAGTGCAGTGCCTACCAATCTCAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCG
TTTTGCTCATCTTCTGGATCAGGTCTCCAGAGTAGATCCTGAAATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGA
GGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGACATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGAGGCG
CAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGACGCTGACGTCGACCCCAACATCGGCCCCTACGTCTTCGAG
CTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTGAACGGTGACTATGCCCAACTCAGCTTGCGCATCCTGTAC
CTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAACCCTCCCCTGTCCAACACGTCCATCATCAAAGTCAAGGTG
TGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCGGCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCTCATC
TGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAGCGGCGAGAGAAGGAGCGCCACACGAAGCAGCTGCTCATT
GACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGCGGTGGCGAGGAGGACCAGGACTACGACCTCAGCCAGCTG
CAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGTCGCGTGGATGAGCGGCCGGTGGGCGCTGAGCCCCAGTAC
CCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAATGAGGGACTCCGCGCTGCTGACAACGACCCCACGGCACCC
CCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCAGGCTCCGTCAGCTCCCTGAACTCATCCAGTTCCGGGGAC
CAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCGGACATGTATGGAGGTGGTGAAGAGGATTGACTGACCTCG
CATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGGAGCAGGACTGAGCAGAGGCGGCCGGTCTTCCCGACTCCCTGCGGCTGT
GTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAGCTGTCTAGCATGAGCACCCACCCCCACAGCGCCCTGCACCCGGCCGCT
GCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGCACTCTGTCTTCACTTGAATTTCCTAGAACAGAAGCACTGTTTTTAAAA

>15260_15260_2_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000346416_CDH4_chr20_60503248_ENST00000543233_length(amino acids)=410AA_BP=373
MFSAMHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDP
PPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPL
RIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCI
VPFTRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRI

--------------------------------------------------------------
>15260_15260_3_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000357886_CDH4_chr20_60503248_ENST00000360469_length(transcript)=5955nt_BP=1303nt
AGCATGACCCGGCCTGAAGTAGCGGCGGAACGGAAGTCGCTTGTGTATGAACGCAGCGGCGGACCTGTGAGGGGATCCGACTTGCCGGCA
GAACTTACGCTGCGGGACCCCGGGCACTGTTGCTGCTGCGGGAGACTGTGGGCTGTTTAGTGCCATGCACCCTTTACAGTGTGTCCTCCA
AGTGCAGAGGTCTCTGGGGTGGGGACCATTGGCCTCTGTGTCTTGGCTGTCGCTGAGGATGTGCAGGGCACACAGCAGTCTCTCTAGTAC
CATGTGTCCCAGTCCAGAGAGGCAGGAGGATGGAGCTCGGAAGGATTTCAGCTCCAGGCTGGCTGCTGGACCGACTTTTCAACATTTTTT
AAAAAGTGCCTCAGCTCCTCAGGAGAAGCTGTCTTCAGAAGTGGAAGACCCACCTCCCTATCTCATGATGGATGAACTTCTTGGAAGGCA
GAGAAAAGTCTACCTCGAGACCTATGGCTGCCAGATGAATGTGAATGACACAGAGATAGCCTGGTCCATCTTACAGAAGAGTGGCTACCT
GCGGACCAGTAACCTCCAAGAGGCAGATGTGATTCTCCTTGTCACATGCTCTATCAGGGAGAAGGCTGAGCAGACCATCTGGAACCGTTT
ACATCAGCTTAAAGCCTTGAAGACAAGGCGGCCCCGCTCCCGGGTTCCTCTGAGGATTGGAATTCTAGGCTGCATGGCTGAGAGGTTGAA
GGAGGAGATTCTCAACAGAGAGAAAATGGTAGATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGA
GTCGGGCCAGCAAGCTGCCAACGTGCTGCTCTCTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTC
TGCCTTTGTGTCAATCATGCGAGGCTGTGACAACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTAT
TGCCTCCATTCTAGAGGAAGTGAAGAAGCTTTCTGAGCAGGTGTTCCTCCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGGGCTGAA
AGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGCCTACCAATCTCAGTCG
TGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAGTAGATCCTGAAATGAG
GATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGAGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATT
GACATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGAGGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCC
GACGCTGACGTCGACCCCAACATCGGCCCCTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGC
CTGAACGGTGACTATGCCCAACTCAGCTTGCGCATCCTGTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGA
AACCCTCCCCTGTCCAACACGTCCATCATCAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCA
GCGGCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCTCATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATG
AAGCGGCGAGAGAAGGAGCGCCACACGAAGCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAA
GGCGGTGGCGAGGAGGACCAGGACTACGACCTCAGCCAGCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTG
CGTCGCGTGGATGAGCGGCCGGTGGGCGCTGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATC
AATGAGGGACTCCGCGCTGCTGACAACGACCCCACGGCACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACC
GCAGGCTCCGTCAGCTCCCTGAACTCATCCAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTG
GCGGACATGTATGGAGGTGGTGAAGAGGATTGACTGACCTCGCATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGGAGCAGG
ACTGAGCAGAGGCGGCCGGTCTTCCCGACTCCCTGCGGCTGTGTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAGCTGTCT
AGCATGAGCACCCACCCCCACAGCGCCCTGCACCCGGCCGCTGCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGCACTCTG
TCTTCACTTGAATTTCCTAGAACAGAAGCACTGTTTTTAAAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAAAAAAAAAAAAAAGAAAG
TGCCTTTTGGTATGTATCAGATTCCCTCAAACTCAGGAGTGTCTAAAGCAGACAGACCGTCCCCACCTTCCCATCCCGAGCGGCCTCCAA
CCCCAGCTAGTCCCAGCTCTGAAGGCATCATTCAGAAATGGGGGAGACTGTGTCTGTCTTTCTTACTTTTTTTTTGGTCTTTTATTAAGA
AAAAGAAAGTGGGTGACTTGTTTGAAAACAGAGTGGGGTTCAAATCCCAGCAGCCTTTGCTGTACACAGCTGGGGGTCTCTTGAGCCTCT
TGGGAGTCAAGGCCAGCTGGGAGGCTTAGCCCTTCAGCCCCAGCAGAAGGCCCTGGGGCTGGTGGGGCTCAGAATACCCCTACCTTGTGG
CTGCTCCCCACCCCTCCCGGATGCTGTGAGGAGCTCAGGCAGGGGCCTGGAGGGGAACAGGGGTCATCCTGAAGGGGCTCCACCCCCAGT
CAACCCAGGCCTCCCTCAGGGACACCTGTCACCCTGAGTGCCACCAGGTCCCCTCTGCCTTTGGTCCAGAAGAGTGAGTTGTCCAAACCA
GCCAGCATCTGGCTCCAGCCCTCCAACCCTGGCGACCAGACCCCATGGGGTGCCATCAACGGCCCCGCGACAGGCATCAATTCAAACCCC
AGGACACTCTCGACAGCTCCAACCATCCGGAGGGCTGTGCAGATGGCAGGAACCAAGGACCCTCCCTGGCAGCTGAAGAGGGCAGTTACG
GTTGGGCGTGGTGACCAGAACACACCCAGCAGCCTGCGAAGCCTCCCCGTCCCCAGCCTGTGCTCCTGATTCCCGCCAGACGCTTGTGAG
CCTGTGTGGGTGGCAGGAGGCCCCGTCTTGCCGTGCCTACCTGTCGCACAGATGCCTCTGCACGCTGCAGACGGTGCCTCTCCTCTCCTA
TGGACCCTCGTCGGGGGCAGGCAGCGGCCGGGTCCAAACTTGCTGCTGTCCTCGAGGCTGGCACTGCTATCTCCAGGGCTGGGTTGACTC
AAGCCAGACAGGGGGAAGGAATTGGTTCTGCAGGACAGTGAGAGGGTCTGTGTCCCGGCACCCCTGGGACAGCGCTCGGCTGCCTGTGCT
CACTGCATGAGAAAACTCAGAGGGTGCATTCTCCCTCTGGCATGGCTGTGTCTGGGCGCCTTGGGCTGCGGCAGGGGGCAGGCCCCACGT
GGGGAAGCCTCGTGCTTGGTCAGCTTTCTGTCTCTCCCAGGCCAGTGACAACTGGCTTCCCGAGGAAGGAGGTGAGGTACCAGGGACCCT
GGGCAGGACCTGGTGTCGGGCAGGGCGGTGCCAGCACTGGGGAAGGACAGGGAGCCCTCCCGGAGCCCCACCCTGCACCTGCCACTGGGG
TCAGGGAGTGTCTCGGGGTGCCTTTGGGGGCAGCATGAGCTCCACCAGGGGCCCCGGCCCCCACCTCAGCCTATGGCCCTTCCCCATGGC
TAAGGTCATGCCTTTTCTGAACAGCTTTGGCCTTGAGTGCACACATCTGTGCCAGGCTCACGGCATGTTCCCGTTGGATGTCAGGGTCCT
TGTCCAAACCAAACTCACAGCTGCCCCTGTGCAGCCTTCAGAGTTGAGCTGGGGTCTCAGTCTCCAACCTGTCCTTTCTGACCCTCCCAT
GGCTGCCCAGGGAGGGCGGGGTTCACTGTGCCACGTGCTGGGTGCCCCCCTCTGCAGACAGCCAGTCCAGGAGATGGACCAACAGAGGTC
AAGGGGCAGCTGGCCAGGCCGCACCGGGGTCCCCGAGTTCTGAGCTGTGCTATGCAAACAAGAATGCTCCTGTGTGGGGGGGCATGGCCG
TTGGAGGTATAGCTGGGCGGGTAGTGGAAGGACTGGAAATCTCTGTTGTTGTTTGGGGAAGTCCATGCTTCAGTCCTTCGGAGTATGCGT
GGATTGTTCGAAGTGTGACTATGGCCCGGGAGCCAGGGCAGCATGAACTCCTTTCTCTGAAATTTCGAGGCCTCCTTGGGTTCCCTGAAC
TCCGGGCTGATGTTCCCAGGACCCAGCACCAGGAGACCCCAGTCCCGCCAGCAGCCGCCGCTACCCAGGAGGGCTGGGCGACATTGGCCG
CCTCCCACTAGCTCCCCCTCCTCGCCCACAGCCTCTTGTCACTGCCAAGCCCCCGTTCCTTTTGCCCAAATCACGCAGGCGGAAGCTGCA
GTGCCAGCTGGAGGGATGTTCATAGGGCTTCCTGTGCCCATCCCTGCTCCAAACAGCTGGACAGCTTCCCCTCTACCCCCACCCTGGTGA
GCCCCTGGGGGCCAGAGAAAGATGGGGTTCCTGCACCTTCCCAGCTCCACCTCTGAACTTGAGTTAGCGTTAGCTAAGCATACAATCAGT
GTCGAACGTCTCTCTTCCTTAAGCTTGTAGATACGACTGCCTATAATCAGGGGACTCCCACTGGAGGCCGGGAGGCCAATGCTGGCCAGG
TGCGAGGGCATGGTTTGGTTCCTTTAGGGAATTTTTGTTTTGCAAACAGGAGAAACCTGTGCTGCAGGTTGGAGTGGCAGGAACGACTGG
CCTTGGTCAGCAGGCAGCCCCCAGCCTAGGGCCACAGTCCTCTTCAGGGCCTGGGCAGCCCCAATTTCTGGCCCAGCAGGTTTCTCTTTG
TAGTGTCTTTCAGCACATCCAAAATGCTAGGCCTCCTGCCACCAACGTGTCAGAGCAATGTCCAACTGTCAGGCTCTCAGAGATGCCTCA
GTTTCCCTAGCATGAGCACCAGCCGACACACACAGTCCACTGAGATGATAATTCTGTTCTCTCCAAAGCAAAAAGCTGGGCGAGGGGTAG
TCTCAATTTCTGTCAGTGCTCAAAGGAATAACACCAAAAGAATCAACACAGAATCTCCCAGACACACGTGACCCAGCTCGTGGCGCCGTG
GGTCCGTAGGAGGGACAGTACCTCACAACAGGCCCAGCGGGGGACCACCTCTCTGTACAATTGGAATGCGTTTTACTTTTCTTTTCTCTC
CTTTTTTCATTCCGATTTTTTTTGCATGTTTCTTTTTGAAATGGGCAAAATGTGTAGCAGCCTGCATGAGCACAGTTGTTTTGGGGAAAG
ATACTGGAGTATGATGTACTCACACCTGCAAATCTGAGCATCGCGAGGTTAAACGTTCCACCTTTTTTTGTAATCGTCAACAGCACAACT
ATTTTGTATTGTTGTTTGTATCATTTTGTACCAAAAAAAAAAAGGAAAAAAAAAGGGAAGAGAGTTGATGTTTTCAGTGTGTTTCCAGTG
CCAGACAGTCTTGGTCCTGAACTCAGTAGACCCTTGCGGAGCGGTTGTGCGCGGGCAGGCGGGGCGCGCTGCTCCAGAGAATGAATAAAG

>15260_15260_3_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000357886_CDH4_chr20_60503248_ENST00000360469_length(amino acids)=424AA_BP=387
MFSAMHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDP
PPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPL
RIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCI
VPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKVLGLQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAH

--------------------------------------------------------------
>15260_15260_4_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000357886_CDH4_chr20_60503248_ENST00000543233_length(transcript)=2589nt_BP=1303nt
AGCATGACCCGGCCTGAAGTAGCGGCGGAACGGAAGTCGCTTGTGTATGAACGCAGCGGCGGACCTGTGAGGGGATCCGACTTGCCGGCA
GAACTTACGCTGCGGGACCCCGGGCACTGTTGCTGCTGCGGGAGACTGTGGGCTGTTTAGTGCCATGCACCCTTTACAGTGTGTCCTCCA
AGTGCAGAGGTCTCTGGGGTGGGGACCATTGGCCTCTGTGTCTTGGCTGTCGCTGAGGATGTGCAGGGCACACAGCAGTCTCTCTAGTAC
CATGTGTCCCAGTCCAGAGAGGCAGGAGGATGGAGCTCGGAAGGATTTCAGCTCCAGGCTGGCTGCTGGACCGACTTTTCAACATTTTTT
AAAAAGTGCCTCAGCTCCTCAGGAGAAGCTGTCTTCAGAAGTGGAAGACCCACCTCCCTATCTCATGATGGATGAACTTCTTGGAAGGCA
GAGAAAAGTCTACCTCGAGACCTATGGCTGCCAGATGAATGTGAATGACACAGAGATAGCCTGGTCCATCTTACAGAAGAGTGGCTACCT
GCGGACCAGTAACCTCCAAGAGGCAGATGTGATTCTCCTTGTCACATGCTCTATCAGGGAGAAGGCTGAGCAGACCATCTGGAACCGTTT
ACATCAGCTTAAAGCCTTGAAGACAAGGCGGCCCCGCTCCCGGGTTCCTCTGAGGATTGGAATTCTAGGCTGCATGGCTGAGAGGTTGAA
GGAGGAGATTCTCAACAGAGAGAAAATGGTAGATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGA
GTCGGGCCAGCAAGCTGCCAACGTGCTGCTCTCTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTC
TGCCTTTGTGTCAATCATGCGAGGCTGTGACAACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTAT
TGCCTCCATTCTAGAGGAAGTGAAGAAGCTTTCTGAGCAGGTGTTCCTCCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGGGCTGAA
AGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGCCTACCAATCTCAGTCG
TGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAGTAGATCCTGAAATGAG
GATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGAGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATT
GACATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGAGGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCC
GACGCTGACGTCGACCCCAACATCGGCCCCTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGC
CTGAACGGTGACTATGCCCAACTCAGCTTGCGCATCCTGTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGA
AACCCTCCCCTGTCCAACACGTCCATCATCAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCA
GCGGCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCTCATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATG
AAGCGGCGAGAGAAGGAGCGCCACACGAAGCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAA
GGCGGTGGCGAGGAGGACCAGGACTACGACCTCAGCCAGCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTG
CGTCGCGTGGATGAGCGGCCGGTGGGCGCTGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATC
AATGAGGGACTCCGCGCTGCTGACAACGACCCCACGGCACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACC
GCAGGCTCCGTCAGCTCCCTGAACTCATCCAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTG
GCGGACATGTATGGAGGTGGTGAAGAGGATTGACTGACCTCGCATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGGAGCAGG
ACTGAGCAGAGGCGGCCGGTCTTCCCGACTCCCTGCGGCTGTGTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAGCTGTCT
AGCATGAGCACCCACCCCCACAGCGCCCTGCACCCGGCCGCTGCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGCACTCTG

>15260_15260_4_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000357886_CDH4_chr20_60503248_ENST00000543233_length(amino acids)=424AA_BP=387
MFSAMHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDP
PPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPL
RIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCI
VPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKVLGLQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAH

--------------------------------------------------------------
>15260_15260_5_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000544843_CDH4_chr20_60503248_ENST00000360469_length(transcript)=5871nt_BP=1219nt
GTGTATGAACGCAGCGGCGGACCTGTGAGGGGATCCGACTTGCCGGCAGAACTTACGCTGCGGGACCCCGGGCACTGTTGCTGCTGCGGG
AGACTGTGGGCTGTTTAGTGCCATGCACCCTTTACAGTGTGTCCTCCAAGTGCAGAGGTCTCTGGGGTGGGGACCATTGGCCTCTGTGTC
TTGGCTGTCGCTGAGGATGTGCAGGGCACACAGCAGTCTCTCTAGTACCATGTGTCCCAGTCCAGAGAGGCAGGAGGATGGAGCTCGGAA
GGATTTCAGCTCCAGGCTGGCTGCTGGACCGACTTTTCAACATTTTTTAAAAAGTGCCTCAGCTCCTCAGGAGAAGCTGTCTTCAGAAGT
GGAAGACCCACCTCCCTATCTCATGATGGATGAACTTCTTGGAAGGCAGAGAAAAGTCTACCTCGAGACCTATGGCTGCCAGATGAATGT
GAATGACACAGAGATAGCCTGGTCCATCTTACAGAAGAGTGGCTACCTGCGGACCAGTAACCTCCAAGAGGCAGATGTGATTCTCCTTGT
CACATGCTCTATCAGGGAGAAGGCTGAGCAGACCATCTGGAACCGTTTACATCAGCTTAAAGCCTTGAAGACAAGGCGGCCCCGCTCCCG
GGTTCCTCTGAGGATTGGAATTCTAGGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAGATATTTTGGC
TGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCTCTCTGGACGA
GACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACAACATGTGTAG
CTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTTCTGAGCAGGG
GCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGCCTACCAATCT
CAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAGTAGATCCTGA
AATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGAGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTAT
CTCATTGACATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGAGGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACG
GCGGCCGACGCTGACGTCGACCCCAACATCGGCCCCTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATC
ACCCGCCTGAACGGTGACTATGCCCAACTCAGCTTGCGCATCCTGTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGAC
TCTGGAAACCCTCCCCTGTCCAACACGTCCATCATCAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCA
GTGGCAGCGGCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCTCATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATG
TGGATGAAGCGGCGAGAGAAGGAGCGCCACACGAAGCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGAC
GAGGAAGGCGGTGGCGAGGAGGACCAGGACTACGACCTCAGCCAGCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCT
GGCGTGCGTCGCGTGGATGAGCGGCCGGTGGGCGCTGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGAC
TTCATCAATGAGGGACTCCGCGCTGCTGACAACGACCCCACGGCACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGC
TCCACCGCAGGCTCCGTCAGCTCCCTGAACTCATCCAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAG
AAGCTGGCGGACATGTATGGAGGTGGTGAAGAGGATTGACTGACCTCGCATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGG
AGCAGGACTGAGCAGAGGCGGCCGGTCTTCCCGACTCCCTGCGGCTGTGTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAG
CTGTCTAGCATGAGCACCCACCCCCACAGCGCCCTGCACCCGGCCGCTGCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGC
ACTCTGTCTTCACTTGAATTTCCTAGAACAGAAGCACTGTTTTTAAAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAAAAAAAAAAAAA
AGAAAGTGCCTTTTGGTATGTATCAGATTCCCTCAAACTCAGGAGTGTCTAAAGCAGACAGACCGTCCCCACCTTCCCATCCCGAGCGGC
CTCCAACCCCAGCTAGTCCCAGCTCTGAAGGCATCATTCAGAAATGGGGGAGACTGTGTCTGTCTTTCTTACTTTTTTTTTGGTCTTTTA
TTAAGAAAAAGAAAGTGGGTGACTTGTTTGAAAACAGAGTGGGGTTCAAATCCCAGCAGCCTTTGCTGTACACAGCTGGGGGTCTCTTGA
GCCTCTTGGGAGTCAAGGCCAGCTGGGAGGCTTAGCCCTTCAGCCCCAGCAGAAGGCCCTGGGGCTGGTGGGGCTCAGAATACCCCTACC
TTGTGGCTGCTCCCCACCCCTCCCGGATGCTGTGAGGAGCTCAGGCAGGGGCCTGGAGGGGAACAGGGGTCATCCTGAAGGGGCTCCACC
CCCAGTCAACCCAGGCCTCCCTCAGGGACACCTGTCACCCTGAGTGCCACCAGGTCCCCTCTGCCTTTGGTCCAGAAGAGTGAGTTGTCC
AAACCAGCCAGCATCTGGCTCCAGCCCTCCAACCCTGGCGACCAGACCCCATGGGGTGCCATCAACGGCCCCGCGACAGGCATCAATTCA
AACCCCAGGACACTCTCGACAGCTCCAACCATCCGGAGGGCTGTGCAGATGGCAGGAACCAAGGACCCTCCCTGGCAGCTGAAGAGGGCA
GTTACGGTTGGGCGTGGTGACCAGAACACACCCAGCAGCCTGCGAAGCCTCCCCGTCCCCAGCCTGTGCTCCTGATTCCCGCCAGACGCT
TGTGAGCCTGTGTGGGTGGCAGGAGGCCCCGTCTTGCCGTGCCTACCTGTCGCACAGATGCCTCTGCACGCTGCAGACGGTGCCTCTCCT
CTCCTATGGACCCTCGTCGGGGGCAGGCAGCGGCCGGGTCCAAACTTGCTGCTGTCCTCGAGGCTGGCACTGCTATCTCCAGGGCTGGGT
TGACTCAAGCCAGACAGGGGGAAGGAATTGGTTCTGCAGGACAGTGAGAGGGTCTGTGTCCCGGCACCCCTGGGACAGCGCTCGGCTGCC
TGTGCTCACTGCATGAGAAAACTCAGAGGGTGCATTCTCCCTCTGGCATGGCTGTGTCTGGGCGCCTTGGGCTGCGGCAGGGGGCAGGCC
CCACGTGGGGAAGCCTCGTGCTTGGTCAGCTTTCTGTCTCTCCCAGGCCAGTGACAACTGGCTTCCCGAGGAAGGAGGTGAGGTACCAGG
GACCCTGGGCAGGACCTGGTGTCGGGCAGGGCGGTGCCAGCACTGGGGAAGGACAGGGAGCCCTCCCGGAGCCCCACCCTGCACCTGCCA
CTGGGGTCAGGGAGTGTCTCGGGGTGCCTTTGGGGGCAGCATGAGCTCCACCAGGGGCCCCGGCCCCCACCTCAGCCTATGGCCCTTCCC
CATGGCTAAGGTCATGCCTTTTCTGAACAGCTTTGGCCTTGAGTGCACACATCTGTGCCAGGCTCACGGCATGTTCCCGTTGGATGTCAG
GGTCCTTGTCCAAACCAAACTCACAGCTGCCCCTGTGCAGCCTTCAGAGTTGAGCTGGGGTCTCAGTCTCCAACCTGTCCTTTCTGACCC
TCCCATGGCTGCCCAGGGAGGGCGGGGTTCACTGTGCCACGTGCTGGGTGCCCCCCTCTGCAGACAGCCAGTCCAGGAGATGGACCAACA
GAGGTCAAGGGGCAGCTGGCCAGGCCGCACCGGGGTCCCCGAGTTCTGAGCTGTGCTATGCAAACAAGAATGCTCCTGTGTGGGGGGGCA
TGGCCGTTGGAGGTATAGCTGGGCGGGTAGTGGAAGGACTGGAAATCTCTGTTGTTGTTTGGGGAAGTCCATGCTTCAGTCCTTCGGAGT
ATGCGTGGATTGTTCGAAGTGTGACTATGGCCCGGGAGCCAGGGCAGCATGAACTCCTTTCTCTGAAATTTCGAGGCCTCCTTGGGTTCC
CTGAACTCCGGGCTGATGTTCCCAGGACCCAGCACCAGGAGACCCCAGTCCCGCCAGCAGCCGCCGCTACCCAGGAGGGCTGGGCGACAT
TGGCCGCCTCCCACTAGCTCCCCCTCCTCGCCCACAGCCTCTTGTCACTGCCAAGCCCCCGTTCCTTTTGCCCAAATCACGCAGGCGGAA
GCTGCAGTGCCAGCTGGAGGGATGTTCATAGGGCTTCCTGTGCCCATCCCTGCTCCAAACAGCTGGACAGCTTCCCCTCTACCCCCACCC
TGGTGAGCCCCTGGGGGCCAGAGAAAGATGGGGTTCCTGCACCTTCCCAGCTCCACCTCTGAACTTGAGTTAGCGTTAGCTAAGCATACA
ATCAGTGTCGAACGTCTCTCTTCCTTAAGCTTGTAGATACGACTGCCTATAATCAGGGGACTCCCACTGGAGGCCGGGAGGCCAATGCTG
GCCAGGTGCGAGGGCATGGTTTGGTTCCTTTAGGGAATTTTTGTTTTGCAAACAGGAGAAACCTGTGCTGCAGGTTGGAGTGGCAGGAAC
GACTGGCCTTGGTCAGCAGGCAGCCCCCAGCCTAGGGCCACAGTCCTCTTCAGGGCCTGGGCAGCCCCAATTTCTGGCCCAGCAGGTTTC
TCTTTGTAGTGTCTTTCAGCACATCCAAAATGCTAGGCCTCCTGCCACCAACGTGTCAGAGCAATGTCCAACTGTCAGGCTCTCAGAGAT
GCCTCAGTTTCCCTAGCATGAGCACCAGCCGACACACACAGTCCACTGAGATGATAATTCTGTTCTCTCCAAAGCAAAAAGCTGGGCGAG
GGGTAGTCTCAATTTCTGTCAGTGCTCAAAGGAATAACACCAAAAGAATCAACACAGAATCTCCCAGACACACGTGACCCAGCTCGTGGC
GCCGTGGGTCCGTAGGAGGGACAGTACCTCACAACAGGCCCAGCGGGGGACCACCTCTCTGTACAATTGGAATGCGTTTTACTTTTCTTT
TCTCTCCTTTTTTCATTCCGATTTTTTTTGCATGTTTCTTTTTGAAATGGGCAAAATGTGTAGCAGCCTGCATGAGCACAGTTGTTTTGG
GGAAAGATACTGGAGTATGATGTACTCACACCTGCAAATCTGAGCATCGCGAGGTTAAACGTTCCACCTTTTTTTGTAATCGTCAACAGC
ACAACTATTTTGTATTGTTGTTTGTATCATTTTGTACCAAAAAAAAAAAGGAAAAAAAAAGGGAAGAGAGTTGATGTTTTCAGTGTGTTT
CCAGTGCCAGACAGTCTTGGTCCTGAACTCAGTAGACCCTTGCGGAGCGGTTGTGCGCGGGCAGGCGGGGCGCGCTGCTCCAGAGAATGA

>15260_15260_5_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000544843_CDH4_chr20_60503248_ENST00000360469_length(amino acids)=410AA_BP=373
MFSAMHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDP
PPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPL
RIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCI
VPFTRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRI

--------------------------------------------------------------
>15260_15260_6_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000544843_CDH4_chr20_60503248_ENST00000543233_length(transcript)=2505nt_BP=1219nt
GTGTATGAACGCAGCGGCGGACCTGTGAGGGGATCCGACTTGCCGGCAGAACTTACGCTGCGGGACCCCGGGCACTGTTGCTGCTGCGGG
AGACTGTGGGCTGTTTAGTGCCATGCACCCTTTACAGTGTGTCCTCCAAGTGCAGAGGTCTCTGGGGTGGGGACCATTGGCCTCTGTGTC
TTGGCTGTCGCTGAGGATGTGCAGGGCACACAGCAGTCTCTCTAGTACCATGTGTCCCAGTCCAGAGAGGCAGGAGGATGGAGCTCGGAA
GGATTTCAGCTCCAGGCTGGCTGCTGGACCGACTTTTCAACATTTTTTAAAAAGTGCCTCAGCTCCTCAGGAGAAGCTGTCTTCAGAAGT
GGAAGACCCACCTCCCTATCTCATGATGGATGAACTTCTTGGAAGGCAGAGAAAAGTCTACCTCGAGACCTATGGCTGCCAGATGAATGT
GAATGACACAGAGATAGCCTGGTCCATCTTACAGAAGAGTGGCTACCTGCGGACCAGTAACCTCCAAGAGGCAGATGTGATTCTCCTTGT
CACATGCTCTATCAGGGAGAAGGCTGAGCAGACCATCTGGAACCGTTTACATCAGCTTAAAGCCTTGAAGACAAGGCGGCCCCGCTCCCG
GGTTCCTCTGAGGATTGGAATTCTAGGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAGATATTTTGGC
TGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCTCTCTGGACGA
GACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACAACATGTGTAG
CTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTTCTGAGCAGGG
GCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGCCTACCAATCT
CAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAGTAGATCCTGA
AATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGAGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTAT
CTCATTGACATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGAGGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACG
GCGGCCGACGCTGACGTCGACCCCAACATCGGCCCCTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATC
ACCCGCCTGAACGGTGACTATGCCCAACTCAGCTTGCGCATCCTGTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGAC
TCTGGAAACCCTCCCCTGTCCAACACGTCCATCATCAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCA
GTGGCAGCGGCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCTCATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATG
TGGATGAAGCGGCGAGAGAAGGAGCGCCACACGAAGCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGAC
GAGGAAGGCGGTGGCGAGGAGGACCAGGACTACGACCTCAGCCAGCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCT
GGCGTGCGTCGCGTGGATGAGCGGCCGGTGGGCGCTGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGAC
TTCATCAATGAGGGACTCCGCGCTGCTGACAACGACCCCACGGCACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGC
TCCACCGCAGGCTCCGTCAGCTCCCTGAACTCATCCAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAG
AAGCTGGCGGACATGTATGGAGGTGGTGAAGAGGATTGACTGACCTCGCATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGG
AGCAGGACTGAGCAGAGGCGGCCGGTCTTCCCGACTCCCTGCGGCTGTGTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAG
CTGTCTAGCATGAGCACCCACCCCCACAGCGCCCTGCACCCGGCCGCTGCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGC

>15260_15260_6_CDK5RAP1-CDH4_CDK5RAP1_chr20_31967267_ENST00000544843_CDH4_chr20_60503248_ENST00000543233_length(amino acids)=410AA_BP=373
MFSAMHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDP
PPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPL
RIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCI
VPFTRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDK5RAP1-CDH4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDK5RAP1-CDH4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDK5RAP1-CDH4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource