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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CDK6-HEPACAM2 (FusionGDB2 ID:15291)

Fusion Gene Summary for CDK6-HEPACAM2

Fusion gene summary

Fusion gene information	Fusion gene name: CDK6-HEPACAM2
	Fusion gene ID: 15291
		Hgene	Tgene
	Gene symbol	CDK6	HEPACAM2
	Gene ID	1021	253012
	Gene name	cyclin dependent kinase 6	HEPACAM family member 2
	Synonyms	MCPH12\|PLSTIRE	MIKI
	Cytomap	7q21.2	7q21.2
	Type of gene	protein-coding	protein-coding
	Description	cyclin-dependent kinase 6cell division protein kinase 6serine/threonine-protein kinase PLSTIRE	HEPACAM family member 2mitotic kinetics regulator
	Modification date	20200329	20200313
	UniProtAcc	Q00534	A8MVW5
	Ensembl transtripts involved in fusion gene	ENST00000265734, ENST00000424848, ENST00000491250,	ENST00000492616, ENST00000341723, ENST00000394468, ENST00000440868, ENST00000453812,
Fusion gene scores	* DoF score	12 X 9 X 7=756	2 X 3 X 2=12
	# samples	17	4
	** MAII score	log2(17/756*10)=-2.15285148808337 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CDK6 [Title/Abstract] AND HEPACAM2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CDK6(92404010)-HEPACAM2(92821676), # samples:3
Anticipated loss of major functional domain due to fusion event.	CDK6-HEPACAM2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CDK6-HEPACAM2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CDK6-HEPACAM2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. CDK6-HEPACAM2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CDK6-HEPACAM2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDK6	GO:0001954	positive regulation of cell-matrix adhesion	10205165
Hgene	CDK6	GO:0003323	type B pancreatic cell development	20668294
Hgene	CDK6	GO:0006468	protein phosphorylation	8114739
Hgene	CDK6	GO:0010468	regulation of gene expression	15254224
Hgene	CDK6	GO:0045638	negative regulation of myeloid cell differentiation	17431401
Hgene	CDK6	GO:0045656	negative regulation of monocyte differentiation	26542173
Hgene	CDK6	GO:0045668	negative regulation of osteoblast differentiation	15254224
Hgene	CDK6	GO:0045786	negative regulation of cell cycle	14985467
Hgene	CDK6	GO:2000773	negative regulation of cellular senescence	17420273

Fusion gene breakpoints across CDK6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HEPACAM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-G2-A2EF-01A	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
ChimerDB4	BLCA	TCGA-G2-A2EF	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-

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Fusion Gene ORF analysis for CDK6-HEPACAM2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000265734	ENST00000492616	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
5CDS-5UTR	ENST00000265734	ENST00000492616	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
5CDS-5UTR	ENST00000424848	ENST00000492616	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
5CDS-5UTR	ENST00000424848	ENST00000492616	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
Frame-shift	ENST00000265734	ENST00000341723	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
Frame-shift	ENST00000265734	ENST00000341723	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
Frame-shift	ENST00000265734	ENST00000394468	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
Frame-shift	ENST00000265734	ENST00000394468	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
Frame-shift	ENST00000265734	ENST00000440868	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
Frame-shift	ENST00000265734	ENST00000440868	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
Frame-shift	ENST00000265734	ENST00000453812	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
Frame-shift	ENST00000265734	ENST00000453812	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
Frame-shift	ENST00000424848	ENST00000440868	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
Frame-shift	ENST00000424848	ENST00000440868	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
In-frame	ENST00000424848	ENST00000341723	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
In-frame	ENST00000424848	ENST00000341723	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
In-frame	ENST00000424848	ENST00000394468	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
In-frame	ENST00000424848	ENST00000394468	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
In-frame	ENST00000424848	ENST00000453812	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
In-frame	ENST00000424848	ENST00000453812	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
intron-3CDS	ENST00000491250	ENST00000341723	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
intron-3CDS	ENST00000491250	ENST00000341723	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
intron-3CDS	ENST00000491250	ENST00000394468	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
intron-3CDS	ENST00000491250	ENST00000394468	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
intron-3CDS	ENST00000491250	ENST00000440868	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
intron-3CDS	ENST00000491250	ENST00000440868	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
intron-3CDS	ENST00000491250	ENST00000453812	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
intron-3CDS	ENST00000491250	ENST00000453812	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-
intron-5UTR	ENST00000491250	ENST00000492616	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-
intron-5UTR	ENST00000491250	ENST00000492616	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000424848	CDK6	chr7	92404010	-	ENST00000341723	HEPACAM2	chr7	92821676	-	1648	853	484	966	160
ENST00000424848	CDK6	chr7	92404010	-	ENST00000394468	HEPACAM2	chr7	92821676	-	1648	853	484	966	160
ENST00000424848	CDK6	chr7	92404010	-	ENST00000453812	HEPACAM2	chr7	92821676	-	1355	853	484	966	160
ENST00000424848	CDK6	chr7	92404009	-	ENST00000341723	HEPACAM2	chr7	92821676	-	1648	853	484	966	160
ENST00000424848	CDK6	chr7	92404009	-	ENST00000394468	HEPACAM2	chr7	92821676	-	1648	853	484	966	160
ENST00000424848	CDK6	chr7	92404009	-	ENST00000453812	HEPACAM2	chr7	92821676	-	1355	853	484	966	160

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000424848	ENST00000341723	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-	0.002817288	0.9971827
ENST00000424848	ENST00000394468	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-	0.002817288	0.9971827
ENST00000424848	ENST00000453812	CDK6	chr7	92404010	-	HEPACAM2	chr7	92821676	-	0.006737512	0.99326247
ENST00000424848	ENST00000341723	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-	0.002817288	0.9971827
ENST00000424848	ENST00000394468	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-	0.002817288	0.9971827
ENST00000424848	ENST00000453812	CDK6	chr7	92404009	-	HEPACAM2	chr7	92821676	-	0.006737512	0.99326247

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Fusion Genomic Features for CDK6-HEPACAM2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDK6-HEPACAM2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:92404010/chr7:92821676)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDK6 Q00534	HEPACAM2 A8MVW5
FUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269\|PubMed:12833137, ECO:0000269\|PubMed:14985467, ECO:0000269\|PubMed:15254224, ECO:0000269\|PubMed:15809340, ECO:0000269\|PubMed:17420273, ECO:0000269\|PubMed:17431401, ECO:0000269\|PubMed:20333249, ECO:0000269\|PubMed:20668294, ECO:0000269\|PubMed:23918663, ECO:0000269\|PubMed:8114739}.	FUNCTION: Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. {ECO:0000269\|PubMed:22864114}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDK6

chr7:92404009

chr7:92821676

ENST00000265734

19_27

123

327.0

Nucleotide binding

ATP

Hgene

CDK6

chr7:92404009

chr7:92821676

ENST00000424848

19_27

123

327.0

Nucleotide binding

ATP

Hgene

CDK6

chr7:92404010

chr7:92821676

ENST00000265734

19_27

123

327.0

Nucleotide binding

ATP

Hgene

CDK6

chr7:92404010

chr7:92821676

ENST00000424848

19_27

123

327.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDK6

chr7:92404009

chr7:92821676

ENST00000265734

13_300

123

327.0

Domain

Protein kinase

Hgene

CDK6

chr7:92404009

chr7:92821676

ENST00000424848

13_300

123

327.0

Domain

Protein kinase

Hgene

CDK6

chr7:92404010

chr7:92821676

ENST00000265734

13_300

123

327.0

Domain

Protein kinase

Hgene

CDK6

chr7:92404010

chr7:92821676

ENST00000424848

13_300

123

327.0

Domain

Protein kinase

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000341723

149_233

413

451.0

Domain

Note=Ig-like C2-type 1

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000341723

235_331

413

451.0

Domain

Note=Ig-like C2-type 2

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000394468

149_233

425

463.0

Domain

Note=Ig-like C2-type 1

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000394468

235_331

425

463.0

Domain

Note=Ig-like C2-type 2

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000453812

149_233

448

486.0

Domain

Note=Ig-like C2-type 1

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000453812

235_331

448

486.0

Domain

Note=Ig-like C2-type 2

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000341723

149_233

413

451.0

Domain

Note=Ig-like C2-type 1

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000341723

235_331

413

451.0

Domain

Note=Ig-like C2-type 2

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000394468

149_233

425

463.0

Domain

Note=Ig-like C2-type 1

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000394468

235_331

425

463.0

Domain

Note=Ig-like C2-type 2

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000453812

149_233

448

486.0

Domain

Note=Ig-like C2-type 1

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000453812

235_331

448

486.0

Domain

Note=Ig-like C2-type 2

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000341723

373_462

413

451.0

Topological domain

Cytoplasmic

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000394468

373_462

425

463.0

Topological domain

Cytoplasmic

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000453812

373_462

448

486.0

Topological domain

Cytoplasmic

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000341723

373_462

413

451.0

Topological domain

Cytoplasmic

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000394468

373_462

425

463.0

Topological domain

Cytoplasmic

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000453812

373_462

448

486.0

Topological domain

Cytoplasmic

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000341723

352_372

413

451.0

Transmembrane

Helical

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000394468

352_372

425

463.0

Transmembrane

Helical

Tgene

HEPACAM2

chr7:92404009

chr7:92821676

ENST00000453812

352_372

448

486.0

Transmembrane

Helical

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000341723

352_372

413

451.0

Transmembrane

Helical

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000394468

352_372

425

463.0

Transmembrane

Helical

Tgene

HEPACAM2

chr7:92404010

chr7:92821676

ENST00000453812

352_372

448

486.0

Transmembrane

Helical

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Fusion Gene Sequence for CDK6-HEPACAM2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>15291_15291_1_CDK6-HEPACAM2_CDK6_chr7_92404009_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000341723_length(transcript)=1648nt_BP=853nt
GCTGGTAACTCCTTCCCCAGAGTCTGATTACCTGCTCCGCGAGGCCGCGGACACGTGCGGAGAGCCGACTGACACTCGCAGCCCCCTCGG
GAGGCCCGACGCGACTGGGCCCCTCAGGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTAATCGTGTCTGTGTTGAGG
ACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAGGCGGAGTTTCGCGGCGGC
GGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGCCCGAGCGCCTGAGCCGGC
GGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGAGCGCACCCCCCGCCCGCC
CCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGAT
CGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGAC
CGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGGTT
GTTTGATGTGTGCACAGTGTCACGAACAGACAGAGAAACCAAACTAACTTTAGTGTTTGAACATGTCGATCAAGACTTGACCACTTACTT
GGATAAAGTTCCAGAGCCTGGAGTGCCCACTGAAACCATAAAGATCCCAAGCAGGTCTGTTCCAGCCTCTGATTGTGTATCGGGGCAAGA
TTTGCACAGTACAGTGTATGAAGTTATTCAGCACATCCCTGCCCAGCAGCAAGACCATCCAGAGTGAACTTTCATGGGCTAAACAGTACA
TTCGAGTGAAATTCTGAAGAAACATTTTAAGGAAAAACAGTGGAAAAGTATATTAATCTGGAATCAGTGAAGAAACCAAGACCAACACCT
CTTACTCATTATTCCTTTACATGCAGAATAGAGGCATTTATGCAAATTGAACTGCAGGTTTTTCAGCATATACACAATGTCTTGTGCAAC
AGAAAAACATGTTGGGGAAATATTCCTCAGTGGAGAGTCGTTCTCATGCTGACGGGGAGAACGAAAGTGACAGGGGTTTCCTCATAAGTT
TTGTATGAAATATCTCTACAAACCTCAATTAGTTCTACTCTACACTTTCACTATCATCAACACTGAGACTATCCTGTCTCACCTACAAAT
GTGGAAACTTTACATTGTTCGATTTTTCAGCAGACTTTGTTTTATTAAATTTTTATTAGTGTTAAGAATGCTAAATTTATGTTTCAATTT
TATTTCCAAATTTCTATCTTGTTATTTGTACAACAAAGTAATAAGGATGGTTGTCACAAAAACAAAACTATGCCTTCTCTTTTTTTTCAA
TCACCAGTAGTATTTTTGAGAAGACTTGTGAACACTTAAGGAAATGACTATTAAAGTCTTATTTTTATTTTTTTCAAGGAAAGATGGATT

>15291_15291_1_CDK6-HEPACAM2_CDK6_chr7_92404009_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000341723_length(amino acids)=160AA_BP=123
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR

--------------------------------------------------------------
>15291_15291_2_CDK6-HEPACAM2_CDK6_chr7_92404009_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000394468_length(transcript)=1648nt_BP=853nt
GCTGGTAACTCCTTCCCCAGAGTCTGATTACCTGCTCCGCGAGGCCGCGGACACGTGCGGAGAGCCGACTGACACTCGCAGCCCCCTCGG
GAGGCCCGACGCGACTGGGCCCCTCAGGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTAATCGTGTCTGTGTTGAGG
ACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAGGCGGAGTTTCGCGGCGGC
GGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGCCCGAGCGCCTGAGCCGGC
GGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGAGCGCACCCCCCGCCCGCC
CCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGAT
CGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGAC
CGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGGTT
GTTTGATGTGTGCACAGTGTCACGAACAGACAGAGAAACCAAACTAACTTTAGTGTTTGAACATGTCGATCAAGACTTGACCACTTACTT
GGATAAAGTTCCAGAGCCTGGAGTGCCCACTGAAACCATAAAGATCCCAAGCAGGTCTGTTCCAGCCTCTGATTGTGTATCGGGGCAAGA
TTTGCACAGTACAGTGTATGAAGTTATTCAGCACATCCCTGCCCAGCAGCAAGACCATCCAGAGTGAACTTTCATGGGCTAAACAGTACA
TTCGAGTGAAATTCTGAAGAAACATTTTAAGGAAAAACAGTGGAAAAGTATATTAATCTGGAATCAGTGAAGAAACCAAGACCAACACCT
CTTACTCATTATTCCTTTACATGCAGAATAGAGGCATTTATGCAAATTGAACTGCAGGTTTTTCAGCATATACACAATGTCTTGTGCAAC
AGAAAAACATGTTGGGGAAATATTCCTCAGTGGAGAGTCGTTCTCATGCTGACGGGGAGAACGAAAGTGACAGGGGTTTCCTCATAAGTT
TTGTATGAAATATCTCTACAAACCTCAATTAGTTCTACTCTACACTTTCACTATCATCAACACTGAGACTATCCTGTCTCACCTACAAAT
GTGGAAACTTTACATTGTTCGATTTTTCAGCAGACTTTGTTTTATTAAATTTTTATTAGTGTTAAGAATGCTAAATTTATGTTTCAATTT
TATTTCCAAATTTCTATCTTGTTATTTGTACAACAAAGTAATAAGGATGGTTGTCACAAAAACAAAACTATGCCTTCTCTTTTTTTTCAA
TCACCAGTAGTATTTTTGAGAAGACTTGTGAACACTTAAGGAAATGACTATTAAAGTCTTATTTTTATTTTTTTCAAGGAAAGATGGATT

>15291_15291_2_CDK6-HEPACAM2_CDK6_chr7_92404009_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000394468_length(amino acids)=160AA_BP=123
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR

--------------------------------------------------------------
>15291_15291_3_CDK6-HEPACAM2_CDK6_chr7_92404009_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000453812_length(transcript)=1355nt_BP=853nt
GCTGGTAACTCCTTCCCCAGAGTCTGATTACCTGCTCCGCGAGGCCGCGGACACGTGCGGAGAGCCGACTGACACTCGCAGCCCCCTCGG
GAGGCCCGACGCGACTGGGCCCCTCAGGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTAATCGTGTCTGTGTTGAGG
ACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAGGCGGAGTTTCGCGGCGGC
GGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGCCCGAGCGCCTGAGCCGGC
GGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGAGCGCACCCCCCGCCCGCC
CCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGAT
CGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGAC
CGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGGTT
GTTTGATGTGTGCACAGTGTCACGAACAGACAGAGAAACCAAACTAACTTTAGTGTTTGAACATGTCGATCAAGACTTGACCACTTACTT
GGATAAAGTTCCAGAGCCTGGAGTGCCCACTGAAACCATAAAGATCCCAAGCAGGTCTGTTCCAGCCTCTGATTGTGTATCGGGGCAAGA
TTTGCACAGTACAGTGTATGAAGTTATTCAGCACATCCCTGCCCAGCAGCAAGACCATCCAGAGTGAACTTTCATGGGCTAAACAGTACA
TTCGAGTGAAATTCTGAAGAAACATTTTAAGGAAAAACAGTGGAAAAGTATATTAATCTGGAATCAGTGAAGAAACCAAGACCAACACCT
CTTACTCATTATTCCTTTACATGCAGAATAGAGGCATTTATGCAAATTGAACTGCAGGTTTTTCAGCATATACACAATGTCTTGTGCAAC
AGAAAAACATGTTGGGGAAATATTCCTCAGTGGAGAGTCGTTCTCATGCTGACGGGGAGAACGAAAGTGACAGGGGTTTCCTCATAAGTT
TTGTATGAAATATCTCTACAAACCTCAATTAGTTCTACTCTACACTTTCACTATCATCAACACTGAGACTATCCTGTCTCACCTACAAAT

>15291_15291_3_CDK6-HEPACAM2_CDK6_chr7_92404009_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000453812_length(amino acids)=160AA_BP=123
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR

--------------------------------------------------------------
>15291_15291_4_CDK6-HEPACAM2_CDK6_chr7_92404010_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000341723_length(transcript)=1648nt_BP=853nt
GCTGGTAACTCCTTCCCCAGAGTCTGATTACCTGCTCCGCGAGGCCGCGGACACGTGCGGAGAGCCGACTGACACTCGCAGCCCCCTCGG
GAGGCCCGACGCGACTGGGCCCCTCAGGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTAATCGTGTCTGTGTTGAGG
ACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAGGCGGAGTTTCGCGGCGGC
GGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGCCCGAGCGCCTGAGCCGGC
GGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGAGCGCACCCCCCGCCCGCC
CCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGAT
CGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGAC
CGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGGTT
GTTTGATGTGTGCACAGTGTCACGAACAGACAGAGAAACCAAACTAACTTTAGTGTTTGAACATGTCGATCAAGACTTGACCACTTACTT
GGATAAAGTTCCAGAGCCTGGAGTGCCCACTGAAACCATAAAGATCCCAAGCAGGTCTGTTCCAGCCTCTGATTGTGTATCGGGGCAAGA
TTTGCACAGTACAGTGTATGAAGTTATTCAGCACATCCCTGCCCAGCAGCAAGACCATCCAGAGTGAACTTTCATGGGCTAAACAGTACA
TTCGAGTGAAATTCTGAAGAAACATTTTAAGGAAAAACAGTGGAAAAGTATATTAATCTGGAATCAGTGAAGAAACCAAGACCAACACCT
CTTACTCATTATTCCTTTACATGCAGAATAGAGGCATTTATGCAAATTGAACTGCAGGTTTTTCAGCATATACACAATGTCTTGTGCAAC
AGAAAAACATGTTGGGGAAATATTCCTCAGTGGAGAGTCGTTCTCATGCTGACGGGGAGAACGAAAGTGACAGGGGTTTCCTCATAAGTT
TTGTATGAAATATCTCTACAAACCTCAATTAGTTCTACTCTACACTTTCACTATCATCAACACTGAGACTATCCTGTCTCACCTACAAAT
GTGGAAACTTTACATTGTTCGATTTTTCAGCAGACTTTGTTTTATTAAATTTTTATTAGTGTTAAGAATGCTAAATTTATGTTTCAATTT
TATTTCCAAATTTCTATCTTGTTATTTGTACAACAAAGTAATAAGGATGGTTGTCACAAAAACAAAACTATGCCTTCTCTTTTTTTTCAA
TCACCAGTAGTATTTTTGAGAAGACTTGTGAACACTTAAGGAAATGACTATTAAAGTCTTATTTTTATTTTTTTCAAGGAAAGATGGATT

>15291_15291_4_CDK6-HEPACAM2_CDK6_chr7_92404010_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000341723_length(amino acids)=160AA_BP=123
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR

--------------------------------------------------------------
>15291_15291_5_CDK6-HEPACAM2_CDK6_chr7_92404010_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000394468_length(transcript)=1648nt_BP=853nt
GCTGGTAACTCCTTCCCCAGAGTCTGATTACCTGCTCCGCGAGGCCGCGGACACGTGCGGAGAGCCGACTGACACTCGCAGCCCCCTCGG
GAGGCCCGACGCGACTGGGCCCCTCAGGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTAATCGTGTCTGTGTTGAGG
ACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAGGCGGAGTTTCGCGGCGGC
GGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGCCCGAGCGCCTGAGCCGGC
GGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGAGCGCACCCCCCGCCCGCC
CCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGAT
CGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGAC
CGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGGTT
GTTTGATGTGTGCACAGTGTCACGAACAGACAGAGAAACCAAACTAACTTTAGTGTTTGAACATGTCGATCAAGACTTGACCACTTACTT
GGATAAAGTTCCAGAGCCTGGAGTGCCCACTGAAACCATAAAGATCCCAAGCAGGTCTGTTCCAGCCTCTGATTGTGTATCGGGGCAAGA
TTTGCACAGTACAGTGTATGAAGTTATTCAGCACATCCCTGCCCAGCAGCAAGACCATCCAGAGTGAACTTTCATGGGCTAAACAGTACA
TTCGAGTGAAATTCTGAAGAAACATTTTAAGGAAAAACAGTGGAAAAGTATATTAATCTGGAATCAGTGAAGAAACCAAGACCAACACCT
CTTACTCATTATTCCTTTACATGCAGAATAGAGGCATTTATGCAAATTGAACTGCAGGTTTTTCAGCATATACACAATGTCTTGTGCAAC
AGAAAAACATGTTGGGGAAATATTCCTCAGTGGAGAGTCGTTCTCATGCTGACGGGGAGAACGAAAGTGACAGGGGTTTCCTCATAAGTT
TTGTATGAAATATCTCTACAAACCTCAATTAGTTCTACTCTACACTTTCACTATCATCAACACTGAGACTATCCTGTCTCACCTACAAAT
GTGGAAACTTTACATTGTTCGATTTTTCAGCAGACTTTGTTTTATTAAATTTTTATTAGTGTTAAGAATGCTAAATTTATGTTTCAATTT
TATTTCCAAATTTCTATCTTGTTATTTGTACAACAAAGTAATAAGGATGGTTGTCACAAAAACAAAACTATGCCTTCTCTTTTTTTTCAA
TCACCAGTAGTATTTTTGAGAAGACTTGTGAACACTTAAGGAAATGACTATTAAAGTCTTATTTTTATTTTTTTCAAGGAAAGATGGATT

>15291_15291_5_CDK6-HEPACAM2_CDK6_chr7_92404010_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000394468_length(amino acids)=160AA_BP=123
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR

--------------------------------------------------------------
>15291_15291_6_CDK6-HEPACAM2_CDK6_chr7_92404010_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000453812_length(transcript)=1355nt_BP=853nt
GCTGGTAACTCCTTCCCCAGAGTCTGATTACCTGCTCCGCGAGGCCGCGGACACGTGCGGAGAGCCGACTGACACTCGCAGCCCCCTCGG
GAGGCCCGACGCGACTGGGCCCCTCAGGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTAATCGTGTCTGTGTTGAGG
ACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAGGCGGAGTTTCGCGGCGGC
GGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGCCCGAGCGCCTGAGCCGGC
GGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGAGCGCACCCCCCGCCCGCC
CCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGAT
CGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGAC
CGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGGTT
GTTTGATGTGTGCACAGTGTCACGAACAGACAGAGAAACCAAACTAACTTTAGTGTTTGAACATGTCGATCAAGACTTGACCACTTACTT
GGATAAAGTTCCAGAGCCTGGAGTGCCCACTGAAACCATAAAGATCCCAAGCAGGTCTGTTCCAGCCTCTGATTGTGTATCGGGGCAAGA
TTTGCACAGTACAGTGTATGAAGTTATTCAGCACATCCCTGCCCAGCAGCAAGACCATCCAGAGTGAACTTTCATGGGCTAAACAGTACA
TTCGAGTGAAATTCTGAAGAAACATTTTAAGGAAAAACAGTGGAAAAGTATATTAATCTGGAATCAGTGAAGAAACCAAGACCAACACCT
CTTACTCATTATTCCTTTACATGCAGAATAGAGGCATTTATGCAAATTGAACTGCAGGTTTTTCAGCATATACACAATGTCTTGTGCAAC
AGAAAAACATGTTGGGGAAATATTCCTCAGTGGAGAGTCGTTCTCATGCTGACGGGGAGAACGAAAGTGACAGGGGTTTCCTCATAAGTT
TTGTATGAAATATCTCTACAAACCTCAATTAGTTCTACTCTACACTTTCACTATCATCAACACTGAGACTATCCTGTCTCACCTACAAAT

>15291_15291_6_CDK6-HEPACAM2_CDK6_chr7_92404010_ENST00000424848_HEPACAM2_chr7_92821676_ENST00000453812_length(amino acids)=160AA_BP=123
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CDK6-HEPACAM2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CDK6-HEPACAM2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CDK6-HEPACAM2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source