Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CDKAL1-CNNM4 (FusionGDB2 ID:15326)

Fusion Gene Summary for CDKAL1-CNNM4

Fusion gene summary

Fusion gene information	Fusion gene name: CDKAL1-CNNM4
	Fusion gene ID: 15326
		Hgene	Tgene
	Gene symbol	CDKAL1	CNNM4
	Gene ID	54901	26504
	Gene name	CDK5 regulatory subunit associated protein 1 like 1	cyclin and CBS domain divalent metal cation transport mediator 4
	Synonyms	-	ACDP4
	Cytomap	6p22.3	2q11.2
	Type of gene	protein-coding	protein-coding
	Description	threonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferase	metal transporter CNNM4ancient conserved domain protein 4ancient conserved domain-containing protein 4cyclin-M4
	Modification date	20200322	20200313
	UniProtAcc	.	Q6P4Q7
	Ensembl transtripts involved in fusion gene	ENST00000274695, ENST00000378610, ENST00000378624, ENST00000476517,	ENST00000496186, ENST00000540067, ENST00000377075,
Fusion gene scores	* DoF score	37 X 20 X 14=10360	4 X 5 X 2=40
	# samples	39	5
	** MAII score	log2(39/10360*10)=-4.73140606882431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CDKAL1 [Title/Abstract] AND CNNM4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CDKAL1(20548923)-CNNM4(97427351), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CNNM4	GO:0055065	metal ion homeostasis	15840172

Fusion gene breakpoints across CDKAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CNNM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BP350154	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+

Top

Fusion Gene ORF analysis for CDKAL1-CNNM4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000274695	ENST00000496186	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
5CDS-intron	ENST00000274695	ENST00000540067	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
5CDS-intron	ENST00000378610	ENST00000496186	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
5CDS-intron	ENST00000378610	ENST00000540067	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
In-frame	ENST00000274695	ENST00000377075	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
In-frame	ENST00000378610	ENST00000377075	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
intron-3CDS	ENST00000378624	ENST00000377075	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
intron-3CDS	ENST00000476517	ENST00000377075	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
intron-intron	ENST00000378624	ENST00000496186	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
intron-intron	ENST00000378624	ENST00000540067	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
intron-intron	ENST00000476517	ENST00000496186	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
intron-intron	ENST00000476517	ENST00000540067	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000274695

CDKAL1

chr6

20548923

ENST00000377075

CNNM4

chr2

97427351

4440

353

167

2065

632

ENST00000378610

CDKAL1

chr6

20548923

ENST00000377075

CNNM4

chr2

97427351

4283

196

1908

632

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000274695	ENST00000377075	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+	0.002747928	0.99725205
ENST00000378610	ENST00000377075	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+	0.003147867	0.9968521

Top

Fusion Genomic Features for CDKAL1-CNNM4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CDKAL1-CNNM4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:20548923/chr2:97427351)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CNNM4 Q6P4Q7
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269\|PubMed:19200525, ECO:0000269\|PubMed:19200527}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

178_358

776.0

Domain

CNNM transmembrane

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

377_438

776.0

Domain

CBS 1

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

445_511

776.0

Domain

CBS 2

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

241_261

776.0

Intramembrane

Helical

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

1_178

776.0

Topological domain

Extracellular

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

200_240

776.0

Topological domain

Cytoplasmic

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

262_264

776.0

Topological domain

Cytoplasmic

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

286_293

776.0

Topological domain

Extracellular

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

317_775

776.0

Topological domain

Cytoplasmic

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

179_199

776.0

Transmembrane

Helical

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

265_285

776.0

Transmembrane

Helical

Tgene

CNNM4

chr6:20548923

chr2:97427351

ENST00000377075

294_316

776.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000274695

200_431

580.0

Domain

Radical SAM core

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000274695

431_493

580.0

Domain

TRAM

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000274695

64_172

580.0

Domain

MTTase N-terminal

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000378610

200_431

580.0

Domain

Radical SAM core

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000378610

431_493

580.0

Domain

TRAM

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000378610

64_172

580.0

Domain

MTTase N-terminal

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000378624

200_431

489.0

Domain

Radical SAM core

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000378624

431_493

489.0

Domain

TRAM

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000378624

64_172

489.0

Domain

MTTase N-terminal

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000274695

556_578

580.0

Transmembrane

Helical

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000378610

556_578

580.0

Transmembrane

Helical

Hgene

CDKAL1

chr6:20548923

chr2:97427351

ENST00000378624

556_578

489.0

Transmembrane

Helical

Top

Fusion Gene Sequence for CDKAL1-CNNM4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>15326_15326_1_CDKAL1-CNNM4_CDKAL1_chr6_20548923_ENST00000274695_CNNM4_chr2_97427351_ENST00000377075_length(transcript)=4440nt_BP=353nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGTATAAAATTACAGCTTATGG
CCCTGGACCCCATGGAGCTGCGCATCGTGCAGAACTGTGGCACCGAGAAGGAGAGGCGCTATGCCCGCAAGATTGAGCCCATCCGGCGCA
AGGGCAACTACCTTCTCTGCTCGTTGCTCCTAGGGAACGTGCTGGTCAACACCTCCCTCACAATCCTTCTAGACAACCTCATCGGGTCCG
GCCTCATGGCGGTGGCCTCCTCCACCATTGGCATTGTCATCTTTGGGGAGATCCTACCTCAGGCCCTGTGCTCCCGACATGGGCTGGCTG
TGGGTGCCAACACCATCCTTCTCACCAAATTCTTTATGCTACTCACCTTCCCCCTCAGTTTTCCCATTAGCAAGCTCCTGGACTTTTTTC
TGGGCCAGGAGATTCGCACTGTTTACAACCGGGAGAAGCTGATGGAGATGTTGAAGGTGACGGAGCCCTATAATGACCTCGTGAAAGAGG
AGCTCAATATGATCCAGGGTGCCCTGGAACTACGGACCAAAACTGTAGAGGATATCATGACCCAGCTCCAGGACTGCTTCATGATCCGCA
GCGATGCCATCCTGGACTTCAACACCATGTCGGAGATAATGGAAAGCGGCTATACTCGCATCCCGGTGTTCGAAGACGAGCAGTCCAATA
TTGTAGATATTCTCTACGTCAAAGACTTGGCCTTTGTGGACCCCGATGACTGCACCCCCCTCAAGACTATCACTCGCTTCTATAACCACC
CGGTGCACTTTGTCTTCCATGACACCAAGTTGGATGCCATGCTGGAGGAGTTCAAGAAGGGGAAGTCCCACCTGGCCATCGTGCAGAAGG
TAAACAACGAGGGTGAGGGTGACCCCTTCTACGAGGTCCTGGGCCTGGTCACCCTGGAGGACGTGATCGAGGAGATCATCAAGTCGGAGA
TCCTGGACGAGTCCGACATGTACACTGACAACCGAAGCCGGAAGCGGGTGTCTGAGAAGAACAAGCGTGACTTCTCTGCCTTCAAGGATG
CGGACAATGAGCTCAAAGTGAAAATCTCCCCGCAGCTCCTCCTGGCCGCTCATCGCTTCCTAGCCACAGAGGTCTCTCAGTTTAGCCCCT
CCCTGATATCAGAGAAGATCCTGCTGCGGCTACTCAAGTACCCAGATGTCATTCAGGAACTCAAGTTTGACGAGCACAATAAGTACTACG
CCCGCCATTACCTGTACACCCGAAATAAGCCGGCCGACTACTTCATCCTCATCCTGCAGGGGAAGGTGGAGGTGGAGGCAGGGAAGGAGA
ACATGAAGTTTGAGACGGGCGCCTTCTCCTACTATGGGACTATGGCCCTGACCTCGGTCCCCTCCGACCGTTCCCCAGCACACCCCACCC
CACTCAGCCGCTCAGCCTCCCTCAGTTACCCAGACCGCACAGACGTCTCAACTGCAGCAACCTTGGCAGGCAGCAGCAACCAGTTTGGCA
GCTCTGTCCTGGGCCAGTACATCTCTGACTTCAGCGTCCGGGCACTCGTGGACTTGCAGTACATCAAGATCACTCGGCAGCAGTACCAGA
ACGGGCTGCTGGCTTCTCGCATGGAGAACAGCCCTCAGTTTCCCATAGACGGGTGCACCACCCACATGGAGAACTTGGCCGAGAAGTCTG
AGCTGCCTGTGGTGGACGAGACCACAACTCTTCTCAACGAGCGTAACTCCTTGCTGCACAAAGCCTCCCACGAGAATGCCATCTGACAGG
AGGGCCCGGGGCCCCCTGCCCACCCTGCGGGGGCCTCCCCAGTGGGCCCACATGAAGAGAGGGAACCTGTTAGTCCAGAAAGGATACGGA
TAGATAGCCTGTCTGACTGAACAGCCAGATGGCCCCCAGCCTATGGGGGATCTGGCCTCTGCCAGGGACCTCTGAGTAGCTCTGAGGTGG
CACTGTCCAGCCCTGGATAGGGGGGGCAGTGGGCCAGCTACCGTAAGCAAAGGCTGTTTTTTACTGAGAGAATTTCTAAAGTAGGCTCAT
CACTTTTTTTTAAATATCATTTTGGGAAGGGAAGACAGGGTTAAGGAACTTTATTTAAAAAAAAAATATTTTTTTCCTAAAAACTATAAA
AGAGGAAGGGTTTCTTGTCCCGGGAAGCAACGGACATAATCTGTTCCCAGCCATGGCCTTCCAGCTTGTGTCCCTGATTCAGGGAGCTCT
CCCTTCCTCCTCCTCCTCCTCCTCCGGAGGTGGGATCCCAGAGCCTGCCAGTGGAGGCTTATCTGTTGGGAGGAAGACAGCTCTTCACAG
AAGCAAAGAACAAAATGGCATGGAGATCAGCTGCCTGAGCACCTGCGCTGTAGCTTATCTGACAACGCTGAGGCCACGAGCTCCTGGGTA
GCTGTGATCAGGGACATGATAATCTGAGCTATGCAGAGGAGCACATCTGTTGTCAACTGCTGTACCCAGAAATCTAGAACTCTGCCGACA
GCCTCTCCTGGTGAGTCGGGACTCAGCTGAGGACACATCCCCACCCTGCCTCCCATCTGGCCCTTTGGACAACTGGCCCTTTGTGACAGG
GCTGACTCAAGTGTTAGGCAGGGTCTCAGGCCTTTGATTGCTCACCCCTGCTCCCCAGGCCCTGCCCTCACTTTTACCAAAGGTTCTCCC
TCGGCGGGAGGGCATCTGTGTTGGAGGTGATTTGTCTGGGTTCTTCCTTTTGGTTCCAGAAGGAACTGTCAGTCATCAGCATCTGCGTTG
TTAGCAGTCAGTACCACCCCCGCCCCACAATGACAGTCAAGGCTGACTTGTTGACTGAAGCCTTTTTCCCAGACCCCTTATTTCGAATCC
CCAAGCTTCAGTCCCTCTTGGGGGTGGAGACAAGAGGACATGTGGGAAGCCACGGAAGCAGGTTCTTTATGTCCTCTCCTCTGTGGCTGG
CAAGGCTCACCTGGCCTTATCCACCCACTTATGGAACCTCAGGAGAGGAGGGCTCCTCCTAAAGGCATGCAGCTTGCAGCCCCTCTTTCT
CACACGTGTGATCCTAGCGTGAGAGGTCATCCTGCCCTTGCTGAAGTTAGTAGTACTGTACTAAGAGCTCTGCCCTCATGTGAATTCCTG
CCCTGGCGCCTCTTCCCTGGGGCTGAATCAGGCCCTGCTGCAAAACTCCAGGCTTCCCAGGGTTGGGGAGGCTGTGGGACCAAGGTCCAT
GTTGGTCCTTCCACTGGGTGCAGCAGGAGCTGGGTCCCGAGAGCCTGGCAGGTGAAACTCTGCAGGCCTTCCGCCTGATTATTATTTATT
CACTCCTTTCCTCACCCCAAGTGCCCTGCTCTCCAGGTGCCTAGAGTATCCTAACTCTTAGGACCAGGGATTGTCTTGCACCAAGTATGC
CTACCCCTGGCCAGTCTGAGGTCTCCTAGCCATAGAACTGACTCCTGGAAGCCTGGAGAGAAGGTGGTGACACCCATGGGTTCTCAACTG
TAAGGAAAAAAGACACCAGACTTTTGTTCCCTAGTGGGGGAAAGCCCTTAGTCTTGTACAGGAGCAGCTTGCTCCCAAGTCCTTTTGGAA
GCTGGCAGAGCTATATTCCTGACAGCCCTGACTGCCAGGTAGAGCAAAAGACATTGGTGGGGGTATGTGAAGCAAAAGGGGCAGGTGCAC
ACACCTCCACAGTGACCTCTGTGCACACGGTTACCACCAACTGGCTGGCCCTCCTCCTCTTCCCTGGCCCATTGATCATCCCTTCTCACA
GAGGGTCATCATTATTTCCAAATATTGTTTGTCTGATGACTTCCTCTTCCCAGTGCAATTTTTCCCTTCCTATTTCAACCTCTGGTTCCT
GGGATGAGCCATACCCTGGAACTGGCCCACCCACTGTGTCTTCCACGTAAGGGAGACCTTTGCAAAGGGCATCCAAATGGGTAGGCAGGT
GACAGCCGCCGTATTTATTTTGCATAATATTTTAATTTGTATATTTTTGTGATTTATTTTGGCGTTATGAGTTTGACTCTCGGGGAGTTT
TGTTGTTATGACTCTTGTGTCTTTTGTCACAAAACAATGATATTTGCTAAACGATATATGGAATTTATTTTTGATTGGTAATAAAAAATC

>15326_15326_1_CDKAL1-CNNM4_CDKAL1_chr6_20548923_ENST00000274695_CNNM4_chr2_97427351_ENST00000377075_length(amino acids)=632AA_BP=60
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSIKLQLMALDPMELRIVQNCGTEKERRYARKIE
PIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGANTILLTKFFMLLTFPLSFPISKL
LDFFLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLQDCFMIRSDAILDFNTMSEIMESGYTRIPVFED
EQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEI
IKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHRFLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEH
NKYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTSVPSDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSS
NQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHKASHEN

--------------------------------------------------------------
>15326_15326_2_CDKAL1-CNNM4_CDKAL1_chr6_20548923_ENST00000378610_CNNM4_chr2_97427351_ENST00000377075_length(transcript)=4283nt_BP=196nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGTATAAAATTACAGCTTATGGCCCTGGACCCCATGGAGCTGCGCATCGTGCAGAACTGTGGCACCGAGAAGGAGAGGCGCTATGCCCG
CAAGATTGAGCCCATCCGGCGCAAGGGCAACTACCTTCTCTGCTCGTTGCTCCTAGGGAACGTGCTGGTCAACACCTCCCTCACAATCCT
TCTAGACAACCTCATCGGGTCCGGCCTCATGGCGGTGGCCTCCTCCACCATTGGCATTGTCATCTTTGGGGAGATCCTACCTCAGGCCCT
GTGCTCCCGACATGGGCTGGCTGTGGGTGCCAACACCATCCTTCTCACCAAATTCTTTATGCTACTCACCTTCCCCCTCAGTTTTCCCAT
TAGCAAGCTCCTGGACTTTTTTCTGGGCCAGGAGATTCGCACTGTTTACAACCGGGAGAAGCTGATGGAGATGTTGAAGGTGACGGAGCC
CTATAATGACCTCGTGAAAGAGGAGCTCAATATGATCCAGGGTGCCCTGGAACTACGGACCAAAACTGTAGAGGATATCATGACCCAGCT
CCAGGACTGCTTCATGATCCGCAGCGATGCCATCCTGGACTTCAACACCATGTCGGAGATAATGGAAAGCGGCTATACTCGCATCCCGGT
GTTCGAAGACGAGCAGTCCAATATTGTAGATATTCTCTACGTCAAAGACTTGGCCTTTGTGGACCCCGATGACTGCACCCCCCTCAAGAC
TATCACTCGCTTCTATAACCACCCGGTGCACTTTGTCTTCCATGACACCAAGTTGGATGCCATGCTGGAGGAGTTCAAGAAGGGGAAGTC
CCACCTGGCCATCGTGCAGAAGGTAAACAACGAGGGTGAGGGTGACCCCTTCTACGAGGTCCTGGGCCTGGTCACCCTGGAGGACGTGAT
CGAGGAGATCATCAAGTCGGAGATCCTGGACGAGTCCGACATGTACACTGACAACCGAAGCCGGAAGCGGGTGTCTGAGAAGAACAAGCG
TGACTTCTCTGCCTTCAAGGATGCGGACAATGAGCTCAAAGTGAAAATCTCCCCGCAGCTCCTCCTGGCCGCTCATCGCTTCCTAGCCAC
AGAGGTCTCTCAGTTTAGCCCCTCCCTGATATCAGAGAAGATCCTGCTGCGGCTACTCAAGTACCCAGATGTCATTCAGGAACTCAAGTT
TGACGAGCACAATAAGTACTACGCCCGCCATTACCTGTACACCCGAAATAAGCCGGCCGACTACTTCATCCTCATCCTGCAGGGGAAGGT
GGAGGTGGAGGCAGGGAAGGAGAACATGAAGTTTGAGACGGGCGCCTTCTCCTACTATGGGACTATGGCCCTGACCTCGGTCCCCTCCGA
CCGTTCCCCAGCACACCCCACCCCACTCAGCCGCTCAGCCTCCCTCAGTTACCCAGACCGCACAGACGTCTCAACTGCAGCAACCTTGGC
AGGCAGCAGCAACCAGTTTGGCAGCTCTGTCCTGGGCCAGTACATCTCTGACTTCAGCGTCCGGGCACTCGTGGACTTGCAGTACATCAA
GATCACTCGGCAGCAGTACCAGAACGGGCTGCTGGCTTCTCGCATGGAGAACAGCCCTCAGTTTCCCATAGACGGGTGCACCACCCACAT
GGAGAACTTGGCCGAGAAGTCTGAGCTGCCTGTGGTGGACGAGACCACAACTCTTCTCAACGAGCGTAACTCCTTGCTGCACAAAGCCTC
CCACGAGAATGCCATCTGACAGGAGGGCCCGGGGCCCCCTGCCCACCCTGCGGGGGCCTCCCCAGTGGGCCCACATGAAGAGAGGGAACC
TGTTAGTCCAGAAAGGATACGGATAGATAGCCTGTCTGACTGAACAGCCAGATGGCCCCCAGCCTATGGGGGATCTGGCCTCTGCCAGGG
ACCTCTGAGTAGCTCTGAGGTGGCACTGTCCAGCCCTGGATAGGGGGGGCAGTGGGCCAGCTACCGTAAGCAAAGGCTGTTTTTTACTGA
GAGAATTTCTAAAGTAGGCTCATCACTTTTTTTTAAATATCATTTTGGGAAGGGAAGACAGGGTTAAGGAACTTTATTTAAAAAAAAAAT
ATTTTTTTCCTAAAAACTATAAAAGAGGAAGGGTTTCTTGTCCCGGGAAGCAACGGACATAATCTGTTCCCAGCCATGGCCTTCCAGCTT
GTGTCCCTGATTCAGGGAGCTCTCCCTTCCTCCTCCTCCTCCTCCTCCGGAGGTGGGATCCCAGAGCCTGCCAGTGGAGGCTTATCTGTT
GGGAGGAAGACAGCTCTTCACAGAAGCAAAGAACAAAATGGCATGGAGATCAGCTGCCTGAGCACCTGCGCTGTAGCTTATCTGACAACG
CTGAGGCCACGAGCTCCTGGGTAGCTGTGATCAGGGACATGATAATCTGAGCTATGCAGAGGAGCACATCTGTTGTCAACTGCTGTACCC
AGAAATCTAGAACTCTGCCGACAGCCTCTCCTGGTGAGTCGGGACTCAGCTGAGGACACATCCCCACCCTGCCTCCCATCTGGCCCTTTG
GACAACTGGCCCTTTGTGACAGGGCTGACTCAAGTGTTAGGCAGGGTCTCAGGCCTTTGATTGCTCACCCCTGCTCCCCAGGCCCTGCCC
TCACTTTTACCAAAGGTTCTCCCTCGGCGGGAGGGCATCTGTGTTGGAGGTGATTTGTCTGGGTTCTTCCTTTTGGTTCCAGAAGGAACT
GTCAGTCATCAGCATCTGCGTTGTTAGCAGTCAGTACCACCCCCGCCCCACAATGACAGTCAAGGCTGACTTGTTGACTGAAGCCTTTTT
CCCAGACCCCTTATTTCGAATCCCCAAGCTTCAGTCCCTCTTGGGGGTGGAGACAAGAGGACATGTGGGAAGCCACGGAAGCAGGTTCTT
TATGTCCTCTCCTCTGTGGCTGGCAAGGCTCACCTGGCCTTATCCACCCACTTATGGAACCTCAGGAGAGGAGGGCTCCTCCTAAAGGCA
TGCAGCTTGCAGCCCCTCTTTCTCACACGTGTGATCCTAGCGTGAGAGGTCATCCTGCCCTTGCTGAAGTTAGTAGTACTGTACTAAGAG
CTCTGCCCTCATGTGAATTCCTGCCCTGGCGCCTCTTCCCTGGGGCTGAATCAGGCCCTGCTGCAAAACTCCAGGCTTCCCAGGGTTGGG
GAGGCTGTGGGACCAAGGTCCATGTTGGTCCTTCCACTGGGTGCAGCAGGAGCTGGGTCCCGAGAGCCTGGCAGGTGAAACTCTGCAGGC
CTTCCGCCTGATTATTATTTATTCACTCCTTTCCTCACCCCAAGTGCCCTGCTCTCCAGGTGCCTAGAGTATCCTAACTCTTAGGACCAG
GGATTGTCTTGCACCAAGTATGCCTACCCCTGGCCAGTCTGAGGTCTCCTAGCCATAGAACTGACTCCTGGAAGCCTGGAGAGAAGGTGG
TGACACCCATGGGTTCTCAACTGTAAGGAAAAAAGACACCAGACTTTTGTTCCCTAGTGGGGGAAAGCCCTTAGTCTTGTACAGGAGCAG
CTTGCTCCCAAGTCCTTTTGGAAGCTGGCAGAGCTATATTCCTGACAGCCCTGACTGCCAGGTAGAGCAAAAGACATTGGTGGGGGTATG
TGAAGCAAAAGGGGCAGGTGCACACACCTCCACAGTGACCTCTGTGCACACGGTTACCACCAACTGGCTGGCCCTCCTCCTCTTCCCTGG
CCCATTGATCATCCCTTCTCACAGAGGGTCATCATTATTTCCAAATATTGTTTGTCTGATGACTTCCTCTTCCCAGTGCAATTTTTCCCT
TCCTATTTCAACCTCTGGTTCCTGGGATGAGCCATACCCTGGAACTGGCCCACCCACTGTGTCTTCCACGTAAGGGAGACCTTTGCAAAG
GGCATCCAAATGGGTAGGCAGGTGACAGCCGCCGTATTTATTTTGCATAATATTTTAATTTGTATATTTTTGTGATTTATTTTGGCGTTA
TGAGTTTGACTCTCGGGGAGTTTTGTTGTTATGACTCTTGTGTCTTTTGTCACAAAACAATGATATTTGCTAAACGATATATGGAATTTA

>15326_15326_2_CDKAL1-CNNM4_CDKAL1_chr6_20548923_ENST00000378610_CNNM4_chr2_97427351_ENST00000377075_length(amino acids)=632AA_BP=60
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSIKLQLMALDPMELRIVQNCGTEKERRYARKIE
PIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGANTILLTKFFMLLTFPLSFPISKL
LDFFLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLQDCFMIRSDAILDFNTMSEIMESGYTRIPVFED
EQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEI
IKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHRFLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEH
NKYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTSVPSDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSS
NQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHKASHEN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CDKAL1-CNNM4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CDKAL1-CNNM4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CDKAL1-CNNM4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source