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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDKAL1-E2F3 (FusionGDB2 ID:15329)

Fusion Gene Summary for CDKAL1-E2F3

check button Fusion gene summary
Fusion gene informationFusion gene name: CDKAL1-E2F3
Fusion gene ID: 15329
HgeneTgene
Gene symbol

CDKAL1

E2F3

Gene ID

54901

1871

Gene nameCDK5 regulatory subunit associated protein 1 like 1E2F transcription factor 3
Synonyms-E2F-3
Cytomap

6p22.3

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionthreonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferasetranscription factor E2F3
Modification date2020032220200322
UniProtAcc.

O00716

Ensembl transtripts involved in fusion geneENST00000274695, ENST00000378610, 
ENST00000378624, ENST00000476517, 
ENST00000346618, ENST00000535432, 
Fusion gene scores* DoF score37 X 20 X 14=103604 X 5 X 5=100
# samples 396
** MAII scorelog2(39/10360*10)=-4.73140606882431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDKAL1 [Title/Abstract] AND E2F3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDKAL1(20548936)-E2F3(20480077), # samples:2
E2F3(20404063)-CDKAL1(20846306), # samples:1
E2F3(20404063)-CDKAL1(20546577), # samples:1
E2F3(20404063)-CDKAL1(20955650), # samples:1
Anticipated loss of major functional domain due to fusion event.CDKAL1-E2F3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CDKAL1-E2F3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
CDKAL1-E2F3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
E2F3-CDKAL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
E2F3-CDKAL1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
E2F3-CDKAL1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneE2F3

GO:0000082

G1/S transition of mitotic cell cycle

17062573

TgeneE2F3

GO:0006606

protein import into nucleus

17062573

TgeneE2F3

GO:0045944

positive regulation of transcription by RNA polymerase II

7739537


check buttonFusion gene breakpoints across CDKAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across E2F3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A6FHCDKAL1chr6

20739846

+E2F3chr6

20488343

+
ChimerDB4LUADTCGA-44-6778-01ACDKAL1chr6

20548936

+E2F3chr6

20480077

+
ChimerDB4LUSCTCGA-66-2757CDKAL1chr6

20649608

+E2F3chr6

20480076

+
ChimerDB4OVTCGA-61-2008-02ACDKAL1chr6

20548936

+E2F3chr6

20480077

+


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Fusion Gene ORF analysis for CDKAL1-E2F3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000274695ENST00000346618CDKAL1chr6

20548936

+E2F3chr6

20480077

+
Frame-shiftENST00000274695ENST00000346618CDKAL1chr6

20649608

+E2F3chr6

20480076

+
Frame-shiftENST00000274695ENST00000535432CDKAL1chr6

20548936

+E2F3chr6

20480077

+
Frame-shiftENST00000274695ENST00000535432CDKAL1chr6

20649608

+E2F3chr6

20480076

+
Frame-shiftENST00000378610ENST00000346618CDKAL1chr6

20548936

+E2F3chr6

20480077

+
Frame-shiftENST00000378610ENST00000346618CDKAL1chr6

20649608

+E2F3chr6

20480076

+
Frame-shiftENST00000378610ENST00000535432CDKAL1chr6

20548936

+E2F3chr6

20480077

+
Frame-shiftENST00000378610ENST00000535432CDKAL1chr6

20649608

+E2F3chr6

20480076

+
Frame-shiftENST00000378624ENST00000346618CDKAL1chr6

20649608

+E2F3chr6

20480076

+
Frame-shiftENST00000378624ENST00000535432CDKAL1chr6

20649608

+E2F3chr6

20480076

+
In-frameENST00000274695ENST00000346618CDKAL1chr6

20739846

+E2F3chr6

20488343

+
In-frameENST00000274695ENST00000535432CDKAL1chr6

20739846

+E2F3chr6

20488343

+
In-frameENST00000378610ENST00000346618CDKAL1chr6

20739846

+E2F3chr6

20488343

+
In-frameENST00000378610ENST00000535432CDKAL1chr6

20739846

+E2F3chr6

20488343

+
In-frameENST00000378624ENST00000346618CDKAL1chr6

20739846

+E2F3chr6

20488343

+
In-frameENST00000378624ENST00000535432CDKAL1chr6

20739846

+E2F3chr6

20488343

+
intron-3CDSENST00000378624ENST00000346618CDKAL1chr6

20548936

+E2F3chr6

20480077

+
intron-3CDSENST00000378624ENST00000535432CDKAL1chr6

20548936

+E2F3chr6

20480077

+
intron-3CDSENST00000476517ENST00000346618CDKAL1chr6

20739846

+E2F3chr6

20488343

+
intron-3CDSENST00000476517ENST00000346618CDKAL1chr6

20548936

+E2F3chr6

20480077

+
intron-3CDSENST00000476517ENST00000346618CDKAL1chr6

20649608

+E2F3chr6

20480076

+
intron-3CDSENST00000476517ENST00000535432CDKAL1chr6

20739846

+E2F3chr6

20488343

+
intron-3CDSENST00000476517ENST00000535432CDKAL1chr6

20548936

+E2F3chr6

20480077

+
intron-3CDSENST00000476517ENST00000535432CDKAL1chr6

20649608

+E2F3chr6

20480076

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274695CDKAL1chr620739846+ENST00000346618E2F3chr620488343+43146351671033288
ENST00000274695CDKAL1chr620739846+ENST00000535432E2F3chr620488343+41626351671033288
ENST00000378624CDKAL1chr620739846+ENST00000346618E2F3chr620488343+4201522264920218
ENST00000378624CDKAL1chr620739846+ENST00000535432E2F3chr620488343+4049522264920218
ENST00000378610CDKAL1chr620739846+ENST00000346618E2F3chr620488343+415747810876288
ENST00000378610CDKAL1chr620739846+ENST00000535432E2F3chr620488343+400547810876288

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274695ENST00000346618CDKAL1chr620739846+E2F3chr620488343+0.0004627020.99953735
ENST00000274695ENST00000535432CDKAL1chr620739846+E2F3chr620488343+0.0004661890.9995338
ENST00000378624ENST00000346618CDKAL1chr620739846+E2F3chr620488343+0.0005978810.99940217
ENST00000378624ENST00000535432CDKAL1chr620739846+E2F3chr620488343+0.0005110250.99948895
ENST00000378610ENST00000346618CDKAL1chr620739846+E2F3chr620488343+0.0004576410.99954236
ENST00000378610ENST00000535432CDKAL1chr620739846+E2F3chr620488343+0.0004624260.9995376

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Fusion Genomic Features for CDKAL1-E2F3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDKAL1chr620739846+E2F3chr620488343+0.158325610.8416743
CDKAL1chr620548936+E2F3chr620480076+0.020973760.9790262
CDKAL1chr620649608+E2F3chr620480076+3.03E-081
CDKAL1chr620739846+E2F3chr620488343+0.158325610.8416743
CDKAL1chr620548936+E2F3chr620480076+0.020973760.9790262
CDKAL1chr620649608+E2F3chr620480076+3.03E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDKAL1-E2F3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:20548936/chr6:20480077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.E2F3

O00716

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). {ECO:0000250|UniProtKB:O35261}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneE2F3chr6:20739846chr6:20488343ENST0000053543247209_245202335.0MotifNote=DEF box
TgeneE2F3chr6:20739846chr6:20488343ENST0000034661847391_465333466.0RegionTransactivation
TgeneE2F3chr6:20739846chr6:20488343ENST0000034661847432_449333466.0RegionRetinoblastoma protein binding
TgeneE2F3chr6:20739846chr6:20488343ENST0000053543247204_225202335.0RegionNote=Leucine-zipper
TgeneE2F3chr6:20739846chr6:20488343ENST0000053543247246_337202335.0RegionDimerization
TgeneE2F3chr6:20739846chr6:20488343ENST0000053543247391_465202335.0RegionTransactivation
TgeneE2F3chr6:20739846chr6:20488343ENST0000053543247432_449202335.0RegionRetinoblastoma protein binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000274695+616200_431156580.0DomainRadical SAM core
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000274695+616431_493156580.0DomainTRAM
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000274695+61664_172156580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000378610+414200_431156580.0DomainRadical SAM core
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000378610+414431_493156580.0DomainTRAM
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000378610+41464_172156580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000378624+514200_43186489.0DomainRadical SAM core
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000378624+514431_49386489.0DomainTRAM
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000378624+51464_17286489.0DomainMTTase N-terminal
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000274695+616556_578156580.0TransmembraneHelical
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000378610+414556_578156580.0TransmembraneHelical
HgeneCDKAL1chr6:20739846chr6:20488343ENST00000378624+514556_57886489.0TransmembraneHelical
TgeneE2F3chr6:20739846chr6:20488343ENST0000034661847120_129333466.0Compositional biasNote=Poly-Gly
TgeneE2F3chr6:20739846chr6:20488343ENST000003466184726_31333466.0Compositional biasNote=Poly-Ala
TgeneE2F3chr6:20739846chr6:20488343ENST000003466184745_53333466.0Compositional biasNote=Poly-Ala
TgeneE2F3chr6:20739846chr6:20488343ENST0000053543247120_129202335.0Compositional biasNote=Poly-Gly
TgeneE2F3chr6:20739846chr6:20488343ENST000005354324726_31202335.0Compositional biasNote=Poly-Ala
TgeneE2F3chr6:20739846chr6:20488343ENST000005354324745_53202335.0Compositional biasNote=Poly-Ala
TgeneE2F3chr6:20739846chr6:20488343ENST0000034661847155_245333466.0DNA bindingOntology_term=ECO:0000255
TgeneE2F3chr6:20739846chr6:20488343ENST0000053543247155_245202335.0DNA bindingOntology_term=ECO:0000255
TgeneE2F3chr6:20739846chr6:20488343ENST0000034661847209_245333466.0MotifNote=DEF box
TgeneE2F3chr6:20739846chr6:20488343ENST0000034661847101_153333466.0RegionCyclin A/CDK2 binding
TgeneE2F3chr6:20739846chr6:20488343ENST0000034661847204_225333466.0RegionNote=Leucine-zipper
TgeneE2F3chr6:20739846chr6:20488343ENST0000034661847246_337333466.0RegionDimerization
TgeneE2F3chr6:20739846chr6:20488343ENST0000053543247101_153202335.0RegionCyclin A/CDK2 binding


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Fusion Gene Sequence for CDKAL1-E2F3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15329_15329_1_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000274695_E2F3_chr6_20488343_ENST00000346618_length(transcript)=4314nt_BP=635nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAA
AAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCA
TTGGGAGCCTACAAATACATTTGGCAAGTACCCAAGGGCCCATTGAGGTTTACTTATGTCCAGAAGAGACTGAAACACACAGTCCAATGA
AAACAAACAACCAAGACCACAATGGGAATATCCCTAAACCCGCTTCCAAAGACTTGGCTTCAACCAACTCAGGACATAGCGATTGCTCAG
TTTCTATGGGAAACCTTTCTCCTCTGGCCTCCCCAGCCAACCTCTTACAGCAGACTGAGGACCAAATTCCTTCCAACCTAGAAGGACCGT
TTGTGAACTTACTGCCTCCCCTGCTGCAAGAGGACTATCTCCTGAGCCTCGGGGAGGAGGAAGGCATCAGCGATCTCTTCGATGCTTACG
ATTTGGAAAAGCTCCCACTGGTGGAAGACTTCATGTGTAGTTGATTATGCTTCGTGTGAACTCTCCTTAAAAACCGATATTTTTTTATCA
TGGAACCAGAACATCTGTCATGCAGTGTTGTCCCTTCCTACCTTCTTCCTCCAAGAGAGTATCATGAAGTAAACTACAAACTTCAGAAGA
AAGCTGACATTTTAATGAATTTTTTAAAAAATTAATAAACAAATTGTCTAAACGCACAGTTGCAGGCTCCCTTGGGAAAGCCCTGCTTTG
CTCCAGGCTCCAAGATCTCCTGGCTAAGTCAGCAAGTGAGAAAATGTGCAATCAGGTGTCTCTCACCCCGAATTGTCCTTCCTCCTTCCT
CCCCGGATTGGCTTGCTGTGCCTGACGGATGGGCTGTAGAATGGGGTCTGGCCACCTGGCCTGCTGGGAAACAGCAATCTTCCTTAATAG
CATTTCAAGCCGTGCCTTCTCCGCAGAATGCATGTCTTTGAGGTCTGCTAATATGGAATGGAACTGCAGCAAATGCAAACTTGAAGTCAT
GCAAAAGTATGAAATGGATTTCTTCAGCTCTTCTTAGGAATATTTAAATTACTGTCATAATTCAGTTTAAGCTATGAACTGTGTGTCCCA
GTAGGAGGTCAAGAAAACCTCCACAGCCTTCTGGATGAAGAACCTGTTTTCAAATATACTTGTTGCAGATACAGAAGACTAGTAGAGTTC
TGCCACTCTAAGCTGTTGTGGATTTTCCTGTCTCCATGAACCACTCCCATTCCCCCGTCCCCAATGTGTTTGTGAGTTTCCAGTTGATTT
GTAGCAAATGCCTACTTAGTTCTTTGTGGATTGTTCTAGACTTTTAATTTTTTTAGCTGCCATTTAAGCATTCCTGTGGCACCCATCACC
ATTTCAATTTAATTGTTTACTTTGAAGCGGTTTTTGCAAATTCATATTACTTAAGCAGAGGGAGAGAACCTCTACTGATCAGAGCATCTA
AACCTGTGTGATCTAAGGTTTATCAGCCTCTGCAAGGAGCTTTGTCCCATCGTGCTTCCATTCCCAGGAGGGGGAGCTTGGAGCGAGTCA
GTCCTGGGGCTTGCTGACATGGGTGGCCCATTGGAAAGGAGAACCAGGTCAGATGATGTAACAGCCCCAAGGAGCAGCAGGCATGGGTCC
CTCCATCCTTGGGCTTCCCGGGCCCCTGTGACAGGGGAAAGGGCTCTCTTACACCGCACTCAGGGAGACCACTTCTCAGGATGGGGTCAG
ATGGAGAGACCTCTAGGGAGAAAGACATCCCCATTGTGTGAGTGGCATTTCCTTAAGCTGGCAGGAACAGGGAGCAGCCCTGTGTCGGGG
GCTGGAATAGTTCTGGCCAGACCCCGTTCCCCTTCCTCTATGAAGGAATAAGTTGGACCAAGGGAAGTCGGGGACGTAAAAAATGAAGCA
AAACAATGCCAGGGTGTCTCCCGCTTTACTCTTCAGGAATGGTGTCCCAAGTTGGAGGCTTTGTGTCAGCTGCAAATCCTACCAGTTATG
TCCAAGAATGGCTTTCCCTCGGGCAGGTGGCAGCGGCCATCTCCCACTGGGAATATGGCGTAGTATCTCCGGTCCATTCCTTGGATGCTA
AGGACTGCGGGAATGAGGGAGTCAGATAAAGAACAAACCTCGAAACGAACAGTTAAATTGAAATGCTATGTGCCTGACCCAATGGTAGGC
ACATAGTAGGCACTCAACTCATATGTTTAATTGAATTGAAAATATCCCTTAGGAAAAAAAAAAAACACACAAAAAACCACAAGAGCCCCA
GCCAGTTTACTCCAGGTAGATTTCCACAATATGCAAAGTGGTGGTGGGGTCAAGACAGATGACACCAGCACTTTAAACTCTTTGTGTGGG
TATGCGTGGGTGTATGTTTGGGAAGAAAAACAAAGGTGCAGACTATCTTCCTTTTTTTCTTCTTCAGCCTCCATCCCTGGCCTCCTCCCC
TCACACACACTGGACTTGGTACAAAATGTCGGTGTGGTCCTAGATGAAGCATTGGGGTGGGGGAGGGAGAGGGAGCTTTGTGTTAAGTGC
CTACTGGAAATGCACTGTGGGGTTTTTTCCTGTATGGGAAACCATTTATGCCAAGCTTTTCCCCATTTCCCATATTTATCTCATCTGGTT
AGCTGCCTCTGCTTCCAGCTTTGTGTAATTCTCTTTGCCAGCTGCACAAAGCTGATTTTTTCCAAAGTCTAAAGACTGAGCTCACCTGGC
TAGATTGTTGTGTGTTTTGTTGAATTTTTTCATAATGTAATGCCGTATTTATTGTTTTTAAAATGAAAGGAATACTAATAAGTCTTAAAA
GTTCCTTCATGCATAAGATTTTTTTCCAGTTACTGGGTTTAACTGGTGTACATTAATTAGATGTCCATACTGTATTTTGTTTGCATTAAG
TAATTTTCTTTTTGACTTAGTATCCGGCACACAAAGTGGGTTAGTACTACAGTATTTGCGTTACTTTAAGTACTAAGTATGCAGGTTTCC
TGGTACCATTGAGTTGCTGCTATTAAAGCTCACACACGAAATGGCTAAAAGTTACAAGTGTGCAAATTATGACTGCGTGAGCCTTAGAAA
ATAAAATGTATAAAGGGCAACACATGAGCTGTCAAACAGTGTTAGGAGTGTGTTTATATGTACAGAGTTGTGCATAGCAATCGTTTTATT
TAAGTTGATATGTAGTCTACTCACATTTTCATTATTTAGCAATTTTGTACAAAAATAGCAATTAATTTGTAAACACTGCCAGAATACTTT
CTAGCTGCTTTGTAATTTTTTAAGAGTGTTATTTTGTTTTTGTTTTTCTGTTCTTTGTTGTGGCTCTTGTTTTCATTTTTGTTGTACGTG
TAGATCTGTAAATAAAATTGCAGTATTTAAAGCTTAAGCTTTCAGGAAAAAGAAAATAAGAATTCAGTGTGTGCATGACAACTCGTGTGT
ATGAGAAGGAGGGATATGAAGGAAGATGGCTTGCAGAGTAAGTCGGGTGGCAATTGTCAGGGTGTGGGAATTTCTTTTCCTACGGGGTAC
GTGATTTTGTAAAAAGGAAGTATTTCTCCCAAAATTGGGAGTAGGCAAACTACTAATCAGTTTAGCTTTGTGTTGTATGCTAGTTTAAAA
AAGAAAATATGTAATATAATGTAAAAAAAAACAAAAAAAAGCTTTTATGATGGATTTTGTAAATAGATTTGTTACAGGGTGACCTGTTCT

>15329_15329_1_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000274695_E2F3_chr6_20488343_ENST00000346618_length(amino acids)=288AA_BP=156
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGSLQIHLASTQGPIEVYLCPEETET
HSPMKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEGPFVNLLPPLLQEDYLLSLGEEEGISDL

--------------------------------------------------------------
>15329_15329_2_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000274695_E2F3_chr6_20488343_ENST00000535432_length(transcript)=4162nt_BP=635nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAA
AAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCA
TTGGGAGCCTACAAATACATTTGGCAAGTACCCAAGGGCCCATTGAGGTTTACTTATGTCCAGAAGAGACTGAAACACACAGTCCAATGA
AAACAAACAACCAAGACCACAATGGGAATATCCCTAAACCCGCTTCCAAAGACTTGGCTTCAACCAACTCAGGACATAGCGATTGCTCAG
TTTCTATGGGAAACCTTTCTCCTCTGGCCTCCCCAGCCAACCTCTTACAGCAGACTGAGGACCAAATTCCTTCCAACCTAGAAGGACCGT
TTGTGAACTTACTGCCTCCCCTGCTGCAAGAGGACTATCTCCTGAGCCTCGGGGAGGAGGAAGGCATCAGCGATCTCTTCGATGCTTACG
ATTTGGAAAAGCTCCCACTGGTGGAAGACTTCATGTGTAGTTGATTATGCTTCGTGTGAACTCTCCTTAAAAACCGATATTTTTTTATCA
TGGAACCAGAACATCTGTCATGCAGTGTTGTCCCTTCCTACCTTCTTCCTCCAAGAGAGTATCATGAAGTAAACTACAAACTTCAGAAGA
AAGCTGACATTTTAATGAATTTTTTAAAAAATTAATAAACAAATTGTCTAAACGCACAGTTGCAGGCTCCCTTGGGAAAGCCCTGCTTTG
CTCCAGGCTCCAAGATCTCCTGGCTAAGTCAGCAAGTGAGAAAATGTGCAATCAGGTGTCTCTCACCCCGAATTGTCCTTCCTCCTTCCT
CCCCGGATTGGCTTGCTGTGCCTGACGGATGGGCTGTAGAATGGGGTCTGGCCACCTGGCCTGCTGGGAAACAGCAATCTTCCTTAATAG
CATTTCAAGCCGTGCCTTCTCCGCAGAATGCATGTCTTTGAGGTCTGCTAATATGGAATGGAACTGCAGCAAATGCAAACTTGAAGTCAT
GCAAAAGTATGAAATGGATTTCTTCAGCTCTTCTTAGGAATATTTAAATTACTGTCATAATTCAGTTTAAGCTATGAACTGTGTGTCCCA
GTAGGAGGTCAAGAAAACCTCCACAGCCTTCTGGATGAAGAACCTGTTTTCAAATATACTTGTTGCAGATACAGAAGACTAGTAGAGTTC
TGCCACTCTAAGCTGTTGTGGATTTTCCTGTCTCCATGAACCACTCCCATTCCCCCGTCCCCAATGTGTTTGTGAGTTTCCAGTTGATTT
GTAGCAAATGCCTACTTAGTTCTTTGTGGATTGTTCTAGACTTTTAATTTTTTTAGCTGCCATTTAAGCATTCCTGTGGCACCCATCACC
ATTTCAATTTAATTGTTTACTTTGAAGCGGTTTTTGCAAATTCATATTACTTAAGCAGAGGGAGAGAACCTCTACTGATCAGAGCATCTA
AACCTGTGTGATCTAAGGTTTATCAGCCTCTGCAAGGAGCTTTGTCCCATCGTGCTTCCATTCCCAGGAGGGGGAGCTTGGAGCGAGTCA
GTCCTGGGGCTTGCTGACATGGGTGGCCCATTGGAAAGGAGAACCAGGTCAGATGATGTAACAGCCCCAAGGAGCAGCAGGCATGGGTCC
CTCCATCCTTGGGCTTCCCGGGCCCCTGTGACAGGGGAAAGGGCTCTCTTACACCGCACTCAGGGAGACCACTTCTCAGGATGGGGTCAG
ATGGAGAGACCTCTAGGGAGAAAGACATCCCCATTGTGTGAGTGGCATTTCCTTAAGCTGGCAGGAACAGGGAGCAGCCCTGTGTCGGGG
GCTGGAATAGTTCTGGCCAGACCCCGTTCCCCTTCCTCTATGAAGGAATAAGTTGGACCAAGGGAAGTCGGGGACGTAAAAAATGAAGCA
AAACAATGCCAGGGTGTCTCCCGCTTTACTCTTCAGGAATGGTGTCCCAAGTTGGAGGCTTTGTGTCAGCTGCAAATCCTACCAGTTATG
TCCAAGAATGGCTTTCCCTCGGGCAGGTGGCAGCGGCCATCTCCCACTGGGAATATGGCGTAGTATCTCCGGTCCATTCCTTGGATGCTA
AGGACTGCGGGAATGAGGGAGTCAGATAAAGAACAAACCTCGAAACGAACAGTTAAATTGAAATGCTATGTGCCTGACCCAATGGTAGGC
ACATAGTAGGCACTCAACTCATATGTTTAATTGAATTGAAAATATCCCTTAGGAAAAAAAAAAAACACACAAAAAACCACAAGAGCCCCA
GCCAGTTTACTCCAGGTAGATTTCCACAATATGCAAAGTGGTGGTGGGGTCAAGACAGATGACACCAGCACTTTAAACTCTTTGTGTGGG
TATGCGTGGGTGTATGTTTGGGAAGAAAAACAAAGGTGCAGACTATCTTCCTTTTTTTCTTCTTCAGCCTCCATCCCTGGCCTCCTCCCC
TCACACACACTGGACTTGGTACAAAATGTCGGTGTGGTCCTAGATGAAGCATTGGGGTGGGGGAGGGAGAGGGAGCTTTGTGTTAAGTGC
CTACTGGAAATGCACTGTGGGGTTTTTTCCTGTATGGGAAACCATTTATGCCAAGCTTTTCCCCATTTCCCATATTTATCTCATCTGGTT
AGCTGCCTCTGCTTCCAGCTTTGTGTAATTCTCTTTGCCAGCTGCACAAAGCTGATTTTTTCCAAAGTCTAAAGACTGAGCTCACCTGGC
TAGATTGTTGTGTGTTTTGTTGAATTTTTTCATAATGTAATGCCGTATTTATTGTTTTTAAAATGAAAGGAATACTAATAAGTCTTAAAA
GTTCCTTCATGCATAAGATTTTTTTCCAGTTACTGGGTTTAACTGGTGTACATTAATTAGATGTCCATACTGTATTTTGTTTGCATTAAG
TAATTTTCTTTTTGACTTAGTATCCGGCACACAAAGTGGGTTAGTACTACAGTATTTGCGTTACTTTAAGTACTAAGTATGCAGGTTTCC
TGGTACCATTGAGTTGCTGCTATTAAAGCTCACACACGAAATGGCTAAAAGTTACAAGTGTGCAAATTATGACTGCGTGAGCCTTAGAAA
ATAAAATGTATAAAGGGCAACACATGAGCTGTCAAACAGTGTTAGGAGTGTGTTTATATGTACAGAGTTGTGCATAGCAATCGTTTTATT
TAAGTTGATATGTAGTCTACTCACATTTTCATTATTTAGCAATTTTGTACAAAAATAGCAATTAATTTGTAAACACTGCCAGAATACTTT
CTAGCTGCTTTGTAATTTTTTAAGAGTGTTATTTTGTTTTTGTTTTTCTGTTCTTTGTTGTGGCTCTTGTTTTCATTTTTGTTGTACGTG
TAGATCTGTAAATAAAATTGCAGTATTTAAAGCTTAAGCTTTCAGGAAAAAGAAAATAAGAATTCAGTGTGTGCATGACAACTCGTGTGT
ATGAGAAGGAGGGATATGAAGGAAGATGGCTTGCAGAGTAAGTCGGGTGGCAATTGTCAGGGTGTGGGAATTTCTTTTCCTACGGGGTAC
GTGATTTTGTAAAAAGGAAGTATTTCTCCCAAAATTGGGAGTAGGCAAACTACTAATCAGTTTAGCTTTGTGTTGTATGCTAGTTTAAAA

>15329_15329_2_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000274695_E2F3_chr6_20488343_ENST00000535432_length(amino acids)=288AA_BP=156
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGSLQIHLASTQGPIEVYLCPEETET
HSPMKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEGPFVNLLPPLLQEDYLLSLGEEEGISDL

--------------------------------------------------------------
>15329_15329_3_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000378610_E2F3_chr6_20488343_ENST00000346618_length(transcript)=4157nt_BP=478nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGA
CCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGA
CTACCTTAAGGGACTGAGTATCATTGGGAGCCTACAAATACATTTGGCAAGTACCCAAGGGCCCATTGAGGTTTACTTATGTCCAGAAGA
GACTGAAACACACAGTCCAATGAAAACAAACAACCAAGACCACAATGGGAATATCCCTAAACCCGCTTCCAAAGACTTGGCTTCAACCAA
CTCAGGACATAGCGATTGCTCAGTTTCTATGGGAAACCTTTCTCCTCTGGCCTCCCCAGCCAACCTCTTACAGCAGACTGAGGACCAAAT
TCCTTCCAACCTAGAAGGACCGTTTGTGAACTTACTGCCTCCCCTGCTGCAAGAGGACTATCTCCTGAGCCTCGGGGAGGAGGAAGGCAT
CAGCGATCTCTTCGATGCTTACGATTTGGAAAAGCTCCCACTGGTGGAAGACTTCATGTGTAGTTGATTATGCTTCGTGTGAACTCTCCT
TAAAAACCGATATTTTTTTATCATGGAACCAGAACATCTGTCATGCAGTGTTGTCCCTTCCTACCTTCTTCCTCCAAGAGAGTATCATGA
AGTAAACTACAAACTTCAGAAGAAAGCTGACATTTTAATGAATTTTTTAAAAAATTAATAAACAAATTGTCTAAACGCACAGTTGCAGGC
TCCCTTGGGAAAGCCCTGCTTTGCTCCAGGCTCCAAGATCTCCTGGCTAAGTCAGCAAGTGAGAAAATGTGCAATCAGGTGTCTCTCACC
CCGAATTGTCCTTCCTCCTTCCTCCCCGGATTGGCTTGCTGTGCCTGACGGATGGGCTGTAGAATGGGGTCTGGCCACCTGGCCTGCTGG
GAAACAGCAATCTTCCTTAATAGCATTTCAAGCCGTGCCTTCTCCGCAGAATGCATGTCTTTGAGGTCTGCTAATATGGAATGGAACTGC
AGCAAATGCAAACTTGAAGTCATGCAAAAGTATGAAATGGATTTCTTCAGCTCTTCTTAGGAATATTTAAATTACTGTCATAATTCAGTT
TAAGCTATGAACTGTGTGTCCCAGTAGGAGGTCAAGAAAACCTCCACAGCCTTCTGGATGAAGAACCTGTTTTCAAATATACTTGTTGCA
GATACAGAAGACTAGTAGAGTTCTGCCACTCTAAGCTGTTGTGGATTTTCCTGTCTCCATGAACCACTCCCATTCCCCCGTCCCCAATGT
GTTTGTGAGTTTCCAGTTGATTTGTAGCAAATGCCTACTTAGTTCTTTGTGGATTGTTCTAGACTTTTAATTTTTTTAGCTGCCATTTAA
GCATTCCTGTGGCACCCATCACCATTTCAATTTAATTGTTTACTTTGAAGCGGTTTTTGCAAATTCATATTACTTAAGCAGAGGGAGAGA
ACCTCTACTGATCAGAGCATCTAAACCTGTGTGATCTAAGGTTTATCAGCCTCTGCAAGGAGCTTTGTCCCATCGTGCTTCCATTCCCAG
GAGGGGGAGCTTGGAGCGAGTCAGTCCTGGGGCTTGCTGACATGGGTGGCCCATTGGAAAGGAGAACCAGGTCAGATGATGTAACAGCCC
CAAGGAGCAGCAGGCATGGGTCCCTCCATCCTTGGGCTTCCCGGGCCCCTGTGACAGGGGAAAGGGCTCTCTTACACCGCACTCAGGGAG
ACCACTTCTCAGGATGGGGTCAGATGGAGAGACCTCTAGGGAGAAAGACATCCCCATTGTGTGAGTGGCATTTCCTTAAGCTGGCAGGAA
CAGGGAGCAGCCCTGTGTCGGGGGCTGGAATAGTTCTGGCCAGACCCCGTTCCCCTTCCTCTATGAAGGAATAAGTTGGACCAAGGGAAG
TCGGGGACGTAAAAAATGAAGCAAAACAATGCCAGGGTGTCTCCCGCTTTACTCTTCAGGAATGGTGTCCCAAGTTGGAGGCTTTGTGTC
AGCTGCAAATCCTACCAGTTATGTCCAAGAATGGCTTTCCCTCGGGCAGGTGGCAGCGGCCATCTCCCACTGGGAATATGGCGTAGTATC
TCCGGTCCATTCCTTGGATGCTAAGGACTGCGGGAATGAGGGAGTCAGATAAAGAACAAACCTCGAAACGAACAGTTAAATTGAAATGCT
ATGTGCCTGACCCAATGGTAGGCACATAGTAGGCACTCAACTCATATGTTTAATTGAATTGAAAATATCCCTTAGGAAAAAAAAAAAACA
CACAAAAAACCACAAGAGCCCCAGCCAGTTTACTCCAGGTAGATTTCCACAATATGCAAAGTGGTGGTGGGGTCAAGACAGATGACACCA
GCACTTTAAACTCTTTGTGTGGGTATGCGTGGGTGTATGTTTGGGAAGAAAAACAAAGGTGCAGACTATCTTCCTTTTTTTCTTCTTCAG
CCTCCATCCCTGGCCTCCTCCCCTCACACACACTGGACTTGGTACAAAATGTCGGTGTGGTCCTAGATGAAGCATTGGGGTGGGGGAGGG
AGAGGGAGCTTTGTGTTAAGTGCCTACTGGAAATGCACTGTGGGGTTTTTTCCTGTATGGGAAACCATTTATGCCAAGCTTTTCCCCATT
TCCCATATTTATCTCATCTGGTTAGCTGCCTCTGCTTCCAGCTTTGTGTAATTCTCTTTGCCAGCTGCACAAAGCTGATTTTTTCCAAAG
TCTAAAGACTGAGCTCACCTGGCTAGATTGTTGTGTGTTTTGTTGAATTTTTTCATAATGTAATGCCGTATTTATTGTTTTTAAAATGAA
AGGAATACTAATAAGTCTTAAAAGTTCCTTCATGCATAAGATTTTTTTCCAGTTACTGGGTTTAACTGGTGTACATTAATTAGATGTCCA
TACTGTATTTTGTTTGCATTAAGTAATTTTCTTTTTGACTTAGTATCCGGCACACAAAGTGGGTTAGTACTACAGTATTTGCGTTACTTT
AAGTACTAAGTATGCAGGTTTCCTGGTACCATTGAGTTGCTGCTATTAAAGCTCACACACGAAATGGCTAAAAGTTACAAGTGTGCAAAT
TATGACTGCGTGAGCCTTAGAAAATAAAATGTATAAAGGGCAACACATGAGCTGTCAAACAGTGTTAGGAGTGTGTTTATATGTACAGAG
TTGTGCATAGCAATCGTTTTATTTAAGTTGATATGTAGTCTACTCACATTTTCATTATTTAGCAATTTTGTACAAAAATAGCAATTAATT
TGTAAACACTGCCAGAATACTTTCTAGCTGCTTTGTAATTTTTTAAGAGTGTTATTTTGTTTTTGTTTTTCTGTTCTTTGTTGTGGCTCT
TGTTTTCATTTTTGTTGTACGTGTAGATCTGTAAATAAAATTGCAGTATTTAAAGCTTAAGCTTTCAGGAAAAAGAAAATAAGAATTCAG
TGTGTGCATGACAACTCGTGTGTATGAGAAGGAGGGATATGAAGGAAGATGGCTTGCAGAGTAAGTCGGGTGGCAATTGTCAGGGTGTGG
GAATTTCTTTTCCTACGGGGTACGTGATTTTGTAAAAAGGAAGTATTTCTCCCAAAATTGGGAGTAGGCAAACTACTAATCAGTTTAGCT
TTGTGTTGTATGCTAGTTTAAAAAAGAAAATATGTAATATAATGTAAAAAAAAACAAAAAAAAGCTTTTATGATGGATTTTGTAAATAGA
TTTGTTACAGGGTGACCTGTTCTCTAGCTGTGATCTTACCACTTCAAATGGGTGTAATTTGAATAAATTTTGTATGGTAAAGGATCAATA

>15329_15329_3_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000378610_E2F3_chr6_20488343_ENST00000346618_length(amino acids)=288AA_BP=156
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGSLQIHLASTQGPIEVYLCPEETET
HSPMKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEGPFVNLLPPLLQEDYLLSLGEEEGISDL

--------------------------------------------------------------
>15329_15329_4_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000378610_E2F3_chr6_20488343_ENST00000535432_length(transcript)=4005nt_BP=478nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGA
CCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGA
CTACCTTAAGGGACTGAGTATCATTGGGAGCCTACAAATACATTTGGCAAGTACCCAAGGGCCCATTGAGGTTTACTTATGTCCAGAAGA
GACTGAAACACACAGTCCAATGAAAACAAACAACCAAGACCACAATGGGAATATCCCTAAACCCGCTTCCAAAGACTTGGCTTCAACCAA
CTCAGGACATAGCGATTGCTCAGTTTCTATGGGAAACCTTTCTCCTCTGGCCTCCCCAGCCAACCTCTTACAGCAGACTGAGGACCAAAT
TCCTTCCAACCTAGAAGGACCGTTTGTGAACTTACTGCCTCCCCTGCTGCAAGAGGACTATCTCCTGAGCCTCGGGGAGGAGGAAGGCAT
CAGCGATCTCTTCGATGCTTACGATTTGGAAAAGCTCCCACTGGTGGAAGACTTCATGTGTAGTTGATTATGCTTCGTGTGAACTCTCCT
TAAAAACCGATATTTTTTTATCATGGAACCAGAACATCTGTCATGCAGTGTTGTCCCTTCCTACCTTCTTCCTCCAAGAGAGTATCATGA
AGTAAACTACAAACTTCAGAAGAAAGCTGACATTTTAATGAATTTTTTAAAAAATTAATAAACAAATTGTCTAAACGCACAGTTGCAGGC
TCCCTTGGGAAAGCCCTGCTTTGCTCCAGGCTCCAAGATCTCCTGGCTAAGTCAGCAAGTGAGAAAATGTGCAATCAGGTGTCTCTCACC
CCGAATTGTCCTTCCTCCTTCCTCCCCGGATTGGCTTGCTGTGCCTGACGGATGGGCTGTAGAATGGGGTCTGGCCACCTGGCCTGCTGG
GAAACAGCAATCTTCCTTAATAGCATTTCAAGCCGTGCCTTCTCCGCAGAATGCATGTCTTTGAGGTCTGCTAATATGGAATGGAACTGC
AGCAAATGCAAACTTGAAGTCATGCAAAAGTATGAAATGGATTTCTTCAGCTCTTCTTAGGAATATTTAAATTACTGTCATAATTCAGTT
TAAGCTATGAACTGTGTGTCCCAGTAGGAGGTCAAGAAAACCTCCACAGCCTTCTGGATGAAGAACCTGTTTTCAAATATACTTGTTGCA
GATACAGAAGACTAGTAGAGTTCTGCCACTCTAAGCTGTTGTGGATTTTCCTGTCTCCATGAACCACTCCCATTCCCCCGTCCCCAATGT
GTTTGTGAGTTTCCAGTTGATTTGTAGCAAATGCCTACTTAGTTCTTTGTGGATTGTTCTAGACTTTTAATTTTTTTAGCTGCCATTTAA
GCATTCCTGTGGCACCCATCACCATTTCAATTTAATTGTTTACTTTGAAGCGGTTTTTGCAAATTCATATTACTTAAGCAGAGGGAGAGA
ACCTCTACTGATCAGAGCATCTAAACCTGTGTGATCTAAGGTTTATCAGCCTCTGCAAGGAGCTTTGTCCCATCGTGCTTCCATTCCCAG
GAGGGGGAGCTTGGAGCGAGTCAGTCCTGGGGCTTGCTGACATGGGTGGCCCATTGGAAAGGAGAACCAGGTCAGATGATGTAACAGCCC
CAAGGAGCAGCAGGCATGGGTCCCTCCATCCTTGGGCTTCCCGGGCCCCTGTGACAGGGGAAAGGGCTCTCTTACACCGCACTCAGGGAG
ACCACTTCTCAGGATGGGGTCAGATGGAGAGACCTCTAGGGAGAAAGACATCCCCATTGTGTGAGTGGCATTTCCTTAAGCTGGCAGGAA
CAGGGAGCAGCCCTGTGTCGGGGGCTGGAATAGTTCTGGCCAGACCCCGTTCCCCTTCCTCTATGAAGGAATAAGTTGGACCAAGGGAAG
TCGGGGACGTAAAAAATGAAGCAAAACAATGCCAGGGTGTCTCCCGCTTTACTCTTCAGGAATGGTGTCCCAAGTTGGAGGCTTTGTGTC
AGCTGCAAATCCTACCAGTTATGTCCAAGAATGGCTTTCCCTCGGGCAGGTGGCAGCGGCCATCTCCCACTGGGAATATGGCGTAGTATC
TCCGGTCCATTCCTTGGATGCTAAGGACTGCGGGAATGAGGGAGTCAGATAAAGAACAAACCTCGAAACGAACAGTTAAATTGAAATGCT
ATGTGCCTGACCCAATGGTAGGCACATAGTAGGCACTCAACTCATATGTTTAATTGAATTGAAAATATCCCTTAGGAAAAAAAAAAAACA
CACAAAAAACCACAAGAGCCCCAGCCAGTTTACTCCAGGTAGATTTCCACAATATGCAAAGTGGTGGTGGGGTCAAGACAGATGACACCA
GCACTTTAAACTCTTTGTGTGGGTATGCGTGGGTGTATGTTTGGGAAGAAAAACAAAGGTGCAGACTATCTTCCTTTTTTTCTTCTTCAG
CCTCCATCCCTGGCCTCCTCCCCTCACACACACTGGACTTGGTACAAAATGTCGGTGTGGTCCTAGATGAAGCATTGGGGTGGGGGAGGG
AGAGGGAGCTTTGTGTTAAGTGCCTACTGGAAATGCACTGTGGGGTTTTTTCCTGTATGGGAAACCATTTATGCCAAGCTTTTCCCCATT
TCCCATATTTATCTCATCTGGTTAGCTGCCTCTGCTTCCAGCTTTGTGTAATTCTCTTTGCCAGCTGCACAAAGCTGATTTTTTCCAAAG
TCTAAAGACTGAGCTCACCTGGCTAGATTGTTGTGTGTTTTGTTGAATTTTTTCATAATGTAATGCCGTATTTATTGTTTTTAAAATGAA
AGGAATACTAATAAGTCTTAAAAGTTCCTTCATGCATAAGATTTTTTTCCAGTTACTGGGTTTAACTGGTGTACATTAATTAGATGTCCA
TACTGTATTTTGTTTGCATTAAGTAATTTTCTTTTTGACTTAGTATCCGGCACACAAAGTGGGTTAGTACTACAGTATTTGCGTTACTTT
AAGTACTAAGTATGCAGGTTTCCTGGTACCATTGAGTTGCTGCTATTAAAGCTCACACACGAAATGGCTAAAAGTTACAAGTGTGCAAAT
TATGACTGCGTGAGCCTTAGAAAATAAAATGTATAAAGGGCAACACATGAGCTGTCAAACAGTGTTAGGAGTGTGTTTATATGTACAGAG
TTGTGCATAGCAATCGTTTTATTTAAGTTGATATGTAGTCTACTCACATTTTCATTATTTAGCAATTTTGTACAAAAATAGCAATTAATT
TGTAAACACTGCCAGAATACTTTCTAGCTGCTTTGTAATTTTTTAAGAGTGTTATTTTGTTTTTGTTTTTCTGTTCTTTGTTGTGGCTCT
TGTTTTCATTTTTGTTGTACGTGTAGATCTGTAAATAAAATTGCAGTATTTAAAGCTTAAGCTTTCAGGAAAAAGAAAATAAGAATTCAG
TGTGTGCATGACAACTCGTGTGTATGAGAAGGAGGGATATGAAGGAAGATGGCTTGCAGAGTAAGTCGGGTGGCAATTGTCAGGGTGTGG
GAATTTCTTTTCCTACGGGGTACGTGATTTTGTAAAAAGGAAGTATTTCTCCCAAAATTGGGAGTAGGCAAACTACTAATCAGTTTAGCT

>15329_15329_4_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000378610_E2F3_chr6_20488343_ENST00000535432_length(amino acids)=288AA_BP=156
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGSLQIHLASTQGPIEVYLCPEETET
HSPMKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEGPFVNLLPPLLQEDYLLSLGEEEGISDL

--------------------------------------------------------------
>15329_15329_5_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000378624_E2F3_chr6_20488343_ENST00000346618_length(transcript)=4201nt_BP=522nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGAAAATGCATCCGATGCAGAT
TTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAA
ATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCATTGGGAGCCTACAAATACATTTG
GCAAGTACCCAAGGGCCCATTGAGGTTTACTTATGTCCAGAAGAGACTGAAACACACAGTCCAATGAAAACAAACAACCAAGACCACAAT
GGGAATATCCCTAAACCCGCTTCCAAAGACTTGGCTTCAACCAACTCAGGACATAGCGATTGCTCAGTTTCTATGGGAAACCTTTCTCCT
CTGGCCTCCCCAGCCAACCTCTTACAGCAGACTGAGGACCAAATTCCTTCCAACCTAGAAGGACCGTTTGTGAACTTACTGCCTCCCCTG
CTGCAAGAGGACTATCTCCTGAGCCTCGGGGAGGAGGAAGGCATCAGCGATCTCTTCGATGCTTACGATTTGGAAAAGCTCCCACTGGTG
GAAGACTTCATGTGTAGTTGATTATGCTTCGTGTGAACTCTCCTTAAAAACCGATATTTTTTTATCATGGAACCAGAACATCTGTCATGC
AGTGTTGTCCCTTCCTACCTTCTTCCTCCAAGAGAGTATCATGAAGTAAACTACAAACTTCAGAAGAAAGCTGACATTTTAATGAATTTT
TTAAAAAATTAATAAACAAATTGTCTAAACGCACAGTTGCAGGCTCCCTTGGGAAAGCCCTGCTTTGCTCCAGGCTCCAAGATCTCCTGG
CTAAGTCAGCAAGTGAGAAAATGTGCAATCAGGTGTCTCTCACCCCGAATTGTCCTTCCTCCTTCCTCCCCGGATTGGCTTGCTGTGCCT
GACGGATGGGCTGTAGAATGGGGTCTGGCCACCTGGCCTGCTGGGAAACAGCAATCTTCCTTAATAGCATTTCAAGCCGTGCCTTCTCCG
CAGAATGCATGTCTTTGAGGTCTGCTAATATGGAATGGAACTGCAGCAAATGCAAACTTGAAGTCATGCAAAAGTATGAAATGGATTTCT
TCAGCTCTTCTTAGGAATATTTAAATTACTGTCATAATTCAGTTTAAGCTATGAACTGTGTGTCCCAGTAGGAGGTCAAGAAAACCTCCA
CAGCCTTCTGGATGAAGAACCTGTTTTCAAATATACTTGTTGCAGATACAGAAGACTAGTAGAGTTCTGCCACTCTAAGCTGTTGTGGAT
TTTCCTGTCTCCATGAACCACTCCCATTCCCCCGTCCCCAATGTGTTTGTGAGTTTCCAGTTGATTTGTAGCAAATGCCTACTTAGTTCT
TTGTGGATTGTTCTAGACTTTTAATTTTTTTAGCTGCCATTTAAGCATTCCTGTGGCACCCATCACCATTTCAATTTAATTGTTTACTTT
GAAGCGGTTTTTGCAAATTCATATTACTTAAGCAGAGGGAGAGAACCTCTACTGATCAGAGCATCTAAACCTGTGTGATCTAAGGTTTAT
CAGCCTCTGCAAGGAGCTTTGTCCCATCGTGCTTCCATTCCCAGGAGGGGGAGCTTGGAGCGAGTCAGTCCTGGGGCTTGCTGACATGGG
TGGCCCATTGGAAAGGAGAACCAGGTCAGATGATGTAACAGCCCCAAGGAGCAGCAGGCATGGGTCCCTCCATCCTTGGGCTTCCCGGGC
CCCTGTGACAGGGGAAAGGGCTCTCTTACACCGCACTCAGGGAGACCACTTCTCAGGATGGGGTCAGATGGAGAGACCTCTAGGGAGAAA
GACATCCCCATTGTGTGAGTGGCATTTCCTTAAGCTGGCAGGAACAGGGAGCAGCCCTGTGTCGGGGGCTGGAATAGTTCTGGCCAGACC
CCGTTCCCCTTCCTCTATGAAGGAATAAGTTGGACCAAGGGAAGTCGGGGACGTAAAAAATGAAGCAAAACAATGCCAGGGTGTCTCCCG
CTTTACTCTTCAGGAATGGTGTCCCAAGTTGGAGGCTTTGTGTCAGCTGCAAATCCTACCAGTTATGTCCAAGAATGGCTTTCCCTCGGG
CAGGTGGCAGCGGCCATCTCCCACTGGGAATATGGCGTAGTATCTCCGGTCCATTCCTTGGATGCTAAGGACTGCGGGAATGAGGGAGTC
AGATAAAGAACAAACCTCGAAACGAACAGTTAAATTGAAATGCTATGTGCCTGACCCAATGGTAGGCACATAGTAGGCACTCAACTCATA
TGTTTAATTGAATTGAAAATATCCCTTAGGAAAAAAAAAAAACACACAAAAAACCACAAGAGCCCCAGCCAGTTTACTCCAGGTAGATTT
CCACAATATGCAAAGTGGTGGTGGGGTCAAGACAGATGACACCAGCACTTTAAACTCTTTGTGTGGGTATGCGTGGGTGTATGTTTGGGA
AGAAAAACAAAGGTGCAGACTATCTTCCTTTTTTTCTTCTTCAGCCTCCATCCCTGGCCTCCTCCCCTCACACACACTGGACTTGGTACA
AAATGTCGGTGTGGTCCTAGATGAAGCATTGGGGTGGGGGAGGGAGAGGGAGCTTTGTGTTAAGTGCCTACTGGAAATGCACTGTGGGGT
TTTTTCCTGTATGGGAAACCATTTATGCCAAGCTTTTCCCCATTTCCCATATTTATCTCATCTGGTTAGCTGCCTCTGCTTCCAGCTTTG
TGTAATTCTCTTTGCCAGCTGCACAAAGCTGATTTTTTCCAAAGTCTAAAGACTGAGCTCACCTGGCTAGATTGTTGTGTGTTTTGTTGA
ATTTTTTCATAATGTAATGCCGTATTTATTGTTTTTAAAATGAAAGGAATACTAATAAGTCTTAAAAGTTCCTTCATGCATAAGATTTTT
TTCCAGTTACTGGGTTTAACTGGTGTACATTAATTAGATGTCCATACTGTATTTTGTTTGCATTAAGTAATTTTCTTTTTGACTTAGTAT
CCGGCACACAAAGTGGGTTAGTACTACAGTATTTGCGTTACTTTAAGTACTAAGTATGCAGGTTTCCTGGTACCATTGAGTTGCTGCTAT
TAAAGCTCACACACGAAATGGCTAAAAGTTACAAGTGTGCAAATTATGACTGCGTGAGCCTTAGAAAATAAAATGTATAAAGGGCAACAC
ATGAGCTGTCAAACAGTGTTAGGAGTGTGTTTATATGTACAGAGTTGTGCATAGCAATCGTTTTATTTAAGTTGATATGTAGTCTACTCA
CATTTTCATTATTTAGCAATTTTGTACAAAAATAGCAATTAATTTGTAAACACTGCCAGAATACTTTCTAGCTGCTTTGTAATTTTTTAA
GAGTGTTATTTTGTTTTTGTTTTTCTGTTCTTTGTTGTGGCTCTTGTTTTCATTTTTGTTGTACGTGTAGATCTGTAAATAAAATTGCAG
TATTTAAAGCTTAAGCTTTCAGGAAAAAGAAAATAAGAATTCAGTGTGTGCATGACAACTCGTGTGTATGAGAAGGAGGGATATGAAGGA
AGATGGCTTGCAGAGTAAGTCGGGTGGCAATTGTCAGGGTGTGGGAATTTCTTTTCCTACGGGGTACGTGATTTTGTAAAAAGGAAGTAT
TTCTCCCAAAATTGGGAGTAGGCAAACTACTAATCAGTTTAGCTTTGTGTTGTATGCTAGTTTAAAAAAGAAAATATGTAATATAATGTA
AAAAAAAACAAAAAAAAGCTTTTATGATGGATTTTGTAAATAGATTTGTTACAGGGTGACCTGTTCTCTAGCTGTGATCTTACCACTTCA

>15329_15329_5_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000378624_E2F3_chr6_20488343_ENST00000346618_length(amino acids)=218AA_BP=86
MLSRRYEGEIPKNICKRKKTVHQVTENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGSLQI
HLASTQGPIEVYLCPEETETHSPMKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEGPFVNLLP

--------------------------------------------------------------
>15329_15329_6_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000378624_E2F3_chr6_20488343_ENST00000535432_length(transcript)=4049nt_BP=522nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGAAAATGCATCCGATGCAGAT
TTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAA
ATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCATTGGGAGCCTACAAATACATTTG
GCAAGTACCCAAGGGCCCATTGAGGTTTACTTATGTCCAGAAGAGACTGAAACACACAGTCCAATGAAAACAAACAACCAAGACCACAAT
GGGAATATCCCTAAACCCGCTTCCAAAGACTTGGCTTCAACCAACTCAGGACATAGCGATTGCTCAGTTTCTATGGGAAACCTTTCTCCT
CTGGCCTCCCCAGCCAACCTCTTACAGCAGACTGAGGACCAAATTCCTTCCAACCTAGAAGGACCGTTTGTGAACTTACTGCCTCCCCTG
CTGCAAGAGGACTATCTCCTGAGCCTCGGGGAGGAGGAAGGCATCAGCGATCTCTTCGATGCTTACGATTTGGAAAAGCTCCCACTGGTG
GAAGACTTCATGTGTAGTTGATTATGCTTCGTGTGAACTCTCCTTAAAAACCGATATTTTTTTATCATGGAACCAGAACATCTGTCATGC
AGTGTTGTCCCTTCCTACCTTCTTCCTCCAAGAGAGTATCATGAAGTAAACTACAAACTTCAGAAGAAAGCTGACATTTTAATGAATTTT
TTAAAAAATTAATAAACAAATTGTCTAAACGCACAGTTGCAGGCTCCCTTGGGAAAGCCCTGCTTTGCTCCAGGCTCCAAGATCTCCTGG
CTAAGTCAGCAAGTGAGAAAATGTGCAATCAGGTGTCTCTCACCCCGAATTGTCCTTCCTCCTTCCTCCCCGGATTGGCTTGCTGTGCCT
GACGGATGGGCTGTAGAATGGGGTCTGGCCACCTGGCCTGCTGGGAAACAGCAATCTTCCTTAATAGCATTTCAAGCCGTGCCTTCTCCG
CAGAATGCATGTCTTTGAGGTCTGCTAATATGGAATGGAACTGCAGCAAATGCAAACTTGAAGTCATGCAAAAGTATGAAATGGATTTCT
TCAGCTCTTCTTAGGAATATTTAAATTACTGTCATAATTCAGTTTAAGCTATGAACTGTGTGTCCCAGTAGGAGGTCAAGAAAACCTCCA
CAGCCTTCTGGATGAAGAACCTGTTTTCAAATATACTTGTTGCAGATACAGAAGACTAGTAGAGTTCTGCCACTCTAAGCTGTTGTGGAT
TTTCCTGTCTCCATGAACCACTCCCATTCCCCCGTCCCCAATGTGTTTGTGAGTTTCCAGTTGATTTGTAGCAAATGCCTACTTAGTTCT
TTGTGGATTGTTCTAGACTTTTAATTTTTTTAGCTGCCATTTAAGCATTCCTGTGGCACCCATCACCATTTCAATTTAATTGTTTACTTT
GAAGCGGTTTTTGCAAATTCATATTACTTAAGCAGAGGGAGAGAACCTCTACTGATCAGAGCATCTAAACCTGTGTGATCTAAGGTTTAT
CAGCCTCTGCAAGGAGCTTTGTCCCATCGTGCTTCCATTCCCAGGAGGGGGAGCTTGGAGCGAGTCAGTCCTGGGGCTTGCTGACATGGG
TGGCCCATTGGAAAGGAGAACCAGGTCAGATGATGTAACAGCCCCAAGGAGCAGCAGGCATGGGTCCCTCCATCCTTGGGCTTCCCGGGC
CCCTGTGACAGGGGAAAGGGCTCTCTTACACCGCACTCAGGGAGACCACTTCTCAGGATGGGGTCAGATGGAGAGACCTCTAGGGAGAAA
GACATCCCCATTGTGTGAGTGGCATTTCCTTAAGCTGGCAGGAACAGGGAGCAGCCCTGTGTCGGGGGCTGGAATAGTTCTGGCCAGACC
CCGTTCCCCTTCCTCTATGAAGGAATAAGTTGGACCAAGGGAAGTCGGGGACGTAAAAAATGAAGCAAAACAATGCCAGGGTGTCTCCCG
CTTTACTCTTCAGGAATGGTGTCCCAAGTTGGAGGCTTTGTGTCAGCTGCAAATCCTACCAGTTATGTCCAAGAATGGCTTTCCCTCGGG
CAGGTGGCAGCGGCCATCTCCCACTGGGAATATGGCGTAGTATCTCCGGTCCATTCCTTGGATGCTAAGGACTGCGGGAATGAGGGAGTC
AGATAAAGAACAAACCTCGAAACGAACAGTTAAATTGAAATGCTATGTGCCTGACCCAATGGTAGGCACATAGTAGGCACTCAACTCATA
TGTTTAATTGAATTGAAAATATCCCTTAGGAAAAAAAAAAAACACACAAAAAACCACAAGAGCCCCAGCCAGTTTACTCCAGGTAGATTT
CCACAATATGCAAAGTGGTGGTGGGGTCAAGACAGATGACACCAGCACTTTAAACTCTTTGTGTGGGTATGCGTGGGTGTATGTTTGGGA
AGAAAAACAAAGGTGCAGACTATCTTCCTTTTTTTCTTCTTCAGCCTCCATCCCTGGCCTCCTCCCCTCACACACACTGGACTTGGTACA
AAATGTCGGTGTGGTCCTAGATGAAGCATTGGGGTGGGGGAGGGAGAGGGAGCTTTGTGTTAAGTGCCTACTGGAAATGCACTGTGGGGT
TTTTTCCTGTATGGGAAACCATTTATGCCAAGCTTTTCCCCATTTCCCATATTTATCTCATCTGGTTAGCTGCCTCTGCTTCCAGCTTTG
TGTAATTCTCTTTGCCAGCTGCACAAAGCTGATTTTTTCCAAAGTCTAAAGACTGAGCTCACCTGGCTAGATTGTTGTGTGTTTTGTTGA
ATTTTTTCATAATGTAATGCCGTATTTATTGTTTTTAAAATGAAAGGAATACTAATAAGTCTTAAAAGTTCCTTCATGCATAAGATTTTT
TTCCAGTTACTGGGTTTAACTGGTGTACATTAATTAGATGTCCATACTGTATTTTGTTTGCATTAAGTAATTTTCTTTTTGACTTAGTAT
CCGGCACACAAAGTGGGTTAGTACTACAGTATTTGCGTTACTTTAAGTACTAAGTATGCAGGTTTCCTGGTACCATTGAGTTGCTGCTAT
TAAAGCTCACACACGAAATGGCTAAAAGTTACAAGTGTGCAAATTATGACTGCGTGAGCCTTAGAAAATAAAATGTATAAAGGGCAACAC
ATGAGCTGTCAAACAGTGTTAGGAGTGTGTTTATATGTACAGAGTTGTGCATAGCAATCGTTTTATTTAAGTTGATATGTAGTCTACTCA
CATTTTCATTATTTAGCAATTTTGTACAAAAATAGCAATTAATTTGTAAACACTGCCAGAATACTTTCTAGCTGCTTTGTAATTTTTTAA
GAGTGTTATTTTGTTTTTGTTTTTCTGTTCTTTGTTGTGGCTCTTGTTTTCATTTTTGTTGTACGTGTAGATCTGTAAATAAAATTGCAG
TATTTAAAGCTTAAGCTTTCAGGAAAAAGAAAATAAGAATTCAGTGTGTGCATGACAACTCGTGTGTATGAGAAGGAGGGATATGAAGGA
AGATGGCTTGCAGAGTAAGTCGGGTGGCAATTGTCAGGGTGTGGGAATTTCTTTTCCTACGGGGTACGTGATTTTGTAAAAAGGAAGTAT

>15329_15329_6_CDKAL1-E2F3_CDKAL1_chr6_20739846_ENST00000378624_E2F3_chr6_20488343_ENST00000535432_length(amino acids)=218AA_BP=86
MLSRRYEGEIPKNICKRKKTVHQVTENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGSLQI
HLASTQGPIEVYLCPEETETHSPMKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEGPFVNLLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDKAL1-E2F3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDKAL1-E2F3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDKAL1-E2F3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource