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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CDKN2A-CDKN2A (FusionGDB2 ID:15398)

Fusion Gene Summary for CDKN2A-CDKN2A

Fusion gene summary

Fusion gene information	Fusion gene name: CDKN2A-CDKN2A
	Fusion gene ID: 15398
		Hgene	Tgene
	Gene symbol	CDKN2A	CDKN2A
	Gene ID	1029	1029
	Gene name	cyclin dependent kinase inhibitor 2A	cyclin dependent kinase inhibitor 2A
	Synonyms	ARF\|CDK4I\|CDKN2\|CMM2\|INK4\|INK4A\|MLM\|MTS-1\|MTS1\|P14\|P14ARF\|P16\|P16-INK4A\|P16INK4\|P16INK4A\|P19\|P19ARF\|TP16	ARF\|CDK4I\|CDKN2\|CMM2\|INK4\|INK4A\|MLM\|MTS-1\|MTS1\|P14\|P14ARF\|P16\|P16-INK4A\|P16INK4\|P16INK4A\|P19\|P19ARF\|TP16
	Cytomap	9p21.3	9p21.3
	Type of gene	protein-coding	protein-coding
	Description	cyclin-dependent kinase inhibitor 2ACDK4 inhibitor p16-INK4alternative reading framecell cycle negative regulator betacyclin-dependent kinase 4 inhibitor Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)multiple tumor suppressor 1	cyclin-dependent kinase inhibitor 2ACDK4 inhibitor p16-INK4alternative reading framecell cycle negative regulator betacyclin-dependent kinase 4 inhibitor Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)multiple tumor suppressor 1
	Modification date	20200329	20200329
	UniProtAcc	P42771	Q96HQ2
	Ensembl transtripts involved in fusion gene	ENST00000304494, ENST00000361570, ENST00000446177, ENST00000470819, ENST00000479692, ENST00000494262, ENST00000497750, ENST00000498124, ENST00000498628, ENST00000530628, ENST00000578845, ENST00000579122, ENST00000579755,	ENST00000304494, ENST00000361570, ENST00000446177, ENST00000470819, ENST00000479692, ENST00000494262, ENST00000497750, ENST00000498124, ENST00000498628, ENST00000530628, ENST00000578845, ENST00000579122, ENST00000579755,
Fusion gene scores	* DoF score	14 X 9 X 11=1386	13 X 5 X 10=650
	# samples	17	16
	** MAII score	log2(17/1386*10)=-3.02732060599951 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/650*10)=-2.02236781302845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CDKN2A [Title/Abstract] AND CDKN2A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CDKN2A(21971017)-CDKN2A(21974777), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDKN2A	GO:0000082	G1/S transition of mitotic cell cycle	10208428
Hgene	CDKN2A	GO:0007050	cell cycle arrest	15149599
Hgene	CDKN2A	GO:0008285	negative regulation of cell proliferation	15149599
Hgene	CDKN2A	GO:0030308	negative regulation of cell growth	10208428
Hgene	CDKN2A	GO:0032088	negative regulation of NF-kappaB transcription factor activity	10353611
Hgene	CDKN2A	GO:0042326	negative regulation of phosphorylation	8259215\|10208428
Hgene	CDKN2A	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	7739547\|8259215
Tgene	CDKN2A	GO:0000082	G1/S transition of mitotic cell cycle	10208428
Tgene	CDKN2A	GO:0007050	cell cycle arrest	15149599
Tgene	CDKN2A	GO:0008285	negative regulation of cell proliferation	15149599
Tgene	CDKN2A	GO:0030308	negative regulation of cell growth	10208428
Tgene	CDKN2A	GO:0032088	negative regulation of NF-kappaB transcription factor activity	10353611
Tgene	CDKN2A	GO:0042326	negative regulation of phosphorylation	8259215\|10208428
Tgene	CDKN2A	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	7739547\|8259215

Fusion gene breakpoints across CDKN2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDKN2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CN365873	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-

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Fusion Gene ORF analysis for CDKN2A-CDKN2A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000304494	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000304494	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000361570	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000446177	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000470819	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000479692	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000494262	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000497750	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498124	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000498628	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000530628	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000578845	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579122	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000304494	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000361570	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000446177	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000470819	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000479692	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000494262	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000497750	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000498124	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000498628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000530628	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000578845	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000579122	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-
intron-intron	ENST00000579755	ENST00000579755	CDKN2A	chr9	21971017	+	CDKN2A	chr9	21974777	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CDKN2A-CDKN2A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDKN2A-CDKN2A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21971017/:21974777)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDKN2A P42771	CDKN2A Q96HQ2
FUNCTION: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. {ECO:0000269\|PubMed:16782892, ECO:0000269\|PubMed:7972006}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CDKN2A-CDKN2A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CDKN2A-CDKN2A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CDKN2A-CDKN2A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CDKN2A-CDKN2A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source