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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CDKN2B-DGKD (FusionGDB2 ID:15416)

Fusion Gene Summary for CDKN2B-DGKD

Fusion gene summary

Fusion gene information	Fusion gene name: CDKN2B-DGKD
	Fusion gene ID: 15416
		Hgene	Tgene
	Gene symbol	CDKN2B	DGKD
	Gene ID	1030	8527
	Gene name	cyclin dependent kinase inhibitor 2B	diacylglycerol kinase delta
	Synonyms	CDK4I\|INK4B\|MTS2\|P15\|TP15\|p15INK4b	DGK-delta\|DGKdelta\|dgkd-2
	Cytomap	9p21.3	2q37.1
	Type of gene	protein-coding	protein-coding
	Description	cyclin-dependent kinase 4 inhibitor BCDK inhibitory proteinCDK4B inhibitorMTS-2cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)cyclin-dependent kinases 4 and 6 binding proteinmultiple tumor suppressor 2p14-INK4bp14_CDK inhibitorp14_INK4B	diacylglycerol kinase deltaDAG kinase deltadiacylglycerol kinase, delta 130kDadiglyceride kinase delta
	Modification date	20200322	20200313
	UniProtAcc	P42772	Q16760
	Ensembl transtripts involved in fusion gene	ENST00000276925, ENST00000380142, ENST00000539462,	ENST00000489613, ENST00000409813, ENST00000264057,
Fusion gene scores	* DoF score	2 X 2 X 2=8	3 X 3 X 3=27
	# samples	2	3
	** MAII score	log2(2/8*10)=1.32192809488736	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CDKN2B [Title/Abstract] AND DGKD [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CDKN2B(22008797)-DGKD(234296903), # samples:1
Anticipated loss of major functional domain due to fusion event.	CDKN2B-DGKD seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CDKN2B-DGKD seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CDKN2B-DGKD seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDKN2B	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	8078588
Hgene	CDKN2B	GO:0042326	negative regulation of phosphorylation	8078588
Tgene	DGKD	GO:0010033	response to organic substance	12200442

Fusion gene breakpoints across CDKN2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DGKD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-0155-01B	CDKN2B	chr9	22008797	-	DGKD	chr2	234296903	+

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Fusion Gene ORF analysis for CDKN2B-DGKD

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000276925	ENST00000489613	CDKN2B	chr9	22008797	-	DGKD	chr2	234296903	+
Frame-shift	ENST00000276925	ENST00000409813	CDKN2B	chr9	22008797	-	DGKD	chr2	234296903	+
In-frame	ENST00000276925	ENST00000264057	CDKN2B	chr9	22008797	-	DGKD	chr2	234296903	+
intron-3CDS	ENST00000380142	ENST00000264057	CDKN2B	chr9	22008797	-	DGKD	chr2	234296903	+
intron-3CDS	ENST00000380142	ENST00000409813	CDKN2B	chr9	22008797	-	DGKD	chr2	234296903	+
intron-3CDS	ENST00000539462	ENST00000264057	CDKN2B	chr9	22008797	-	DGKD	chr2	234296903	+
intron-3CDS	ENST00000539462	ENST00000409813	CDKN2B	chr9	22008797	-	DGKD	chr2	234296903	+
intron-3UTR	ENST00000380142	ENST00000489613	CDKN2B	chr9	22008797	-	DGKD	chr2	234296903	+
intron-3UTR	ENST00000539462	ENST00000489613	CDKN2B	chr9	22008797	-	DGKD	chr2	234296903	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000276925

CDKN2B

chr9

22008797

ENST00000264057

DGKD

chr2

234296903

6695

566

185

4054

1289

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000276925	ENST00000264057	CDKN2B	chr9	22008797	-	DGKD	chr2	234296903	+	0.001730861	0.9982691

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Fusion Genomic Features for CDKN2B-DGKD

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CDKN2B	chr9	22008796	-	DGKD	chr2	234296902	+	0.000791437	0.9992086
CDKN2B	chr9	22008796	-	DGKD	chr2	234296902	+	0.000791437	0.9992086

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDKN2B-DGKD

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:22008797/chr2:234296903)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDKN2B P42772	DGKD Q16760
FUNCTION: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250\|UniProtKB:E9PUQ8, ECO:0000269\|PubMed:12200442, ECO:0000269\|PubMed:17880279, ECO:0000269\|PubMed:23949095, ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000276925

13_39

139.0

Repeat

Note=ANK 1%3B truncated

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000409813

8_36

1171.0

Compositional bias

Note=Pro-rich

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000264057

1145_1208

1215.0

Domain

SAM

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000264057

317_451

1215.0

Domain

DAGKc

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000264057

53_146

1215.0

Domain

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000409813

1145_1208

1171.0

Domain

SAM

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000409813

317_451

1171.0

Domain

DAGKc

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000409813

53_146

1171.0

Domain

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000264057

163_213

1215.0

Zinc finger

Phorbol-ester/DAG-type 1

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000264057

235_286

1215.0

Zinc finger

Phorbol-ester/DAG-type 2

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000409813

163_213

1171.0

Zinc finger

Phorbol-ester/DAG-type 1

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000409813

235_286

1171.0

Zinc finger

Phorbol-ester/DAG-type 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000276925

112_138

139.0

Repeat

Note=ANK 4

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000276925

46_74

139.0

Repeat

Note=ANK 2

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000276925

79_108

139.0

Repeat

Note=ANK 3

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000380142

112_138

79.0

Repeat

Note=ANK 4

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000380142

13_39

79.0

Repeat

Note=ANK 1%3B truncated

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000380142

46_74

79.0

Repeat

Note=ANK 2

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000380142

79_108

79.0

Repeat

Note=ANK 3

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000539462

112_138

79.0

Repeat

Note=ANK 4

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000539462

13_39

79.0

Repeat

Note=ANK 1%3B truncated

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000539462

46_74

79.0

Repeat

Note=ANK 2

Hgene

CDKN2B

chr9:22008797

chr2:234296903

ENST00000539462

79_108

79.0

Repeat

Note=ANK 3

Tgene

DGKD

chr9:22008797

chr2:234296903

ENST00000264057

8_36

1215.0

Compositional bias

Note=Pro-rich

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Fusion Gene Sequence for CDKN2B-DGKD

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>15416_15416_1_CDKN2B-DGKD_CDKN2B_chr9_22008797_ENST00000276925_DGKD_chr2_234296903_ENST00000264057_length(transcript)=6695nt_BP=566nt
GGGAGACGCCGGCCCCTTGGCCCAGCTGAAAACGGAATTCTTTGCCGGCTGGCTCCCCACTCTGCCAGAGCGAGGCGGGGCAGTGAGGAC
TCCGCGACGCGTCCGCACCCTGCGGCCAGAGCGGCTTTGAGCTCGGCTGCGTCCGCGCTAGGCGCTTTTTCCCAGAAGCAATCCAGGCGC
GCCCGCTGGTTCTTGAGCGCCAGGAAAAGCCCGGAGCTAACGACCGGCCGCTCGGCCACTGCACGGGGCCCCAAGCCGCAGAAGGACGAC
GGGAGGGTAATGAAGCTGAGCCCAGGTCTCCTAGGAAGGAGAGAGTGCGCCGGAGCAGCGTGGGAAAGAAGGGAAGAGTGTCGTTAAGTT
TACGGCCAACGGTGGATTATCCGGGCCGCTGCGCGTCTGGGGGCTGCGGAATGCGCGAGGAGAACAAGGGCATGCCCAGTGGGGGCGGCA
GCGATGAGGGTCTGGCCAGCGCCGCGGCGCGGGGACTAGTGGAGAAGGTGCGACAGCTCCTGGAAGCCGGCGCGGATCCCAACGGAGTCA
ACCGTTTCGGGAGGCGCGCGATCCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGAT
ACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAG
CTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACGGTCATAACTCCATGCAGGAAGCTCATCTTGTGTGCTGATAACAGAAAAGAAA
TGGAAGATTGGATTGCAGCATTAAAGACTGTGCAGAACAGGGAGCACTTTGAGCCCACCCAGTACAGCATGGACCACTTCTCAGGGATGC
ACAATTGGTACGCCTGTTCCCACGCGAGGCCGACCTACTGCAATGTGTGCCGTGAGGCTCTGTCTGGGGTCACGTCGCACGGGCTGTCCT
GCGAGGTGTGCAAATTTAAGGCCCACAAGCGCTGTGCTGTGCGTGCAACCAATAACTGCAAGTGGACCACACTGGCCTCGATCGGGAAGG
ACATCATTGAAGATGCAGATGGGATTGCAATGCCCCACCAGTGGTTGGAAGGAAACCTACCTGTGAGCGCCAAGTGCACTGTGTGCGACA
AGACCTGTGGCAGTGTGCTGCGCCTGCAGGACTGGCGCTGCCTCTGGTGCAAGGCCATGGTTCACACATCGTGTAAAGAATCCTTGCTGA
CCAAGTGCCCACTTGGCCTGTGCAAAGTGTCAGTCATCCCACCCACGGCTCTCAACAGCATCGACTCCGATGGGTTCTGGAAGGCCAGCT
GTCCTCCTTCTTGCACAAGCCCACTGTTGGTCTTCGTCAATTCAAAAAGTGGGGACAACCAGGGTGTGAAGTTCCTCAGAAGATTCAAAC
AGCTACTAAACCCCGCCCAGGTCTTCGACCTCATGAACGGAGGCCCACACCTCGGCTTACGGTTATTCCAGAAGTTTGACACATTCCGGA
TTCTGGTTTGTGGCGGGGATGGAAGTGTTGGCTGGGTCCTCTCCGAAATCGACAGCCTCAACCTTCATAAACAGTGTCAGCTGGGAGTGC
TGCCGCTCGGCACAGGGAACGACTTGGCCCGAGTACTGGGCTGGGGCTCAGCCTGCGATGACGACACCCAGCTCCCCCAGATCTTGGAGA
AGTTGGAGAGAGCCAGCACCAAGATGCTGGACAGGTGGAGCGTCATGGCATACGAGGCCAAGCTCCCCCGGCAGGCCTCCTCCTCTACCG
TCACCGAAGACTTCAGCGAGGATTCCGAGGTACAGCAGATTCTCTTCTATGAAGACTCGGTTGCAGCCCACCTTTCTAAAATCCTCACCT
CGGACCAGCACTCGGTGGTCATCTCCTCGGCCAAAGTGCTCTGTGAGACGGTGAAGGACTTCGTGGCACGGGTGGGGAAGGCCTATGAGA
AGACGACCGAGAGCTCGGAGGAGTCAGAGGTCATGGCCAAGAAGTGCTCTGTCCTGAAAGAGAAGCTGGATTCCCTTCTCAAGACCTTGG
ACGATGAGTCCCAGGCCTCGTCCTCTCTGCCCAACCCGCCCCCCACCATTGCCGAGGAGGCTGAAGATGGAGATGGGTCGGGCAGCATCT
GCGGTTCCACCGGAGACCGCTTGGTGGCATCAGCTTGCCCGGCCCGGCCGCAGATATTCCGGCCTCGAGAACAGCTCATGCTGAGAGCCA
ACAGCCTGAAGAAAGCAATTCGTCAGATCATAGAACACACAGAAAAAGCTGTCGATGAGCAGAATGCCCAGACCCAGGAGCAGGAGGGCT
TCGTCCTGGGCCTCTCTGAGTCAGAGGAGAAGATGGACCACAGAGTGTGCCCACCACTGTCCCACAGCGAGAGCTTCGGGGTCCCCAAGG
GGAGGAGCCAGCGCAAAGTGTCGAAATCTCCGTGTGAAAAGCTGATCAGCAAAGGGAGTCTGTCCCTAGGCAGTTCTGCTTCCCTTCCGC
CCCAGCCGGGAAGCCGGGACGGCCTGCCTGCGCTCAACACCAAGATCCTGTACCCAAATGTCCGGGCTGGAATGTCTGGTTCCTTACCCG
GTGGCTCAGTCATCAGTCGCCTGTTAATTAATGCTGATCCCTTCAACTCTGAACCAGAAACCCTAGAGTATTACACGGAGAAATGTGTCA
TGAACAACTATTTTGGCATTGGCCTGGATGCGAAGATATCCCTGGACTTTAACAACAAGCGCGATGAGCACCCAGAGAAGTGCAGGAGCC
GAACCAAGAACATGATGTGGTATGGAGTTCTTGGAACCAAAGAGTTGCTGCACAGAACCTACAAGAACCTGGAGCAAAAGGTCTTGCTGG
AGTGTGACGGGCGACCCATCCCACTCCCCAGTCTTCAGGGAATTGCTGTCCTTAACATTCCCAGCTATGCCGGAGGAACCAACTTCTGGG
GGGGTACCAAGGAAGATGATACTTTCGCAGCTCCATCATTCGATGACAAGATTCTGGAGGTGGTCGCCGTGTTCGGCAGCATGCAGATGG
CCGTCTCTCGAGTCATCAGGCTACAGCATCATCGGATCGCCCAGTGTCGCACGGTGAAGATCTCCATCCTTGGGGATGAGGGCGTGCCTG
TGCAGGTGGACGGAGAGGCCTGGGTCCAGCCGCCAGGGTACATTCGGATTGTCCACAAGAACCGGGCACAGACACTGACCAGAGACAGGG
CATTTGAGAGCACCCTGAAGTCCTGGGAAGACAAGCAGAAGTGCGAGCTGCCCCGCCCTCCATCCTGTTCCCTGCACCCGGAGATGCTGT
CCGAGGAGGAGGCCACCCAGATGGACCAGTTTGGGCAGGCAGCAGGGGTCCTCATTCACAGTATCCGAGAAATAGCTCAGTCTCACCGGG
ACATGGAGCAGGAACTGGCCCACGCCGTCAATGCCAGCTCCAAGTCCATGGACCGTGTGTATGGCAAGCCCAGAACCACAGAGGGGCTCA
ACTGCAGCTTCGTCCTGGAAATGGTGAATAACTTCAGAGCTCTGCGCAGTGAGACGGAGCTGCTGCTGTCTGGGAAGATGGCCCTGCAGC
TGGATCCGCCTCAGAAGGAGCAGCTGGGGAGTGCTCTTGCCGAGATGGACCGACAGCTCAGGAGGCTGGCAGACACCCCGTGGCTCTGCC
AGTCCGCAGAGCCCGGCGACGAAGAGAGTGTGATGCTGGATCTTGCCAAGCGCAGTCGCAGTGGTAAATTCCGCCTCGTGACCAAGTTTA
AAAAGGAGAAAAACAACAAGAACAAAGAAGCTCACAGTAGCCTGGGAGCCCCGGTTCACCTCTGGGGGACAGAGGAGGTTGCTGCCTGGC
TGGAGCACCTCAGTCTCTGTGAGTATAAGGACATCTTCACACGGCACGACATCCGGGGCTCTGAGCTCCTGCACCTGGAGCGGAGGGACC
TCAAGGACCTGGGCGTGACCAAGGTGGGCCACATGAAGAGGATCCTGTGTGGCATCAAGGAGCTGAGCCGCAGCGCCCCCGCCGTCGAGG
CCTAGCCTCTGTCCTCTCAGCCTGTGGCCTCCACATCCCCGCCGCCGAGGCCTAGCCTCCGCCCTCTCAGCCTGTGGCCTCTGCGCCTCC
TGCCACTGAGGCCCTGGGCAGATGCTGCAGCCCGCCCCCTTCTCATGGTGCTACTTCCTCTGTCAGCTACAGAAAGCCTCCGTGACACCG
TCCACCAGAGCTCTGGGGTCTCGAACATAACAACACAGCTACCTTTGAAACAACACTTTCTCCAGCTCAGAGTCACCTGGGGCACATGTG
TCACGGCCACTCAGCTCTCGCCCGCCTGTGCTGTGGGCCAGGGAATCCAGCGGCGTCTGGCCTCCTGGGCACTGCTTGCCTGGCCTCGTG
CTTGGATTGTCCCGGGGGCTCCTCTCCGTGTGTCCTTCTGTGGCCGCACCGTGTGGCTCCGCCTCCTGGCCCCCAGCCAGTTCTCAGAAA
CGTGGCTGGGGCCCAGCACAGCAGCCTGCAAGGGCCCCTGTTTGTTGATGCAGCTTTTGTTGAACAAAAATCGTGCTCTTTCCTGGTTTG
AAAGTAGCATGGATGTTTCCAGTCTTGTTGATTGTAATTTGACGTGAAGAGAAAAAAAAATTCCTCCTGCGTGAGCCAAGGCAGCGGGTG
CTGTTTCCCAGGCGGGGAGCCCCTCCCTGGGTGTCACAGGGCCTGTGCTCCTCCCTCCTCCATCCTCTCTCCTCCCGCTCCTCCCTCCCC
CCACTGTGGGCTGGGGACGCCTGCCCTTCTGTCTCCGGACGCTCTAGGCGAGTTCAGCTTGGGGTGTGAGTGAGACAGCTTGCCAGCTGC
ATCCCTGCAGACAGAGGATGTGTGTCCACATGAGTGTTTCTGTGTGGGAAATGCTTCCTGGCTCTGGGAAACTTTTTCTGCCCATTCTGT
GGTTCCCAGGGAGCGTGGCCCTGGTGGGCCAGGGGTGGTTTGACCTCTTCAGCCCGTCCGGTGGCCTGGAGGCCGGAGGCTCTCCTGAGT
GTCTGCCCCTGCAGTGGCTTCTTGTCGCCTGCTGCTGGGCGTGATGTCGCTGGAGGTGCTGGCAGGGACTCTGATTTGGTGGTCCGCGCT
GCCCCTGCCCTGCCTCTGTCCTGGCTCTGAACTAGTAGATGATGGTGCCAGAGGGCAGGGAGCTCGCCTGGGGAGAGGGCTGTGCCCCGT
AGGGACAGTGCCCAGGTGAAGGATGCCCCTGGTCCTCCAGGGCACTGACTTTGCCCTTTTTTCCCGTTGATAGTCATGGCTCAGAGGTGC
TTGTAAATGTCTTGGGAAGAGGTTTCTGTAACCCCTGCCCTGGTGTGAGGAGGAAATGGCTCTGGCCTGGCTGCCTGGCCGTGGCTTCTC
TTTGGCTCCCAAAGAGAAGGACAGTGTTGGGAGTATCTGCCGTGGCTTCTCTTTGGCTCCCAAAGAGAAGGACAGTGTTGGGAGTATCTG
CCGGCGCTGTCCAGGTCCTTTAGTCAGCGTCACTCCATCTGATGTGCAGAAGCTGGGCTGCACCTGCGGGGGTGGGCATAGACCGGGCTG
GGTCTGCAGCAGCCCCTGGTCCTGAGCAGGCGGCAGTGAACAGCACTGGCCCACCTCCCACTCACAGCCCCTCTGTCCCCTCTGCAGTGC
ACCCAGGTGGGCCCCTCTGCGTGCCTTTGGGTGCTCCCCTCTCGTGGTCGTTCTGGCCCGAGGCCCTTAGAGTATGGAGGCTGAGCCAGG
CCTTGGGTTTCCCCAGCACAGCCTCCTGTCGCTGCATGCGACGTGTTGGGATTTTTGGATGAAAGACTCTCCCACGCTCTGTTGGTGGAC
TTAGCTGCCTCACTGGAAGTGATGTGGGTGGAAGGTGGTTGTATGTTACCTTTTCCACCTCTCATTGTTTTCCCCAGAACATTGTAGATG
GGGGTTGGCAGAGGGAGAAATAAGCCAGCCACGGCAGTCGCTTGGTTTCCCAGGTGGAATGGGCTAACACAGGAGATGATGGGAACCTGT
CCCGCAGTCCCTGCATGACCATTGGCCCTGCTGGCCTGGCGATGTGGGCATCCTGGGGTTCTTAGGGTCCCAGAACAAGCCCCAGGCAAG
CTGGAACTTGGGTGGGGAGGGGACATGAGGAGGATAAACAGCTGACTGTGGCTTCAAGGACATCAGGGCCACCCCAAGTCCTCAGTGTCC
TACTCCTGGCAAGGAGTTGGGTTTGGATCAAAAGTGTTTAAAATTAATATGTTGTCAGTGATTAGAACAACACTGTTTACATAAAAACCA
TTTTTCTAATTCTAACAAGTTAGAATGTGAGGAAGGAATGAACATGAGTGTTTAGGAACCTGCCCTTTGGTGCTGGGCTGGCGTCCCGCA
CTGGGGTGTCCTCGCTGTCTGGGGGCTGCTCTGCTGCCCCGGCCCAGGTCCCCTTGTGGTGTTGCCAGACGGGCCTCATGGTCTGCTGTG
CAGAGAGAGGCAGGAAGGATCCCTGAAGAGTCTTGGAGAAAAGGTTCTGTGCCCTCAGGTGGGGCTTACCCCCTCGTATTTATAATCTTA
ATTTATATAGTGACCACCGTGGAAACAAACGCCTCTTGTATTGTCATGTACATAGTCCATACCTGAGTGCTGTACATAAGTTGTTCTGTG

>15416_15416_1_CDKN2B-DGKD_CDKN2B_chr9_22008797_ENST00000276925_DGKD_chr2_234296903_ENST00000264057_length(amino acids)=1289AA_BP=126
MVLERQEKPGANDRPLGHCTGPQAAEGRREGNEAEPRSPRKERVRRSSVGKKGRVSLSLRPTVDYPGRCASGGCGMREENKGMPSGGGSD
EGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAE
SSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCE
VCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTK
CPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRIL
VCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVT
EDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCSVLKEKLDSLLKTLDD
ESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFV
LGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKILYPNVRAGMSGSLPGG
SVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLEC
DGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQ
VDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDM
EQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQS
AEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLK

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Fusion Gene PPI Analysis for CDKN2B-DGKD

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CDKN2B-DGKD

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CDKN2B-DGKD

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source