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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACSS3-AVIL (FusionGDB2 ID:1546)

Fusion Gene Summary for ACSS3-AVIL

check button Fusion gene summary
Fusion gene informationFusion gene name: ACSS3-AVIL
Fusion gene ID: 1546
HgeneTgene
Gene symbol

ACSS3

AVIL

Gene ID

79611

10677

Gene nameacyl-CoA synthetase short chain family member 3advillin
Synonyms-ADVIL|DOC6|NPHS21|p92
Cytomap

12q21.31

12q14.1

Type of geneprotein-codingprotein-coding
Descriptionacyl-CoA synthetase short-chain family member 3, mitochondrialAMP-binding enzyme, 33217acetate--CoA ligase 3propionate--CoA ligaseadvillin
Modification date2020031320200313
UniProtAcc.

O75366

Ensembl transtripts involved in fusion geneENST00000261206, ENST00000548058, 
ENST00000548324, 		ENST00000550083, 
ENST00000257861, ENST00000537081, 
Fusion gene scores* DoF score9 X 7 X 2=12620 X 12 X 9=2160
# samples 820
** MAII scorelog2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/2160*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACSS3 [Title/Abstract] AND AVIL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACSS3(81472210)-AVIL(58204910), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACSS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AVIL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HQ-01AACSS3chr12

81472210

+AVILchr12

58204910

-
ChimerDB4SARCTCGA-3R-A8YX-01AACSS3chr12

81472210

-AVILchr12

58204910

-
ChimerDB4SARCTCGA-3R-A8YX-01AACSS3chr12

81472210

+AVILchr12

58204910

-


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Fusion Gene ORF analysis for ACSS3-AVIL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261206ENST00000550083ACSS3chr12

81472210

+AVILchr12

58204910

-
5CDS-intronENST00000548058ENST00000550083ACSS3chr12

81472210

+AVILchr12

58204910

-
In-frameENST00000261206ENST00000257861ACSS3chr12

81472210

+AVILchr12

58204910

-
In-frameENST00000261206ENST00000537081ACSS3chr12

81472210

+AVILchr12

58204910

-
In-frameENST00000548058ENST00000257861ACSS3chr12

81472210

+AVILchr12

58204910

-
In-frameENST00000548058ENST00000537081ACSS3chr12

81472210

+AVILchr12

58204910

-
intron-3CDSENST00000548324ENST00000257861ACSS3chr12

81472210

+AVILchr12

58204910

-
intron-3CDSENST00000548324ENST00000537081ACSS3chr12

81472210

+AVILchr12

58204910

-
intron-intronENST00000548324ENST00000550083ACSS3chr12

81472210

+AVILchr12

58204910

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000548058ACSS3chr1281472210+ENST00000537081AVILchr1258204910-384312217393342867
ENST00000548058ACSS3chr1281472210+ENST00000257861AVILchr1258204910-334312217393342868
ENST00000261206ACSS3chr1281472210+ENST00000537081AVILchr1258204910-2994372642493809
ENST00000261206ACSS3chr1281472210+ENST00000257861AVILchr1258204910-2494372642493810

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000548058ENST00000537081ACSS3chr1281472210+AVILchr1258204910-0.0019426670.9980573
ENST00000548058ENST00000257861ACSS3chr1281472210+AVILchr1258204910-0.0026892140.99731076
ENST00000261206ENST00000537081ACSS3chr1281472210+AVILchr1258204910-0.0021655450.9978345
ENST00000261206ENST00000257861ACSS3chr1281472210+AVILchr1258204910-0.0034328760.99656713

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Fusion Genomic Features for ACSS3-AVIL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACSS3-AVIL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:81472210/chr12:58204910)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AVIL

O75366

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling (PubMed:29058690). May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAVILchr12:81472210chr12:58204910ENST00000257861219753_819112820.0DomainHP
TgeneAVILchr12:81472210chr12:58204910ENST00000537081219753_819105813.0DomainHP
TgeneAVILchr12:81472210chr12:58204910ENST00000257861219135_143112820.0RegionPolyphosphoinositide binding
TgeneAVILchr12:81472210chr12:58204910ENST00000257861219731_819112820.0RegionHeadpiece
TgeneAVILchr12:81472210chr12:58204910ENST00000537081219109_116105813.0RegionPolyphosphoinositide binding
TgeneAVILchr12:81472210chr12:58204910ENST00000537081219135_143105813.0RegionPolyphosphoinositide binding
TgeneAVILchr12:81472210chr12:58204910ENST00000537081219731_819105813.0RegionHeadpiece
TgeneAVILchr12:81472210chr12:58204910ENST00000257861219145_185112820.0RepeatNote=Gelsolin-like 2
TgeneAVILchr12:81472210chr12:58204910ENST00000257861219262_306112820.0RepeatNote=Gelsolin-like 3
TgeneAVILchr12:81472210chr12:58204910ENST00000257861219403_454112820.0RepeatNote=Gelsolin-like 4
TgeneAVILchr12:81472210chr12:58204910ENST00000257861219525_565112820.0RepeatNote=Gelsolin-like 5
TgeneAVILchr12:81472210chr12:58204910ENST00000257861219628_669112820.0RepeatNote=Gelsolin-like 6
TgeneAVILchr12:81472210chr12:58204910ENST00000537081219145_185105813.0RepeatNote=Gelsolin-like 2
TgeneAVILchr12:81472210chr12:58204910ENST00000537081219262_306105813.0RepeatNote=Gelsolin-like 3
TgeneAVILchr12:81472210chr12:58204910ENST00000537081219403_454105813.0RepeatNote=Gelsolin-like 4
TgeneAVILchr12:81472210chr12:58204910ENST00000537081219525_565105813.0RepeatNote=Gelsolin-like 5
TgeneAVILchr12:81472210chr12:58204910ENST00000537081219628_669105813.0RepeatNote=Gelsolin-like 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACSS3chr12:81472210chr12:58204910ENST00000548058+116425_427103687.0Nucleotide bindingATP
HgeneACSS3chr12:81472210chr12:58204910ENST00000548058+116446_451103687.0Nucleotide bindingATP
HgeneACSS3chr12:81472210chr12:58204910ENST00000548324+111425_4270369.0Nucleotide bindingATP
HgeneACSS3chr12:81472210chr12:58204910ENST00000548324+111446_4510369.0Nucleotide bindingATP
HgeneACSS3chr12:81472210chr12:58204910ENST00000548058+116227_230103687.0RegionCoenzyme A binding
HgeneACSS3chr12:81472210chr12:58204910ENST00000548324+111227_2300369.0RegionCoenzyme A binding
TgeneAVILchr12:81472210chr12:58204910ENST00000257861219109_116112820.0RegionPolyphosphoinositide binding
TgeneAVILchr12:81472210chr12:58204910ENST000002578612191_731112820.0RegionCore
TgeneAVILchr12:81472210chr12:58204910ENST000005370812191_731105813.0RegionCore
TgeneAVILchr12:81472210chr12:58204910ENST0000025786121924_73112820.0RepeatNote=Gelsolin-like 1
TgeneAVILchr12:81472210chr12:58204910ENST0000053708121924_73105813.0RepeatNote=Gelsolin-like 1


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Fusion Gene Sequence for ACSS3-AVIL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1546_1546_1_ACSS3-AVIL_ACSS3_chr12_81472210_ENST00000261206_AVIL_chr12_58204910_ENST00000257861_length(transcript)=2494nt_BP=372nt
GGCCCCAGGAAGTTGCAAGAGTACCATTTGTCGCACACTCGGGGACCGCGGGTGGCCGGAGGAGATGAAACCGTCTTGGCTGCAGTGTCG
TAAAGTCACCAGCGCCGGGGGGCTCGGAGGGCCCTTGCCTGGGTCCTCTCCGGCCCGGGGAGCCGGTGCGGCCCTCAGGGCTTTAGTGGT
CCCGGGCCCGCGGGGCGGTCTCGGGGGCCGGGGATGCAGGGCACTGTCCTCCGGCAGTGGCAGCGAGTACAAGACCCACTTCGCAGCCTC
GGTGACCGACCCCGAGAGGTTCTGGGGCAAAGCTGCCGAGCAGATCAGCTGGTACAAGCCCTGGACCAAAACGCTGGAGAACAAACACTC
GCCCTCTACCAGCTACAAGCAGGGGGGTGTCGCCTCTGGGATGAAGCACGTGGAGACCAATACCTACGACGTGAAGCGGCTGCTACATGT
GAAAGGGAAAAGAAACATCAGGGCTACCGAGGTGGAAATGAGCTGGGACAGTTTCAACCGAGGTGATGTCTTCTTGCTGGACCTTGGGAA
AGTCATCATCCAATGGAATGGCCCAGAGAGCAACAGTGGGGAGCGCCTGAAGGCTATGCTTCTGGCAAAGGATATTCGAGACAGGGAGCG
AGGGGGCCGTGCTAAAATAGGAGTGATCGAGGGAGACAAGGAGGCAGCCAGCCCAGAGCTGATGAAGGTCCTTCAGGACACCCTTGGCCG
ACGCTCCATTATCAAGCCTACAGTCCCTGATGAGATCATAGATCAGAAGCAGAAATCAACTATCATGTTGTATCATATCTCAGATTCAGC
TGGGCAGCTGGCAGTCACAGAGGTAGCAACAAGGCCTCTGGTCCAGGACTTACTGAACCATGATGACTGCTACATCCTGGACCAAAGTGG
AACCAAAATCTACGTGTGGAAAGGAAAAGGAGCCACAAAGGCTGAAAAACAGGCAGCCATGTCTAAAGCGCTGGGCTTCATCAAGATGAA
GAGCTACCCCAGCAGCACCAATGTGGAGACCGTCAACGATGGTGCTGAGTCGGCCATGTTCAAGCAGCTGTTCCAGAAGTGGTCAGTAAA
GGACCAGACCATGGGCCTGGGGAAAACGTTCAGCATTGGTAAAATTGCTAAAGTTTTCCAGGATAAATTTGATGTGACTCTGCTACACAC
CAAGCCAGAGGTAGCTGCCCAGGAAAGAATGGTCGATGATGGCAACGGAAAAGTTGAGGTCTGGAGAATTGAGAACCTGGAGCTGGTCCC
TGTGGAGTATCAATGGTATGGCTTCTTTTATGGGGGAGACTGTTATCTGGTCCTCTACACATACGAGGTAAATGGGAAGCCACATCACAT
CTTGTACATCTGGCAGGGCCGCCACGCCTCACAGGATGAGCTGGCAGCCTCAGCATACCAGGCAGTGGAGGTGGATCGGCAGTTTGATGG
GGCTGCTGTGCAGGTTCGAGTCAGGATGGGAACGGAGCCACGCCACTTCATGGCCATCTTCAAAGGGAAGCTAGTTATCTTTGAGGGTGG
GACTTCCAGGAAGGGAAATGCCGAGCCTGACCCTCCAGTAAGACTCTTCCAAATTCATGGAAATGACAAATCTAACACCAAAGCAGTGGA
AGTTCCAGCCTTTGCCTCCTCCCTAAACTCCAATGATGTCTTTCTGCTGCGAACTCAGGCAGAGCACTACCTGTGGTATGGCAAGGGGTC
TAGTGGGGATGAGCGGGCAATGGCTAAGGAGCTGGCCAGCCTTCTCTGTGATGGCAGCGAGAACACTGTGGCCGAGGGCCAGGAGCCAGC
CGAGTTCTGGGACCTACTGGGAGGGAAAACTCCCTATGCCAATGATAAAAGACTTCAGCAGGAAATCCTAGATGTCCAGTCTCGTCTCTT
TGAATGTTCCAATAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTTCACCCAGGATGACCTGAACCCTACTGACGTGATGCTCCT
AGATACCTGGGACCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCACGGAGAAGGAGAGTGCCCTTGCCACAGCACAGCAGTACCT
GCACACTCACCCCAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAAGCAGGGGTTTGAGCCTCCCATCTTCACAGGCTGGTTCCT
AGCCTGGGACCCTAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCAC
TGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAA
TCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGG

>1546_1546_1_ACSS3-AVIL_ACSS3_chr12_81472210_ENST00000261206_AVIL_chr12_58204910_ENST00000257861_length(amino acids)=810AA_BP=100
MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPW
TKTLENKHSPSTSYKQGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKAMLL
AKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHD
DCYILDQSGTKIYVWKGKGATKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFSIGKIAKVFQD
KFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQA
VEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSNDVFLLRTQAE
HYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDD
LNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELG
DAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLFX

--------------------------------------------------------------
>1546_1546_2_ACSS3-AVIL_ACSS3_chr12_81472210_ENST00000261206_AVIL_chr12_58204910_ENST00000537081_length(transcript)=2994nt_BP=372nt
GGCCCCAGGAAGTTGCAAGAGTACCATTTGTCGCACACTCGGGGACCGCGGGTGGCCGGAGGAGATGAAACCGTCTTGGCTGCAGTGTCG
TAAAGTCACCAGCGCCGGGGGGCTCGGAGGGCCCTTGCCTGGGTCCTCTCCGGCCCGGGGAGCCGGTGCGGCCCTCAGGGCTTTAGTGGT
CCCGGGCCCGCGGGGCGGTCTCGGGGGCCGGGGATGCAGGGCACTGTCCTCCGGCAGTGGCAGCGAGTACAAGACCCACTTCGCAGCCTC
GGTGACCGACCCCGAGAGGTTCTGGGGCAAAGCTGCCGAGCAGATCAGCTGGTACAAGCCCTGGACCAAAACGCTGGAGAACAAACACTC
GCCCTCTACCAGCTACAAGCAGGGGGGTGTCGCCTCTGGGATGAAGCACGTGGAGACCAATACCTACGACGTGAAGCGGCTGCTACATGT
GAAAGGGAAAAGAAACATCAGGGCTACCGAGGTGGAAATGAGCTGGGACAGTTTCAACCGAGGTGATGTCTTCTTGCTGGACCTTGGGAA
AGTCATCATCCAATGGAATGGCCCAGAGAGCAACAGTGGGGAGCGCCTGAAGGCTATGCTTCTGGCAAAGGATATTCGAGACAGGGAGCG
AGGGGGCCGTGCTAAAATAGGAGTGATCGAGGGAGACAAGGAGGCAGCCAGCCCAGAGCTGATGAAGGTCCTTCAGGACACCCTTGGCCG
ACGCTCCATTATCAAGCCTACAGTCCCTGATGAGATCATAGATCAGAAGCAGAAATCAACTATCATGTTGTATCATATCTCAGATTCAGC
TGGGCAGCTGGCAGTCACAGAGGTAGCAACAAGGCCTCTGGTCCAGGACTTACTGAACCATGATGACTGCTACATCCTGGACCAAAGTGG
AACCAAAATCTACGTGTGGAAAGGAAAAGGAGCCACAAAGGCTGAAAAACAGGCAGCCATGTCTAAAGCGCTGGGCTTCATCAAGATGAA
GAGCTACCCCAGCAGCACCAATGTGGAGACCGTCAACGATGGTGCTGAGTCGGCCATGTTCAAGCAGCTGTTCCAGAAGTGGTCAGTAAA
GGACCAGACCATGGGCCTGGGGAAAACGTTCAGCATTGGTAAAATTGCTAAAGTTTTCCAGGATAAATTTGATGTGACTCTGCTACACAC
CAAGCCAGAGGTAGCTGCCCAGGAAAGAATGGTCGATGATGGCAACGGAAAAGTTGAGGTCTGGAGAATTGAGAACCTGGAGCTGGTCCC
TGTGGAGTATCAATGGTATGGCTTCTTTTATGGGGGAGACTGTTATCTGGTCCTCTACACATACGAGGTAAATGGGAAGCCACATCACAT
CTTGTACATCTGGCAGGGCCGCCACGCCTCACAGGATGAGCTGGCAGCCTCAGCATACCAGGCAGTGGAGGTGGATCGGCAGTTTGATGG
GGCTGCTGTGCAGGTTCGAGTCAGGATGGGAACGGAGCCACGCCACTTCATGGCCATCTTCAAAGGGAAGCTAGTTATCTTTGAGGGTGG
GACTTCCAGGAAGGGAAATGCCGAGCCTGACCCTCCAGTAAGACTCTTCCAAATTCATGGAAATGACAAATCTAACACCAAAGCAGTGGA
AGTTCCAGCCTTTGCCTCCTCCCTAAACTCCAATGATGTCTTTCTGCTGCGAACTCAGGCAGAGCACTACCTGTGGTATGGCAAGGGGTC
TAGTGGGGATGAGCGGGCAATGGCTAAGGAGCTGGCCAGCCTTCTCTGTGATGGCAGCGAGAACACTGTGGCCGAGGGCCAGGAGCCAGC
CGAGTTCTGGGACCTACTGGGAGGGAAAACTCCCTATGCCAATGATAAAAGACTTCAGCAGGAAATCCTAGATGTCCAGTCTCGTCTCTT
TGAATGTTCCAATAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTTCACCCAGGATGACCTGAACCCTACTGACGTGATGCTCCT
AGATACCTGGGACCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCACGGAGAAGGAGAGTGCCCTTGCCACAGCACAGCAGTACCT
GCACACTCACCCCAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAAGCAGGGGTTTGAGCCTCCCATCTTCACAGGCTGGTTCCT
AGCCTGGGACCCTAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCAC
TGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAA
TCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGG
GCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAAAGCAAGAAGGCCTATACCTATTGCAA
GGCCACAGAAAAGAGCAGATAGTGCCAATATCAGGAAATAATTTATCCACCAATTTCTGCCTGACATTCAGCTACTTAATTTAGATATAA
TAGAGTCTGCAAATCACGGCATGTTCTCCATTTTTTCTCATCCTTGCATTCCTTGCTTGTTATATACCTAAAATGTTAACCATATAGTTT
TTGGGTTTTGTGGCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAAACTGCATAAATCTGGAGAAATCAAAAGAAAGAGAACCAAAAAA
CAATGCTTAAAATGTTTAATAACTTTATGTTTAATATTATACCAGGACCTACCTTTGTTTTCAATTTTAAGATGATTATTTCTAAAATCT
ATTTAGCCTGTAAATCATTGAAATCATATATGCACTCCATAGGCAAAATCCAAATACCCAGATCTGTAATGTGTCAAAGCATTTTTCACT

>1546_1546_2_ACSS3-AVIL_ACSS3_chr12_81472210_ENST00000261206_AVIL_chr12_58204910_ENST00000537081_length(amino acids)=809AA_BP=100
MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPW
TKTLENKHSPSTSYKQGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKAMLL
AKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHD
DCYILDQSGTKIYVWKGKGATKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFSIGKIAKVFQD
KFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQA
VEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSNDVFLLRTQAE
HYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDD
LNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELG

--------------------------------------------------------------
>1546_1546_3_ACSS3-AVIL_ACSS3_chr12_81472210_ENST00000548058_AVIL_chr12_58204910_ENST00000257861_length(transcript)=3343nt_BP=1221nt
CTTTCTTTTTACATTTTCCCAGTTTCCTCTTTTGATTCATCTTTACTTACTTCCTATTTTTGTTTTTTGTTTATTTGTTTGTTTTGTTTT
CTCATTAGAAAAGCCACAGAAACTCCAAGCAGGCAAATTAGAAGGGAGGCAATGCAACAAGTCCTATCTGTTCTCTGTCTAGATCACATG
CGGAGTCTGGTCAGCAGGTGAATCCGCATCCCAGTGGGGTCACCTTCCCTGTGACCTGTCAATCACCCCAAGAAGCACTTCCCAATTTGT
CTGGCACAACCTCCTTCCACTCCTCCTACCCTCTCAGTGGTCAGGAAATCCCGGAGCAGTCCTTGCCCTGGAGCTGCTTGTGTTTTTAGT
AACCAGGGACTGAGCTGATTTTGAAAAATCAATCAATCAATAAATAACAATCAAAGAGCCTTGCCTCAACGCACCGAGTTGCTGGTTTCC
TGCAGGTCAGAGGCGATGCCACCTCCACCAACGACCTTCCAAAGATTAAACCAGCCGTGTACAAACTGCTGGATTGAAAATTGAGAGATG
GGCCGTTGGCCTCCTCCTAGGAGTACTTGTGTGTTGAAATCGGAAGGACGTTCTGGAGTTTGAGCGCGATTTTTCCCGGAAGGCTGCGGG
GTTGGAAGTGCATGTTGGGGTTTGGATCTCGTGCAGCAGCGCAACTAACCTGCTGCAACGGCGCTGTGACACCCCTGTCCCGGGGCCCCC
ACTTTAGCCTGTTGCTTCTCTGGTCGCTCCAGGTCGGTTTTTCCCGGCGACTCTAGTGTGGCTTCCAAACTTCTGGGCTCTGGGCTCACT
TCGGAATTTGCCCCCGCCCCCTACTCCCTTCCCTCAGGCCCCAGGAAGTTGCAAGAGTACCATTTGTCGCACACTCGGGGACCGCGGGTG
GCCGGAGGAGATGAAACCGTCTTGGCTGCAGTGTCGTAAAGTCACCAGCGCCGGGGGGCTCGGAGGGCCCTTGCCTGGGTCCTCTCCGGC
CCGGGGAGCCGGTGCGGCCCTCAGGGCTTTAGTGGTCCCGGGCCCGCGGGGCGGTCTCGGGGGCCGGGGATGCAGGGCACTGTCCTCCGG
CAGTGGCAGCGAGTACAAGACCCACTTCGCAGCCTCGGTGACCGACCCCGAGAGGTTCTGGGGCAAAGCTGCCGAGCAGATCAGCTGGTA
CAAGCCCTGGACCAAAACGCTGGAGAACAAACACTCGCCCTCTACCAGGTGCTACAAGCAGGGGGGTGTCGCCTCTGGGATGAAGCACGT
GGAGACCAATACCTACGACGTGAAGCGGCTGCTACATGTGAAAGGGAAAAGAAACATCAGGGCTACCGAGGTGGAAATGAGCTGGGACAG
TTTCAACCGAGGTGATGTCTTCTTGCTGGACCTTGGGAAAGTCATCATCCAATGGAATGGCCCAGAGAGCAACAGTGGGGAGCGCCTGAA
GGCTATGCTTCTGGCAAAGGATATTCGAGACAGGGAGCGAGGGGGCCGTGCTAAAATAGGAGTGATCGAGGGAGACAAGGAGGCAGCCAG
CCCAGAGCTGATGAAGGTCCTTCAGGACACCCTTGGCCGACGCTCCATTATCAAGCCTACAGTCCCTGATGAGATCATAGATCAGAAGCA
GAAATCAACTATCATGTTGTATCATATCTCAGATTCAGCTGGGCAGCTGGCAGTCACAGAGGTAGCAACAAGGCCTCTGGTCCAGGACTT
ACTGAACCATGATGACTGCTACATCCTGGACCAAAGTGGAACCAAAATCTACGTGTGGAAAGGAAAAGGAGCCACAAAGGCTGAAAAACA
GGCAGCCATGTCTAAAGCGCTGGGCTTCATCAAGATGAAGAGCTACCCCAGCAGCACCAATGTGGAGACCGTCAACGATGGTGCTGAGTC
GGCCATGTTCAAGCAGCTGTTCCAGAAGTGGTCAGTAAAGGACCAGACCATGGGCCTGGGGAAAACGTTCAGCATTGGTAAAATTGCTAA
AGTTTTCCAGGATAAATTTGATGTGACTCTGCTACACACCAAGCCAGAGGTAGCTGCCCAGGAAAGAATGGTCGATGATGGCAACGGAAA
AGTTGAGGTCTGGAGAATTGAGAACCTGGAGCTGGTCCCTGTGGAGTATCAATGGTATGGCTTCTTTTATGGGGGAGACTGTTATCTGGT
CCTCTACACATACGAGGTAAATGGGAAGCCACATCACATCTTGTACATCTGGCAGGGCCGCCACGCCTCACAGGATGAGCTGGCAGCCTC
AGCATACCAGGCAGTGGAGGTGGATCGGCAGTTTGATGGGGCTGCTGTGCAGGTTCGAGTCAGGATGGGAACGGAGCCACGCCACTTCAT
GGCCATCTTCAAAGGGAAGCTAGTTATCTTTGAGGGTGGGACTTCCAGGAAGGGAAATGCCGAGCCTGACCCTCCAGTAAGACTCTTCCA
AATTCATGGAAATGACAAATCTAACACCAAAGCAGTGGAAGTTCCAGCCTTTGCCTCCTCCCTAAACTCCAATGATGTCTTTCTGCTGCG
AACTCAGGCAGAGCACTACCTGTGGTATGGCAAGGGGTCTAGTGGGGATGAGCGGGCAATGGCTAAGGAGCTGGCCAGCCTTCTCTGTGA
TGGCAGCGAGAACACTGTGGCCGAGGGCCAGGAGCCAGCCGAGTTCTGGGACCTACTGGGAGGGAAAACTCCCTATGCCAATGATAAAAG
ACTTCAGCAGGAAATCCTAGATGTCCAGTCTCGTCTCTTTGAATGTTCCAATAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTT
CACCCAGGATGACCTGAACCCTACTGACGTGATGCTCCTAGATACCTGGGACCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCAC
GGAGAAGGAGAGTGCCCTTGCCACAGCACAGCAGTACCTGCACACTCACCCCAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAA
GCAGGGGTTTGAGCCTCCCATCTTCACAGGCTGGTTCCTAGCCTGGGACCCTAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAA
AGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCC
AAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTC
TGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAGAAAA

>1546_1546_3_ACSS3-AVIL_ACSS3_chr12_81472210_ENST00000548058_AVIL_chr12_58204910_ENST00000257861_length(amino acids)=868AA_BP=161
MVAPGRFFPATLVWLPNFWALGSLRNLPPPPTPFPQAPGSCKSTICRTLGDRGWPEEMKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAA
LRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRCYKQGGVASGMKHVETNTYD
VKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKV
LQDTLGRRSIIKPTVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKA
LGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFSIGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRI
ENLELVPVEYQWYGFFYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGK
LVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTV
AEGQEPAEFWDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESAL
ATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIA

--------------------------------------------------------------
>1546_1546_4_ACSS3-AVIL_ACSS3_chr12_81472210_ENST00000548058_AVIL_chr12_58204910_ENST00000537081_length(transcript)=3843nt_BP=1221nt
CTTTCTTTTTACATTTTCCCAGTTTCCTCTTTTGATTCATCTTTACTTACTTCCTATTTTTGTTTTTTGTTTATTTGTTTGTTTTGTTTT
CTCATTAGAAAAGCCACAGAAACTCCAAGCAGGCAAATTAGAAGGGAGGCAATGCAACAAGTCCTATCTGTTCTCTGTCTAGATCACATG
CGGAGTCTGGTCAGCAGGTGAATCCGCATCCCAGTGGGGTCACCTTCCCTGTGACCTGTCAATCACCCCAAGAAGCACTTCCCAATTTGT
CTGGCACAACCTCCTTCCACTCCTCCTACCCTCTCAGTGGTCAGGAAATCCCGGAGCAGTCCTTGCCCTGGAGCTGCTTGTGTTTTTAGT
AACCAGGGACTGAGCTGATTTTGAAAAATCAATCAATCAATAAATAACAATCAAAGAGCCTTGCCTCAACGCACCGAGTTGCTGGTTTCC
TGCAGGTCAGAGGCGATGCCACCTCCACCAACGACCTTCCAAAGATTAAACCAGCCGTGTACAAACTGCTGGATTGAAAATTGAGAGATG
GGCCGTTGGCCTCCTCCTAGGAGTACTTGTGTGTTGAAATCGGAAGGACGTTCTGGAGTTTGAGCGCGATTTTTCCCGGAAGGCTGCGGG
GTTGGAAGTGCATGTTGGGGTTTGGATCTCGTGCAGCAGCGCAACTAACCTGCTGCAACGGCGCTGTGACACCCCTGTCCCGGGGCCCCC
ACTTTAGCCTGTTGCTTCTCTGGTCGCTCCAGGTCGGTTTTTCCCGGCGACTCTAGTGTGGCTTCCAAACTTCTGGGCTCTGGGCTCACT
TCGGAATTTGCCCCCGCCCCCTACTCCCTTCCCTCAGGCCCCAGGAAGTTGCAAGAGTACCATTTGTCGCACACTCGGGGACCGCGGGTG
GCCGGAGGAGATGAAACCGTCTTGGCTGCAGTGTCGTAAAGTCACCAGCGCCGGGGGGCTCGGAGGGCCCTTGCCTGGGTCCTCTCCGGC
CCGGGGAGCCGGTGCGGCCCTCAGGGCTTTAGTGGTCCCGGGCCCGCGGGGCGGTCTCGGGGGCCGGGGATGCAGGGCACTGTCCTCCGG
CAGTGGCAGCGAGTACAAGACCCACTTCGCAGCCTCGGTGACCGACCCCGAGAGGTTCTGGGGCAAAGCTGCCGAGCAGATCAGCTGGTA
CAAGCCCTGGACCAAAACGCTGGAGAACAAACACTCGCCCTCTACCAGGTGCTACAAGCAGGGGGGTGTCGCCTCTGGGATGAAGCACGT
GGAGACCAATACCTACGACGTGAAGCGGCTGCTACATGTGAAAGGGAAAAGAAACATCAGGGCTACCGAGGTGGAAATGAGCTGGGACAG
TTTCAACCGAGGTGATGTCTTCTTGCTGGACCTTGGGAAAGTCATCATCCAATGGAATGGCCCAGAGAGCAACAGTGGGGAGCGCCTGAA
GGCTATGCTTCTGGCAAAGGATATTCGAGACAGGGAGCGAGGGGGCCGTGCTAAAATAGGAGTGATCGAGGGAGACAAGGAGGCAGCCAG
CCCAGAGCTGATGAAGGTCCTTCAGGACACCCTTGGCCGACGCTCCATTATCAAGCCTACAGTCCCTGATGAGATCATAGATCAGAAGCA
GAAATCAACTATCATGTTGTATCATATCTCAGATTCAGCTGGGCAGCTGGCAGTCACAGAGGTAGCAACAAGGCCTCTGGTCCAGGACTT
ACTGAACCATGATGACTGCTACATCCTGGACCAAAGTGGAACCAAAATCTACGTGTGGAAAGGAAAAGGAGCCACAAAGGCTGAAAAACA
GGCAGCCATGTCTAAAGCGCTGGGCTTCATCAAGATGAAGAGCTACCCCAGCAGCACCAATGTGGAGACCGTCAACGATGGTGCTGAGTC
GGCCATGTTCAAGCAGCTGTTCCAGAAGTGGTCAGTAAAGGACCAGACCATGGGCCTGGGGAAAACGTTCAGCATTGGTAAAATTGCTAA
AGTTTTCCAGGATAAATTTGATGTGACTCTGCTACACACCAAGCCAGAGGTAGCTGCCCAGGAAAGAATGGTCGATGATGGCAACGGAAA
AGTTGAGGTCTGGAGAATTGAGAACCTGGAGCTGGTCCCTGTGGAGTATCAATGGTATGGCTTCTTTTATGGGGGAGACTGTTATCTGGT
CCTCTACACATACGAGGTAAATGGGAAGCCACATCACATCTTGTACATCTGGCAGGGCCGCCACGCCTCACAGGATGAGCTGGCAGCCTC
AGCATACCAGGCAGTGGAGGTGGATCGGCAGTTTGATGGGGCTGCTGTGCAGGTTCGAGTCAGGATGGGAACGGAGCCACGCCACTTCAT
GGCCATCTTCAAAGGGAAGCTAGTTATCTTTGAGGGTGGGACTTCCAGGAAGGGAAATGCCGAGCCTGACCCTCCAGTAAGACTCTTCCA
AATTCATGGAAATGACAAATCTAACACCAAAGCAGTGGAAGTTCCAGCCTTTGCCTCCTCCCTAAACTCCAATGATGTCTTTCTGCTGCG
AACTCAGGCAGAGCACTACCTGTGGTATGGCAAGGGGTCTAGTGGGGATGAGCGGGCAATGGCTAAGGAGCTGGCCAGCCTTCTCTGTGA
TGGCAGCGAGAACACTGTGGCCGAGGGCCAGGAGCCAGCCGAGTTCTGGGACCTACTGGGAGGGAAAACTCCCTATGCCAATGATAAAAG
ACTTCAGCAGGAAATCCTAGATGTCCAGTCTCGTCTCTTTGAATGTTCCAATAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTT
CACCCAGGATGACCTGAACCCTACTGACGTGATGCTCCTAGATACCTGGGACCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCAC
GGAGAAGGAGAGTGCCCTTGCCACAGCACAGCAGTACCTGCACACTCACCCCAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAA
GCAGGGGTTTGAGCCTCCCATCTTCACAGGCTGGTTCCTAGCCTGGGACCCTAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAA
AGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCC
AAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTC
TGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAGAAAA
GGGGCTTTTCTAAAGCAAGAAGGCCTATACCTATTGCAAGGCCACAGAAAAGAGCAGATAGTGCCAATATCAGGAAATAATTTATCCACC
AATTTCTGCCTGACATTCAGCTACTTAATTTAGATATAATAGAGTCTGCAAATCACGGCATGTTCTCCATTTTTTCTCATCCTTGCATTC
CTTGCTTGTTATATACCTAAAATGTTAACCATATAGTTTTTGGGTTTTGTGGCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAAACTG
CATAAATCTGGAGAAATCAAAAGAAAGAGAACCAAAAAACAATGCTTAAAATGTTTAATAACTTTATGTTTAATATTATACCAGGACCTA
CCTTTGTTTTCAATTTTAAGATGATTATTTCTAAAATCTATTTAGCCTGTAAATCATTGAAATCATATATGCACTCCATAGGCAAAATCC

>1546_1546_4_ACSS3-AVIL_ACSS3_chr12_81472210_ENST00000548058_AVIL_chr12_58204910_ENST00000537081_length(amino acids)=867AA_BP=161
MVAPGRFFPATLVWLPNFWALGSLRNLPPPPTPFPQAPGSCKSTICRTLGDRGWPEEMKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAA
LRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRCYKQGGVASGMKHVETNTYD
VKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKV
LQDTLGRRSIIKPTVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKA
LGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFSIGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRI
ENLELVPVEYQWYGFFYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGK
LVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTV
AEGQEPAEFWDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESAL
ATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACSS3-AVIL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACSS3-AVIL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACSS3-AVIL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource