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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEACAM5-AP1G1 (FusionGDB2 ID:15505)

Fusion Gene Summary for CEACAM5-AP1G1

check button Fusion gene summary
Fusion gene informationFusion gene name: CEACAM5-AP1G1
Fusion gene ID: 15505
HgeneTgene
Gene symbol

CEACAM5

AP1G1

Gene ID

1048

164

Gene nameCEA cell adhesion molecule 5adaptor related protein complex 1 subunit gamma 1
SynonymsCD66e|CEAADTG|CLAPG1
Cytomap

19q13.2

16q22.2

Type of geneprotein-codingprotein-coding
Descriptioncarcinoembryonic antigen-related cell adhesion molecule 5carcinoembryonic antigen related cell adhesion molecule 5meconium antigen 100AP-1 complex subunit gamma-1adapter-related protein complex 1 subunit gamma-1adaptor protein complex AP-1 subunit gamma-1adaptor related protein complex 1 gamma 1 subunitclathrin assembly protein complex 1 gamma large chainclathrin assembly protein c
Modification date2020031320200313
UniProtAcc

P06731

O43747

Ensembl transtripts involved in fusion geneENST00000221992, ENST00000398599, 
ENST00000405816, 		ENST00000564155, 
ENST00000570297, ENST00000299980, 
ENST00000393512, ENST00000423132, 
ENST00000433195, ENST00000569748, 
Fusion gene scores* DoF score10 X 11 X 4=44012 X 12 X 5=720
# samples 1014
** MAII scorelog2(10/440*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/720*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEACAM5 [Title/Abstract] AND AP1G1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEACAM5(42224127)-AP1G1(71767062), # samples:1
Anticipated loss of major functional domain due to fusion event.CEACAM5-AP1G1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCEACAM5

GO:0010832

negative regulation of myotube differentiation

8408226|10931872

HgeneCEACAM5

GO:0034109

homotypic cell-cell adhesion

10864933

HgeneCEACAM5

GO:0043066

negative regulation of apoptotic process

11448920

HgeneCEACAM5

GO:2000811

negative regulation of anoikis

10910050


check buttonFusion gene breakpoints across CEACAM5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AP1G1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8683-01ACEACAM5chr19

42224127

+AP1G1chr16

71767062

-


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Fusion Gene ORF analysis for CEACAM5-AP1G1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000221992ENST00000564155CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
5CDS-intronENST00000221992ENST00000570297CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
5CDS-intronENST00000398599ENST00000564155CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
5CDS-intronENST00000398599ENST00000570297CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
5CDS-intronENST00000405816ENST00000564155CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
5CDS-intronENST00000405816ENST00000570297CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000221992ENST00000299980CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000221992ENST00000393512CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000221992ENST00000423132CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000221992ENST00000433195CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000398599ENST00000299980CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000398599ENST00000393512CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000398599ENST00000423132CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000398599ENST00000433195CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000405816ENST00000299980CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000405816ENST00000393512CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000405816ENST00000423132CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
Frame-shiftENST00000405816ENST00000433195CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
In-frameENST00000221992ENST00000569748CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
In-frameENST00000398599ENST00000569748CEACAM5chr19

42224127

+AP1G1chr16

71767062

-
In-frameENST00000405816ENST00000569748CEACAM5chr19

42224127

+AP1G1chr16

71767062

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398599CEACAM5chr1942224127+ENST00000569748AP1G1chr1671767062-31921915811949622
ENST00000221992CEACAM5chr1942224127+ENST00000569748AP1G1chr1671767062-31621885481919623
ENST00000405816CEACAM5chr1942224127+ENST00000569748AP1G1chr1671767062-31311854171888623

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398599ENST00000569748CEACAM5chr1942224127+AP1G1chr1671767062-0.0021558770.9978441
ENST00000221992ENST00000569748CEACAM5chr1942224127+AP1G1chr1671767062-0.0023546440.9976453
ENST00000405816ENST00000569748CEACAM5chr1942224127+AP1G1chr1671767062-0.002216440.9977836

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Fusion Genomic Features for CEACAM5-AP1G1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CEACAM5-AP1G1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:42224127/chr16:71767062)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEACAM5

P06731

AP1G1

O43747

FUNCTION: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:2803308}.; FUNCTION: (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. {ECO:0000269|PubMed:18086185}.FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000221992+710145_232590848.6666666666666DomainIg-like C2-type 1
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000221992+710240_315590848.6666666666666DomainIg-like C2-type 2
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000221992+710323_410590848.6666666666666DomainIg-like C2-type 3
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000221992+71035_144590848.6666666666666DomainIg-like V-type
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000221992+710418_495590848.6666666666666DomainIg-like C2-type 4
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000221992+710501_588590848.6666666666666DomainIg-like C2-type 5
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000398599+710145_232589685.6666666666666DomainIg-like C2-type 1
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000398599+710240_315589685.6666666666666DomainIg-like C2-type 2
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000398599+710323_410589685.6666666666666DomainIg-like C2-type 3
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000398599+71035_144589685.6666666666666DomainIg-like V-type
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000398599+710418_495589685.6666666666666DomainIg-like C2-type 4
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000398599+710501_588589685.6666666666666DomainIg-like C2-type 5
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000405816+710145_232590696.0DomainIg-like C2-type 1
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000405816+710240_315590696.0DomainIg-like C2-type 2
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000405816+710323_410590696.0DomainIg-like C2-type 3
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000405816+71035_144590696.0DomainIg-like V-type
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000405816+710418_495590696.0DomainIg-like C2-type 4
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000405816+710501_588590696.0DomainIg-like C2-type 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000221992+710593_675590848.6666666666666DomainIg-like C2-type 6
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000398599+710593_675589685.6666666666666DomainIg-like C2-type 6
HgeneCEACAM5chr19:42224127chr16:71767062ENST00000405816+710593_675590696.0DomainIg-like C2-type 6
TgeneAP1G1chr19:42224127chr16:71767062ENST000002999802123702_817789823.0DomainGAE
TgeneAP1G1chr19:42224127chr16:71767062ENST000003935122224702_817792826.0DomainGAE
TgeneAP1G1chr19:42224127chr16:71767062ENST000005697482426702_817789823.0DomainGAE


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Fusion Gene Sequence for CEACAM5-AP1G1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15505_15505_1_CEACAM5-AP1G1_CEACAM5_chr19_42224127_ENST00000221992_AP1G1_chr16_71767062_ENST00000569748_length(transcript)=3162nt_BP=1885nt
CTCAGGGCAGAGGGAGGAAGGACAGCAGACCAGACAGTCACAGCAGCCTTGACAAAACGTTCCTGGAACTCAAGCTCTTCTCCACAGAGG
AGGACAGAGCAGACAGCAGAGACCATGGAGTCTCCCTCGGCCCCTCCCCACAGATGGTGCATCCCCTGGCAGAGGCTCCTGCTCACAGCC
TCACTTCTAACCTTCTGGAACCCGCCCACCACTGCCAAGCTCACTATTGAATCCACGCCGTTCAATGTCGCAGAGGGGAAGGAGGTGCTT
CTACTTGTCCACAATCTGCCCCAGCATCTTTTTGGCTACAGCTGGTACAAAGGTGAAAGAGTGGATGGCAACCGTCAAATTATAGGATAT
GTAATAGGAACTCAACAAGCTACCCCAGGGCCCGCATACAGTGGTCGAGAGATAATATACCCCAATGCATCCCTGCTGATCCAGAACATC
ATCCAGAATGACACAGGATTCTACACCCTACACGTCATAAAGTCAGATCTTGTGAATGAAGAAGCAACTGGCCAGTTCCGGGTATACCCG
GAGCTGCCCAAGCCCTCCATCTCCAGCAACAACTCCAAACCCGTGGAGGACAAGGATGCTGTGGCCTTCACCTGTGAACCTGAGACTCAG
GACGCAACCTACCTGTGGTGGGTAAACAATCAGAGCCTCCCGGTCAGTCCCAGGCTGCAGCTGTCCAATGGCAACAGGACCCTCACTCTA
TTCAATGTCACAAGAAATGACACAGCAAGCTACAAATGTGAAACCCAGAACCCAGTGAGTGCCAGGCGCAGTGATTCAGTCATCCTGAAT
GTCCTCTATGGCCCGGATGCCCCCACCATTTCCCCTCTAAACACATCTTACAGATCAGGGGAAAATCTGAACCTCTCCTGCCACGCAGCC
TCTAACCCACCTGCACAGTACTCTTGGTTTGTCAATGGGACTTTCCAGCAATCCACCCAAGAGCTCTTTATCCCCAACATCACTGTGAAT
AATAGTGGATCCTATACGTGCCAAGCCCATAACTCAGACACTGGCCTCAATAGGACCACAGTCACGACGATCACAGTCTATGCAGAGCCA
CCCAAACCCTTCATCACCAGCAACAACTCCAACCCCGTGGAGGATGAGGATGCTGTAGCCTTAACCTGTGAACCTGAGATTCAGAACACA
ACCTACCTGTGGTGGGTAAATAATCAGAGCCTCCCGGTCAGTCCCAGGCTGCAGCTGTCCAATGACAACAGGACCCTCACTCTACTCAGT
GTCACAAGGAATGATGTAGGACCCTATGAGTGTGGAATCCAGAACAAATTAAGTGTTGACCACAGCGACCCAGTCATCCTGAATGTCCTC
TATGGCCCAGACGACCCCACCATTTCCCCCTCATACACCTATTACCGTCCAGGGGTGAACCTCAGCCTCTCCTGCCATGCAGCCTCTAAC
CCACCTGCACAGTATTCTTGGCTGATTGATGGGAACATCCAGCAACACACACAAGAGCTCTTTATCTCCAACATCACTGAGAAGAACAGC
GGACTCTATACCTGCCAGGCCAATAACTCAGCCAGTGGCCACAGCAGGACTACAGTCAAGACAATCACAGTCTCTGCGGAGCTGCCCAAG
CCCTCCATCTCCAGCAACAACTCCAAACCCGTGGAGGACAAGGATGCTGTGGCCTTCACCTGTGAACCTGAGGCTCAGAACACAACCTAC
CTGTGGTGGGTAAATGGTCAGAGCCTCCCAGTCAGTCCCAGGCTGCAGCTGTCCAATGGCAACAGGACCCTCACTCTATTCAATGTCACA
AGAAATGACGCAAGAGCCTATGTATGTGGAATCCAGAACTCAGTGAGTGCAAACCGCAGTGACCCAGTCACCCTGGATGTCCTCTCAACA
GCTGCGAATGCGGATCAAGCTTACATATAATCACAAGGGCTCAGCAATGCAAGATCTAGCAGAGGTGAACAACTTTCCCCCTCAGTCCTG
GCAATGAGGGTTTGGCACCATTCTCATTCTTTATCCCACTCAATCAAAGGAACTCTGGGAAGGAGGTTGTGATTGCTGGCAAGTCCCCCC
CAACTGTACCACGGGCATGAGGAGCTGAAGAGAACTGCTGAGGAGGATTTTCCTAAAGTTACTGCTGACCTTGAAGCATTGTTAAAGACT
AATGTCCTCTCCTCCACTGTTGAGGCTGGCTGCTTCTGGAGGCTACTTTGCACTCTTCCTCTTCTCCTTTTTCCGCACTTCTCCACCCCT
CCCACATTTACAGCCAGAATCAACATTCCCTGGGCCCCTGAGGAAATAAGCAGCTGGTCTGGAGGAGAGGACTGCAATCCATGGCGAAAA
AACACTCACTTTGTCTCTGCAGCAAAGAGTTGCCCCTTCTTTCTACTGTTGTTTCTCTGTGGACTGGGCAAGGTGGGGTATTTATTCCTC
ACTAGCTGGGTTACCATCTTCAGGCACTTTTAACATCTGGCATTCGGAATGGAAATGTAATAATGGACATTAGGGAGCCCTGCCTTTTTC
TACTGGTTCCCCCAATGTTTGAAAGAGGCATTAGGCTCCTGGTAGCCTTTTCTGTGCATTGCTGTATACACACAGACACACACATGTATG
TTTGTTACCAAGAACTGGTCAGACCTTGCGAGTTTATTTGTAAACACTGGACAGATGGAGTTAAAAAGAGCTTTTGTTGAGATTTGGCAT
GAAGGATATGGTGCTCTATTTGTAATAGAAACTTCCAAGGCTCTTCCAGCTCCCCTTTCTCGCCATTCTTTAGCTGTAGTCATGAATAGT
CTCCATGATTTTCAAAATTGATTCCCTTTAAAGTGCAAAATGGTCACCTTCTAAAAGATATATTCATAGTTATTAATGACCCTATTCCCA
CCACAAATTTTAAAGTGCTCCTAAGCCCATAACTTGCCTGTTTGAACTATGGTAATGGGTGGAAGAGGAGTTCACCAGTTTCAAAGATCA
GACTCTGTATCAAAAGTACCTTTGCCCTTAGGAAGAGTGAGTATTGGAGTCATCTTATCTATTACTCCAAACCTCCCTTTTTATTTCTTG
AGCCTGGCTTGGACCTTGGCATTCCGTTTGAATTCCTTCTAACTGGAACATTTGTGTTGTATCTGTAACACTGGCACTGAAATAAAGACC

>15505_15505_1_CEACAM5-AP1G1_CEACAM5_chr19_42224127_ENST00000221992_AP1G1_chr16_71767062_ENST00000569748_length(amino acids)=623AA_BP=
MTKRSWNSSSSPQRRTEQTAETMESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWY
KGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVE
DKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTS
YRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDE
DAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYR
PGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDA

--------------------------------------------------------------
>15505_15505_2_CEACAM5-AP1G1_CEACAM5_chr19_42224127_ENST00000398599_AP1G1_chr16_71767062_ENST00000569748_length(transcript)=3192nt_BP=1915nt
GATGCTGAGAAGTACTCCTGCCCTAGGAAGAGACTCAGGGCAGAGGGAGGAAGGACAGCAGACCAGACAGTCACAGCAGCCTTGACAAAA
CGTTCCTGGAACTCAAGCTCTTCTCCACAGAGGAGGACAGAGCAGACAGCAGAGACCATGGAGTCTCCCTCGGCCCCTCCCCACAGATGG
TGCATCCCCTGGCAGAGGCTCCTGCTCACAGCCTCACTTCTAACCTTCTGGAACCCGCCCACCACTGCCAAGCTCACTATTGAATCCACG
CCGTTCAATGTCGCAGAGGGGAAGGAGGTGCTTCTACTTGTCCACAATCTGCCCCAGCATCTTTTTGGCTACAGCTGGTACAAAGGTGAA
AGAGTGGATGGCAACCGTCAAATTATAGGATATGTAATAGGAACTCAACAAGCTACCCCAGGGCCCGCATACAGTGGTCGAGAGATAATA
TACCCCAATGCATCCCTGCTGATCCAGAACATCATCCAGAATGACACAGGATTCTACACCCTACACGTCATAAAGTCAGATCTTGTGAAT
GAAGAAGCAACTGGCCAGTTCCGGGTATACCCGGAGCTGCCCAAGCCCTCCATCTCCAGCAACAACTCCAAACCCGTGGAGGACAAGGAT
GCTGTGGCCTTCACCTGTGAACCTGAGACTCAGGACGCAACCTACCTGTGGTGGGTAAACAATCAGAGCCTCCCGGTCAGTCCCAGGCTG
CAGCTGTCCAATGGCAACAGGACCCTCACTCTATTCAATGTCACAAGAAATGACACAGCAAGCTACAAATGTGAAACCCAGAACCCAGTG
AGTGCCAGGCGCAGTGATTCAGTCATCCTGAATGTCCTCTATGGCCCGGATGCCCCCACCATTTCCCCTCTAAACACATCTTACAGATCA
GGGGAAAATCTGAACCTCTCCTGCCACGCAGCCTCTAACCCACCTGCACAGTACTCTTGGTTTGTCAATGGGACTTTCCAGCAATCCACC
CAAGAGCTCTTTATCCCCAACATCACTGTGAATAATAGTGGATCCTATACGTGCCAAGCCCATAACTCAGACACTGGCCTCAATAGGACC
ACAGTCACGACGATCACAGTCTATGAGCCACCCAAACCCTTCATCACCAGCAACAACTCCAACCCCGTGGAGGATGAGGATGCTGTAGCC
TTAACCTGTGAACCTGAGATTCAGAACACAACCTACCTGTGGTGGGTAAATAATCAGAGCCTCCCGGTCAGTCCCAGGCTGCAGCTGTCC
AATGACAACAGGACCCTCACTCTACTCAGTGTCACAAGGAATGATGTAGGACCCTATGAGTGTGGAATCCAGAACAAATTAAGTGTTGAC
CACAGCGACCCAGTCATCCTGAATGTCCTCTATGGCCCAGACGACCCCACCATTTCCCCCTCATACACCTATTACCGTCCAGGGGTGAAC
CTCAGCCTCTCCTGCCATGCAGCCTCTAACCCACCTGCACAGTATTCTTGGCTGATTGATGGGAACATCCAGCAACACACACAAGAGCTC
TTTATCTCCAACATCACTGAGAAGAACAGCGGACTCTATACCTGCCAGGCCAATAACTCAGCCAGTGGCCACAGCAGGACTACAGTCAAG
ACAATCACAGTCTCTGCGGAGCTGCCCAAGCCCTCCATCTCCAGCAACAACTCCAAACCCGTGGAGGACAAGGATGCTGTGGCCTTCACC
TGTGAACCTGAGGCTCAGAACACAACCTACCTGTGGTGGGTAAATGGTCAGAGCCTCCCAGTCAGTCCCAGGCTGCAGCTGTCCAATGGC
AACAGGACCCTCACTCTATTCAATGTCACAAGAAATGACGCAAGAGCCTATGTATGTGGAATCCAGAACTCAGTGAGTGCAAACCGCAGT
GACCCAGTCACCCTGGATGTCCTCTCAACAGCTGCGAATGCGGATCAAGCTTACATATAATCACAAGGGCTCAGCAATGCAAGATCTAGC
AGAGGTGAACAACTTTCCCCCTCAGTCCTGGCAATGAGGGTTTGGCACCATTCTCATTCTTTATCCCACTCAATCAAAGGAACTCTGGGA
AGGAGGTTGTGATTGCTGGCAAGTCCCCCCCAACTGTACCACGGGCATGAGGAGCTGAAGAGAACTGCTGAGGAGGATTTTCCTAAAGTT
ACTGCTGACCTTGAAGCATTGTTAAAGACTAATGTCCTCTCCTCCACTGTTGAGGCTGGCTGCTTCTGGAGGCTACTTTGCACTCTTCCT
CTTCTCCTTTTTCCGCACTTCTCCACCCCTCCCACATTTACAGCCAGAATCAACATTCCCTGGGCCCCTGAGGAAATAAGCAGCTGGTCT
GGAGGAGAGGACTGCAATCCATGGCGAAAAAACACTCACTTTGTCTCTGCAGCAAAGAGTTGCCCCTTCTTTCTACTGTTGTTTCTCTGT
GGACTGGGCAAGGTGGGGTATTTATTCCTCACTAGCTGGGTTACCATCTTCAGGCACTTTTAACATCTGGCATTCGGAATGGAAATGTAA
TAATGGACATTAGGGAGCCCTGCCTTTTTCTACTGGTTCCCCCAATGTTTGAAAGAGGCATTAGGCTCCTGGTAGCCTTTTCTGTGCATT
GCTGTATACACACAGACACACACATGTATGTTTGTTACCAAGAACTGGTCAGACCTTGCGAGTTTATTTGTAAACACTGGACAGATGGAG
TTAAAAAGAGCTTTTGTTGAGATTTGGCATGAAGGATATGGTGCTCTATTTGTAATAGAAACTTCCAAGGCTCTTCCAGCTCCCCTTTCT
CGCCATTCTTTAGCTGTAGTCATGAATAGTCTCCATGATTTTCAAAATTGATTCCCTTTAAAGTGCAAAATGGTCACCTTCTAAAAGATA
TATTCATAGTTATTAATGACCCTATTCCCACCACAAATTTTAAAGTGCTCCTAAGCCCATAACTTGCCTGTTTGAACTATGGTAATGGGT
GGAAGAGGAGTTCACCAGTTTCAAAGATCAGACTCTGTATCAAAAGTACCTTTGCCCTTAGGAAGAGTGAGTATTGGAGTCATCTTATCT
ATTACTCCAAACCTCCCTTTTTATTTCTTGAGCCTGGCTTGGACCTTGGCATTCCGTTTGAATTCCTTCTAACTGGAACATTTGTGTTGT

>15505_15505_2_CEACAM5-AP1G1_CEACAM5_chr19_42224127_ENST00000398599_AP1G1_chr16_71767062_ENST00000569748_length(amino acids)=622AA_BP=
MTKRSWNSSSSPQRRTEQTAETMESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWY
KGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVE
DKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTS
YRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYEPPKPFITSNNSNPVEDED
AVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRP
GVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAV

--------------------------------------------------------------
>15505_15505_3_CEACAM5-AP1G1_CEACAM5_chr19_42224127_ENST00000405816_AP1G1_chr16_71767062_ENST00000569748_length(transcript)=3131nt_BP=1854nt
AGACAGTCACAGCAGCCTTGACAAAACGTTCCTGGAACTCAAGCTCTTCTCCACAGAGGAGGACAGAGCAGACAGCAGAGACCATGGAGT
CTCCCTCGGCCCCTCCCCACAGATGGTGCATCCCCTGGCAGAGGCTCCTGCTCACAGCCTCACTTCTAACCTTCTGGAACCCGCCCACCA
CTGCCAAGCTCACTATTGAATCCACGCCGTTCAATGTCGCAGAGGGGAAGGAGGTGCTTCTACTTGTCCACAATCTGCCCCAGCATCTTT
TTGGCTACAGCTGGTACAAAGGTGAAAGAGTGGATGGCAACCGTCAAATTATAGGATATGTAATAGGAACTCAACAAGCTACCCCAGGGC
CCGCATACAGTGGTCGAGAGATAATATACCCCAATGCATCCCTGCTGATCCAGAACATCATCCAGAATGACACAGGATTCTACACCCTAC
ACGTCATAAAGTCAGATCTTGTGAATGAAGAAGCAACTGGCCAGTTCCGGGTATACCCGGAGCTGCCCAAGCCCTCCATCTCCAGCAACA
ACTCCAAACCCGTGGAGGACAAGGATGCTGTGGCCTTCACCTGTGAACCTGAGACTCAGGACGCAACCTACCTGTGGTGGGTAAACAATC
AGAGCCTCCCGGTCAGTCCCAGGCTGCAGCTGTCCAATGGCAACAGGACCCTCACTCTATTCAATGTCACAAGAAATGACACAGCAAGCT
ACAAATGTGAAACCCAGAACCCAGTGAGTGCCAGGCGCAGTGATTCAGTCATCCTGAATGTCCTCTATGGCCCGGATGCCCCCACCATTT
CCCCTCTAAACACATCTTACAGATCAGGGGAAAATCTGAACCTCTCCTGCCACGCAGCCTCTAACCCACCTGCACAGTACTCTTGGTTTG
TCAATGGGACTTTCCAGCAATCCACCCAAGAGCTCTTTATCCCCAACATCACTGTGAATAATAGTGGATCCTATACGTGCCAAGCCCATA
ACTCAGACACTGGCCTCAATAGGACCACAGTCACGACGATCACAGTCTATGCAGAGCCACCCAAACCCTTCATCACCAGCAACAACTCCA
ACCCCGTGGAGGATGAGGATGCTGTAGCCTTAACCTGTGAACCTGAGATTCAGAACACAACCTACCTGTGGTGGGTAAATAATCAGAGCC
TCCCGGTCAGTCCCAGGCTGCAGCTGTCCAATGACAACAGGACCCTCACTCTACTCAGTGTCACAAGGAATGATGTAGGACCCTATGAGT
GTGGAATCCAGAACAAATTAAGTGTTGACCACAGCGACCCAGTCATCCTGAATGTCCTCTATGGCCCAGACGACCCCACCATTTCCCCCT
CATACACCTATTACCGTCCAGGGGTGAACCTCAGCCTCTCCTGCCATGCAGCCTCTAACCCACCTGCACAGTATTCTTGGCTGATTGATG
GGAACATCCAGCAACACACACAAGAGCTCTTTATCTCCAACATCACTGAGAAGAACAGCGGACTCTATACCTGCCAGGCCAATAACTCAG
CCAGTGGCCACAGCAGGACTACAGTCAAGACAATCACAGTCTCTGCGGAGCTGCCCAAGCCCTCCATCTCCAGCAACAACTCCAAACCCG
TGGAGGACAAGGATGCTGTGGCCTTCACCTGTGAACCTGAGGCTCAGAACACAACCTACCTGTGGTGGGTAAATGGTCAGAGCCTCCCAG
TCAGTCCCAGGCTGCAGCTGTCCAATGGCAACAGGACCCTCACTCTATTCAATGTCACAAGAAATGACGCAAGAGCCTATGTATGTGGAA
TCCAGAACTCAGTGAGTGCAAACCGCAGTGACCCAGTCACCCTGGATGTCCTCTCAACAGCTGCGAATGCGGATCAAGCTTACATATAAT
CACAAGGGCTCAGCAATGCAAGATCTAGCAGAGGTGAACAACTTTCCCCCTCAGTCCTGGCAATGAGGGTTTGGCACCATTCTCATTCTT
TATCCCACTCAATCAAAGGAACTCTGGGAAGGAGGTTGTGATTGCTGGCAAGTCCCCCCCAACTGTACCACGGGCATGAGGAGCTGAAGA
GAACTGCTGAGGAGGATTTTCCTAAAGTTACTGCTGACCTTGAAGCATTGTTAAAGACTAATGTCCTCTCCTCCACTGTTGAGGCTGGCT
GCTTCTGGAGGCTACTTTGCACTCTTCCTCTTCTCCTTTTTCCGCACTTCTCCACCCCTCCCACATTTACAGCCAGAATCAACATTCCCT
GGGCCCCTGAGGAAATAAGCAGCTGGTCTGGAGGAGAGGACTGCAATCCATGGCGAAAAAACACTCACTTTGTCTCTGCAGCAAAGAGTT
GCCCCTTCTTTCTACTGTTGTTTCTCTGTGGACTGGGCAAGGTGGGGTATTTATTCCTCACTAGCTGGGTTACCATCTTCAGGCACTTTT
AACATCTGGCATTCGGAATGGAAATGTAATAATGGACATTAGGGAGCCCTGCCTTTTTCTACTGGTTCCCCCAATGTTTGAAAGAGGCAT
TAGGCTCCTGGTAGCCTTTTCTGTGCATTGCTGTATACACACAGACACACACATGTATGTTTGTTACCAAGAACTGGTCAGACCTTGCGA
GTTTATTTGTAAACACTGGACAGATGGAGTTAAAAAGAGCTTTTGTTGAGATTTGGCATGAAGGATATGGTGCTCTATTTGTAATAGAAA
CTTCCAAGGCTCTTCCAGCTCCCCTTTCTCGCCATTCTTTAGCTGTAGTCATGAATAGTCTCCATGATTTTCAAAATTGATTCCCTTTAA
AGTGCAAAATGGTCACCTTCTAAAAGATATATTCATAGTTATTAATGACCCTATTCCCACCACAAATTTTAAAGTGCTCCTAAGCCCATA
ACTTGCCTGTTTGAACTATGGTAATGGGTGGAAGAGGAGTTCACCAGTTTCAAAGATCAGACTCTGTATCAAAAGTACCTTTGCCCTTAG
GAAGAGTGAGTATTGGAGTCATCTTATCTATTACTCCAAACCTCCCTTTTTATTTCTTGAGCCTGGCTTGGACCTTGGCATTCCGTTTGA

>15505_15505_3_CEACAM5-AP1G1_CEACAM5_chr19_42224127_ENST00000405816_AP1G1_chr16_71767062_ENST00000569748_length(amino acids)=623AA_BP=
MTKRSWNSSSSPQRRTEQTAETMESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWY
KGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVE
DKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTS
YRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDE
DAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYR
PGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CEACAM5-AP1G1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEACAM5-AP1G1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEACAM5-AP1G1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource