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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CELF2-GABRR1 (FusionGDB2 ID:15608)

Fusion Gene Summary for CELF2-GABRR1

check button Fusion gene summary
Fusion gene informationFusion gene name: CELF2-GABRR1
Fusion gene ID: 15608
HgeneTgene
Gene symbol

CELF2

GABRR1

Gene ID

10659

2569

Gene nameCUGBP Elav-like family member 2gamma-aminobutyric acid type A receptor subunit rho1
SynonymsBRUNOL3|CELF-2|CUG-BP2|CUGBP2|ETR-3|ETR3|NAPOR-
Cytomap

10p14

6q15

Type of geneprotein-codingprotein-coding
DescriptionCUGBP Elav-like family member 2CUG triplet repeat RNA-binding protein 2CUG-BP- and ETR-3-like factor 2ELAV-type RNA-binding protein 3KDM2B/CELF2 fusionRNA-binding protein BRUNOL-3bruno-like protein 3neuroblastoma apoptosis-related RNA-binding protegamma-aminobutyric acid receptor subunit rho-1GABA(A) receptor subunit rho-1GABA(A) receptor, rho 1GABA(C) receptorbA135P14.1 (gamma-aminobutyric acid (GABA) receptor, rho 1)gamma-aminobutyric acid (GABA) A receptor, rho-1gamma-aminobutyric acid (GA
Modification date2020031320200313
UniProtAcc

O95319

.
Ensembl transtripts involved in fusion geneENST00000450189, ENST00000542579, 
ENST00000399850, ENST00000417956, 
ENST00000315874, ENST00000354440, 
ENST00000354897, ENST00000379261, 
ENST00000416382, ENST00000427450, 
ENST00000537122, ENST00000608830, 
ENST00000609692, 		ENST00000369451, 
ENST00000435811, ENST00000481493, 
ENST00000454853, 
Fusion gene scores* DoF score18 X 17 X 4=12243 X 5 X 2=30
# samples 203
** MAII scorelog2(20/1224*10)=-2.61353165291793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/30*10)=0
Context

PubMed: CELF2 [Title/Abstract] AND GABRR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCELF2(11060126)-GABRR1(89913204), # samples:2
Anticipated loss of major functional domain due to fusion event.CELF2-GABRR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CELF2-GABRR1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCELF2

GO:0006376

mRNA splice site selection

11158314


check buttonFusion gene breakpoints across CELF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GABRR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1KZ-01ACELF2chr10

11060126

+GABRR1chr6

89913204

-
ChimerDB4SARCTCGA-RN-AAAQ-01ACELF2chr10

11060126

+GABRR1chr6

89895169

-
ChimerDB4SARCTCGA-RN-AAAQ-01ACELF2chr10

11060126

+GABRR1chr6

89913204

-


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Fusion Gene ORF analysis for CELF2-GABRR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000450189ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-5UTRENST00000542579ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-intronENST00000450189ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-intronENST00000450189ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-intronENST00000450189ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
5CDS-intronENST00000542579ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-intronENST00000542579ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-intronENST00000542579ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
5UTR-3CDSENST00000399850ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
5UTR-3CDSENST00000399850ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
5UTR-3CDSENST00000399850ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-3CDSENST00000399850ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
5UTR-3CDSENST00000417956ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
5UTR-3CDSENST00000417956ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
5UTR-3CDSENST00000417956ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-3CDSENST00000417956ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
5UTR-5UTRENST00000399850ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-5UTRENST00000417956ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-intronENST00000399850ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-intronENST00000399850ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-intronENST00000399850ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
5UTR-intronENST00000417956ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-intronENST00000417956ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-intronENST00000417956ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
Frame-shiftENST00000450189ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
Frame-shiftENST00000450189ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
Frame-shiftENST00000450189ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
Frame-shiftENST00000542579ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
Frame-shiftENST00000542579ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
Frame-shiftENST00000542579ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
In-frameENST00000450189ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
In-frameENST00000542579ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000315874ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000315874ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000315874ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000315874ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000354440ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000354440ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000354440ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000354440ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000354897ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000354897ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000354897ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000354897ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000379261ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000379261ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000379261ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000379261ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000416382ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000416382ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000416382ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000416382ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000427450ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000427450ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000427450ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000427450ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000537122ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000537122ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000537122ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000537122ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000608830ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000608830ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000608830ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000608830ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000609692ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000609692ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-3CDSENST00000609692ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000609692ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-5UTRENST00000315874ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000354440ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000354897ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000379261ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000416382ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000427450ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000537122ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000608830ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000609692ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000315874ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000315874ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000315874ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-intronENST00000354440ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000354440ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000354440ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-intronENST00000354897ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000354897ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000354897ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-intronENST00000379261ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000379261ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000379261ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-intronENST00000416382ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000416382ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000416382ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-intronENST00000427450ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000427450ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000427450ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-intronENST00000537122ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000537122ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000537122ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-intronENST00000608830ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000608830ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000608830ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-
intron-intronENST00000609692ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000609692ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000609692ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89895169

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000450189CELF2chr1011060126+ENST00000454853GABRR1chr689913204-2821234731551492
ENST00000542579CELF2chr1011060126+ENST00000454853GABRR1chr689913204-26617401391463

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000450189ENST00000454853CELF2chr1011060126+GABRR1chr689913204-0.0007031980.9992968
ENST00000542579ENST00000454853CELF2chr1011060126+GABRR1chr689913204-0.000522890.9994771

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Fusion Genomic Features for CELF2-GABRR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CELF2-GABRR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:11060126/chr6:89913204)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CELF2

O95319

.
FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250|UniProtKB:Q9Z0H4, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:11577082, ECO:0000269|PubMed:11931771, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:14973222, ECO:0000269|PubMed:15657417, ECO:0000269|PubMed:15894795, ECO:0000269|PubMed:28431233}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGABRR1chr10:11060126chr6:89913204ENST0000036945121222_2810393.0Topological domainExtracellular
TgeneGABRR1chr10:11060126chr6:89913204ENST00000369451212366_4570393.0Topological domainCytoplasmic
TgeneGABRR1chr10:11060126chr6:89913204ENST000004358110922_2810463.0Topological domainExtracellular
TgeneGABRR1chr10:11060126chr6:89913204ENST0000043581109366_4570463.0Topological domainCytoplasmic
TgeneGABRR1chr10:11060126chr6:89913204ENST00000454853010366_45740480.0Topological domainCytoplasmic
TgeneGABRR1chr10:11060126chr6:89913204ENST00000369451212282_3050393.0TransmembraneHelical
TgeneGABRR1chr10:11060126chr6:89913204ENST00000369451212309_3310393.0TransmembraneHelical
TgeneGABRR1chr10:11060126chr6:89913204ENST00000369451212343_3650393.0TransmembraneHelical
TgeneGABRR1chr10:11060126chr6:89913204ENST00000369451212458_4790393.0TransmembraneHelical
TgeneGABRR1chr10:11060126chr6:89913204ENST0000043581109282_3050463.0TransmembraneHelical
TgeneGABRR1chr10:11060126chr6:89913204ENST0000043581109309_3310463.0TransmembraneHelical
TgeneGABRR1chr10:11060126chr6:89913204ENST0000043581109343_3650463.0TransmembraneHelical
TgeneGABRR1chr10:11060126chr6:89913204ENST0000043581109458_4790463.0TransmembraneHelical
TgeneGABRR1chr10:11060126chr6:89913204ENST00000454853010282_30540480.0TransmembraneHelical
TgeneGABRR1chr10:11060126chr6:89913204ENST00000454853010309_33140480.0TransmembraneHelical
TgeneGABRR1chr10:11060126chr6:89913204ENST00000454853010343_36540480.0TransmembraneHelical
TgeneGABRR1chr10:11060126chr6:89913204ENST00000454853010458_47940480.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELF2chr10:11060126chr6:89913204ENST00000315874+114284_39702480.3333333333335Compositional biasNote=Ala-rich
HgeneCELF2chr10:11060126chr6:89913204ENST00000354440+113284_3970491.0Compositional biasNote=Ala-rich
HgeneCELF2chr10:11060126chr6:89913204ENST00000379261+114284_39701807.0Compositional biasNote=Ala-rich
HgeneCELF2chr10:11060126chr6:89913204ENST00000399850+114284_3970759.6666666666666Compositional biasNote=Ala-rich
HgeneCELF2chr10:11060126chr6:89913204ENST00000416382+114284_3970767.0Compositional biasNote=Ala-rich
HgeneCELF2chr10:11060126chr6:89913204ENST00000417956+114284_3970757.6666666666666Compositional biasNote=Ala-rich
HgeneCELF2chr10:11060126chr6:89913204ENST00000427450+115284_39702400.0Compositional biasNote=Ala-rich
HgeneCELF2chr10:11060126chr6:89913204ENST00000315874+114132_21202480.3333333333335DomainRRM 2
HgeneCELF2chr10:11060126chr6:89913204ENST00000315874+11440_12302480.3333333333335DomainRRM 1
HgeneCELF2chr10:11060126chr6:89913204ENST00000315874+114423_50102480.3333333333335DomainRRM 3
HgeneCELF2chr10:11060126chr6:89913204ENST00000354440+113132_2120491.0DomainRRM 2
HgeneCELF2chr10:11060126chr6:89913204ENST00000354440+11340_1230491.0DomainRRM 1
HgeneCELF2chr10:11060126chr6:89913204ENST00000354440+113423_5010491.0DomainRRM 3
HgeneCELF2chr10:11060126chr6:89913204ENST00000379261+114132_21201807.0DomainRRM 2
HgeneCELF2chr10:11060126chr6:89913204ENST00000379261+11440_12301807.0DomainRRM 1
HgeneCELF2chr10:11060126chr6:89913204ENST00000379261+114423_50101807.0DomainRRM 3
HgeneCELF2chr10:11060126chr6:89913204ENST00000399850+114132_2120759.6666666666666DomainRRM 2
HgeneCELF2chr10:11060126chr6:89913204ENST00000399850+11440_1230759.6666666666666DomainRRM 1
HgeneCELF2chr10:11060126chr6:89913204ENST00000399850+114423_5010759.6666666666666DomainRRM 3
HgeneCELF2chr10:11060126chr6:89913204ENST00000416382+114132_2120767.0DomainRRM 2
HgeneCELF2chr10:11060126chr6:89913204ENST00000416382+11440_1230767.0DomainRRM 1
HgeneCELF2chr10:11060126chr6:89913204ENST00000416382+114423_5010767.0DomainRRM 3
HgeneCELF2chr10:11060126chr6:89913204ENST00000417956+114132_2120757.6666666666666DomainRRM 2
HgeneCELF2chr10:11060126chr6:89913204ENST00000417956+11440_1230757.6666666666666DomainRRM 1
HgeneCELF2chr10:11060126chr6:89913204ENST00000417956+114423_5010757.6666666666666DomainRRM 3
HgeneCELF2chr10:11060126chr6:89913204ENST00000427450+115132_21202400.0DomainRRM 2
HgeneCELF2chr10:11060126chr6:89913204ENST00000427450+11540_12302400.0DomainRRM 1
HgeneCELF2chr10:11060126chr6:89913204ENST00000427450+115423_50102400.0DomainRRM 3
HgeneCELF2chr10:11060126chr6:89913204ENST00000315874+1141_28302480.3333333333335RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000315874+114357_50802480.3333333333335RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000354440+1131_2830491.0RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000354440+113357_5080491.0RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000379261+1141_28301807.0RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000379261+114357_50801807.0RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000399850+1141_2830759.6666666666666RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000399850+114357_5080759.6666666666666RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000416382+1141_2830767.0RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000416382+114357_5080767.0RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000417956+1141_2830757.6666666666666RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000417956+114357_5080757.6666666666666RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000427450+1151_28302400.0RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
HgeneCELF2chr10:11060126chr6:89913204ENST00000427450+115357_50802400.0RegionNote=Necessary for RNA-binding%2C TNNT2 exon 5 and NMDA R1 exon 21 inclusion
TgeneGABRR1chr10:11060126chr6:89913204ENST0000045485301022_28140480.0Topological domainExtracellular


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Fusion Gene Sequence for CELF2-GABRR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15608_15608_1_CELF2-GABRR1_CELF2_chr10_11060126_ENST00000450189_GABRR1_chr6_89913204_ENST00000454853_length(transcript)=2821nt_BP=234nt
GGGGATTGGCGGAGCGCGAGGAGAGAATGTGACAAGTGCCGGCTCGGCGGCCGCCGGGGGAGGCCGCGCGCACCTGTCCCTGCCCGTCTC
GCGCCGCCCGCGGCCGCTCGGACGCGCGCAGAGCCGCCCCCCGCCGCTGCCGCCGCGTGCGCCCGCGAACATGACTTCTGCCTTCAAGCT
GGATTTCCTCCCGGACATGATGGTCGAGGGCCGCCTGCTCGTTCCTGACAGAATGCCCCAAAGACAAAGACGAGAAGTACATGAAGATGC
CCACAAGCAAGTCAGCCCAATTCTGAGACGAAGTCCTGACATCACCAAATCGCCTCTGACAAAGTCAGAACAGCTTCTGAGGATAGATGA
CCATGATTTCAGCATGAGGCCTGGCTTTGGAGGCCCTGCCATTCCTGTTGGTGTGGATGTGCAGGTGGAGAGTTTGGATAGCATCTCAGA
GGTTGACATGGACTTTACGATGACCCTCTACCTGAGGCACTACTGGAAGGACGAGAGGCTGTCTTTTCCAAGCACCAACAACCTCAGCAT
GACGTTTGACGGCCGGCTGGTCAAGAAGATCTGGGTCCCTGACATGTTTTTCGTGCACTCCAAACGCTCCTTCATCCACGACACCACCAC
AGACAACGTCATGTTGCGGGTCCAGCCTGATGGGAAAGTGCTCTATAGTCTCAGGGTTACAGTAACTGCAATGTGCAACATGGACTTCAG
CCGATTTCCCTTGGACACACAAACGTGCTCTCTTGAAATTGAAAGCTATGCCTATACAGAAGATGACCTCATGCTGTACTGGAAAAAGGG
CAATGACTCCTTAAAGACAGATGAACGGATCTCACTCTCCCAGTTCCTCATTCAGGAATTCCACACCACCACCAAACTGGCTTTCTACAG
CAGCACAGGCTGGTACAACCGTCTCTACATTAATTTCACGTTGCGTCGCCACATCTTCTTCTTCTTGCTCCAAACTTATTTCCCCGCTAC
CCTGATGGTCATGCTGTCCTGGGTGTCCTTCTGGATCGACCGCAGAGCCGTGCCTGCCAGAGTCCCCTTAGGTATCACAACGGTGCTGAC
CATGTCCACCATCATCACGGGCGTGAATGCCTCCATGCCGCGCGTCTCCTACATCAAGGCCGTGGACATCTACCTCTGGGTCAGCTTTGT
GTTCGTGTTCCTCTCGGTGCTGGAGTATGCGGCCGTCAACTACCTGACCACTGTGCAGGAGAGGAAGGAACAGAAGCTGCGGGAGAAGCT
TCCCTGCACCAGCGGATTACCTCCGCCCCGCACTGCGATGCTGGACGGCAACTACAGTGATGGGGAGGTGAATGACCTGGACAACTACAT
GCCAGAGAATGGAGAGAAGCCCGACAGGATGATGGTGCAGCTGACCCTGGCCTCAGAGAGGAGCTCCCCACAGAGGAAAAGTCAGAGAAG
CAGCTATGTGAGCATGAGAATCGACACCCACGCCATTGATAAATACTCCAGGATCATCTTTCCAGCAGCATACATTTTATTCAATTTAAT
ATACTGGTCTATTTTCTCCTAGATGCTTGTAATTCTACAAATTTCACATTTCCATGGCATGCACTACAGAAATAACTGTATAATGAAAAA
GTATTTAAGGATATGGTTAAAAAAAAATCCCAGGACCCACCCATGTTTTCACTATCCCTTCTGCAGCTTTCCAAAGCTACATTGACGAGA
CACTTACTGGTTTAATTTGCACTTATTAACCATCTATTGAATACACAGCATTATATTAGGTGCTGCAGGAAATACGACACTGTAGCGACT
GATGTTAGTTGTTACCCAGATCCCCTGGAAAAGCACACTACCAGTGTTGTGGGCACATTTAGTTCCACCCGTTAGACCCTTGATGCTATT
CACATGAATAATTTATTTTCCTCAAGTGTCATTACATTGTTCAGGCTACGTGAACTTGGAAGCACCTACAGGCCATTTGCATGAAATTCA
CATGCACCTAAATCCTCACTTTGACAGAAACTCATGCTTCAGTTTATAACCTATTACCTATTTTGTATGCGACTCCACCTCCGCATGTTT
ATTTTAATAAAAGGCAATGATAACATTCACATTATTTTTCTTTATATGCTGTGGTTCACAGGCTTTACCCCTTCACAAGAAAAGCTCTTT
AGATTGGCGCAATTGCTTCTGATTTTGGTGAAATTTTCCCTGGTAGGGAAACTTTGAAGATAAGAGTACACACATGCATTTTGTCTGTTG
TGTCATAGAGGTAACTAGGCTAGAAAATTTGTGTTTAAATGTTCCCTATTTTATATAATCACCACTTCATGTTTCTTCTTCTTGGAGCAT
GTCCTTGTTCAAAGAGAAGTGCTTTCTCAGTGATGTGATATCTTCACTGAGGAACTTGGGTAGAGAATGATTTCTTCTGCATAAACACTT
CAAGGAAATACATAATTTGGGACTACTTGTAACTCATTAGAATGAGAAATACTCACATGGTTTCTTAAGAGAAAAAGAACATCGGAAAGC
AAAATAAATGGGAAGATATCACTGGACATCTGCATTTATACTCGAAATACCAGCATTTTCTATGGACCAGAAAACTGCCATCACCTAGAC
CACACAGCCCAGATACCAGGCAGACGGATGGCCCAATGGCAACTGATGTCAGGGCATGGGGTAAAGGAGAGGGTTCTAATCTGGTGTATC
ACTTAAAAACAGTTATTTATATTATATATCTGCTATATAGATCAACCTCCACCAAACTTACCCAAACAGCATTTGTTTTATTTGAAACTC

>15608_15608_1_CELF2-GABRR1_CELF2_chr10_11060126_ENST00000450189_GABRR1_chr6_89913204_ENST00000454853_length(amino acids)=492AA_BP=54
MSLPVSRRPRPLGRAQSRPPPLPPRAPANMTSAFKLDFLPDMMVEGRLLVPDRMPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQ
LLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSF
IHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTT
KLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIY
LWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQ

--------------------------------------------------------------
>15608_15608_2_CELF2-GABRR1_CELF2_chr10_11060126_ENST00000542579_GABRR1_chr6_89913204_ENST00000454853_length(transcript)=2661nt_BP=74nt
ATGACTTCTGCCTTCAAGCTGGATTTCCTCCCGGACATGATGGTCGAGGGCCGCCTGCTCGTTCCTGACAGAATGCCCCAAAGACAAAGA
CGAGAAGTACATGAAGATGCCCACAAGCAAGTCAGCCCAATTCTGAGACGAAGTCCTGACATCACCAAATCGCCTCTGACAAAGTCAGAA
CAGCTTCTGAGGATAGATGACCATGATTTCAGCATGAGGCCTGGCTTTGGAGGCCCTGCCATTCCTGTTGGTGTGGATGTGCAGGTGGAG
AGTTTGGATAGCATCTCAGAGGTTGACATGGACTTTACGATGACCCTCTACCTGAGGCACTACTGGAAGGACGAGAGGCTGTCTTTTCCA
AGCACCAACAACCTCAGCATGACGTTTGACGGCCGGCTGGTCAAGAAGATCTGGGTCCCTGACATGTTTTTCGTGCACTCCAAACGCTCC
TTCATCCACGACACCACCACAGACAACGTCATGTTGCGGGTCCAGCCTGATGGGAAAGTGCTCTATAGTCTCAGGGTTACAGTAACTGCA
ATGTGCAACATGGACTTCAGCCGATTTCCCTTGGACACACAAACGTGCTCTCTTGAAATTGAAAGCTATGCCTATACAGAAGATGACCTC
ATGCTGTACTGGAAAAAGGGCAATGACTCCTTAAAGACAGATGAACGGATCTCACTCTCCCAGTTCCTCATTCAGGAATTCCACACCACC
ACCAAACTGGCTTTCTACAGCAGCACAGGCTGGTACAACCGTCTCTACATTAATTTCACGTTGCGTCGCCACATCTTCTTCTTCTTGCTC
CAAACTTATTTCCCCGCTACCCTGATGGTCATGCTGTCCTGGGTGTCCTTCTGGATCGACCGCAGAGCCGTGCCTGCCAGAGTCCCCTTA
GGTATCACAACGGTGCTGACCATGTCCACCATCATCACGGGCGTGAATGCCTCCATGCCGCGCGTCTCCTACATCAAGGCCGTGGACATC
TACCTCTGGGTCAGCTTTGTGTTCGTGTTCCTCTCGGTGCTGGAGTATGCGGCCGTCAACTACCTGACCACTGTGCAGGAGAGGAAGGAA
CAGAAGCTGCGGGAGAAGCTTCCCTGCACCAGCGGATTACCTCCGCCCCGCACTGCGATGCTGGACGGCAACTACAGTGATGGGGAGGTG
AATGACCTGGACAACTACATGCCAGAGAATGGAGAGAAGCCCGACAGGATGATGGTGCAGCTGACCCTGGCCTCAGAGAGGAGCTCCCCA
CAGAGGAAAAGTCAGAGAAGCAGCTATGTGAGCATGAGAATCGACACCCACGCCATTGATAAATACTCCAGGATCATCTTTCCAGCAGCA
TACATTTTATTCAATTTAATATACTGGTCTATTTTCTCCTAGATGCTTGTAATTCTACAAATTTCACATTTCCATGGCATGCACTACAGA
AATAACTGTATAATGAAAAAGTATTTAAGGATATGGTTAAAAAAAAATCCCAGGACCCACCCATGTTTTCACTATCCCTTCTGCAGCTTT
CCAAAGCTACATTGACGAGACACTTACTGGTTTAATTTGCACTTATTAACCATCTATTGAATACACAGCATTATATTAGGTGCTGCAGGA
AATACGACACTGTAGCGACTGATGTTAGTTGTTACCCAGATCCCCTGGAAAAGCACACTACCAGTGTTGTGGGCACATTTAGTTCCACCC
GTTAGACCCTTGATGCTATTCACATGAATAATTTATTTTCCTCAAGTGTCATTACATTGTTCAGGCTACGTGAACTTGGAAGCACCTACA
GGCCATTTGCATGAAATTCACATGCACCTAAATCCTCACTTTGACAGAAACTCATGCTTCAGTTTATAACCTATTACCTATTTTGTATGC
GACTCCACCTCCGCATGTTTATTTTAATAAAAGGCAATGATAACATTCACATTATTTTTCTTTATATGCTGTGGTTCACAGGCTTTACCC
CTTCACAAGAAAAGCTCTTTAGATTGGCGCAATTGCTTCTGATTTTGGTGAAATTTTCCCTGGTAGGGAAACTTTGAAGATAAGAGTACA
CACATGCATTTTGTCTGTTGTGTCATAGAGGTAACTAGGCTAGAAAATTTGTGTTTAAATGTTCCCTATTTTATATAATCACCACTTCAT
GTTTCTTCTTCTTGGAGCATGTCCTTGTTCAAAGAGAAGTGCTTTCTCAGTGATGTGATATCTTCACTGAGGAACTTGGGTAGAGAATGA
TTTCTTCTGCATAAACACTTCAAGGAAATACATAATTTGGGACTACTTGTAACTCATTAGAATGAGAAATACTCACATGGTTTCTTAAGA
GAAAAAGAACATCGGAAAGCAAAATAAATGGGAAGATATCACTGGACATCTGCATTTATACTCGAAATACCAGCATTTTCTATGGACCAG
AAAACTGCCATCACCTAGACCACACAGCCCAGATACCAGGCAGACGGATGGCCCAATGGCAACTGATGTCAGGGCATGGGGTAAAGGAGA
GGGTTCTAATCTGGTGTATCACTTAAAAACAGTTATTTATATTATATATCTGCTATATAGATCAACCTCCACCAAACTTACCCAAACAGC

>15608_15608_2_CELF2-GABRR1_CELF2_chr10_11060126_ENST00000542579_GABRR1_chr6_89913204_ENST00000454853_length(amino acids)=463AA_BP=25
MTSAFKLDFLPDMMVEGRLLVPDRMPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVE
SLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTA
MCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLL
QTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKE
QKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAA

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Fusion Gene PPI Analysis for CELF2-GABRR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CELF2-GABRR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CELF2-GABRR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource