Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CELF2-IDS (FusionGDB2 ID:15609)

Fusion Gene Summary for CELF2-IDS

Fusion gene summary

Fusion gene information	Fusion gene name: CELF2-IDS
	Fusion gene ID: 15609
		Hgene	Tgene
	Gene symbol	CELF2	IDS
	Gene ID	10659	3423
	Gene name	CUGBP Elav-like family member 2	iduronate 2-sulfatase
	Synonyms	BRUNOL3\|CELF-2\|CUG-BP2\|CUGBP2\|ETR-3\|ETR3\|NAPOR	ID2S\|MPS2\|SIDS
	Cytomap	10p14	Xq28
	Type of gene	protein-coding	protein-coding
	Description	CUGBP Elav-like family member 2CUG triplet repeat RNA-binding protein 2CUG-BP- and ETR-3-like factor 2ELAV-type RNA-binding protein 3KDM2B/CELF2 fusionRNA-binding protein BRUNOL-3bruno-like protein 3neuroblastoma apoptosis-related RNA-binding prote	iduronate 2-sulfatasealpha-L-iduronate sulfate sulfataseiduronate 2-sulfatase 14 kDa chainiduronate 2-sulfatase 42 kDa chainidursulfase
	Modification date	20200313	20200313
	UniProtAcc	O95319	P22304
	Ensembl transtripts involved in fusion gene	ENST00000315874, ENST00000354440, ENST00000354897, ENST00000379261, ENST00000399850, ENST00000416382, ENST00000417956, ENST00000427450, ENST00000450189, ENST00000537122, ENST00000542579, ENST00000608830, ENST00000609692,	ENST00000340855, ENST00000370441, ENST00000370443, ENST00000422081, ENST00000427113, ENST00000428056, ENST00000490775, ENST00000537071, ENST00000541269,
Fusion gene scores	* DoF score	18 X 17 X 4=1224	9 X 9 X 4=324
	# samples	20	9
	** MAII score	log2(20/1224*10)=-2.61353165291793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/324*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CELF2 [Title/Abstract] AND IDS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CELF2(10605516)-IDS(148562123), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CELF2	GO:0006376	mRNA splice site selection	11158314
Tgene	IDS	GO:0006027	glycosaminoglycan catabolic process	28593992

Fusion gene breakpoints across CELF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IDS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CD643231	CELF2	chr10	10605516	+	IDS	chrX	148562123	-

Top

Fusion Gene ORF analysis for CELF2-IDS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000315874	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000354440	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000354897	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000379261	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000399850	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000416382	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000417956	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000427450	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000450189	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000537122	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000542579	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000608830	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-3UTR	ENST00000609692	ENST00000340855	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000315874	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000315874	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000315874	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000315874	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000315874	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000315874	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000315874	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000315874	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354440	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354440	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354440	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354440	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354440	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354440	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354440	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354440	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354897	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354897	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354897	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354897	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354897	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354897	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354897	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000354897	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000379261	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000379261	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000379261	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000379261	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000379261	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000379261	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000379261	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000379261	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000399850	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000399850	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000399850	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000399850	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000399850	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000399850	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000399850	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000399850	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000416382	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000416382	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000416382	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000416382	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000416382	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000416382	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000416382	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000416382	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000417956	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000417956	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000417956	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000417956	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000417956	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000417956	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000417956	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000417956	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000427450	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000427450	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000427450	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000427450	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000427450	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000427450	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000427450	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000427450	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000450189	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000450189	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000450189	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000450189	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000450189	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000450189	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000450189	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000450189	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000537122	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000537122	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000537122	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000537122	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000537122	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000537122	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000537122	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000537122	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000542579	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000542579	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000542579	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000542579	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000542579	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000542579	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000542579	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000542579	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000608830	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000608830	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000608830	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000608830	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000608830	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000608830	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000608830	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000608830	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000609692	ENST00000370441	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000609692	ENST00000370443	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000609692	ENST00000422081	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000609692	ENST00000427113	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000609692	ENST00000428056	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000609692	ENST00000490775	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000609692	ENST00000537071	CELF2	chr10	10605516	+	IDS	chrX	148562123	-
intron-intron	ENST00000609692	ENST00000541269	CELF2	chr10	10605516	+	IDS	chrX	148562123	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for CELF2-IDS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CELF2-IDS

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:10605516/:148562123)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CELF2 O95319	IDS P22304
FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250\|UniProtKB:Q9Z0H4, ECO:0000269\|PubMed:11158314, ECO:0000269\|PubMed:11577082, ECO:0000269\|PubMed:11931771, ECO:0000269\|PubMed:12649496, ECO:0000269\|PubMed:14973222, ECO:0000269\|PubMed:15657417, ECO:0000269\|PubMed:15894795, ECO:0000269\|PubMed:28431233}.	FUNCTION: Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. {ECO:0000269\|PubMed:10838181, ECO:0000269\|PubMed:11731225, ECO:0000269\|PubMed:28593992}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for CELF2-IDS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CELF2-IDS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CELF2-IDS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CELF2-IDS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source